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IRF4 Gene

protein-coding GIFtS: 63

GC06P000336

interferon regulatory factor 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MUM1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
IRF-4 ^³
LSIRF ^¹, ², ³, ⁵
MUM1 ^², ³
NF-EM5 ^³
OTTHUMP00000017905 ^²

Descriptions
Lymphocyte-specific interferon regulatory factor ^³
Multiple myeloma oncogene 1 ^², ³
interferon regulatory factor 4 ^²

External Ids
HGNC: 6119¹
Entrez Gene: 3662²
UniProtKB: Q15306³
Ensembl: ENSG00000137265⁷

Search outside databases for aliases for IRF4 gene

Previous GC identifers: GC06U990070 GC06P000377

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IRF4_HUMAN, Q15306

Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of

the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with

PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid

cells

Gene Wiki entry for IRF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IRF4 gene

Entrez Gene cytogenetic band: 6p25-p23 Ensembl cytogenetic band: 6p25.3 HGNC cytogenetic band: 6p25-p23

IRF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P000336: (about GC identifiers)

Start:	336,760 bp from pter
End:	356,193 bp from pter
Size:	19,434 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_034880.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IRF4_HUMAN, Q15306 (See protein sequence)

Recommended Name: Interferon regulatory factor 4

Size: 451 amino acids; 51772 Da

Subunit: Interacts with SPIB and DEF6

Subcellular location: Nucleus

PDB structures from and Proteopedia :

2DLL (3D)

Secondary accessions: Q5VUI7 Q99660

Alternative splicing: 2 isoforms: Q15306-1 Q15306-2

REFSEQ proteins: NP_002451.2

ENSEMBL proteins:

ENSP00000370343

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MUM1)
	Human Recombinant Proteins from Abnova (IRF4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	12374808
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for IRF4:

	Invitrogen Antibodies for IRF4
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IRF4
	R&D Systems Antibodies for IRF4
	Cell Signaling Technology (CST) Antibodies for IRF4 (IRF)
	Antibodies from Abcam (MUM1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IRF4)
	Novus Biologicals Antibodies for IRF4

Assays for IRF4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15306

ProtoNet protein and cluster: Q15306

1 Blocks protein family: IPB001346 Interferon regulatory factor

UniProtKB/Swiss-Prot: IRF4_HUMAN, Q15306

Similarity: Belongs to the IRF family

Similarity: Contains 1 tryptophan pentad repeat DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IRF4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IRF4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC015752

Applied Biosystems Silencer® siRNAs for IRF4

Sigma-Aldrich siRNA for IRF4

Sigma-Aldrich shRNA Panels and shRNA for IRF4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IRF4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002460
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002460
untagged cDNA clones in CMV expression vector (see all 2): BC015752

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC015752

UniProtKB/Swiss-Prot: IRF4_HUMAN, Q15306

Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of

the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with

PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid

cells

Induction: Not induced by interferons

Genatlas biochemistry entry for IRF4:

interferon regulatory factor 4,lymphocyte-specific, controlling the B-cell proliferation and

differentiation,protooncogene deregulated in multiple myeloma with translocation t(6;14)(p25;q32)

(see MUM1)

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Irf4):

hematopoietic system

immune system

tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	12374808
GO:0003702	RNA polymerase II transcription factor activity	TAS	8921401
GO:0008134	transcription factor binding	NAS	12374808
GO:0016563	transcription activator activity	IDA	12374808

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for IRF4 (Your Favorite Gene powered by Ingenuity)

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
IL-4 Signaling

GeneDecks IRF4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IRF4

5/60 Interacting proteins for IRF4 (ENSP00000370343³) via UniProtKB, MINT, and/or STRING (see all 60 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL6	ENSP00000232014³	STRING (score=.999)
NFATC2	ENSP00000360622³	STRING (score=.997)
PRDM1	ENSP00000071246³	STRING (score=.979)
SPI1	ENSP00000367799³	STRING (score=.978)
MAF	ENSP00000327048³	STRING (score=.964)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0042110	T cell activation	NAS	12374808
GO:0043011	myeloid dendritic cell differentiation	IEA	--
GO:0045082	positive regulation of interleukin-10 biosynthetic process	IDA	12374808
GO:0045086	positive regulation of interleukin-2 biosynthetic process	IDA	12374808

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IRF4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IRF4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IRF4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC015752

Sigma-Aldrich siRNA for IRF4

Sigma-Aldrich shRNA Panels and shRNA for IRF4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002460

REFSEQ mRNAs for IRF4 gene:

NM_002460.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002460

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002460
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002460
                                 untagged cDNA clones in CMV expression vector (see all 2): BC015752

Additional cDNA sequence:

AK130762.1 AK310149.1 BC015752.1 D78261.1 U52682.1 U63738.1

7 DOTS entries:

DT.95373806 DT.415498 DT.101954966 DT.101967303 DT.100027176 DT.121369596 DT.121369597

24/202 AceView cDNA sequences (see all 202 ):

BG230623 AI125911 BM466161 AI224170 BM472499 BP338226 AA377285 BQ213771

BX112230 BX646222 AW204321 BG762018 CD520520 AW407522 BQ221956 BU838100

AW452687 BQ683656 AW448970 AA227826 BG390289 BU147350 AI824002 CD521701

highest scoring ESTs for IRF4:

D78261 U52682 AA255768 BC015752 BE151052 BF128693 BM551611 BQ425272 CF137158 CF137957

Unigene Cluster for IRF4:

Interferon regulatory factor 4

Hs.401013 [show with all ESTs]

Unigene Representative Sequence: U52682

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IRF4 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11
SP1:													-		-				-		-						-								-				-
SP2:													-		-				-		-						-								-				-
SP3:													-		-				-		-						-								-
SP4:									-				-		-				-		-						-
SP5:																			-		-

About this scheme

ECgene alternative splicing isoforms for IRF4

1 Ensembl transcript including schematic representation:

ENST00000380956

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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IRF4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IRF4

¹ / ² / ³

10 probe-sets matching IRF4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59130_at²^{, 3}	U95-C	1	1.00	1.00	0.89	1.19	AA866137	0.60	1.00	0.82	1
37627_g_at²^{, 3}	U95-A	1	1.00	1.00	0.72	0.25	D78261	1.00	1.00	1.00	1
37626_at²^{, 3}	U95-A	1	1.00	1.00	0.49	0.20	D78261	1.00	1.00	1.00	1
37625_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.85	U52682	1.00	1.00	1.00	1
204562_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002460	0.60	1.00	0.82	1
216986_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D78261	1.00	1.00	1.00	1
216987_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D78261	1.00	1.00	1.00	1
204562_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216986_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216987_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IRF4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.401013
Expression variation in blood from EXPOLDB for IRF4
UniProtKB/Swiss-Prot: IRF4_HUMAN, Q15306
Tissue specificity: Lymphoid cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IRF4 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	IRF4¹	--	interferon regulatory factor 4	99.48(n) 99.11(a)	462386 XM_518201.2 XP_518201.2
cow (Bos taurus)	IRF4¹	--	similar to interferon regulatory factor 4	89.14(n) 93.13(a)	506141 XM_865312.2 XP_870405.2
rat (Rattus norvegicus)	Irf4¹	--	interferon regulatory factor 4	88.44(n) 91.78(a)	291100 XM_225283.4 XP_225283.4
mouse (Mus musculus)	Irf4^{1, 5}	13⁵	interferon regulatory factor 4^{1, 5}	87.93(n)¹ 91.78(a)¹	16364¹ NM_013674.1¹ NP_038702.1¹ AI385587⁵ AK089319⁵ (see all 16)
chicken (Gallus gallus)	IRF4¹	--	interferon regulatory factor 4	80.41(n) 85.14(a)	374179 NM_204299.1 NP_989630.1

About this table Species with no ortholog for IRF4

ENSEMBL Gene Tree for IRF4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for IRF4 gene

IRF8² IRF9² IRF5² IRF6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/193 NCBI SNPs in IRF4 are shown (see all 193 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 97)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1050975^1,2	A,C,F,H,O	353012(+)	`GTTCTA/GTAGAC`	1	--	ut3¹ ese³		12	MN NA EU EA WA	1140
	rs4959248^1,2	A,C,F,H	352882(+)	`AGGAAC/TTCAGA`	1	--	ut3¹ ese³		6	NA EU EA	410
	rs872071^1,2	A,C,F,H	356064(+)	`AGGGGA/GCGTGA`	1	--	ut3¹ ese³		14	MN EA EU WA NA	2862
	rs1877175^1,2	A,C,F,H	355493(+)	`CAGTGG/AAATGA`	1	--	ut3¹		13	MN EA NA EU WA	1150
--	rs9391997^1,2	A,C,F,H	354119(+)	`TTTCTA/GATGGA`	1	--	ut3¹ ese³		8	EA NA EU WA	604
	rs9392502^1,2	A,C,F,H	355608(+)	`CAACTC/GTGGGA`	1	--	ut3¹ ese³		5	MN EU EA WA	594
	rs7768807^1,2	A,C,F,H	353246(+)	`ATTAAT/CGTATG`	1	--	ut3¹		8	EA NA EU WA	604
	rs6906608^1,2	A,C,F,H	356554(+)	`CAGATC/ATCCAA`	1	--	ng3¹		16	EU EA WA	1678
	rs6899334^1,2	C,F,H	335105(+)	`AAATCT/CGTGAA`	1	--	ng5¹		4	EU EA WA	420
	rs1877176^1,2	A,C,F	355513(+)	`ACAGTG/ATTGTT`	1	--	ut3¹		5	MN EA NA	380

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HapMap Linkage Disequilibrium images for IRF4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601900

UniProtKB/Swiss-Prot: IRF4_HUMAN, Q15306

A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500].

Translocation t(6;14)(p25;q32) with the IgH locus

10/18 Novoseek disease relationships for IRF4 gene (see all 18 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma b-cell	74.75	10	15710572 (2), 15959530 (2), 17149956 (1), 18987657 (1) (see all 7)
leukemia t-cell	58.04	6	11749693 (1), 12218129 (1), 15684621 (1), 10714679 (1)
lymphoma	57.20	10	18417578 (2), 17138822 (1), 19103865 (1), 17517757 (1) (see all 9)
plasmacytoma	49.39	3	15507667 (1), 18089822 (1)
myeloma	48.59	8	18568025 (4), 18987657 (1), 18761464 (1)
hodgkin disease	41.69	6	18410414 (3), 10706878 (1)
lymphoma follicular	41.55	3	17296585 (2)
malt lymphoma	41.29	1	15710572 (1)
lymphoma non-hodgkins	37.45	1	12594241 (1)
paraparesis tropical spastic	35.44	1	11846984 (1)

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1 PharmGKB disease relationship for IRF4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

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Human Genome Epidemiology Navigator: IRF4 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/150 PubMed articles for IRF4 gene (see all 150 ):

Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25. (PubMed id 8921401)^{1, 2, 3, 4} Grossman A.... Mak T.W. (1996)
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes. (PubMed id 18417578)^{1, 2, 3} Xu D....Zhang L. (2008)
Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. (PubMed id 9326949)^{1, 3, 4} Iida S.... Dalla-Favera R. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (PubMed id 10196196)^{3, 4} Rao S.... Simon M.C. (1999)
Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia. (PubMed id 11749693)^{1, 3} Imaizumi Y....Matsuyama T. (2001)
Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4). (PubMed id 12566414)^{1, 3} Fanzo J.C....Pernis A.B. (2003)
Modulation of T cell cytokine production by interferon regulatory factor-4. (PubMed id 12374808)^{1, 3} Hu C.M....Pernis A.B. (2002)
Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells. (PubMed id 12218129)^{1, 3} Sharma S....Hiscott J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3662	HGNC: 6119	AceView: IRF4	Ensembl:ENSG00000137265	euGenes: HUgn3662
ECgene: IRF4	H-InvDB: IRF4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for IRF4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for IRF4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IRF4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IRF4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IRF4		Antibodies for IRF4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IRF4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IRF4)
	Antibodies (IRF4)
	Chimera RNAi (IRF4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for IRF4 (IRF)

	Recombinant Proteins (MUM1)
	Antibodies (MUM1)

Search OriGene for IRF4

Search Tocris compounds for IRF4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IRF4

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IRF4 Gene at Home site.
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IRF4 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for IRF4

Summaries
for IRF4

Genomic Location
for IRF4

Proteins
for IRF4

Protein Domains/
Families
for IRF4

Gene Function
for IRF4

Pathways & Interactions
for IRF4

Drugs & Compounds
for IRF4

Transcripts
for IRF4

Expression
for IRF4

Orthologs
for IRF4

Paralogs
for IRF4

SNPs/Variants
for IRF4

Disorders & Mutations
for IRF4

Medical News
for IRF4

Publications
for IRF4

Search for IRF4

Genome Databases showing IRF4

Other Databases showing IRF4

Specialized Databases showing IRF4

Licensable Technologies
for IRF4

Services
for IRF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IRF4 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor IRF4

Summariesfor IRF4

Genomic Locationfor IRF4

Proteinsfor IRF4

Protein Domains/Familiesfor IRF4

Gene Functionfor IRF4

Pathways & Interactionsfor IRF4

Drugs & Compoundsfor IRF4

Transcriptsfor IRF4

Expression for IRF4

Orthologsfor IRF4

Paralogsfor IRF4

SNPs/Variantsfor IRF4

Disorders & Mutationsfor IRF4

Medical Newsfor IRF4

Publicationsfor IRF4

Search for IRF4

Genome Databases showing IRF4

Other Databases showing IRF4

Specialized Databases showing IRF4

Licensable Technologiesfor IRF4

Servicesfor IRF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IRF4

Summaries
for IRF4

Genomic Location
for IRF4

Proteins
for IRF4

Protein Domains/
Families
for IRF4

Gene Function
for IRF4

Pathways & Interactions
for IRF4

Drugs & Compounds
for IRF4

Transcripts
for IRF4

Expression
for IRF4

Orthologs
for IRF4

Paralogs
for IRF4

SNPs/Variants
for IRF4

Disorders & Mutations
for IRF4

Medical News
for IRF4

Publications
for IRF4

Licensable Technologies
for IRF4

Services
for IRF4