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IRF3 Gene

protein-coding   GIFtS: 68
GCID: GC19M050162

Interferon Regulatory Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Regulatory Factor 31 2
IRF-33

External Ids:    HGNC: 61181   Entrez Gene: 36612   Ensembl: ENSG000001264567   OMIM: 6037345   UniProtKB: Q146533   

Export aliases for IRF3 gene to outside databases

Previous GC identifers: GC19M050821 GC19M050530 GC19M054838 GC19M054854 GC19M046539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRF3 Gene:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is
found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.
This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well
as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for IRF3 Gene:
IRF3 (interferon regulatory factor 3) is a protein-coding gene. Diseases associated with IRF3 include hantavirus pulmonary syndrome, and newcastle disease. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRF8.

UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653
Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a
critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I
IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response
element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha
(IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an
inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or
toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational
change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP)
to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG
genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in
primary macrophages

Gene Wiki entry for IRF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRF3 gene promoter:
         STAT1   AP-1   p53   ATF-2   p300   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IRF3 promoter sequence
   Search Chromatin IP Primers for IRF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3-q13.4

IRF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050162:  view genomic region     (about GC identifiers)

Start:
50,162,826 bp from pter      End:
50,169,132 bp from pter
Size:
6,307 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653 (See protein sequence)
Recommended Name: Interferon regulatory factor 3  
Size: 427 amino acids; 47219 Da
Subunit: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact
with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with RBCK1. Interacts with
TRIM21. Interacts with HERC5. InteractS with DDX3X (phosphorylated at 'Ser-102'); the interaction allows the
phosphorylation and activation of IRF3 by IKBKE. Interacts with rotavirus A NSP1 (via C-terminus); this
interaction leads to the proteasome-dependent degradation of IRF3. Interacts with herpes virus 8/HHV-8 protein
vIRF-1
Selected PDB 3D structures from and Proteopedia for IRF3 (see all 9):
1J2F (3D)        1QWT (3D)        1T2K (3D)        1ZOQ (3D)        2O61 (3D)        2O6G (3D)    
Secondary accessions: A8K7L2 Q5FBY1 Q5FBY2 Q5FBY4 Q7Z5G6
Alternative splicing: 5 isoforms:  Q14653-1   Q14653-2   Q14653-3   Q14653-4   Q14653-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IRF3: NX_Q14653

Explore proteomics data for IRF3 at MOPED

Post-translational modifications: 

  • Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated in
    response of induction by IKBKE and TBK1. Phosphorylated at Ser-396 by IKBKE upon ssRNA viral infection. Ser-385
    and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five
    serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection.
    Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E31
  • Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination
    involves TRIM21 leading to proteasomal degradation1
  • ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by
    disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation1
  • Ubiquitination2 at Lys70
  • Modification sites at PhosphoSitePlus

  • See IRF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001184051.1  NP_001184052.1  NP_001184053.1  NP_001184054.1  NP_001184055.1  NP_001184056.1  NP_001184057.1  NP_001562.1  

    ENSEMBL proteins: 
     ENSP00000310127   ENSP00000470431   ENSP00000468911   ENSP00000471896   ENSP00000366344  
     ENSP00000469113   ENSP00000470436   ENSP00000471358   ENSP00000472601   ENSP00000472700  
     ENSP00000470512   ENSP00000470069   ENSP00000472582   ENSP00000473128   ENSP00000472223  
     ENSP00000469067   ENSP00000471517   ENSP00000471402   ENSP00000473176   ENSP00000470140  
     ENSP00000473232   ENSP00000470905   ENSP00000366339   ENSP00000400378  
    Reactome Protein details: Q14653

    IRF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IRF3
    OriGene Protein Over-expression Lysate for IRF3
    OriGene MassSpec for IRF3
    OriGene Custom Protein Services for IRF3
    GenScript Custom Purified and Recombinant Proteins Services for IRF3
    Novus Biologicals IRF3 Proteins
    Novus Biologicals IRF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IRF3
    Cloud-Clone Corp. Proteins for IRF3

    IRF3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRF3
    R&D Systems Antibodies for IRF3
    Cell Signaling Technology (CST) Antibodies for IRF3 
    OriGene Antibodies for IRF3
    OriGene Custom Antibody Services for IRF3
    Novus Biologicals IRF3 Antibodies
    Abcam antibodies for IRF3
    Cloud-Clone Corp. Antibodies for IRF3
    ThermoFisher Antibodies for IRF3
    LSBio Antibodies in human, mouse, rat for IRF3

    IRF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IRF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRF3
    Cloud-Clone Corp. CLIAs for IRF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR008984 SMAD_FHA_domain
     IPR019817 Interferon_reg_fac_CS
     IPR019471 Interferon_reg_factor-3
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q14653

    ProtoNet protein and cluster: Q14653

    1 Blocks protein domain: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    IRF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRF3_HUMAN, Q14653
    Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a
    critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I
    IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response
    element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha
    (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an
    inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or
    toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational
    change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP)
    to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG
    genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in
    primary macrophages
    Enzyme regulation: In the absence of viral infection, maintained as a monomer in an autoinhibited state and
    phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization
    activities and its nuclear localization where it can activate type I IFN and ISG genes

         Genatlas biochemistry entry for IRF3:
    interferon regulatory factor 3

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding ----
    GO:0003677DNA binding NAS12062447
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003712transcription cofactor activity TAS8524823
    GO:0005515protein binding IPI15841462
         
    IRF3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IRF3:
     Big cells  Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irf3):
     cellular  homeostasis/metabolism  immune system 

    IRF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bcl2l12/Irf3Bcl2l12/tm1Ttg for IRF3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRF3

    miRNA
    Products:
        
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IRF3
    Predesigned siRNA for gene silencing in human, mouse, rat IRF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRF3

    Clone
    Products:
         
    OriGene clones in human, mouse for IRF3 (see all 23)
    OriGene ORF clones in mouse, rat for IRF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): IRF3 (NM_001571)
    Sino Biological Human cDNA Clone for IRF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF3

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IRF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRF3_HUMAN, Q14653: Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export
    being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion4
    endoplasmic reticulum1
    endosome1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17079289
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    IRF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRF3 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Regulation of innate immune responses to cytosolic DNA0.00
    Cytosolic sensors of pathogen-associated DNA0.38
    LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production0.00
    Cytosolic DNA-sensing pathway0.33
    STING mediated induction of host immune responses0.00
    IRF3 mediated activation of type 1 IFN0.00
    IRF3-mediated induction of type I IFN0.00
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    Negative regulators of RIG-I/MDA5 signaling0.42
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    4NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33
    NOD-like Receptor Signaling Pathways0.58
    5Interferon Signaling
    Interferon Signaling0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.59
    Interferon gamma signaling0.41
    ISG15 antiviral mechanism0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IRF3
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IRF3
        Toll-Like Receptors Pathway
    TLR-TRIF Pathway

    1 Cell Signaling Technology (CST) Pathway for IRF3
        NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for IRF3
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    3 BioSystems Pathways for IRF3
        Apoptosis
    Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway


    Selected Reactome Pathways for IRF3 (see all 12)
        LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
    Interferon alpha/beta signaling
    Interferon gamma signaling
    TRAF3-dependent IRF activation pathway
    TRAF6 mediated IRF7 activation


    Selected Kegg Pathways  (Kegg details for IRF3) (see all 11):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Pertussis
    Hepatitis C


    IRF3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF3 (see all 7): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRF3 (Q146531, 2, 3 ENSP000003101274) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-2650369,EBI-356402 MINT-6948128 MINT-5208352 MINT-5208538 MINT-5208380 I2D: score=5 STRING: ENSP00000329967
    CREBBPQ927931, 2, 3, ENSP000002623674EBI-2650369,EBI-81215 MINT-6540731 I2D: score=7 STRING: ENSP00000262367
    BAXQ078122, 3, ENSP000002932884MINT-7900391 I2D: score=2 STRING: ENSP00000293288
    MAFBQ9Y5Q31, 3, ENSP000003624104EBI-2650369,EBI-3649340 I2D: score=2 STRING: ENSP00000362410
    GSSP486372, 3, ENSP000002169514MINT-6540711 I2D: score=1 STRING: ENSP00000216951
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS8524823

    IRF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRF3

    Selected Novoseek inferred chemical compound relationships for IRF3 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 81.2 28 20483755 (4), 17449641 (2), 18471880 (2), 19809799 (1) (see all 12)
    rantes 76.6 35 10799898 (4), 12917470 (3), 11390609 (3), 9891032 (3) (see all 18)
    poly(i-c) 76.3 18 19153595 (2), 14982987 (2), 15611223 (1), 17142768 (1) (see all 12)
    ifn-alpha 42.3 1 18941233 (1)
    mdms 41.2 1 17630924 (1)
    retinoic acid 37.3 8 17668876 (1), 16502342 (1), 17540767 (1), 19193783 (1) (see all 5)
    serine 31.9 18 14679297 (2), 9463386 (1), 11846977 (1), 18818394 (1) (see all 12)
    ly294002 25.3 2 16352547 (2)
    inosine monophosphate 15 1 15611223 (1)
    lipid 1.62 2 19637282 (2)



    IRF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IRF3 gene (8 alternative transcripts): 
    NM_001197122.1  NM_001197123.1  NM_001197124.1  NM_001197125.1  NM_001197126.1  NM_001197127.1  NM_001197128.1  NM_001571.5  

    Unigene Cluster for IRF3:

    Interferon regulatory factor 3
    Hs.75254  [show with all ESTs]
    Unigene Representative Sequence: NR_045568
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000599680 ENST00000309877(uc002poy.2 uc002poz.1) ENST00000600911
    ENST00000596822 ENST00000601291 ENST00000377139(uc002pow.3 uc021uxo.1 uc002pou.3 uc010end.2 uc021uxp.1 uc021uxq.1 uc002pot.2 uc021uxr.1 uc021uxs.1 uc010ene.1)
    ENST00000597198 ENST00000596644 ENST00000597636 ENST00000599223 ENST00000593922
    ENST00000600022 ENST00000596765 ENST00000599144 ENST00000598808 ENST00000596756
    ENST00000602190 ENST00000598108
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    GenScript: all cDNA clones in your preferred vector (see all 8): IRF3 (NM_001571)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF3
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat IRF3

    Additional mRNA sequence: 

    AB102886.1 AB102887.1 AK292027.1 AK314421.1 BC000660.2 BC009395.2 BC071721.1 HM357932.1 
    HM357933.1 HM357934.1 HM357935.1 HM357936.1 HM357937.1 NR_045568.1 Z56281.1 

    21 DOTS entries:

    DT.453528  DT.100845708  DT.91753642  DT.100845696  DT.121474245  DT.451839  DT.121474205  DT.95367403 
    DT.100845699  DT.91753653  DT.121474235  DT.102841637  DT.91753635  DT.97810033  DT.100835379  DT.91753634 
    DT.97771645  DT.100035332  DT.100845693  DT.91869957  DT.95367398 

    Selected AceView cDNA sequences (see all 347):

    CR613940 CR596241 BQ050282 CA439235 CR608119 BM828484 BE254144 AI439577 
    CA306422 CR624964 AW337954 AW438775 BM672036 AI520724 BX280211 CF128161 
    BE076293 BM856596 CA434911 BE272560 CA488639 BU741230 H92907 BI771452 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IRF3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                    -                             -                 -     -                           
    SP2:                    -                             -     -     -     -     -                           
    SP3:                                                  -                                                   
    SP4:                                                                                                      
    SP5:                    -     -                                                                           


    ECgene alternative splicing isoforms for IRF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGCCTCC
    IRF3 Expression
    About this image


    IRF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    IRF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75254

    UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653
    Tissue specificity: Expressed constitutively in a variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF3 (see all 7): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IRF3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf31 , 5 interferon regulatory factor 31, 5 76.98(n)1
    72.42(a)1
      7 (29.07 cM)5
    541311  NM_016849.41  NP_058545.11 
     449976485 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004937801 interferon regulatory factor 3-like 48.46(n)
    38.78(a)
      100493780  XM_002940242.2  XP_002940288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii irf31 interferon regulatory factor 3 44.89(n)
    35.2(a)
      564854  NM_001143904.1  NP_001137376.1 


    ENSEMBL Gene Tree for IRF3 (if available)
    TreeFam Gene Tree for IRF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRF3 gene
    IRF82  IRF22  IRF52  IRF42  IRF92  IRF12  IRF72  IRF62  
    7 SIMAP similar genes for IRF3 using alignment to 21 protein entries:     IRF3_HUMAN (see all proteins):
    IRF9    IRF8    IRF1    IRF5    IRF4    IRF2
    IRF7

    IRF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRF3 (see all 270)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58284081,2
    C--50163285(+) CACAC-/A/AC/ACACA/ACACA
    CACCCACCCAC
    /CAC/CC
    CCCCT
    17 -- int1 cds11NA 2
    rs1834482241,2
    --50339517(+) CTTTGC/TGCCTC 9 -- int10--------
    rs1385249831,2
    --50339725(+) AACACC/GAGACA 9 -- int10--------
    rs2016933571,2
    C--50339786(+) ACAGGC/GGGGTT 10 P ut31 syn10--------
    rs1999208691,2
    C--50339811(+) AGGAGC/TGAGGG 10 H R ut31 mis11Minor allele frequency- T:0.01EU 155
    rs2011774121,2
    --50339812(+) GGAGCA/GAGGGC 10 R C ut31 mis10--------
    rs72511,2,,4
    C,F,A,H--50339822(-) GGAGAG/CCTGAG 17 /T /S /D /E mis126Minor allele frequency- C:0.46MN NA NS EA WA CSA EU 6214
    rs1414907681,2
    C,F--50339866(+) TCCTGC/TAGGTA 17 L T A syn1 mis12Minor allele frequency- T:0.00NA EU 5081
    rs1498429901,2
    C,F--50339887(+) TGGTCG/AGAGGT 17 /S /R /* syn1 stg11Minor allele frequency- A:0.00NA 4546
    rs115548331,2
    C,F--50339893(-) TCCCTC/TACCTC 17 L H Y syn1 mis1 ese37Minor allele frequency- T:0.01MN WA NA 5076

    HapMap Linkage Disequilibrium report for IRF3 (50162826 - 50169132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IRF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912269CNV Loss21882294
    dgv3973n71CNV Loss21882294
    dgv3972n71CNV Loss21882294
    nsv828578CNV Loss20364138
    nsv470150CNV Gain18288195
    nsv833864CNV Gain17160897
    nsv817854CNV Gain17921354
    nsv9739CNV Gain+Loss18304495
    nsv833865CNV Gain+Loss17160897
    nsv469715CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRF3
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603734    OMIM disorders: --

    Selected diseases for IRF3 (see all 42):    
    About MalaCards
    hantavirus pulmonary syndrome    newcastle disease    west nile virus    lymphocytic choriomeningitis
    stomatitis    primary effusion lymphoma    herpes simplex    severe acute respiratory syndrome
    rabies    biliary atresia    vaccinia    hepatitis c virus
    influenza    hepatitis b virus infection    measles    cytomegalovirus infection
    hepatitis c    kaposi's sarcoma    pertussis    hepatitis b

    1 disease from the University of Copenhagen DISEASES database for IRF3:
    Melanoma

    IRF3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IRF3 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 78.9 106 11867762 (3), 10729153 (3), 9463386 (2), 16751392 (2) (see all 70)
    rna virus infections 63.8 2 17468758 (1), 19193783 (1), 19265157 (1)
    vesicular stomatitis 61.6 5 17617610 (2), 19152337 (1), 17626075 (1)
    necrosis 33.1 4 18450748 (1), 19759006 (1), 17328045 (1), 19637282 (1)
    newcastle disease 31.2 2 19108859 (1)
    hepatitis c 30.9 6 18203148 (2), 17668876 (1), 19625408 (1), 15709037 (1) (see all 5)
    melanoma 29.4 9 17761676 (1), 17114474 (1), 19690333 (1), 19120474 (1) (see all 6)
    herpes simplex 28.5 3 12917470 (1), 17215277 (1), 16603509 (1)
    inflammation 12.5 3 16911361 (1), 16513254 (1)
    tumors 12 9 16513254 (2), 18450748 (1), 19759006 (1), 17328045 (1) (see all 8)

    Genetic Association Database (GAD): IRF3
    Human Genome Epidemiology (HuGE) Navigator: IRF3 (18 documents)

    Export disorders for IRF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRF3 gene, integrated from 10 sources (see all 526):
    (articles sorted by number of sources associating them with IRF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. (PubMed id 8524823)1, 2, 3, 9 Au W.W.-C.... Pitha P.M. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. (PubMed id 10805757)1, 2, 9 Kumar K.P.... Reich N.C. (Mol. Cell. Biol. 2000)
    3. Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. (PubMed id 10920266)1, 2, 9 Suhara W.... Fujita T. (J. Biochem. 2000)
    4. Crystal structure of IRF-3 in complex with CBP. (PubMed id 16154084)1, 2, 9 Qin B.Y....Lin K. (Structure 2005)
    5. [Relationship between polymorphism of IRF-3 gene codon 427 and esophageal cancer in Anyang population of China]. (PubMed id 15303122)1, 4, 9 Zhang C.F....Ke Y. (Beijing Da Xue Xue Bao 2004)
    6. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. (PubMed id 14555996)1, 2, 9 Qin B.Y.... Lin K. (Nat. Struct. Biol. 2003)
    7. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. (PubMed id 18711448)1, 2, 9 Zhang M.... Shu H.B. (Cell Res. 2008)
    8. Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. (PubMed id 16846591)1, 2, 9 Solis M.... Hiscott J. (Biochem. Pharmacol. 2006)
    9. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (J. Biol. Chem. 2004)
    10. HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. (PubMed id 11314014)1, 2, 9 Lin R....Hiscott J. (Oncogene 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3661 HGNC: 6118 AceView: IRF3 Ensembl:ENSG00000126456 euGenes: HUgn3661
    ECgene: IRF3 Kegg: 3661 H-InvDB: IRF3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IRF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IRF3 gene:
    Search GeneIP for patents involving IRF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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