IRF3 Gene
protein-coding GIFtS: 66
GCID: GC19M050162
|
|
interferon regulatory factor 3
| |
Aliases
for IRF3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon Regulatory Factor 31 2 | | IRF-33 |
Export aliases for IRF3 gene to outside databasesPrevious GC identifers: GC19M050821 GC19M050530 GC19M054838 GC19M054854 GC19M046539 |
Summaries
for IRF3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IRF3:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is foundin an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complextranslocates to the nucleus and activates the transcription of interferons alpha and beta, as well as otherinterferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed forthis gene. (provided by RefSeq, Nov 2011)
UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical rolein the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alphaand IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in theirpromoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays acritical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in thecytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR)signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to itsdimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activatedfactor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinctgene expression programs in macrophages and can induce significant apoptosis in primary macrophages
Gene Wiki entry for IRF3
|
Genomic Views
for IRF3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRF3 gene promoter:
STAT1 AP-1 p53 ATF-2 p300 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRF3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q13.4IRF3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M050162: view genomic region
(about GC identifiers)
Start:
|
50,162,829 bp from pter |
End:
|
50,169,132 bp from pter |
Size:
|
6,304 bases |
Orientation:
|
minus strand |
|
Proteins
for IRF3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653 (See
protein sequence)Recommended Name: Interferon regulatory factor 3 Size: 427 amino acids; 47219 Da
Subunit: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact withMAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (viaC-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interactswith TRIM21. Interacts with HERC5
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export beingthe prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm
6/9 PDB 3D structures from  and Proteopedia  for IRF3 (see all 9):1J2F (3D)
1QWT (3D)
1T2K (3D)
1ZOQ (3D)
2O61 (3D)
2O6G (3D)
Secondary accessions: A8K7L2 Q5FBY1Alternative splicing: 2 isoforms: Q14653-1 Q14653-2 Explore the universe of human proteins at neXtProt for IRF3: NX_Q14653
Post-translational modifications:
Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated inresponse of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response toinduction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylatedin response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virusprotein E31
Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitinationinvolves TRIM21 leading to proteasomal degradation1
ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disruptingPIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14653
IRF3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001184051.1 NP_001184052.1 NP_001184053.1 NP_001184054.1 NP_001184055.1 NP_001184056.1 NP_001184057.1 NP_001562.1
ENSEMBL proteins: ENSP00000366344 ENSP00000310127 ENSP00000366339 ENSP00000400378 Reactome Protein details: Q14653
Human Recombinant Protein Products for IRF3:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
IRF3 for ontologies About GeneDecksing
IRF3 Antibody Products:
Assay Products for IRF3: |
Protein
Domains /
Families
for IRF3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IRF3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q14653ProtoNet protein and cluster: Q14653 1 Blocks protein family: IPB001346 Interferon regulatory factor
UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653Similarity: Belongs to the IRF familySimilarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain |
Function
for IRF3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IRF3_HUMAN, Q14653Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical rolein the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alphaand IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in theirpromoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays acritical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in thecytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR)signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to itsdimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activatedfactor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinctgene expression programs in macrophages and can induce significant apoptosis in primary macrophagesEnzyme regulation: In the absence of viral infection, maintained as a monomer in an autoinhibited state andphosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activitiesand its nuclear localization where it can activate type I IFN and ISG genes Genatlas biochemistry entry for IRF3:interferon regulatory factor 3
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
IRF3 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for IRF3:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Irf3):
IRF3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Bcl2l12/Irf3Bcl2l12/tm1Ttg for IRF3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF3 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 8): IRF3 (NM_001571) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF3 |
|
Pathways & Interactions
for IRF3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Toll-like receptor signaling pathway | | | 3 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 4 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 5 | Cytokine Signaling in Immune system | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for IRF3
1  R&D Systems Pathway for IRF3
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRF3
1 
Cell Signaling Technology (CST) Pathway for IRF3
1  GeneGo (Thomson Reuters) Pathway for IRF3
2  BioSystems Pathways for IRF3
5/26 
Reactome Pathways for IRF3 (see all 26)
5/7 
Kegg Pathways (Kegg details for IRF3) (see all 7):
IRF3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/131 Interacting proteins for IRF3 (Q146531, 2, 3 ENSP000003101274) via UniProtKB, MINT, STRING, and/or I2D (see all 131)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TBK1 | Q9UHD21, 2, 3, ENSP000003299674 | EBI-2650369,EBI-1383470 MINT-6948128 MINT-5208352 MINT-5208538 MINT-5208380 I2D:
score=5 STRING: ENSP00000329967 | | CREBBP | Q927931, 2, 3, ENSP000002623674 | EBI-2650369,EBI-81215 MINT-6540731 I2D:
score=7 STRING: ENSP00000262367 | | BAX | Q078122, 3, ENSP000002932884 | MINT-7900391 I2D:
score=2 STRING: ENSP00000293288 | | MAFB | Q9Y5Q31, 3, ENSP000003624104 | EBI-2650369,EBI-3649340 I2D:
score=2 STRING: ENSP00000362410 | | GSS | P486372, 3, ENSP000002169514 | MINT-6540711 I2D:
score=1 STRING: ENSP00000216951 |
About this table
Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 8524823 | | GO:0006917 | induction of apoptosis |
TAS | -- | | GO:0006974 | response to DNA damage stimulus |
TAS | 16979567 |
IRF3 for ontologies About GeneDecksing
|
Drugs & Compounds
for IRF3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IRF3 for compounds About GeneDecksing
 Browse Tocris compounds for IRF3
10/17 Novoseek chemical compound relationships for IRF3 gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| polyinosinic-polycytidylic acid |
81.2 |
28 |
20483755 (4), 17449641 (2), 18471880 (2), 19809799 (1) (see all 12) |
| rantes |
76.6 |
35 |
10799898 (4), 12917470 (3), 11390609 (3), 9891032 (3) (see all 18) |
| poly(i-c) |
76.3 |
18 |
19153595 (2), 14982987 (2), 15611223 (1), 17142768 (1) (see all 12) |
| ifn-alpha |
42.3 |
1 |
18941233 (1) |
| mdms |
41.2 |
1 |
17630924 (1) |
| retinoic acid |
37.3 |
8 |
17668876 (1), 16502342 (1), 17540767 (1), 19193783 (1) (see all 5) |
| serine |
31.9 |
18 |
14679297 (2), 9463386 (1), 11846977 (1), 18818394 (1) (see all 12) |
| ly294002 |
25.3 |
2 |
16352547 (2) |
| inosine monophosphate |
15 |
1 |
15611223 (1) |
| lipid |
1.62 |
2 |
19637282 (2) |
Search CenterWatch for drugs/clinical trials and news about IRF3
|
Transcripts
for IRF3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRF3 gene (8 alternative transcripts): NM_001197122.1 NM_001197123.1 NM_001197124.1 NM_001197125.1 NM_001197126.1 NM_001197127.1 NM_001197128.1 NM_001571.5 Unigene Clusters for IRF3: Interferon regulatory factor 3 Hs.75254 [show with all ESTs], Hs.731922 [show with all ESTs]Unigene Representative Sequences: NR_045568, BQ0730064 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377139(uc002pow.3 uc021uxo.1 uc002pou.3 uc010end.2 uc021uxp.1 uc021uxq.1 uc002pot.2 uc021uxr.1 uc021uxs.1 uc010ene.1)
ENST00000309877(uc002poy.2 uc002poz.1) ENST00000377135 ENST00000442265
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF3 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 8): IRF3 (NM_001571) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF3 |
Additional cDNA sequence: AB102884.1 23 DOTS entries: DT.453528 DT.91753642 DT.100845708 DT.100845696 DT.91753635 DT.121474245 DT.91753634 DT.451839 DT.121474205 DT.95367403 DT.100845699 DT.91753653 DT.121474235 DT.102841637 DT.97810033 DT.100039346 DT.100835379 DT.91753644 DT.97771645 DT.100035332 DT.100845693 DT.91869957 DT.95367398 24/347 AceView cDNA sequences (see all 347): CR615920 BU526871 BU955963 AU119609 BQ050282 CD368614 BC000660 CR608119 BQ227399 BE272560 BM726964 CA306422 BQ270669 BI771452 BM856596 BM820436 BM452967 BM820364 CR624964 AI520724 AW572573 AK057577 H92907 Z56281
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IRF3 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IRF3
|
Expression
for IRF3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGCCTCC
About this image
See IRF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRF3
SOURCE GeneReport for Unigene clusters: Hs.75254 Hs.731922
UniProtKB/Swiss-Prot: IRF3_HUMAN, Q14653Tissue specificity: Expressed constitutively in a variety of tissues
SABiosciences Expression via Pathway-Focused PCR Arrays including IRF3 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF3 |
Orthologs
for IRF3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IRF3 gene from 2/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
IRF36 |
-- |
37(a) |
1 ↔ 1 |
6(80617109-80632227) |
zebrafish
(Danio rerio) |
Actinopterygii |
irf31 |
interferon regulatory factor 3 |
44.89(n)
35.2(a) |
|
564854 NM_001143904.1 NP_001137376.1 |
ENSEMBL Gene Tree for IRF3 (if available)
TreeFam Gene Tree for IRF3 (if available) |
Paralogs
for IRF3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IRF3 gene
- IRF82 IRF22 IRF52 IRF42 IRF92 IRF12 IRF62 IRF72
6 SIMAP similar genes for IRF3 using alignment to 24 protein entries: IRF3_HUMAN (see all proteins):IRF4 IRF9 IRF8 IRF5 IRF7 IRF2
IRF3 for paralogs About GeneDecksing
|
Genomic Variants
for IRF3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRF3 (50162829 - 50169132 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for IRF3
6 CNVs: 30912 2246 5112 9803 5113 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF3 |
|
Disorders
/ Diseases
for IRF3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRF3 for disorders About GeneDecksing
OMIM gene information: 603734
OMIM disorders: --
20/39  diseases for IRF3 (see all 39): About MalaCardswest nile virus hantavirus pulmonary syndrome severe acute respiratory syndrome newcastle disease
primary effusion lymphoma lymphocytic choriomeningitis herpes simplex biliary atresia
systemic lupus erythematosus lupus erythematosus cytomegalovirus infection rheumatoid arthritis
hepatitis c stomatitis kaposi's sarcoma bronchiolitis
multiple sclerosis influenza lung cancer hepatitis b
1 disease from the University of Copenhagen DISEASES database for IRF3:Melanoma 10/21 Novoseek disease relationships for IRF3 gene (see all 21) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| virus infection |
78.9 |
106 |
11867762 (3), 10729153 (3), 9463386 (2), 16751392 (2) (see all 70) |
| rna virus infections |
63.8 |
2 |
17468758 (1), 19193783 (1), 19265157 (1) |
| vesicular stomatitis |
61.6 |
5 |
17617610 (2), 19152337 (1), 17626075 (1) |
| necrosis |
33.1 |
4 |
18450748 (1), 19759006 (1), 17328045 (1), 19637282 (1) |
| newcastle disease |
31.2 |
2 |
19108859 (1) |
| hepatitis c |
30.9 |
6 |
18203148 (2), 17668876 (1), 19625408 (1), 15709037 (1) (see all 5) |
| melanoma |
29.4 |
9 |
17761676 (1), 17114474 (1), 19690333 (1), 19120474 (1) (see all 6) |
| herpes simplex |
28.5 |
3 |
12917470 (1), 17215277 (1), 16603509 (1) |
| inflammation |
12.5 |
3 |
16911361 (1), 16513254 (1) |
| tumors |
12 |
9 |
16513254 (2), 18450748 (1), 19759006 (1), 17328045 (1) (see all 8) |
Genetic Association Database (GAD): IRF3
Human Genome Epidemiology (HuGE) Navigator: IRF3 (18 documents)
Export disorders for IRF3 gene to outside databases
|
Publications
for IRF3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRF3 gene, integrated from 9 sources (see all 498):
(articles sorted by number of sources associating them with IRF3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. (PubMed id 8524823)1, 2, 3, 9 Au W.W.-C.... Pitha P.M. (1995)
- Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. (PubMed id 10805757)1, 2, 9 Kumar K.P.... Reich N.C. (2000)
- Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300. (PubMed id 10920266)1, 2, 9 Suhara W.... Fujita T. (2000)
- Crystal structure of IRF-3 in complex with CBP. (PubMed id 16154084)1, 2, 9 Qin B.Y....Lin K. (2005)
- [Relationship between polymorphism of IRF-3 gene codon 427 and esophageal cancer in Anyang population of China] (PubMed id 15303122)1, 4, 9 Zhang C.F....Ke Y. (2004)
- Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. (PubMed id 14555996)1, 2, 9 Qin B.Y.... Lin K. (2003)
- Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. (PubMed id 18711448)1, 2, 9 Zhang M....Shu H.B. (2008)
- Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. (PubMed id 16846591)1, 2, 9 Solis M....Hiscott J. (2006)
- Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (2004)
- Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. (PubMed id 9803267)1, 2, 9 Bellingham J.... Gregory-Evans C.Y. (1998)
|
External Searches for IRF3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing IRF3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing IRF3 gene
(According to HUGE)
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| -- |
Specialized Databases showing IRF3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for IRF3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IRF3 gene:
Search GeneIP for patents involving IRF3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IRF3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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