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Aliases for IRF2BPL Gene

Aliases for IRF2BPL Gene

  • Interferon Regulatory Factor 2 Binding Protein-Like 2 3
  • C14orf4 3 4 6
  • EAP1 3 4 6
  • Enhanced At Puberty Protein 1 3 4
  • Enhanced At Puberty 1 2 3
  • Interferon Regulatory Factor 2-Binding Protein-Like 3
  • Chromosome 14 Open Reading Frame 4 2
  • KIAA1865 4

External Ids for IRF2BPL Gene

Previous HGNC Symbols for IRF2BPL Gene

  • C14orf4

Previous GeneCards Identifiers for IRF2BPL Gene

  • GC14M077491

Summaries for IRF2BPL Gene

Entrez Gene Summary for IRF2BPL Gene

  • This gene encodes a transcription factor that may play a role in regulating female reproductive function. [provided by RefSeq, Jun 2012]

GeneCards Summary for IRF2BPL Gene

IRF2BPL (Interferon Regulatory Factor 2 Binding Protein-Like) is a Protein Coding gene. An important paralog of this gene is IRF2BP2.

UniProtKB/Swiss-Prot for IRF2BPL Gene

  • May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.

Gene Wiki entry for IRF2BPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF2BPL Gene

Genomics for IRF2BPL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRF2BPL Gene

Start:
77,024,543 bp from pter
End:
77,028,699 bp from pter
Size:
4,157 bases
Orientation:
Minus strand

Genomic View for IRF2BPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF2BPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2BPL Gene

No data available for Regulatory Elements for IRF2BPL Gene

Proteins for IRF2BPL Gene

  • Protein details for IRF2BPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1B7-I2BPL_HUMAN
    Recommended name:
    Interferon regulatory factor 2-binding protein-like
    Protein Accession:
    Q9H1B7
    Secondary Accessions:
    • Q8NDQ2
    • Q96JG2
    • Q9H3I7

    Protein attributes for IRF2BPL Gene

    Size:
    796 amino acids
    Molecular mass:
    82659 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47494.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IRF2BPL Gene

neXtProt entry for IRF2BPL Gene

Proteomics data for IRF2BPL Gene at MOPED

Post-translational modifications for IRF2BPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF2BPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRF2BPL Gene

Domains for IRF2BPL Gene

Protein Domains for IRF2BPL Gene

Suggested Antigen Peptide Sequences for IRF2BPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H1B7

UniProtKB/Swiss-Prot:

I2BPL_HUMAN :
  • Q9H1B7
Family:
  • Belongs to the IRF2BP family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with IRF2BPL: view

No data available for Gene Families for IRF2BPL Gene

Function for IRF2BPL Gene

Molecular function for IRF2BPL Gene

UniProtKB/Swiss-Prot Function:
May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.

Gene Ontology (GO) - Molecular Function for IRF2BPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IRF2BPL: view

Phenotypes for IRF2BPL Gene

GenomeRNAi human phenotypes for IRF2BPL:
genes like me logo Genes that share phenotypes with IRF2BPL: view

Animal Model Products

CRISPR Products

miRNA for IRF2BPL Gene

miRTarBase miRNAs that target IRF2BPL

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRF2BPL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IRF2BPL Gene

Localization for IRF2BPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2BPL Gene

Gene Ontology (GO) - Cellular Components for IRF2BPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus NAS 11095982
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with IRF2BPL: view

No data available for Subcellular locations from COMPARTMENTS for IRF2BPL Gene

Pathways for IRF2BPL Gene

SuperPathways for IRF2BPL Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IRF2BPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17627301
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 17627301
GO:0046543 development of secondary female sexual characteristics ISS 17627301
genes like me logo Genes that share ontologies with IRF2BPL: view

No data available for Pathways by source for IRF2BPL Gene

Transcripts for IRF2BPL Gene

mRNA/cDNA for IRF2BPL Gene

(83) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRF2BPL Gene

Interferon regulatory factor 2 binding protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRF2BPL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2BPL Gene

No ASD Table

Relevant External Links for IRF2BPL Gene

GeneLoc Exon Structure for
IRF2BPL
ECgene alternative splicing isoforms for
IRF2BPL

Expression for IRF2BPL Gene

mRNA expression in normal human tissues for IRF2BPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRF2BPL Gene

SOURCE GeneReport for Unigene cluster for IRF2BPL Gene Hs.179260

mRNA Expression by UniProt/SwissProt for IRF2BPL Gene

Q9H1B7-I2BPL_HUMAN
Tissue specificity: Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in brain, kidney, liver, testis, thyroid gland and lymphocytes.
genes like me logo Genes that share expressions with IRF2BPL: view

Expression partners for IRF2BPL Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for IRF2BPL Gene

Orthologs for IRF2BPL Gene

This gene was present in the common ancestor of animals.

Orthologs for IRF2BPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IRF2BPL 35
  • 92.03 (n)
  • 97.93 (a)
IRF2BPL 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF2BPL 35
  • 93.76 (n)
  • 99.42 (a)
IRF2BPL 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf2bpl 35
  • 87.98 (n)
  • 97.03 (a)
Irf2bpl 16
Irf2bpl 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IRF2BPL 35
  • 99.15 (n)
  • 99.87 (a)
IRF2BPL 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf2bpl 35
  • 88.49 (n)
  • 97.06 (a)
oppossum
(Monodelphis domestica)
Mammalia IRF2BPL 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves C14ORF4 35
  • 80.49 (n)
  • 85.74 (a)
IRF2BPL 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irf2bpl 35
  • 66.82 (n)
  • 76.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69079 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28844 35
irf2bpl 35
  • 71.4 (n)
  • 79.17 (a)
irf2bpl 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8814 35
fruit fly
(Drosophila melanogaster)
Insecta CG11138 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-260 36
  • 27 (a)
OneToMany
Species with no ortholog for IRF2BPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IRF2BPL Gene

ENSEMBL:
Gene Tree for IRF2BPL (if available)
TreeFam:
Gene Tree for IRF2BPL (if available)

Paralogs for IRF2BPL Gene

Paralogs for IRF2BPL Gene

Selected SIMAP similar genes for IRF2BPL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRF2BPL: view

Variants for IRF2BPL Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IRF2BPL Gene

Q9H1B7-I2BPL_HUMAN
The poly-Gln region is polymorphic; the most frequent allele contained 24 Gln. Stretches of 20-31 Gln are observed in healthy individuals

Sequence variations from dbSNP and Humsavar for IRF2BPL Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs205811 -- 77,029,001(+) CTGCC(C/G)GGCAT upstream-variant-2KB
rs205812 -- 77,029,543(+) TGATA(C/T)ATTTT upstream-variant-2KB
rs205813 -- 77,030,276(+) AGGTT(A/G)TTAGG upstream-variant-2KB
rs879027 -- 77,026,548(+) AATTC(A/G)TAGTC reference, synonymous-codon
rs888244 -- 77,028,032(+) CACCT(C/G)CTACT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IRF2BPL Gene

Variant ID Type Subtype PubMed ID
nsv902103 CNV Loss 21882294
nsv510384 CNV Loss 20534489

Relevant External Links for IRF2BPL Gene

HapMap Linkage Disequilibrium report
IRF2BPL

Disorders for IRF2BPL Gene

No disorders were found for IRF2BPL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IRF2BPL Gene

Publications for IRF2BPL Gene

  1. Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. (PMID: 17627301) Heger S. … Ojeda S.R. (J. Clin. Invest. 2007) 2 3 4
  2. Characterization of C14orf4, a novel intronless human gene containing a polyglutamine repeat, mapped to the ARVD1 critical region. (PMID: 11095982) Rampazzo A. … Danieli G.A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for IRF2BPL Gene

Sources for IRF2BPL Gene

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