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IRF2BPL Gene

protein-coding   GIFtS: 47
GCID: GC14M077491

Interferon Regulatory Factor 2 Binding Protein-Like

(Previous name: chromosome 14 open reading frame 4)
(Previous symbol: C14orf4)
  Search for IRF2BPL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Regulatory Factor 2 Binding Protein-Like1 2     Enhanced At Puberty Protein 12 3
C14orf41 2 3 5     Chromosome 14 Open Reading Frame 41
EAP12 3 5     Interferon Regulatory Factor 2-Binding Protein-Like2
Enhanced At Puberty 11 2     KIAA18653

External Ids:    HGNC: 142821   Entrez Gene: 642072   Ensembl: ENSG000001196697   OMIM: 6117205   UniProtKB: Q9H1B73   

Export aliases for IRF2BPL gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRF2BPL Gene:
This gene encodes a transcription factor that may play a role in regulating female reproductive function.
(provided by RefSeq, Jun 2012)

GeneCards Summary for IRF2BPL Gene:
IRF2BPL (interferon regulatory factor 2 binding protein-like) is a protein-coding gene. An important paralog of this gene is IRF2BP1.

UniProtKB/Swiss-Prot: I2BPL_HUMAN, Q9H1B7
Function: May contribute to the control of female reproductive function (By similarity). May play a role in gene
transcription by transactivating GNRH1 promoter and repressing PENK promoter

Gene Wiki entry for IRF2BPL (C14orf4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IRF2BPL
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRF2BPL promoter sequence
   Search Chromatin IP Primers for IRF2BPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF2BPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

IRF2BPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF2BPL gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077491:  view genomic region     (about GC identifiers)

Start:
77,490,886 bp from pter      End:
77,495,034 bp from pter
Size:
4,149 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I2BPL_HUMAN, Q9H1B7 (See protein sequence)
Recommended Name: Interferon regulatory factor 2-binding protein-like  
Size: 796 amino acids; 82659 Da
Sequence caution: Sequence=BAB47494.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
2 PDB 3D structures from and Proteopedia for IRF2BPL:
2B9G (3D)        2CS3 (3D)    
Secondary accessions: Q8NDQ2 Q96JG2 Q9H3I7

Explore the universe of human proteins at neXtProt for IRF2BPL: NX_Q9H1B7

Explore proteomics data for IRF2BPL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRF2BPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078772.1  
    ENSEMBL proteins: 
     ENSP00000238647  

    IRF2BPL Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IRF2BPL 

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    IRF2BPL Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IRF2BPL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022750 Interferon_reg_fac2-bd1_2_Znf

    Graphical View of Domain Structure for InterPro Entry Q9H1B7

    ProtoNet protein and cluster: Q9H1B7

    UniProtKB/Swiss-Prot: I2BPL_HUMAN, Q9H1B7
    Similarity: Belongs to the IRF2BP family
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with IRF2BPL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I2BPL_HUMAN, Q9H1B7
    Function: May contribute to the control of female reproductive function (By similarity). May play a role in gene
    transcription by transactivating GNRH1 promoter and repressing PENK promoter

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with IRF2BPL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IRF2BPL:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRF2BPL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRF2BPL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRF2BPL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRF2BPL

    miRNA
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    miRTarBase miRNAs that target IRF2BPL:
    hsa-mir-92a-3p (MIRT049752), hsa-mir-615-3p (MIRT040275), hsa-mir-1 (MIRT005439)

    Block miRNA regulation of human, mouse, rat IRF2BPL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRF2BPL (see all 41):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-99b* hsa-miR-15a hsa-miR-200a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidIRF2BPL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRF2BPL
    Predesigned siRNA for gene silencing in human, mouse, rat IRF2BPL

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IRF2BPL

    Clone
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    GenScript: all cDNA clones in your preferred vector: IRF2BPL (NM_024496)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF2BPL
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRF2BPL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BPL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I2BPL_HUMAN, Q9H1B7: Nucleus (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus NAS11095982

    Find genes that share ontologies with IRF2BPL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including IRF2BPL: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IRF2BPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRF2BPL (Q9H1B72, 3 ENSP000002386474) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2Q1Q7Z7E83, ENSP000002922114I2D: score=2 STRING: ENSP00000292211
    HCKP086313, ENSP000003650124I2D: score=1 STRING: ENSP00000365012
    RBM39Q144983, ENSP000002533634I2D: score=1 STRING: ENSP00000253363
    SUMO1P631652, ENSP000003760764MINT-8173832 STRING: ENSP00000376076
    IRF2P143163, ENSP000003772184I2D: score=1 STRING: ENSP00000377218
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with IRF2BPL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRF2BPL (I2BPL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRF2BPL gene: 
    NM_024496.3  

    Unigene Cluster for IRF2BPL:

    Interferon regulatory factor 2 binding protein-like
    Hs.179260  [show with all ESTs]
    Unigene Representative Sequence: NM_024496
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000238647(uc001xsy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRF2BPL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRF2BPL (see all 41):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-193a-3p hsa-miR-607 hsa-miR-99b* hsa-miR-15a hsa-miR-200a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidIRF2BPL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IRF2BPL
    Predesigned siRNA for gene silencing in human, mouse, rat IRF2BPL
    Clone
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    OriGene ORF clones in mouse, rat for IRF2BPL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRF2BPL (NM_024496)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF2BPL
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRF2BPL
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IRF2BPL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRF2BPL
      QuantiTect SYBR Green Assays in human, mouse, rat IRF2BPL
      QuantiFast Probe-based Assays in human, mouse, rat IRF2BPL

    Additional mRNA sequence: 

    AB058768.1 AF063597.1 AL832320.1 BC042460.1 BC108292.1 BC152431.1 

    4 DOTS entries:

    DT.100691508  DT.100024980  DT.95123233  DT.309713 

    Selected AceView cDNA sequences (see all 83):

    AI083493 CB267231 AI903505 BG697953 NM_024496 BX281978 BG676666 BQ639751 
    AI821525 AI820934 AI821684 AI628627 H62414 BU186019 AA384503 BU165663 
    AB058768 AJ712875 BU634416 CA415462 AI016335 BU580846 AI825159 BQ959333 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRF2BPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAATCTGC
    IRF2BPL Expression
    About this image


    IRF2BPL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    IRF2BPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRF2BPL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179260

    UniProtKB/Swiss-Prot: I2BPL_HUMAN, Q9H1B7
    Tissue specificity: Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in
    brain, kidney, liver, testis, thyroid gland and lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including IRF2BPL: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IRF2BPL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BPL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IRF2BPL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf2bpl1 , 5 RIKEN cDNA 6430527G18 gene5
    interferon regulatory factor 2 binding protein-like1
    87.98(n)1
    97.03(a)1
      12 (41.06 cM)5
    2383301  NM_145836.21  NP_665835.11 
     868807035 
    chicken
    (Gallus gallus)
    Aves C14ORF41 interferon regulatory factor 2 binding protein-like 80.49(n)
    85.74(a)
      429422  XM_426978.4  XP_426978.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690792 hypothetical protein MGC69079 76.38(n)    BC059332.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.288442 Danio rerio cDNA clone MGC73290 IMAGE4787056, complete more 79.69(n)    BC060929.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111386
    --
    27(a)
    1 → many
    X(12463202-12477226)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2606
    Protein TAG-260, isoform a
    27(a)
    1 → many
    V(13370104-13380189) WBGene00010867


    ENSEMBL Gene Tree for IRF2BPL (if available)
    TreeFam Gene Tree for IRF2BPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRF2BPL gene
    IRF2BP12  IRF2BP22  
    1 SIMAP similar gene for IRF2BPL using alignment to 1 protein entry:     I2BPL_HUMAN:
    IRF2BP1

    Find genes that share paralogs with IRF2BPL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    I2BPL_HUMAN, Q9H1B7: The poly-Gln region is polymorphic; the most frequent allele contained 24 Gln. Stretches of 20-31
    Gln are observed in healthy individuals


    Selected SNPs for IRF2BPL (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432009741,2
    C--77490438(+) TGGCA-/GGTTTT 1 -- ds50010--------
    rs1492267531,2
    --77490446(+) TTTGTG/TTTAAA 1 -- ds50010--------
    rs569482701,2
    C,F--77490527(+) CTTGTC/TAAGTC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs585803901,2
    C,F--77490543(+) CTGCAC/TTGGGT 1 -- ds50011Minor allele frequency- T:0.04EA 120
    rs171051801,2
    C,F,H--77490669(+) CGCTTA/CGTCAG 1 -- ds500128Minor allele frequency- N:0.00NA NS EA WA 3388
    rs1151663211,2
    C,F--77490754(+) CCTTTC/GCCACA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1842912011,2
    --77490779(+) GCTTTC/GAAAAG 1 -- ds50010--------
    rs751023931,2
    C,F--77490834(+) TACGTC/GGGAGT 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1389985331,2
    --77490898(+) CAATTA/GAATTT 1 -- ut310--------
    rs725227211,2
    C--77491190(+) AAAAC-/AG/GA 
            
    AACAA
    2 -- ut311CSA 2

    HapMap Linkage Disequilibrium report for IRF2BPL (77490886 - 77495034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IRF2BPL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510384CNV Loss20534489
    nsv902103CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRF2BPL
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF2BPL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611720    OMIM disorders: --


    Find genes that share disorders with IRF2BPL           About GenesLikeMe


    Export disorders for IRF2BPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRF2BPL gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with IRF2BPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. (PubMed id 17627301)1, 2, 3 Heger S.... Ojeda S.R. (J. Clin. Invest. 2007)
    2. Characterization of C14orf4, a novel intronless human gene containing a polyglutamine repeat, mapped to the ARVD1 critical region. (PubMed id 11095982)1, 2, 3 Rampazzo A.... Danieli G.A. (Biochem. Biophys. Res. Commun. 2000)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1 McCormack M....Cavalleri G.L. (Pharmacogenomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 64207 HGNC: 14282 AceView: C14orf4 Ensembl:ENSG00000119669 euGenes: HUgn64207
    ECgene: IRF2BPL H-InvDB: IRF2BPL

    (According to HUGE)
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    HUGE: KIAA1865

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IRF2BPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IRF2BPL gene:
    Search GeneIP for patents involving IRF2BPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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