IRF2BP2 Gene
protein-coding GIFtS: 46
GCID: GC01M234740
|
|
interferon regulatory factor 2 binding protein 2
| |
Aliases
for IRF2BP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon Regulatory Factor 2 Binding Protein 21 2 | | IRF-2BP21 3 | | IRF-2-Binding Protein 22 3 | | Interferon Regulatory Factor 2-Binding Protein 22 |
Export aliases for IRF2BP2 gene to outside databasesPrevious GC identifers: GC01U900151 GC01M231827 GC01M231049 GC01M232806 GC01M205232 |
Summaries
for IRF2BP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IRF2BP2:
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminaltranscriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encodingdistinct isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: I2BP2_HUMAN, Q7Z5L9Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histonedeacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as acoactivator of VEGFA expression in cardiac and skeletal muscle
|
Genomic Views
for IRF2BP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRF2BP2 gene promoter:
HEN1 CREB ISGF-3 Zic1 c-Myb RelA AP-4 NF-kappaB NF-kappaB1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRF2BP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2BP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.3 Ensembl cytogenetic band: 1q42.3 HGNC cytogenetic band: 1q42.3IRF2BP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M234740: view genomic region
(about GC identifiers)
Start:
|
234,740,015 bp from pter |
End:
|
234,745,271 bp from pter |
Size:
|
5,257 bases |
Orientation:
|
minus strand |
|
Proteins
for IRF2BP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I2BP2_HUMAN, Q7Z5L9 (See
protein sequence)Recommended Name: Interferon regulatory factor 2-binding protein 2 Size: 587 amino acids; 61025 Da
Subunit: Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B1AM35 B1AM36 Q6P083 Q7Z5L8 Q8N351 Q8WUH8Alternative splicing: 3 isoforms: Q7Z5L9-1 Q7Z5L9-2 Q7Z5L9-3 Explore the universe of human proteins at neXtProt for IRF2BP2: NX_Q7Z5L9
Post-translational modifications:
Phosphorylation at Ser-360 is required for nuclear targeting1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z5L9
IRF2BP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001070865.1 NP_892017.2
ENSEMBL proteins: ENSP00000355569 ENSP00000355568
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IRF2BP2 for ontologies About GeneDecksing
IRF2BP2 Antibody Products:
Assay Products for IRF2BP2: |
Protein
Domains /
Families
for IRF2BP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IRF2BP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z5L9ProtoNet protein and cluster: Q7Z5L9 UniProtKB/Swiss-Prot: I2BP2_HUMAN, Q7Z5L9Domain: The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2Similarity: Belongs to the IRF2BP familySimilarity: Contains 1 RING-type zinc finger |
Function
for IRF2BP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: I2BP2_HUMAN, Q7Z5L9Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histonedeacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as acoactivator of VEGFA expression in cardiac and skeletal muscle
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP2 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
IRF2BP2 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for IRF2BP2:
|
Pathways & Interactions
for IRF2BP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF2BP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/29 Interacting proteins for IRF2BP2 (Q7Z5L93 ENSP000003555684) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
IRF2BP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for IRF2BP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IRF2BP2
Search CenterWatch for drugs/clinical trials and news about IRF2BP2 / I2BP2
|
Transcripts
for IRF2BP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRF2BP2 gene (2 alternative transcripts): NM_001077397.1 NM_182972.2 Unigene Cluster for IRF2BP2: Interferon regulatory factor 2 binding protein 2 Hs.350268 [show with all ESTs]Unigene Representative Sequence: NM_1829723 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366610(uc009xfw.3 uc001hwf.3) ENST00000366609(uc001hwg.3)
ENST00000491430
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IRF2BP2 (NM_182972) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF2BP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2BP2 |
Additional cDNA sequence: AK054864.1 AK056930.1 AK299768.1 AK300375.1 AK309579.1 AY278023.1 AY278024.1 BC020516.1 BC041989.1 BC053539.1 BC065759.1 20 DOTS entries: DT.95219517 DT.100826114 DT.454220 DT.95092639 DT.95182970 DT.100741176 DT.91763956 DT.95093418 DT.91763967 DT.100826113 DT.100826110 DT.75173873 DT.121458712 DT.95201928 DT.95201922 DT.95201947 DT.95299545 DT.97792464 DT.99989440 DT.100044512 24/380 AceView cDNA sequences (see all 380): BM996263 BU069045 CA841938 BQ878908 BM470390 BQ000828 CA848152 CA848431 BE502055 AI915051 AW195352 AA298477 CA439551 BM828106 BI258477 CR600231 BU069973 AW302352 AW236608 BM828644 AI336772 BU675168 CD674626 AA764910
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for IRF2BP2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | - | | - | | | | | | |
| SP2: | | | | | - | | | | | | |
| SP3: | | | | | | | | | | |
ECgene alternative splicing isoforms for IRF2BP2
|
Expression
for IRF2BP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRF2BP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAACTGAAG
About this image
See IRF2BP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRF2BP2
SOURCE GeneReport for Unigene cluster: Hs.350268
SABiosciences Custom PCR Arrays for IRF2BP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF2BP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRF2BP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF2BP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP2 |
Orthologs
for IRF2BP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IRF2BP2 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
IRF2BP21 |
interferon regulatory factor 2 binding protein 2 |
78.6(n)
88.48(a) |
|
428585 XM_426142.3 XP_426142.3 |
lizard
(Anolis carolinensis) |
Reptilia |
IRF2BP26 |
-- |
78(a) |
1 ↔ 1 |
1(219997126-219998898) |
African clawed frog
(Xenopus laevis) |
Amphibia |
irf2bp2-A2 |
interferon regulatory factor 2 binding protein 2 |
79.12(n) |
|
BC044275.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj35c122 |
wufj35c12 |
75.08(n) |
|
335866 BC046025.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG111386 |
-- |
26(a) |
1 → many |
X(12463202-12477226) |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-2606 |
Temporarily Assigned Gene name family member (tag-... |
28(a) |
1 → many |
V(13370091-13380176) |
ENSEMBL Gene Tree for IRF2BP2 (if available)
TreeFam Gene Tree for IRF2BP2 (if available) |
Paralogs
for IRF2BP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IRF2BP2 gene
- IRF2BPL2 IRF2BP12
IRF2BP2 for paralogs About GeneDecksing
|
Genomic Variants
for IRF2BP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRF2BP2 (234740015 - 234745271 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IRF2BP2
1 CNV: 66162 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF2BP2 |
|
Disorders
/ Diseases
for IRF2BP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRF2BP2 for disorders About GeneDecksing
1  disease for IRF2BP2: About MalaCardsbreast cancer
Export disorders for IRF2BP2 gene to outside databases
|
Publications
for IRF2BP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRF2BP2 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with IRF2BP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel co-repressor molecules for interferon regulatory factor-2. (PubMed id 12799427)1, 2, 3 Childs K.S. and Goodbourn S. (2003)
- Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. (PubMed id 21576369)1, 2 Carneiro F.R....Viola J.P. (2011)
- Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. (PubMed id 21887377)1, 2 Teng A.C.... Stewart A.F. (2011)
- IRF2BP2 is a skeletal and cardiac muscle-enriched isc hemia-inducible activator of VEGFA expression. (PubMed id 20702774)1, 2 Teng A.C....Stewart A.F. (2010)
- Genome-wide association of implantable cardioverter-de fibrillator activation with life-threatening arrhythmias. (PubMed id 22247754)1 Murray S.S....Topol E.J. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for IRF2BP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IRF2BP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IRF2BP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IRF2BP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IRF2BP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IRF2BP2 gene:
Search GeneIP for patents involving IRF2BP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IRF2BP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRF2BP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF2BP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2BP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF2BP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF2BP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP2 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP2 |
|  |  |  | | | | ThermoFisher Antibodies for IRF2BP2 |
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