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Aliases for IRF2BP2 Gene

Aliases for IRF2BP2 Gene

  • Interferon Regulatory Factor 2 Binding Protein 2 2 3
  • IRF-2-Binding Protein 2 4
  • IRF-2BP2 4

External Ids for IRF2BP2 Gene

Summaries for IRF2BP2 Gene

Entrez Gene Summary for IRF2BP2 Gene

  • This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF2BP2 Gene

IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Diseases associated with IRF2BP2 include mesenchymal chondrosarcoma. An important paralog of this gene is IRF2BPL.

UniProtKB/Swiss-Prot for IRF2BP2 Gene

  • Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF2BP2 Gene

Genomics for IRF2BP2 Gene

Genomic Location for IRF2BP2 Gene

Start:
234,604,269 bp from pter
End:
234,609,525 bp from pter
Size:
5,257 bases
Orientation:
Minus strand

Genomic View for IRF2BP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2BP2 Gene

Regulatory Elements for IRF2BP2 Gene

Proteins for IRF2BP2 Gene

  • Protein details for IRF2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5L9-I2BP2_HUMAN
    Recommended name:
    Interferon regulatory factor 2-binding protein 2
    Protein Accession:
    Q7Z5L9
    Secondary Accessions:
    • B1AM35
    • B1AM36
    • Q6P083
    • Q7Z5L8
    • Q8N351
    • Q8WUH8

    Protein attributes for IRF2BP2 Gene

    Size:
    587 amino acids
    Molecular mass:
    61025 Da
    Quaternary structure:
    • Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.

    Alternative splice isoforms for IRF2BP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF2BP2 Gene

Proteomics data for IRF2BP2 Gene at MOPED

Post-translational modifications for IRF2BP2 Gene

  • Phosphorylation at Ser-360 is required for nuclear targeting.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF2BP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRF2BP2 Gene

Domains for IRF2BP2 Gene

Protein Domains for IRF2BP2 Gene

UniProtKB/Swiss-Prot:

I2BP2_HUMAN
Domain:
  • The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2:
    • Q7Z5L9
Family:
  • Belongs to the IRF2BP family.:
    • Q7Z5L9
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q7Z5L9
genes like me logo Genes that share domains with IRF2BP2: view

No data available for Gene Families for IRF2BP2 Gene

Function for IRF2BP2 Gene

Molecular function for IRF2BP2 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle.

Gene Ontology (GO) - Molecular Function for IRF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IRF2BP2: view
genes like me logo Genes that share phenotypes with IRF2BP2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IRF2BP2 Gene

Localization for IRF2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2BP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF2BP2 Gene COMPARTMENTS Subcellular localization image for IRF2BP2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IRF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IRF2BP2: view

Pathways for IRF2BP2 Gene

SuperPathways for IRF2BP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with IRF2BP2: view

No data available for Pathways by source for IRF2BP2 Gene

Transcripts for IRF2BP2 Gene

Unigene Clusters for IRF2BP2 Gene

Interferon regulatory factor 2 binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2BP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: - -
SP2: -
SP3:

Relevant External Links for IRF2BP2 Gene

GeneLoc Exon Structure for
IRF2BP2
ECgene alternative splicing isoforms for
IRF2BP2

Expression for IRF2BP2 Gene

mRNA expression in normal human tissues for IRF2BP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRF2BP2 Gene

SOURCE GeneReport for Unigene cluster for IRF2BP2 Gene Hs.350268

genes like me logo Genes that share expressions with IRF2BP2: view

Orthologs for IRF2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRF2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF2BP2 36
  • 99.47 (n)
  • 99.65 (a)
IRF2BP2 37
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF2BP2 36
  • 92.08 (n)
  • 94.65 (a)
IRF2BP2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF2BP2 36
  • 92.34 (n)
  • 91.62 (a)
IRF2BP2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf2bp2 36
  • 86.41 (n)
  • 89.1 (a)
Irf2bp2 16
Irf2bp2 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF2BP2 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf2bp2 36
  • 85.24 (n)
  • 87.52 (a)
chicken
(Gallus gallus)
Aves IRF2BP2 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF2BP2 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia irf2bp2-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia irf2bp2 36
  • 71.14 (n)
  • 72.96 (a)
LOC394851 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8448 36
zebrafish
(Danio rerio)
Actinopterygii irf2bp2a 36
  • 66.46 (n)
  • 68.57 (a)
irf2bp2b 37
  • 58 (a)
OneToOne
wufj35c12 36
fruit fly
(Drosophila melanogaster)
Insecta CG11138 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-260 37
  • 29 (a)
OneToMany
Species with no ortholog for IRF2BP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IRF2BP2 Gene

ENSEMBL:
Gene Tree for IRF2BP2 (if available)
TreeFam:
Gene Tree for IRF2BP2 (if available)

Paralogs for IRF2BP2 Gene

Paralogs for IRF2BP2 Gene

genes like me logo Genes that share paralogs with IRF2BP2: view

Variants for IRF2BP2 Gene

Sequence variations from dbSNP and Humsavar for IRF2BP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4636 -- 234,608,667(-) ACCGC(G/T)GCCGG reference, synonymous-codon
rs8722 -- 234,608,504(+) AGTCA(A/G)GGCCG reference, synonymous-codon
rs8823 -- 234,604,395(-) AGATA(C/T)CAACA utr-variant-3-prime
rs11502 - 234,608,734(-) TGAGG(C/T)GGCAG reference, missense
rs14739 -- 234,607,746(+) AGCCC(C/T)TCTGT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for IRF2BP2 Gene

Variant ID Type Subtype PubMed ID
nsv832914 CNV Loss 17160897
nsv468395 CNV Loss 19166990
nsv827387 CNV Gain 20364138
nsv4921 CNV Insertion 18451855
nsv873316 CNV Loss 21882294
esv25047 CNV Loss 19812545

Relevant External Links for IRF2BP2 Gene

HapMap Linkage Disequilibrium report
IRF2BP2

Disorders for IRF2BP2 Gene

Relevant External Links for IRF2BP2

Genetic Association Database (GAD)
IRF2BP2
genes like me logo Genes that share disorders with IRF2BP2: view

No data available for UniProtKB/Swiss-Prot for IRF2BP2 Gene

Publications for IRF2BP2 Gene

  1. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PMID: 12799427) Childs K.S. … Goodbourn S. (Nucleic Acids Res. 2003) 2 3 4
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 49
  3. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. (PMID: 20702774) Teng A.C. … Stewart A.F. (FASEB J. 2010) 3 4
  4. Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity. (PMID: 21576369) Carneiro F.R. … Viola J.P. (Mol. Cell. Biol. 2011) 3 4
  5. Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. (PMID: 21887377) Teng A.C. … Stewart A.F. (PLoS ONE 2011) 3 4

Products for IRF2BP2 Gene

Sources for IRF2BP2 Gene

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