Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IRF2BP1 Gene

protein-coding   GIFtS: 51
GCID: GC19M046386

Interferon Regulatory Factor 2 Binding Protein 1

  See IRF2BP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interferon Regulatory Factor 2 Binding Protein 11 2
Probable E3 Ubiquitin-Protein Ligase IRF2BP12 3
IRF-2-Binding Protein 12 3
Interferon Regulatory Factor 2-Binding Protein 12
EC 6.3.2.-3
IRF-2BP13

External Ids:    HGNC: 217281   Entrez Gene: 261452   Ensembl: ENSG000001706047   OMIM: 6153315   UniProtKB: Q8IU813   

Export aliases for IRF2BP1 gene to outside databases

Previous GC identifers: GC19M051062 GC19M051078 GC19M042820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IRF2BP1 Gene:
IRF2BP1 (interferon regulatory factor 2 binding protein 1) is a protein-coding gene. Diseases associated with IRF2BP1 include brain cancer. GO annotations related to this gene include ligase activity. An important paralog of this gene is IRF2BPL.

UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81
Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by
histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses
ATF2-dependent transcriptional activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRF2BP1 gene promoter:
         SRF   Bach1   GATA-3   SRF (504 AA)   Pax-6   AP-2gamma   c-Ets-1   AREB6   HEN1   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRF2BP1 promoter sequence
   Search Chromatin IP Primers for IRF2BP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF2BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

IRF2BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF2BP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046386:  view genomic region     (about GC identifiers)

Start:
46,386,866 bp from pter      End:
46,389,376 bp from pter
Size:
2,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81 (See protein sequence)
Recommended Name: Interferon regulatory factor 2-binding protein 1  
Size: 584 amino acids; 61688 Da
Subunit: Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2
Secondary accessions: Q53EL7 Q6DC95 Q9BRZ9 Q9Y4P4

Explore the universe of human proteins at neXtProt for IRF2BP1: NX_Q8IU81

Explore proteomics data for IRF2BP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys314, Lys438
  • Modification sites at PhosphoSitePlus

  • See IRF2BP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056464.1  
    ENSEMBL proteins: 
     ENSP00000307265  

    IRF2BP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IRF2BP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IRF2BP1
    GenScript Custom Purified and Recombinant Proteins Services for IRF2BP1
    Novus Biologicals IRF2BP1 Protein
    Novus Biologicals IRF2BP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRF2BP1

     
    Search eBioscience for Proteins for IRF2BP1 

     
    antibodies-online proteins for IRF2BP1 (3 products) 

     
    antibodies-online peptides for IRF2BP1

    IRF2BP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IRF2BP1
    OriGene Antibodies for IRF2BP1
    OriGene Custom Antibody Services for IRF2BP1
    Novus Biologicals IRF2BP1 Antibodies
    Abcam antibodies for IRF2BP1
    Cloud-Clone Corp. Antibodies for IRF2BP1
    Search ThermoFisher Antibodies for IRF2BP1
    antibodies-online antibodies for IRF2BP1 (19 products) 

    IRF2BP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IRF2BP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRF2BP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRF2BP1
    Cloud-Clone Corp. CLIAs for IRF2BP1
    Search eBioscience for ELISAs for IRF2BP1 
    antibodies-online kits for IRF2BP1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR022750 Interferon_reg_fac2-bd1_2_Znf
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry Q8IU81

    ProtoNet protein and cluster: Q8IU81

    UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81
    Similarity: Belongs to the IRF2BP family
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with IRF2BP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I2BP1_HUMAN, Q8IU81
    Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by
    histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses
    ATF2-dependent transcriptional activation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18671972
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with IRF2BP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IRF2BP1:
     Increased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IRF2BP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRF2BP1:
    hsa-mir-744-5p (MIRT037736), hsa-mir-142-3p (MIRT021548)

    Block miRNA regulation of human, mouse, rat IRF2BP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRF2BP1 (see all 19):
    hsa-miR-142-5p hsa-miR-4311 hsa-miR-15a hsa-miR-513c hsa-miR-486-3p hsa-miR-340 hsa-miR-583 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidIRF2BP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRF2BP1
    Predesigned siRNA for gene silencing in human, mouse, rat IRF2BP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRF2BP1

    Clone
    Products:
         
    OriGene clones in human, mouse for IRF2BP1 (see all 7)
    OriGene ORF clones in mouse, rat for IRF2BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRF2BP1 (NM_015649)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF2BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2BP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IRF2BP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IRF2BP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    I2BP1_HUMAN, Q8IU81: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    lysosome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with IRF2BP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including IRF2BP1: 
              Interferons & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRF2BP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for IRF2BP1 (Q8IU811, 2, 3 ENSP000003072654) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JDP2Q8WYK21, 2, 3, ENSP000002675694EBI-6115514,EBI-1248415 MINT-6699684 MINT-6699839 MINT-6699850 MINT-6699624 I2D: score=3 STRING: ENSP00000267569
    SMAD1Q157972, 3MINT-62018 I2D: score=2 
    ATF2P153362, 3, ENSP000002641104MINT-6699865 I2D: score=2 STRING: ENSP00000264110
    TGIF1Q155833, ENSP000003279594I2D: score=1 STRING: ENSP00000327959
    IRF2P143163, ENSP000003772184I2D: score=4 STRING: ENSP00000377218
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with IRF2BP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRF2BP1 (I2BP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IRF2BP1 gene: 
    NM_015649.1  

    Unigene Cluster for IRF2BP1:

    Interferon regulatory factor 2 binding protein 1
    Hs.515477  [show with all ESTs]
    Unigene Representative Sequence: BC038222
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302165(uc002pds.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRF2BP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRF2BP1 (see all 19):
    hsa-miR-142-5p hsa-miR-4311 hsa-miR-15a hsa-miR-513c hsa-miR-486-3p hsa-miR-340 hsa-miR-583 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidIRF2BP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IRF2BP1
    Predesigned siRNA for gene silencing in human, mouse, rat IRF2BP1
    Clone
    Products:
         
    OriGene clones in human, mouse for IRF2BP1 (see all 7)
    OriGene ORF clones in mouse, rat for IRF2BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRF2BP1 (NM_015649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF2BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2BP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IRF2BP1
    OriGene qSTAR qPCR primer pairs in human, mouse for IRF2BP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRF2BP1
      QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP1
      QuantiFast Probe-based Assays in human, mouse, rat IRF2BP1

    Additional mRNA sequence: 

    AK092407.1 AK223622.1 AK315060.1 AL080159.1 AY278022.1 BC005834.2 BC038222.1 BC039002.1 
    BC078181.1 

    3 DOTS entries:

    DT.97767677  DT.100833121  DT.95145676 

    Selected AceView cDNA sequences (see all 72):

    AY278022 BC005834 AW263406 BP338479 AA365210 BC039002 BC078181 BM021556 
    CD672459 CR623029 BM695100 NM_015649 BC038222 BQ217593 BM917245 H62983 
    BU171735 BQ925495 BM854133 BM451598 BE904998 BX092873 BX353731 BI837274 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IRF2BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGCGAGA
    IRF2BP1 Expression
    About this image

    IRF2BP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRF2BP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515477
        Pathway & Disease-focused RT2 Profiler PCR Array including IRF2BP1: 
              Interferons & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IRF2BP1
    OriGene qSTAR qPCR primer pairs in human, mouse for IRF2BP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRF2BP1
    QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP1
    QuantiFast Probe-based Assays in human, mouse, rat IRF2BP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for IRF2BP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf2bp11 , 5 interferon regulatory factor 2 binding protein 11, 5 87.44(n)1
    96.4(a)1
      7 (9.46 cM)5
    2723591  NM_178757.31  NP_848872.21 
     190040655 
    lizard
    (Anolis carolinensis)
    Reptilia IRF2BP16
    interferon regulatory factor 2 binding protein 1
    57(a)
    1 ↔ 1
    GL344028.1(56468-58309)
    zebrafish
    (Danio rerio)
    Actinopterygii irf2bp11 interferon regulatory factor 2 binding protein 1 63.02(n)
    59(a)
      556852  NM_001044354.2  NP_001037819.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111386
    --
    26(a)
    1 → many
    X(12463202-12477226)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2606
    Protein TAG-260, isoform a
    26(a)
    1 → many
    V(13370104-13380189) WBGene00010867


    ENSEMBL Gene Tree for IRF2BP1 (if available)
    TreeFam Gene Tree for IRF2BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IRF2BP1 gene
    IRF2BPL2  IRF2BP22  
    1 SIMAP similar gene for IRF2BP1 using alignment to 1 protein entry:     I2BP1_HUMAN:
    IRF2BPL

    Find genes that share paralogs with IRF2BP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IRF2BP1 (see all 95)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137396401,2
    C--46386422(+) TTTACC/ACCGTG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs562396871,2
    C--46386424(+) TACCCC/GGTGGA 1 -- int14Minor allele frequency- G:0.18WA NA EA 244
    rs745311611,2
    C,F--46386613(+) AGAAGG/CGTAAT 1 -- int13Minor allele frequency- C:0.15WA NA EA 358
    rs1127768961,2
    C,F--46386674(+) AGCCTC/TAGTAC 1 -- int12Minor allele frequency- T:0.04NA WA 120
    rs765742691,2
    C--46386749(+) CCGGCA/GGGACC 1 -- int10--------
    rs1414067511,2
    C--46386912(+) GGAGC-/GGGGGG 1 -- ut310--------
    rs115503481,2
    C,F--46387344(-) GCCTTC/TATGCA 2 F syn1 ese311Minor allele frequency- T:0.18MN NA NS WA EU 5542
    rs37459271,2
    C,F--46387359(-) TCCTCC/TGTGCC 2 S syn11Minor allele frequency- T:0.06EA 1500
    rs1999478341,2
    --46387420(+) GGCCCC/TGCGCC 2 Q R mis10--------
    rs1997082901,2
    C--46387435(+) TGAACA/TCCCGG 2 E V mis10--------

    HapMap Linkage Disequilibrium report for IRF2BP1 (46386866 - 46389376 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IRF2BP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3958n71CNV Loss21882294
    nsv912172CNV Loss21882294
    nsv510770CNV Loss20534489
    dgv3956n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IRF2BP1
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF2BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615331    OMIM disorders: --

    1 disease for IRF2BP1:    
    About MalaCards
    brain cancer


    Find genes that share disorders with IRF2BP1           About GenesLikeMe


    Export disorders for IRF2BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IRF2BP1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with IRF2BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PubMed id 12799427)1, 2, 3 Childs K.S. and Goodbourn S. (Nucleic Acids Res. 2003)
    2. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PubMed id 18671972)1, 2, 9 Kimura M. (FEBS Lett. 2008)
    3. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26145 HGNC: 21728 AceView: IRF2BP1 Ensembl:ENSG00000170604 euGenes: HUgn26145
    ECgene: IRF2BP1 H-InvDB: IRF2BP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IRF2BP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IRF2BP1 gene:
    Search GeneIP for patents involving IRF2BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for IRF2BP1 (IRF2BP1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IRF2BP1   OriGene RNAi products in human, mouse, rat for IRF2BP1  
     OriGene qPCR primer pairs and template standards for IRF2BP1   OriGene Protein Over-expression Lysate for IRF2BP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IRF2BP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for IRF2BP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IRF2BP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IRF2BP1   OriGene Custom Protein Services for IRF2BP1  

     
     
     Block miRNA regulation of human, mouse, rat IRF2BP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IRF2BP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF2BP1 Predesigned siRNA for gene silencing in human, mouse, rat IRF2BP1
     QuantiFast Probe-based Assays in human, mouse, rat IRF2BP1 QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP1
     PCR Arrays including human, mouse, rat IRF2BP1 Search Chromatin IP Primers for IRF2BP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRF2BP1  GeneGlobe Interaction Network for IRF2BP1
     Regulatory tfbs in IRF2BP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IRF2BP1 GenScript cDNA clones with any tag delivered in your preferred vector for IRF2BP1
     GenScript Custom Assay Services for IRF2BP1 GenScript Custom overexpressing Cell Line Services for IRF2BP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IRF2BP1 (I2BP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IRF2BP1 antibodies
     IRF2BP1 proteins
     IRF2BP1 lysates
     Antibodies for IRF2BP1
     See all of Abcam's Antibodies, Kits and Proteins for IRF2BP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IRF2BP1
     Antibodies for IRF2BP1
     ELISAs for IRF2BP1
     CLIAs for IRF2BP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for IRF2BP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP1
     SwitchGear 3'UTR luciferase reporter plasmids for IRF2BP1
     SwitchGear Promoter luciferase reporter plasmids for IRF2BP1
     Search ThermoFisher Antibodies for IRF2BP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2BP1
     Browse compounds at ApexBio
     Search Addgene for plasmids for IRF2BP1
      Search eBioscience for proteins for IRF2BP1
      Search eBioscience for elisas for IRF2BP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IRF2BP1
     antibodies-online antibodies for IRF2BP1 (19 products)
     antibodies-online kits for IRF2BP1 (4 products)
     antibodies-online peptides for IRF2BP1
     antibodies-online proteins for IRF2BP1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IRF2BP1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4