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Aliases for IRF2BP1 Gene

Aliases for IRF2BP1 Gene

  • Interferon Regulatory Factor 2 Binding Protein 1 2 3 5
  • Probable RING-Type E3 Ubiquitin Transferase IRF2BP1 4
  • Probable E3 Ubiquitin-Protein Ligase IRF2BP1 4
  • IRF-2-Binding Protein 1 4
  • EC 2.3.2.27 4
  • IRF-2BP1 4

External Ids for IRF2BP1 Gene

Previous GeneCards Identifiers for IRF2BP1 Gene

  • GC19M051062
  • GC19M051078
  • GC19M046386
  • GC19M042820

Summaries for IRF2BP1 Gene

GeneCards Summary for IRF2BP1 Gene

IRF2BP1 (Interferon Regulatory Factor 2 Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is IRF2BPL.

UniProtKB/Swiss-Prot for IRF2BP1 Gene

  • Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF2BP1 Gene

Genomics for IRF2BP1 Gene

Regulatory Elements for IRF2BP1 Gene

Enhancers for IRF2BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G045401 1.7 FANTOM5 ENCODE dbSUPER 30.8 +481.6 481598 6.2 CREB3L1 AGO1 FEZF1 YY1 ZNF143 SP3 TBX21 MEF2D GLIS1 RCOR2 ZNF180 IRF2BP1 CD3EAP CCDC61 ERCC1 ENSG00000268810 ENSG00000267114 ENSG00000269148 FBXO46 EML2
GH19G045453 2 FANTOM5 Ensembl ENCODE dbSUPER 23.7 +431.0 430976 4.2 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 FOS SP3 ZNF180 CCDC61 IRF2BP1 ENSG00000267114 ENSG00000259605 FOSB FBXO46 ENSG00000269148 QPCTL ENSG00000266958
GH19G046600 1.4 ENCODE dbSUPER 30.8 -716.2 -716225 4.6 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 ZC3H4 IRF2BP1 ENSG00000268810 CCDC61 PPP5D1 ENSG00000269148 FBXO46 DM1-AS CCDC9 GNG8
GH19G046263 1 ENCODE 33.6 -376.9 -376929 0.2 FEZF1 ELK1 FOS SP3 YY2 JUNB TSHZ1 TBX21 ZNF585B NBN ZC3H4 IRF2BP1 CCDC61 PPP5D1 NOVA2 HIF3A IGFL4 MIR769 PGLYRP1 PNMA8B
GH19G046638 1.4 ENCODE dbSUPER 22.5 -753.2 -753179 2.4 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 BICRA ZC3H4 CCDC61 IRF2BP1 ENSG00000268810 ENSG00000269148 FBXO46 CCDC9 ENSG00000268746 SLC1A5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRF2BP1 on UCSC Golden Path with GeneCards custom track

Promoters for IRF2BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110283 -130 1801 HDGF CREB3L1 AGO1 WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 PAF1

Genomic Location for IRF2BP1 Gene

Chromosome:
19
Start:
45,883,607 bp from pter
End:
45,886,170 bp from pter
Size:
2,564 bases
Orientation:
Minus strand

Genomic View for IRF2BP1 Gene

Genes around IRF2BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRF2BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRF2BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2BP1 Gene

Proteins for IRF2BP1 Gene

  • Protein details for IRF2BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU81-I2BP1_HUMAN
    Recommended name:
    Interferon regulatory factor 2-binding protein 1
    Protein Accession:
    Q8IU81
    Secondary Accessions:
    • Q53EL7
    • Q6DC95
    • Q9BRZ9
    • Q9Y4P4

    Protein attributes for IRF2BP1 Gene

    Size:
    584 amino acids
    Molecular mass:
    61688 Da
    Quaternary structure:
    • Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2.

neXtProt entry for IRF2BP1 Gene

Post-translational modifications for IRF2BP1 Gene

  • Ubiquitination at posLast=314314
  • Modification sites at PhosphoSitePlus

Other Protein References for IRF2BP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRF2BP1 Gene

Domains & Families for IRF2BP1 Gene

Protein Domains for IRF2BP1 Gene

Suggested Antigen Peptide Sequences for IRF2BP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IU81

UniProtKB/Swiss-Prot:

I2BP1_HUMAN :
  • Belongs to the IRF2BP family.
Family:
  • Belongs to the IRF2BP family.
genes like me logo Genes that share domains with IRF2BP1: view

No data available for Gene Families for IRF2BP1 Gene

Function for IRF2BP1 Gene

Molecular function for IRF2BP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

Enzyme Numbers (IUBMB) for IRF2BP1 Gene

Gene Ontology (GO) - Molecular Function for IRF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18671972
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IRF2BP1: view
genes like me logo Genes that share phenotypes with IRF2BP1: view

Animal Model Products

CRISPR Products

miRNA for IRF2BP1 Gene

miRTarBase miRNAs that target IRF2BP1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRF2BP1 Gene

Localization for IRF2BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2BP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRF2BP1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for IRF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with IRF2BP1: view

Pathways & Interactions for IRF2BP1 Gene

SuperPathways for IRF2BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRF2BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with IRF2BP1: view

No data available for Pathways by source and SIGNOR curated interactions for IRF2BP1 Gene

Drugs & Compounds for IRF2BP1 Gene

No Compound Related Data Available

Transcripts for IRF2BP1 Gene

mRNA/cDNA for IRF2BP1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRF2BP1 Gene

Interferon regulatory factor 2 binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2BP1 Gene

No ASD Table

Relevant External Links for IRF2BP1 Gene

GeneLoc Exon Structure for
IRF2BP1
ECgene alternative splicing isoforms for
IRF2BP1

Expression for IRF2BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRF2BP1 Gene

Protein differential expression in normal tissues from HIPED for IRF2BP1 Gene

This gene is overexpressed in Fetal testis (7.9), Peripheral blood mononuclear cells (7.4), Liver, secretome (7.0), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IRF2BP1 Gene



Protein tissue co-expression partners for IRF2BP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRF2BP1 Gene:

IRF2BP1

SOURCE GeneReport for Unigene cluster for IRF2BP1 Gene:

Hs.515477

Evidence on tissue expression from TISSUES for IRF2BP1 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Liver(4.1)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with IRF2BP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRF2BP1 Gene

Orthologs for IRF2BP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRF2BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF2BP1 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia IRF2BP1 35
  • 96 (a)
OneToOne
LOC523963 34
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia IRF2BP1 34 35
  • 91.5 (n)
rat
(Rattus norvegicus)
Mammalia Irf2bp1 34
  • 87.79 (n)
mouse
(Mus musculus)
Mammalia Irf2bp1 34 16 35
  • 87.44 (n)
oppossum
(Monodelphis domestica)
Mammalia IRF2BP1 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF2BP1 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii irf2bp1 34 35
  • 63.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11138 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-260 35
  • 26 (a)
OneToMany
Species where no ortholog for IRF2BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IRF2BP1 Gene

ENSEMBL:
Gene Tree for IRF2BP1 (if available)
TreeFam:
Gene Tree for IRF2BP1 (if available)

Paralogs for IRF2BP1 Gene

Paralogs for IRF2BP1 Gene

(1) SIMAP similar genes for IRF2BP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRF2BP1: view

Variants for IRF2BP1 Gene

Sequence variations from dbSNP and Humsavar for IRF2BP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000950546 -- 45,885,757(+) CGGGA(A/C)GCCTG reference, synonymous-codon
rs1001068744 -- 45,883,719(+) GGAGG(C/T)CCCTT utr-variant-3-prime
rs1001378441 -- 45,887,519(+) CCTGG(A/G)GATAA upstream-variant-2KB
rs1001849374 -- 45,887,827(+) ATTGG(C/T)CTCTG upstream-variant-2KB
rs1001952552 -- 45,883,310(+) TGAGT(A/C)CTCCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IRF2BP1 Gene

Variant ID Type Subtype PubMed ID
nsv510770 CNV deletion 20534489

Variation tolerance for IRF2BP1 Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRF2BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRF2BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF2BP1 Gene

Disorders for IRF2BP1 Gene

Relevant External Links for IRF2BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRF2BP1

No disorders were found for IRF2BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRF2BP1 Gene

Publications for IRF2BP1 Gene

  1. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PMID: 18671972) Kimura M. (FEBS Lett. 2008) 3 4 22 64
  2. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PMID: 12799427) Childs K.S. … Goodbourn S. (Nucleic Acids Res. 2003) 2 3 4 64
  3. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. (PMID: 27637333) Gabriel C.H. … Baumgrass R. (J. Biol. Chem. 2016) 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for IRF2BP1 Gene

Sources for IRF2BP1 Gene

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