IRF2BP1 Gene
protein-coding GIFtS: 47
GCID: GC19M046386
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interferon regulatory factor 2 binding protein 1
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Aliases
for IRF2BP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon Regulatory Factor 2 Binding Protein 11 2 | | DKFZP434M1541 | | IRF-2BP11 3 | | Interferon Regulatory Factor 2-Binding Protein 12 | | Probable E3 Ubiquitin-Protein Ligase IRF2BP12 3 | | EC 6.3.2.-3 | | IRF-2-Binding Protein 12 3 | | |
Export aliases for IRF2BP1 gene to outside databasesPrevious GC identifers: GC19M051062 GC19M051078 GC19M042820 |
Summaries
for IRF2BP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histonedeacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. RepressesATF2-dependent transcriptional activation
|
Genomic Views
for IRF2BP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRF2BP1 gene promoter:
SRF Bach1 GATA-3 SRF (504 AA) Pax-6 AP-2gamma c-Ets-1 AREB6 HEN1 Ik-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRF2BP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2BP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.32IRF2BP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M046386: view genomic region
(about GC identifiers)
Start:
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46,386,866 bp from pter |
End:
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46,389,376 bp from pter |
Size:
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2,511 bases |
Orientation:
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minus strand |
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Proteins
for IRF2BP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81 (See
protein sequence)Recommended Name: Interferon regulatory factor 2-binding protein 1 Size: 584 amino acids; 61688 Da
Subunit: Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2
Subcellular location: Nucleus
Secondary accessions: Q53EL7 Q6DC95 Q9BRZ9 Q9Y4P4Explore the universe of human proteins at neXtProt for IRF2BP1: NX_Q8IU81
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IU81
IRF2BP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056464.1
ENSEMBL proteins: ENSP00000307265
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
IRF2BP1 for ontologies About GeneDecksing
IRF2BP1 Antibody Products:
Assay Products for IRF2BP1: |
Protein
Domains /
Families
for IRF2BP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IRF2BP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IU81ProtoNet protein and cluster: Q8IU81 UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81Similarity: Belongs to the IRF2BP familySimilarity: Contains 1 RING-type zinc finger |
Function
for IRF2BP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: I2BP1_HUMAN, Q8IU81Function: Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histonedeacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. RepressesATF2-dependent transcriptional activationEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016874 | ligase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
IRF2BP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IRF2BP1:
|
Pathways & Interactions
for IRF2BP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF2BP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/17 Interacting proteins for IRF2BP1 (Q8IU812, 3 ENSP000003072654) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
IRF2BP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for IRF2BP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IRF2BP1
Search CenterWatch for drugs/clinical trials and news about IRF2BP1 / I2BP1
|
Transcripts
for IRF2BP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRF2BP1 gene: NM_015649.1 Unigene Cluster for IRF2BP1: Interferon regulatory factor 2 binding protein 1 Hs.515477 [show with all ESTs]Unigene Representative Sequence: BC0382221 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000302165(uc002pds.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IRF2BP1 (NM_015649) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF2BP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2BP1 |
Additional cDNA sequence: AK092407.1 AK223622.1 AK315060.1 AL080159.1 AY278022.1 BC005834.2 BC038222.1 BC039002.1 BC078181.1 3 DOTS entries: DT.97767677 DT.100833121 DT.95145676 24/72 AceView cDNA sequences (see all 72): BM695100 BC005834 BC078181 BM021556 AA365210 BQ217593 BC039002 AW263406 CR623029 BP338479 BC038222 AY278022 BM917245 CD672459 NM_015649 AL552551 BG471217 BQ925495 BE904998 BX462011 BX372367 AL080159 BM451598 BE790531
GeneLoc Exon Structure
|
Expression
for IRF2BP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRF2BP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGGCGAGA
About this image
See IRF2BP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRF2BP1
SOURCE GeneReport for Unigene cluster: Hs.515477
SABiosciences Expression via Pathway-Focused PCR Array including IRF2BP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF2BP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRF2BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF2BP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP1 |
Orthologs
for IRF2BP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IRF2BP1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for IRF2BP1 (if available)
TreeFam Gene Tree for IRF2BP1 (if available) |
Paralogs
for IRF2BP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IRF2BP1 gene
- IRF2BPL2 IRF2BP22
1 SIMAP similar gene for IRF2BP1 using alignment to 1 protein entry: I2BP1_HUMAN:IRF2BPL
IRF2BP1 for paralogs About GeneDecksing
|
Genomic Variants
for IRF2BP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRF2BP1 (46386866 - 46389376 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IRF2BP1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for IRF2BP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRF2BP1 for disorders About GeneDecksing
2  diseases for IRF2BP1: About MalaCardssystemic lupus erythematosus lupus erythematosus
Export disorders for IRF2BP1 gene to outside databases
|
Publications
for IRF2BP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRF2BP1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with IRF2BP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel co-repressor molecules for interferon regulatory factor-2. (PubMed id 12799427)1, 2, 3 Childs K.S. and Goodbourn S. (2003)
- IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PubMed id 18671972)1, 2, 9 Kimura M. (2008)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
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External Searches for IRF2BP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IRF2BP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IRF2BP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IRF2BP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IRF2BP1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IRF2BP1 gene:
Search GeneIP for patents involving IRF2BP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IRF2BP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IRF2BP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF2BP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF2BP1 | | | OriGene Protein Over-expression Lysate for IRF2BP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IRF2BP1 | | OriGene 3'-UTR Clone for IRF2BP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2BP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRF2BP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF2BP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2BP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF2BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF2BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF2BP1 |
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 | | | IRF2BP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2BP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for IRF2BP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2BP1 |
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