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IRF2 Gene

protein-coding   GIFtS: 67
GCID: GC04M185308

Interferon Regulatory Factor 2

  See IRF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Regulatory Factor 21 2
IRF-22 3

External Ids:    HGNC: 61171   Entrez Gene: 36602   Ensembl: ENSG000001683107   OMIM: 1475765   UniProtKB: P143163   

Export aliases for IRF2 gene to outside databases

Previous GC identifers: GC04M186336 GC04M185988 GC04M186004 GC04M185684 GC04M185545 GC04M181063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRF2 Gene:
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF)
family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta,
and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a
transcriptional activator of histone H4. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRF2 Gene:
IRF2 (interferon regulatory factor 2) is a protein-coding gene. Diseases associated with IRF2 include mumps, and eczema herpeticum. GO annotations related to this gene include regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRF8.

UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316
Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
(the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes
including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle
regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell
growth. Antagonizes IRF1 transcriptional activation

Gene Wiki entry for IRF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRF2 gene promoter:
         CREB   STAT1   deltaCREB   ARP-1   STAT3   IRF-7A   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): IRF2 promoter sequence
   Search Chromatin IP Primers for IRF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1-q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q34.1-q35.1

IRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M185308:  view genomic region     (about GC identifiers)

Start:
185,308,867 bp from pter      End:
185,395,734 bp from pter
Size:
86,868 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316 (See protein sequence)
Recommended Name: Interferon regulatory factor 2  
Size: 349 amino acids; 39354 Da
Subunit: Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction
acetylates IRF2 and regulates IRF2-dependent H4 promoter activity
Secondary accessions: D6RCK5 H0Y8S3 Q6IAS7 Q96B99
Alternative splicing: 2 isoforms:  P14316-1   P14316-2   (Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression)

Explore the universe of human proteins at neXtProt for IRF2: NX_P14316

Explore proteomics data for IRF2 at MOPED

Post-translational modifications: 

  • Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter
    activity1
  • The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional
    repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002190.2  
    ENSEMBL proteins: 
     ENSP00000377218   ENSP00000421927   ENSP00000423074   ENSP00000427204   ENSP00000424552  
     ENSP00000422860   ENSP00000425037  
    Reactome Protein details: P14316

    IRF2 Human Recombinant Protein Products:

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    Novus Biologicals IRF2 Proteins
    Novus Biologicals IRF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IRF2
    Cloud-Clone Corp. Proteins for IRF2

     
    Search eBioscience for Proteins for IRF2 

     
    antibodies-online proteins for IRF2 (20 products) 

     
    antibodies-online peptides for IRF2

    IRF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRF2
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    Abcam antibodies for IRF2
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    ThermoFisher Antibodies for IRF2
    antibodies-online antibodies for IRF2 (75 products) 

    IRF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IRF2
    Cloud-Clone Corp. CLIAs for IRF2
    Search eBioscience for ELISAs for IRF2 
    antibodies-online kits for IRF2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR019817 Interferon_reg_fac_CS
     IPR017431 Interferon_reg_fac-1/2
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P14316

    ProtoNet protein and cluster: P14316

    1 Blocks protein domain: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    Find genes that share domains with IRF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRF2_HUMAN, P14316
    Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
    (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes
    including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle
    regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell
    growth. Antagonizes IRF1 transcriptional activation
    Induction: By viruses and IFN

         Genatlas biochemistry entry for IRF2:
    interferon regulatory factor 2,induced in IFN-stimulated cells,protooncogene,repressor of IRF1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding IEA--
    GO:0003677DNA binding IDA9540062
    GO:0003700sequence-specific DNA binding transcription factor activity IMP9540062
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with IRF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IRF2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irf2):
     hematopoietic system  immune system  integument  mortality/aging  normal 

    Find genes that share phenotypes with IRF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Irf2tm1Mak for IRF2

       genOway: Develop your customized and physiologically relevant rodent model for IRF2

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for IRF2 (see all 329):
    ABCB7,  ABCF1,  ACE2,  ACTN2,  ADAM7,  ADAMTS6,  ADH1A,  AGFG1,  AGPAT4,  AHSA1

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GAAASYGAAASY 

    miRNA
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    miRTarBase miRNAs that target IRF2:
    hsa-mir-335-5p (MIRT017202), hsa-mir-30d-5p (MIRT047780)

    Block miRNA regulation of human, mouse, rat IRF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRF2 (see all 45):
    hsa-miR-100* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4314 hsa-miR-372 hsa-miR-4274 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidIRF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRF2
    Predesigned siRNA for gene silencing in human, mouse, rat IRF2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IRF2

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    OriGene ORF clones in mouse, rat for IRF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRF2 (NM_002199)
    Sino Biological Human cDNA Clone for IRF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRF2_HUMAN, P14316: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion ----

    Find genes that share ontologies with IRF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRF2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    2Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    4Hemostasis
    Hemostasis0.43
    5Apoptosis (WikiPathways)
    Apoptosis0.38


    Find genes that share SuperPaths with IRF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for IRF2
        NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for IRF2
        Immune response IFN alpha/beta signaling pathway

    2 BioSystems Pathways for IRF2
        Apoptosis
    Type II interferon signaling (IFNG)


    4 Reactome Pathways for IRF2
        Interferon alpha/beta signaling
    Interferon gamma signaling
    Factors involved in megakaryocyte development and platelet production
    TRAF6 mediated IRF7 activation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF2: 
              HIV Host Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammasomes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRF2 (P143161, 3 ENSP000003772184) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG7O953521, 3, ENSP000003464374EBI-2866589,EBI-987834 I2D: score=1 STRING: ENSP00000346437
    FOXK2Q011671, 3, ENSP000003356774EBI-2866589,EBI-2509991 I2D: score=1 STRING: ENSP00000335677
    PPP3CBP162981, 3, ENSP000003783064EBI-2866589,EBI-1759540 I2D: score=1 STRING: ENSP00000378306
    FOXK1P850371, 3, ENSP000003287204EBI-2866589,EBI-2509974 I2D: score=1 STRING: ENSP00000328720
    IRF8Q025563, ENSP000002686384I2D: score=4 STRING: ENSP00000268638
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7507207
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IMP9540062
    GO:0007596blood coagulation TAS--
    GO:0008283cell proliferation TAS8438157

    Find genes that share ontologies with IRF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRF2

    9 Novoseek inferred chemical compound relationships for IRF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 71.3 3 8704165 (1), 8616023 (1), 12161037 (1)
    chloramphenicol 32.6 1 10739671 (1)
    cycloheximide 31.2 1 9142651 (1)
    phorbol 22.2 1 15496418 (1)
    retinoic acid 9.66 2 8704165 (2)
    oligonucleotide 0 1 15576464 (1)
    nitric oxide 0 1 18511292 (1)
    tyrosine 0 3 9092512 (2), 17200120 (1)
    serine 0 3 9213219 (2), 17200120 (1)



    Find genes that share compounds with IRF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRF2 gene: 
    NM_002199.3  

    Unigene Cluster for IRF2:

    Interferon regulatory factor 2
    Hs.654566  [show with all ESTs]
    Unigene Representative Sequence: BX648934
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393593(uc003iwf.4) ENST00000505067 ENST00000502750 ENST00000507523
    ENST00000512020 ENST00000510814 ENST00000506230 ENST00000509274 ENST00000504340

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    Selected qRT-PCR Assays for microRNAs that regulate IRF2 (see all 45):
    hsa-miR-100* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4314 hsa-miR-372 hsa-miR-4274 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidIRF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IRF2
    Clone
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    GenScript: all cDNA clones in your preferred vector: IRF2 (NM_002199)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRF2
      QuantiTect SYBR Green Assays in human, mouse, rat IRF2
      QuantiFast Probe-based Assays in human, mouse, rat IRF2

    Additional mRNA sequence: 

    AK312953.1 BC015803.2 BT007264.1 BX648934.1 CR457077.1 DQ409328.1 X15949.1 

    14 DOTS entries:

    DT.215977  DT.100026528  DT.100778122  DT.99999379  DT.100753213  DT.87078908  DT.121273334  DT.121273344 
    DT.121273348  DT.121273353  DT.121273358  DT.40117371  DT.95287940  DT.121273326 

    Selected AceView cDNA sequences (see all 197):

    AA502374 BM802791 BM995971 CA444409 AI026022 CD672836 BU742880 BX108874 
    AA416883 AW162519 AI817424 AA361545 AA857728 BM807472 AA587279 CR457077 
    AA426109 AA346665 BT007264 AI872657 AW160651 W90683 AV706954 BI821870 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IRF2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                          -     -     -     -     -           -                       -                                   -                                 
    SP2:                                                                                      -                                                                     
    SP3:                          -     -     -     -     -           -                       -     -     -                       -                                 
    SP4:                          -     -     -     -     -           -                       -     -     -     -     -     -     -                                 
    SP5:                                -     -     -     -           -                       -                                                                     


    ECgene alternative splicing isoforms for IRF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAATCAG
    IRF2 Expression
    About this image


    IRF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
    IRF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654566

    UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316
    Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF2: 
              HIV Host Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammasomes in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IRF2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf21 , 5 interferon regulatory factor 21, 5 88.73(n)1
    92.55(a)1
      8 (26.42 cM)5
    163631  NM_008391.41  NP_032417.31 
     467397455 
    chicken
    (Gallus gallus)
    Aves IRF21 interferon regulatory factor 2 79.38(n)
    84.39(a)
      396115  NM_205196.1  NP_990527.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRF26
    interferon regulatory factor 2
    61(a)
    1 ↔ 1
    5(113366773-113388701)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.326032 Xenopus laevis transcribed sequence with moderate similarity more 78.53(n)    BJ029497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii irf21 interferon regulatory factor 2 76.4(n)
    89.38(a)
      494071  NM_001008614.1  NP_001008614.1 


    ENSEMBL Gene Tree for IRF2 (if available)
    TreeFam Gene Tree for IRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRF2 gene
    IRF82  IRF52  IRF32  IRF42  IRF92  IRF12  IRF72  IRF62  
    Selected SIMAP similar genes for IRF2 using alignment to 8 protein entries:     IRF2_HUMAN (see all proteins) (see all similar genes):
    SLC35E3    BRF2    RAD51    HINFP    RRM2B    TGM4
    PFKFB3    ARL6IP5    BEAN1    CDK10    ATF1    ZNF428
    TUBA1C    ADCK1    RQCD1    SH2B3    C1orf143    KIAA1651

    Find genes that share paralogs with IRF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRF2 (see all 1945)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383178991,2
    --185308440(+) CTCCCA/GACACA 1 -- ds50010--------
    rs1851019441,2
    --185308458(+) ACAGAC/TATTTG 1 -- ds50010--------
    rs68174121,2
    C,F,A,H--185308459(+) CAGACA/GTTTGA 1 -- ds500122Minor allele frequency- G:0.32NS EA NA WA 2760
    rs1438957681,2
    --185308472(+) TAACGG/TATATG 1 -- ds50010--------
    rs1906546631,2
    --185308639(+) CTACAA/GCACAA 1 -- ds50010--------
    rs48616221,2
    C,F,H--185308661(+) GAAGAC/TGGGAA 1 -- ds500117Minor allele frequency- T:0.10NS EA NA WA 2338
    rs1443052461,2
    --185308748(+) AGAACA/CTCCAC 1 -- ds50010--------
    rs614417581,2
    C--185308976(+) AAATT-/AAAAAA 1 -- ut310--------
    rs1819499111,2
    --185309004(+) ATGTAA/GTAACA 1 -- ut310--------
    rs1870374291,2
    --185309104(+) TTGAAA/TAAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IRF2 (185308867 - 185395734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IRF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515626CNV Loss19592680
    esv29408CNV Loss19812545
    nsv528892CNV Loss19592680
    nsv830167CNV Gain17160897

    Human Gene Mutation Database (HGMD): IRF2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRF2
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147576    OMIM disorders: --

    2 diseases for IRF2:    
    About MalaCards
    mumps    eczema herpeticum


    Find genes that share disorders with IRF2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IRF2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hematopoietic malignancies 34.8 1 7687740 (1)
    virus infection 28.7 6 11090630 (2), 10094406 (1), 9251759 (1), 11721886 (1)
    psoriasis 23.3 15 14962090 (4), 15086546 (4), 12474233 (3)
    mumps 20.4 1 8981353 (1)
    pancreatic tumor 15.3 6 10956389 (3), 10557076 (1)
    tumors 12 36 11323500 (3), 16241857 (2), 10956389 (2), 9251759 (2) (see all 16)
    solid tumor 11.1 1 19170204 (1)
    carcinoid 5.34 5 10942060 (5)
    skin diseases 5.07 2 14962090 (1)
    breast carcinoma 2.53 3 14565859 (1), 16241857 (1)

    Genetic Association Database (GAD): IRF2
    Human Genome Epidemiology (HuGE) Navigator: IRF2 (8 documents)

    Export disorders for IRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRF2 gene, integrated from 10 sources (see all 183):
    (articles sorted by number of sources associating them with IRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of the IRF-2 gene as a candidate for PSORS3. (PubMed id 14962090)1, 4, 9 Foerster J....te Meerman G. (J. Invest. Dermatol. 2004)
    2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PubMed id 11025449)1, 2, 9 Staal A.... van Wijnen A.J. (J. Cell. Physiol. 2000)
    3. Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. (PubMed id 11721886)1, 4, 9 Nishio Y....Arinami T. (J. Hum. Genet. 2001)
    4. Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region. (PubMed id 8106512)1, 2, 9 Cha Y. and Deisseroth A.B. (J. Biol. Chem. 1994)
    5. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PubMed id 12799427)1, 2, 9 Childs K.S. and Goodbourn S. (Nucleic Acids Res. 2003)
    6. Regulation of IRF2 transcriptional activity by its sumoylation. (PubMed id 18514056)1, 2, 9 Han K.-J.... Shu H.-B. (Biochem. Biophys. Res. Commun. 2008)
    7. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. (PubMed id 9540062)1, 2, 9 Aziz F.... Stein G.S. (Mol. Biol. Rep. 1998)
    8. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up- regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. (PubMed id 15226432)1, 2, 9 Oshima S....Watanabe M. (Mol. Cell. Biol. 2004)
    9. Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway. (PubMed id 20980339)1, 4 Huang H.H....Yu M.W. (Gut 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3660 HGNC: 6117 AceView: IRF2 Ensembl:ENSG00000168310 euGenes: HUgn3660
    ECgene: IRF2 H-InvDB: IRF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IRF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IRF2 gene:
    Search GeneIP for patents involving IRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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