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Aliases for IRF2 Gene

Aliases for IRF2 Gene

  • Interferon Regulatory Factor 2 2 3
  • IRF-2 3 4

External Ids for IRF2 Gene

Summaries for IRF2 Gene

Entrez Gene Summary for IRF2 Gene

  • IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRF2 Gene

IRF2 (Interferon Regulatory Factor 2) is a Protein Coding gene. Diseases associated with IRF2 include mumps and eczema herpeticum. Among its related pathways are Hemostasis and Interferon Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and regulatory region DNA binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF2 Gene

  • Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Gene Wiki entry for IRF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF2 Gene

Genomics for IRF2 Gene

Genomic Location for IRF2 Gene

Start:
184,387,713 bp from pter
End:
184,474,580 bp from pter
Size:
86,868 bases
Orientation:
Minus strand

Genomic View for IRF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF2 Gene

Regulatory Elements for IRF2 Gene

Proteins for IRF2 Gene

  • Protein details for IRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14316-IRF2_HUMAN
    Recommended name:
    Interferon regulatory factor 2
    Protein Accession:
    P14316
    Secondary Accessions:
    • D6RCK5
    • H0Y8S3
    • Q6IAS7
    • Q96B99

    Protein attributes for IRF2 Gene

    Size:
    349 amino acids
    Molecular mass:
    39354 Da
    Quaternary structure:
    • Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity.

    Alternative splice isoforms for IRF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRF2 Gene

Proteomics data for IRF2 Gene at MOPED

Post-translational modifications for IRF2 Gene

  • Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
  • The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF2 Gene

No data available for DME Specific Peptides for IRF2 Gene

Domains for IRF2 Gene

UniProtKB/Swiss-Prot:

IRF2_HUMAN
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.:
    • P14316
Family:
  • Belongs to the IRF family.:
    • P14316
genes like me logo Genes that share domains with IRF2: view

No data available for Gene Families for IRF2 Gene

Function for IRF2 Gene

Molecular function for IRF2 Gene

GENATLAS Biochemistry: interferon regulatory factor 2,induced in IFN-stimulated cells,protooncogene,repressor of IRF1
UniProtKB/Swiss-Prot Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
UniProtKB/Swiss-Prot Induction: By viruses and IFN

Gene Ontology (GO) - Molecular Function for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 9540062
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 9540062
GO:0003677 DNA binding IDA 9540062
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 9540062
genes like me logo Genes that share ontologies with IRF2: view
genes like me logo Genes that share phenotypes with IRF2: view

Animal Models for IRF2 Gene

MGI Knock Outs for IRF2:

miRNA for IRF2 Gene

miRTarBase miRNAs that target IRF2

Transcription Factor Targeting for IRF2 Gene

Selected GeneGlobe predicted Target genes for IRF2
Targeting motifs for IRF2 Gene
HOMER Transcription Factor Regulatory Elements motif IRF2
  • Consensus sequence: GAAASYGAAASY Submotif: canonical Cell Type: Erythroblas GeoId: GSE36985

No data available for Enzyme Numbers (IUBMB) for IRF2 Gene

Localization for IRF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF2 Gene COMPARTMENTS Subcellular localization image for IRF2 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with IRF2: view

Pathways for IRF2 Gene

genes like me logo Genes that share pathways with IRF2: view

Pathways by source for IRF2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for IRF2 Gene
1 Cell Signaling Technology pathway for IRF2 Gene

Gene Ontology (GO) - Biological Process for IRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 7507207
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IMP 9540062
GO:0007596 blood coagulation TAS --
GO:0008283 cell proliferation TAS 8438157
genes like me logo Genes that share ontologies with IRF2: view

Compounds for IRF2 Gene

(9) Novoseek inferred chemical compound relationships for IRF2 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 71.3 3
chloramphenicol 32.6 1
cycloheximide 31.2 1
phorbol 22.2 1
retinoic acid 9.66 2
genes like me logo Genes that share compounds with IRF2: view

Transcripts for IRF2 Gene

Unigene Clusters for IRF2 Gene

Interferon regulatory factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRF2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - -
SP10: - - -
SP11: - - -

Relevant External Links for IRF2 Gene

GeneLoc Exon Structure for
IRF2
ECgene alternative splicing isoforms for
IRF2

Expression for IRF2 Gene

mRNA expression in normal human tissues for IRF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRF2 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRF2 Gene

SOURCE GeneReport for Unigene cluster for IRF2 Gene Hs.654566

mRNA Expression by UniProt/SwissProt for IRF2 Gene

P14316-IRF2_HUMAN
Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
genes like me logo Genes that share expressions with IRF2: view

Orthologs for IRF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF2 36
  • 99.33 (n)
  • 99.43 (a)
IRF2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF2 36
  • 89.37 (n)
  • 91.67 (a)
IRF2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF2 36
  • 92.26 (n)
  • 95.13 (a)
IRF2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf2 36
  • 88.73 (n)
  • 92.55 (a)
Irf2 16
Irf2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF2 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRF2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf2 36
  • 88.44 (n)
  • 92.26 (a)
chicken
(Gallus gallus)
Aves IRF2 36
  • 79.38 (n)
  • 84.39 (a)
IRF2 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRF2 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32603 36
tropical clawed frog
(Silurana tropicalis)
Amphibia irf2 36
  • 65.79 (n)
  • 69.19 (a)
Str.2206 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.42 36
zebrafish
(Danio rerio)
Actinopterygii irf2 36
  • 76.4 (n)
  • 89.38 (a)
IRF2 (2 of 2) 37
  • 56 (a)
OneToMany
irf2a 37
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 15 (a)
OneToMany
Species with no ortholog for IRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF2 Gene

ENSEMBL:
Gene Tree for IRF2 (if available)
TreeFam:
Gene Tree for IRF2 (if available)

Paralogs for IRF2 Gene

Paralogs for IRF2 Gene

genes like me logo Genes that share paralogs with IRF2: view

Variants for IRF2 Gene

Sequence variations from dbSNP and Humsavar for IRF2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs712033 -- 184,432,973(-) Ctgtt(A/G)gttgc intron-variant
rs712034 -- 184,455,573(-) TATGT(A/G)CAAGC intron-variant
rs724528 -- 184,402,572(-) CTCTC(C/T)GGTGG intron-variant
rs737405 -- 184,459,126(-) CTGCT(C/T)GGGAC intron-variant
rs744038 -- 184,431,259(-) GAACA(A/G)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRF2 Gene

Variant ID Type Subtype PubMed ID
nsv830167 CNV Gain 17160897
nsv515626 CNV Loss 19592680
nsv528892 CNV Loss 19592680
esv29408 CNV Loss 19812545

Relevant External Links for IRF2 Gene

HapMap Linkage Disequilibrium report
IRF2
Human Gene Mutation Database (HGMD)
IRF2

Disorders for IRF2 Gene

(2) MalaCards Diseases for IRF2 Gene

Search for IRF2 Gene in MalaCards »

(15) Novoseek inferred disease relationships for IRF2 Gene

Disease -log(P) Hits PubMed IDs
hematopoietic malignancies 34.8 1
virus infection 28.7 5
psoriasis 23.3 11
mumps 20.4 1
pancreatic tumor 15.3 4

Relevant External Links for IRF2

Genetic Association Database (GAD)
IRF2
Human Genome Epidemiology (HuGE) Navigator
IRF2
genes like me logo Genes that share disorders with IRF2: view

No data available for UniProtKB/Swiss-Prot for IRF2 Gene

Publications for IRF2 Gene

  1. Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region. (PMID: 8106512) Cha Y. … Deisseroth A.B. (J. Biol. Chem. 1994) 3 4 23
  2. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. (PMID: 9540062) Aziz F. … Stein G.S. (Mol. Biol. Rep. 1998) 3 4 23
  3. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PMID: 11025449) Staal A. … van Wijnen A.J. (J. Cell. Physiol. 2000) 3 4 23
  4. Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. (PMID: 11721886) Nishio Y. … Arinami T. (J. Hum. Genet. 2001) 3 23 49
  5. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PMID: 12799427) Childs K.S. … Goodbourn S. (Nucleic Acids Res. 2003) 3 4 23

Products for IRF2 Gene

Sources for IRF2 Gene

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