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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRF2 Gene

protein-coding   GIFtS: 66
GCID: GC04M185308

Interferon Regulatory Factor 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Regulatory Factor 21 2
IRF-22 3

External Ids:    HGNC: 61171   Entrez Gene: 36602   Ensembl: ENSG000001683107   OMIM: 1475765   UniProtKB: P143163   

Export aliases for IRF2 gene to outside databases

Previous GC identifers: GC04M186336 GC04M185988 GC04M186004 GC04M185684 GC04M185545 GC04M181063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRF2 Gene:
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF)
family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta,
and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a
transcriptional activator of histone H4. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRF2 Gene: 
IRF2 (interferon regulatory factor 2) is a protein-coding gene. Diseases associated with IRF2 include mumps, and eczema herpeticum, and among its related super-pathways are Immune response IFN alpha/beta signaling pathway and Interferon Signaling. GO annotations related to this gene include regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRF8.

UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316
Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
(the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes
including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle
regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell
growth. Antagonizes IRF1 transcriptional activation

Gene Wiki entry for IRF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRF2 gene promoter:
         CREB   STAT1   deltaCREB   ARP-1   STAT3   IRF-7A   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): IRF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1-q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q34.1-q35.1

IRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M185308:  view genomic region     (about GC identifiers)

Start:
185,308,867 bp from pter      End:
185,395,734 bp from pter
Size:
86,868 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316 (See protein sequence)
Recommended Name: Interferon regulatory factor 2  
Size: 349 amino acids; 39354 Da
Subunit: Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction
acetylates IRF2 and regulates IRF2-dependent H4 promoter activity
Subcellular location: Nucleus
Secondary accessions: D6RCK5 H0Y8S3 Q6IAS7 Q96B99
Alternative splicing: 2 isoforms:  P14316-1   P14316-2   (Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression)

Explore the universe of human proteins at neXtProt for IRF2: NX_P14316

Explore proteomics data for IRF2 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter
    activity
  • UniProtKB: The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional
    repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14316

  • IRF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRF2 Protein Expression
    REFSEQ proteins: NP_002190.2  
    ENSEMBL proteins: 
     ENSP00000377218   ENSP00000421927   ENSP00000423074   ENSP00000427204   ENSP00000424552  
     ENSP00000422860   ENSP00000425037  
    Reactome Protein details: P14316
    Human Recombinant Protein Products for IRF2: 
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    Enzo Life Sciences proteins for IRF2
    OriGene Purified Protein for IRF2
    OriGene Protein Over-expression Lysate for IRF2
    OriGene MassSpec for IRF2 
    OriGene Custom Protein Services for IRF2
    GenScript Custom Purified and Recombinant Proteins Services for IRF2
    Novus Biologicals IRF2 Proteins
    Novus Biologicals IRF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IRF2
    Cloud-Clone Corp. Proteins for IRF2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion IDA--

    IRF2 for ontologies           About GeneDecksing



    IRF2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRF2
    R&D Systems Antibodies for IRF2
    Cell Signaling Technology (CST) Antibodies for IRF2 
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    Novus Biologicals IRF2 Antibodies
    Abcam antibodies for IRF2
    Cloud-Clone Corp. Antibodies for IRF2 
    ThermoFisher Antibodies for IRF2
    LSBio Antibodies in human, mouse, rat for IRF2 

    Assay Products for IRF2: 
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRF2 
    Cloud-Clone Corp. CLIAs for IRF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR019817 Interferon_reg_fac_CS
     IPR017431 Interferon_reg_fac-1/2
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P14316

    ProtoNet protein and cluster: P14316

    1 Blocks protein domain: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    IRF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRF2_HUMAN, P14316
    Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
    (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes
    including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle
    regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell
    growth. Antagonizes IRF1 transcriptional activation
    Induction: By viruses and IFN

         Genatlas biochemistry entry for IRF2:
    interferon regulatory factor 2,induced in IFN-stimulated cells,protooncogene,repressor of IRF1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding IEA--
    GO:0003677DNA binding IDA9540062
    GO:0003700sequence-specific DNA binding transcription factor activity IMP9540062
    GO:0005515protein binding IPI--
         
    IRF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IRF2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irf2):
     cellular  hematopoietic system  immune system  integument  mortality/aging 
     normal 

    IRF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irf2tm1Mak for IRF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRF2 

    10/336 SABiosciences Target genes for IRF2 (see all 336):
    ABCB7 ABCF1 ACE2 ACTN2 ADAM7 ADAMTS6 ADH1A AGFG1 AGPAT4 AHSA1

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate IRF2 (see all 45):
    hsa-miR-100* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4314 hsa-miR-372 hsa-miR-4274 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidIRF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of IRF2

    Clone
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    GenScript: all cDNA clones in your preferred vector: IRF2 (NM_002199)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2
    Sirion Biotech Customized lentivirus for stable overexpression of IRF2 
                         Customized lentivirus expression plasmids for stable overexpression of IRF2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IRF2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha/beta signaling pathway
    Immune response IFN alpha/beta signaling pathway0.71
    Interferon alpha/beta signaling0.45
    2Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    3Immune System
    Immune System0.56
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Apoptosis Modulation and Signaling
    Apoptosis0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IRF2
        Immune response IFN alpha/beta signaling pathway


    1 Cell Signaling Technology (CST) Pathway for IRF2
        NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for IRF2
        Immune response IFN alpha/beta signaling pathway

    2 BioSystems Pathways for IRF2
        Apoptosis
    Type II interferon signaling (IFNG)

    5/7        Reactome Pathways for IRF2 (see all 7)
        Hemostasis
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Cytokine Signaling in Immune system
    Factors involved in megakaryocyte development and platelet production



    IRF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for IRF2 (P143161, 3 ENSP000003772184) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG7O953521, 3, ENSP000003464374EBI-2866589,EBI-987834 I2D: score=1 STRING: ENSP00000346437
    FOXK2Q011671, 3, ENSP000003356774EBI-2866589,EBI-2509991 I2D: score=1 STRING: ENSP00000335677
    PPP3CBP162981, 3, ENSP000003783064EBI-2866589,EBI-1759540 I2D: score=1 STRING: ENSP00000378306
    FOXK1P850371, 3, ENSP000003287204EBI-2866589,EBI-2509974 I2D: score=1 STRING: ENSP00000328720
    IRF8Q025563, ENSP000002686384I2D: score=4 STRING: ENSP00000268638
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS7507207
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IMP9540062
    GO:0007596blood coagulation TAS--
    GO:0008283cell proliferation TAS8438157

    IRF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRF2

    9 Novoseek inferred chemical compound relationships for IRF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 71.3 3 8704165 (1), 8616023 (1), 12161037 (1)
    chloramphenicol 32.6 1 10739671 (1)
    cycloheximide 31.2 1 9142651 (1)
    phorbol 22.2 1 15496418 (1)
    retinoic acid 9.66 2 8704165 (2)
    oligonucleotide 0 1 15576464 (1)
    nitric oxide 0 1 18511292 (1)
    tyrosine 0 3 9092512 (2), 17200120 (1)
    serine 0 3 9213219 (2), 17200120 (1)

    Search CenterWatch for drugs/clinical trials and news about IRF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRF2 gene: 
    NM_002199.3  

    Unigene Cluster for IRF2:

    Interferon regulatory factor 2
    Hs.654566  [show with all ESTs]
    Unigene Representative Sequence: BX648934
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393593(uc003iwf.4) ENST00000505067 ENST00000502750 ENST00000507523
    ENST00000512020 ENST00000510814 ENST00000506230 ENST00000509274 ENST00000504340

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate IRF2 (see all 45):
    hsa-miR-100* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4314 hsa-miR-372 hsa-miR-4274 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidIRF2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK312953.1 BC015803.2 BT007264.1 BX648934.1 CR457077.1 DQ409328.1 X15949.1 

    14 DOTS entries:

    DT.215977  DT.100026528  DT.100778122  DT.99999379  DT.100753213  DT.87078908  DT.121273334  DT.121273344 
    DT.121273348  DT.121273353  DT.121273358  DT.40117371  DT.95287940  DT.121273326 

    24/197 AceView cDNA sequences (see all 197):

    W90683 AA857728 AA502374 BM995971 AA426109 AW160651 CA444409 AA346665 
    AA361545 AW162519 BM802791 BX108874 AA587279 BM807472 AA416883 AI872657 
    CD672836 BU742880 AI026022 AI817424 CR457077 BT007264 BQ050135 BM718255 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IRF2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:                          -     -     -     -     -           -                       -                                   -                                 
    SP2:                                                                                      -                                                                     
    SP3:                          -     -     -     -     -           -                       -     -     -                       -                                 
    SP4:                          -     -     -     -     -           -                       -     -     -     -     -     -     -                                 
    SP5:                                -     -     -     -           -                       -                                                                     


    ECgene alternative splicing isoforms for IRF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRF2 expression in normal human tissues (normalized intensities)      IRF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAATCAG
    IRF2 Expression
    About this image


    IRF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             TONGUE   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             skeletal muscle ; myocytes   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             monocytes   

    See IRF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRF2

    SOURCE GeneReport for Unigene cluster: Hs.654566

    UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316
    Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria

        SABiosciences Expression via Pathway-Focused PCR Arrays including IRF2: 
              HIV Host Response in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IRF2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf21 , 5 interferon regulatory factor 21, 5 88.73(n)1
    92.55(a)1
      8 (26.42 cM)5
    163631  NM_008391.41  NP_032417.31 
     467397455 
    chicken
    (Gallus gallus)
    Aves IRF21 interferon regulatory factor 2 80.06(n)
    84.68(a)
      396115  NM_205196.1  NP_990527.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRF26
    interferon regulatory factor 2
    24(a)
    1 ↔ 1
    5(113366773-113388701)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.326032 Xenopus laevis transcribed sequence with moderate similarity more 78.53(n)    BJ029497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii irf2a1 interferon regulatory factor 2a 71.93(n)
    77.44(a)
      325410  NM_207054.1  NP_996937.1 


    ENSEMBL Gene Tree for IRF2 (if available)
    TreeFam Gene Tree for IRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRF2 gene
    IRF82  IRF52  IRF32  IRF42  IRF92  IRF12  IRF72  IRF62  
    18/89 SIMAP similar genes for IRF2 using alignment to 9 protein entries:     IRF2_HUMAN (see all proteins) (see all similar genes):
    SLC35E3    BRF2    RAD51    HINFP    RRM2B    TGM4
    PFKFB3    ARL6IP5    BEAN1    CDK10    ATF1    ZNF428
    TUBA1C    ADCK1    RQCD1    SH2B3    C1orf143    KIAA1651

    IRF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1945 SNPs in IRF2 are shown (see all 1945)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383178991,2
    --185308440(+) CTCCCA/GACACA 1 -- ds50010--------
    rs1851019441,2
    --185308458(+) ACAGAC/TATTTG 1 -- ds50010--------
    rs68174121,2
    C,F,A,H--185308459(+) CAGACA/GTTTGA 1 -- ds500122Minor allele frequency- G:0.32NS EA NA WA 2760
    rs1438957681,2
    --185308472(+) TAACGG/TATATG 1 -- ds50010--------
    rs1906546631,2
    --185308639(+) CTACAA/GCACAA 1 -- ds50010--------
    rs48616221,2
    C,F,H--185308661(+) GAAGAC/TGGGAA 1 -- ds500117Minor allele frequency- T:0.10NS EA NA WA 2338
    rs1443052461,2
    --185308748(+) AGAACA/CTCCAC 1 -- ds50010--------
    rs614417581,2
    C--185308976(+) AAATT-/AAAAAA 1 -- ut310--------
    rs1819499111,2
    --185309004(+) ATGTAA/GTAACA 1 -- ut310--------
    rs1870374291,2
    --185309104(+) TTGAAA/TAAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IRF2 (185308867 - 185395734 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IRF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv515626CNV Loss19592680
    esv29408CNV Loss19812545
    nsv528892CNV Loss19592680
    nsv830167CNV Gain17160897


    Human Gene Mutation Database (HGMD): IRF2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147576    OMIM disorders: --

    20/35 diseases for IRF2 (see all 35):    About MalaCards
    mumps    eczema herpeticum    juvenile myelomonocytic leukemia    polyploidy
    bullous pemphigoid    skin disease    eczema    atopy
    psoriasis    esophageal cancer    atopic dermatitis    myeloid leukemia
    dermatitis    acute myeloid leukemia    multiple myeloma    astrocytoma
    myeloma    pancreatitis    hepatitis c    multiple sclerosis


    IRF2 for disorders           About GeneDecksing

    10/15 Novoseek inferred disease relationships for IRF2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hematopoietic malignancies 34.8 1 7687740 (1)
    virus infection 28.7 6 11090630 (2), 10094406 (1), 9251759 (1), 11721886 (1)
    psoriasis 23.3 15 14962090 (4), 15086546 (4), 12474233 (3)
    mumps 20.4 1 8981353 (1)
    pancreatic tumor 15.3 6 10956389 (3), 10557076 (1)
    tumors 12 36 11323500 (3), 16241857 (2), 10956389 (2), 9251759 (2) (see all 16)
    solid tumor 11.1 1 19170204 (1)
    carcinoid 5.34 5 10942060 (5)
    skin diseases 5.07 2 14962090 (1)
    breast carcinoma 2.53 3 14565859 (1), 16241857 (1)

    Genetic Association Database (GAD): IRF2
    Human Genome Epidemiology (HuGE) Navigator: IRF2 (8 documents)

    Export disorders for IRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRF2 gene, integrated from 9 sources (see all 182):
    (articles sorted by number of sources associating them with IRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of the IRF-2 gene as a candidate for PSORS3. (PubMed id 14962090)1, 4, 9 Foerster J....te Meerman G. (2004)
    2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PubMed id 11025449)1, 2, 9 Staal A.... van Wijnen A.J. (2000)
    3. Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. (PubMed id 11721886)1, 4, 9 Nishio Y....Arinami T. (2001)
    4. Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region. (PubMed id 8106512)1, 2, 9 Cha Y. and Deisseroth A.B. (1994)
    5. Identification of novel co-repressor molecules for interferon regulatory factor-2. (PubMed id 12799427)1, 2, 9 Childs K.S. and Goodbourn S. (2003)
    6. Regulation of IRF2 transcriptional activity by its sumoylation. (PubMed id 18514056)1, 2, 9 Han K.-J.... Shu H.-B. (2008)
    7. The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. (PubMed id 9540062)1, 2, 9 Aziz F.... Stein G.S. (1998)
    8. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up- regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. (PubMed id 15226432)1, 2, 9 Oshima S....Watanabe M. (2004)
    9. Hepatitis B viraemia: its heritability and associatio n with common genetic variation in the interferon {gamma} signalling pathway. (PubMed id 20980339)1, 4 Huang H.H....Yu M.W. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3660 HGNC: 6117 AceView: IRF2 Ensembl:ENSG00000168310 euGenes: HUgn3660
    ECgene: IRF2 H-InvDB: IRF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IRF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRF2 gene:
    Search GeneIP for patents involving IRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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