IRF2 Gene
protein-coding GIFtS: 66
GCID: GC04M185308
|
|
interferon regulatory factor 2
| |
Aliases
for IRF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon Regulatory Factor 21 2 | | IRF-22 3 |
Export aliases for IRF2 gene to outside databasesPrevious GC identifers: GC04M186336 GC04M185988 GC04M186004 GC04M185684 GC04M185545 GC04M181063 |
Summaries
for IRF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IRF2:
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family.IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumablyother genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activatorof histone H4. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (theinterferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes includingH4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation throughbinding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1transcriptional activation
Gene Wiki entry for IRF2
|
Genomic Views
for IRF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRF2 gene promoter:
CREB STAT1 deltaCREB ARP-1 STAT3 IRF-7A STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q34.1-q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q34.1-q35.1IRF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M185308: view genomic region
(about GC identifiers)
Start:
|
185,308,867 bp from pter |
End:
|
185,395,734 bp from pter |
Size:
|
86,868 bases |
Orientation:
|
minus strand |
|
Proteins
for IRF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316 (See
protein sequence)Recommended Name: Interferon regulatory factor 2 Size: 349 amino acids; 39354 Da
Subunit: Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylatesIRF2 and regulates IRF2-dependent H4 promoter activity
Subcellular location: Nucleus
Secondary accessions: D6RCK5 H0Y8S3 Q6IAS7 Q96B99Alternative splicing: 2 isoforms: P14316-1 P14316-2 (Unable to bind to IRF2BP1 and IRF2BP2 corepressors and cannot mediate repression)Explore the universe of human proteins at neXtProt for IRF2: NX_P14316
Post-translational modifications:
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity1
The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressoractivity on IRF1 and diminishes its ability to activate ISRE and H4 promoter1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P14316
IRF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002190.2
ENSEMBL proteins: ENSP00000377218 ENSP00000421927 ENSP00000423074 ENSP00000427204 ENSP00000424475 ENSP00000424552 ENSP00000422860 ENSP00000423506 ENSP00000425037 Reactome Protein details: P14316
Human Recombinant Protein Products for IRF2:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
IRF2 for ontologies About GeneDecksing
IRF2 Antibody Products:
Assay Products for IRF2: |
Protein
Domains /
Families
for IRF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IRF2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P14316ProtoNet protein and cluster: P14316 1 Blocks protein family: IPB001346 Interferon regulatory factor
UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316Similarity: Belongs to the IRF familySimilarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain |
Function
for IRF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IRF2_HUMAN, P14316Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (theinterferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes includingH4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation throughbinding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1transcriptional activationInduction: By viruses and IFN Genatlas biochemistry entry for IRF2:interferon regulatory factor 2,induced in IFN-stimulated cells,protooncogene,repressor of IRF1
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IRF2 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for IRF2:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Irf2):
IRF2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Irf2tm1Mak for IRF2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IRF2 (NM_002199) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2 |
|
Pathways & Interactions
for IRF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytokine Signaling in Immune system | | | 2 | Expression of IFN-induced genes | | | 3 | Interferon gamma signaling | | | 4 | Regulation of IFNA signaling | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for IRF2
1 
Cell Signaling Technology (CST) Pathway for IRF2
1  GeneGo (Thomson Reuters) Pathway for IRF2
2  BioSystems Pathways for IRF2
5/9 
Reactome Pathways for IRF2 (see all 9)
IRF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/87 Interacting proteins for IRF2 (P143161, 3 ENSP000003772184) via UniProtKB, MINT, STRING, and/or I2D (see all 87)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ATG7 | O953521, 3, ENSP000003464374 | EBI-3918980,EBI-987834 I2D:
score=1 STRING: ENSP00000346437 | | FOXK2 | Q011671, 3, ENSP000003356774 | EBI-3918980,EBI-2509991 I2D:
score=1 STRING: ENSP00000335677 | | PPP3CB | P162981, 3, ENSP000003783064 | EBI-3918980,EBI-1759540 I2D:
score=1 STRING: ENSP00000378306 | | FOXK1 | P850371, 3, ENSP000003287204 | EBI-3918980,EBI-2509974 I2D:
score=1 STRING: ENSP00000328720 | | IRF8 | Q025563, ENSP000002686384 | I2D:
score=4 STRING: ENSP00000268638 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
IRF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for IRF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IRF2 for compounds About GeneDecksing
 Browse Tocris compounds for IRF2
9 Novoseek chemical compound relationships for IRF2 gene About this table
Search CenterWatch for drugs/clinical trials and news about IRF2
|
Transcripts
for IRF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRF2 gene: NM_002199.3 Unigene Cluster for IRF2: Interferon regulatory factor 2 Hs.654566 [show with all ESTs]Unigene Representative Sequence: BX64893410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393593(uc003iwf.4) ENST00000505067 ENST00000502750 ENST00000507523
ENST00000512020 ENST00000510814 ENST00000506230 ENST00000505316 ENST00000509274
ENST00000504340
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IRF2 (NM_002199) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2 |
Additional cDNA sequence: AK312953.1 BC015803.2 BT007264.1 BX648934.1 CR457077.1 DQ409328.1 X15949.1 14 DOTS entries: DT.215977 DT.100026528 DT.100778122 DT.99999379 DT.100753213 DT.87078908 DT.121273334 DT.121273344 DT.121273348 DT.121273353 DT.121273358 DT.40117371 DT.95287940 DT.121273326 24/197 AceView cDNA sequences (see all 197): BT007264 CA444409 AA361545 AA857728 AI026022 BX108874 AA416883 AA587279 AA426109 BM807472 W90683 AW162519 CD672836 AA346665 AA502374 CR457077 BM802791 BM995971 BU742880 AW160651 AI817424 AI872657 BU681234 AW951165
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IRF2 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IRF2
|
Expression
for IRF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCAATCAG
About this image
See IRF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRF2
SOURCE GeneReport for Unigene cluster: Hs.654566
UniProtKB/Swiss-Prot: IRF2_HUMAN, P14316Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria
SABiosciences Expression via Pathway-Focused PCR Arrays including IRF2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2 |
Orthologs
for IRF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IRF2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
IRF21 |
interferon regulatory factor 2 |
80.06(n)
84.68(a) |
|
396115 NM_205196.1 NP_990527.1 |
lizard
(Anolis carolinensis) |
Reptilia |
IRF26 |
-- |
76(a) |
1 ↔ 1 |
5(113366779-113387422) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.326032 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.53(n) |
|
BJ029497.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
irf2a1 |
interferon regulatory factor 2a |
71.93(n)
77.44(a) |
|
325410 NM_207054.1 NP_996937.1 |
ENSEMBL Gene Tree for IRF2 (if available)
TreeFam Gene Tree for IRF2 (if available) |
Paralogs
for IRF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IRF2 gene
- IRF82 IRF52 IRF32 IRF42 IRF92 IRF12 IRF72 IRF62
18/80 SIMAP similar genes for IRF2 using alignment to 9 protein entries: IRF2_HUMAN (see all proteins)
(see all similar genes):SLC35E3 BRF2 RAD51 HINFP RRM2B TGM4
PFKFB3 ARL6IP5 BEAN1 CDK10 ATF1 TUBA1C
ADCK1 RQCD1 SH2B3 C1orf143 KIAA1651 SLMO1
IRF2 for paralogs About GeneDecksing
|
Genomic Variants
for IRF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRF2 (185308867 - 185395734 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for IRF2
1 CNV: 4423
2 Indels: 68864 51347
Human Gene Mutation Database (HGMD): IRF2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF2 |
|
Disorders
/ Diseases
for IRF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRF2 for disorders About GeneDecksing
OMIM gene information: 147576
OMIM disorders: --
20/35  diseases for IRF2 (see all 35): About MalaCardsjuvenile myelomonocytic leukemia bullous pemphigoid myelomonocytic leukemia mumps
myeloid leukemia atopic dermatitis acute myeloid leukemia skin disease
carcinoid tumors multiple myeloma multiple sclerosis dermatitis
hepatitis c leukemia psoriasis breast carcinoma
atopy hepatitis b breast cancer myeloma
10/15 Novoseek disease relationships for IRF2 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hematopoietic malignancies |
34.8 |
1 |
7687740 (1) |
| virus infection |
28.7 |
6 |
11090630 (2), 10094406 (1), 9251759 (1), 11721886 (1) |
| psoriasis |
23.3 |
15 |
14962090 (4), 15086546 (4), 12474233 (3) |
| mumps |
20.4 |
1 |
8981353 (1) |
| pancreatic tumor |
15.3 |
6 |
10956389 (3), 10557076 (1) |
| tumors |
12 |
36 |
11323500 (3), 16241857 (2), 10956389 (2), 9251759 (2) (see all 16) |
| solid tumor |
11.1 |
1 |
19170204 (1) |
| carcinoid |
5.34 |
5 |
10942060 (5) |
| skin diseases |
5.07 |
2 |
14962090 (1) |
| breast carcinoma |
2.53 |
3 |
14565859 (1), 16241857 (1) |
Genetic Association Database (GAD): IRF2
Human Genome Epidemiology (HuGE) Navigator: IRF2 (8 documents)
Export disorders for IRF2 gene to outside databases
|
Publications
for IRF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRF2 gene, integrated from 9 sources (see all 177):
(articles sorted by number of sources associating them with IRF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evaluation of the IRF-2 gene as a candidate for PSORS3. (PubMed id 14962090)1, 4, 9 Foerster J....te Meerman G. (2004)
- Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PubMed id 11025449)1, 2, 9 Staal A.... van Wijnen A.J. (2000)
- Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. (PubMed id 11721886)1, 4, 9 Nishio Y....Arinami T. (2001)
- Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region. (PubMed id 8106512)1, 2, 9 Cha Y. and Deisseroth A.B. (1994)
- Identification of novel co-repressor molecules for interferon regulatory factor-2. (PubMed id 12799427)1, 2, 9 Childs K.S. and Goodbourn S. (2003)
- Regulation of IRF2 transcriptional activity by its sumoylation. (PubMed id 18514056)1, 2, 9 Han K.-J.... Shu H.-B. (2008)
- The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes. (PubMed id 9540062)1, 2, 9 Aziz F.... Stein G.S. (1998)
- Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up- regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. (PubMed id 15226432)1, 2, 9 Oshima S....Watanabe M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. (PubMed id 2475256)1, 3 Harada H....Taniguchi T. (1989)
|
External Searches for IRF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing IRF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing IRF2 gene
(According to HUGE)
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Specialized Databases showing IRF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for IRF2 gene:
Search GeneIP for patents involving IRF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IRF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for IRF2 | | OriGene shRNA RFP for IRF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF2 | | | OriGene Protein Over-expression Lysate for IRF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IRF2 | | OriGene 3'-UTR Clone for IRF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IRF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IRF2 | | OriGene Custom Protein Services for IRF2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF2 |
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| | Antibodies & Assays for IRF2 |
| | | | Search Tocris compounds for IRF2 |
| |  |  |  |  | | | | | | Recombinant Protein for IRF2 |
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 | | | IRF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF2 |
|  |  |  |  | | | | ThermoFisher Antibodies for IRF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF2 |
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