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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRF1 Gene

protein-coding   GIFtS: 66
GCID: GC05M131817

interferon regulatory factor 1
 Explore 103 diseases affiliated with
IRF1 via
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our new
 Human Malady Compendium 
Biological research products
for IRF1    

Aliases
for IRF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interferon Regulatory Factor 11 2
MAR1 2 5
IRF-12 3

External Ids:    HGNC: 61161   Entrez Gene: 36592   Ensembl: ENSG000001253477   OMIM: 1475755   UniProtKB: P109143   

Export aliases for IRF1 gene to outside databases

Previous GC identifers: GC05M131340 GC05M132265 GC05M131849 GC05M131894 GC05M131846 GC05M127009


Summaries
for IRF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRF1:
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family.
IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required
for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by
interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and
tumor-suppressoion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IRF1_HUMAN, P10914
Function: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular
responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial
infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell
proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell
death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific
target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an
interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation
activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2,
PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such
as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7,
IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression,
such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes
involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune
response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment
of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting
NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also
implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg)
cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in
stimulating an immune response against tumor cells

Gene Wiki entry for IRF1


Genomic Views
for IRF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRF1 gene promoter:
         STAT1   IRF-7A   STAT1beta   C/EBPalpha   STAT1alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

IRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M131817:  view genomic region     (about GC identifiers)

Start:
 131,817,301 bp from pter      End:
 131,826,490 bp from pter
Size:
 9,190 bases      Orientation:
 minus strand

Proteins
for IRF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRF1_HUMAN, P10914 (See protein sequence)
Recommended Name: Interferon regulatory factor 1  
Size: 325 amino acids; 36502 Da
Subunit: Monomer. Homodimer. Interacts with MYD88 and PIAS3 (By similarity). Interacts with EP300
Subcellular location: Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than
non-MYD88-associated IRF1
Miscellaneous: Deletion or rearrangement of IRF1 are found in preleukemic myelodysplastic syndrome (MDS) and acute
myelogenous leukemia (AML)
Secondary accessions: Q96GG7

Explore the universe of human proteins at neXtProt for IRF1: NX_P10914

Post-translational modifications:

  • Phosphorylated by CK2 and this positively regulates its activity1
  • Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates
    • the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3
    (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites1
  • Ubiquitinated. Appears to compete with sumoylation on C-terminal sites1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10914

    • IRF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002189.1  
    ENSEMBL proteins: 
     ENSP00000245414   ENSP00000384406   ENSP00000405655   ENSP00000396318   ENSP00000392455  
    Reactome Protein details: P10914
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: IRF1
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    Novus Biologicals IRF1 Proteins
    Novus Biologicals IRF1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for IRF1
    Uscn Proteins for IRF1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA18035482
    GO:0005634nucleus TAS11846971
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--


    IRF1 for ontologies           About GeneDecksing



    IRF1 Antibody Products: 
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    Assay Products for IRF1: 
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    Uscn ELISAs and CLIAs for IRF1

    Protein Domains /
    Families
    for IRF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRF1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017431 Interferon_reg_fac-1/2
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR019817 Interferon_reg_fac_CS

    Graphical View of Domain Structure for InterPro Entry P10914

    ProtoNet protein and cluster: P10914

    1 Blocks protein family: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF1_HUMAN, P10914
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    Function
    for IRF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRF1_HUMAN, P10914
    Function: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular
    responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial
    infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell
    proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell
    death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific
    target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an
    interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation
    activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2,
    PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such
    as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7,
    IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression,
    such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes
    involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune
    response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment
    of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting
    NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also
    implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg)
    cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in
    stimulating an immune response against tumor cells
    Enzyme regulation: Activated by MYD88 (By similarity)
    Induction: By viruses and interferon (IFN)

         Genatlas biochemistry entry for IRF1:
    interferon regulatory factor 1,transcriptional activator for IFNA,IFNB and IFN-stimulated genes,a modulator of
    virus-induced signaling,antioncogene deleted in MDS,AML,differentiated gastric adenocarcinomas (see TSG5D),tumor
    suppressor transcription factor inducing apoptosis of tumorigenic cell lines

    10/502 SABiosciences Target genes for IRF1 (see all 502):
    ACAA1 ACRBP ACTRT2 ACVR1B ACYP1 ADAM17 ADAM8 AGPAT4 AGTR2 AKAP11

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IRF1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRF1
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate IRF1 (see all 81):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-642a hsa-miR-3194-5p hsa-miR-106a hsa-miR-342-3p hsa-miR-3122 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: IRF1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF1 (see all 7)
    OriGene shRNA RFP: IRF1
    OriGene siRNA: IRF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRF1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF1 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: IRF1 (NM_002198)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF1 

    Cell Line
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    Search LifeMap BioReagents cell lines for IRF1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding ----
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA18035482
    GO:0003677DNA binding TAS11846971
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI15509808


    IRF1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for IRF1:
     Elongated cells  Enable proliferation in B-Raf   Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for IRF1: Irf1tm1Mak Irf1tm1Cwe
         11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Irf1):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  normal  renal/urinary system  skeleton 
     tumorigenesis 

    IRF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Prolactin receptor signaling
    		Development_Prolactin receptor signaling1.00
    		Prolactin Signaling Pathway0.39
    		Development Prolactin receptor signaling1.00
    2Immune response_IFN gamma signaling pathway
    		Immune response_IFN gamma signaling pathway1.00
    		IFN-gamma pathway0.43
    		Immune response IFN gamma signaling pathway1.00
    3Immune response_IL-1 signaling pathway
    		Immune response_IL-1 signaling pathway1.00
    		Immune response IL-1 signaling pathway0.98
    4Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		Bacterial infections in CF airways0.78
    5Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for IRF1
        Immune response IFN gamma signaling pathway
    Immune response IFN alpha/beta signaling pathway
    Development Prolactin receptor signaling
    Immune response IL-1 signaling pathway
    Immune response IL-12 signaling pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IRF1
        iNOS Signaling

    1 Cell Signaling Technology (CST) Pathway for IRF1
        NF-kappaB Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for IRF1 (see all 7)
        Immune response Bacterial infections in normal airways
    Development Prolactin receptor signaling
    Immune response IL-12 signaling pathway
    Immune response IFN gamma signaling pathway
    Bacterial infections in CF airways

    5/10 BioSystems Pathways for IRF1 (see all 10) 
        Apoptosis
    Senescence and Autophagy
    Type II interferon signaling (IFNG)
    IL-7 Signaling Pathway
    Prolactin Signaling Pathway

    5/9        Reactome Pathways for IRF1 (see all 9)
        Hemostasis
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Cytokine Signaling in Immune system
    Expression of IFN-induced genes


    2         Kegg Pathways  (Kegg details for IRF1):
        Pertussis
    Hepatitis C


    IRF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/109 Interacting proteins for IRF1 (P109142, 3 ENSP000002454144) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF8Q025563, ENSP000002686384I2D: score=5 STRING: ENSP00000268638
    RELAQ042063, ENSP000003842734I2D: score=4 STRING: ENSP00000384273
    STAT1P422243, ENSP000003543944I2D: score=4 STRING: ENSP00000354394
    HMGA1P170963, ENSP000003082274I2D: score=3 STRING: ENSP00000308227
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002819regulation of adaptive immune response TAS11846971
    GO:0006351transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS2475256
    GO:0006468protein phosphorylation IDA10094406
    GO:0006473protein acetylation IDA--


    IRF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRF1
    10/44 Novoseek chemical compound relationships for IRF1 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 70.4 9 15516717 (1), 8704165 (1), 8265581 (1), 10074208 (1) (see all 8)
    ifn-alpha 66.8 15 17617740 (2), 15077162 (1), 12967644 (1), 20457620 (1) (see all 8)
    indoleamine 63 5 16672265 (2), 15494045 (1), 8663541 (1)
    am 580 51.7 6 16636311 (2), 16085646 (1)
    retinoic acid 47.7 78 8704165 (6), 12204966 (5), 16636311 (5), 16085646 (5) (see all 22)
    poly(i-c) 44.5 3 8027591 (2), 9858321 (1)
    tyrosine 39.6 18 11483597 (4), 9092512 (2), 11804954 (2), 10404396 (1) (see all 8)
    rantes 38 10 16707500 (3), 11390609 (2), 10713367 (1), 12165487 (1) (see all 6)
    pdtc 36.7 3 11739238 (1), 16284791 (1), 12704788 (1)
    polyinosinic-polycytidylic acid 36.2 1 1371248 (1)

    Search CenterWatch for drugs/clinical trials and news about IRF1 

    Transcripts
    for IRF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRF1 gene: 
    NM_002198.2  

    Unigene Cluster for IRF1:

    Interferon regulatory factor 1
    Hs.436061  [show with all ESTs]
    Unigene Representative Sequence: NM_002198
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000245414(uc003kxa.2 uc003kxb.2) ENST00000472045 ENST00000405885(uc010jdt.2)
    ENST00000437654(uc003kxd.2) ENST00000459982 ENST00000458069 ENST00000463784
    ENST00000439555 ENST00000476613 ENST00000493208

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRF1
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate IRF1 (see all 81):
    hsa-miR-548j hsa-miR-3678-3p hsa-miR-642a hsa-miR-3194-5p hsa-miR-106a hsa-miR-342-3p hsa-miR-3122 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: IRF1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF1 (see all 7)
    OriGene shRNA RFP: IRF1
    OriGene siRNA: IRF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF1
    Clone
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    GenScript: all cDNA clones in your preferred vector: IRF1 (NM_002198)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF1

    Additional cDNA sequence: 

    AB103081.1 AK314025.1 BC009483.2 BT019755.1 BT019756.1 CR541713.1 X14454.1 

    11 DOTS entries:

    DT.206801  DT.456117  DT.95103231  DT.95335564  DT.120846032  DT.120846289  DT.95188797  DT.100787015 
    DT.120846039  DT.95272124  DT.95272134 

    24/351 AceView cDNA sequences (see all 351):

    BI822732 BE745255 BQ947930 BQ710237 BG754065 AW167090 BG924491 BI962874 
    BQ960301 BX335394 BU500602 BM747007 BQ054218 BF974277 BI835499 BQ949894 
    BX099146 BM747637 BQ053272 BM782704 BQ436635 BM917683 BQ707680 AW102930 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IRF1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
    SP1:                                -     -                                               -                 -                           
    SP2:                          -     -     -                                               -                 -                           
    SP3:                                -     -                                               -     -                                       
    SP4:                                -     -                                               -                                             
    SP5:                                -                                                                                                   


    ECgene alternative splicing isoforms for IRF1

    Expression
    for IRF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGAACACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IRF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRF1

    SOURCE GeneReport for Unigene cluster: Hs.436061
        SABiosciences Expression via Pathway-Focused PCR Arrays including IRF1 (see all 13): 
              HIV Host Response in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Interferons & Receptors in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IRF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IRF1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Irf11 , 5 interferon regulatory factor 11, 5 84.41(n)1
    85.54(a)1    		   11 (32.00 cM)5
    163621  NM_001159396.11  NP_001152868.11 
     537700145 
    chicken
    (Gallus gallus)    		 Aves IRF11 interferon regulatory factor 1 69.27(n)
    64.17(a)    		   396384  NM_205415.1  NP_990746.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IRF16
    		 --
    		 51(a)
    		 1 ↔ 1
    		 2(127764582-127772440)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686912 hypothetical protein MGC68691 74.53(n)    BC059984.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AY398364.12   -- 75.91(n)    AY398364.1 


    ENSEMBL Gene Tree for IRF1 (if available)
    TreeFam Gene Tree for IRF1 (if available) 

    Paralogs
    for IRF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRF1 gene
    IRF82  IRF22  IRF52  IRF32  IRF42  IRF92  IRF72  IRF62  
    5 SIMAP similar genes for IRF1 using alignment to 6 protein entries:     IRF1_HUMAN (see all proteins):
    IRF2    IRF4    IRF8    IRF9    IRF5

    IRF1 for paralogs           About GeneDecksing



    Genomic Variants
    for IRF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in IRF1 are shown (see all 227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs780357711,2
    		F,--127009082(+) CCAGCC/TTACCT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1133269271,2
    		C,--127010007(+) GAGACT/AAAGTC 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs351781181,2
    		F--127011368(-) CCTTCG/AGGGCR 1 -- ut315Minor allele frequency- A:0.01MN 400
    rs356423381,2
    		F--127011434(-) TACCCC/GCTTTT 1 -- ut315Minor allele frequency- G:0.01MN 400
    rs178484291,2
    		C,F,H,--127011436(-) ACTACA/C/TCCCTT 2 -- ut31 ese3 trp33CSA NS 586
    rs348507711,2
    		C,F,--127011452(-) ATCTCG/ATTCCC 1 -- ut317Minor allele frequency- A:0.01MN WA 520
    rs178484281,2
    		C,F,--127011499(-) CCAATC/TCCAGG 1 -- ut31 ese38Minor allele frequency- T:0.03CSA MN WA 592
    rs178484271,2
    		C,F,--127011738(-) CCCTCC/TTTGGG 1 -- ut31 trp31Minor allele frequency- T:0.03CSA 72
    rs1132570451,2
    		C--127012036(+) AGGGTG/AGGGGA 1 -- int11Minor allele frequency- A:0.00CSA 1
    rs415022461,2
    		F--127012163(-) AATTAG/TCTACG 1 -- int11Minor allele frequency- T:0.08EU 78

    HapMap Linkage Disequilibrium report for IRF1 (131817301 - 131826490 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IRF1: --
    Human Gene Mutation Database (HGMD): IRF1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF1
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF1

    Disorders / Diseases
    for IRF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRF1 for disorders           About GeneDecksing

    OMIM gene information: 147575   
    OMIM disorders: 137215  211980  
    UniProtKB/Swiss-Prot: IRF1_HUMAN, P10914
  • Defects in IRF1 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or
    • stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the
    small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to
    other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that
    accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and
    intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of
    the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal
    metaplasia of the stomach, most often observed in sporadic disease

    20/103 diseases for IRF1 (see all 103):    About MalaCards
    subacute sclerosing panencephalitis    nonsmall cell lung cancer, somatic    myelodysplastic syndrome, preleukemic    familial adenomatous polyposis
    graft versus host disease    lung cancer, somatic    dengue hemorrhagic fever    juvenile myelomonocytic leukemia
    hemorrhagic fever    gastric cancer, somatic    inflammatory bowel disease    myelodysplastic syndrome
    newcastle disease    bullous pemphigoid    myelomonocytic leukemia    herpes simplex
    fanconi's anemia    venous malformations    b-cell lymphomas    mumps

    1 disease from the University of Copenhagen DISEASES database for IRF1:
    Cancer

    10/76 Novoseek disease relationships for IRF1 gene (see all 76)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 47.2 150 15149633 (5), 11323500 (4), 16241857 (4), 15241475 (3) (see all 72)
    necrosis 44.3 17 14708625 (3), 9251759 (2), 14729660 (1), 11096458 (1) (see all 12)
    virus infection 43.6 16 10094406 (1), 15378396 (1), 9251759 (1), 11904369 (1) (see all 13)
    leukemia promyelocytic acute 39.5 3 10602416 (2), 16914093 (1)
    myelodysplastic syndromes 38.9 10 9315094 (1), 10807049 (1), 8809574 (1), 12358902 (1) (see all 6)
    hematopoietic malignancies 31.4 5 7687740 (1), 8625321 (1), 7936656 (1), 9865486 (1)
    leukemogenesis 30.4 3 10921095 (1), 10609788 (1)
    inflammation 30.4 18 19443641 (3), 10498899 (2), 17532542 (1), 12677441 (1) (see all 10)
    leukemia 29.6 26 10921095 (3), 8438156 (3), 8622878 (3), 8809574 (2) (see all 14)
    fanconis anemia 25.8 2 19129219 (1)

    Genetic Association Database (GAD): IRF1
    Human Genome Epidemiology (HuGE) Navigator: IRF1 (48 documents)

    Export disorders for IRF1 gene to outside databases

    Publications
    for IRF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRF1 gene, integrated from 9 sources (see all 662):
    (articles sorted by number of sources associating them with IRF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a cDNA coding for human IRF-1. (PubMed id 2726461)1, 2, 3 Maruyama M.... Taniguchi T. (1989)
    2. A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity. (PubMed id 10094406)1, 2, 9 Lin R. and Hiscott J. (1999)
    3. Mutation screening of interferon regulatory factor 1 gene (IRF-1) as a candidate gene for atopy/asthma. (PubMed id 11069564)1, 4, 9 Noguchi E....Hamaguchi H. (2000)
    4. Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. (PubMed id 15509808)1, 2, 9 Dornan D....Ball K.L. (2004)
    5. Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression. (PubMed id 17516545)1, 2, 9 Su Z.Z....Fisher P.B. (2007)
    6. Human interferon regulatory factor 1: intron-exon organization. (PubMed id 1382447)1, 2, 9 Cha Y.... Deisseroth A.B. (1992)
    7. Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. (PubMed id 9679752)1, 2, 9 Nozawa H....Tanaka N. (1998)
    8. Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages. (PubMed id 19404407)1, 2, 9 Huang Y....Zheng J.C. (2009)
    9. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up- regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. (PubMed id 15226432)1, 2, 9 Oshima S....Watanabe M. (2004)
    10. Gene-gene and gene-environmental interactions of p53, p21, and IRF-1 polymorphisms in Korean women with cervix cancer. (PubMed id 14764039)1, 4, 9 Lee J.E....Park J.S. (2004)

    External Searches for IRF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IRF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3659 HGNC: 6116 AceView: IRF1 Ensembl:ENSG00000125347 euGenes: HUgn3659
    ECgene: IRF1 Kegg: 3659 H-InvDB: IRF1

    Other Databases showing IRF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IRF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IRF1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IRF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IRF1 gene:
    Search GeneIP for patents involving IRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IRF1 gene

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    About This Section

     
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