Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IREB2 Gene

protein-coding   GIFtS: 60
GCID: GC15P078730

Iron-Responsive Element Binding Protein 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Iron-Responsive Element Binding Protein 21 2     ACO32
Iron Regulatory Protein 22 3     IRP2AD2
IRP22 3     Iron-Responsive Element-Binding Protein 22
IRE-BP 22 3     EC 4.2.1.38

External Ids:    HGNC: 61151   Entrez Gene: 36582   Ensembl: ENSG000001363817   OMIM: 1475825   UniProtKB: P482003   

Export aliases for IREB2 gene to outside databases

Previous GC identifers: GC15P074809 GC15P071820 GC15P076306 GC15P076446 GC15P076517 GC15P055487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IREB2 Gene: 
IREB2 (iron-responsive element binding protein 2) is a protein-coding gene. Diseases associated with IREB2 include erythropoietic protoporphyria, and hallervorden-spatz syndrome. GO annotations related to this gene include iron-responsive element binding and RNA binding. An important paralog of this gene is ACO1.

UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200
Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found
in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin
receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding
of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IREB2 gene promoter:
         Bach1   p53   AML1a   ATF-2   Lmo2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIREB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IREB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IREB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

IREB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IREB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P078730:  view genomic region     (about GC identifiers)

Start:
78,729,773 bp from pter      End:
78,793,798 bp from pter
Size:
64,026 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200 (See protein sequence)
Recommended Name: Iron-responsive element-binding protein 2  
Size: 963 amino acids; 105045 Da
Cofactor: Binds 1 4Fe-4S cluster per subunit (By similarity). 4Fe-4S-binding affects RNA-binding activity, thereby
inhibiting activity of the protein (By similarity)
Subunit: Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions. Interacts (when associated
with the 4Fe-4S) with FBXL5
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA79926.1; Type=Frameshift; Positions=605, 611; Sequence=BAD92640.1; Type=Frameshift;
Positions=727;
Secondary accessions: A8KAC7 Q13095 Q1HE21 Q59FQ7 Q9UF17

Explore the universe of human proteins at neXtProt for IREB2: NX_P48200

Explore proteomics data for IREB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF
    complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and
    allowing its RNA-binding activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48200

  • 4/5 DME Specific Peptides for IREB2 (P48200) (see all 5)
     GPKRPQD  ANYLASP  SIRVLLE  TTDHISPAG 

    IREB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IREB2 Protein Expression
    REFSEQ proteins: NP_004127.1  
    ENSEMBL proteins: 
     ENSP00000453172   ENSP00000453532   ENSP00000258886   ENSP00000453058   ENSP00000452938  
     ENSP00000454063   ENSP00000453863  

    Human Recombinant Protein Products for IREB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IREB2
    OriGene Protein Over-expression Lysate for IREB2
    OriGene MassSpec for IREB2 
    OriGene Custom Protein Services for IREB2
    GenScript Custom Purified and Recombinant Proteins Services for IREB2
    Novus Biologicals IREB2 Protein
    Novus Biologicals IREB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IREB2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS7983023
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--

    IREB2 for ontologies           About GeneDecksing



    IREB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IREB2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for IREB2
    OriGene Custom Antibody Services for IREB2
    GenScript Custom Superior Antibodies Services for IREB2
    Novus Biologicals IREB2 Antibodies
    Abcam antibodies for IREB2
    Cloud-Clone Corp. Antibodies for IREB2 
    ThermoFisher Antibodies for IREB2
    LSBio Antibodies in human, mouse, rat for IREB2 

    Assay Products for IREB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IREB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IREB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IREB2 
    Cloud-Clone Corp. CLIAs for IREB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR000573 AconitaseA/IPMdHydase_ssu_swvl
     IPR015932 Aconitase/IPMdHydase_lsu_aba_2
     IPR015937 Acoase/IPM_deHydtase
     IPR001030 Acoase/IPM_deHydtase_lsu_aba
     IPR018136 Aconitase_4Fe-4S_BS

    Graphical View of Domain Structure for InterPro Entry P48200

    ProtoNet protein and cluster: P48200

    1 Blocks protein domain: IPB000573 Aconitate hydratase

    UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200
    Similarity: Belongs to the aconitase/IPM isomerase family


    IREB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IREB2_HUMAN, P48200
    Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found
    in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin
    receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding
    of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA

         Genatlas biochemistry entry for IREB2:
    iron responsive element binding protein 2,structurally related to aconitase

         Enzyme Number (IUBMB): EC 4.2.1.32

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9924025
    GO:0005515protein binding IPI19762596
    GO:0030350iron-responsive element binding TAS9924025
    GO:0046872metal ion binding IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--
         
    IREB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IREB2:
     Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ireb2):
     behavior/neurological  digestive/alimentary  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  normal 
     skeleton 

    IREB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IREB2: Ireb2tm1Roua Ireb2tm1.2Mwh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IREB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IREB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IREB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IREB2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IREB2
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate IREB2 (see all 75):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4267 hsa-miR-490-5p hsa-miR-374b* hsa-miR-3065-5p hsa-miR-548o hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IREB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IREB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IREB2
    Sirion Biotech Customized adenovirus for overexpression of IREB2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IREB2 (see all 7)
    OriGene ORF clones in mouse, rat for IREB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IREB2 (NM_004136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IREB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IREB2
    Sirion Biotech Customized lentivirus for stable overexpression of IREB2 
                         Customized lentivirus expression plasmids for stable overexpression of IREB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IREB2
    Search LifeMap BioReagents cell lines for IREB2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IREB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IREB2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Iron metabolism in placenta
    Iron metabolism in placenta
    2Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    2 BioSystems Pathways for IREB2
        Iron metabolism in placenta
    Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IREB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for IREB2 (P482003 ENSP000002588864) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBCK1Q9BYM83, ENSP000003486324I2D: score=2 STRING: ENSP00000348632
    FBXL5Q9UKA13, ENSP000003448664I2D: score=1 STRING: ENSP00000344866
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    YBX1P678093, ENSP000003616264I2D: score=3 STRING: ENSP00000361626
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0006782protoporphyrinogen IX biosynthetic process IEA--
    GO:0006826iron ion transport TAS9924025
    GO:0006879cellular iron ion homeostasis IEA--
    GO:0007568aging IEA--

    IREB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IREB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IREB2

    1 HMDB Compound for IREB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--

    10/24 Novoseek inferred chemical compound relationships for IREB2 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 83.9 469 17822790 (10), 12972033 (9), 7665579 (8), 12888568 (7) (see all 99)
    iron-sulfur 72.3 1 11981450 (1)
    ferric ammonium citrate 69.3 4 16479012 (3)
    succinylacetone 59.5 2 12972033 (1), 16479012 (1)
    5-aminolevulinic acid 50.2 2 11741608 (1), 10522551 (1)
    n acetylcysteine 38.8 2 18073202 (1), 14729944 (1)
    cysteine 38.4 7 12972033 (2), 10484662 (1), 19223469 (1), 14729944 (1) (see all 5)
    citrate 37.3 1 17095152 (1)
    oxygen 35.5 11 12888568 (3), 11981450 (1), 10440237 (1), 12629548 (1) (see all 5)
    fe3+ 33 1 19454487 (1)

    Search CenterWatch for drugs/clinical trials and news about IREB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IREB2 gene: 
    NM_004136.2  

    Unigene Cluster for IREB2:

    Iron-responsive element binding protein 2
    Hs.436031  [show with all ESTs]
    Unigene Representative Sequence: NM_004136
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560840 ENST00000559215 ENST00000258886(uc002bdr.2 uc010unb.1)
    ENST00000558525 ENST00000560440(uc002bdq.3) ENST00000558570 ENST00000560454
    ENST00000559427 ENST00000559676 ENST00000559091

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IREB2
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate IREB2 (see all 75):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4267 hsa-miR-490-5p hsa-miR-374b* hsa-miR-3065-5p hsa-miR-548o hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IREB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IREB2
    Clone
    Products:
         
    OriGene clones in human, mouse for IREB2 (see all 7)
    OriGene ORF clones in mouse, rat for IREB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IREB2 (NM_004136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IREB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IREB2
    Sirion Biotech Customized lentivirus for stable overexpression of IREB2 
                         Customized lentivirus expression plasmids for stable overexpression of IREB2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IREB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IREB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IREB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IREB2

    Additional mRNA sequence: 

    AB209403.1 AB586699.1 AF147302.1 AK027033.1 AK027034.1 AK292992.1 AL117613.1 AL133439.1 
    BC017880.1 BC117481.1 BC117483.1 BC143948.1 M58511.1 U20180.1 

    14 DOTS entries:

    DT.212937  DT.312198  DT.203551  DT.91947945  DT.100706425  DT.121068179  DT.91976641  DT.100779763 
    DT.95316350  DT.95372714  DT.100688057  DT.100713326  DT.40245042  DT.95280843 

    24/230 AceView cDNA sequences (see all 230):

    AW501082 AA747433 N66042 AI499408 N94143 AI570117 BQ425239 BX340905 
    BM754995 N73405 CR610815 AA344229 AW615210 AI272895 AA947739 CN483934 
    AW841838 AI672118 BM971831 BM698206 AF147302 AA406258 AA693339 AW150637 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IREB2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
    SP1:              -                                         -                 -                                                                                 
    SP2:              -                                         -                                                                                                   
    SP3:              -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:        -     -                                                                                                                                             

    ExUns: 24a · 24b ^ 25
    SP1:        -         
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for IREB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IREB2 expression in normal human tissues (normalized intensities)      IREB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGACATTTG
    IREB2 Expression
    About this image


    IREB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             cd14+ cells   
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad

    See IREB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IREB2

    SOURCE GeneReport for Unigene cluster: Hs.436031
        SABiosciences Custom PCR Arrays for IREB2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IREB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IREB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IREB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IREB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IREB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IREB2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ireb21 , 5 iron responsive element binding protein 21, 5 91.36(n)1
    93.96(a)1
      9 (29.81 cM)5
    646021  NM_022655.31  NP_073146.21 
     548637555 
    chicken
    (Gallus gallus)
    Aves IREB21 iron-responsive element binding protein 2 77.55(n)
    82.43(a)
      427490  NM_001031454.1  NP_001026625.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX704259.12   -- 72.58(n)    BX704259.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ireb21 iron-responsive element binding protein 2 64.05(n)
    68.71(a)
      652982  XM_001341755.4  XP_001341791.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Irp-1B6
    Irp-1A6
    Iron regulatory protein 1A
    56(a)
    55(a)
    many ↔ many
    many ↔ many
    3R(6234337-6238638)
    3R(18547042-18550325)
    worm
    (Caenorhabditis elegans)
    Secernentea aco-16
    Probable cytoplasmic aconitate hydratase
    55(a)
    1 → many
    X(11339872-11343568)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ACO16
    Aconitase, required for the tricarboxylic acid (TC...
    21(a)
    1 → many
    XII(735212-737548)


    ENSEMBL Gene Tree for IREB2 (if available)
    TreeFam Gene Tree for IREB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IREB2 gene
    ACO12  
    4 SIMAP similar genes for IREB2 using alignment to 9 protein entries:     IREB2_HUMAN (see all proteins):
    IREB2 variant    DKFZp686P10119    ACO1    IRP1

    IREB2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IREB2
    PGOHUM00000239338 PGOHUM00000239343


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1411 SNPs in IREB2 are shown (see all 1411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0584094
    ----see VAR_0584092 V L mis40--------
    rs21022641,2
    C,F,A--78728608(+) cctgcA/Ggcttt 1 -- us2k1 tfbs37Minor allele frequency- G:0.35NA WA CSA 130
    rs1869848481,2
    --78728629(+) AGTGCC/TGGGAT 1 -- us2k10--------
    rs1391983811,2
    C--78728713(+) ATAAAC/TAGATA 1 -- us2k10--------
    rs789395641,2
    C,F--78728723(+) ACAAGC/TATCTG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs788682131,2
    C--78728939(+) TGAATA/GAAGGA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1919056411,2
    --78729105(+) AGGAGA/GGAAAT 1 -- us2k10--------
    rs1493613151,2
    --78729110(+) GGAAAC/TGACGA 1 -- us2k10--------
    rs1446832461,2
    --78729194(+) CTCCGA/GGTTTA 1 -- us2k10--------
    rs775769491,2
    C,F--78729243(+) AACATA/GTTAAC 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for IREB2 (78729773 - 78793798 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IREB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833063CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IREB2
    DNA2.0 Custom Variant and Variant Library Synthesis for IREB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147582    OMIM disorders: --

    20/30 diseases for IREB2 (see all 30):    About MalaCards
    erythropoietic protoporphyria    hallervorden-spatz syndrome    microcytic anemia    iron deficiency anemia
    sideroblastic anemia    hemochromatosis    restless legs syndrome    friedreich ataxia
    acne    beta thalassemia    alpha 1-antitrypsin deficiency    thalassemia
    sickle cell disease    anemia    parkinson's disease    duodenitis
    age related macular degeneration    cataract    alzheimer's disease    chronic obstructive pulmonary disease


    IREB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for IREB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron overload 63.7 2 12691842 (1), 20364084 (1)
    iron deficiency 62.8 10 18549630 (1), 8668195 (1), 18574241 (1), 15684386 (1)
    hereditary hemochromatosis 45.6 1 16503547 (1)
    neurodegenerative diseases 40.2 5 16850017 (1), 12691842 (1), 11175792 (1)
    parkinson disease 29.5 6 12465072 (3), 15057521 (1)
    iron deficiency anemia 23.4 1 16503547 (1)
    neurodegeneration 20.7 4 15831703 (2), 12691842 (1)
    anemia 10.4 1 16850017 (1)
    cancer lung 0 1 20405006 (1), 15684386 (1), 17760563 (1)
    alzheimers disease 0 2 16914832 (1), 17408857 (1)

    Genetic Association Database (GAD): IREB2
    Human Genome Epidemiology (HuGE) Navigator: IREB2 (9 documents)

    Export disorders for IREB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IREB2 gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with IREB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein. (PubMed id 2172968)1, 2, 3 Rouault T.A.... Klausner R.D. (1990)
    2. Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. (PubMed id 7622457)1, 2, 9 Guo B.... Leibold E.A. (1995)
    3. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. (PubMed id 12629548)1, 2, 9 Yamanaka K.... Iwai K. (2003)
    4. Polymorphisms in iron-responsive binding protein 2 and lack of association with sporadic Parkinson's disease. (PubMed id 12465072)1, 4, 9 Lee P.L....Beutler E. (2002)
    5. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. (PubMed id 16914832)1, 4, 9 Coon K.D....Kirsch W.M. (2006)
    6. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. (PubMed id 7983023)1, 2, 9 Samaniego F.... Klausner R.D. (1994)
    7. Control of iron homeostasis by an iron-regulated ubiquitin ligase. (PubMed id 19762596)1, 2, 9 Vashisht A.A.... Wohlschlegel J.A. (2009)
    8. An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. (PubMed id 19762597)1, 2, 9 Salahudeen A.A.... Bruick R.K. (2009)
    9. A genome-wide association study of COPD identifies a s usceptibility locus on chromosome 19q13. (PubMed id 22080838)1, 4 Cho M.H.... . (2012)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3658 HGNC: 6115 AceView: IREB2 Ensembl:ENSG00000136381 euGenes: HUgn3658
    ECgene: IREB2 H-InvDB: IREB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IREB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IREB2 gene:
    Search GeneIP for patents involving IREB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of IREB2
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IREB2   OriGene RNAi products in human, mouse, rat for IREB2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IREB2  
     OriGene MassSpec something-or-other for IREB2   OriGene clones in human, mouse for IREB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for IREB2   OriGene Purified Protein for IREB2  
     OriGene ORF clones in mouse, rat for IREB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IREB2   OriGene Custom Protein Services for IREB2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IREB2
     QIAGEN SeqTarget long-range PCR primers for resequencing IREB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IREB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IREB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IREB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IREB2
     GenScript Custom Purified and Recombinant Proteins Services for IREB2 GenScript cDNA clones with any tag delivered in your preferred vector for IREB2
     GenScript Custom Assay Services for IREB2 GenScript Custom Superior Antibodies Services for IREB2
     GenScript Custom overexpressing Cell Line Services for IREB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IREB2 promoter
     Search Chromatin IP Primers for IREB2
     RT2 qPCR Primer Assay in human, mouse, rat IREB2
     GNC Network for IREB2
     SABiosciences Custom PCR Arrays for IREB2
     Search Tocris compounds for IREB2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IREB2 antibodies
     IREB2 proteins
     IREB2 lysates
     Antibodies for IREB2
     See all of Abcam's Antibodies, Kits and Proteins for IREB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for IREB2
     Antibodies for IREB2
     ELISAs for IREB2
     CLIAs for IREB2
     Search LifeMap BioReagents cell lines for IREB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IREB2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IREB2
     SwitchGear Promoter luciferase reporter plasmids for IREB2
     ThermoFisher Antibodies for IREB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IREB2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IREB2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IREB2
    Customized:
     lentivirus for stable overexpression of IREB2
     lentivirus expression plasmids for stable overexpression of IREB2
     adenovirus for overexpression of IREB2
     LSBio Antibodies in human, mouse, rat for IREB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IREB2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4