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Aliases for IREB2 Gene

Aliases for IREB2 Gene

  • Iron-Responsive Element Binding Protein 2 2 3
  • Iron Regulatory Protein 2 3 4
  • IRE-BP 2 3 4
  • IRP2 3 4
  • Iron-Responsive Element-Binding Protein 2 3
  • EC 4.2.1.3 63
  • IRP2AD 3
  • ACO3 3

External Ids for IREB2 Gene

Previous GeneCards Identifiers for IREB2 Gene

  • GC15P074809
  • GC15P071820
  • GC15P076306
  • GC15P076446
  • GC15P076517
  • GC15P078730
  • GC15P055487

Summaries for IREB2 Gene

GeneCards Summary for IREB2 Gene

IREB2 (Iron-Responsive Element Binding Protein 2) is a Protein Coding gene. Diseases associated with IREB2 include hyperferritinemia-cataract syndrome. Among its related pathways are Validated targets of C-MYC transcriptional activation and Iron metabolism in placenta. GO annotations related to this gene include RNA binding and iron-responsive element binding. An important paralog of this gene is ACO1.

UniProtKB/Swiss-Prot for IREB2 Gene

  • RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IREB2 Gene

Genomics for IREB2 Gene

Regulatory Elements for IREB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IREB2 Gene

Start:
78,437,431 bp from pter
End:
78,501,456 bp from pter
Size:
64,026 bases
Orientation:
Plus strand

Genomic View for IREB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IREB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IREB2 Gene

Proteins for IREB2 Gene

  • Protein details for IREB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48200-IREB2_HUMAN
    Recommended name:
    Iron-responsive element-binding protein 2
    Protein Accession:
    P48200
    Secondary Accessions:
    • A8KAC7
    • E1CJT9
    • H0YKU0
    • Q13095
    • Q1HE21
    • Q59FQ7
    • Q8WVK6
    • Q9UF17

    Protein attributes for IREB2 Gene

    Size:
    963 amino acids
    Molecular mass:
    105045 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit. [4Fe-4S]-binding affects RNA-binding activity, thereby inhibiting activity of the protein.;
    Quaternary structure:
    • Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions. Interacts (when associated with the 4Fe-4S) with FBXL5.
    SequenceCaution:
    • Sequence=AAA79926.1; Type=Frameshift; Positions=605, 611; Evidence={ECO:0000305}; Sequence=BAD92640.1; Type=Frameshift; Positions=727; Evidence={ECO:0000305};

    Alternative splice isoforms for IREB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IREB2 Gene

Proteomics data for IREB2 Gene at MOPED

Selected DME Specific Peptides for IREB2 Gene

Post-translational modifications for IREB2 Gene

  • Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.
  • Ubiquitination at Lys34, Lys70, Lys72, Lys107, Lys136, Lys152, Lys216, Lys233, Lys404, Lys413, Lys449, Lys461, Lys471, Lys475, Lys611, Lys714, Lys769, Lys803, Lys807, Lys836, Lys847, Lys848, Lys860, Lys868, and Lys880
  • Modification sites at PhosphoSitePlus

Other Protein References for IREB2 Gene

Domains for IREB2 Gene

Suggested Antigen Peptide Sequences for IREB2 Gene

Graphical View of Domain Structure for InterPro Entry

P48200

UniProtKB/Swiss-Prot:

IREB2_HUMAN :
  • P48200
Family:
  • Belongs to the aconitase/IPM isomerase family.
genes like me logo Genes that share domains with IREB2: view

No data available for Gene Families for IREB2 Gene

Function for IREB2 Gene

Molecular function for IREB2 Gene

GENATLAS Biochemistry: iron responsive element binding protein 2,structurally related to aconitase
UniProtKB/Swiss-Prot Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Enzyme Numbers (IUBMB) for IREB2 Gene

Gene Ontology (GO) - Molecular Function for IREB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9924025
GO:0005515 protein binding IPI 19762596
GO:0030350 iron-responsive element binding TAS 9924025
GO:0030371 translation repressor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IREB2: view
genes like me logo Genes that share phenotypes with IREB2: view

Animal Models for IREB2 Gene

MGI Knock Outs for IREB2:

Animal Model Products

CRISPR Products

miRNA for IREB2 Gene

miRTarBase miRNAs that target IREB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IREB2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for IREB2 Gene

Localization for IREB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IREB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IREB2 Gene COMPARTMENTS Subcellular localization image for IREB2 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IREB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 7983023
GO:0005739 mitochondrion --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with IREB2: view

Pathways for IREB2 Gene

genes like me logo Genes that share pathways with IREB2: view

Pathways by source for IREB2 Gene

Gene Ontology (GO) - Biological Process for IREB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation --
GO:0006782 protoporphyrinogen IX biosynthetic process --
GO:0006826 iron ion transport TAS 9924025
GO:0006879 cellular iron ion homeostasis IEA --
GO:0007568 aging --
genes like me logo Genes that share ontologies with IREB2: view

Compounds for IREB2 Gene

(1) HMDB Compounds for IREB2 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6

(24) Novoseek inferred chemical compound relationships for IREB2 Gene

Compound -log(P) Hits PubMed IDs
iron 83.9 216
iron-sulfur 72.3 1
ferric ammonium citrate 69.3 3
succinylacetone 59.5 2
5-aminolevulinic acid 50.2 2
genes like me logo Genes that share compounds with IREB2: view

Transcripts for IREB2 Gene

Unigene Clusters for IREB2 Gene

Iron-responsive element binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IREB2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IREB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IREB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: - -
SP6:
SP7:

ExUns: 24a · 24b ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for IREB2 Gene

GeneLoc Exon Structure for
IREB2
ECgene alternative splicing isoforms for
IREB2

Expression for IREB2 Gene

mRNA expression in normal human tissues for IREB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IREB2 Gene

SOURCE GeneReport for Unigene cluster for IREB2 Gene Hs.436031

genes like me logo Genes that share expressions with IREB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IREB2 Gene

Orthologs for IREB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IREB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IREB2 35
  • 99.83 (n)
  • 99.69 (a)
IREB2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IREB2 35
  • 94.39 (n)
  • 96.12 (a)
IREB2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IREB2 35
  • 88.47 (n)
  • 92.63 (a)
IREB2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ireb2 35
  • 91.36 (n)
  • 93.96 (a)
Ireb2 16
Ireb2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IREB2 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ireb2 35
  • 91.09 (n)
  • 94.07 (a)
chicken
(Gallus gallus)
Aves IREB2 35
  • 77.55 (n)
  • 82.43 (a)
IREB2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ireb2 35
  • 67.55 (n)
  • 68.57 (a)
zebrafish
(Danio rerio)
Actinopterygii ireb2 35
  • 62.47 (n)
  • 66.77 (a)
ireb2 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Irp-1A 36
  • 56 (a)
ManyToMany
Irp-1B 36
  • 57 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea aco-1 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACO2 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.544 36
  • 56 (a)
OneToMany
Species with no ortholog for IREB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IREB2 Gene

ENSEMBL:
Gene Tree for IREB2 (if available)
TreeFam:
Gene Tree for IREB2 (if available)

Paralogs for IREB2 Gene

Paralogs for IREB2 Gene

Pseudogenes.org Pseudogenes for IREB2 Gene

genes like me logo Genes that share paralogs with IREB2: view

Variants for IREB2 Gene

Sequence variations from dbSNP and Humsavar for IREB2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3417 -- 78,501,318(-) ACACT(G/T)TTTTG utr-variant-3-prime
rs13180 -- 78,497,146(+) TTGGC(C/T)GAAAG reference, synonymous-codon
rs905741 -- 78,461,604(-) TCTAA(A/C/T)CATTG intron-variant
rs905742 -- 78,461,133(-) gaaca(C/T)ggaac intron-variant
rs924840 -- 78,439,466(-) ATGTG(A/T)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IREB2 Gene

Variant ID Type Subtype PubMed ID
nsv833063 CNV Loss 17160897

Relevant External Links for IREB2 Gene

HapMap Linkage Disequilibrium report
IREB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IREB2 Gene

Disorders for IREB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IREB2 Gene including...

Search for IREB2 Gene in MalaCards »

(10) Novoseek inferred disease relationships for IREB2 Gene

Disease -log(P) Hits PubMed IDs
iron overload 63.7 2
iron deficiency 62.8 4
hereditary hemochromatosis 45.6 1
neurodegenerative diseases 40.2 3
parkinson disease 29.5 4

Relevant External Links for IREB2

Genetic Association Database (GAD)
IREB2
Human Genome Epidemiology (HuGE) Navigator
IREB2
genes like me logo Genes that share disorders with IREB2: view

No data available for UniProtKB/Swiss-Prot for IREB2 Gene

Publications for IREB2 Gene

  1. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. (PMID: 7983023) Samaniego F. … Klausner R.D. (J. Biol. Chem. 1994) 3 4 23
  2. Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. (PMID: 7622457) Guo B. … Leibold E.A. (J. Biol. Chem. 1995) 3 4 23
  3. Polymorphisms in iron-responsive binding protein 2 and lack of association with sporadic Parkinson's disease. (PMID: 12465072) Lee P.L. … Beutler E. (Mov. Disord. 2002) 3 23 48
  4. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. (PMID: 12629548) Yamanaka K. … Iwai K. (Nat. Cell Biol. 2003) 3 4 23
  5. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. (PMID: 16914832) Coon K.D. … Kirsch W.M. (J. Alzheimers Dis. 2006) 3 23 48

Products for IREB2 Gene

Sources for IREB2 Gene

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