Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IREB2 Gene

protein-coding   GIFtS: 59
GCID: GC15P078730

iron-responsive element binding protein 2
 Explore 32 diseases affiliated with
IREB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IREB2    

Aliases
for IREB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Iron-Responsive Element Binding Protein 21 2     ACO32
IRP21 2 3     IRP2AD2
Iron Regulatory Protein 22 3     Iron-Responsive Element-Binding Protein 22
IRE-BP 22 3     EC 4.2.1.38

External Ids:    HGNC: 61151   Entrez Gene: 36582   Ensembl: ENSG000001363817   OMIM: 1475825   UniProtKB: P482003   

Export aliases for IREB2 gene to outside databases

Previous GC identifers: GC15P074809 GC15P071820 GC15P076306 GC15P076446 GC15P076517 GC15P055487


Summaries
for IREB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200
Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in
the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA.
Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to
the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA




Genomic Views
for IREB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IREB2 gene promoter:
         Bach1   p53   AML1a   ATF-2   Lmo2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IREB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IREB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IREB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC chromosome: 15

IREB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IREB2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P078730:  view genomic region     (about GC identifiers)

Start:
 78,729,773 bp from pter      End:
 78,793,798 bp from pter
Size:
 64,026 bases      Orientation:
 plus strand

Proteins
for IREB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200 (See protein sequence)
Recommended Name: Iron-responsive element-binding protein 2  
Size: 963 amino acids; 105045 Da
Cofactor: Binds 1 4Fe-4S cluster per subunit (By similarity). 4Fe-4S-binding affects RNA-binding activity, thereby
inhibiting activity of the protein (By similarity)
Subunit: Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions. Interacts (when associated with the
4Fe-4S) with FBXL5
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA79926.1; Type=Frameshift; Positions=605, 611; Sequence=BAD92640.1; Type=Frameshift;
Positions=727;
Secondary accessions: A8KAC7 Q13095 Q1HE21 Q59FQ7 Q9UF17

Explore the universe of human proteins at neXtProt for IREB2: NX_P48200

Post-translational modifications:

  • Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF
    • complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its
    RNA-binding activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48200

    • 4/5 DME Specific Peptides for IREB2 (P48200) (see all 5)
     GPKRPQD  ANYLASP  SIRVLLE  TTDHISPAG 

    IREB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004127.1  
    ENSEMBL proteins: 
     ENSP00000453172   ENSP00000453532   ENSP00000258886   ENSP00000453058   ENSP00000452938  
     ENSP00000454063   ENSP00000453863  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IREB2
    OriGene Protein Over-expression Lysate: IREB2
    OriGene Custom Protein Services for IREB2 
    GenScript Custom Purified and Recombinant Proteins Services for IREB2
    Novus Biologicals IREB2 Protein
    Novus Biologicals IREB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IREB2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS7983023
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--


    IREB2 for ontologies           About GeneDecksing



    IREB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IREB2
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): IREB2
    OriGene Custom Antibody Services for IREB2 
    GenScript Custom Superior Antibodies Services for IREB2
    Novus Biologicals IREB2 Antibodies
    Search for Antibodies for IREB2 at Abcam  
    Uscn Antibodies for IREB2
    ThermoFisher Antibody for IREB2

    Assay Products for IREB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IREB2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IREB2

    Protein Domains /
    Families
    for IREB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IREB2 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001030 Acoase/IPM_deHydtase_lsu_aba
     IPR018136 Aconitase_4Fe-4S_BS
     IPR000573 AconitaseA/IPMdHydase_ssu_swvl
     IPR015932 Aconitase/IPMdHydase_lsu_aba_2
     IPR015934 Aconitase/Fe_reg_prot_2/AcnD

    Graphical View of Domain Structure for InterPro Entry P48200

    ProtoNet protein and cluster: P48200

    1 Blocks protein family: IPB000573 Aconitate hydratase

    UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200
    Similarity: Belongs to the aconitase/IPM isomerase family


    Function
    for IREB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IREB2_HUMAN, P48200
    Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in
    the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA.
    Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to
    the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA

         Genatlas biochemistry entry for IREB2:
    iron responsive element binding protein 2,structurally related to aconitase

    Enzyme Number (IUBMB): EC 4.2.1.32

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IREB2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IREB2
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate IREB2 (see all 75):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4267 hsa-miR-490-5p hsa-miR-374b* hsa-miR-3065-5p hsa-miR-548o hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IREB2 (see all 7)
    OriGene shRNA RFP: IREB2
    OriGene siRNA: IREB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IREB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IREB2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IREB2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IREB2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IREB2 (NM_004136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IREB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IREB2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IREB2
    Search LifeMap BioReagents cell lines for IREB2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IREB2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9924025
    GO:0005515protein binding IPI19762596
    GO:0030350iron-responsive element binding TAS9924025
    GO:0046872metal ion binding IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--


    IREB2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IREB2:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for IREB2: Ireb2tm1Roua Ireb2tm1.2Mwh
         11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ireb2):
     behavior/neurological  digestive/alimentary  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  nervous system  normal 
     skeleton 

    IREB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IREB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1iron metabolism in placenta
    		iron metabolism in placenta1.00
    2Validated targets of C-MYC transcriptional activation
    		Validated targets of C-MYC transcriptional activation1.00


    2 BioSystems Pathways for IREB2 
        iron metabolism in placenta
    Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IREB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for IREB2 (P482003 ENSP000002588864) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBCK1Q9BYM83, ENSP000003486324I2D: score=2 STRING: ENSP00000348632
    FBXL5Q9UKA13, ENSP000003448664I2D: score=1 STRING: ENSP00000344866
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    YBX1P678093, ENSP000003616264I2D: score=3 STRING: ENSP00000361626
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0006782protoporphyrinogen IX biosynthetic process IEA--
    GO:0006826iron ion transport TAS9924025
    GO:0006879cellular iron ion homeostasis IEA--
    GO:0007568aging IEA--


    IREB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IREB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IREB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IREB2

    1 HMDB Compound for IREB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--
    10/24 Novoseek chemical compound relationships for IREB2 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 83.9 469 17822790 (10), 12972033 (9), 7665579 (8), 12888568 (7) (see all 99)
    iron-sulfur 72.3 1 11981450 (1)
    ferric ammonium citrate 69.3 4 16479012 (3)
    succinylacetone 59.5 2 12972033 (1), 16479012 (1)
    5-aminolevulinic acid 50.2 2 11741608 (1), 10522551 (1)
    n acetylcysteine 38.8 2 18073202 (1), 14729944 (1)
    cysteine 38.4 7 12972033 (2), 10484662 (1), 19223469 (1), 14729944 (1) (see all 5)
    citrate 37.3 1 17095152 (1)
    oxygen 35.5 11 12888568 (3), 11981450 (1), 10440237 (1), 12629548 (1) (see all 5)
    fe3+ 33 1 19454487 (1)

    Search CenterWatch for drugs/clinical trials and news about IREB2 

    Transcripts
    for IREB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IREB2 gene: 
    NM_004136.2  

    Unigene Cluster for IREB2:

    Iron-responsive element binding protein 2
    Hs.436031  [show with all ESTs]
    Unigene Representative Sequence: NM_004136
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560840 ENST00000559215 ENST00000258886(uc002bdr.2 uc010unb.1)
    ENST00000558525 ENST00000560440(uc002bdq.3) ENST00000558570 ENST00000560454
    ENST00000559427 ENST00000559676 ENST00000559091

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IREB2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IREB2
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate IREB2 (see all 75):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-4267 hsa-miR-490-5p hsa-miR-374b* hsa-miR-3065-5p hsa-miR-548o hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IREB2 (see all 7)
    OriGene shRNA RFP: IREB2
    OriGene siRNA: IREB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IREB2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IREB2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IREB2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IREB2 (NM_004136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IREB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IREB2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IREB2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IREB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IREB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IREB2

    Additional cDNA sequence: 

    AB209403.1 AB586699.1 AF147302.1 AK027033.1 AK027034.1 AK292992.1 AL117613.1 AL133439.1 
    BC017880.1 BC117481.1 BC117483.1 BC143948.1 M58511.1 U20180.1 

    14 DOTS entries:

    DT.212937  DT.312198  DT.203551  DT.91947945  DT.100706425  DT.121068179  DT.91976641  DT.100779763 
    DT.95316350  DT.95372714  DT.100688057  DT.100713326  DT.40245042  DT.95280843 

    24/230 AceView cDNA sequences (see all 230):

    AW150637 BX952058 AI435830 AI672118 AW615210 CN483934 AA344229 BX340905 
    AW841838 CR610815 NM_004136 W04901 AI499408 AF147302 AA406258 BM754995 
    BM698206 BM971831 N73405 BG258171 N66042 BQ285897 AI570117 CR593632 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IREB2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
    SP1:              -                                         -                 -                                                                                 
    SP2:              -                                         -                                                                                                   
    SP3:              -                                                                                                                                             
    SP4:                                                                                                                                                            
    SP5:        -     -                                                                                                                                             

    ExUns: 24a · 24b ^ 25
    SP1:        -         
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for IREB2

    Expression
    for IREB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IREB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGACATTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IREB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IREB2

    SOURCE GeneReport for Unigene cluster: Hs.436031
        SABiosciences Custom PCR Arrays for IREB2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IREB2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IREB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IREB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IREB2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IREB2

    Orthologs
    for IREB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for IREB2 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ireb21 , 5 iron responsive element binding protein 21, 5 91.36(n)1
    93.96(a)1    		   9 (29.81 cM)5
    646021  NM_022655.31  NP_073146.21 
     548637555 
    chicken
    (Gallus gallus)    		 Aves IREB21 iron-responsive element binding protein 2 77.55(n)
    82.43(a)    		   427490  NM_001031454.1  NP_001026625.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX704259.12   -- 72.58(n)    BX704259.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ireb21 iron-responsive element binding protein 2 64.05(n)
    68.71(a)    		   652982  XM_001341755.4  XP_001341791.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Irp-1B6
    Irp-1A6
    		 Iron regulatory protein 1A
    		 57(a)
    56(a)
    		 many ↔ many
    many ↔ many
    		 3R(6234337-6238638)
    3R(18547042-18550325)
    worm
    (Caenorhabditis elegans)    		 Secernentea aco-16
    		 Probable cytoplasmic aconitate hydratase
    		 56(a)
    		 1 → many
    		 X(11339808-11343504)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ACO16
    ACO26
    (see all 3)    		 aconitase 2
    (see all 3)    		 52(a)
    47(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 4(16972598-16978057)
    4(13542918-13548629)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 aconitate hydratase protein, putative, expressed
    (see all 3)    		 48(a)
    47(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 3(2025673-2032637)
    8(5326534-5333954)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria acnA6
    ybhJ6
    		 predicted hydratase
    		 45(a)
    17(a)
    		 many → 1
    possible ortholog
    		 Chromosome(1333855-1336530)
    Chromosome(802726-804987)


    ENSEMBL Gene Tree for IREB2 (if available)
    TreeFam Gene Tree for IREB2 (if available) 

    Paralogs
    for IREB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IREB2 gene
    ACO22  ACO12  
    4 SIMAP similar genes for IREB2 using alignment to 9 protein entries:     IREB2_HUMAN (see all proteins):
    IREB2 variant    DKFZp686P10119    ACO1    IRP1

    IREB2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IREB2
    PGOHUM00000239338 PGOHUM00000239343


    Genomic Variants
    for IREB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1141 NCBI SNPs in IREB2 are shown (see all 1141)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs21022641,2
    		C,F,A,--78728608(+) cctgcA/Ggcttt 1 -- us2k1 tfbs37Minor allele frequency- G:0.35NA WA CSA 130
    rs1869848481,2
    		--78728629(+) AGTGCC/TGGGAT 1 -- us2k10--------
    rs1391983811,2
    		--78728713(+) ATAAAC/TAGATA 1 -- us2k10--------
    rs789395641,2
    		C,F,--78728723(+) ACAAGC/TATCTG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs788682131,2
    		C,--78728939(+) TGAATA/GAAGGA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1919056411,2
    		--78729105(+) AGGAGA/GGAAAT 1 -- us2k10--------
    rs1493613151,2
    		--78729110(+) GGAAAC/TGACGA 1 -- us2k10--------
    rs1446832461,2
    		--78729194(+) CTCCGA/GGTTTA 1 -- us2k10--------
    rs775769491,2
    		C,F,--78729243(+) AACATA/GTTAAC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1394641941,2
    		--78729549(+) CGTTGC/TTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IREB2 (78729773 - 78793798 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IREB2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IREB2
    DNA2.0 Custom Variant and Variant Library Synthesis for IREB2

    Disorders / Diseases
    for IREB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IREB2 for disorders           About GeneDecksing

    OMIM gene information: 147582    OMIM disorders: --

    20/32 diseases for IREB2 (see all 32):    About MalaCards
    hallervorden-spatz syndrome    erythropoietic protoporphyria    iron deficiency anemia    iron overload
    restless legs syndrome    microcytic anemia    beta thalassemia    sideroblastic anemia
    friedreich ataxia    hemochromatosis    sickle cell disease    anemia
    neurodegenerative disease    thalassemia    parkinson's disease    alzheimer's disease
    neurodegeneration    acne    copd    duodenitis

    1 disease from the University of Copenhagen DISEASES database for IREB2:
    Hallervorden-Spatz syndrome

    10 Novoseek disease relationships for IREB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron overload 63.7 2 12691842 (1), 20364084 (1)
    iron deficiency 62.8 10 18549630 (1), 8668195 (1), 18574241 (1), 15684386 (1)
    hereditary hemochromatosis 45.6 1 16503547 (1)
    neurodegenerative diseases 40.2 5 16850017 (1), 12691842 (1), 11175792 (1)
    parkinson disease 29.5 6 12465072 (3), 15057521 (1)
    iron deficiency anemia 23.4 1 16503547 (1)
    neurodegeneration 20.7 4 15831703 (2), 12691842 (1)
    anemia 10.4 1 16850017 (1)
    cancer lung 0 1 20405006 (1), 15684386 (1), 17760563 (1)
    alzheimers disease 0 2 16914832 (1), 17408857 (1)

    Genetic Association Database (GAD): IREB2
    Human Genome Epidemiology (HuGE) Navigator: IREB2 (9 documents)

    Export disorders for IREB2 gene to outside databases

    Publications
    for IREB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IREB2 gene, integrated from 9 sources (see all 160):
    (articles sorted by number of sources associating them with IREB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein. (PubMed id 2172968)1, 2, 3 Rouault T.A.... Klausner R.D. (1990)
    2. Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. (PubMed id 7622457)1, 2, 9 Guo B.... Leibold E.A. (1995)
    3. Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. (PubMed id 12629548)1, 2, 9 Yamanaka K.... Iwai K. (2003)
    4. Polymorphisms in iron-responsive binding protein 2 and lack of association with sporadic Parkinson's disease. (PubMed id 12465072)1, 4, 9 Lee P.L....Beutler E. (2002)
    5. Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation. (PubMed id 7983023)1, 2, 9 Samaniego F.... Klausner R.D. (1994)
    6. Control of iron homeostasis by an iron-regulated ubiquitin ligase. (PubMed id 19762596)1, 2, 9 Vashisht A.A.... Wohlschlegel J.A. (2009)
    7. An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. (PubMed id 19762597)1, 2, 9 Salahudeen A.A.... Bruick R.K. (2009)
    8. HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells. (PubMed id 17822790)1, 9 Zumbrennen K.B....Leibold E.A. (2008)
    9. Oxygen and iron regulation of iron regulatory protein 2. (PubMed id 12888568)1, 9 Hanson E.S....Leibold E.A. (2003)
    10. Tumorigenic properties of iron regulatory protein 2 ( IRP2) mediated by its specific 73-amino acids insert. (PubMed id 20405006)1, 9 Maffettone C....Pantopoulos K. (2010)

    External Searches for IREB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IREB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3658 HGNC: 6115 AceView: IREB2 Ensembl:ENSG00000136381 euGenes: HUgn3658
    ECgene: IREB2 H-InvDB: IREB2

    Other Databases showing IREB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IREB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IREB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IREB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IREB2 gene:
    Search GeneIP for patents involving IREB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IREB2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IREB2
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for IREB2   OriGene shRNA RFP for IREB2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IREB2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IREB2  
     OriGene Protein Over-expression Lysate for IREB2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IREB2   OriGene 3'-UTR Clone for IREB2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IREB2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IREB2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for IREB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IREB2   OriGene Custom Protein Services for IREB2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IREB2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IREB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IREB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IREB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IREB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IREB2
     GenScript Custom Purified and Recombinant Proteins Services for IREB2 GenScript cDNA clones with any tag delivered in your preferred vector for IREB2
     GenScript Custom Assay Services for IREB2 GenScript Custom Superior Antibodies Services for IREB2
     GenScript Custom overexpressing Cell Line Services for IREB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IREB2 promoter
     Search Chromatin IP Primers for IREB2
     RT2 qPCR Primer Assay in human, mouse, rat IREB2
     GNC Network for IREB2
     SABiosciences Custom PCR Arrays for IREB2
     Search Tocris compounds for IREB2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IREB2 antibodies
     IREB2 proteins
     IREB2 lysates
     Search for Antibodies for IREB2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for IREB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     IREB2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IREB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IREB2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IREB2
     SwitchGear Promoter luciferase reporter plasmids for IREB2
     ThermoFisher Antibody for IREB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IREB2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IREB2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4