Aliases for IREB2 Gene
External Ids for IREB2 Gene
Previous GeneCards Identifiers for IREB2 Gene
GeneCards Summary for IREB2 Gene
IREB2 (Iron-Responsive Element Binding Protein 2) is a Protein Coding gene. Diseases associated with IREB2 include hyperferritinemia-cataract syndrome. Among its related pathways are Validated targets of C-MYC transcriptional activation and Iron metabolism in placenta. GO annotations related to this gene include RNA binding and iron-responsive element binding. An important paralog of this gene is ACO1.
UniProtKB/Swiss-Prot for IREB2 Gene
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.