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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IRAK3 Gene

protein-coding GIFtS: 63
GCID: GC12P066582

interleukin-1 receptor-associated kinase 3

Explore 20 diseases affiliated with
IRAK3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin-1 Receptor-Associated Kinase 3¹ ²		IRAKM² ⁵
IRAK-M¹ ³		EC 2.7.11.1³
IL-1 Receptor-Associated Kinase M² ³		IRAK-3³
ASRT5² ⁵

External Ids:	HGNC: 17020¹	Entrez Gene: 11213²	Ensembl: ENSG00000090376⁷	OMIM: 604459⁵	UniProtKB: Q9Y616³

Export aliases for IRAK3 gene to outside databases

Previous GC identifers: GC12P065974 GC12P066443 GC12P066299 GC12P064869 GC12P063633

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRAK3:

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are

essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in

monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this

gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.

(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616

Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting

the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity)

Gene Wiki entry for IRAK3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IRAK3 gene promoter:
AP-1 ATF-2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) Nkx2-5 POU3F2 PPAR-gamma1 PPAR-gamma2 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRAK3 promoter sequence

Search SABiosciences Chromatin IP Primers for IRAK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3 Ensembl cytogenetic band: 12q14.3 HGNC cytogenetic band: 12q13.13

IRAK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK3 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P066582: view genomic region (about GC identifiers)

Start:	66,582,659 bp from pter	End:	66,648,402 bp from pter
Size:	65,744 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616 (See protein sequence)

Recommended Name: Interleukin-1 receptor-associated kinase 3

Size: 596 amino acids; 67767 Da

Cofactor: Magnesium

Caution: Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level

autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an inactive

kinase

Secondary accessions: B4DQ57

Alternative splicing: 2 isoforms: Q9Y616-1 Q9Y616-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IRAK3: NX_Q9Y616

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y616

IRAK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001135995.1 NP_009130.2

ENSEMBL proteins:

ENSP00000261233 ENSP00000441321 ENSP00000409852

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IRAK3 OriGene Protein Over-expression Lysate (see all 2): IRAK3 OriGene Custom Protein Services for IRAK3
	GenScript Custom Purified and Recombinant Proteins Services for IRAK3
	Novus Biologicals IRAK3 Proteins Novus Biologicals IRAK3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IRAK3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17379480
GO:0005737	cytoplasm	IDA	17379480

IRAK3 for ontologies About GeneDecksing

IRAK3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IRAK3
	R&D Systems Antibodies for IRAK3
	Cell Signaling Technology (CST) Antibodies for IRAK3
	OriGene Antibodies (see all 4): IRAK3 OriGene Custom Antibody Services for IRAK3
	GenScript Custom Superior Antibodies Services for IRAK3
	Novus Biologicals IRAK3 Antibodies
	Abcam antibodies for IRAK3
	Uscn Antibodies for IRAK3
	ThermoFisher Antibody for IRAK3

Assay Products for IRAK3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IRAK3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IRAK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IRAK3 for domains About GeneDecksing

4 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR011009 Kinase-like_dom

IPR000488 Death_domain

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q9Y616

ProtoNet protein and cluster: Q9Y616

1 Blocks protein family: IPB000488 Death domain

UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily

Similarity: Contains 1 death domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616

Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting

the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1¹

miRNA Products:		miRTarBase miRNAs that target IRAK3: hsa-mir-155 (MIRT005808)

		OriGene 3'-UTR Clone (see all 2): IRAK3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK3
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK3 (see all 26):
		hsa-miR-320a hsa-miR-3685 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-3942-5p hsa-miR-522 hsa-miR-340

		SwitchGear 3'UTR luciferase reporter plasmid: IRAK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK3 (see all 7) OriGene shRNA RFP: IRAK3 OriGene siRNA: IRAK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IRAK3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IRAK3 (NM_001142523)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IRAK3
		Search LifeMap BioReagents cell lines for IRAK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK3

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	10383454
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IDA	10383454
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IDA	10383454

IRAK3 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for IRAK3:

Decreased focal adhesion (FA)	Increased gamma-H2AX phosphory	Increased mitotic index	Increases Tamoxifen sensitivit
Synthetic lethal with Ras	Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Irak3^tm1Flv for IRAK3
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Irak3):

growth/size

hematopoietic system

immune system

limbs/digits/tail

skeleton

IRAK3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Toll Comparative Pathway

	Toll Comparative Pathway	1.00			IL-1 Pathway	0.39
	TLR-TRIF Pathway	0.61			iNOS Signaling	0.34

Transcription NF-kB signaling pathway

Transcription NF-kB signaling pathway

1.00

Transcription_NF-kB signaling pathway

0.85

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

1.00

Immune response_TLR signaling pathways

0.94

TRAF Pathway

TRAF Pathway

1.00

Toll-Like Receptors Pathway

0.41

14-3-3 Induced Apoptosis

14-3-3 Induced Apoptosis

1.00

Apoptosis

0.37

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IRAK3

	Transcription NF-kB signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRAK3 (see all 12)

	MAPK Signaling
	14-3-3 Induced Apoptosis
	NF-KappaB (p50-p65) Pathway
	Toll-Like Receptors Pathway
	TRAF Pathway

2 Cell Signaling Technology (CST) Pathways for IRAK3

	Lymphocyte Signaling
	NF-kappaB Signaling

2 GeneGo (Thomson Reuters) Pathways for IRAK3

	Transcription NF-kB signaling pathway
	Immune response TLR signaling pathways

1 BioSystems Pathway for IRAK3

IL1-mediated signaling events

2 Kegg Pathways (Kegg details for IRAK3):

	Apoptosis
	Neurotrophin signaling pathway

IRAK3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IRAK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for IRAK3 (Q9Y616^{1, 2, 3} ENSP00000261233⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IRAK1	P51617¹^,²^,³, ENSP00000358997⁴	EBI-447690,EBI-358664 MINT-50488 I2D: score=6 STRING: ENSP00000358997
IRAK2	O43187¹^,²^,³, ENSP00000256458⁴	EBI-447690,EBI-447733 MINT-50489 I2D: score=4 STRING: ENSP00000256458
TRAF6	Q9Y4K3²^,³	MINT-50486 I2D: score=8
MYD88	Q99836²^,³, ENSP00000379625⁴	MINT-50483 I2D: score=6 STRING: ENSP00000379625
TICAM2	Q86XR7³, ENSP00000386341⁴	I2D: score=2 STRING: ENSP00000386341

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001960	negative regulation of cytokine-mediated signaling pathway	IC	12150927
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	10383454
GO:0006468	protein phosphorylation	IDA	10383454
GO:0009615	response to virus	IC	12150927
GO:0010933	positive regulation of macrophage tolerance induction	ISS	12150927

IRAK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IRAK3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IRAK3

3 HMDB Compounds for IRAK3 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 Novoseek chemical compound relationship for IRAK3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
endotoxin	52.8	5	19414798 (2), 17621545 (2), 16645484 (1)

Search CenterWatch for drugs/clinical trials and news about IRAK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IRAK3 gene (2 alternative transcripts):

NM_001142523.1 NM_007199.2

Unigene Cluster for IRAK3:

Interleukin-1 receptor-associated kinase 3

Hs.369265 [show with all ESTs]

Unigene Representative Sequence: NM_007199

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261233(uc001sth.3 uc010ssy.2) ENST00000545837(uc001stg.2)

ENST00000457197

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IRAK3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK3
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK3 (see all 26):
		hsa-miR-320a hsa-miR-3685 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-3942-5p hsa-miR-522 hsa-miR-340

		SwitchGear 3'UTR luciferase reporter plasmid: IRAK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK3 (see all 7) OriGene shRNA RFP: IRAK3 OriGene siRNA: IRAK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IRAK3 (NM_001142523)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IRAK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK3

Additional cDNA sequence:

AF113136.1 AK023663.1 AK298645.1 AK314040.1 AL049435.1 BC029493.1 BC047399.1 BC057800.1

BC069388.1

5 DOTS entries:

DT.309189 DT.104007 DT.95358096 DT.121151723 DT.95361022

24/28 AceView cDNA sequences (see all 28):

BF933311 BF893341 BF933310 AA885124 BM982153 AF113136 BC057800 BM989160

BQ009433 NM_007199 BC047399 BU657740 AW572076 AL601662 AW268584 BC069388

BM984196 AL599569 BC029493 BI461677 CB997254 CB994069 AW864372 BI462295

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IRAK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTTTGAA

About this image

IRAK3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Early limb mesenchymal cells (ELM cells) (Primary Cell)

Bone, Cartilage, Limb

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See IRAK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRAK3

SOURCE GeneReport for Unigene cluster: Hs.369265

UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616

Tissue specificity: Expressed predominantly in peripheral blood lymphocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including IRAK3:

T-Cell Anergy & Immune Tolerance in human mouse rat

Antibacterial Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IRAK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRAK3 gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Irak3^{1 , 5}	interleukin-1 receptor-associated kinase 3^{1, 5}	79.64(n)¹ 76.17(a)¹		10 (67.94 cM)⁵ 73914¹ NM_028679.3¹ NP_082955.2¹ 120141648⁵
zebrafish (Danio rerio)	Actinopterygii	irak3¹	interleukin-1 receptor-associated kinase 3	52.39(n) 43.57(a)		567444 XM_003198259.1 XP_003198307.1
fruit fly (Drosophila melanogaster)	Insecta	pll⁶	pelle	22(a)	1 → many	3R(23076853-23078902)
worm (Caenorhabditis elegans)	Secernentea	pik-1⁶	Pelle/IL-1 receptor associated Kinase (IRAK) famil...	22(a)	1 → many	IV(13416768-13421501)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G56890⁶ AT3G20530⁶ (see all 38)	protein kinase family protein (see all 38)	9(a) 25(a) (see all 38)	many ↔ many many ↔ many (see all 38)	5(23010523-23015671) 3(7166047-7167929)
rice (Oryza sativa)	Liliopsida	-- -- (see all 35)	protein kinase, putative, expressed protein kinase APK1B, chloroplast precursor, putat... (see all 35)	25(a) 23(a) (see all 35)	many ↔ many many ↔ many (see all 35)	2(35815817-35817104) 7(29629568-29632475)

ENSEMBL Gene Tree for IRAK3 (if available)
TreeFam Gene Tree for IRAK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IRAK3 gene

IRAK1² IRAK4² IRAK2²

IRAK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1797401^1,2	C,F,	--	63632316(-)	`ATCACG/AAGTGA`	2	--	us2k¹		4	NA EU WA	212
rs11176083^1,2	C,F,	--	63632594(+)	`CACTTT/CGAGGA`	2	--	us2k¹		4	NA EU WA	212
rs74809457^1,2		--	63632742(+)	`TGTTTT/CTCTCT`	2	--	us2k¹		1	EA	120
rs11834885^1,2	C,F,H,	--	63633349(+)	`TGACAC/ACGCTA`	2	--	us2k¹		5	NS NA	696
rs78548067^1,2	C,F,	--	63634199(+)	`TTCTGG/CTCCTT`	2	--	int¹		3	NA	124
rs11465938^1,2	C,F,	--	63634216(+)	`TCACCC/TCAGAA`	2	--	int¹		4	NA EU WA	212
rs11465939^1,2	C,F,	--	63634389(+)	`CCAATT/GTCGTT`	2	--	int¹		7	NA EU WA	336
rs11465940^1,2	C,	--	63634458(+)	`GAACTG/ATATTT`	2	--	int¹		4	NA EU	214
rs78141714^1,2	F,	--	63634528(+)	`TAATTC/TGGACA`	2	--	int¹		1	EA	120
rs11465941^1,2	C,F,	--	63634536(+)	`ACAAAA/GATCTT`	2	--	int¹		4	NA EU WA	210

HapMap Linkage Disequilibrium report for IRAK3 (66582659 - 66648402 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IRAK3
2 Indels: 60095 66253
Human Gene Mutation Database (HGMD): IRAK3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRAK3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IRAK3 for disorders           About GeneDecksing

OMIM gene information: 604459
OMIM disorders: 611064
UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616

Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064].

Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial

hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis

20 diseases for IRAK3: About MalaCards

asthma asthma susceptibility 5 inflammatory bowel disease melioidosis

atopic dermatitis dermatitis periodontitis hepatitis c

periodontal disease atopy sepsis hepatitis b

rabies pertussis gingivitis meningioma

hepatitis breast cancer leukemia alcoholism

4 Novoseek disease relationships for IRAK3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sepsis	34.6	12	16917541 (3), 16645484 (1), 18786322 (1)
inflammation	29.7	2	19013233 (1)
necrosis	27.8	9	14729660 (1), 16645484 (1), 18786322 (1)
tumors	7.88	10	16645484 (2), 14729660 (1), 18786322 (1)

Human Genome Epidemiology (HuGE) Navigator: IRAK3 (24 documents)

Export disorders for IRAK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IRAK3 gene, integrated from 9 sources (see all 70):
(articles sorted by number of sources associating them with IRAK3)

Utopia: connect your pdf to the dynamic
world of online information

IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PubMed id 10383454)^{1, 2, 3} Wesche H.... Cao Z. (1999)
IRAK-M is involved in the pathogenesis of early-onset persistent asthma. (PubMed id 17503328)^{1, 2} Balaci L.... Pilia G. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression. (PubMed id 19414798)^{1, 9} Zacharioudaki V....Tsatsanis C. (2009)
Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases. (PubMed id 17558906)^{1, 9} Weersma R.K....Dijkstra G. (2007)
Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides. (PubMed id 18354163)^{1, 9} Shen W....Ladisch S. (2008)
Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)^{1, 9} Kimman T.G....Kerkhof M. (2008)
No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort. (PubMed id 19013233)^{1, 9} Beygo J....Hoffjan S. (2008)
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PubMed id 12721283)^{1, 9} Bin L.H.... Shu H.B. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11213	HGNC: 17020	AceView: IRAK3	Ensembl:ENSG00000090376	euGenes: HUgn11213
ECgene: IRAK3	Kegg: 11213	H-InvDB: IRAK3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IRAK3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IRAK3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IRAK3 gene:
Search GeneIP for patents involving IRAK3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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interleukin-1 receptor-associated kinase 3

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interleukin-1 receptor-associated kinase 3

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