Aliases for IRAK3 Gene
External Ids for IRAK3 Gene
Previous GeneCards Identifiers for IRAK3 Gene
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for IRAK3 Gene
IRAK3 (Interleukin-1 Receptor-Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include asthma susceptibility 5 and melioidosis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include protein homodimerization activity and protein serine/threonine kinase activity. An important paralog of this gene is IRAK4.
UniProtKB/Swiss-Prot for IRAK3 Gene
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.