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IRAK3 Gene

protein-coding   GIFtS: 65
GCID: GC12P066582

Interleukin-1 Receptor-Associated Kinase 3

  See IRAK3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin-1 Receptor-Associated Kinase 31 2     EC 2.7.11.13
IL-1 Receptor-Associated Kinase M2 3     IRAK-33
ASRT52 5     IRAK-M3
IRAKM2 5     

External Ids:    HGNC: 170201   Entrez Gene: 112132   Ensembl: ENSG000000903767   OMIM: 6044595   UniProtKB: Q9Y6163   

Export aliases for IRAK3 gene to outside databases

Previous GC identifers: GC12P065974 GC12P066443 GC12P066299 GC12P064869 GC12P063633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRAK3 Gene:
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family
are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily
expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling.
Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple
transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for IRAK3 Gene:
IRAK3 (interleukin-1 receptor-associated kinase 3) is a protein-coding gene. Diseases associated with IRAK3 include asthma susceptibility 5, and melioidosis. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is IRAK1.

UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616
Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either
inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity)

Gene Wiki entry for IRAK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRAK3 gene promoter:
         AP-1   ATF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   POU3F2   PPAR-gamma1   PPAR-gamma2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRAK3 promoter sequence
   Search Chromatin IP Primers for IRAK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRAK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q13.13

IRAK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P066582:  view genomic region     (about GC identifiers)

Start:
66,582,659 bp from pter      End:
66,648,402 bp from pter
Size:
65,744 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616 (See protein sequence)
Recommended Name: Interleukin-1 receptor-associated kinase 3  
Size: 596 amino acids; 67767 Da
Cofactor: Magnesium
Caution: Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level
autophosphorylation activity has been reported in PubMed:10383454, while other authors describe this as an
inactive kinase
Secondary accessions: B4DQ57
Alternative splicing: 2 isoforms:  Q9Y616-1   Q9Y616-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IRAK3: NX_Q9Y616

Explore proteomics data for IRAK3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys379
  • Modification sites at PhosphoSitePlus

  • See IRAK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135995.1  NP_009130.2  

    ENSEMBL proteins: 
     ENSP00000261233   ENSP00000441321   ENSP00000409852  
    Reactome Protein details: Q9Y616

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    Novus Biologicals IRAK3 Proteins
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    IRAK3 Antibody Products:

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    IRAK3 Assay Products:

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    Search eBioscience for ELISAs for IRAK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: interleukin-1 receptor-associated kinase 3
    Interleukin-1 receptor-associated kinase (IRAK) family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry Q9Y616

    ProtoNet protein and cluster: Q9Y616

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with IRAK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRAK3_HUMAN, Q9Y616
    Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either
    inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10383454
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10383454
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IRAK3           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for IRAK3:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory  Increased mitotic index  Increases Tamoxifen sensitivit 
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irak3):
     growth/size/body  hematopoietic system  immune system  limbs/digits/tail  skeleton 

    Find genes that share phenotypes with IRAK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Irak3tm1Flv for IRAK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRAK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRAK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRAK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRAK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRAK3:
    hsa-mir-124-3p (MIRT023129), hsa-mir-16-5p (MIRT051159), hsa-mir-155-3p (MIRT005808)

    Block miRNA regulation of human, mouse, rat IRAK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRAK3 (see all 26):
    hsa-miR-320a hsa-miR-3685 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-3942-5p hsa-miR-522 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidIRAK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRAK3
    Predesigned siRNA for gene silencing in human, mouse, rat IRAK3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): IRAK3 (NM_001142523)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK3
    Addgene plasmids for IRAK3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17379480
    GO:0005737cytoplasm IDA17379480

    Find genes that share ontologies with IRAK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRAK3 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL1-mediated signaling events0.45
    2Apoptosis (KEGG)
    14-3-3 Induced Apoptosis0.37
    Apoptosis0.37
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    4NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    5TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41


    Find genes that share SuperPaths with IRAK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IRAK3 (see all 12)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway

    2 Cell Signaling Technology (CST) Pathways for IRAK3
        Lymphocyte Signaling
    NF-kappaB Signaling

    2 GeneGo (Thomson Reuters) Pathways for IRAK3
        Transcription NF-kB signaling pathway
    Immune response TLR signaling pathways

    1 BioSystems Pathway for IRAK3
        IL1-mediated signaling events

    2 Reactome Pathways for IRAK3
        Interleukin-1 signaling
    MyD88:Mal cascade initiated on plasma membrane


    2 Kegg Pathways  (Kegg details for IRAK3):
        Apoptosis
    Neurotrophin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRAK3: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRAK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRAK3 (Q9Y6162, 3 ENSP000002612334) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516172, 3, ENSP000003589974MINT-50488 I2D: score=6 STRING: ENSP00000358997
    IRAK2O431872, 3, ENSP000002564584MINT-50489 I2D: score=4 STRING: ENSP00000256458
    TRAF6Q9Y4K32, 3MINT-50486 I2D: score=8 
    MYD88Q998362, 3, ENSP000003796254MINT-50483 I2D: score=6 STRING: ENSP00000379625
    TICAM2Q86XR73, ENSP000003863414I2D: score=2 STRING: ENSP00000386341
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001960negative regulation of cytokine-mediated signaling pathway IC12150927
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS10383454
    GO:0006468protein phosphorylation IDA10383454
    GO:0007165signal transduction ----
    GO:0009615response to virus IC12150927

    Find genes that share ontologies with IRAK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRAK3

    3 HMDB Compounds for IRAK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 Novoseek inferred chemical compound relationship for IRAK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 52.8 5 19414798 (2), 17621545 (2), 16645484 (1)



    Find genes that share compounds with IRAK3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRAK3 gene (2 alternative transcripts): 
    NM_001142523.1  NM_007199.2  

    Unigene Cluster for IRAK3:

    Interleukin-1 receptor-associated kinase 3
    Hs.369265  [show with all ESTs]
    Unigene Representative Sequence: NM_007199
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261233(uc001sth.3 uc010ssy.2) ENST00000545837(uc001stg.2)
    ENST00000457197
    miRNA
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    hsa-miR-320a hsa-miR-3685 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-3942-5p hsa-miR-522 hsa-miR-340
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    Addgene plasmids for IRAK3 
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    Additional mRNA sequence: 

    AF113136.1 AK023663.1 AK298645.1 AK314040.1 AL049435.1 BC029493.1 BC047399.1 BC057800.1 
    BC069388.1 

    5 DOTS entries:

    DT.309189  DT.104007  DT.95358096  DT.121151723  DT.95361022 

    Selected AceView cDNA sequences (see all 28):

    BF933310 BF933311 AA885124 BF893341 BM982153 NM_007199 BQ009433 BM989160 
    AF113136 BC057800 AW572076 AW268584 BC047399 BU657740 AL601662 BC069388 
    BM984196 AL599569 BC029493 CB994069 BI461677 CB997254 AW864372 BI462295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRAK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTTTGAA
    IRAK3 Expression
    About this image


    IRAK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    IRAK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRAK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369265

    UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616
    Tissue specificity: Expressed predominantly in peripheral blood lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRAK3: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IRAK3
    OriGene qSTAR qPCR primer pairs in human, mouse for IRAK3
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    QuantiFast Probe-based Assays in human, mouse, rat IRAK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IRAK3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irak31 , 5 interleukin-1 receptor-associated kinase 31, 5 79.64(n)1
    76.17(a)1
      10 (67.94 cM)5
    739141  NM_028679.31  NP_082955.21 
     1201416485 
    zebrafish
    (Danio rerio)
    Actinopterygii irak31 interleukin-1 receptor-associated kinase 3 54.54(n)
    47.71(a)
      567444  XM_003198259.2  XP_003198307.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta pll6
    pelle
    24(a)
    1 → many
    3R(23076853-23078902)
    worm
    (Caenorhabditis elegans)
    Secernentea pik-16
    Protein PIK-1, isoform b (pik-1) mRNA, complete cd...
    23(a)
    1 → many
    IV(13416041-13421525) WBGene00004029


    ENSEMBL Gene Tree for IRAK3 (if available)
    TreeFam Gene Tree for IRAK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRAK3 gene
    IRAK12  IRAK42  IRAK22  

    Find genes that share paralogs with IRAK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRAK3 (see all 1384)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402446141,2
    --63632145(+) GGAAGA/GTAGGT 2 -- us2k10--------
    rs731253671,2
    C--63649214(+) TGCGCG/ACACAC 2 -- int11Minor allele frequency- A:0.00NA 2
    rs2008041721,2
    C--63649222(+) CACACA/GCACAC 2 -- int10--------
    rs114053521,2
    C--63656545(+) AAAAAA/-GACTT 2 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4
    rs1115104101,2
    C,F--63668126(+) CTCCGT/ACTCAA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs3747091051,2
    C--63690215(+) TGGCA-/CTATCT
            
    CGGCC
    4 -- int1 cds10--------
    rs1116840771,2
    C--63691886(+) ATCTC-/A/CAAAAA 2 -- int11CSA 2
    rs1385036531,2
    --66418479(+) TGCCTC/TCCTGT 2 -- us2k10--------
    rs1838116291,2
    --66418500(+) CAAAAA/GCTACC 2 -- us2k10--------
    rs1883425671,2
    --66418579(+) GGGCCA/GGGTGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for IRAK3 (66582659 - 66648402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IRAK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899215CNV Loss21882294
    esv29230CNV Loss19812545
    nsv899216CNV Gain21882294
    esv7862CNV Gain19470904

    Human Gene Mutation Database (HGMD): IRAK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRAK3
    DNA2.0 Custom Variant and Variant Library Synthesis for IRAK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604459   
    OMIM disorders: 611064  
    UniProtKB/Swiss-Prot: IRAK3_HUMAN, Q9Y616
  • Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma,
    such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test,
    serum IgE levels, atopy and atopic dermatitis. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry

  • 3 diseases for IRAK3:    
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    asthma susceptibility 5    melioidosis    asthma


    Find genes that share disorders with IRAK3           About GenesLikeMe

    4 Novoseek inferred disease relationships for IRAK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sepsis 34.6 12 16917541 (3), 16645484 (1), 18786322 (1)
    inflammation 29.7 2 19013233 (1)
    necrosis 27.8 9 14729660 (1), 16645484 (1), 18786322 (1)
    tumors 7.88 10 16645484 (2), 14729660 (1), 18786322 (1)

    Genetic Association Database (GAD): IRAK3
    Human Genome Epidemiology (HuGE) Navigator: IRAK3 (24 documents)

    Export disorders for IRAK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRAK3 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with IRAK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. (PubMed id 17503328)1, 2, 4 Balaci L.... Pilia G. (Am. J. Hum. Genet. 2007)
    2. IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PubMed id 10383454)1, 2, 3 Wesche H.... Cao Z. (J. Biol. Chem. 1999)
    3. Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases. (PubMed id 17558906)1, 4, 9 Weersma R.K....Dijkstra G. (Scand. J. Gastroenterol. 2007)
    4. No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort. (PubMed id 19013233)1, 4, 9 Beygo J....Hoffjan S. (Mol. Cell. Probes 2009)
    5. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4, 9 Kimman T.G....Kerkhof M. (PLoS ONE 2008)
    6. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. (PubMed id 20448286)1, 4 Potter C....Isaacs J.D. (Ann. Rheum. Dis. 2010)
    7. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    8. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    9. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11213 HGNC: 17020 AceView: IRAK3 Ensembl:ENSG00000090376 euGenes: HUgn11213
    ECgene: IRAK3 Kegg: 11213 H-InvDB: IRAK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRAK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IRAK3 gene:
    Search GeneIP for patents involving IRAK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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