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Aliases for IRAK3 Gene

Aliases for IRAK3 Gene

  • Interleukin-1 Receptor-Associated Kinase 3 2 3
  • IL-1 Receptor-Associated Kinase M 3 4
  • ASRT5 3 6
  • IRAKM 3 6
  • EC 2.7.11.1 4
  • IRAK-3 4
  • IRAK-M 4

External Ids for IRAK3 Gene

Previous GeneCards Identifiers for IRAK3 Gene

  • GC12P065974
  • GC12P066443
  • GC12P066299
  • GC12P064869
  • GC12P066582
  • GC12P063633

Summaries for IRAK3 Gene

Entrez Gene Summary for IRAK3 Gene

  • This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for IRAK3 Gene

IRAK3 (Interleukin-1 Receptor-Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include asthma susceptibility 5 and melioidosis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include protein homodimerization activity and protein serine/threonine kinase activity. An important paralog of this gene is IRAK4.

UniProtKB/Swiss-Prot for IRAK3 Gene

  • Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Gene Wiki entry for IRAK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK3 Gene

Genomics for IRAK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRAK3 Gene

Start:
66,188,879 bp from pter
End:
66,254,622 bp from pter
Size:
65,744 bases
Orientation:
Plus strand

Genomic View for IRAK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRAK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK3 Gene

Proteins for IRAK3 Gene

  • Protein details for IRAK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y616-IRAK3_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase 3
    Protein Accession:
    Q9Y616
    Secondary Accessions:
    • B4DQ57

    Protein attributes for IRAK3 Gene

    Size:
    596 amino acids
    Molecular mass:
    67767 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IRAK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRAK3 Gene

Proteomics data for IRAK3 Gene at MOPED

Post-translational modifications for IRAK3 Gene

  • Ubiquitination at Lys379
  • Modification sites at PhosphoSitePlus

Other Protein References for IRAK3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRAK3 (IRAK3)

No data available for DME Specific Peptides for IRAK3 Gene

Domains for IRAK3 Gene

Protein Domains for IRAK3 Gene

Suggested Antigen Peptide Sequences for IRAK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y616

UniProtKB/Swiss-Prot:

IRAK3_HUMAN :
  • Q9Y616
Domain:
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK3: view

Function for IRAK3 Gene

Molecular function for IRAK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Enzyme Numbers (IUBMB) for IRAK3 Gene

Gene Ontology (GO) - Molecular Function for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10383454
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10383454
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IRAK3: view
genes like me logo Genes that share phenotypes with IRAK3: view

Animal Models for IRAK3 Gene

MGI Knock Outs for IRAK3:

Animal Model Products

miRNA for IRAK3 Gene

miRTarBase miRNAs that target IRAK3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRAK3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for IRAK3 Gene

Localization for IRAK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRAK3 Gene COMPARTMENTS Subcellular localization image for IRAK3 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17379480
GO:0005737 cytoplasm IDA 17379480
GO:0045323 interleukin-1 receptor complex IBA --
genes like me logo Genes that share ontologies with IRAK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRAK3 Gene

Pathways for IRAK3 Gene

genes like me logo Genes that share pathways with IRAK3: view

Pathways by source for IRAK3 Gene

2 Cell Signaling Technology pathways for IRAK3 Gene
1 BioSystems pathway for IRAK3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • T-Cell Anergy & Immune Tolerance in human,mouse,rat

Gene Ontology (GO) - Biological Process for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IC 12150927
GO:0002224 toll-like receptor signaling pathway IBA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0006468 protein phosphorylation IDA 10383454
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with IRAK3: view

Compounds for IRAK3 Gene

(3) HMDB Compounds for IRAK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Novoseek inferred chemical compound relationships for IRAK3 Gene

Compound -log(P) Hits PubMed IDs
endotoxin 52.8 5
genes like me logo Genes that share compounds with IRAK3: view

Transcripts for IRAK3 Gene

Unigene Clusters for IRAK3 Gene

Interleukin-1 receptor-associated kinase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRAK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK3 Gene

No ASD Table

Relevant External Links for IRAK3 Gene

GeneLoc Exon Structure for
IRAK3
ECgene alternative splicing isoforms for
IRAK3

Expression for IRAK3 Gene

mRNA expression in normal human tissues for IRAK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRAK3 Gene

This gene is overexpressed in Whole Blood (16.2).

Protein differential expression in normal tissues for IRAK3 Gene

This gene is overexpressed in Lung (46.3), Bone marrow mesenchymal stem cell (12.7), and Monocytes (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IRAK3 Gene

SOURCE GeneReport for Unigene cluster for IRAK3 Gene Hs.369265

mRNA Expression by UniProt/SwissProt for IRAK3 Gene

Q9Y616-IRAK3_HUMAN
Tissue specificity: Expressed predominantly in peripheral blood lymphocytes.
genes like me logo Genes that share expressions with IRAK3: view

Expression partners for IRAK3 Gene

In Situ Assay Products

Orthologs for IRAK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRAK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IRAK3 35
  • 85.16 (n)
  • 81.71 (a)
IRAKM 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRAK3 35
  • 87.98 (n)
  • 82.79 (a)
IRAK3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irak3 35
  • 79.64 (n)
  • 76.17 (a)
Irak3 16
Irak3 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IRAK3 35
  • 99.55 (n)
  • 99.16 (a)
IRAK3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irak3 35
  • 80.48 (n)
  • 77.01 (a)
oppossum
(Monodelphis domestica)
Mammalia IRAK3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRAK3 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii irak3 35
  • 54.54 (n)
  • 47.71 (a)
irak3 36
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pll 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pik-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for IRAK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IRAK3 Gene

ENSEMBL:
Gene Tree for IRAK3 (if available)
TreeFam:
Gene Tree for IRAK3 (if available)

Paralogs for IRAK3 Gene

Paralogs for IRAK3 Gene

genes like me logo Genes that share paralogs with IRAK3: view

Variants for IRAK3 Gene

Sequence variations from dbSNP and Humsavar for IRAK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs726302 -- 66,232,377(-) ATGGC(C/T)GTGGA intron-variant
rs1058221 -- 66,253,201(+) TATTC(A/G)GAATA utr-variant-3-prime
rs1058222 -- 66,253,823(+) AGATT(A/T)AAAAA utr-variant-3-prime
rs1143957 -- 66,252,672(-) TCACT(A/C/G/T)ACATA utr-variant-3-prime
rs1152884 -- 66,206,971(-) gataa(C/T)ttaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRAK3 Gene

Variant ID Type Subtype PubMed ID
nsv899215 CNV Loss 21882294
nsv899216 CNV Gain 21882294
esv29230 CNV Loss 19812545
esv7862 CNV Gain 19470904

Relevant External Links for IRAK3 Gene

HapMap Linkage Disequilibrium report
IRAK3
Human Gene Mutation Database (HGMD)
IRAK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK3 Gene

Disorders for IRAK3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IRAK3 Gene in MalaCards »

(3) Diseases for IRAK3 Gene including...

(1) OMIM Diseases for IRAK3 Gene (604459)

UniProtKB/Swiss-Prot

IRAK3_HUMAN
  • Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:17503328}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(4) Novoseek inferred disease relationships for IRAK3 Gene

Disease -log(P) Hits PubMed IDs
sepsis 34.6 5
inflammation 29.7 1
necrosis 27.8 3
tumors 7.88 4

Relevant External Links for IRAK3

Genetic Association Database (GAD)
IRAK3
Human Genome Epidemiology (HuGE) Navigator
IRAK3
genes like me logo Genes that share disorders with IRAK3: view

No data available for University of Copenhagen DISEASES and Genatlas for IRAK3 Gene

Publications for IRAK3 Gene

  1. Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases. (PMID: 17558906) Weersma R.K. … Dijkstra G. (Scand. J. Gastroenterol. 2007) 3 23 48
  2. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PMID: 18987746) Kimman T.G. … Kerkhof M. (PLoS ONE 2008) 3 23 48
  3. No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort. (PMID: 19013233) Beygo J. … Hoffjan S. (Mol. Cell. Probes 2009) 3 23 48
  4. IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PMID: 10383454) Wesche H. … Cao Z. (J. Biol. Chem. 1999) 2 3 4
  5. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. (PMID: 17503328) Balaci L. … Pilia G. (Am. J. Hum. Genet. 2007) 3 4 48

Products for IRAK3 Gene

  • Addgene plasmids for IRAK3

Sources for IRAK3 Gene

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