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Aliases for IRAK3 Gene

Aliases for IRAK3 Gene

  • Interleukin 1 Receptor Associated Kinase 3 2 3 5
  • IL-1 Receptor-Associated Kinase M 3 4
  • Interleukin-1 Receptor-Associated Kinase 3 2
  • EC 4
  • IRAK-3 4
  • IRAK-M 4
  • ASRT5 3
  • IRAKM 3

External Ids for IRAK3 Gene

Previous GeneCards Identifiers for IRAK3 Gene

  • GC12P065974
  • GC12P066443
  • GC12P066299
  • GC12P064869
  • GC12P066582
  • GC12P063633

Summaries for IRAK3 Gene

Entrez Gene Summary for IRAK3 Gene

  • This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for IRAK3 Gene

IRAK3 (Interleukin 1 Receptor Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include Asthma Susceptibility 5 and Pleuropneumonia. Among its related pathways are MyD88 cascade initiated on plasma membrane and Toll Comparative Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK1.

UniProtKB/Swiss-Prot for IRAK3 Gene

  • Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Gene Wiki entry for IRAK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK3 Gene

Genomics for IRAK3 Gene

Regulatory Elements for IRAK3 Gene

Enhancers for IRAK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRAK3 on UCSC Golden Path with GeneCards custom track

Promoters for IRAK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IRAK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRAK3 Gene

66,188,879 bp from pter
66,254,622 bp from pter
65,744 bases
Plus strand

Genomic View for IRAK3 Gene

Genes around IRAK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRAK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRAK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK3 Gene

Proteins for IRAK3 Gene

  • Protein details for IRAK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor-associated kinase 3
    Protein Accession:
    Secondary Accessions:
    • B4DQ57

    Protein attributes for IRAK3 Gene

    596 amino acids
    Molecular mass:
    67767 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IRAK3 Gene


neXtProt entry for IRAK3 Gene

Proteomics data for IRAK3 Gene at MOPED

Post-translational modifications for IRAK3 Gene

  • Ubiquitination at Lys 379
  • Modification sites at PhosphoSitePlus

Other Protein References for IRAK3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRAK3 (IRAK3)
  • Abcam antibodies for IRAKM

No data available for DME Specific Peptides for IRAK3 Gene

Domains & Families for IRAK3 Gene

Gene Families for IRAK3 Gene

Protein Domains for IRAK3 Gene

Suggested Antigen Peptide Sequences for IRAK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 death domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK3: view

Function for IRAK3 Gene

Molecular function for IRAK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Enzyme Numbers (IUBMB) for IRAK3 Gene

genes like me logo Genes that share phenotypes with IRAK3: view

Animal Models for IRAK3 Gene

MGI Knock Outs for IRAK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IRAK3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRAK3 Gene

Localization for IRAK3 Gene

Subcellular locations from

Jensen Localization Image for IRAK3 Gene COMPARTMENTS Subcellular localization image for IRAK3 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IRAK3 Gene

Pathways & Interactions for IRAK3 Gene

genes like me logo Genes that share pathways with IRAK3: view

Pathways by source for IRAK3 Gene

1 Cell Signaling Technology pathway for IRAK3 Gene
1 BioSystems pathway for IRAK3 Gene

SIGNOR curated interactions for IRAK3 Gene


Gene Ontology (GO) - Biological Process for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IC 12150927
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0006468 protein phosphorylation IEA,IDA 10383454
GO:0007165 signal transduction IEA --
GO:0009615 response to virus IC 12150927
genes like me logo Genes that share ontologies with IRAK3: view

Drugs & Compounds for IRAK3 Gene

(2) Drugs for IRAK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(2) Additional Compounds for IRAK3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with IRAK3: view

Transcripts for IRAK3 Gene

Unigene Clusters for IRAK3 Gene

Interleukin-1 receptor-associated kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK3 Gene

No ASD Table

Relevant External Links for IRAK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRAK3 Gene

mRNA expression in normal human tissues for IRAK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRAK3 Gene

This gene is overexpressed in Whole Blood (x16.2).

Protein differential expression in normal tissues from HIPED for IRAK3 Gene

This gene is overexpressed in Lung (46.3), Bone marrow mesenchymal stem cell (12.7), and Monocytes (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRAK3 Gene

SOURCE GeneReport for Unigene cluster for IRAK3 Gene Hs.369265

mRNA Expression by UniProt/SwissProt for IRAK3 Gene

Tissue specificity: Expressed predominantly in peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with IRAK3: view

Protein tissue co-expression partners for IRAK3 Gene

Primer Products

Orthologs for IRAK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRAK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IRAK3 35
  • 85.16 (n)
  • 81.71 (a)
  • 79 (a)
(Canis familiaris)
Mammalia IRAK3 35
  • 87.98 (n)
  • 82.79 (a)
IRAK3 36
  • 80 (a)
(Mus musculus)
Mammalia Irak3 35
  • 79.64 (n)
  • 76.17 (a)
Irak3 16
Irak3 36
  • 75 (a)
(Pan troglodytes)
Mammalia IRAK3 35
  • 99.55 (n)
  • 99.16 (a)
IRAK3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Irak3 35
  • 80.48 (n)
  • 77.01 (a)
(Monodelphis domestica)
Mammalia IRAK3 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia IRAK3 36
  • 57 (a)
(Danio rerio)
Actinopterygii irak3 35
  • 54.54 (n)
  • 47.71 (a)
irak3 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta pll 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea pik-1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for IRAK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IRAK3 Gene

Gene Tree for IRAK3 (if available)
Gene Tree for IRAK3 (if available)

Paralogs for IRAK3 Gene

Paralogs for IRAK3 Gene

genes like me logo Genes that share paralogs with IRAK3: view

Variants for IRAK3 Gene

Sequence variations from dbSNP and Humsavar for IRAK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1152888 - 66,211,448(+) AAGGA(A/G)TACTG reference, missense
rs11465972 - 66,228,291(+) TCGGT(A/G)TATTA reference, missense
rs35823766 - 66,228,288(+) GAATC(A/C/G/T)GTATA reference, missense
VAR_035212 -
VAR_035213 -

Structural Variations from Database of Genomic Variants (DGV) for IRAK3 Gene

Variant ID Type Subtype PubMed ID
nsv899215 CNV Loss 21882294
nsv899216 CNV Gain 21882294
esv29230 CNV Loss 19812545
esv7862 CNV Gain 19470904

Variation tolerance for IRAK3 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRAK3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK3 Gene

Disorders for IRAK3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IRAK3 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
asthma susceptibility 5
  • asthma-related traits 5
  • acute and fulminating melioidosis
buschke-ollendorff syndrome
  • osteopoikilosis
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search IRAK3 in MalaCards View complete list of genes associated with diseases


  • Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:17503328}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IRAK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRAK3: view

No data available for Genatlas for IRAK3 Gene

Publications for IRAK3 Gene

  1. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. (PMID: 17503328) Balaci L. … Pilia G. (Am. J. Hum. Genet. 2007) 3 4 48 67
  2. No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort. (PMID: 19013233) Beygo J. … Hoffjan S. (Mol. Cell. Probes 2009) 3 23
  3. Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression. (PMID: 19414798) Zacharioudaki V. … Tsatsanis C. (J. Immunol. 2009) 3 23
  4. Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides. (PMID: 18354163) Shen W. … Ladisch S. (J. Immunol. 2008) 3 23
  5. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PMID: 18987746) Kimman T.G. … Kerkhof M. (PLoS ONE 2008) 3 23

Products for IRAK3 Gene

Sources for IRAK3 Gene