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Aliases for IRAK3 Gene

Aliases for IRAK3 Gene

  • Interleukin 1 Receptor Associated Kinase 3 2 3 5
  • Interleukin-1 Receptor-Associated Kinase 3 2 3
  • IL-1 Receptor-Associated Kinase M 3 4
  • EC 2.7.11.1 4
  • IRAK-3 4
  • IRAK-M 4
  • ASRT5 3
  • IRAKM 3

External Ids for IRAK3 Gene

Previous GeneCards Identifiers for IRAK3 Gene

  • GC12P065974
  • GC12P066443
  • GC12P066299
  • GC12P064869
  • GC12P066582
  • GC12P063633

Summaries for IRAK3 Gene

Entrez Gene Summary for IRAK3 Gene

  • This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for IRAK3 Gene

IRAK3 (Interleukin 1 Receptor Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include Asthma Susceptibility 5 and Pleuropneumonia. Among its related pathways are Toll Comparative Pathway and Interleukin-1 signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MIR718.

UniProtKB/Swiss-Prot for IRAK3 Gene

  • Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Tocris Summary for IRAK3 Gene

  • The IRAKs (Interleukin-1 receptor-associated kinases) are serine-threonine kinases, EC 2.7.11.1, that are essential regulators of IL-1R and TLR-mediated signaling. Four IRAK isoforms have been identified to date, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.

Gene Wiki entry for IRAK3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK3 Gene

Genomics for IRAK3 Gene

Regulatory Elements for IRAK3 Gene

Enhancers for IRAK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F066190 1 FANTOM5 ENCODE 37.1 +2.2 2220 1.4 WRNIP1 KLF17 ZIC2 ZBTB48 FOS PRDM10 ZNF600 MTA2 ATF2 ZNF692 IRAK3 LLPH-AS1 TMBIM4 MIR6502 PIR44949
GH12F066186 1 FANTOM5 ENCODE 34.9 -0.2 -246 3.3 USF1 MAX EBF1 ZBTB40 RELA POLR2A ZNF366 CREM EZH2 RNF2 IRAK3 LLPH-AS1 LLPH ENSG00000256072 TMBIM4 HELB MIR6502
GH12F066267 1.5 FANTOM5 Ensembl ENCODE 26.2 +80.0 80022 2.6 CTCF PKNOX1 TEAD4 ZNF175 ZBTB40 ZNF644 RAD21 RELA TEAD3 CTBP1 HELB IRAK3 TMBIM4 PDCL3P7 ENSG00000256072
GH12F066234 0.9 FANTOM5 ENCODE 21.8 +46.3 46308 1.4 CTCF ATF1 ZNF76 GLIS2 POLR2A PATZ1 EED PRDM10 ZNF600 FOSL2 IRAK3 TMBIM4 MIR6502 ENSG00000228144 HELB ENSG00000256072 LLPH LLPH-AS1 RBMS1P1 PIR44949
GH12F066213 0.4 FANTOM5 19.7 +24.4 24381 0.3 IRAK3 PIR44949 MIR6502
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IRAK3 on UCSC Golden Path with GeneCards custom track

Promoters for IRAK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000432300 921 2001 USF1 MAX EBF1 ZBTB40 POLR2A PRDM10 CREM EZH2 RNF2 USF2

Genomic Location for IRAK3 Gene

Chromosome:
12
Start:
66,188,879 bp from pter
End:
66,254,622 bp from pter
Size:
65,744 bases
Orientation:
Plus strand

Genomic View for IRAK3 Gene

Genes around IRAK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRAK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRAK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK3 Gene

Proteins for IRAK3 Gene

  • Protein details for IRAK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y616-IRAK3_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase 3
    Protein Accession:
    Q9Y616
    Secondary Accessions:
    • B4DQ57

    Protein attributes for IRAK3 Gene

    Size:
    596 amino acids
    Molecular mass:
    67767 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IRAK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRAK3 Gene

Post-translational modifications for IRAK3 Gene

  • Ubiquitination at Lys 379
  • Modification sites at PhosphoSitePlus

Other Protein References for IRAK3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRAK3 (IRAK3)
  • Abcam antibodies for IRAK3
  • Cloud-Clone Corp. Antibodies for IRAK3

No data available for DME Specific Peptides for IRAK3 Gene

Domains & Families for IRAK3 Gene

Gene Families for IRAK3 Gene

Protein Domains for IRAK3 Gene

Suggested Antigen Peptide Sequences for IRAK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y616

UniProtKB/Swiss-Prot:

IRAK3_HUMAN :
  • Contains 1 death domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Domain:
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK3: view

Function for IRAK3 Gene

Molecular function for IRAK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

Enzyme Numbers (IUBMB) for IRAK3 Gene

Gene Ontology (GO) - Molecular Function for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10383454
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 10383454
GO:0005524 ATP binding IDA 10383454
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with IRAK3: view
genes like me logo Genes that share phenotypes with IRAK3: view

Animal Models for IRAK3 Gene

MGI Knock Outs for IRAK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IRAK3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IRAK3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRAK3 Gene

Localization for IRAK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRAK3 Gene COMPARTMENTS Subcellular localization image for IRAK3 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17379480
GO:0005737 cytoplasm IDA 17379480
genes like me logo Genes that share ontologies with IRAK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRAK3 Gene

Pathways & Interactions for IRAK3 Gene

genes like me logo Genes that share pathways with IRAK3: view

Pathways by source for IRAK3 Gene

SIGNOR curated interactions for IRAK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for IRAK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IC 12150927
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0006468 protein phosphorylation IDA 10383454
GO:0007165 signal transduction IEA --
GO:0009615 response to virus IC 12150927
genes like me logo Genes that share ontologies with IRAK3: view

Drugs & Compounds for IRAK3 Gene

(5) Drugs for IRAK3 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
IRAK inhibitor 2 Pharma 0
IRAK inhibitor 3 Pharma 0
IRAK inhibitor 4 Pharma IRAK inhibitor 0
Magnesium Nutra 0

(3) Additional Compounds for IRAK3 Gene - From: Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
IRAK1/4 Inhibitor I
509093-47-4

(1) Tocris Compounds for IRAK3 Gene

Compound Action Cas Number
IRAK1/4 Inhibitor I IRAK4 and IRAK1 inhibitor 509093-47-4

(3) ApexBio Compounds for IRAK3 Gene

Compound Action Cas Number
IRAK inhibitor 2 928333-30-6
IRAK inhibitor 3 1012343-93-9
IRAK inhibitor 4 IRAK inhibitor 1012104-68-5
genes like me logo Genes that share compounds with IRAK3: view

Transcripts for IRAK3 Gene

Unigene Clusters for IRAK3 Gene

Interleukin-1 receptor-associated kinase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IRAK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK3 Gene

No ASD Table

Relevant External Links for IRAK3 Gene

GeneLoc Exon Structure for
IRAK3
ECgene alternative splicing isoforms for
IRAK3

Expression for IRAK3 Gene

mRNA expression in normal human tissues for IRAK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRAK3 Gene

This gene is overexpressed in Whole Blood (x16.2).

Protein differential expression in normal tissues from HIPED for IRAK3 Gene

This gene is overexpressed in Lung (46.3), Bone marrow mesenchymal stem cell (12.7), and Monocytes (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRAK3 Gene



Protein tissue co-expression partners for IRAK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRAK3 Gene:

IRAK3

SOURCE GeneReport for Unigene cluster for IRAK3 Gene:

Hs.369265

mRNA Expression by UniProt/SwissProt for IRAK3 Gene:

Q9Y616-IRAK3_HUMAN
Tissue specificity: Expressed predominantly in peripheral blood lymphocytes.
genes like me logo Genes that share expression patterns with IRAK3: view

Primer Products

Orthologs for IRAK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRAK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRAK3 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia IRAK3 34 35
  • 87.98 (n)
cow
(Bos Taurus)
Mammalia IRAK3 34
  • 85.16 (n)
IRAKM 35
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irak3 34
  • 80.48 (n)
mouse
(Mus musculus)
Mammalia Irak3 34 16 35
  • 79.64 (n)
oppossum
(Monodelphis domestica)
Mammalia IRAK3 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRAK3 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii irak3 34 35
  • 54.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta pll 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pik-1 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for IRAK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IRAK3 Gene

ENSEMBL:
Gene Tree for IRAK3 (if available)
TreeFam:
Gene Tree for IRAK3 (if available)

Paralogs for IRAK3 Gene

Paralogs for IRAK3 Gene

genes like me logo Genes that share paralogs with IRAK3: view

Variants for IRAK3 Gene

Sequence variations from dbSNP and Humsavar for IRAK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs776951445 Uncertain significance 66,247,841(+) AATAA(-/C)AATTT reference, frameshift-variant
rs121912630 other 66,203,804(+) GTCCT(A/G)GGCAC intron-variant, reference, stop-gained
rs10506481 -- 66,250,331(+) TCATA(C/T)TCACA upstream-variant-2KB, utr-variant-3-prime
rs1058221 -- 66,253,201(+) TATTC(A/G)GAATA utr-variant-3-prime
rs1058222 -- 66,253,823(+) AGATT(A/T)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IRAK3 Gene

Variant ID Type Subtype PubMed ID
esv29230 CNV loss 19812545
esv3629799 CNV loss 21293372
esv3892211 CNV loss 25118596
esv7862 CNV gain 19470904
nsv976637 CNV duplication 23825009

Variation tolerance for IRAK3 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRAK3 Gene

Human Gene Mutation Database (HGMD)
IRAK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRAK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK3 Gene

Disorders for IRAK3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IRAK3 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
asthma susceptibility 5
  • asthma-related traits 5
pleuropneumonia
melioidosis
  • melioidosis, susceptibility to melioidosis, resistance to, included
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search IRAK3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IRAK3_HUMAN
  • Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269 PubMed:17503328}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IRAK3

Genetic Association Database (GAD)
IRAK3
Human Genome Epidemiology (HuGE) Navigator
IRAK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRAK3
genes like me logo Genes that share disorders with IRAK3: view

No data available for Genatlas for IRAK3 Gene

Publications for IRAK3 Gene

  1. No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort. (PMID: 19013233) Beygo J. … Hoffjan S. (Mol. Cell. Probes 2009) 3 22 46 64
  2. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PMID: 18987746) Kimman T.G. … Kerkhof M. (PLoS ONE 2008) 3 22 46 64
  3. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. (PMID: 17503328) Balaci L. … Pilia G. (Am. J. Hum. Genet. 2007) 3 4 46 64
  4. Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases. (PMID: 17558906) Weersma R.K. … Dijkstra G. (Scand. J. Gastroenterol. 2007) 3 22 46 64
  5. IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PMID: 10383454) Wesche H. … Cao Z. (J. Biol. Chem. 1999) 2 3 4 64

Products for IRAK3 Gene

Sources for IRAK3 Gene

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