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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IRAK2 Gene

protein-coding GIFtS: 61
GCID: GC03P010206

interleukin-1 receptor-associated kinase 2

Explore 11 diseases affiliated with
IRAK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin-1 Receptor-Associated Kinase 2¹ ²
IRAK-2² ³
Interleukin-1 Receptor Associated Kinase-2²
Interleukin-1 Receptor-Associated Kinase-Like 2²

External Ids:	HGNC: 6113¹	Entrez Gene: 3656²	Ensembl: ENSG00000134070⁷	OMIM: 603304⁵	UniProtKB: O43187³

Export aliases for IRAK2 gene to outside databases

Previous GC identifers: GC03P010135 GC03P010198 GC03P010181 GC03P010142

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRAK2:

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become

associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the

IL1-induced upregulation of NF-kappaB. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187

Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades

leading to transcriptional up-regulation and mRNA stabilization

Gene Wiki entry for IRAK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IRAK2 gene promoter:
AP-1 ATF-2 MyoD NF-kappaB C/EBPalpha NF-kappaB2 NF-kappaB1 Hlf ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRAK2 promoter sequence

Search SABiosciences Chromatin IP Primers for IRAK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.2

IRAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P010206: view genomic region (about GC identifiers)

Start:	10,206,549 bp from pter	End:	10,285,427 bp from pter
Size:	78,879 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187 (See protein sequence)

Recommended Name: Interleukin-1 receptor-associated kinase-like 2

Size: 625 amino acids; 69433 Da

Subunit: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from

the IL-1 receptor following the binding of PELI1

Caution: Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme

has been shown to be catalytically inactive

1 PDB 3D structure from and Proteopedia for IRAK2:

3MOP (3D)

Secondary accessions: B4DQZ6 Q08AG6 Q5K546

Explore the universe of human proteins at neXtProt for IRAK2: NX_O43187

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43187

IRAK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001561.3

ENSEMBL proteins:

ENSP00000256458

Reactome Protein details: O43187
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for IRAK2
	GenScript Custom Purified and Recombinant Proteins Services for IRAK2
	Novus Biologicals IRAK2 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IRAK2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0009986	cell surface	IDA	12493773
GO:0010008	endosome membrane	TAS	--

IRAK2 for ontologies About GeneDecksing

IRAK2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IRAK2
	Cell Signaling Technology (CST) Antibodies for IRAK2
	OriGene Antibodies: IRAK2 OriGene Custom Antibody Services for IRAK2
	GenScript Custom Superior Antibodies Services for IRAK2
	Novus Biologicals IRAK2 Antibodies
	Abcam antibodies for IRAK2
	Uscn Antibodies for IRAK2
	ThermoFisher Antibodies for IRAK2

Assay Products for IRAK2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IRAK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IRAK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IRAK2 for domains About GeneDecksing

4 InterPro domains/families:

IPR011029 DEATH-like_dom

IPR011009 Kinase-like_dom

IPR000488 Death_domain

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry O43187

ProtoNet protein and cluster: O43187

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187

Domain: The protein kinase domain is predicted to be catalytically inactive

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily

Similarity: Contains 1 death domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187

Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades

leading to transcriptional up-regulation and mRNA stabilization

miRNA Products:		miRTarBase miRNAs that target IRAK2: hsa-mir-146a (MIRT000304)

		OriGene 3'-UTR Clone: IRAK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK2
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK2 (see all 32):
		hsa-miR-320a hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-875-3p hsa-miR-15a hsa-miR-503 hsa-miR-302e

		SwitchGear 3'UTR luciferase reporter plasmid: IRAK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK2 (see all 7) OriGene shRNA RFP: IRAK2 OriGene siRNA: IRAK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IRAK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IRAK2 (NM_001570)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IRAK2
		Search LifeMap BioReagents cell lines for IRAK2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0042803	protein homodimerization activity	IPI	10383454
GO:0046982	protein heterodimerization activity	IPI	10383454

IRAK2 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for IRAK2:

Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella-containin
Decreased mitotic index	Decreased substrate adherent c	Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for IRAK2: Irak2^tm1Jth Irak2^tm1Aki
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Irak2):

homeostasis/metabolism

immune system

mortality/aging

IRAK2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

Toll Comparative Pathway

Toll Comparative Pathway	1.00	Immune response MIF in innate immunity response	0.46
TLR-TRIF Pathway	0.61	IL-1 Pathway	0.39
Immune response_MIF in innate immunity response	0.46	iNOS Signaling	0.34

Signal Transduction

	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2	0.67			IRAK2 mediated activation of TAK1 complex	0.40
	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane	0.67			IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.40

Immune response_Bacterial infections in normal airways

	Immune response_Bacterial infections in normal airways	1.00			IL-1 beta-dependent CFTR expression	0.43
	Bacterial infections in CF airways	0.78

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	1.00			TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.56
	activated TAK1 mediates p38 MAPK activation	0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for IRAK2

	Transcription NF-kB signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Immune response MIF in innate immunity response

1 R&D Systems Pathway for IRAK2

Toll-Like receptor Signaling Pathways

5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRAK2 (see all 12)

	MAPK Signaling
	14-3-3 Induced Apoptosis
	NF-KappaB (p50-p65) Pathway
	Toll-Like Receptors Pathway
	TRAF Pathway

2 Cell Signaling Technology (CST) Pathways for IRAK2

	Lymphocyte Signaling
	NF-kappaB Signaling

5/9 GeneGo (Thomson Reuters) Pathways for IRAK2 (see all 9)

	Mucin expression in CF via TLRs, EGFR signaling pathways
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Development NOTCH1-mediated pathway for NF-KB activity modulation
	Transcription NF-kB signaling pathway

1 BioSystems Pathway for IRAK2

IL-1 Signaling Pathway

5/34 Reactome Pathways for IRAK2 (see all 34)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	IRAK2 mediated activation of TAK1 complex
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation

3 Kegg Pathways (Kegg details for IRAK2):

	Apoptosis
	Neurotrophin signaling pathway
	Tuberculosis

IRAK2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IRAK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/70 Interacting proteins for IRAK2 (O43187^{1, 2, 3} ENSP00000256458⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IRAK1	P51617¹^,²^,³, ENSP00000358997⁴	EBI-447733,EBI-358664 MINT-50487 I2D: score=5 STRING: ENSP00000358997
TRAF6	Q9Y4K3¹^,²^,³	EBI-447733,EBI-359276 MINT-50485 I2D: score=6
TIRAP	P58753¹^,³, ENSP00000376445⁴	EBI-447733,EBI-528644 I2D: score=4 STRING: ENSP00000376445
ZC3H12A	Q5D1E8¹^,³, ENSP00000362174⁴	EBI-447733,EBI-747793 I2D: score=1 STRING: ENSP00000362174
IRAK3	Q9Y616¹^,²^,³, ENSP00000261233⁴	EBI-447733,EBI-447690 MINT-50489 I2D: score=4 STRING: ENSP00000261233

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	--
GO:0001959	regulation of cytokine-mediated signaling pathway	IMP	10383454
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	10383454
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--

IRAK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IRAK2

2 HMDB Compounds for IRAK2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about IRAK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IRAK2 gene:

NM_001570.3

Unigene Cluster for IRAK2:

Interleukin-1 receptor-associated kinase 2

Hs.449207 [show with all ESTs]

Unigene Representative Sequence: NM_001570

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000256458(uc003bve.1)

miRNA Products:		OriGene 3'-UTR Clone: IRAK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK2
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK2 (see all 32):
		hsa-miR-320a hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-875-3p hsa-miR-15a hsa-miR-503 hsa-miR-302e

		SwitchGear 3'UTR luciferase reporter plasmid: IRAK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK2 (see all 7) OriGene shRNA RFP: IRAK2 OriGene siRNA: IRAK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IRAK2 (NM_001570)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IRAK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK2

Additional cDNA sequence:

AF026273.1 AJ496794.1 AK299033.1 AK312841.1 BC125184.1

3 DOTS entries:

DT.40123269 DT.102826610 DT.75173395

24/31 AceView cDNA sequences (see all 31):

AW848508 AI891138 AW848229 NM_001570 BG288146 CD612048 AL567543 AL556221

BG287255 BX329231 BX369510 BG259609 BG431557 BX369509 BI760724 CD612050

AI246590 BM990622 BG682610 BM976377 CD612044 CD612045 AF026273 AA876147

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IRAK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGAAAGA

About this image
See IRAK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRAK2

SOURCE GeneReport for Unigene cluster: Hs.449207

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187

Tissue specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and

peripheral blood leukocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including IRAK2:

Toll-Like Receptor Signaling Pathway in human mouse rat

NFKB Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IRAK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRAK2 gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IRAK2¹	interleukin-1 receptor-associated kinase 2	57.96(n) 49.25(a)		416118 NM_001030605.1 NP_001025776.1
lizard (Anolis carolinensis)	Reptilia	IRAK2⁶	--	42(a)	1 ↔ 1	GL343273.1(894482-907480)
fruit fly (Drosophila melanogaster)	Insecta	pll⁶	pelle	21(a)	1 → many	3R(23076853-23078902)
worm (Caenorhabditis elegans)	Secernentea	pik-1⁶	Pelle/IL-1 receptor associated Kinase (IRAK) famil...	19(a)	1 → many	IV(13416768-13421501)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G56890⁶ AT3G62220⁶ (see all 38)	protein kinase-domain containing protein (see all 38)	8(a) 24(a) (see all 38)	many ↔ many many ↔ many (see all 38)	5(23010523-23015671) 3(23029100-23031155)
rice (Oryza sativa)	Liliopsida	-- -- (see all 35)	retrotransposon protein, putative, unclassified, e... protein kinase family protein, putative, expressed... (see all 35)	9(a) 9(a) (see all 35)	many ↔ many many ↔ many (see all 35)	1(5108949-5116013) 1(29482162-29491511)

ENSEMBL Gene Tree for IRAK2 (if available)
TreeFam Gene Tree for IRAK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IRAK2 gene

IRAK1² IRAK4² IRAK3²

IRAK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9852820^1,2	C,	--	10204655(+)	`ggtctC/Gactct`	1	--	us2k¹		0	--	--	--	--
rs142325055^1,2		--	10204784(+)	`TGCCTA/GGCTAA`	1	--	us2k¹		0	--	--	--	--
rs192575885^1,2		--	10204806(+)	`ACAGGA/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs11465846^1,2	C,	--	10204901(+)	`GAGCCG/ACNGCA`	1	--	us2k¹		3		NA EU	86
rs183825^1,2	C,F,	--	10204903(+)	`GCCGCC/TGCACC`	1	--	us2k¹		8		NA EU EA	332
rs183731997^1,2		--	10205025(+)	`ACTCCC/TTTTTA`	1	--	us2k¹		0	--	--	--	--
rs151320610^1,2		--	10205029(+)	`CCTTTC/TACCAC`	1	--	us2k¹		0	--	--	--	--
rs72563173^1,2	F	--	10205049(+)	`TTATTCTTTC TTTT/-CTTTC`	1	--	us2k¹		5		MN	408
rs201525054^1,2		--	10205058(+)	`CTTTT-/CTTTCT`	1	--	us2k¹		0	--	--	--	--
rs200121845^1,2		--	10205065(+)	`TCTTT-/CTTTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IRAK2 (10206549 - 10285427 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for IRAK2
7 CNVs: 63391 91182 39323 79671 62030 1052 22725

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IRAK2 for disorders           About GeneDecksing

OMIM gene information: 603304    OMIM disorders: --

11 diseases for IRAK2:    About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia pituitary adenoma vaccinia

adenoma osteoporosis alzheimer's disease meningioma

leukemia prostatitis tuberculosis

2 Novoseek disease relationships for IRAK2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	34.2	1	18070880 (1)
tumors	10.5	1	18070880 (1)

Human Genome Epidemiology (HuGE) Navigator: IRAK2 (18 documents)

Export disorders for IRAK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IRAK2 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with IRAK2)

Utopia: connect your pdf to the dynamic
world of online information

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (PubMed id 9374458)^{1, 2, 3, 9} Muzio M.... Dixit V.M. (1997)
IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PubMed id 10383454)^{1, 2, 9} Wesche H.... Cao Z. (1999)
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. (PubMed id 20485341)^{1, 2} Lin S.C....Wu H. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. (PubMed id 17878161)^{1, 9} Keating S.E....Bowie A.G. (2007)
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. (PubMed id 11744690)^{1, 9} McDermott E.P. and O'Neill L.A. (2002)
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PubMed id 12721283)^{1, 9} Bin L.H.... Shu H.B. (2003)
Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter. (PubMed id 15670593)^{1, 9} Kuzmin I....Lerman M.I. (2005)
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PubMed id 11544529)^{1, 9} Fitzgerald K.A.... O'Neill L.A.J. (2001)
Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis. (PubMed id 18996842)^{1, 9} Elzinga B.M....McCarthy J.V. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3656	HGNC: 6113	AceView: IRAK2	Ensembl:ENSG00000134070	euGenes: HUgn3656
ECgene: IRAK2	Kegg: 3656	H-InvDB: IRAK2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IRAK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IRAK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IRAK2 gene:
Search GeneIP for patents involving IRAK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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interleukin-1 receptor-associated kinase 2

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interleukin-1 receptor-associated kinase 2

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