Aliases for IRAK2 Gene
External Ids for IRAK2 Gene
Previous GeneCards Identifiers for IRAK2 Gene
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRAK2 Gene
IRAK2 (Interleukin 1 Receptor Associated Kinase 2) is a Protein Coding gene. Diseases associated with IRAK2 include lymphocytic colitis and cervix disease. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK1.
UniProtKB/Swiss-Prot for IRAK2 Gene
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.