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Aliases for IRAK2 Gene

Aliases for IRAK2 Gene

  • Interleukin-1 Receptor-Associated Kinase 2 2 3
  • IRAK-2 3 4
  • Interleukin-1 Receptor Associated Kinase-2 3

External Ids for IRAK2 Gene

Previous GeneCards Identifiers for IRAK2 Gene

  • GC03P010135
  • GC03P010198
  • GC03P010181
  • GC03P010206
  • GC03P010142

Summaries for IRAK2 Gene

Entrez Gene Summary for IRAK2 Gene

  • IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRAK2 Gene

IRAK2 (Interleukin-1 Receptor-Associated Kinase 2) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK4.

UniProtKB/Swiss-Prot for IRAK2 Gene

  • Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Gene Wiki entry for IRAK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK2 Gene

Genomics for IRAK2 Gene

Regulatory Elements for IRAK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRAK2 Gene

Chromosome:
3
Start:
10,164,865 bp from pter
End:
10,243,745 bp from pter
Size:
78,881 bases
Orientation:
Plus strand

Genomic View for IRAK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK2 Gene

Proteins for IRAK2 Gene

  • Protein details for IRAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43187-IRAK2_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase-like 2
    Protein Accession:
    O43187
    Secondary Accessions:
    • B4DQZ6
    • Q08AG6
    • Q5K546

    Protein attributes for IRAK2 Gene

    Size:
    625 amino acids
    Molecular mass:
    69433 Da
    Quaternary structure:
    • Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

    Three dimensional structures from OCA and Proteopedia for IRAK2 Gene

neXtProt entry for IRAK2 Gene

Proteomics data for IRAK2 Gene at MOPED

Post-translational modifications for IRAK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRAK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRAK2 (IRAK2)
  • Cloud-Clone Corp. Antibodies for IRAK2

No data available for DME Specific Peptides for IRAK2 Gene

Domains & Families for IRAK2 Gene

Gene Families for IRAK2 Gene

Protein Domains for IRAK2 Gene

Suggested Antigen Peptide Sequences for IRAK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43187

UniProtKB/Swiss-Prot:

IRAK2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK2: view

Function for IRAK2 Gene

Molecular function for IRAK2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Gene Ontology (GO) - Molecular Function for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 11544529
GO:0005524 ATP binding IEA --
GO:0042803 protein homodimerization activity IPI 10383454
genes like me logo Genes that share ontologies with IRAK2: view
genes like me logo Genes that share phenotypes with IRAK2: view

Animal Models for IRAK2 Gene

MGI Knock Outs for IRAK2:

Animal Model Products

miRNA for IRAK2 Gene

miRTarBase miRNAs that target IRAK2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRAK2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IRAK2 Gene

Localization for IRAK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRAK2 Gene COMPARTMENTS Subcellular localization image for IRAK2 gene
Compartment Confidence
cytosol 4
endosome 4
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with IRAK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRAK2 Gene

Pathways & Interactions for IRAK2 Gene

SuperPathways for IRAK2 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Toll Comparative Pathway
3 Bacterial infections in CF airways
4 Toll-Like receptor Signaling Pathways
5 Immune System
genes like me logo Genes that share pathways with IRAK2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0001959 regulation of cytokine-mediated signaling pathway IMP 10383454
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IRAK2: view

No data available for SIGNOR curated interactions for IRAK2 Gene

Drugs & Compounds for IRAK2 Gene

(1) Drugs for IRAK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for IRAK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with IRAK2: view

Transcripts for IRAK2 Gene

mRNA/cDNA for IRAK2 Gene

Unigene Clusters for IRAK2 Gene

Interleukin-1 receptor-associated kinase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRAK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK2 Gene

No ASD Table

Relevant External Links for IRAK2 Gene

GeneLoc Exon Structure for
IRAK2
ECgene alternative splicing isoforms for
IRAK2

Expression for IRAK2 Gene

mRNA expression in normal human tissues for IRAK2 Gene

mRNA differential expression in normal tissues according to GTEx for IRAK2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for IRAK2 Gene

This gene is overexpressed in Serum (25.7), Breast (21.6), and Bone marrow mesenchymal stem cell (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRAK2 Gene



SOURCE GeneReport for Unigene cluster for IRAK2 Gene Hs.449207

mRNA Expression by UniProt/SwissProt for IRAK2 Gene

O43187-IRAK2_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with IRAK2: view

Protein tissue co-expression partners for IRAK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IRAK2 Gene

Orthologs for IRAK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRAK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IRAK2 35
  • 84.81 (n)
  • 79.07 (a)
IRAK2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRAK2 35
  • 85.39 (n)
  • 81.28 (a)
VHL 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irak2 35
  • 76.34 (n)
  • 70.16 (a)
Irak2 16
Irak2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IRAK2 35
  • 97.96 (n)
  • 97.19 (a)
IRAK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irak2 35
  • 77.05 (n)
  • 71.43 (a)
oppossum
(Monodelphis domestica)
Mammalia IRAK2 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRAK2 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRAK2 35
  • 58.08 (n)
  • 50 (a)
IRAK2 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRAK2 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irak2 35
  • 47.31 (n)
  • 39.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta pll 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pik-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for IRAK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IRAK2 Gene

ENSEMBL:
Gene Tree for IRAK2 (if available)
TreeFam:
Gene Tree for IRAK2 (if available)

Paralogs for IRAK2 Gene

Paralogs for IRAK2 Gene

genes like me logo Genes that share paralogs with IRAK2: view

Variants for IRAK2 Gene

Sequence variations from dbSNP and Humsavar for IRAK2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs155265 -- 10,188,924(-) caata(C/T)tttgg intron-variant
rs155266 -- 10,189,044(-) gctcc(A/T)tgagg intron-variant
rs155582 -- 10,190,296(+) ttttt(G/T)gtgag intron-variant
rs155583 -- 10,191,840(-) CTGCC(A/G)TAATA intron-variant
rs155584 -- 10,192,484(-) TTATG(C/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRAK2 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
esv2664847 CNV Deletion 23128226
esv2724896 CNV Deletion 23290073
esv2674709 CNV Deletion 23128226
esv6737 CNV Loss 19470904
nsv821984 CNV Loss 20364138
nsv436398 CNV Deletion 17901297
esv23190 CNV Loss 19812545
dgv848e199 CNV Deletion 23128226
nsv437322 CNV Loss 16327808
nsv524674 CNV Loss 19592680
nsv522516 CNV Gain 19592680
nsv523288 CNV Loss 19592680
nsv876526 CNV Loss 21882294
esv2662021 CNV Deletion 23128226
nsv821985 CNV Loss 20364138
esv1307821 CNV Insertion 17803354

Variation tolerance for IRAK2 Gene

Residual Variation Intolerance Score: 96.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.55; 93.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRAK2 Gene

HapMap Linkage Disequilibrium report
IRAK2
Human Gene Mutation Database (HGMD)
IRAK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK2 Gene

Disorders for IRAK2 Gene

Relevant External Links for IRAK2

Genetic Association Database (GAD)
IRAK2
Human Genome Epidemiology (HuGE) Navigator
IRAK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRAK2
genes like me logo Genes that share disorders with IRAK2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRAK2 Gene

Publications for IRAK2 Gene

  1. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (PMID: 9374458) Muzio M. … Dixit V.M. (Science 1997) 2 23 67
  2. Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages. (PMID: 18992325) De Nardo D. … Scholz G.M. (Cell. Signal. 2009) 23 67
  3. Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis. (PMID: 18996842) Elzinga B.M. … McCarthy J.V. (J. Biol. Chem. 2009) 23 67
  4. In vivo profile of the human leukocyte microRNA response to endotoxemia. (PMID: 19284987) Schmidt W.M. … MA1ller M. (Biochem. Biophys. Res. Commun. 2009) 23 67
  5. Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. (PMID: 18070880) Piao W. … Medvedev A.E. (J. Biol. Chem. 2008) 23 67

Products for IRAK2 Gene

Sources for IRAK2 Gene

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