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Aliases for IRAK2 Gene

Aliases for IRAK2 Gene

  • Interleukin-1 Receptor-Associated Kinase 2 2 3
  • IRAK-2 3 4
  • Interleukin-1 Receptor-Associated Kinase-Like 2 3
  • Interleukin-1 Receptor Associated Kinase-2 3

External Ids for IRAK2 Gene

Previous GeneCards Identifiers for IRAK2 Gene

  • GC03P010135
  • GC03P010198
  • GC03P010181
  • GC03P010206
  • GC03P010142

Summaries for IRAK2 Gene

Entrez Gene Summary for IRAK2 Gene

  • IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRAK2 Gene

IRAK2 (Interleukin-1 Receptor-Associated Kinase 2) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK4.

UniProtKB/Swiss-Prot for IRAK2 Gene

  • Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Gene Wiki entry for IRAK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK2 Gene

Genomics for IRAK2 Gene

Regulatory Elements for IRAK2 Gene

Genomic Location for IRAK2 Gene

10,164,865 bp from pter
10,243,743 bp from pter
78,879 bases
Plus strand

Genomic View for IRAK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK2 Gene

Proteins for IRAK2 Gene

  • Protein details for IRAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor-associated kinase-like 2
    Protein Accession:
    Secondary Accessions:
    • B4DQZ6
    • Q08AG6
    • Q5K546

    Protein attributes for IRAK2 Gene

    625 amino acids
    Molecular mass:
    69433 Da
    Quaternary structure:
    • Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

    Three dimensional structures from OCA and Proteopedia for IRAK2 Gene

neXtProt entry for IRAK2 Gene

Proteomics data for IRAK2 Gene at MOPED

Post-translational modifications for IRAK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRAK2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IRAK2 Gene

Domains for IRAK2 Gene

Protein Domains for IRAK2 Gene

Suggested Antigen Peptide Sequences for IRAK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43187
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with IRAK2: view

Function for IRAK2 Gene

Molecular function for IRAK2 Gene

UniProtKB/Swiss-Prot Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Gene Ontology (GO) - Molecular Function for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11544529
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with IRAK2: view
genes like me logo Genes that share phenotypes with IRAK2: view

Animal Models for IRAK2 Gene

MGI Knock Outs for IRAK2:

miRNA for IRAK2 Gene

miRTarBase miRNAs that target IRAK2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IRAK2 Gene

Localization for IRAK2 Gene

Subcellular locations from

Jensen Localization Image for IRAK2 Gene COMPARTMENTS Subcellular localization image for IRAK2 gene
Compartment Confidence
cytosol 4
endosome 4
plasma membrane 4
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with IRAK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRAK2 Gene

Pathways for IRAK2 Gene

genes like me logo Genes that share pathways with IRAK2: view

Gene Ontology (GO) - Biological Process for IRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0001959 regulation of cytokine-mediated signaling pathway IMP 10383454
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 10383454
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IRAK2: view

Compounds for IRAK2 Gene

(2) HMDB Compounds for IRAK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with IRAK2: view

Transcripts for IRAK2 Gene

mRNA/cDNA for IRAK2 Gene

Unigene Clusters for IRAK2 Gene

Interleukin-1 receptor-associated kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK2 Gene

No ASD Table

Relevant External Links for IRAK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRAK2 Gene

mRNA expression in normal human tissues for IRAK2 Gene

mRNA differential expression in normal tissues according to GTEx for IRAK2 Gene

This gene is overexpressed in Muscle - Skeletal (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IRAK2 Gene

SOURCE GeneReport for Unigene cluster for IRAK2 Gene Hs.449207

mRNA Expression by UniProt/SwissProt for IRAK2 Gene

Tissue specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
genes like me logo Genes that share expressions with IRAK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IRAK2 Gene

Orthologs for IRAK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRAK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRAK2 35
  • 97.96 (n)
  • 97.19 (a)
IRAK2 36
  • 99 (a)
(Bos Taurus)
Mammalia IRAK2 35
  • 84.81 (n)
  • 79.07 (a)
IRAK2 36
  • 79 (a)
(Canis familiaris)
Mammalia IRAK2 35
  • 85.39 (n)
  • 81.28 (a)
VHL 36
  • 81 (a)
(Mus musculus)
Mammalia Irak2 35
  • 76.34 (n)
  • 70.16 (a)
Irak2 16
Irak2 36
  • 70 (a)
(Monodelphis domestica)
Mammalia IRAK2 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia IRAK2 36
  • 50 (a)
(Rattus norvegicus)
Mammalia Irak2 35
  • 77.05 (n)
  • 71.43 (a)
(Gallus gallus)
Aves IRAK2 35
  • 58.08 (n)
  • 50 (a)
IRAK2 36
  • 39 (a)
(Anolis carolinensis)
Reptilia IRAK2 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia irak2 35
  • 47.31 (n)
  • 39.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta pll 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea pik-1 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for IRAK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IRAK2 Gene

Gene Tree for IRAK2 (if available)
Gene Tree for IRAK2 (if available)

Paralogs for IRAK2 Gene

Paralogs for IRAK2 Gene

genes like me logo Genes that share paralogs with IRAK2: view

Variants for IRAK2 Gene

Sequence variations from dbSNP and Humsavar for IRAK2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs155265 -- 10,188,924(-) caata(C/T)tttgg intron-variant
rs155266 -- 10,189,044(-) gctcc(A/T)tgagg intron-variant
rs155582 -- 10,190,296(+) ttttt(G/T)gtgag intron-variant
rs155583 -- 10,191,840(-) CTGCC(A/G)TAATA intron-variant
rs155584 -- 10,192,484(-) TTATG(C/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRAK2 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
esv2664847 CNV Deletion 23128226
esv2724896 CNV Deletion 23290073
esv2674709 CNV Deletion 23128226
esv6737 CNV Loss 19470904
nsv821984 CNV Loss 20364138
nsv436398 CNV Deletion 17901297
esv23190 CNV Loss 19812545
dgv848e199 CNV Deletion 23128226
nsv437322 CNV Loss 16327808
nsv524674 CNV Loss 19592680
nsv522516 CNV Gain 19592680
nsv523288 CNV Loss 19592680
nsv876526 CNV Loss 21882294
esv2662021 CNV Deletion 23128226
nsv821985 CNV Loss 20364138
esv1307821 CNV Insertion 17803354

Relevant External Links for IRAK2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRAK2 Gene

Disorders for IRAK2 Gene

(2) Novoseek inferred disease relationships for IRAK2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 34.2 1
tumors 10.5 1

Relevant External Links for IRAK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IRAK2: view

No data available for UniProtKB/Swiss-Prot for IRAK2 Gene

Publications for IRAK2 Gene

  1. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (PMID: 9374458) Muzio M. … Dixit V.M. (Science 1997) 2 3 4 23
  2. IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PMID: 10383454) Wesche H. … Cao Z. (J. Biol. Chem. 1999) 3 4 23
  3. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. (PMID: 12721283) Bin L.-H. … Shu H.-B. (J. Biol. Chem. 2003) 3 23
  4. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (PMID: 11544529) Fitzgerald K.A. … O'Neill L.A.J. (Nature 2001) 3 23
  5. Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. (PMID: 11744690) McDermott E.P. … O'Neill L.A. (J. Biol. Chem. 2002) 3 23

Products for IRAK2 Gene

  • Addgene plasmids for IRAK2

Sources for IRAK2 Gene

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