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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRAK2 Gene

protein-coding   GIFtS: 62
GCID: GC03P010206

Interleukin-1 Receptor-Associated Kinase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin-1 Receptor-Associated Kinase 21 2
IRAK-22 3
Interleukin-1 Receptor Associated Kinase-22
Interleukin-1 Receptor-Associated Kinase-Like 22

External Ids:    HGNC: 61131   Entrez Gene: 36562   Ensembl: ENSG000001340707   OMIM: 6033045   UniProtKB: O431873   

Export aliases for IRAK2 gene to outside databases

Previous GC identifers: GC03P010135 GC03P010198 GC03P010181 GC03P010142


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRAK2 Gene:
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that
become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in
the IL1-induced upregulation of NF-kappaB. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRAK2 Gene: 
IRAK2 (interleukin-1 receptor-associated kinase 2) is a protein-coding gene. Diseases associated with IRAK2 include vaccinia, and pituitary adenoma, and among its related super-pathways are TLR-TRIF Pathway and IL-1 beta-dependent CFTR expression. GO annotations related to this gene include protein kinase activity and protein homodimerization activity. An important paralog of this gene is IRAK1.

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades
leading to transcriptional up-regulation and mRNA stabilization

Gene Wiki entry for IRAK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRAK2 gene promoter:
         AP-1   ATF-2   MyoD   NF-kappaB   C/EBPalpha   NF-kappaB2   NF-kappaB1   Hlf   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRAK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRAK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.2

IRAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P010206:  view genomic region     (about GC identifiers)

Start:
10,206,549 bp from pter      End:
10,285,427 bp from pter
Size:
78,879 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187 (See protein sequence)
Recommended Name: Interleukin-1 receptor-associated kinase-like 2  
Size: 625 amino acids; 69433 Da
Subunit: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates
from the IL-1 receptor following the binding of PELI1
Caution: Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This
enzyme has been shown to be catalytically inactive
1 PDB 3D structure from and Proteopedia for IRAK2:
3MOP (3D)    
Secondary accessions: B4DQZ6 Q08AG6 Q5K546

Explore the universe of human proteins at neXtProt for IRAK2: NX_O43187

Explore proteomics data for IRAK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43187

  • IRAK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRAK2 Protein Expression
    REFSEQ proteins: NP_001561.3  
    ENSEMBL proteins: 
     ENSP00000256458  
    Reactome Protein details: O43187
    Human Recombinant Protein Products for IRAK2: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IRAK2
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    Novus Biologicals IRAK2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRAK2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA12493773
    GO:0010008endosome membrane TAS--

    IRAK2 for ontologies           About GeneDecksing



    IRAK2 Antibody Products: 
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    Assay Products for IRAK2: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IRAK2 
    Cloud-Clone Corp. CLIAs for IRAK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: interleukin-1 receptor-associated kinase 2 
    Interleukin-1 receptor-associated kinase (IRAK) family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry O43187

    ProtoNet protein and cluster: O43187

    UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    IRAK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRAK2_HUMAN, O43187
    Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades
    leading to transcriptional up-regulation and mRNA stabilization

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11544529
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    IRAK2 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for IRAK2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Decreased mitotic index  Decreased substrate adherent c  Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Irak2):
     homeostasis/metabolism  immune system  mortality/aging 

    IRAK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IRAK2: Irak2tm1Jth Irak2tm1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRAK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRAK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRAK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRAK2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRAK2:
    hsa-mir-146a (MIRT000304)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK2
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK2 (see all 32):
    hsa-miR-320a hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-875-3p hsa-miR-15a hsa-miR-503 hsa-miR-302e
    SwitchGear 3'UTR luciferase reporter plasmidIRAK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IRAK2
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: IRAK2 (NM_001570)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK2
    Sirion Biotech Customized lentivirus for stable overexpression of IRAK2 
                         Customized lentivirus expression plasmids for stable overexpression of IRAK2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IRAK2 About   (see all 26)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    2Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL-1 beta-dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    IL-1 Signaling Pathway0.32
    3Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    414-3-3 Induced Apoptosis
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37
    5TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for IRAK2
        Transcription NF-kB signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Immune response MIF in innate immunity response

    1 R&D Systems Pathway for IRAK2
        Toll-Like receptor Signaling Pathways

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRAK2 (see all 12)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway

    2 Cell Signaling Technology (CST) Pathways for IRAK2
        Lymphocyte Signaling
    NF-kappaB Signaling

    5/9 GeneGo (Thomson Reuters) Pathways for IRAK2 (see all 9)
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription NF-kB signaling pathway

    1 BioSystems Pathway for IRAK2
        IL-1 Signaling Pathway

    5/31        Reactome Pathways for IRAK2 (see all 31)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    IRAK2 mediated activation of TAK1 complex
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    3         Kegg Pathways  (Kegg details for IRAK2):
        Apoptosis
    Neurotrophin signaling pathway
    Tuberculosis


    IRAK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRAK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for IRAK2 (O431871, 2, 3 ENSP000002564584) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K31, 2, 3EBI-447733,EBI-359276 MINT-50485 I2D: score=6 
    TIRAPP587531, 3, ENSP000003764454EBI-447733,EBI-528644 I2D: score=4 STRING: ENSP00000376445
    ZC3H12AQ5D1E81, 3EBI-447733,EBI-747793 I2D: score=1 
    IRAK3Q9Y6161, 2, 3, ENSP000002612334EBI-447733,EBI-447690 MINT-50489 I2D: score=4 STRING: ENSP00000261233
    IRAK1P516171, 2, 3, ENSP000003589974EBI-447733,EBI-358664 MINT-50487 I2D: score=5 STRING: ENSP00000358997
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0001959regulation of cytokine-mediated signaling pathway IMP10383454
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS10383454
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    IRAK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRAK2

    2 HMDB Compounds for IRAK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about IRAK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRAK2 gene: 
    NM_001570.3  

    Unigene Cluster for IRAK2:

    Interleukin-1 receptor-associated kinase 2
    Hs.449207  [show with all ESTs]
    Unigene Representative Sequence: NM_001570
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000256458(uc003bve.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK2
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK2 (see all 32):
    hsa-miR-320a hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-875-3p hsa-miR-15a hsa-miR-503 hsa-miR-302e
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK2
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK2

    Additional mRNA sequence: 

    AF026273.1 AJ496794.1 AK299033.1 AK312841.1 BC125184.1 

    3 DOTS entries:

    DT.40123269  DT.102826610  DT.75173395 

    24/31 AceView cDNA sequences (see all 31):

    AW848229 AW848508 AI891138 BM990622 AI246590 NM_001570 AF026273 BI760724 
    CD612045 BX957043 AL567543 BG288146 BX369510 AL556221 AA876147 AW848443 
    CD612050 AL538890 BG682610 CD612048 BG287255 BX329231 CD612044 BX369509 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRAK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGAAAGA
    IRAK2 Expression
    About this image


    See IRAK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRAK2

    SOURCE GeneReport for Unigene cluster: Hs.449207

    UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187
    Tissue specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and
    peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IRAK2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IRAK2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irak21 , 5 interleukin-1 receptor-associated kinase 21, 5 76.24(n)1
    70.16(a)1
      6 (52.82 cM)5
    1089601  NM_172161.41  NP_751893.31 
     1136384675 
    chicken
    (Gallus gallus)
    Aves IRAK21 interleukin-1 receptor-associated kinase 2 57.96(n)
    49.25(a)
      416118  NM_001030605.1  NP_001025776.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRAK26
    interleukin-1 receptor-associated kinase 2
    38(a)
    1 ↔ 1
    GL343273.1(894473-937329)
    fruit fly
    (Drosophila melanogaster)
    Insecta pll6
    pelle
    23(a)
    1 → many
    3R(23076853-23078902)
    worm
    (Caenorhabditis elegans)
    Secernentea pik-16
    Protein PIK-1, isoform a
    20(a)
    1 → many
    IV(13416792-13421525)


    ENSEMBL Gene Tree for IRAK2 (if available)
    TreeFam Gene Tree for IRAK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRAK2 gene
    IRAK12  IRAK42  IRAK32  

    IRAK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2098 SNPs in IRAK2 are shown (see all 2098)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413464
    A lung adenocarcinoma sample4--see VAR_0413462 S L mis40--------
    VAR_0413474
    A lung adenocarcinoma sample4--see VAR_0413472 P T mis40--------
    rs3736863081,2
    C--10143017(+) GGGGG-/GTGTGTG 1 -- int10--------
    rs670635631,2
    C,F--10192532(-) AATTT-/A/AA/T
            
    TTTTT
    1 -- int12NA 4
    rs582433201,2
    C--10204588(+) TATAT-/ATATAT
            
    GTATA
    1 -- us2k11Minor allele frequency- ATATAT:0.00NA 2
    rs98528201,2
    C--10204655(+) ggtctC/Gactct 1 -- us2k10--------
    rs1423250551,2
    --10204784(+) TGCCTA/GGCTAA 1 -- us2k10--------
    rs1925758851,2
    --10204806(+) ACAGGA/GTCTTG 1 -- us2k10--------
    rs114658461,2
    C,F--10204901(+) GAGCCG/ACNGCA 1 -- us2k13Minor allele frequency- A:0.01NA EU 86
    rs1838251,2
    C,F--10204903(+) gccgcC/Tgcacc 1 -- us2k18Minor allele frequency- T:0.06NA EU EA 332

    HapMap Linkage Disequilibrium report for IRAK2 (10206549 - 10285427 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for IRAK2 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv848e199CNV Deletion23128226
    esv2724896CNV Deletion23290073
    dgv809e201CNV Deletion23290073
    nsv436362CNV Deletion17901297
    esv2664847CNV Deletion23128226
    esv2674709CNV Deletion23128226
    nsv436398CNV Deletion17901297
    esv2662021CNV Deletion23128226
    esv1307821CNV Insertion17803354
    nsv436869CNV Insertion17901297

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603304    OMIM disorders: --

    10 diseases for IRAK2:    About MalaCards
    vaccinia    pituitary adenoma    meningioma    adenoma
    chronic lymphocytic leukemia    alzheimer's disease    tuberculosis    leukemia
    endotheliitis    prostatitis


    IRAK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for IRAK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 34.2 1 18070880 (1)
    tumors 10.5 1 18070880 (1)

    Genetic Association Database (GAD): IRAK2
    Human Genome Epidemiology (HuGE) Navigator: IRAK2 (18 documents)

    Export disorders for IRAK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRAK2 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with IRAK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (PubMed id 9374458)1, 2, 3, 9 Muzio M.... Dixit V.M. (1997)
    2. IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PubMed id 10383454)1, 2, 9 Wesche H.... Cao Z. (1999)
    3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    4. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. (PubMed id 20485341)1, 2 Lin S.C....Wu H. (2010)
    8. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3656 HGNC: 6113 AceView: IRAK2 Ensembl:ENSG00000134070 euGenes: HUgn3656
    ECgene: IRAK2 Kegg: 3656 H-InvDB: IRAK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRAK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRAK2 gene:
    Search GeneIP for patents involving IRAK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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