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IRAK2 Gene

protein-coding   GIFtS: 61
GCID: GC03P010206

Interleukin-1 Receptor-Associated Kinase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin-1 Receptor-Associated Kinase 21 2
IRAK-22 3
Interleukin-1 Receptor Associated Kinase-22
Interleukin-1 Receptor-Associated Kinase-Like 22

External Ids:    HGNC: 61131   Entrez Gene: 36562   Ensembl: ENSG000001340707   OMIM: 6033045   UniProtKB: O431873   

Export aliases for IRAK2 gene to outside databases

Previous GC identifers: GC03P010135 GC03P010198 GC03P010181 GC03P010142


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRAK2 Gene:
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that
become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in
the IL1-induced upregulation of NF-kappaB. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRAK2 Gene:
IRAK2 (interleukin-1 receptor-associated kinase 2) is a protein-coding gene. Diseases associated with IRAK2 include von hippel-lindau disease, and vaccinia. GO annotations related to this gene include protein kinase activity and protein homodimerization activity. An important paralog of this gene is IRAK1.

UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades
leading to transcriptional up-regulation and mRNA stabilization

Gene Wiki entry for IRAK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRAK2 gene promoter:
         AP-1   ATF-2   MyoD   NF-kappaB   C/EBPalpha   NF-kappaB2   NF-kappaB1   Hlf   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRAK2 promoter sequence
   Search Chromatin IP Primers for IRAK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRAK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.2

IRAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P010206:  view genomic region     (about GC identifiers)

Start:
10,206,549 bp from pter      End:
10,285,427 bp from pter
Size:
78,879 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187 (See protein sequence)
Recommended Name: Interleukin-1 receptor-associated kinase-like 2  
Size: 625 amino acids; 69433 Da
Subunit: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates
from the IL-1 receptor following the binding of PELI1
Caution: Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This
enzyme has been shown to be catalytically inactive
1 PDB 3D structure from and Proteopedia for IRAK2:
3MOP (3D)    
Secondary accessions: B4DQZ6 Q08AG6 Q5K546

Explore the universe of human proteins at neXtProt for IRAK2: NX_O43187

Explore proteomics data for IRAK2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRAK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001561.3  
    ENSEMBL proteins: 
     ENSP00000256458  
    Reactome Protein details: O43187

    IRAK2 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IRAK2
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    Novus Biologicals IRAK2 Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRAK2

    IRAK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRAK2
    R&D Systems Antibodies for IRAK2
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    IRAK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IRAK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRAK2
    Cloud-Clone Corp. CLIAs for IRAK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: interleukin-1 receptor-associated kinase 2
    Interleukin-1 receptor-associated kinase (IRAK) family

    4 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry O43187

    ProtoNet protein and cluster: O43187

    UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    IRAK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRAK2_HUMAN, O43187
    Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades
    leading to transcriptional up-regulation and mRNA stabilization

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11544529
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    IRAK2 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for IRAK2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Decreased mitotic index  Decreased substrate adherent c  Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Irak2):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    IRAK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IRAK2: Irak2tm1Jth Irak2tm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRAK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRAK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRAK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRAK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRAK2:
    hsa-mir-335-5p (MIRT017238), hsa-mir-146a-5p (MIRT000304)

    Block miRNA regulation of human, mouse, rat IRAK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRAK2 (see all 32):
    hsa-miR-320a hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-875-3p hsa-miR-15a hsa-miR-503 hsa-miR-302e
    SwitchGear 3'UTR luciferase reporter plasmidIRAK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRAK2
    Predesigned siRNA for gene silencing in human, mouse, rat IRAK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRAK2

    Clone
    Products:
         
    OriGene clones in human, mouse for IRAK2 (see all 8)
    OriGene ORF clones in mouse, rat for IRAK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRAK2 (NM_001570)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IRAK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IRAK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    plasma membrane4
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--

    IRAK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRAK2 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    2Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL 1 beta dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    IL-1 Family Signaling Pathways0.44
    4Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL-1 Signaling Pathway0.00
    5Apoptosis (KEGG)
    14-3-3 Induced Apoptosis0.37
    Apoptosis0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IRAK2
        IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IRAK2 (see all 12)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway

    2 Cell Signaling Technology (CST) Pathways for IRAK2
        Lymphocyte Signaling
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for IRAK2 (see all 9)
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription NF-kB signaling pathway

    1 BioSystems Pathway for IRAK2
        IL-1 Signaling Pathway

    Selected Reactome Pathways for IRAK2 (see all 11)
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    IRAK2 mediated activation of TAK1 complex
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    MyD88 dependent cascade initiated on endosome
    Interleukin-1 signaling


    3 Kegg Pathways  (Kegg details for IRAK2):
        Apoptosis
    Neurotrophin signaling pathway
    Tuberculosis


    IRAK2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRAK2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRAK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRAK2 (O431871, 2, 3 ENSP000002564584) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIRAPP587531, 3, ENSP000003764454EBI-447733,EBI-528644 I2D: score=4 STRING: ENSP00000376445
    TRAF6Q9Y4K32, 3MINT-50485 I2D: score=6 
    ZC3H12AQ5D1E81, 3EBI-447733,EBI-747793 I2D: score=1 
    MYD88Q998362, 3, ENSP000003796254MINT-50482 I2D: score=5 STRING: ENSP00000379625
    IRAK3Q9Y6162, 3, ENSP000002612334MINT-50489 I2D: score=4 STRING: ENSP00000261233
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    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0001959regulation of cytokine-mediated signaling pathway IMP10383454
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS10383454
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    IRAK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRAK2

    2 HMDB Compounds for IRAK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IRAK2 gene: 
    NM_001570.3  

    Unigene Cluster for IRAK2:

    Interleukin-1 receptor-associated kinase 2
    Hs.449207  [show with all ESTs]
    Unigene Representative Sequence: NM_001570
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000256458(uc003bve.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IRAK2 (see all 32):
    hsa-miR-320a hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-875-3p hsa-miR-15a hsa-miR-503 hsa-miR-302e
    SwitchGear 3'UTR luciferase reporter plasmidIRAK2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRAK2 (NM_001570)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRAK2
      QuantiTect SYBR Green Assays in human, mouse, rat IRAK2
      QuantiFast Probe-based Assays in human, mouse, rat IRAK2

    Additional mRNA sequence: 

    AF026273.1 AJ496794.1 AK299033.1 AK312841.1 BC125184.1 

    3 DOTS entries:

    DT.40123269  DT.102826610  DT.75173395 

    Selected AceView cDNA sequences (see all 31):

    AI891138 AW848508 AW848229 AW848443 AL538890 CD612048 CD612045 BG682610 
    BM990622 BX329231 BX369509 BM976377 AI246590 AF026273 BI760724 BG431557 
    BG259609 BG287255 AA876147 AL567543 BG288146 CD612044 BX957043 AL556221 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRAK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGAAAGA
    IRAK2 Expression
    About this image

    IRAK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRAK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449207

    UniProtKB/Swiss-Prot: IRAK2_HUMAN, O43187
    Tissue specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and
    peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRAK2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat IRAK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IRAK2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irak21 , 5 interleukin-1 receptor-associated kinase 21, 5 76.34(n)1
    70.16(a)1
      6 (52.82 cM)5
    1089601  NM_172161.41  NP_751893.31 
     1136384675 
    chicken
    (Gallus gallus)
    Aves IRAK21 interleukin-1 receptor-associated kinase 2 58.08(n)
    50(a)
      416118  NM_001030605.1  NP_001025776.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRAK26
    interleukin-1 receptor-associated kinase 2
    39(a)
    1 ↔ 1
    GL343273.1(894473-937329)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia irak21 interleukin-1 receptor-associated kinase 2 47.31(n)
    39.28(a)
      493227  NM_001007500.1  NP_001007501.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pll6
    pelle
    25(a)
    1 → many
    3R(23076853-23078902)
    worm
    (Caenorhabditis elegans)
    Secernentea pik-16
    Protein PIK-1, isoform b (pik-1) mRNA, complete cd...
    22(a)
    1 → many
    IV(13416041-13421525) WBGene00004029


    ENSEMBL Gene Tree for IRAK2 (if available)
    TreeFam Gene Tree for IRAK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRAK2 gene
    IRAK12  IRAK42  IRAK32  

    IRAK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRAK2 (see all 2098)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413464
    A lung adenocarcinoma sample4--see VAR_0413462 S L mis40--------
    VAR_0413474
    A lung adenocarcinoma sample4--see VAR_0413472 P T mis40--------
    rs3736863081,2
    C--10143017(+) GGGGG-/GTGTGTG 1 -- int10--------
    rs670635631,2
    C,F--10192532(-) AATTT-/A/AA/T
            
    TTTTT
    1 -- int12NA 4
    rs582433201,2
    C--10204588(+) TATAT-/ATATAT
            
    GTATA
    1 -- us2k11Minor allele frequency- ATATAT:0.00NA 2
    rs98528201,2
    C--10204655(+) ggtctC/Gactct 1 -- us2k10--------
    rs1423250551,2
    --10204784(+) TGCCTA/GGCTAA 1 -- us2k10--------
    rs1925758851,2
    --10204806(+) ACAGGA/GTCTTG 1 -- us2k10--------
    rs114658461,2
    C,F--10204901(+) GAGCCG/ACNGCA 1 -- us2k13Minor allele frequency- A:0.01NA EU 86
    rs1838251,2
    C,F--10204903(+) gccgcC/Tgcacc 1 -- us2k18Minor allele frequency- T:0.06NA EU EA 332

    HapMap Linkage Disequilibrium report for IRAK2 (10206549 - 10285427 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IRAK2 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv848e199CNV Deletion23128226
    esv2724896CNV Deletion23290073
    dgv809e201CNV Deletion23290073
    nsv436362CNV Deletion17901297
    esv2664847CNV Deletion23128226
    esv2674709CNV Deletion23128226
    nsv436398CNV Deletion17901297
    esv2662021CNV Deletion23128226
    esv1307821CNV Insertion17803354
    nsv436869CNV Insertion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRAK2
    DNA2.0 Custom Variant and Variant Library Synthesis for IRAK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603304    OMIM disorders: --

    14 diseases for IRAK2:    About MalaCards
    von hippel-lindau disease    vaccinia    pituitary adenoma    childhood leukemia
    osteoporosis    meningioma    adenoma    chronic lymphocytic leukemia
    tuberculosis    alzheimer's disease    endotheliitis    leukemia
    prostate cancer    prostatitis


    IRAK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for IRAK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 34.2 1 18070880 (1)
    tumors 10.5 1 18070880 (1)

    Genetic Association Database (GAD): IRAK2
    Human Genome Epidemiology (HuGE) Navigator: IRAK2 (18 documents)

    Export disorders for IRAK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRAK2 gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with IRAK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. (PubMed id 9374458)1, 2, 3, 9 Muzio M.... Dixit V.M. (Science 1997)
    2. IRAK-M is a novel member of the Pelle/interleukin-1 receptor- associated kinase (IRAK) family. (PubMed id 10383454)1, 2, 9 Wesche H.... Cao Z. (J. Biol. Chem. 1999)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. (PubMed id 20485341)1, 2 Lin S.-C.... Wu H. (Nature 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3656 HGNC: 6113 AceView: IRAK2 Ensembl:ENSG00000134070 euGenes: HUgn3656
    ECgene: IRAK2 Kegg: 3656 H-InvDB: IRAK2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IRAK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IRAK2 gene:
    Search GeneIP for patents involving IRAK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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