Aliases for IRAK2 Gene
External Ids for IRAK2 Gene
Previous GeneCards Identifiers for IRAK2 Gene
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRAK2 Gene
IRAK2 (Interleukin 1 Receptor Associated Kinase 2) is a Protein Coding gene. Diseases associated with IRAK2 include Lymphocytic Colitis. Among its related pathways are Activated TLR4 signalling and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is IRAK1.
UniProtKB/Swiss-Prot for IRAK2 Gene
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
The IRAKs (Interleukin-1 receptor-associated kinases) are serine-threonine kinases, EC 220.127.116.11, that are essential regulators of IL-1R and TLR-mediated signaling. Four IRAK isoforms have been identified to date, IRAK1, IRAK2, IRAK3 (IRAK-M) and IRAK4.