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Aliases for IRAK1BP1 Gene

Aliases for IRAK1BP1 Gene

  • Interleukin 1 Receptor Associated Kinase 1 Binding Protein 1 2 3 5
  • IRAK1-Binding Protein 1 3 4
  • Interleukin-1 Receptor-Associated Kinase 1-Binding Protein 1 3
  • ActA Binding Protein 3 3
  • AIP70 3
  • SIMPL 3

External Ids for IRAK1BP1 Gene

Previous GeneCards Identifiers for IRAK1BP1 Gene

  • GC06P079527
  • GC06P079572
  • GC06P079633
  • GC06P076770
  • GC06P079577

Summaries for IRAK1BP1 Gene

GeneCards Summary for IRAK1BP1 Gene

IRAK1BP1 (Interleukin 1 Receptor Associated Kinase 1 Binding Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IRAK1BP1 Gene

  • Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK1BP1 Gene

Genomics for IRAK1BP1 Gene

Regulatory Elements for IRAK1BP1 Gene

Enhancers for IRAK1BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G078908 1 Ensembl ENCODE 44.6 +43.7 43734 3.8 GATAD2A L3MBTL2 USF2 CBX2 DPF2 RBBP5 REST ARID1B JUND RAD51 IRAK1BP1 PIR49199 GC06M078960 TRF-GAA8-1
GH06G078866 1.1 ENCODE 31.5 +0.5 479 2.4 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 IRAK1BP1 PIR49199
GH06G079075 1.1 ENCODE 20.6 +210.6 210584 4.9 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CBX5 IRAK1BP1 GC06P079077 LOC100419073
GH06G078887 0.5 FANTOM5 33.7 +20.7 20708 0.1 ZNF366 ZNF512 ATF2 IRAK1BP1 PIR49199
GH06G079043 0.3 FANTOM5 26.9 +176.6 176610 0.3 IRAK1BP1 GC06M079068 GC06M079003
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRAK1BP1 on UCSC Golden Path with GeneCards custom track

Promoters for IRAK1BP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199154 516 2000 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for IRAK1BP1 Gene

Chromosome:
6
Start:
78,867,085 bp from pter
End:
78,946,440 bp from pter
Size:
79,356 bases
Orientation:
Plus strand

Genomic View for IRAK1BP1 Gene

Genes around IRAK1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRAK1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRAK1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK1BP1 Gene

Proteins for IRAK1BP1 Gene

  • Protein details for IRAK1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVH5-IKBP1_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase 1-binding protein 1
    Protein Accession:
    Q5VVH5

    Protein attributes for IRAK1BP1 Gene

    Size:
    260 amino acids
    Molecular mass:
    29106 Da
    Quaternary structure:
    • Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity).

neXtProt entry for IRAK1BP1 Gene

Post-translational modifications for IRAK1BP1 Gene

  • Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IRAK1BP1 Gene

Domains & Families for IRAK1BP1 Gene

Protein Domains for IRAK1BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IRAK1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VVH5

UniProtKB/Swiss-Prot:

IKBP1_HUMAN :
  • The intrinsically disordered region interacts with HSPA1 and HSPA8.
  • Belongs to the IRAK1BP1 family.
Domain:
  • The intrinsically disordered region interacts with HSPA1 and HSPA8.
Family:
  • Belongs to the IRAK1BP1 family.
genes like me logo Genes that share domains with IRAK1BP1: view

No data available for Gene Families for IRAK1BP1 Gene

Function for IRAK1BP1 Gene

Molecular function for IRAK1BP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

Gene Ontology (GO) - Molecular Function for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IRAK1BP1: view
genes like me logo Genes that share phenotypes with IRAK1BP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRAK1BP1 Gene

Localization for IRAK1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRAK1BP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRAK1BP1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IRAK1BP1: view

Pathways & Interactions for IRAK1BP1 Gene

SuperPathways for IRAK1BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA,ISS --
genes like me logo Genes that share ontologies with IRAK1BP1: view

No data available for Pathways by source and SIGNOR curated interactions for IRAK1BP1 Gene

Transcripts for IRAK1BP1 Gene

Unigene Clusters for IRAK1BP1 Gene

Interleukin-1 receptor-associated kinase 1 binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1BP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for IRAK1BP1 Gene

GeneLoc Exon Structure for
IRAK1BP1
ECgene alternative splicing isoforms for
IRAK1BP1

Expression for IRAK1BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRAK1BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRAK1BP1 Gene:

IRAK1BP1

SOURCE GeneReport for Unigene cluster for IRAK1BP1 Gene:

Hs.656212

Evidence on tissue expression from TISSUES for IRAK1BP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IRAK1BP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRAK1BP1 Gene

Orthologs for IRAK1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRAK1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRAK1BP1 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia IRAK1BP1 34 35
  • 89.87 (n)
cow
(Bos Taurus)
Mammalia IRAK1BP1 34 35
  • 89.09 (n)
mouse
(Mus musculus)
Mammalia Irak1bp1 34 16 35
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Irak1bp1 34
  • 81.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IRAK1BP1 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRAK1BP1 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRAK1BP1 34 35
  • 65.86 (n)
lizard
(Anolis carolinensis)
Reptilia IRAK1BP1 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irak1bp1 34
  • 68.53 (n)
Str.9202 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6893 34
zebrafish
(Danio rerio)
Actinopterygii irak1bp1 34 35
  • 49.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3890 35
  • 34 (a)
OneToOne
Species where no ortholog for IRAK1BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRAK1BP1 Gene

ENSEMBL:
Gene Tree for IRAK1BP1 (if available)
TreeFam:
Gene Tree for IRAK1BP1 (if available)

Paralogs for IRAK1BP1 Gene

No data available for Paralogs for IRAK1BP1 Gene

Variants for IRAK1BP1 Gene

Sequence variations from dbSNP and Humsavar for IRAK1BP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000006445 -- 78,892,209(+) TAACA(A/C/G)ACTCT intron-variant
rs1000025837 -- 78,870,557(+) CAGCT(A/G)TGGTA intron-variant
rs1000044372 -- 78,940,322(+) TATCA(C/T)TAGGA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000047406 -- 78,969,755(+) TTTCT(C/G)AATTA intron-variant, downstream-variant-500B
rs1000092026 -- 78,924,996(+) AAAAA(G/T)GATGA intron-variant

Variation tolerance for IRAK1BP1 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRAK1BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRAK1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IRAK1BP1 Gene

Disorders for IRAK1BP1 Gene

Relevant External Links for IRAK1BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRAK1BP1

No disorders were found for IRAK1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRAK1BP1 Gene

Publications for IRAK1BP1 Gene

  1. SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. (PMID: 11096118) Vig E. … Harrington M.A. (J. Biol. Chem. 2001) 2 3 4 64
  2. 1Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA. (PMID: 25943894) Krishnan G. … Chatterjee N. (Sci Rep 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. (PMID: 24165912) He J. … Gu D. (Circ Cardiovasc Genet 2013) 3 64
  5. Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. (PMID: 17079333) Luo Y. … Harrington M.A. (Am. J. Physiol., Cell Physiol. 2007) 3 64

Products for IRAK1BP1 Gene

Sources for IRAK1BP1 Gene

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