IRAK1BP1 Gene
protein-coding GIFtS: 44
GCID: GC06P079577
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interleukin-1 receptor-associated kinase 1 binding protein...
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Aliases
for IRAK1BP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 11 2 | | AIP701 2 | | SIMPL1 2 | | 4921528N06Rik2 | | ActA Binding Protein 32 | | Interleukin-1 Receptor-Associated Kinase 1-Binding Protein 12 |
Export aliases for IRAK1BP1 gene to outside databasesPrevious GC identifers: GC06P079527 GC06P079572 GC06P079633 GC06P076770 |
Summaries
for IRAK1BP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and isrequired for cell survival. Acts by enhancing RELA transcriptional activity (By similarity)
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Genomic Views
for IRAK1BP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRAK1BP1 gene promoter:
HEN1 GATA-3 FOXJ2 (long isoform) Chx10 FOXO1a FOXJ2 E4BP4 GATA-1 GATA-2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRAK1BP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK1BP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14-q15 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q14-q15IRAK1BP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P079577: view genomic region
(about GC identifiers)
Start:
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79,577,189 bp from pter |
End:
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79,608,320 bp from pter |
Size:
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31,132 bases |
Orientation:
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plus strand |
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Proteins
for IRAK1BP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5 (See
protein sequence)Recommended Name: Interleukin-1 receptor-associated kinase 1-binding protein 1 Size: 260 amino acids; 29106 Da
Subunit: Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)Explore the universe of human proteins at neXtProt for IRAK1BP1: NX_Q5VVH5
Post-translational modifications:
Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235,Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VVH5
IRAK1BP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010844.1
ENSEMBL proteins: ENSP00000358956
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IRAK1BP1 for ontologies About GeneDecksing
IRAK1BP1 Antibody Products:
Assay Products for IRAK1BP1: |
Protein
Domains /
Families
for IRAK1BP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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IRAK1BP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VVH5ProtoNet protein and cluster: Q5VVH5 UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5Domain: The intrinsically disordered region interacts with HSPA1 and HSPA8 (By similarity)Similarity: Belongs to the IRAK1BP1 family |
Function
for IRAK1BP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and isrequired for cell survival. Acts by enhancing RELA transcriptional activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1BP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1BP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IRAK1BP1 (NM_001010844) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRAK1BP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1BP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1BP1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
IRAK1BP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IRAK1BP1:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Irak1bp1):
IRAK1BP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IRAK1BP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRAK1BP1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for IRAK1BP1 (Q5VVH53 ENSP000003589564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007249 | I-kappaB kinase/NF-kappaB cascade |
ISS | -- |
IRAK1BP1 for ontologies About GeneDecksing
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Drugs & Compounds
for IRAK1BP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IRAK1BP1
Search CenterWatch for drugs/clinical trials and news about IRAK1BP1 / IKBP1
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Transcripts
for IRAK1BP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRAK1BP1 gene: NM_001010844.1 Unigene Cluster for IRAK1BP1: Interleukin-1 receptor-associated kinase 1 binding protein 1 Hs.656212 [show with all ESTs]Unigene Representative Sequence: AK3090031 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000369940(uc003pim.3 uc010kbg.1 uc003pin.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1BP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1BP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IRAK1BP1 (NM_001010844) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRAK1BP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1BP1 |
Additional cDNA sequence: AK098678.1 AK309003.1 BC112253.1 BC112255.1 11 DOTS entries: DT.97811400 DT.99927665 DT.95227509 DT.95322922 DT.95348514 DT.97858748 DT.103522 DT.121387442 DT.95170404 DT.100675523 DT.75177627 24/61 AceView cDNA sequences (see all 61): BM830836 AL521825 AI379905 AI761886 AI917638 BM127007 BX103697 AA480250 AW450696 AA679673 BF513853 AK098678 BX387112 BQ435042 CB321683 BI562425 BX352843 C20908 AA644376 BI667824 BU561117 AI653019 AI478629 BF002133
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1BP1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
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| SP1: | | | | | | | | | - | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IRAK1BP1
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Expression
for IRAK1BP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRAK1BP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCCCACAT
About this image
See IRAK1BP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRAK1BP1
SOURCE GeneReport for Unigene cluster: Hs.656212
SABiosciences Custom PCR Arrays for IRAK1BP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK1BP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRAK1BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK1BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK1BP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1BP1 |
Orthologs
for IRAK1BP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IRAK1BP1 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for IRAK1BP1 (if available)
TreeFam Gene Tree for IRAK1BP1 (if available) |
Paralogs
for IRAK1BP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IRAK1BP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRAK1BP1 (79577189 - 79608320 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IRAK1BP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRAK1BP1 |
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Disorders
/ Diseases
for IRAK1BP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRAK1BP1 for disorders About GeneDecksing
1  disease for IRAK1BP1: About MalaCardsquadriplegia
Export disorders for IRAK1BP1 gene to outside databases
|
Publications
for IRAK1BP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRAK1BP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IRAK1BP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. (PubMed id 11096118)1, 2, 3 Vig E....Harrington M.A. (2001)
- Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. (PubMed id 17079333)1 Luo Y....Harrington M.A. (2007)
- Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. (PubMed id 15485901)1 Kwon H.J....Harrington M.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for IRAK1BP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IRAK1BP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IRAK1BP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IRAK1BP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IRAK1BP1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IRAK1BP1 gene:
Search GeneIP for patents involving IRAK1BP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IRAK1BP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IRAK1BP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK1BP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK1BP1 | | | OriGene Protein Over-expression Lysate for IRAK1BP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IRAK1BP1 | | OriGene 3'-UTR Clone for IRAK1BP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1BP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1BP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IRAK1BP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IRAK1BP1 | | OriGene Custom Protein Services for IRAK1BP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRAK1BP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRAK1BP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK1BP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK1BP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK1BP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK1BP1 |
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 | | | IRAK1BP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1BP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for IRAK1BP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1BP1 |
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