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Aliases for IRAK1BP1 Gene

Aliases for IRAK1BP1 Gene

  • Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 2 3
  • IRAK1-Binding Protein 1 3 4
  • SIMPL 3 6
  • Interleukin-1 Receptor-Associated Kinase 1-Binding Protein 1 3
  • ActA Binding Protein 3 3
  • AIP70 3

External Ids for IRAK1BP1 Gene

Previous GeneCards Identifiers for IRAK1BP1 Gene

  • GC06P079527
  • GC06P079572
  • GC06P079633
  • GC06P076770
  • GC06P079577

Summaries for IRAK1BP1 Gene

GeneCards Summary for IRAK1BP1 Gene

IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IRAK1BP1 Gene

  • Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK1BP1 Gene

Genomics for IRAK1BP1 Gene

Regulatory Elements for IRAK1BP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRAK1BP1 Gene

78,867,472 bp from pter
78,946,440 bp from pter
78,969 bases
Plus strand

Genomic View for IRAK1BP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRAK1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK1BP1 Gene

Proteins for IRAK1BP1 Gene

  • Protein details for IRAK1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-1 receptor-associated kinase 1-binding protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IRAK1BP1 Gene

    260 amino acids
    Molecular mass:
    29106 Da
    Quaternary structure:
    • Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity).

neXtProt entry for IRAK1BP1 Gene

Proteomics data for IRAK1BP1 Gene at MOPED

Post-translational modifications for IRAK1BP1 Gene

  • Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRAK1BP1 Gene

Antibody Products

No data available for DME Specific Peptides for IRAK1BP1 Gene

Domains for IRAK1BP1 Gene

Protein Domains for IRAK1BP1 Gene


Suggested Antigen Peptide Sequences for IRAK1BP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5VVH5
  • The intrinsically disordered region interacts with HSPA1 and HSPA8.
  • Belongs to the IRAK1BP1 family.
genes like me logo Genes that share domains with IRAK1BP1: view

No data available for Gene Families for IRAK1BP1 Gene

Function for IRAK1BP1 Gene

Molecular function for IRAK1BP1 Gene

UniProtKB/Swiss-Prot Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

Gene Ontology (GO) - Molecular Function for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IRAK1BP1: view

Phenotypes for IRAK1BP1 Gene

MGI mutant phenotypes for IRAK1BP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for IRAK1BP1:
genes like me logo Genes that share phenotypes with IRAK1BP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IRAK1BP1 Gene

Localization for IRAK1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRAK1BP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for IRAK1BP1 Gene COMPARTMENTS Subcellular localization image for IRAK1BP1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IRAK1BP1: view

Pathways for IRAK1BP1 Gene

SuperPathways for IRAK1BP1 Gene

No Data Available

Interacting Proteins for IRAK1BP1 Gene

Gene Ontology (GO) - Biological Process for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling ISS --
genes like me logo Genes that share ontologies with IRAK1BP1: view

No data available for Pathways by source for IRAK1BP1 Gene

Transcripts for IRAK1BP1 Gene

Unigene Clusters for IRAK1BP1 Gene

Interleukin-1 receptor-associated kinase 1 binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRAK1BP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IRAK1BP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1BP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: -

Relevant External Links for IRAK1BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRAK1BP1 Gene

mRNA expression in normal human tissues for IRAK1BP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IRAK1BP1 Gene Hs.656212

genes like me logo Genes that share expressions with IRAK1BP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IRAK1BP1 Gene

Orthologs for IRAK1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRAK1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRAK1BP1 35
  • 99.74 (n)
  • 99.23 (a)
  • 99 (a)
(Bos Taurus)
Mammalia IRAK1BP1 35
  • 89.09 (n)
  • 87.44 (a)
  • 86 (a)
(Canis familiaris)
Mammalia IRAK1BP1 35
  • 89.87 (n)
  • 90 (a)
  • 90 (a)
(Mus musculus)
Mammalia Irak1bp1 35
  • 83.91 (n)
  • 82.63 (a)
Irak1bp1 16
Irak1bp1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia IRAK1BP1 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia IRAK1BP1 36
  • 53 (a)
(Rattus norvegicus)
Mammalia Irak1bp1 35
  • 81.91 (n)
  • 80.23 (a)
(Gallus gallus)
Aves IRAK1BP1 35
  • 65.86 (n)
  • 58.23 (a)
  • 57 (a)
(Anolis carolinensis)
Reptilia IRAK1BP1 36
  • 55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6893 35
tropical clawed frog
(Silurana tropicalis)
Amphibia irak1bp1 35
  • 68.53 (n)
  • 63.45 (a)
Str.9202 35
(Danio rerio)
Actinopterygii irak1bp1 35
  • 49.51 (n)
  • 43.1 (a)
irak1bp1 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3890 36
  • 34 (a)
Species with no ortholog for IRAK1BP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRAK1BP1 Gene

Gene Tree for IRAK1BP1 (if available)
Gene Tree for IRAK1BP1 (if available)

Paralogs for IRAK1BP1 Gene

No data available for Paralogs for IRAK1BP1 Gene

Variants for IRAK1BP1 Gene

Sequence variations from dbSNP and Humsavar for IRAK1BP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1021988 -- 78,882,944(-) ttttg(A/G)aataa intron-variant
rs1354831 -- 78,903,859(+) AGACA(C/T)ATAGT intron-variant
rs1354832 -- 78,904,046(+) GGTAT(C/T)GTGCT intron-variant
rs1911512 -- 78,932,607(+) AGAGA(C/T)GGGGT intron-variant
rs1963080 -- 78,914,821(+) TTTTT(A/G)TTTTG intron-variant

Relevant External Links for IRAK1BP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IRAK1BP1 Gene

Disorders for IRAK1BP1 Gene

No disorders were found for IRAK1BP1 Gene.

No data available for UniProtKB/Swiss-Prot for IRAK1BP1 Gene

Publications for IRAK1BP1 Gene

  1. SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. (PMID: 11096118) Vig E. … Harrington M.A. (J. Biol. Chem. 2001) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. (PMID: 15485901) Kwon H.J. … Harrington M.A. (Mol. Cell. Biol. 2004) 3
  5. Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. (PMID: 17079333) Luo Y. … Harrington M.A. (Am. J. Physiol., Cell Physiol. 2007) 3

Products for IRAK1BP1 Gene

Sources for IRAK1BP1 Gene

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