Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IRAK1BP1 Gene

protein-coding   GIFtS: 45
GCID: GC06P079577

Interleukin-1 Receptor-Associated Kinase 1 Binding Protein...

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 11 2
IRAK1-Binding Protein 12 3
SIMPL2 5
AIP702
ActA Binding Protein 32
Interleukin-1 Receptor-Associated Kinase 1-Binding Protein 12

External Ids:    HGNC: 173681   Entrez Gene: 1347282   Ensembl: ENSG000001462437   OMIM: 6153755   UniProtKB: Q5VVH53   

Export aliases for IRAK1BP1 gene to outside databases

Previous GC identifers: GC06P079527 GC06P079572 GC06P079633 GC06P076770


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IRAK1BP1 Gene:
IRAK1BP1 (interleukin-1 receptor-associated kinase 1 binding protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5
Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is
required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRAK1BP1 gene promoter:
         HEN1   GATA-3   FOXJ2 (long isoform)   Chx10   FOXO1a   FOXJ2   E4BP4   GATA-1   GATA-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRAK1BP1 promoter sequence
   Search Chromatin IP Primers for IRAK1BP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRAK1BP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q14-q15

IRAK1BP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK1BP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P079577:  view genomic region     (about GC identifiers)

Start:
79,577,189 bp from pter      End:
79,656,157 bp from pter
Size:
78,969 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5 (See protein sequence)
Recommended Name: Interleukin-1 receptor-associated kinase 1-binding protein 1  
Size: 260 amino acids; 29106 Da
Subunit: Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity)

Explore the universe of human proteins at neXtProt for IRAK1BP1: NX_Q5VVH5

Explore proteomics data for IRAK1BP1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235,
    Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRAK1BP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010844.1  
    ENSEMBL proteins: 
     ENSP00000358956   ENSP00000475570   ENSP00000475503   ENSP00000475395  

    IRAK1BP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IRAK1BP1
    OriGene Protein Over-expression Lysate for IRAK1BP1
    OriGene MassSpec for IRAK1BP1
    OriGene Custom Protein Services for IRAK1BP1
    GenScript Custom Purified and Recombinant Proteins Services for IRAK1BP1
    Novus Biologicals IRAK1BP1 Protein
    Novus Biologicals IRAK1BP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRAK1BP1

     
    Search eBioscience for Proteins for IRAK1BP1 

     
    antibodies-online proteins for IRAK1BP1 (6 products) 

     
    antibodies-online peptides for IRAK1BP1

    IRAK1BP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IRAK1BP1
    Novus Biologicals IRAK1BP1 Antibodies
    Search for Antibodies for IRAK1BP1 at Abcam
    Cloud-Clone Corp. Antibodies for IRAK1BP1
    Search ThermoFisher Antibodies for IRAK1BP1
    antibodies-online antibodies for IRAK1BP1 (5 products) 

    IRAK1BP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IRAK1BP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRAK1BP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRAK1BP1
    Cloud-Clone Corp. CLIAs for IRAK1BP1
    Search eBioscience for ELISAs for IRAK1BP1 
    antibodies-online kits for IRAK1BP1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007497 DUF541

    Graphical View of Domain Structure for InterPro Entry Q5VVH5

    ProtoNet protein and cluster: Q5VVH5

    UniProtKB/Swiss-Prot: IKBP1_HUMAN, Q5VVH5
    Domain: The intrinsically disordered region interacts with HSPA1 and HSPA8 (By similarity)
    Similarity: Belongs to the IRAK1BP1 family


    Find genes that share domains with IRAK1BP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKBP1_HUMAN, Q5VVH5
    Function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is
    required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IRAK1BP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IRAK1BP1:
     Large cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Irak1bp1):
     no phenotypic analysis 

    Find genes that share phenotypes with IRAK1BP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IRAK1BP1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IRAK1BP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IRAK1BP1:
    hsa-miR-3163 hsa-miR-548c-3p hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidIRAK1BP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRAK1BP1
    Predesigned siRNA for gene silencing in human, mouse, rat IRAK1BP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRAK1BP1

    Clone
    Products:
         
    OriGene clones in human, mouse for IRAK1BP1 (see all 7)
    OriGene ORF clones in mouse, rat for IRAK1BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRAK1BP1 (NM_001010844)
    Sino Biological Human cDNA Clone for IRAK1BP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK1BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1BP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IRAK1BP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IRAK1BP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1BP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IKBP1_HUMAN, Q5VVH5: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with IRAK1BP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IRAK1BP1
    Interactions:

        GeneGlobe Interaction Network for IRAK1BP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for IRAK1BP1 (Q5VVH53 ENSP000003589564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516173, ENSP000003589974I2D: score=5 STRING: ENSP00000358997
    RELAQ042063, ENSP000003842734I2D: score=2 STRING: ENSP00000384273
    NFKB1P198383I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007249I-kappaB kinase/NF-kappaB signaling ISS--

    Find genes that share ontologies with IRAK1BP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRAK1BP1 (IKBP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IRAK1BP1 gene: 
    NM_001010844.3  

    Unigene Cluster for IRAK1BP1:

    Interleukin-1 receptor-associated kinase 1 binding protein 1
    Hs.656212  [show with all ESTs]
    Unigene Representative Sequence: AK096861
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369940(uc003pim.3 uc010kbg.1 uc003pin.2) ENST00000606868
    ENST00000607739 ENST00000606929
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRAK1BP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IRAK1BP1:
    hsa-miR-3163 hsa-miR-548c-3p hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidIRAK1BP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IRAK1BP1
    Predesigned siRNA for gene silencing in human, mouse, rat IRAK1BP1
    Clone
    Products:
         
    OriGene clones in human, mouse for IRAK1BP1 (see all 7)
    OriGene ORF clones in mouse, rat for IRAK1BP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRAK1BP1 (NM_001010844)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK1BP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1BP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IRAK1BP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRAK1BP1
      QuantiTect SYBR Green Assays in human, mouse, rat IRAK1BP1
      QuantiFast Probe-based Assays in human, mouse, rat IRAK1BP1

    Additional mRNA sequence: 

    AK096861.1 AK098678.1 AK309003.1 BC112253.1 BC112255.1 

    11 DOTS entries:

    DT.97811400  DT.103522  DT.99927665  DT.95322922  DT.95227509  DT.95348514  DT.121387442  DT.100675523 
    DT.75177627  DT.95170404  DT.97858748 

    Selected AceView cDNA sequences (see all 61):

    AA679673 AI379905 AK098678 BF513853 AW450696 AI761886 BM830836 AL521825 
    AA480250 BQ435042 BX103697 BM127007 AI917638 BX387112 H81463 BE501177 
    C20908 BX403291 BM808178 AA405600 CK818774 CB321683 AI498886 AI478629 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1BP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                          -                             -     -         
    SP2:                    -     -                                             
    SP3:                    -     -           -     -     -                     
    SP4:                    -                                                   
    SP5:                                                                        


    ECgene alternative splicing isoforms for IRAK1BP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IRAK1BP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCCACAT
    IRAK1BP1 Expression
    About this image


    IRAK1BP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    IRAK1BP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRAK1BP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656212
        Custom PCR Arrays for IRAK1BP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IRAK1BP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRAK1BP1
    QuantiTect SYBR Green Assays in human, mouse, rat IRAK1BP1
    QuantiFast Probe-based Assays in human, mouse, rat IRAK1BP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1BP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IRAK1BP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irak1bp11 , 5 interleukin-1 receptor-associated kinase 1 binding more1, 5 83.91(n)1
    82.63(a)1
      9 (45.16 cM)5
    650991  NM_022986.41  NP_075362.31 
     828298065 
    chicken
    (Gallus gallus)
    Aves IRAK1BP11 interleukin-1 receptor-associated kinase 1 binding more 65.86(n)
    58.23(a)
      421857  NM_001278022.1  NP_001264951.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRAK1BP16
    interleukin-1 receptor-associated kinase 1 binding...
    55(a)
    1 ↔ 1
    1(199770000-199777616)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68932 Xenopus laevis transcribed sequence with weak similarity more 74.71(n)    BX851419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii irak1bp11 interleukin-1 receptor-associated kinase 1 binding more 49.51(n)
    43.1(a)
      553809  NM_001020771.1  NP_001018607.1 


    ENSEMBL Gene Tree for IRAK1BP1 (if available)
    TreeFam Gene Tree for IRAK1BP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IRAK1BP1 (see all 689)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900281211,2
    --79575241(+) GATTAA/GGGCCA 1 -- us2k10--------
    rs109435951,2
    C,F,A,H--79575291(+) TTCTTC/GCAATT 1 -- us2k17Minor allele frequency- G:0.23NS NA WA EA 590
    rs109435961,2
    C,A,H--79575292(+) TCTTCC/TAATTA 1 -- us2k15Minor allele frequency- T:0.36NA WA EA 362
    rs1816654461,2
    --79575538(+) CATGTA/GGTCCC 1 -- us2k10--------
    rs1867902011,2
    C--79575571(+) GAGAAC/TGGCGT 1 -- us2k10--------
    rs1916392431,2
    C--79575600(+) TTGCAA/GTGAGC 1 -- us2k10--------
    rs1839679411,2
    --79575602(+) GCAGTA/GAGCCC 1 -- us2k10--------
    rs356353971,2
    C--79575658(+) AAAAA-/A/AA  
            
    TATAT
    1 -- us2k11NA 2
    rs114440871,2
    C--79575667(+) AAAAA-/TAAATA 1 -- us2k1 tfbs3 trp30--------
    rs77608831,2
    C--79575669(+) AAAAAT/AATATA 1 -- us2k1 tfbs3 trp31Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for IRAK1BP1 (79577189 - 79656157 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IRAK1BP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRAK1BP1
    DNA2.0 Custom Variant and Variant Library Synthesis for IRAK1BP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 615375    OMIM disorders: --


    Find genes that share disorders with IRAK1BP1           About GenesLikeMe


    Export disorders for IRAK1BP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IRAK1BP1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IRAK1BP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. (PubMed id 11096118)1, 2, 3 Vig E....Harrington M.A. (J. Biol. Chem. 2001)
    2. Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. (PubMed id 17079333)1 Luo Y....Harrington M.A. (Am. J. Physiol., Cell Physiol. 2007)
    3. Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. (PubMed id 15485901)1 Kwon H.J....Harrington M.A. (Mol. Cell. Biol. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 134728 HGNC: 17368 AceView: IRAK1BP1 Ensembl:ENSG00000146243 euGenes: HUgn134728
    ECgene: IRAK1BP1 H-InvDB: IRAK1BP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IRAK1BP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IRAK1BP1 gene:
    Search GeneIP for patents involving IRAK1BP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IRAK1BP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IRAK1BP1  
     OriGene MassSpec for IRAK1BP1   OriGene clones in human, mouse for IRAK1BP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for IRAK1BP1   OriGene Purified Protein for IRAK1BP1  
     OriGene ORF clones in mouse, rat for IRAK1BP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IRAK1BP1   OriGene Custom Protein Services for IRAK1BP1  

     
     
     Block miRNA regulation of human, mouse, rat IRAK1BP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IRAK1BP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRAK1BP1 Predesigned siRNA for gene silencing in human, mouse, rat IRAK1BP1
     QuantiFast Probe-based Assays in human, mouse, rat IRAK1BP1 QuantiTect SYBR Green Assays in human, mouse, rat IRAK1BP1
     Custom PCR Arrays for IRAK1BP1 Search Chromatin IP Primers for IRAK1BP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRAK1BP1  GeneGlobe Interaction Network for IRAK1BP1
     Regulatory tfbs in IRAK1BP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IRAK1BP1 GenScript cDNA clones with any tag delivered in your preferred vector for IRAK1BP1
     GenScript Custom Assay Services for IRAK1BP1 GenScript Custom overexpressing Cell Line Services for IRAK1BP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IRAK1BP1 (IKBP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IRAK1BP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IRAK1BP1 antibodies
     IRAK1BP1 proteins
     IRAK1BP1 lysates
     Search for Antibodies for IRAK1BP1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for IRAK1BP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IRAK1BP1
     Antibodies for IRAK1BP1
     ELISAs for IRAK1BP1
     CLIAs for IRAK1BP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for IRAK1BP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1BP1
     SwitchGear 3'UTR luciferase reporter plasmids for IRAK1BP1
     SwitchGear Promoter luciferase reporter plasmids for IRAK1BP1
     Search ThermoFisher Antibodies for IRAK1BP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1BP1
     Browse compounds at ApexBio
     Search Addgene for plasmids for IRAK1BP1
      Search eBioscience for proteins for IRAK1BP1
      Search eBioscience for elisas for IRAK1BP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for IRAK1BP1
     antibodies-online antibodies for IRAK1BP1 (5 products)
     antibodies-online kits for IRAK1BP1 (4 products)
     antibodies-online peptides for IRAK1BP1
     antibodies-online proteins for IRAK1BP1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IRAK1BP1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4