Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IRAK1BP1 Gene

Aliases for IRAK1BP1 Gene

  • Interleukin 1 Receptor Associated Kinase 1 Binding Protein 1 2 3 5
  • IRAK1-Binding Protein 1 3 4
  • Interleukin-1 Receptor-Associated Kinase 1-Binding Protein 1 3
  • ActA Binding Protein 3 3
  • AIP70 3
  • SIMPL 3

External Ids for IRAK1BP1 Gene

Previous GeneCards Identifiers for IRAK1BP1 Gene

  • GC06P079527
  • GC06P079572
  • GC06P079633
  • GC06P076770
  • GC06P079577

Summaries for IRAK1BP1 Gene

GeneCards Summary for IRAK1BP1 Gene

IRAK1BP1 (Interleukin 1 Receptor Associated Kinase 1 Binding Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IRAK1BP1 Gene

  • Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

Additional gene information for IRAK1BP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRAK1BP1 Gene

Genomics for IRAK1BP1 Gene

GeneHancer (GH) Regulatory Elements for IRAK1BP1 Gene

Promoters and enhancers for IRAK1BP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I078866 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 590.7 +0.5 478 2.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF143 IRAK1BP1 PHIP PIR49199
GH06I079075 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 41.8 +210.6 210583 4.9 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 POLR2B PHIP GC06P079077 IRAK1BP1 LCA5 LOC100419073
GH06I078908 Enhancer 0.8 Ensembl ENCODE 52.7 +43.7 43733 3.8 SRF ZNF221 BACH1 FOS ZBTB33 ELF1 MAFK SPI1 EZH2 IRAK1BP1 LCA5 PIR49199 TRF-GAA8-1 GC06M078960
GH06I079419 Enhancer 1.1 Ensembl ENCODE 32.8 +554.1 554140 2.6 INSM2 FEZF1 BATF ZNF2 RFX5 ZNF213 ZNF366 ZSCAN5C SCRT2 ZNF350 ENSG00000231533 LOC100506851 PHIP IRAK1BP1 LCA5 HMGN3 HMGN3-AS1 GC06P079428
GH06I079524 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 +658.3 658280 2.1 FOXA2 ARID4B DMAP1 ZNF48 TCF12 ZNF766 FOS ATF7 ZNF202 MXD4 PHIP IRAK1BP1 LCA5 PIR31629
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IRAK1BP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRAK1BP1 gene promoter:

Genomic Locations for IRAK1BP1 Gene

Genomic Locations for IRAK1BP1 Gene
chr6:78,867,085-78,946,440
(GRCh38/hg38)
Size:
79,356 bases
Orientation:
Plus strand
chr6:79,577,189-79,656,157
(GRCh37/hg19)

Genomic View for IRAK1BP1 Gene

Genes around IRAK1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRAK1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRAK1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRAK1BP1 Gene

Proteins for IRAK1BP1 Gene

  • Protein details for IRAK1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVH5-IKBP1_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase 1-binding protein 1
    Protein Accession:
    Q5VVH5

    Protein attributes for IRAK1BP1 Gene

    Size:
    260 amino acids
    Molecular mass:
    29106 Da
    Quaternary structure:
    • Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1 (By similarity).

neXtProt entry for IRAK1BP1 Gene

Post-translational modifications for IRAK1BP1 Gene

  • Phosphorylation at Ser-56 and/or Ser-62 is required for full activity. Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).

No data available for DME Specific Peptides for IRAK1BP1 Gene

Domains & Families for IRAK1BP1 Gene

Gene Families for IRAK1BP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IRAK1BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IRAK1BP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VVH5

UniProtKB/Swiss-Prot:

IKBP1_HUMAN :
  • The intrinsically disordered region interacts with HSPA1 and HSPA8.
  • Belongs to the IRAK1BP1 family.
Domain:
  • The intrinsically disordered region interacts with HSPA1 and HSPA8.
Family:
  • Belongs to the IRAK1BP1 family.
genes like me logo Genes that share domains with IRAK1BP1: view

Function for IRAK1BP1 Gene

Molecular function for IRAK1BP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity).

Phenotypes From GWAS Catalog for IRAK1BP1 Gene

Gene Ontology (GO) - Molecular Function for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IRAK1BP1: view
genes like me logo Genes that share phenotypes with IRAK1BP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRAK1BP1 Gene

Localization for IRAK1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRAK1BP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRAK1BP1 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IRAK1BP1: view

Pathways & Interactions for IRAK1BP1 Gene

SuperPathways for IRAK1BP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRAK1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling ISS,IEA --
genes like me logo Genes that share ontologies with IRAK1BP1: view

No data available for Pathways by source and SIGNOR curated interactions for IRAK1BP1 Gene

Drugs & Compounds for IRAK1BP1 Gene

No Compound Related Data Available

Transcripts for IRAK1BP1 Gene

Unigene Clusters for IRAK1BP1 Gene

Interleukin-1 receptor-associated kinase 1 binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1BP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for IRAK1BP1 Gene

GeneLoc Exon Structure for
IRAK1BP1
ECgene alternative splicing isoforms for
IRAK1BP1

Expression for IRAK1BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRAK1BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRAK1BP1 Gene:

IRAK1BP1

SOURCE GeneReport for Unigene cluster for IRAK1BP1 Gene:

Hs.656212

Evidence on tissue expression from TISSUES for IRAK1BP1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IRAK1BP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRAK1BP1 Gene

Orthologs for IRAK1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRAK1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRAK1BP1 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia IRAK1BP1 33 34
  • 89.87 (n)
cow
(Bos Taurus)
Mammalia IRAK1BP1 33 34
  • 89.09 (n)
mouse
(Mus musculus)
Mammalia Irak1bp1 33 16 34
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Irak1bp1 33
  • 81.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IRAK1BP1 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRAK1BP1 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRAK1BP1 33 34
  • 65.86 (n)
lizard
(Anolis carolinensis)
Reptilia IRAK1BP1 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irak1bp1 33
  • 68.53 (n)
Str.9202 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6893 33
zebrafish
(Danio rerio)
Actinopterygii irak1bp1 33 34
  • 49.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3890 34
  • 34 (a)
OneToOne
Species where no ortholog for IRAK1BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRAK1BP1 Gene

ENSEMBL:
Gene Tree for IRAK1BP1 (if available)
TreeFam:
Gene Tree for IRAK1BP1 (if available)

Paralogs for IRAK1BP1 Gene

No data available for Paralogs for IRAK1BP1 Gene

Variants for IRAK1BP1 Gene

Sequence variations from dbSNP and Humsavar for IRAK1BP1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs759380520 likely-pathogenic, Syndromic intellectual disability 78,955,243(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000006445 -- 78,892,209(+) A/C/G intron_variant
rs1000025837 -- 78,870,557(+) A/G intron_variant
rs1000044372 -- 78,940,322(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000047406 -- 78,969,755(+) C/G genic_downstream_transcript_variant, intron_variant

Variation tolerance for IRAK1BP1 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRAK1BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRAK1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IRAK1BP1 Gene

Disorders for IRAK1BP1 Gene

Additional Disease Information for IRAK1BP1

No disorders were found for IRAK1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRAK1BP1 Gene

Publications for IRAK1BP1 Gene

  1. SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. (PMID: 11096118) Vig E … Harrington MA (The Journal of biological chemistry 2001) 2 3 4 58
  2. Differential immune mechanism to HIV-1 Tat variants and its regulation by AEA [corrected]. (PMID: 25943894) Krishnan G … Chatterjee N (Scientific reports 2015) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. (PMID: 24165912) He J … Gu D (Circulation. Cardiovascular genetics 2013) 3 58
  5. Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription. (PMID: 17079333) Luo Y … Harrington MA (American journal of physiology. Cell physiology 2007) 3 58

Products for IRAK1BP1 Gene

Sources for IRAK1BP1 Gene

Content
Loading form....