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IRAK1 Gene

protein-coding   GIFtS: 70
GCID: GC0XM153277

Interleukin-1 Receptor-Associated Kinase 1

  See IRAK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin-1 Receptor-Associated Kinase 11 2     pelle2
IRAK2 3     Pelle Homolog2
IRAK-12 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 61121   Entrez Gene: 36542   Ensembl: ENSG000001842167   OMIM: 3002835   UniProtKB: P516173   

Export aliases for IRAK1 gene to outside databases

Previous GC identifers: GC0XM147413 GC0XM149730 GC0XM150861 GC0XM151743 GC0XM152796 GC0XM152929 GC0XM141927


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRAK1 Gene:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases
that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially
responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRAK1 Gene:
IRAK1 (interleukin-1 receptor-associated kinase 1) is a protein-coding gene. Diseases associated with IRAK1 include pediatric systemic lupus erythematosus, and systemic lupus erythematosus. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is IRAK4.

UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
Function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against
foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by
MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1
phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin
ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then,
the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the
IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA
and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP
to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7
(IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type
I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and
phosphorylates STAT3

Gene Wiki entry for IRAK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRAK1 gene promoter:
         Elk-1   c-Rel   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRAK1 promoter sequence
   Search Chromatin IP Primers for IRAK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRAK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

IRAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153277:  view genomic region     (about GC identifiers)

Start:
153,275,951 bp from pter      End:
153,285,431 bp from pter
Size:
9,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617 (See protein sequence)
Recommended Name: Interleukin-1 receptor-associated kinase 1  
Size: 712 amino acids; 76537 Da
Cofactor: Magnesium
Subunit: Homodimer (By similarity). Interacts with TOLLIP; this interaction occurs in the cytosol prior to
receptor activation. Interacts with IL1RL1. Forms a complex with TRAF6, PELI1, IRAK4 and MYD88. Interaction with
MYD88 recruits IRAK1 to the stimulated receptor complex. The TRAF6-PELI1-IRAK1-IRAK4-MYD88 complex recruits
MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents complex
formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression.
Interacts with IRAK1BP1 (By similarity). Interacts (when polyubiquitinated) with IKBKG/NEMO. Interacts with
RSAD2/viperin (By similarity)
Secondary accessions: D3DWW3 D3DWW4 Q7Z5V4 Q96C06 Q96RL2
Alternative splicing: 4 isoforms:  P51617-1   P51617-2   P51617-3   P51617-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IRAK1: NX_P51617

Explore proteomics data for IRAK1 at MOPED

Post-translational modifications: 

  • Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting
    in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387
    phosphorylation in the activation loop is required to achieve full enzymatic activity1
  • Polyubiquitinated after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with
    polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also
    sumoylated; leading to nuclear translocation1
  • Ubiquitination2 at Lys342, Lys355, Lys397
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for IRAK1 (P51617)
     GEPAAPG  LGDFGLA 


    See IRAK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020413.1  NP_001020414.1  NP_001560.2  

    ENSEMBL proteins: 
     ENSP00000358997   ENSP00000358991   ENSP00000399974   ENSP00000411809   ENSP00000358990  
     ENSP00000410953   ENSP00000406249   ENSP00000377291   ENSP00000392662   ENSP00000403730  
     ENSP00000377287  
    Reactome Protein details: P51617

    IRAK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IRAK1 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Custom Protein Services for IRAK1
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    Novus Biologicals IRAK1 Proteins
    Novus Biologicals IRAK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRAK1

     
    Search eBioscience for Proteins for IRAK1 

     
    antibodies-online proteins for IRAK1 (6 products) 

     
    antibodies-online peptides for IRAK1

    IRAK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRAK1
    R&D Systems Antibodies for IRAK1
    Cell Signaling Technology (CST) Antibodies for IRAK1 
    OriGene Antibodies for IRAK1
    OriGene Custom Antibody Services for IRAK1
    Novus Biologicals IRAK1 Antibodies
    Search for Antibodies for IRAK1 at Abcam
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    ThermoFisher Antibody for IRAK1
    antibodies-online antibodies for IRAK1 (240 products) 

    IRAK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRAK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRAK1
    Cloud-Clone Corp. CLIAs for IRAK1
    Search eBioscience for ELISAs for IRAK1 
    antibodies-online kits for IRAK1 (22 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: interleukin-1 receptor-associated kinase 1
    Interleukin-1 receptor-associated kinase (IRAK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P51617

    ProtoNet protein and cluster: P51617

    UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
    Domain: The ProST region is composed of many proline and serine residues (more than 20 of each) and some
    threonines. This region is the site of IRAK-1 hyperphosphorylation
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with IRAK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRAK1_HUMAN, P51617
    Function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against
    foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by
    MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1
    phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin
    ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then,
    the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the
    IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA
    and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP
    to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7
    (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type
    I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and
    phosphorylates STAT3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for IRAK1:
    interleukin-1 receptor-associated kinase,100kDa,Drosophila Pelle homolog,forming a complex with IL1R1 after
    induction by IL1 through its association with IL1RAP and subsequently interacting with TRAF6 required for IL-1
    mediated NFKB activation,see symbols

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS--
    GO:0004674protein serine/threonine kinase activity NAS11397809
    GO:0004704NF-kappaB-inducing kinase activity TAS8599092
    GO:0004713protein tyrosine kinase activity ----
    GO:0004842ubiquitin-protein ligase activity TAS--
         
    Find genes that share ontologies with IRAK1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for IRAK1:
     Decreased nuclei size in G2M  Decreased substrate adherent c  Decreased telomerase activity  Increased colony dispersion (i 
     Increased mitotic index  Increased viability with TRAIL 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Irak1):
     cardiovascular system  cellular  hematopoietic system  immune system  mortality/aging 
     muscle  normal 

    Find genes that share phenotypes with IRAK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IRAK1: Irak1tm1Jth Irak1tm1Wpfl

       genOway: Develop your customized and physiologically relevant rodent model for IRAK1

    miRNA
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    miRTarBase miRNAs that target IRAK1:
    hsa-mir-215-5p (MIRT024479), hsa-mir-132-3p (MIRT045847), hsa-mir-192-5p (MIRT026216), hsa-mir-423-3p (MIRT042485), hsa-mir-146b-5p (MIRT005395), hsa-mir-330-5p (MIRT038255), hsa-mir-193b-3p (MIRT041223), hsa-mir-222-3p (MIRT046662), hsa-mir-1226-3p (MIRT036505), hsa-mir-92a-3p (MIRT049357), hsa-mir-744-5p (MIRT037612), hsa-mir-146a-5p (MIRT000712), hsa-mir-17-5p (MIRT051021), hsa-mir-93-3p (MIRT038891), hsa-mir-328-3p (MIRT043810)

    Block miRNA regulation of human, mouse, rat IRAK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRAK1 (see all 12):
    hsa-miR-142-3p hsa-miR-3164 hsa-miR-146a hsa-miR-134 hsa-miR-4253 hsa-miR-661 hsa-miR-617 hsa-miR-3118
    SwitchGear 3'UTR luciferase reporter plasmidIRAK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRAK1
    Predesigned siRNA for gene silencing in human, mouse, rat IRAK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRAK1

    Clone
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    OriGene ORF clones in mouse, rat for IRAK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IRAK1 (NM_001025242)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1
    Addgene plasmids for IRAK1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRAK1_HUMAN, P51617: Cytoplasm. Nucleus. Lipid droplet (By similarity). Note=Translocates to the nucleus when
    sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    endosome4
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005811lipid particle ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with IRAK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRAK1 About   (see all 35)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    IL-1 Family Signaling Pathways0.44
    Immune response IL 1 signaling pathway0.42
    2Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL-1 Signaling Pathway0.00
    IL1-mediated signaling events0.45
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    4Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL 1 beta dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    5Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32


    Find genes that share SuperPaths with IRAK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IRAK1
        IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IRAK1 (see all 13)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway

    1 Cell Signaling Technology (CST) Pathway for IRAK1
        NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for IRAK1 (see all 11)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response IL-12-induced IFN-gamma production
    Immune response TLR signaling pathways
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for IRAK1 (see all 7)
        EBV LMP1 signaling
    Apoptosis Modulation and Signaling
    IL-1 Signaling Pathway
    Toll-like receptor signaling pathway
    IL1-mediated signaling events

    Selected Reactome Pathways for IRAK1 (see all 14)
        p75NTR recruits signalling complexes
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    IRAK1 recruits IKK complex
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    Selected Kegg Pathways  (Kegg details for IRAK1) (see all 11):
        NF-kappa B signaling pathway
    Apoptosis
    Toll-like receptor signaling pathway
    Neurotrophin signaling pathway
    Pertussis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRAK1 (see all 9): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRAK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRAK1 (P516171, 2, 3 ENSP000003589974) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K31, 2, 3EBI-358664,EBI-359276 MINT-50484 I2D: score=10 
    IRAK2O431872, 3, ENSP000002564584MINT-50487 I2D: score=5 STRING: ENSP00000256458
    IRF7Q929851, 3, ENSP000003294114EBI-358664,EBI-968267 I2D: score=4 STRING: ENSP00000329411
    PELI3Q8N2H92, 3, ENSP000003225324MINT-2845059 I2D: score=4 STRING: ENSP00000322532
    TAB1Q157502, 3, ENSP000002161604MINT-49176 I2D: score=2 STRING: ENSP00000216160
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0001959regulation of cytokine-mediated signaling pathway IMP10383454
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS10383454
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with IRAK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRAK1

    3 HMDB Compounds for IRAK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for IRAK1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 79.6 9 11518704 (4), 11259596 (2), 12242293 (2)
    tab-1 65.1 4 11518704 (2), 11745395 (1), 12242293 (1)
    lipoteichoic acid 56.1 6 12691617 (3), 18722665 (1), 15057745 (1)
    threonine 43.1 10 8846922 (1), 10609879 (1), 7527496 (1), 18073537 (1) (see all 9)
    endotoxin 40.3 4 10811644 (1), 15275867 (1), 12032143 (1)
    flagellin 35.5 2 15632166 (1)
    serine 32 15 8846922 (1), 10609879 (1), 7527496 (1), 12856330 (1) (see all 11)
    phenylarsine oxide 30.9 2 12751790 (1)
    peptidoglycan 28.9 7 11254583 (3), 14660668 (2), 17182109 (1)
    diamide 25.9 1 12751790 (1)



    Find genes that share compounds with IRAK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRAK1 gene (3 alternative transcripts): 
    NM_001025242.1  NM_001025243.1  NM_001569.3  

    Unigene Cluster for IRAK1:

    Interleukin-1 receptor-associated kinase 1
    Hs.522819  [show with all ESTs]
    Unigene Representative Sequence: L76191
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369980(uc004fjr.1 uc004fjs.1 uc004fjt.1) ENST00000369974
    ENST00000444230 ENST00000477274 ENST00000455690 ENST00000369973 ENST00000444254
    ENST00000437278 ENST00000393687 ENST00000429936(uc004fju.2) ENST00000443220
    ENST00000467236 ENST00000463031 ENST00000393682
    miRNA
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    hsa-miR-142-3p hsa-miR-3164 hsa-miR-146a hsa-miR-134 hsa-miR-4253 hsa-miR-661 hsa-miR-617 hsa-miR-3118
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IRAK1
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    OriGene ORF clones in mouse, rat for IRAK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IRAK1 (NM_001025242)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1
    Addgene plasmids for IRAK1 
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      QuantiTect SYBR Green Assays in human, mouse, rat IRAK1
      QuantiFast Probe-based Assays in human, mouse, rat IRAK1

    Additional mRNA sequence: 

    AF346607.1 BC014963.1 BC054000.1 DQ054788.1 L76191.1 

    Selected DOTS entries (see all 32):

    DT.453019  DT.92458493  DT.100039195  DT.97776626  DT.100807259  DT.100807257  DT.101984900  DT.95289692 
    DT.97776603  DT.95289607  DT.100807255  DT.100060997  DT.100807256  DT.100807262  DT.121293863  DT.121294261 
    DT.100807261  DT.102830352  DT.121293684  DT.95289625  DT.99950780  DT.100807263  DT.95289577  DT.100765449 

    Selected AceView cDNA sequences (see all 629):

    AI625106 BE794074 BM853377 AA970401 BU527196 AW189060 CA428380 CA422983 
    AW673153 BQ642339 BF969766 BQ422338 AI609170 BQ000477 BQ438898 BG230599 
    AA693385 BM551933 BU538068 BM479461 BQ225395 BU857000 BX424462 BG480351 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c
    SP1:                    -                                                                                                                                 
    SP2:                    -                                                                                         -                                       
    SP3:                    -                                                                                   -                                             
    SP4:                                                                                            -     -                                                   
    SP5:                                                              -     -                                                                                 


    ECgene alternative splicing isoforms for IRAK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IRAK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCGTGAA
    IRAK1 Expression
    About this image


    IRAK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Mature Ganglion Cells Ganglion Cell Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    IRAK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRAK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522819

    UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
    Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1
    being more strongly expressed than isoform 2

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRAK1 (see all 9): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Antibacterial Response in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IRAK1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irak11 , 5 interleukin-1 receptor-associated kinase 11, 5 82.04(n)1
    81.38(a)1
      X (37.61 cM)5
    161791  NM_001177975.11  NP_001171446.11 
     740139145 
    lizard
    (Anolis carolinensis)
    Reptilia IRAK16
    interleukin-1 receptor-associated kinase 1
    47(a)
    1 ↔ 1
    2(88411488-88457459)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.155512 Xenopus laevis transcribed sequence with weak similarity more 71.36(n)    BJ071855.1 
    zebrafish
    (Danio rerio)
    Actinopterygii irak11 interleukin-1 receptor-associated kinase 1 51.27(n)
    46.18(a)
      569226  XM_005166703.1  XP_005166760.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pll3 antifungal humoral response (sensu
    Invertebrata) more
    34(a)   3 97E11   --
    worm
    (Caenorhabditis elegans)
    Secernentea pik-13   -- 40(a)   IV(13416966-13421694)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G327101 AT4G32710 48.47(n)
    42.51(a)
      3770575  NM_119424.4  NP_567903.3 


    ENSEMBL Gene Tree for IRAK1 (if available)
    TreeFam Gene Tree for IRAK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRAK1 gene
    IRAK42  IRAK22  IRAK32  

    Find genes that share paralogs with IRAK1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IRAK1
    PGOHUM00000235550


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IRAK1 (see all 253)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0405754
    A breast pleomorphic lobular carcinoma sample4--see VAR_0405752 Q H mis40--------
    VAR_0405804
    A lung adenocarcinoma sample4--see VAR_0405802 S G mis40--------
    VAR_0405744
    A glioblastoma multiforme sample4--see VAR_0405742 V M mis40--------
    rs1901628671,2
    --153143616(+) TGCCCA/GGGCTG 3 -- ds5001 int10--------
    rs1817839691,2
    --153143765(+) ACGGGA/GTTTCG 3 -- ds5001 int10--------
    rs1499718791,2
    C--153143914(+) AAAATA/CAAAGA 3 -- ds5001 int10--------
    rs30278981,2
    C,F,A,H--153144032(+) GAACCA/CTGAAG 3 -- ds5001 int128--NA EU EA NS CSA 2866
    rs1865352281,2
    --153144138(+) CTGGAC/TGTCAC 3 -- ut310--------
    rs1909423651,2
    --153144370(+) TCTCAC/GTGTCT 3 -- ut310--------
    rs30278991,2
    C,F,H--153144499(+) TGTGGC/TGCCCA 3 -- ut31 ese313Minor allele frequency- T:0.02NS EA NA EU WA 618

    HapMap Linkage Disequilibrium report for IRAK1 (153275951 - 153285431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IRAK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    nsv469867CNV Complex16826518

    Human Gene Mutation Database (HGMD): IRAK1
    Locus Specific Mutation Databases (LSDB): IRAK1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRAK1
    DNA2.0 Custom Variant and Variant Library Synthesis for IRAK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300283    OMIM disorders: --

    2 diseases for IRAK1:    
    About MalaCards
    pediatric systemic lupus erythematosus    systemic lupus erythematosus


    Find genes that share disorders with IRAK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IRAK1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 54.1 25 12566447 (2), 9261174 (2), 18759964 (2), 17599092 (1) (see all 18)
    inflammation 41.7 5 16751410 (1), 17382928 (1), 18854126 (1), 20053980 (1)
    bacterial infections 36.3 2 15670593 (1), 17997719 (1)
    tumors 32.8 31 20028769 (3), 12566447 (2), 9261174 (2), 18759964 (2) (see all 20)
    atherosclerosis 2.04 7 15465816 (2), 17382928 (2), 16169330 (1)
    asthma 0 2 19968634 (1)
    sepsis 0 5 16528020 (4)
    shock 0 1 16528020 (1)
    renal disease 0 1 19329491 (1)
    primary tumor 0 1 11165677 (1)

    Genetic Association Database (GAD): IRAK1
    Human Genome Epidemiology (HuGE) Navigator: IRAK1 (28 documents)

    Export disorders for IRAK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for IRAK1 gene, integrated from 10 sources (see all 388):
    (articles sorted by number of sources associating them with IRAK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IRAK: a kinase associated with the interleukin-1 receptor. (PubMed id 8599092)1, 2, 3, 9 Cao Z.... Gao X. (Science 1996)
    2. Sequential autophosphorylation steps in the interleukin-1 receptor- associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. (PubMed id 14625308)1, 2, 9 Kollewe C.... Martin M.U. (J. Biol. Chem. 2004)
    3. IRAK1 serves as a novel regulator essential for lipopolysaccharide- induced interleukin-10 gene expression. (PubMed id 15465816)1, 2, 9 Huang Y.... Li L. (J. Biol. Chem. 2004)
    4. Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. (PubMed id 14684752)1, 2, 9 Mamidipudi V.... Wooten M.W. (J. Biol. Chem. 2004)
    5. Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. (PubMed id 16690127)1, 2, 9 Su J.... Li L. (Mol. Immunol. 2007)
    6. Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. (PubMed id 16528020)1, 4, 9 Arcaroli J....Abraham E. (Am. J. Respir. Crit. Care Med. 2006)
    7. IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase. (PubMed id 11960013)1, 2, 9 Li S.... Wesche H. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. (PubMed id 19329491)1, 4, 9 Jacob C.O....Mohan C. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    9. IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor- associated kinase phosphorylation and IL-1 responsiveness. (PubMed id 15084582)1, 2, 9 Qin J.... Li X. (J. Biol. Chem. 2004)
    10. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). (PubMed id 20400509)1, 2, 9 Dunne A.... O'Neill L.A. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3654 HGNC: 6112 AceView: IRAK1 Ensembl:ENSG00000184216 euGenes: HUgn3654
    ECgene: IRAK1 Kegg: 3654 H-InvDB: IRAK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IRAK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IRAK1 gene:
    Search GeneIP for patents involving IRAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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