Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRAK1 Gene

protein-coding   GIFtS: 70
GCID: GC0XM153277

interleukin-1 receptor-associated kinase 1
 Explore 45 diseases affiliated with
IRAK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRAK1    

Aliases
for IRAK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin-1 Receptor-Associated Kinase 11 2     EC 2.7.11.13 8
IRAK1 2 3     Pelle Homolog2
Pelle1     EC 2.7.118
IRAK-12 3     

External Ids:    HGNC: 61121   Entrez Gene: 36542   Ensembl: ENSG000001842167   OMIM: 3002835   UniProtKB: P516173   

Export aliases for IRAK1 gene to outside databases

Previous GC identifers: GC0XM147413 GC0XM149730 GC0XM150861 GC0XM151743 GC0XM152796 GC0XM152929 GC0XM141927


Summaries
for IRAK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRAK1:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that
become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for
IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
Function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against
foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to
the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and
subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1,
PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of
IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the
NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear
translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent
degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to
the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state.
When sumoylated, translocates to the nucleus and phosphorylates STAT3

Gene Wiki entry for IRAK1


Genomic Views
for IRAK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRAK1 gene promoter:
         Elk-1   c-Rel   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRAK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRAK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

IRAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRAK1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153277:  view genomic region     (about GC identifiers)

Start:
 153,275,951 bp from pter      End:
 153,285,431 bp from pter
Size:
 9,481 bases      Orientation:
 minus strand

Proteins
for IRAK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617 (See protein sequence)
Recommended Name: Interleukin-1 receptor-associated kinase 1  
Size: 712 amino acids; 76537 Da
Cofactor: Magnesium
Subunit: Homodimer (By similarity). Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor
activation. Interacts with IL1RL1. Forms a complex with TRAF6, PELI1, IRAK4 and MYD88. Interaction with MYD88 recruits
IRAK1 to the stimulated receptor complex. The TRAF6-PELI1-IRAK1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and
TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents complex formation and hence
negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Interacts with IRAK1BP1
(By similarity). Interacts (when polyubiquitinated) with IKBKG/NEMO. Interacts with RSAD2/viperin (By similarity)
Subcellular location: Cytoplasm. Nucleus. Lipid droplet (By similarity). Note=Translocates to the nucleus when
sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity)
Secondary accessions: D3DWW3 D3DWW4 Q7Z5V4 Q96C06 Q96RL2
Alternative splicing: 4 isoforms:  P51617-1   P51617-2   P51617-3   P51617-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IRAK1: NX_P51617

Post-translational modifications:

  • Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a
    • conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation
    in the activation loop is required to achieve full enzymatic activity1
  • Polyubiquitinated after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with
    • polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated;
    leading to nuclear translocation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51617

    • 2 DME Specific Peptides for IRAK1 (P51617)
     GEPAAPG  LGDFGLA 

    IRAK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020413.1  NP_001020414.1  NP_001560.2  

    ENSEMBL proteins: 
     ENSP00000358997   ENSP00000358991   ENSP00000399974   ENSP00000411809   ENSP00000358990  
     ENSP00000410953   ENSP00000406249   ENSP00000377291   ENSP00000392662   ENSP00000403730  
     ENSP00000377287  
    Reactome Protein details: P51617
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IRAK1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IRAK1
    OriGene Protein Over-expression Lysate (see all 4): IRAK1
    OriGene Custom Protein Services for IRAK1 
    GenScript Custom Purified and Recombinant Proteins Services for IRAK1
    Novus Biologicals IRAK1 Proteins
    Novus Biologicals IRAK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRAK1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus IEA--
    GO:0005811lipid particle ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    IRAK1 for ontologies           About GeneDecksing



    IRAK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRAK1
    R&D Systems Antibodies for IRAK1
    Cell Signaling Technology (CST) Antibodies for IRAK1 
    OriGene Antibodies: IRAK1
    OriGene Custom Antibody Services for IRAK1 
    GenScript Custom Superior Antibodies Services for IRAK1
    Novus Biologicals IRAK1 Antibodies
    Abcam antibodies for IRAK1 
    Uscn Antibodies for IRAK1
    ThermoFisher Antibody for IRAK1

    Assay Products for IRAK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRAK1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IRAK1

    Protein Domains /
    Families
    for IRAK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRAK1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry P51617

    ProtoNet protein and cluster: P51617

    UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
    Domain: The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines.
    This region is the site of IRAK-1 hyperphosphorylation
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    Function
    for IRAK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
    Function: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against
    foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to
    the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and
    subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1,
    PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of
    IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the
    NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear
    translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent
    degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to
    the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state.
    When sumoylated, translocates to the nucleus and phosphorylates STAT3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for IRAK1:
    interleukin-1 receptor-associated kinase,100kDa,Drosophila Pelle homolog,forming a complex with IL1R1 after induction
    by IL1 through its association with IL1RAP and subsequently interacting with TRAF6 required for IL-1 mediated NFKB
    activation,see symbols

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target IRAK1:
    hsa-mir-146b-5p (MIRT005395), hsa-mir-146a (MIRT000712)

    OriGene 3'-UTR Clone (see all 3): IRAK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK1 (see all 12):
    hsa-miR-142-3p hsa-miR-3164 hsa-miR-146a hsa-miR-134 hsa-miR-4253 hsa-miR-661 hsa-miR-617 hsa-miR-3118
    SwitchGear 3'UTR luciferase reporter plasmid: IRAK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK1 (see all 7)
    OriGene shRNA RFP: IRAK1
    OriGene siRNA: IRAK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRAK1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1 (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IRAK1 (NM_001025242)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IRAK1
    Search LifeMap BioReagents cell lines for IRAK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS--
    GO:0004674protein serine/threonine kinase activity NAS11397809
    GO:0004704NF-kappaB-inducing kinase activity TAS8599092
    GO:0004842ubiquitin-protein ligase activity TAS--
    GO:0005149interleukin-1 receptor binding IEA--


    IRAK1 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for IRAK1:
     Decreased nuclei size in G2M  Decreased substrate adherent c  Decreased telomerase activity  Increased colony dispersion (i 
     Increased mitotic index  Increased viability with TRAIL 

    Animal Models:
         Mouse knock-outs for IRAK1: Irak1tm1Jth Irak1tm1Wpfl
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Irak1):
     cardiovascular system  cellular  immune system  mortality/aging  muscle 
     normal 

    IRAK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRAK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2Toll Comparative Pathway
    		Toll Comparative Pathway1.00
    		Immune response MIF in innate immunity response0.46
    		TLR-TRIF Pathway0.61
    		IL-1 Pathway0.39
    		Immune response_MIF in innate immunity response0.46
    		iNOS Signaling0.34
    3p75NTR signals via NF-kB
    		p75NTR signals via NF-kB1.00
    		p75NTR recruits signalling complexes0.81
    		NF-kB is activated and signals survival0.81
    		TRAF6 is auto-ubiquitinated0.56
    4Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Chagas disease (American trypanosomiasis)0.31
    5Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		IL-1 beta-dependent CFTR expression0.43
    		Bacterial infections in CF airways0.78

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for IRAK1 (see all 7)
        Transcription NF-kB signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response IL-12-induced IFN-gamma production
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    1 R&D Systems Pathway for IRAK1
        Toll-Like receptor Signaling Pathways

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRAK1 (see all 13)
        MAPK Signaling
    14-3-3 Induced Apoptosis
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway

    1 Cell Signaling Technology (CST) Pathway for IRAK1
        NF-kappaB Signaling

    5/11 GeneGo (Thomson Reuters) Pathways for IRAK1 (see all 11)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Immune response IL-12-induced IFN-gamma production
    Immune response TLR signaling pathways
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    5/6 BioSystems Pathways for IRAK1 (see all 6) 
        EBV LMP1 signaling
    Apoptosis Modulation and Signaling
    IL-1 Signaling Pathway
    Toll-like receptor signaling pathway
    IL1-mediated signaling events

    5/40        Reactome Pathways for IRAK1 (see all 40)
        TAK1 is activated within the TAK1 complex
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    Toll Like Receptor 3 (TLR3) Cascade


    5/9         Kegg Pathways  (Kegg details for IRAK1) (see all 9):
        Apoptosis
    Toll-like receptor signaling pathway
    Neurotrophin signaling pathway
    Pertussis
    Leishmaniasis


    IRAK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRAK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/152 Interacting proteins for IRAK1 (P516171, 2, 3 ENSP000003589974) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK2O431871, 2, 3, ENSP000002564584EBI-358664,EBI-447733 MINT-50487 I2D: score=5 STRING: ENSP00000256458
    TRAF6Q9Y4K31, 2, 3EBI-358664,EBI-359276 MINT-50484 I2D: score=10 
    IRF7Q929851, 3, ENSP000003294114EBI-358664,EBI-2339383 I2D: score=4 STRING: ENSP00000329411
    PELI3Q8N2H92, 3, ENSP000003225324MINT-2845059 I2D: score=4 STRING: ENSP00000322532
    TAB1Q157502, 3, ENSP000002161604MINT-49176 I2D: score=2 STRING: ENSP00000216160
    About this table

    Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0001959regulation of cytokine-mediated signaling pathway IMP10383454
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS10383454
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--


    IRAK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRAK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRAK1 for compounds           About GeneDecksing

    EMD Millipore small molecules for IRAK1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRAK1

    3 HMDB Compounds for IRAK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    10/25 Novoseek chemical compound relationships for IRAK1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 79.6 9 11518704 (4), 11259596 (2), 12242293 (2)
    tab-1 65.1 4 11518704 (2), 11745395 (1), 12242293 (1)
    lipoteichoic acid 56.1 6 12691617 (3), 18722665 (1), 15057745 (1)
    threonine 43.1 10 8846922 (1), 10609879 (1), 7527496 (1), 18073537 (1) (see all 9)
    endotoxin 40.3 4 10811644 (1), 15275867 (1), 12032143 (1)
    flagellin 35.5 2 15632166 (1)
    serine 32 15 8846922 (1), 10609879 (1), 7527496 (1), 12856330 (1) (see all 11)
    phenylarsine oxide 30.9 2 12751790 (1)
    peptidoglycan 28.9 7 11254583 (3), 14660668 (2), 17182109 (1)
    diamide 25.9 1 12751790 (1)

    Search CenterWatch for drugs/clinical trials and news about IRAK1 

    Transcripts
    for IRAK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRAK1 gene (3 alternative transcripts): 
    NM_001025242.1  NM_001025243.1  NM_001569.3  

    Unigene Cluster for IRAK1:

    Interleukin-1 receptor-associated kinase 1
    Hs.522819  [show with all ESTs]
    Unigene Representative Sequence: L76191
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369980(uc004fjr.1 uc004fjs.1 uc004fjt.1) ENST00000369974
    ENST00000444230 ENST00000477274 ENST00000455690 ENST00000369973 ENST00000444254
    ENST00000437278 ENST00000393687 ENST00000429936(uc004fju.2) ENST00000443220
    ENST00000467236 ENST00000463031 ENST00000393682

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): IRAK1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRAK1
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate IRAK1 (see all 12):
    hsa-miR-142-3p hsa-miR-3164 hsa-miR-146a hsa-miR-134 hsa-miR-4253 hsa-miR-661 hsa-miR-617 hsa-miR-3118
    SwitchGear 3'UTR luciferase reporter plasmid: IRAK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK1 (see all 7)
    OriGene shRNA RFP: IRAK1
    OriGene siRNA: IRAK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1 (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IRAK1 (NM_001025242)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRAK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRAK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK1

    Additional cDNA sequence: 

    AF346607.1 BC014963.1 BC054000.1 DQ054788.1 L76191.1 

    24/32 DOTS entries (see all 32):

    DT.453019  DT.92458493  DT.97776626  DT.100039195  DT.100807259  DT.100807257  DT.101984900  DT.95289692 
    DT.97776603  DT.95289607  DT.100807255  DT.100060997  DT.100807256  DT.100807262  DT.121293863  DT.121294261 
    DT.100807261  DT.102830352  DT.121293684  DT.95289625  DT.99950780  DT.100807263  DT.95289577  DT.100765449 

    24/629 AceView cDNA sequences (see all 629):

    CN484507 AI479997 AA862448 AI810785 BM703985 BG386801 AA865164 CR604638 
    BQ941194 AI079738 AW054878 CR611861 BU154977 BE795196 AA547995 BE274458 
    BM479461 AA479041 AW965100 AA099377 AA477523 BU944071 AI625106 BM847434 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IRAK1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c
    SP1:                    -                                                                                                                                 
    SP2:                    -                                                                                         -                                       
    SP3:                    -                                                                                   -                                             
    SP4:                                                                                            -     -                                                   
    SP5:                                                              -     -                                                                                 


    ECgene alternative splicing isoforms for IRAK1

    Expression
    for IRAK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRAK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCCCGTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRAK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IRAK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRAK1

    SOURCE GeneReport for Unigene cluster: Hs.522819

    UniProtKB/Swiss-Prot: IRAK1_HUMAN, P51617
    Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being
    more strongly expressed than isoform 2

        SABiosciences Expression via Pathway-Focused PCR Arrays including IRAK1 (see all 9): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRAK1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1

    Orthologs
    for IRAK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IRAK1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia IRAK16
    		 --
    		 46(a)
    		 1 ↔ 1
    		 2(88411488-88457459)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.155512 Xenopus laevis transcribed sequence with weak similarity more 71.36(n)    BJ071855.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii irak16
    		 interleukin-1 receptor-associated kinase 1
    		 37(a)
    		 1 ↔ 1
    		 8(8107727-8140332)
    fruit fly
    (Drosophila melanogaster)    		 Insecta pll3 antifungal humoral response (sensu
    Invertebrata) more    		 34(a)   3 97E11   --
    worm
    (Caenorhabditis elegans)    		 Secernentea pik-13   -- 40(a)   IV(13416966-13421694)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G247906
    AT5G028006
    (see all 38)    		 protein kinase family protein
    (see all 38)    		 31(a)
    29(a)
    (see all 38)    		 many ↔ many
    many ↔ many
    (see all 38)    		 3(9052982-9054531)
    5(635228-637503)
    rice
    (Oryza sativa)    		 Liliopsida Os01g01952001 hypothetical protein 46.42(n)
    40.59(a)    		   4327321  NM_001048824.1  NP_001042289.1 


    ENSEMBL Gene Tree for IRAK1 (if available)
    TreeFam Gene Tree for IRAK1 (if available) 

    Paralogs
    for IRAK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRAK1 gene
    IRAK42  IRAK22  IRAK32  

    IRAK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IRAK1
    PGOHUM00000235550


    Genomic Variants
    for IRAK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in IRAK1 are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1901628671,2
    		--153275474(+) TGCCCA/GGGCTG 3 -- int1 ds50010--------
    rs1817839691,2
    		--153275623(+) ACGGGA/GTTTCG 3 -- ds5001 int10--------
    rs1499718791,2
    		--153275772(+) AAAATA/CAAAGA 3 -- int1 ds50010--------
    rs30278981,2
    		C,F,A,H,--153275890(+) GAACCA/CTGAAG 3 -- ds5001 int128--NA EU EA NS CSA 2866
    rs1865352281,2
    		--153275996(+) CTGGAC/TGTCAC 3 -- ut310--------
    rs1909423651,2
    		--153276228(+) TCTCAC/GTGTCT 3 -- ut310--------
    rs30278991,2
    		C,F,H,--153276357(+) TGTGGC/TGCCCA 3 -- ut31 ese313Minor allele frequency- T:0.02NS EA NA EU WA 618
    rs1448585311,2
    		--153276685(+) CGTGCA/GCTACC 3 -- ut310--------
    rs1823673731,2
    		--153276693(+) ACCACA/GCCAGG 3 -- ut310--------
    rs1851722671,2
    		--153276901(+) GTGCAG/TGGTGG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for IRAK1 (153275951 - 153285431 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for IRAK1
         3 CNVs: 97104 83864 83863
         6 Indels: 83865 97106 83866 97107 97105 83867
    Human Gene Mutation Database (HGMD): IRAK1

    Locus Specific Mutation Databases (LSDB): IRAK1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRAK1
    DNA2.0 Custom Variant and Variant Library Synthesis for IRAK1

    Disorders / Diseases
    for IRAK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRAK1 for disorders           About GeneDecksing

    OMIM gene information: 300283    OMIM disorders: --

    20/45 diseases for IRAK1 (see all 45):    About MalaCards
    non-small cell lung carcinoma    interleukin receptor    type 2 diabetes mellitus    psoriatic arthritis
    ischemic heart disease    systemic lupus erythematosus    malt lymphoma    lupus erythematosus
    diabetes mellitus    papillary thyroid carcinoma    rheumatoid arthritis    chagas disease
    arthritis    thyroid carcinoma    down syndrome    trypanosomiasis
    lung carcinoma    toxoplasmosis    atopy    leishmaniasis

    10/13 Novoseek disease relationships for IRAK1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 54.1 25 12566447 (2), 9261174 (2), 18759964 (2), 17599092 (1) (see all 18)
    inflammation 41.7 5 16751410 (1), 17382928 (1), 18854126 (1), 20053980 (1)
    bacterial infections 36.3 2 15670593 (1), 17997719 (1)
    tumors 32.8 31 20028769 (3), 12566447 (2), 9261174 (2), 18759964 (2) (see all 20)
    atherosclerosis 2.04 7 15465816 (2), 17382928 (2), 16169330 (1)
    asthma 0 2 19968634 (1)
    sepsis 0 5 16528020 (4)
    shock 0 1 16528020 (1)
    renal disease 0 1 19329491 (1)
    primary tumor 0 1 11165677 (1)

    Genetic Association Database (GAD): IRAK1
    Human Genome Epidemiology (HuGE) Navigator: IRAK1 (28 documents)

    Export disorders for IRAK1 gene to outside databases

    Publications
    for IRAK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRAK1 gene, integrated from 9 sources (see all 369):
    (articles sorted by number of sources associating them with IRAK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. IRAK: a kinase associated with the interleukin-1 receptor. (PubMed id 8599092)1, 2, 3, 9 Cao Z.... Gao X. (1996)
    2. Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. (PubMed id 14625308)1, 2, 9 Kollewe C....Martin M.U. (2004)
    3. IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. (PubMed id 15465816)1, 2, 9 Huang Y....Li L. (2004)
    4. Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C. (PubMed id 14684752)1, 2, 9 Mamidipudi V....Wooten M.W. (2004)
    5. Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. (PubMed id 16690127)1, 2, 9 Su J....Li L. (2007)
    6. IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase. (PubMed id 11960013)1, 2, 9 Li S.... Wesche H. (2002)
    7. IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor- associated kinase phosphorylation and IL-1 responsiveness. (PubMed id 15084582)1, 2, 9 Qin J.... Li X. (2004)
    8. IRAK1 and IRAK4 promote phosphorylation, ubiquitinati on, and degradation of MyD88 adaptor-like (Mal). (PubMed id 20400509)1, 2, 9 Dunne A....O'Neill L.A. (2010)
    9. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. (PubMed id 18347055)1, 2, 9 Conze D.B....Ashwell J.D. (2008)
    10. IRAK1b, a novel alternative splice variant of interleukin-1 receptor- associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. (PubMed id 11397809)1, 2, 9 Jensen L.E. and Whitehead A.S. (2001)

    External Searches for IRAK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IRAK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3654 HGNC: 6112 AceView: IRAK1 Ensembl:ENSG00000184216 euGenes: HUgn3654
    ECgene: IRAK1 Kegg: 3654 H-InvDB: IRAK1

    Other Databases showing IRAK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IRAK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRAK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IRAK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IRAK1 gene:
    Search GeneIP for patents involving IRAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IRAK1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of IRAK1
     EMD Millipore Purified and/or Recombinant IRAK1 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for IRAK1
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for IRAK1 (IRAK1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for IRAK1   OriGene shRNA RFP for IRAK1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRAK1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRAK1  
     OriGene Protein Over-expression Lysate for IRAK1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IRAK1   OriGene 3'-UTR Clone for IRAK1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRAK1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for IRAK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IRAK1   OriGene Custom Protein Services for IRAK1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRAK1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRAK1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRAK1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRAK1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRAK1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRAK1
     GenScript Custom Purified and Recombinant Proteins Services for IRAK1 GenScript cDNA clones with any tag delivered in your preferred vector for IRAK1
     GenScript Custom Assay Services for IRAK1 GenScript Custom Superior Antibodies Services for IRAK1
     GenScript Custom overexpressing Cell Line Services for IRAK1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for IRAK1 

     Regulatory tfbs in IRAK1 promoter
     Search Chromatin IP Primers for IRAK1
     RT2 qPCR Primer Assay in human, mouse, rat IRAK1
     GNC Network for IRAK1
     SABiosciences PCR Arrays including human, mouse, rat IRAK1
     Search Tocris compounds for IRAK1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IRAK1 antibodies
     IRAK1 proteins
     IRAK1 lysates
     Antibodies for IRAK1
     See all of Abcam's Antibodies, Kits and Proteins for IRAK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     IRAK1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IRAK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRAK1
     SwitchGear 3'UTR luciferase reporter plasmids for IRAK1
     SwitchGear Promoter luciferase reporter plasmids for IRAK1
     ThermoFisher Antibody for IRAK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRAK1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IRAK1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4