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Aliases for IQUB Gene

Aliases for IQUB Gene

  • IQ Motif And Ubiquitin Domain Containing 2 3

External Ids for IQUB Gene

Previous GeneCards Identifiers for IQUB Gene

  • GC07M122880
  • GC07M123092
  • GC07M117455

Summaries for IQUB Gene

GeneCards Summary for IQUB Gene

IQUB (IQ Motif And Ubiquitin Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQUB Gene

  • May play roles in cilia formation and/or maintenance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQUB Gene

Genomics for IQUB Gene

Regulatory Elements for IQUB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IQUB Gene

Start:
123,451,939 bp from pter
End:
123,535,077 bp from pter
Size:
83,139 bases
Orientation:
Minus strand

Genomic View for IQUB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IQUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQUB Gene

Proteins for IQUB Gene

  • Protein details for IQUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA54-IQUB_HUMAN
    Recommended name:
    IQ and ubiquitin-like domain-containing protein
    Protein Accession:
    Q8NA54
    Secondary Accessions:
    • A4D0X0
    • Q49AL6
    • Q4G189
    • Q5BJD9
    • Q6NUH6
    • Q8N9Y2

    Protein attributes for IQUB Gene

    Size:
    791 amino acids
    Molecular mass:
    92581 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQUB Gene

    Alternative splice isoforms for IQUB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQUB Gene

Proteomics data for IQUB Gene at MOPED

Post-translational modifications for IQUB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQUB Gene

No data available for DME Specific Peptides for IQUB Gene

Domains for IQUB Gene

Protein Domains for IQUB Gene

Suggested Antigen Peptide Sequences for IQUB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NA54

UniProtKB/Swiss-Prot:

IQUB_HUMAN :
  • Q8NA54
Domain:
  • Contains 1 IQ domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with IQUB: view

No data available for Gene Families for IQUB Gene

Function for IQUB Gene

Molecular function for IQUB Gene

UniProtKB/Swiss-Prot Function: May play roles in cilia formation and/or maintenance.

Gene Ontology (GO) - Molecular Function for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IQUB: view

Phenotypes for IQUB Gene

GenomeRNAi human phenotypes for IQUB:
genes like me logo Genes that share phenotypes with IQUB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IQUB Gene

Localization for IQUB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IQUB Gene COMPARTMENTS Subcellular localization image for IQUB gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with IQUB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQUB Gene

Pathways for IQUB Gene

SuperPathways for IQUB Gene

No Data Available

Gene Ontology (GO) - Biological Process for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway IEA --
GO:0060271 cilium morphogenesis IEA --
genes like me logo Genes that share ontologies with IQUB: view

No data available for Pathways by source for IQUB Gene

Transcripts for IQUB Gene

Unigene Clusters for IQUB Gene

IQ motif and ubiquitin domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQUB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IQUB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQUB Gene

No ASD Table

Relevant External Links for IQUB Gene

GeneLoc Exon Structure for
IQUB
ECgene alternative splicing isoforms for
IQUB

Expression for IQUB Gene

mRNA expression in normal human tissues for IQUB Gene

mRNA differential expression in normal tissues according to GTEx for IQUB Gene

This gene is overexpressed in Testis (25.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IQUB Gene

SOURCE GeneReport for Unigene cluster for IQUB Gene Hs.159650

genes like me logo Genes that share expressions with IQUB: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IQUB Gene

Orthologs for IQUB Gene

This gene was present in the common ancestor of animals.

Orthologs for IQUB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQUB 35
  • 99.41 (n)
  • 99.12 (a)
IQUB 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IQUB 36
  • 74 (a)
OneToOne
LOC536449 35
  • 83.5 (n)
  • 75.13 (a)
dog
(Canis familiaris)
Mammalia IQUB 35
  • 83.4 (n)
  • 76.93 (a)
IQUB 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iqub 35
  • 76.59 (n)
  • 69.99 (a)
Iqub 16
Iqub 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IQUB 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQUB 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iqub 35
  • 76.18 (n)
  • 70.95 (a)
chicken
(Gallus gallus)
Aves IQUB 35
  • 67.01 (n)
  • 58.22 (a)
IQUB 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQUB 36
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16226 35
tropical clawed frog
(Silurana tropicalis)
Amphibia iqub 35
  • 64.21 (n)
  • 57.52 (a)
Str.16333 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18526 35
iqub 36
  • 46 (a)
OneToOne
LOC100334576 35
  • 56.23 (n)
  • 48.52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002068 35
  • 40.97 (n)
  • 31.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13855 35
  • 44.23 (n)
  • 33.08 (a)
CG13855 36
  • 27 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.111 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for IQUB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQUB Gene

ENSEMBL:
Gene Tree for IQUB (if available)
TreeFam:
Gene Tree for IQUB (if available)

Paralogs for IQUB Gene

No data available for Paralogs for IQUB Gene

Variants for IQUB Gene

Sequence variations from dbSNP and Humsavar for IQUB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs940795 -- 123,458,331(+) TTTTT(A/T)AAAAA intron-variant
rs956021 -- 123,483,985(-) TACTT(A/G)TGGCC intron-variant
rs1357972 -- 123,459,169(+) CGGTA(C/T)TGAAA intron-variant
rs1404899 -- 123,506,745(+) CACAT(C/T)GCCCC intron-variant
rs1404900 -- 123,513,198(+) ACCCA(C/T)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQUB Gene

Variant ID Type Subtype PubMed ID
nsv524192 CNV Gain 19592680
nsv889125 CNV Gain 21882294
nsv889126 CNV Gain 21882294
nsv831116 CNV Gain+Loss 17160897
esv2646544 CNV Deletion 19546169

Relevant External Links for IQUB Gene

HapMap Linkage Disequilibrium report
IQUB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQUB Gene

Disorders for IQUB Gene

Relevant External Links for IQUB

Genetic Association Database (GAD)
IQUB
Human Genome Epidemiology (HuGE) Navigator
IQUB
genes like me logo Genes that share disorders with IQUB: view

No data available for UniProtKB/Swiss-Prot for IQUB Gene

Publications for IQUB Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3

Products for IQUB Gene

Sources for IQUB Gene

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