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Aliases for IQUB Gene

Aliases for IQUB Gene

  • IQ Motif And Ubiquitin Domain Containing 2 3 5

External Ids for IQUB Gene

Previous GeneCards Identifiers for IQUB Gene

  • GC07M122880
  • GC07M123092
  • GC07M117455

Summaries for IQUB Gene

GeneCards Summary for IQUB Gene

IQUB (IQ Motif And Ubiquitin Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQUB Gene

  • May play roles in cilia formation and/or maintenance.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQUB Gene

Genomics for IQUB Gene

Regulatory Elements for IQUB Gene

Enhancers for IQUB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F123533 1 ENCODE 7.8 +0.3 258 1.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 GLIS2 ELK1 KLF7 KDM4B NDUFA5 IQUB HYAL4 GC07M123458 RNU6-296P
GH07F123608 0.9 ENCODE 4.5 -74.4 -74440 1.1 HDAC1 PKNOX1 ATF1 NFRKB ELK1 CEBPB ZEB2 POLR2H MEF2D ZNF589 LMOD2 ASB15 IQUB NDUFA5 LOC102724555
GH07F123532 0.8 ENCODE 0.8 +2.1 2136 0.2 LEF1 SAP130 TAL1 ETV1 UBTF CHAMP1 GLIS2 POLR2A NCOR1 TRIM24 IQUB RNU6-296P GC07M123458
GH07F123528 0.9 Ensembl 0.4 +7.0 6977 0.2 HDGF HDAC1 NFRKB ZNF76 KLF17 ZNF2 GLIS2 KLF7 EGR2 SMARCA5 IQUB RNU6-296P GC07M123458
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQUB on UCSC Golden Path with GeneCards custom track

Promoters for IQUB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for IQUB Gene

123,452,181 bp from pter
123,535,077 bp from pter
82,897 bases
Minus strand

Genomic View for IQUB Gene

Genes around IQUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQUB Gene

Proteins for IQUB Gene

  • Protein details for IQUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ and ubiquitin-like domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A4D0X0
    • Q49AL6
    • Q4G189
    • Q5BJD9
    • Q6NUH6
    • Q8N9Y2

    Protein attributes for IQUB Gene

    791 amino acids
    Molecular mass:
    92581 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQUB Gene

    Alternative splice isoforms for IQUB Gene


neXtProt entry for IQUB Gene

Post-translational modifications for IQUB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQUB Gene

Domains & Families for IQUB Gene

Protein Domains for IQUB Gene

Suggested Antigen Peptide Sequences for IQUB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Contains 1 IQ domain.
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with IQUB: view

No data available for Gene Families for IQUB Gene

Function for IQUB Gene

Molecular function for IQUB Gene

UniProtKB/Swiss-Prot Function:
May play roles in cilia formation and/or maintenance.

Gene Ontology (GO) - Molecular Function for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IQUB: view
genes like me logo Genes that share phenotypes with IQUB: view

Animal Models for IQUB Gene

MGI Knock Outs for IQUB:
  • Iqub tm1.1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IQUB Gene

Localization for IQUB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQUB gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with IQUB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQUB Gene

Pathways & Interactions for IQUB Gene

No Data Available

Gene Ontology (GO) - Biological Process for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway IEA --
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IEA --
genes like me logo Genes that share ontologies with IQUB: view

No data available for Pathways by source and SIGNOR curated interactions for IQUB Gene

Transcripts for IQUB Gene

Unigene Clusters for IQUB Gene

IQ motif and ubiquitin domain containing:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQUB Gene

No ASD Table

Relevant External Links for IQUB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQUB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQUB Gene

mRNA differential expression in normal tissues according to GTEx for IQUB Gene

This gene is overexpressed in Testis (x25.8).

Protein differential expression in normal tissues from HIPED for IQUB Gene

This gene is overexpressed in Blymphocyte (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQUB Gene

Protein tissue co-expression partners for IQUB Gene

NURSA nuclear receptor signaling pathways regulating expression of IQUB Gene:


SOURCE GeneReport for Unigene cluster for IQUB Gene:

genes like me logo Genes that share expression patterns with IQUB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IQUB Gene

Orthologs for IQUB Gene

This gene was present in the common ancestor of animals.

Orthologs for IQUB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQUB 34 35
  • 99.41 (n)
(Bos Taurus)
Mammalia LOC536449 34
  • 83.5 (n)
  • 74 (a)
(Canis familiaris)
Mammalia IQUB 34 35
  • 83.4 (n)
(Mus musculus)
Mammalia Iqub 34 16 35
  • 76.59 (n)
(Rattus norvegicus)
Mammalia Iqub 34
  • 76.18 (n)
(Monodelphis domestica)
Mammalia IQUB 35
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia IQUB 35
  • 50 (a)
(Gallus gallus)
Aves IQUB 34 35
  • 67.01 (n)
(Anolis carolinensis)
Reptilia IQUB 35
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqub 34
  • 64.21 (n)
Str.16333 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16226 34
(Danio rerio)
Actinopterygii LOC100334576 34
  • 56.23 (n)
iqub 35
  • 46 (a)
Dr.18526 34
fruit fly
(Drosophila melanogaster)
Insecta CG13855 34 35
  • 44.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002068 34
  • 40.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.111 34
Species where no ortholog for IQUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQUB Gene

Gene Tree for IQUB (if available)
Gene Tree for IQUB (if available)

Paralogs for IQUB Gene

No data available for Paralogs for IQUB Gene

Variants for IQUB Gene

Sequence variations from dbSNP and Humsavar for IQUB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1525626 A colorectal cancer sample 123,452,915(+) ATGAG(C/G)GTTCA nc-transcript-variant, downstream-variant-500B, reference, missense
rs10081283 -- 123,534,310(+) AGATG(A/G)GATGC intron-variant, upstream-variant-2KB
rs10226761 -- 123,464,727(+) TTCCA(C/T)ATGGA intron-variant
rs10229868 -- 123,505,780(+) attaa(C/T)atttg intron-variant
rs10234745 -- 123,457,414(+) GCAGC(C/T)GCTTC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IQUB Gene

Variant ID Type Subtype PubMed ID
esv2646544 CNV deletion 19546169
esv3614855 CNV loss 21293372
esv3891198 CNV gain 25118596
nsv1075057 CNV deletion 25765185
nsv524192 CNV gain 19592680
nsv831116 CNV gain+loss 17160897
nsv970574 CNV duplication 23825009

Variation tolerance for IQUB Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQUB Gene

Disorders for IQUB Gene

Relevant External Links for IQUB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IQUB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQUB Gene

Publications for IQUB Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities. (PMID: 20602751) Docherty S.J. … Plomin R. (BMC Genet. 2010) 3 64

Products for IQUB Gene

Sources for IQUB Gene

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