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Aliases for IQUB Gene

Aliases for IQUB Gene

  • IQ Motif And Ubiquitin Domain Containing 2 3 5

External Ids for IQUB Gene

Previous GeneCards Identifiers for IQUB Gene

  • GC07M122880
  • GC07M123092
  • GC07M117455

Summaries for IQUB Gene

GeneCards Summary for IQUB Gene

IQUB (IQ Motif And Ubiquitin Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQUB Gene

  • May play roles in cilia formation and/or maintenance.

Additional gene information for IQUB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQUB Gene

Genomics for IQUB Gene

GeneHancer (GH) Regulatory Elements for IQUB Gene

Promoters and enhancers for IQUB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I123533 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.9 +0.3 258 1.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B GLIS2 IQUB NDUFA5 HYAL4 RNU6-296P GC07M123458
GH07I123532 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +2.3 2276 1.2 ATF1 TCF12 POLR2B GLIS2 ATF7 NCOA1 REST ZNF592 GMEB1 SMARCA4 IQUB GC07M123458 RNU6-296P
GH07I123608 Enhancer 1 ENCODE dbSUPER 4.5 -74.4 -74440 1.1 HDAC1 PKNOX1 ATF1 NFRKB ZBTB40 ZNF766 ATF7 CEBPB ZEB2 ZNF592 ENSG00000272686 LMOD2 ASB15 IQUB NDUFA5 LOC102724555
GH07I123611 Enhancer 0.6 dbSUPER 5 -76.9 -76856 1 MEIS2 GATAD2A PKNOX1 ZNF740 HLF BACH1 EP300 ZNF830 HMBOX1 HNF4A LMOD2 ASB15 NDUFA5 IQUB LOC102724555
GH07I123602 Enhancer 0.6 dbSUPER 4.8 -67.8 -67814 0.4 MAFG BACH1 ZMYM3 ZNF316 HMBOX1 NFE2 EMSY MAFK NDUFA5 LOC102724555 LMOD2 ASB15 IQUB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQUB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQUB gene promoter:

Genomic Locations for IQUB Gene

Genomic Locations for IQUB Gene
82,897 bases
Minus strand

Genomic View for IQUB Gene

Genes around IQUB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQUB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQUB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQUB Gene

Proteins for IQUB Gene

  • Protein details for IQUB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ and ubiquitin-like domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A4D0X0
    • Q49AL6
    • Q4G189
    • Q5BJD9
    • Q6NUH6
    • Q8N9Y2

    Protein attributes for IQUB Gene

    791 amino acids
    Molecular mass:
    92581 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQUB Gene

    Alternative splice isoforms for IQUB Gene


neXtProt entry for IQUB Gene

Post-translational modifications for IQUB Gene

No Post-translational modifications

No data available for DME Specific Peptides for IQUB Gene

Domains & Families for IQUB Gene

Gene Families for IQUB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQUB Gene

Suggested Antigen Peptide Sequences for IQUB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQUB: view

No data available for UniProtKB/Swiss-Prot for IQUB Gene

Function for IQUB Gene

Molecular function for IQUB Gene

UniProtKB/Swiss-Prot Function:
May play roles in cilia formation and/or maintenance.

Phenotypes From GWAS Catalog for IQUB Gene

Gene Ontology (GO) - Molecular Function for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IQUB: view
genes like me logo Genes that share phenotypes with IQUB: view

Animal Models for IQUB Gene

MGI Knock Outs for IQUB:
  • Iqub tm1.1(KOMP)Vlcg

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IQUB Gene

Localization for IQUB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQUB gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with IQUB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQUB Gene

Pathways & Interactions for IQUB Gene

No Data Available

Gene Ontology (GO) - Biological Process for IQUB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway IEA --
GO:0030030 cell projection organization IEA --
GO:0060271 cilium assembly IEA --
genes like me logo Genes that share ontologies with IQUB: view

No data available for Pathways by source and SIGNOR curated interactions for IQUB Gene

Drugs & Compounds for IQUB Gene

No Compound Related Data Available

Transcripts for IQUB Gene

Unigene Clusters for IQUB Gene

IQ motif and ubiquitin domain containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQUB Gene

No ASD Table

Relevant External Links for IQUB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQUB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQUB Gene

mRNA differential expression in normal tissues according to GTEx for IQUB Gene

This gene is overexpressed in Testis (x25.8).

Protein differential expression in normal tissues from HIPED for IQUB Gene

This gene is overexpressed in Blymphocyte (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQUB Gene

Protein tissue co-expression partners for IQUB Gene

NURSA nuclear receptor signaling pathways regulating expression of IQUB Gene:


SOURCE GeneReport for Unigene cluster for IQUB Gene:

genes like me logo Genes that share expression patterns with IQUB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQUB Gene

Orthologs for IQUB Gene

This gene was present in the common ancestor of animals.

Orthologs for IQUB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQUB 33 34
  • 99.41 (n)
(Bos Taurus)
Mammalia LOC536449 33
  • 83.5 (n)
  • 74 (a)
(Canis familiaris)
Mammalia IQUB 33 34
  • 83.4 (n)
(Mus musculus)
Mammalia Iqub 33 16 34
  • 76.59 (n)
(Rattus norvegicus)
Mammalia Iqub 33
  • 76.18 (n)
(Monodelphis domestica)
Mammalia IQUB 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia IQUB 34
  • 50 (a)
(Gallus gallus)
Aves IQUB 33 34
  • 67.01 (n)
(Anolis carolinensis)
Reptilia IQUB 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqub 33
  • 64.21 (n)
Str.16333 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16226 33
(Danio rerio)
Actinopterygii LOC100334576 33
  • 56.23 (n)
iqub 34
  • 46 (a)
Dr.18526 33
fruit fly
(Drosophila melanogaster)
Insecta CG13855 33 34
  • 44.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002068 33
  • 40.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.111 33
Species where no ortholog for IQUB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQUB Gene

Gene Tree for IQUB (if available)
Gene Tree for IQUB (if available)

Paralogs for IQUB Gene

No data available for Paralogs for IQUB Gene

Variants for IQUB Gene

Sequence variations from dbSNP and Humsavar for IQUB Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1525626 A colorectal cancer sample 123,452,915(-) C/G/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000037261 -- 123,462,020(-) TTTAATTTA/TTTA intron_variant
rs1000060310 -- 123,481,940(-) T/C intron_variant
rs1000063963 -- 123,533,723(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000076885 -- 123,465,667(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQUB Gene

Variant ID Type Subtype PubMed ID
esv2646544 CNV deletion 19546169
esv3614855 CNV loss 21293372
esv3891198 CNV gain 25118596
nsv1075057 CNV deletion 25765185
nsv524192 CNV gain 19592680
nsv831116 CNV gain+loss 17160897
nsv970574 CNV duplication 23825009

Variation tolerance for IQUB Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQUB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQUB Gene

Disorders for IQUB Gene

Additional Disease Information for IQUB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IQUB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQUB Gene

Publications for IQUB Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for IQUB Gene

Sources for IQUB Gene

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