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Aliases for IQSEC3 Gene

Aliases for IQSEC3 Gene

  • IQ Motif And Sec7 Domain 3 2 3
  • KIAA1110 4

External Ids for IQSEC3 Gene

Previous GeneCards Identifiers for IQSEC3 Gene

  • GC12P000057
  • GC12P000176

Summaries for IQSEC3 Gene

GeneCards Summary for IQSEC3 Gene

IQSEC3 (IQ Motif And Sec7 Domain 3) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is ENSG00000268465.

UniProtKB/Swiss-Prot for IQSEC3 Gene

  • Acts as a guanine nucleotide exchange factor (GEF) for ARF1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQSEC3 Gene

Genomics for IQSEC3 Gene

Regulatory Elements for IQSEC3 Gene

Genomic Location for IQSEC3 Gene

66,765 bp from pter
178,460 bp from pter
111,696 bases
Plus strand

Genomic View for IQSEC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IQSEC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQSEC3 Gene

Proteins for IQSEC3 Gene

  • Protein details for IQSEC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ motif and SEC7 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A6NIF2
    • A6NKV9
    • Q8TB43

    Protein attributes for IQSEC3 Gene

    1182 amino acids
    Molecular mass:
    127621 Da
    Quaternary structure:
    • Interacts with DLG1 and DLG4.

    Alternative splice isoforms for IQSEC3 Gene


neXtProt entry for IQSEC3 Gene

Proteomics data for IQSEC3 Gene at MOPED

Post-translational modifications for IQSEC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQSEC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQSEC3 Gene

Domains & Families for IQSEC3 Gene

Protein Domains for IQSEC3 Gene

Suggested Antigen Peptide Sequences for IQSEC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Belongs to the BRAG family.
  • Contains 1 IQ domain.
  • Contains 1 PH domain.
  • Contains 1 SEC7 domain.
  • Belongs to the BRAG family.
genes like me logo Genes that share domains with IQSEC3: view

No data available for Gene Families for IQSEC3 Gene

Function for IQSEC3 Gene

Molecular function for IQSEC3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a guanine nucleotide exchange factor (GEF) for ARF1.

Gene Ontology (GO) - Molecular Function for IQSEC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IQSEC3: view

Phenotypes for IQSEC3 Gene

GenomeRNAi human phenotypes for IQSEC3:
genes like me logo Genes that share phenotypes with IQSEC3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQSEC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IQSEC3 Gene

Localization for IQSEC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IQSEC3 Gene


Subcellular locations from

Jensen Localization Image for IQSEC3 Gene COMPARTMENTS Subcellular localization image for IQSEC3 gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IQSEC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 NOT trans-Golgi network IBA --
GO:0045211 postsynaptic membrane IEA --
GO:0060077 inhibitory synapse IEA --
genes like me logo Genes that share ontologies with IQSEC3: view

Pathways & Interactions for IQSEC3 Gene

SuperPathways for IQSEC3 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with IQSEC3: view

Pathways by source for IQSEC3 Gene

1 KEGG pathway for IQSEC3 Gene

Interacting Proteins for IQSEC3 Gene

Gene Ontology (GO) - Biological Process for IQSEC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 NOT vesicle-mediated transport IBA --
GO:0030036 actin cytoskeleton organization IBA --
GO:0032012 regulation of ARF protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with IQSEC3: view

No data available for SIGNOR curated interactions for IQSEC3 Gene

Drugs & Compounds for IQSEC3 Gene

(3) Drugs for IQSEC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with IQSEC3: view

Transcripts for IQSEC3 Gene

Unigene Clusters for IQSEC3 Gene

IQ motif and Sec7 domain 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQSEC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQSEC3 Gene

No ASD Table

Relevant External Links for IQSEC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQSEC3 Gene

mRNA expression in normal human tissues for IQSEC3 Gene

mRNA differential expression in normal tissues according to GTEx for IQSEC3 Gene

This gene is overexpressed in Brain - Cerebellum (x7.4), Brain - Cerebellar Hemisphere (x6.3), Brain - Cortex (x5.7), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for IQSEC3 Gene

This gene is overexpressed in Fetal gut (28.3), Frontal cortex (13.6), and Retina (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQSEC3 Gene

SOURCE GeneReport for Unigene cluster for IQSEC3 Gene Hs.536319

mRNA Expression by UniProt/SwissProt for IQSEC3 Gene

Tissue specificity: Expressed specifically in the adult brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor in glioma cells.
genes like me logo Genes that share expression patterns with IQSEC3: view

Protein tissue co-expression partners for IQSEC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IQSEC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IQSEC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IQSEC3 35
  • 87.11 (n)
  • 85.15 (a)
  • 85 (a)
(Canis familiaris)
Mammalia IQSEC3 35
  • 89.25 (n)
  • 88.79 (a)
  • 88 (a)
(Mus musculus)
Mammalia Iqsec3 35
  • 84.87 (n)
  • 85.73 (a)
Iqsec3 16
Iqsec3 36
  • 86 (a)
(Pan troglodytes)
Mammalia IQSEC3 35
  • 95.93 (n)
  • 95.01 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Iqsec3 35
  • 84.5 (n)
  • 85.47 (a)
(Monodelphis domestica)
Mammalia IQSEC3 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia IQSEC3 36
  • 49 (a)
(Gallus gallus)
Aves IQSEC3 35
  • 73.88 (n)
  • 77.3 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia IQSEC3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqsec3 35
  • 66.6 (n)
  • 67.72 (a)
(Danio rerio)
Actinopterygii LOC798516 35
  • 59.49 (n)
  • 63.23 (a)
iqsec3a 36
  • 55 (a)
iqsec3b 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta siz 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for IQSEC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQSEC3 Gene

Gene Tree for IQSEC3 (if available)
Gene Tree for IQSEC3 (if available)

Paralogs for IQSEC3 Gene

(5) SIMAP similar genes for IQSEC3 Gene using alignment to 1 proteins: Pseudogenes for IQSEC3 Gene

genes like me logo Genes that share paralogs with IQSEC3: view

Variants for IQSEC3 Gene

Sequence variations from dbSNP and Humsavar for IQSEC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_061789 -
rs563231849 -- 84,652(+) GTACA(C/T)ATCTT intron-variant
rs66580338 -- 90,601(+) AATGC(-/A)CTTGG intron-variant
rs55672031 -- 79,236(+) CCCCC(-/C)GCCTA intron-variant
rs36126748 -- 129,607(+) AGGAA(-/A)TAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQSEC3 Gene

Variant ID Type Subtype PubMed ID
nsv8882 CNV Gain+Loss 18304495
nsv428269 CNV Gain+Loss 18775914
nsv832301 CNV Gain+Loss 17160897
esv24198 CNV Gain+Loss 19812545
nsv821041 CNV Duplication 20802225
nsv826169 CNV Gain 20364138
nsv898552 CNV Gain 21882294
nsv832302 CNV Gain 17160897
nsv898553 CNV Gain 21882294
dgv1336n71 CNV Gain 21882294
nsv468943 CNV Gain 19166990
nsv470252 CNV Gain 18288195
nsv826170 CNV Gain 20364138
nsv567 CNV Insertion 18451855
esv1788942 CNV Insertion 17803354
nsv898556 CNV Gain 21882294
nsv898557 CNV Gain 21882294
esv2661929 CNV Deletion 23128226
nsv826171 CNV Gain 20364138
nsv826172 CNV Gain 20364138
nsv898558 CNV Gain 21882294
nsv568 CNV Insertion 18451855
esv1944737 CNV Deletion 18987734
esv2668905 CNV Deletion 23128226
dgv87n21 CNV Loss 19592680
nsv898559 CNV Loss 21882294
nsv898560 CNV Loss 21882294
esv2445422 CNV Insertion 19546169
nsv468947 CNV Gain 19166990
nsv898561 CNV Gain 21882294
nsv898562 CNV Loss 21882294

Variation tolerance for IQSEC3 Gene

Residual Variation Intolerance Score: 51.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQSEC3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQSEC3 Gene

Disorders for IQSEC3 Gene

Relevant External Links for IQSEC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IQSEC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQSEC3 Gene

Publications for IQSEC3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 67
  2. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PMID: 22566498) Turner S.T. … Boerwinkle E. (Hypertension 2012) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1. (PMID: 17981261) Hattori Y. … Toda M. (Biochem. Biophys. Res. Commun. 2007) 67
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 67

Products for IQSEC3 Gene

Sources for IQSEC3 Gene

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