Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IQSEC1 Gene

protein-coding   GIFtS: 63
GCID: GC03M012938

IQ Motif And Sec7 Domain 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
IQ Motif And Sec7 Domain 11 2     ADP-Ribosylation Factors Guanine Nucleotide-Exchange Protein 22 3
Brefeldin A-Resistant ARF-GEF21 2     KIAA07633 5
Brefeldin-Resistant Arf-GEF 2 Protein2 3     ARF-GEP1002
ARFGEP1002 3     GEP1002
BRAG22 3     IQ Motif And SEC7 Domain-Containing Protein 12
ADP-Ribosylation Factors Guanine Nucleotide-Exchange Protein 1002 3     

External Ids:    HGNC: 291121   Entrez Gene: 99222   Ensembl: ENSG000001447117   OMIM: 6101665   UniProtKB: Q6DN903   

Export aliases for IQSEC1 gene to outside databases

Previous GC identifers: GC03M012916 GC03M012872


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IQSEC1 Gene:
IQSEC1 (IQ motif and Sec7 domain 1) is a protein-coding gene. Diseases associated with IQSEC1 include intracranial aneurysm, and lung adenocarcinoma. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90
Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function
preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin

Gene Wiki entry for IQSEC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the IQSEC1 gene promoter:
         AML1a   Lmo2   Tal-1beta   YY1   Egr-2   PPAR-alpha   Nkx6-1   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQSEC1 promoter sequence
   Search Chromatin IP Primers for IQSEC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQSEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

IQSEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQSEC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M012938:  view genomic region     (about GC identifiers)

Start:
12,938,719 bp from pter      End:
13,114,617 bp from pter
Size:
175,899 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90 (See protein sequence)
Recommended Name: IQ motif and SEC7 domain-containing protein 1  
Size: 963 amino acids; 108314 Da
Subunit: Interacts with ARF6
2 PDB 3D structures from and Proteopedia for IQSEC1:
3QWM (3D)        4C0A (3D)    
Secondary accessions: O94863 Q96D85
Alternative splicing: 2 isoforms:  Q6DN90-1   Q6DN90-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQSEC1: NX_Q6DN90

Explore proteomics data for IQSEC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IQSEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127854.1  NP_055684.3  

    ENSEMBL proteins: 
     ENSP00000273221   ENSP00000397811   ENSP00000402299  

    IQSEC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IQSEC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IQSEC1
    GenScript Custom Purified and Recombinant Proteins Services for IQSEC1
    Novus Biologicals IQSEC1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IQSEC1

    IQSEC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for IQSEC1
    OriGene Custom Antibody Services for IQSEC1
    Novus Biologicals IQSEC1 Antibody
    Abcam antibodies for IQSEC1 (Q6DN90 , Q6DN90)
    Cloud-Clone Corp. Antibodies for IQSEC1
    Search ThermoFisher Antibodies for IQSEC1
    LSBio Antibodies in human, mouse, rat for IQSEC1

    IQSEC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IQSEC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IQSEC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IQSEC1
    Cloud-Clone Corp. CLIAs for IQSEC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 Sec7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7_dom
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q6DN90

    ProtoNet protein and cluster: Q6DN90

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90
    Similarity: Belongs to the BRAG family
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    IQSEC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IQEC1_HUMAN, Q6DN90
    Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function
    preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005515protein binding ----
         
    IQSEC1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for IQSEC1:
     Decreased influenza A virus in  Increased G2M DNA content  Increased cell size  Increased gamma-H2AX phosphory 
     Increased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Iqsec1):
     nervous system 

    IQSEC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IQSEC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IQSEC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IQSEC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IQSEC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target IQSEC1:
    hsa-mir-378a-5p (MIRT044004), hsa-mir-589-3p (MIRT040506), hsa-mir-92a-1-5p (MIRT038915)

    Block miRNA regulation of human, mouse, rat IQSEC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IQSEC1 (see all 95):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3138 hsa-miR-3074-3p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidIQSEC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IQSEC1
    Predesigned siRNA for gene silencing in human, mouse, rat IQSEC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IQSEC1

    Clone
    Products:
         
    OriGene clones in human, mouse for IQSEC1 (see all 14)
    OriGene ORF clones in mouse, rat for IQSEC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IQSEC1 (NM_014869)
    Sino Biological Human cDNA Clone for IQSEC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IQSEC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQSEC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IQSEC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for IQSEC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQSEC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IQEC1_HUMAN, Q6DN90: Cytoplasm. Nucleus. Note=At steady state, may be preferentially cytosolic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005802NOT trans-Golgi network IBA--
    GO:0030054cell junction IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    IQSEC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IQSEC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis
    2Arf6 signaling events
    Arf6 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for IQSEC1
        Arf6 signaling events



    1 Kegg Pathway  (Kegg details for IQSEC1):
        Endocytosis


    IQSEC1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IQSEC1
    Interactions:

        Search GeneGlobe Interaction Network for IQSEC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for IQSEC1 (Q6DN903 ENSP000002732214) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516173, ENSP000003589974I2D: score=1 STRING: ENSP00000358997
    IRAK2O431873, ENSP000002564584I2D: score=1 STRING: ENSP00000256458
    IRF7Q929853, ENSP000003294114I2D: score=1 STRING: ENSP00000329411
    DLG4P783523I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030036actin cytoskeleton organization IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--
    GO:0043087regulation of GTPase activity IBA--

    IQSEC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IQSEC1 (IQEC1)

    3 HMDB Compounds for IQSEC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IQSEC1 gene (2 alternative transcripts): 
    NM_001134382.2  NM_014869.5  

    Unigene Cluster for IQSEC1:

    IQ motif and Sec7 domain 1
    Hs.475506  [show with all ESTs]
    Unigene Representative Sequence: NM_001134382
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273221(uc003bxt.2 uc003bxu.3 uc011auw.1) ENST00000450726
    ENST00000429247 ENST00000473088 ENST00000474467
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IQSEC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IQSEC1 (see all 95):
    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3138 hsa-miR-3074-3p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidIQSEC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IQSEC1
    Predesigned siRNA for gene silencing in human, mouse, rat IQSEC1
    Clone
    Products:
         
    OriGene clones in human, mouse for IQSEC1 (see all 14)
    OriGene ORF clones in mouse, rat for IQSEC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IQSEC1 (NM_014869)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IQSEC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQSEC1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IQSEC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IQSEC1
      QuantiTect SYBR Green Assays in human, mouse, rat IQSEC1
      QuantiFast Probe-based Assays in human, mouse, rat IQSEC1

    Additional mRNA sequence: 

    AB018306.1 AF055004.1 AK294525.1 AY653734.1 BC008088.1 BC010267.1 BC024645.1 

    14 DOTS entries:

    DT.448908  DT.95174681  DT.100842421  DT.120880894  DT.92436701  DT.120880857  DT.99955516  DT.97837288 
    DT.120880980  DT.95177739  DT.120880962  DT.92436688  DT.95174679  DT.92436673 

    Selected AceView cDNA sequences (see all 310):

    BQ880774 AI640694 CD675948 BQ640234 AI699450 CF264894 AA604519 AW150891 
    BE672812 AA811586 AI127134 BQ224157 NM_014869 AW206990 AL602436 AA004577 
    AW029426 AY653734 F07160 BF592927 AW510769 BC010267 T31764 BU680510 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IQSEC1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                              -     -         
    SP4:                    -                                                                                                         
    SP5:        -     -     -                                                                                                         


    ECgene alternative splicing isoforms for IQSEC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IQSEC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGAAATC
    IQSEC1 Expression
    About this image


    IQSEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Neural Tube (Nervous System)
             Telencephalon
    IQSEC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IQSEC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475506

    UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90
    Tissue specificity: Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was
    also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis

        Custom PCR Arrays for IQSEC1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IQSEC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IQSEC1
    QuantiTect SYBR Green Assays in human, mouse, rat IQSEC1
    QuantiFast Probe-based Assays in human, mouse, rat IQSEC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQSEC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for IQSEC1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqsec11 , 5 IQ motif and Sec7 domain 11, 5 87.91(n)1
    94.25(a)1
      6 (40.16 cM)5
    2322271  NM_001134384.11  NP_001127856.11 
     906595985 
    chicken
    (Gallus gallus)
    Aves LOC4159761 IQ motif and Sec7 domain 1-like 73.76(n)
    86.79(a)
      415976  XM_004944535.1  XP_004944592.1 
    lizard
    (Anolis carolinensis)
    Reptilia IQSEC16
    IQ motif and Sec7 domain 1
    70(a)
    1 ↔ 1
    2(159547575-159601612)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ058948.12   -- 79.08(n)    BJ058948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001487361 IQ motif and SEC7 domain-containing protein 1-like 74.03(n)
    80.98(a)
      100148736  XM_005169330.1  XP_005169387.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta siz6
    schizo
    27(a)
    1 → many
    3L(21027635-21068544)


    ENSEMBL Gene Tree for IQSEC1 (if available)
    TreeFam Gene Tree for IQSEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IQSEC1 gene
    CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  CYTH42  IQSEC22  
    CYTH12  FBXO82  
    8 SIMAP similar genes for IQSEC1 using alignment to 4 protein entries:     IQEC1_HUMAN (see all proteins):
    PSCD2L    IQSEC2    CYTH2    CYTH1    CYTH3    FLJ00017
    MST051    IQSEC3

    IQSEC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IQSEC1 (see all 3849)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs748924101,2
    C--12938087(+) AGAACA/GTCTTT 2 -- ds50010--------
    rs1831863281,2
    --12938093(+) TCTTTC/TAATCA 2 -- ds50010--------
    rs111286221,2
    --12938140(+) TGGTCA/CCCAAA 2 -- ds50010--------
    rs1875454521,2
    --12938193(+) AGTTCA/CTTTTA 2 -- ds50010--------
    rs1919684701,2
    --12938257(+) AAAGGA/GGAAAT 2 -- ds50010--------
    rs1437437421,2
    --12938263(+) GAAATC/TGCAGA 2 -- ds50010--------
    rs1147948331,2
    F--12938264(+) AAATCG/ACAGAA 2 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1850030791,2
    --12938678(+) GGCCAA/CCAGGG 2 -- ut310--------
    rs1155322191,2
    C,F--12938762(+) ACAACC/TATGGT 2 -- ut311Minor allele frequency- T:0.02NA 120
    rs1886447541,2
    --12938774(+) TTACAC/TTGATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IQSEC1 (12938719 - 13114617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IQSEC1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999756CNV Deletion20482838
    esv2724937CNV Deletion23290073
    nsv460442CNV Loss19166990
    nsv876542CNV Loss21882294
    dgv5108n71CNV Loss21882294
    nsv834617CNV Loss17160897
    nsv470405CNV Loss18288195
    esv33247CNV Loss17666407
    nsv876545CNV Loss21882294
    nsv460435CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IQSEC1
    DNA2.0 Custom Variant and Variant Library Synthesis for IQSEC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610166    OMIM disorders: --

    10 diseases for IQSEC1:    
    About MalaCards
    intracranial aneurysm    lung adenocarcinoma    type 1 diabetes    pancreatic cancer
    cervicitis    adenocarcinoma    pancreatitis    alzheimer's disease
    breast cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for IQSEC1:
    Intracranial aneurysm

    IQSEC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IQSEC1
    Human Genome Epidemiology (HuGE) Navigator: IQSEC1 (1 document)

    Export disorders for IQSEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IQSEC1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with IQSEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. (PubMed id 20613766)1, 4 Akiyama K....Inoue I. (J. Hum. Genet. 2010)
    3. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. (PubMed id 16461286)1, 2 Dunphy J.L....Casanova J.E. (Curr. Biol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP- ribosylation factor 6. (PubMed id 11226253)1, 2 Someya A.... Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    6. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    7. GEP100 regulates epidermal growth factor-induced MDA-MB-231 breast cancer cell invasion through the activation of Arf6/ERK/uPAR signaling pathway. (PubMed id 23747719)1 Hu Z....Gu L. (Exp. Cell Res. 2013)
    8. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    9. The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site. (PubMed id 22613714)1 Jian X....Randazzo P.A. (J. Biol. Chem. 2012)
    10. BRAG2/GEP100/IQSec1 interacts with clathrin and regulates I+5I^1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5). (PubMed id 22815487)1 Moravec R....Casanova J.E. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9922 HGNC: 29112 AceView: IQSEC1 Ensembl:ENSG00000144711 euGenes: HUgn9922
    ECgene: IQSEC1 Kegg: 9922 H-InvDB: IQSEC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0763

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IQSEC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IQSEC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IQSEC1 gene:
    Search GeneIP for patents involving IQSEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IQSEC1   OriGene RNAi products in human, mouse, rat for IQSEC1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IQSEC1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IQSEC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for IQSEC1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IQSEC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IQSEC1   OriGene Custom Protein Services for IQSEC1  

     
     
     Block miRNA regulation of human, mouse, rat IQSEC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IQSEC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQSEC1 Predesigned siRNA for gene silencing in human, mouse, rat IQSEC1
     QuantiFast Probe-based Assays in human, mouse, rat IQSEC1 QuantiTect SYBR Green Assays in human, mouse, rat IQSEC1
     Custom PCR Arrays for IQSEC1 Search Chromatin IP Primers for IQSEC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IQSEC1  Search GeneGlobe Interaction Network for IQSEC1
     Regulatory tfbs in IQSEC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IQSEC1 GenScript cDNA clones with any tag delivered in your preferred vector for IQSEC1
     GenScript Custom Assay Services for IQSEC1 GenScript Custom overexpressing Cell Line Services for IQSEC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IQSEC1 (IQEC1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IQSEC1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IQSEC1 antibodies
     IQSEC1 proteins
     Antibodies for IQSEC1
     See all of Abcam's Antibodies, Kits and Proteins for IQSEC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IQSEC1
     Antibodies for IQSEC1
     ELISAs for IQSEC1
     CLIAs for IQSEC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for IQSEC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQSEC1
     SwitchGear 3'UTR luciferase reporter plasmids for IQSEC1
     SwitchGear Promoter luciferase reporter plasmids for IQSEC1
     Search ThermoFisher Antibodies for IQSEC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQSEC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IQSEC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IQSEC1
     LSBio Antibodies in human, mouse, rat for IQSEC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IQSEC1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4