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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQSEC1 Gene

protein-coding   GIFtS: 63
GCID: GC03M012938

IQ Motif And Sec7 Domain 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IQ Motif And Sec7 Domain 11 2     ADP-Ribosylation Factors Guanine Nucleotide-Exchange Protein 22 3
Brefeldin A-Resistant ARF-GEF21 2     ARF-GEP1002
Brefeldin-Resistant Arf-GEF 2 Protein2 3     GEP1002
ARFGEP1002 3     IQ Motif And SEC7 Domain-Containing Protein 12
BRAG22 3     KIAA07633
ADP-Ribosylation Factors Guanine Nucleotide-Exchange Protein 1002 3     

External Ids:    HGNC: 291121   Entrez Gene: 99222   Ensembl: ENSG000001447117   OMIM: 6101665   UniProtKB: Q6DN903   

Export aliases for IQSEC1 gene to outside databases

Previous GC identifers: GC03M012916 GC03M012872


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IQSEC1 Gene: 
IQSEC1 (IQ motif and Sec7 domain 1) is a protein-coding gene. Diseases associated with IQSEC1 include intracranial aneurysm, and lung adenocarcinoma. GO annotations related to this gene include phospholipid binding and ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH3.

UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90
Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function
preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin

Gene Wiki entry for IQSEC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQSEC1 gene promoter:
         AML1a   Lmo2   Tal-1beta   YY1   Egr-2   PPAR-alpha   Nkx6-1   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQSEC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IQSEC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQSEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

IQSEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQSEC1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M012938:  view genomic region     (about GC identifiers)

Start:
12,938,719 bp from pter      End:
13,114,617 bp from pter
Size:
175,899 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90 (See protein sequence)
Recommended Name: IQ motif and SEC7 domain-containing protein 1  
Size: 963 amino acids; 108314 Da
Subunit: Interacts with ARF6
Subcellular location: Cytoplasm. Nucleus. Note=At steady state, may be preferentially cytosolic
1 PDB 3D structure from and Proteopedia for IQSEC1:
3QWM (3D)    
Secondary accessions: O94863 Q96D85
Alternative splicing: 2 isoforms:  Q6DN90-1   Q6DN90-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQSEC1: NX_Q6DN90

Explore proteomics data for IQSEC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6DN90

  • IQSEC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IQSEC1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001127854.1  NP_055684.3  

    ENSEMBL proteins: 
     ENSP00000273221   ENSP00000397811   ENSP00000402299  

    Human Recombinant Protein Products for IQSEC1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IQSEC1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005802NOT trans-Golgi network IBA--
    GO:0030054cell junction IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    IQSEC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR023394 SEC7_alpha_orthog
     IPR011993 PH_like_dom
     IPR000904 Sec7
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q6DN90

    ProtoNet protein and cluster: Q6DN90

    2 Blocks protein domains:
    IPB000904 SEC7-like domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90
    Similarity: Belongs to the BRAG family
    Similarity: Contains 1 IQ domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SEC7 domain


    IQSEC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IQEC1_HUMAN, Q6DN90
    Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function
    preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005086ARF guanyl-nucleotide exchange factor activity IBA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    IQSEC1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for IQSEC1:
     Decreased influenza A virus in  Increased G2M DNA content  Increased cell size  Increased gamma-H2AX phosphory 
     Increased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Iqsec1):
     nervous system 

    IQSEC1 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidIQSEC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IQSEC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis
    2Arf6 signaling events
    Arf6 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for IQSEC1
        Arf6 signaling events



    1         Kegg Pathway  (Kegg details for IQSEC1):
        Endocytosis


    IQSEC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQSEC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/10 Interacting proteins for IQSEC1 (Q6DN903 ENSP000002732214) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1P516173, ENSP000003589974I2D: score=1 STRING: ENSP00000358997
    IRAK2O431873, ENSP000002564584I2D: score=1 STRING: ENSP00000256458
    IRF7Q929853, ENSP000003294114I2D: score=1 STRING: ENSP00000329411
    DLG4P783523I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192NOT vesicle-mediated transport IBA--
    GO:0030036actin cytoskeleton organization IBA--
    GO:0032012regulation of ARF protein signal transduction IEA--

    IQSEC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQSEC1 (IQEC1)

    3 HMDB Compounds for IQSEC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about IQSEC1 / IQEC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IQSEC1 gene (2 alternative transcripts): 
    NM_001134382.2  NM_014869.5  

    Unigene Cluster for IQSEC1:

    IQ motif and Sec7 domain 1
    Hs.475506  [show with all ESTs]
    Unigene Representative Sequence: NM_001134382
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273221(uc003bxt.2 uc003bxu.3 uc011auw.1) ENST00000450726
    ENST00000429247 ENST00000473088 ENST00000474467
    miRNA
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    hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-128 hsa-miR-374a hsa-miR-3138 hsa-miR-3074-3p hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidIQSEC1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB018306.1 AF055004.1 AK294525.1 AY653734.1 BC008088.1 BC010267.1 BC024645.1 

    14 DOTS entries:

    DT.448908  DT.95174681  DT.100842421  DT.120880894  DT.92436701  DT.120880857  DT.99955516  DT.97837288 
    DT.120880980  DT.95177739  DT.120880962  DT.92436688  DT.95174679  DT.92436673 

    24/310 AceView cDNA sequences (see all 310):

    AI127134 BM783843 BQ640234 AA811586 CA436313 T31764 BF941897 AW029426 
    BF727113 AY653734 AW206990 F07160 AI640694 BQ004209 AA004577 CF141494 
    BP376281 BQ186726 BU680510 AI269207 AI699450 AW510769 BC010267 CF264894 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IQSEC1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                              -     -         
    SP4:                    -                                                                                                         
    SP5:        -     -     -                                                                                                         


    ECgene alternative splicing isoforms for IQSEC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQSEC1 expression in normal human tissues (normalized intensities)      IQSEC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGAAATC
    IQSEC1 Expression
    About this image


    IQSEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Neural Tube (Nervous System)
             Telencephalon

    See IQSEC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQSEC1

    SOURCE GeneReport for Unigene cluster: Hs.475506

    UniProtKB/Swiss-Prot: IQEC1_HUMAN, Q6DN90
    Tissue specificity: Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was
    also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis

        SABiosciences Custom PCR Arrays for IQSEC1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQSEC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IQSEC1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqsec11 , 5 IQ motif and Sec7 domain 11, 5 87.91(n)1
    94.25(a)1
      6 (40.16 cM)5
    2322271  NM_001134384.11  NP_001127856.11 
     906595985 
    chicken
    (Gallus gallus)
    Aves IQSEC11 IQ motif and Sec7 domain 1 74.79(n)
    88.18(a)
      415975  XM_414318.3  XP_414318.3 
    lizard
    (Anolis carolinensis)
    Reptilia IQSEC16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    2(159547575-159601612)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ058948.12   -- 79.08(n)    BJ058948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001487361 IQ motif and SEC7 domain-containing protein 1-like 74.06(n)
    81.76(a)
      100148736  XM_001922288.3  XP_001922323.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta siz1 schizo 49.21(n)
    42.79(a)
      40327  NM_168881.2  NP_730594.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M02B7.51 Protein M02B7.5 49.05(n)
    45.68(a)
      177142  NM_068019.3  NP_500420.3 


    ENSEMBL Gene Tree for IQSEC1 (if available)
    TreeFam Gene Tree for IQSEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQSEC1 gene
    CYTH32  IQSEC32  CYTH22  ARFGEF22  ENSG000002684652  ARFGEF12  CYTH42  IQSEC22  
    CYTH12  FBXO82  
    8 SIMAP similar genes for IQSEC1 using alignment to 4 protein entries:     IQEC1_HUMAN (see all proteins):
    PSCD2L    IQSEC2    CYTH2    CYTH1    CYTH3    FLJ00017
    MST051    IQSEC3

    IQSEC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3849 SNPs in IQSEC1 are shown (see all 3849)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0270044
    ----see VAR_0270042 V I mis40--------
    rs748924101,2
    C--12938087(+) AGAACA/GTCTTT 2 -- ds50010--------
    rs1831863281,2
    --12938093(+) TCTTTC/TAATCA 2 -- ds50010--------
    rs111286221,2
    --12938140(+) TGGTCA/CCCAAA 2 -- ds50010--------
    rs1875454521,2
    --12938193(+) AGTTCA/CTTTTA 2 -- ds50010--------
    rs1919684701,2
    --12938257(+) AAAGGA/GGAAAT 2 -- ds50010--------
    rs1437437421,2
    --12938263(+) GAAATC/TGCAGA 2 -- ds50010--------
    rs1147948331,2
    F--12938264(+) AAATCG/ACAGAA 2 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1850030791,2
    --12938678(+) GGCCAA/CCAGGG 2 -- ut310--------
    rs1155322191,2
    C,F--12938762(+) ACAACC/TATGGT 2 -- ut311Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for IQSEC1 (12938719 - 13114617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for IQSEC1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv999756CNV Deletion20482838
    esv2724937CNV Deletion23290073
    nsv460442CNV Loss19166990
    nsv876542CNV Loss21882294
    dgv5108n71CNV Loss21882294
    nsv834617CNV Loss17160897
    nsv470405CNV Loss18288195
    esv33247CNV Loss17666407
    nsv876545CNV Loss21882294
    nsv460435CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610166    OMIM disorders: --

    7 diseases for IQSEC1:    About MalaCards
    intracranial aneurysm    lung adenocarcinoma    adenocarcinoma    pancreatic cancer
    alzheimer's disease    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for IQSEC1:
    Intracranial aneurysm

    IQSEC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IQSEC1
    Human Genome Epidemiology (HuGE) Navigator: IQSEC1 (1 document)

    Export disorders for IQSEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQSEC1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with IQSEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. Genome-wide association study to identify genetic var iants present in Japanese patients harboring intracranial aneurysms. (PubMed id 20613766)1, 4 Akiyama K....Inoue I. (2010)
    3. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. (PubMed id 16461286)1, 2 Dunphy J.L....Casanova J.E. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP- ribosylation factor 6. (PubMed id 11226253)1, 2 Someya A.... Vaughan M. (2001)
    6. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
    7. GEP100 regulates epidermal growth factor-induced MDA-M B-231 breast cancer cell invasion through the activation of Arf6/ERK/uPAR signal ing pathway. (PubMed id 23747719)1 Hu Z....Gu L. (2013)
    8. The pleckstrin homology (PH) domain of the Arf exchang e factor Brag2 is an allosteric binding site. (PubMed id 22613714)1 Jian X....Randazzo P.A. (2012)
    9. BRAG2/GEP100/IQSec1 interacts with clathrin and regula tes a5b1 integrin endocytosis through activation of ADP ribosylation factor 5 (A rf5). (PubMed id 22815487)1 Moravec R....Casanova J.E. (2012)
    10. Down-regulation of GEP100 causes increase in E-cadheri n levels and inhibits pancreatic cancer cell invasion. (PubMed id 22662237)1 Xie C.G....Jia L.T. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9922 HGNC: 29112 AceView: IQSEC1 Ensembl:ENSG00000144711 euGenes: HUgn9922
    ECgene: IQSEC1 Kegg: 9922 H-InvDB: IQSEC1

    (According to HUGE)
    About This Section
    HUGE: KIAA0763

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQSEC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IQSEC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQSEC1 gene:
    Search GeneIP for patents involving IQSEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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