Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IQGAP3 Gene

Aliases for IQGAP3 Gene

  • IQ Motif Containing GTPase Activating Protein 3 2 3 5

External Ids for IQGAP3 Gene

Previous GeneCards Identifiers for IQGAP3 Gene

  • GC01M153273
  • GC01M153713
  • GC01M153711
  • GC01M153308
  • GC01M154761
  • GC01M127855

Summaries for IQGAP3 Gene

GeneCards Summary for IQGAP3 Gene

IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and G-protein signaling RAC1 in cellular process. GO annotations related to this gene include calmodulin binding and Ras GTPase binding. An important paralog of this gene is IQGAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP3 Gene

Genomics for IQGAP3 Gene

Regulatory Elements for IQGAP3 Gene

Enhancers for IQGAP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IQGAP3 on UCSC Golden Path with GeneCards custom track

Promoters for IQGAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IQGAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IQGAP3 Gene

156,525,405 bp from pter
156,572,604 bp from pter
47,200 bases
Minus strand

Genomic View for IQGAP3 Gene

Genes around IQGAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQGAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP3 Gene

Proteins for IQGAP3 Gene

  • Protein details for IQGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating-like protein IQGAP3
    Protein Accession:
    Secondary Accessions:
    • Q5T3H8

    Protein attributes for IQGAP3 Gene

    1631 amino acids
    Molecular mass:
    184699 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQGAP3 Gene

neXtProt entry for IQGAP3 Gene

Proteomics data for IQGAP3 Gene at MOPED

Post-translational modifications for IQGAP3 Gene

  • Ubiquitination at Lys 1067, Lys 1158, and Lys 1245
  • Modification sites at PhosphoSitePlus

Other Protein References for IQGAP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQGAP3 Gene

Domains & Families for IQGAP3 Gene

Suggested Antigen Peptide Sequences for IQGAP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 4 IQ domains.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with IQGAP3: view

No data available for Gene Families for IQGAP3 Gene

Function for IQGAP3 Gene

genes like me logo Genes that share phenotypes with IQGAP3: view

Animal Model Products

miRNA for IQGAP3 Gene

miRTarBase miRNAs that target IQGAP3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQGAP3 Gene

Localization for IQGAP3 Gene

Subcellular locations from

Jensen Localization Image for IQGAP3 Gene COMPARTMENTS Subcellular localization image for IQGAP3 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP3 Gene

Pathways & Interactions for IQGAP3 Gene

genes like me logo Genes that share pathways with IQGAP3: view

Pathways by source for IQGAP3 Gene

1 KEGG pathway for IQGAP3 Gene

Interacting Proteins for IQGAP3 Gene

Gene Ontology (GO) - Biological Process for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0008361 regulation of cell size IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for SIGNOR curated interactions for IQGAP3 Gene

Drugs & Compounds for IQGAP3 Gene

No Compound Related Data Available

Transcripts for IQGAP3 Gene

Unigene Clusters for IQGAP3 Gene

IQ motif containing GTPase activating protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39

Relevant External Links for IQGAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQGAP3 Gene

mRNA expression in normal human tissues for IQGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP3 Gene

This gene is overexpressed in Colon - Transverse (x4.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for IQGAP3 Gene

This gene is overexpressed in Breast (38.0) and Bone (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IQGAP3 Gene

SOURCE GeneReport for Unigene cluster for IQGAP3 Gene Hs.591495

genes like me logo Genes that share expression patterns with IQGAP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IQGAP3 Gene

Orthologs for IQGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IQGAP3 35
  • 89.84 (n)
  • 90.93 (a)
  • 90 (a)
(Canis familiaris)
Mammalia IQGAP3 35
  • 85.78 (n)
  • 85.71 (a)
  • 85 (a)
(Mus musculus)
Mammalia Iqgap3 35
  • 84.9 (n)
  • 85.04 (a)
Iqgap3 16
Iqgap3 36
  • 85 (a)
(Pan troglodytes)
Mammalia IQGAP3 35
  • 98.76 (n)
  • 98.57 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Iqgap3 35
  • 84.98 (n)
  • 85.53 (a)
(Monodelphis domestica)
Mammalia IQGAP3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 44 (a)
-- 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqgap3 35
  • 66.32 (n)
  • 67.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7754 35
(Danio rerio)
Actinopterygii IQGAP3 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea pes-7 35
  • 43.08 (n)
  • 28.94 (a)
pes-7 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 36
  • 19 (a)
IQG1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for IQGAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IQGAP3 Gene

Gene Tree for IQGAP3 (if available)
Gene Tree for IQGAP3 (if available)

Paralogs for IQGAP3 Gene

Paralogs for IQGAP3 Gene

(2) SIMAP similar genes for IQGAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IQGAP3: view

Variants for IQGAP3 Gene

Sequence variations from dbSNP and Humsavar for IQGAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2488269 - 156,556,652(+) CACTC(C/T)CCTCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs11264498 - 156,556,595(+) GTACA(C/G)TGGAG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11264496 - 156,548,641(+) ACAGT(C/T)GGGAA nc-transcript-variant, reference, missense
rs744224 - 156,548,587(+) TGGAC(A/G)CTGTT nc-transcript-variant, reference, missense
rs1078890 - 156,544,469(+) CCAAT(A/G)AGCCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IQGAP3 Gene

Variant ID Type Subtype PubMed ID
esv2675734 CNV Deletion 23128226
nsv3077 CNV Loss 18451855
nsv436331 CNV Deletion 17901297
esv2506598 CNV Deletion 19546169
esv994163 CNV Deletion 20482838
nsv511716 CNV Loss 21212237
esv2384844 CNV Deletion 18987734
esv2824 CNV Deletion 18987735
esv1007783 CNV Deletion 20482838
esv1268515 CNV Deletion 17803354
esv2718440 CNV Deletion 23290073
esv8068 CNV Loss 19470904

Variation tolerance for IQGAP3 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.99; 98.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQGAP3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP3 Gene

Disorders for IQGAP3 Gene

Relevant External Links for IQGAP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IQGAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQGAP3 Gene

Publications for IQGAP3 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48 67
  2. The biology of IQGAP proteins: beyond the cytoskeleton. (PMID: 25722290) Hedman A.C. … Sacks D.B. (EMBO Rep. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for IQGAP3 Gene

Sources for IQGAP3 Gene