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Aliases for IQGAP3 Gene

Aliases for IQGAP3 Gene

  • IQ Motif Containing GTPase Activating Protein 3 2 3 5

External Ids for IQGAP3 Gene

Previous GeneCards Identifiers for IQGAP3 Gene

  • GC01M153273
  • GC01M153713
  • GC01M153711
  • GC01M153308
  • GC01M154761
  • GC01M127855

Summaries for IQGAP3 Gene

GeneCards Summary for IQGAP3 Gene

IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is a Protein Coding gene. Among its related pathways are G-protein signaling RAC1 in cellular process and RHO GTPases activate IQGAPs. Gene Ontology (GO) annotations related to this gene include calmodulin binding and Ras GTPase binding. An important paralog of this gene is IQGAP1.

Additional gene information for IQGAP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP3 Gene

Genomics for IQGAP3 Gene

GeneHancer (GH) Regulatory Elements for IQGAP3 Gene

Promoters and enhancers for IQGAP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156569 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 550.8 +1.1 1060 3.3 ZFP64 ARID4B SIN3A FEZF1 ZNF2 POLR2B E2F8 ZNF143 FOS KLF13 IQGAP3 NAXE GON4L KHDC4 RRNAD1 YY1AP1 MEF2D PRCC BCAN CCT3
GH01I156523 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +47.6 47635 2.4 HDAC1 PKNOX1 SIN3A TCF12 GATA2 RUNX3 EGR2 CEBPB USF2 ZNF592 GC01P156524 NAXE IQGAP3 C1orf61 MIR9-1 GPATCH4 ENSG00000260460 MEF2D RRNAD1
GH01I156419 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 5 +150.7 150677 4.3 ATF1 SIN3A ZNF2 TCF12 ZNF121 GLIS2 FOS ATF7 RUNX3 SP3 MIR9-1 C1orf61 KHDC4 GON4L RRNAD1 ENSG00000271267 MSTO1 MSTO2P CCT3 PRCC
GH01I156526 Enhancer 0.6 ENCODE dbSUPER 11.2 +46.3 46310 0.2 SIN3A EGR2 GC01P156524 IQGAP3 NAXE
GH01I156527 Enhancer 0.4 dbSUPER 11.2 +44.6 44601 1.5 ZBTB6 ZNF600 IQGAP3 NAXE GC01P156524
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQGAP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQGAP3 gene promoter:

Genomic Locations for IQGAP3 Gene

Genomic Locations for IQGAP3 Gene
47,200 bases
Minus strand

Genomic View for IQGAP3 Gene

Genes around IQGAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQGAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP3 Gene

Proteins for IQGAP3 Gene

  • Protein details for IQGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating-like protein IQGAP3
    Protein Accession:
    Secondary Accessions:
    • Q5T3H8

    Protein attributes for IQGAP3 Gene

    1631 amino acids
    Molecular mass:
    184699 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQGAP3 Gene

neXtProt entry for IQGAP3 Gene

Post-translational modifications for IQGAP3 Gene

  • Ubiquitination at isoforms=1067, isoforms=1158, and isoforms=1245

Other Protein References for IQGAP3 Gene

Antibody Products

  • Abcam antibodies for IQGAP3
  • Santa Cruz Biotechnology (SCBT) Antibodies for IQGAP3

No data available for DME Specific Peptides for IQGAP3 Gene

Domains & Families for IQGAP3 Gene

Gene Families for IQGAP3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IQGAP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQGAP3: view

No data available for UniProtKB/Swiss-Prot for IQGAP3 Gene

Function for IQGAP3 Gene

Gene Ontology (GO) - Molecular Function for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IPI 21299499
GO:0017016 Ras GTPase binding IEA --
GO:0017048 Rho GTPase binding IEA --
GO:0070856 myosin VI light chain binding IPI 21299499
genes like me logo Genes that share ontologies with IQGAP3: view
genes like me logo Genes that share phenotypes with IQGAP3: view

miRNA for IQGAP3 Gene

miRTarBase miRNAs that target IQGAP3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQGAP3 Gene

Localization for IQGAP3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQGAP3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP3 Gene

Pathways & Interactions for IQGAP3 Gene

genes like me logo Genes that share pathways with IQGAP3: view

Pathways by source for IQGAP3 Gene

1 KEGG pathway for IQGAP3 Gene

Gene Ontology (GO) - Biological Process for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for SIGNOR curated interactions for IQGAP3 Gene

Drugs & Compounds for IQGAP3 Gene

No Compound Related Data Available

Transcripts for IQGAP3 Gene

Unigene Clusters for IQGAP3 Gene

IQ motif containing GTPase activating protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39

Relevant External Links for IQGAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQGAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP3 Gene

This gene is overexpressed in Colon - Transverse (x4.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for IQGAP3 Gene

This gene is overexpressed in Breast (38.0) and Bone (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IQGAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of IQGAP3 Gene:


SOURCE GeneReport for Unigene cluster for IQGAP3 Gene:


Evidence on tissue expression from TISSUES for IQGAP3 Gene

  • Liver(3)
  • Lung(2.5)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with IQGAP3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQGAP3 Gene

Orthologs for IQGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQGAP3 33 34
  • 98.76 (n)
(Bos Taurus)
Mammalia IQGAP3 33 34
  • 89.84 (n)
(Canis familiaris)
Mammalia IQGAP3 33 34
  • 85.78 (n)
(Rattus norvegicus)
Mammalia Iqgap3 33
  • 84.98 (n)
(Mus musculus)
Mammalia Iqgap3 33 16 34
  • 84.9 (n)
(Monodelphis domestica)
Mammalia IQGAP3 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
-- 34
  • 56 (a)
-- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqgap3 33
  • 66.32 (n)
(Danio rerio)
Actinopterygii IQGAP3 34
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7754 33
(Caenorhabditis elegans)
Secernentea pes-7 33 34
  • 43.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 34 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for IQGAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IQGAP3 Gene

Gene Tree for IQGAP3 (if available)
Gene Tree for IQGAP3 (if available)

Paralogs for IQGAP3 Gene

Paralogs for IQGAP3 Gene

(2) SIMAP similar genes for IQGAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IQGAP3: view

Variants for IQGAP3 Gene

Sequence variations from dbSNP and Humsavar for IQGAP3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024878 -- 156,538,926(-) A/G coding_sequence_variant, missense_variant
rs1000222596 -- 156,560,234(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000224720 -- 156,560,556(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000255627 -- 156,560,233(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000294317 -- 156,526,870(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQGAP3 Gene

Variant ID Type Subtype PubMed ID
dgv205n106 CNV deletion 24896259
esv1007783 CNV deletion 20482838
esv1268515 CNV deletion 17803354
esv2384844 CNV deletion 18987734
esv2506598 CNV deletion 19546169
esv2675734 CNV deletion 23128226
esv2718440 CNV deletion 23290073
esv2824 CNV loss 18987735
esv2849569 CNV deletion 24192839
esv3541123 CNV deletion 23714750
esv3587638 CNV loss 21293372
esv8068 CNV loss 19470904
esv994163 CNV deletion 20482838
nsv1078255 CNV deletion 25765185
nsv1119404 CNV insertion 24896259
nsv3077 CNV deletion 18451855
nsv436331 CNV deletion 17901297
nsv511716 CNV loss 21212237
nsv952215 CNV deletion 24416366
nsv957909 CNV deletion 24416366

Variation tolerance for IQGAP3 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.99; 98.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQGAP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP3 Gene

Disorders for IQGAP3 Gene

Additional Disease Information for IQGAP3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IQGAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQGAP3 Gene

Publications for IQGAP3 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers. (PMID: 29073199) Kumar D … Dixit M (PloS one 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for IQGAP3 Gene

Sources for IQGAP3 Gene

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