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Aliases for IQGAP3 Gene

Aliases for IQGAP3 Gene

  • IQ Motif Containing GTPase Activating Protein 3 2 3 5

External Ids for IQGAP3 Gene

Previous GeneCards Identifiers for IQGAP3 Gene

  • GC01M153273
  • GC01M153713
  • GC01M153711
  • GC01M153308
  • GC01M154761
  • GC01M127855

Summaries for IQGAP3 Gene

GeneCards Summary for IQGAP3 Gene

IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with IQGAP3 include Nut Allergy. Among its related pathways are RHO GTPases activate IQGAPs and Signaling by GPCR. GO annotations related to this gene include calmodulin binding and Ras GTPase binding. An important paralog of this gene is IQGAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP3 Gene

Genomics for IQGAP3 Gene

Regulatory Elements for IQGAP3 Gene

Enhancers for IQGAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156523 1.4 FANTOM5 Ensembl ENCODE 11.2 +47.6 47604 2.8 HDAC1 PKNOX1 CBX3 RAD21 YY1 ZNF121 EGR2 USF2 CEBPB NR2F2 NAXE IQGAP3 C1orf61 MIR9-1 GPATCH4 ENSG00000260460 MEF2D RRNAD1 GC01P156524
GH01F156421 1 ENCODE 5 +150.3 150326 3.6 ATF1 ZNF2 ZNF121 GLIS2 FOS ZNF263 SP3 NFYC REST ZNF623 KIAA0907 RRNAD1 MSTO2P IQGAP3 PAQR6 MIR9-1 GC01M156428
GH01F156569 1.4 FANTOM5 ENCODE 0.8 +1.1 1061 3.3 ATF1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 GLI4 ZNF2 ETS1 ZNF143 NAXE PEAR1 MEF2D MSTO2P BCAN CCT3 TSACC GPATCH4 TTC24 IQGAP3
GH01F156551 1.1 Ensembl ENCODE 0.3 +19.9 19852 3.3 TBP HDAC1 CBX3 RAD21 RFX5 RCOR1 FOS SMARCC1 ZBTB11 CEBPB NAXE MEF2D HAPLN2 BCAN CCT3 C1orf61 MIR9-1 TSACC SMG5 IQGAP3
GH01F156559 0.5 ENCODE 0.4 +12.7 12691 0.3 ARID1B GATA3 SCRT2 IKZF1 NAXE HAPLN2 C1orf61 MIR9-1 ISG20L2 RRNAD1 IQGAP3 GC01P156524
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQGAP3 on UCSC Golden Path with GeneCards custom track

Promoters for IQGAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000671218 504 1800 ATF1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 GLI4 ZNF2 ETS1 ZNF143

Genomic Location for IQGAP3 Gene

Chromosome:
1
Start:
156,525,405 bp from pter
End:
156,572,604 bp from pter
Size:
47,200 bases
Orientation:
Minus strand

Genomic View for IQGAP3 Gene

Genes around IQGAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQGAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP3 Gene

Proteins for IQGAP3 Gene

  • Protein details for IQGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI3-IQGA3_HUMAN
    Recommended name:
    Ras GTPase-activating-like protein IQGAP3
    Protein Accession:
    Q86VI3
    Secondary Accessions:
    • Q5T3H8

    Protein attributes for IQGAP3 Gene

    Size:
    1631 amino acids
    Molecular mass:
    184699 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQGAP3 Gene

neXtProt entry for IQGAP3 Gene

Post-translational modifications for IQGAP3 Gene

  • Ubiquitination at Lys 1067, Lys 1158, and Lys 1245
  • Modification sites at PhosphoSitePlus

Other Protein References for IQGAP3 Gene

No data available for DME Specific Peptides for IQGAP3 Gene

Domains & Families for IQGAP3 Gene

Suggested Antigen Peptide Sequences for IQGAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VI3

UniProtKB/Swiss-Prot:

IQGA3_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 4 IQ domains.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with IQGAP3: view

No data available for Gene Families for IQGAP3 Gene

Function for IQGAP3 Gene

Gene Ontology (GO) - Molecular Function for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IPI 21299499
GO:0017016 Ras GTPase binding IEA --
GO:0017048 Rho GTPase binding IEA --
GO:0070856 myosin VI light chain binding IPI 21299499
genes like me logo Genes that share ontologies with IQGAP3: view
genes like me logo Genes that share phenotypes with IQGAP3: view

Animal Model Products

miRNA for IQGAP3 Gene

miRTarBase miRNAs that target IQGAP3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQGAP3 Gene

Localization for IQGAP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQGAP3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP3 Gene

Pathways & Interactions for IQGAP3 Gene

genes like me logo Genes that share pathways with IQGAP3: view

Pathways by source for IQGAP3 Gene

1 KEGG pathway for IQGAP3 Gene

Gene Ontology (GO) - Biological Process for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007265 Ras protein signal transduction IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for SIGNOR curated interactions for IQGAP3 Gene

Transcripts for IQGAP3 Gene

Unigene Clusters for IQGAP3 Gene

IQ motif containing GTPase activating protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39
SP1:
SP2:
SP3:

Relevant External Links for IQGAP3 Gene

GeneLoc Exon Structure for
IQGAP3
ECgene alternative splicing isoforms for
IQGAP3

Expression for IQGAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP3 Gene

This gene is overexpressed in Colon - Transverse (x4.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for IQGAP3 Gene

This gene is overexpressed in Breast (38.0) and Bone (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IQGAP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of IQGAP3 Gene:

IQGAP3

SOURCE GeneReport for Unigene cluster for IQGAP3 Gene:

Hs.591495
genes like me logo Genes that share expression patterns with IQGAP3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IQGAP3 Gene

Orthologs for IQGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQGAP3 34 35
  • 98.76 (n)
cow
(Bos Taurus)
Mammalia IQGAP3 34 35
  • 89.84 (n)
dog
(Canis familiaris)
Mammalia IQGAP3 34 35
  • 85.78 (n)
rat
(Rattus norvegicus)
Mammalia Iqgap3 34
  • 84.98 (n)
mouse
(Mus musculus)
Mammalia Iqgap3 34 16 35
  • 84.9 (n)
oppossum
(Monodelphis domestica)
Mammalia IQGAP3 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia iqgap3 34
  • 66.32 (n)
zebrafish
(Danio rerio)
Actinopterygii IQGAP3 35
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7754 34
worm
(Caenorhabditis elegans)
Secernentea pes-7 34 35
  • 43.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 35 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for IQGAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IQGAP3 Gene

ENSEMBL:
Gene Tree for IQGAP3 (if available)
TreeFam:
Gene Tree for IQGAP3 (if available)

Paralogs for IQGAP3 Gene

Paralogs for IQGAP3 Gene

(2) SIMAP similar genes for IQGAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IQGAP3: view

Variants for IQGAP3 Gene

Sequence variations from dbSNP and Humsavar for IQGAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1055630 -- 156,525,728(-) ttttG(A/G)GCTCA utr-variant-3-prime
rs10611202 -- 156,525,754(+) AAAAA(-/A)TGAAA utr-variant-3-prime
rs10684312 -- 156,574,179(+) CCTAG(-/GT)GTGTA upstream-variant-2KB
rs1078890 -- 156,544,469(+) CCAAT(A/G)AGCCT reference, missense
rs111301245 -- 156,530,947(+) AGAGG(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQGAP3 Gene

Variant ID Type Subtype PubMed ID
dgv205n106 CNV deletion 24896259
esv1007783 CNV deletion 20482838
esv1268515 CNV deletion 17803354
esv2384844 CNV deletion 18987734
esv2506598 CNV deletion 19546169
esv2675734 CNV deletion 23128226
esv2718440 CNV deletion 23290073
esv2824 CNV loss 18987735
esv2849569 CNV deletion 24192839
esv3541123 CNV deletion 23714750
esv3587638 CNV loss 21293372
esv8068 CNV loss 19470904
esv994163 CNV deletion 20482838
nsv1078255 CNV deletion 25765185
nsv1119404 CNV insertion 24896259
nsv3077 CNV deletion 18451855
nsv436331 CNV deletion 17901297
nsv511716 CNV loss 21212237
nsv952215 CNV deletion 24416366
nsv957909 CNV deletion 24416366

Variation tolerance for IQGAP3 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.99; 98.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQGAP3 Gene

Human Gene Mutation Database (HGMD)
IQGAP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQGAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP3 Gene

Disorders for IQGAP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQGAP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nut allergy
  • allergy to nuts
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IQGAP3

Genetic Association Database (GAD)
IQGAP3
Human Genome Epidemiology (HuGE) Navigator
IQGAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQGAP3
genes like me logo Genes that share disorders with IQGAP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQGAP3 Gene

Publications for IQGAP3 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The biology of IQGAP proteins: beyond the cytoskeleton. (PMID: 25722290) Hedman A.C. … Sacks D.B. (EMBO Rep. 2015) 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for IQGAP3 Gene

Sources for IQGAP3 Gene

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