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Aliases for IQGAP3 Gene

Aliases for IQGAP3 Gene

  • IQ Motif Containing GTPase Activating Protein 3 2 3

External Ids for IQGAP3 Gene

Previous GeneCards Identifiers for IQGAP3 Gene

  • GC01M153273
  • GC01M153713
  • GC01M153711
  • GC01M153308
  • GC01M154761
  • GC01M127855

Summaries for IQGAP3 Gene

GeneCards Summary for IQGAP3 Gene

IQGAP3 (IQ Motif Containing GTPase Activating Protein 3) is a Protein Coding gene. Diseases associated with IQGAP3 include peanut allergic reaction. Among its related pathways are Signaling by GPCR and Regulation of actin cytoskeleton. GO annotations related to this gene include calmodulin binding and Ras GTPase binding. An important paralog of this gene is IQGAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP3 Gene

Genomics for IQGAP3 Gene

Regulatory Elements for IQGAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IQGAP3 Gene

Chromosome:
1
Start:
156,525,405 bp from pter
End:
156,572,604 bp from pter
Size:
47,200 bases
Orientation:
Minus strand

Genomic View for IQGAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IQGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP3 Gene

Proteins for IQGAP3 Gene

  • Protein details for IQGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI3-IQGA3_HUMAN
    Recommended name:
    Ras GTPase-activating-like protein IQGAP3
    Protein Accession:
    Q86VI3
    Secondary Accessions:
    • Q5T3H8

    Protein attributes for IQGAP3 Gene

    Size:
    1631 amino acids
    Molecular mass:
    184699 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQGAP3 Gene

neXtProt entry for IQGAP3 Gene

Proteomics data for IQGAP3 Gene at MOPED

Post-translational modifications for IQGAP3 Gene

  • Ubiquitination at Lys 1067, Lys 1158, and Lys 1245
  • Modification sites at PhosphoSitePlus

Other Protein References for IQGAP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IQGAP3 Gene

Domains & Families for IQGAP3 Gene

Suggested Antigen Peptide Sequences for IQGAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VI3

UniProtKB/Swiss-Prot:

IQGA3_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 4 IQ domains.
  • Contains 1 Ras-GAP domain.
genes like me logo Genes that share domains with IQGAP3: view

No data available for Gene Families for IQGAP3 Gene

Function for IQGAP3 Gene

Gene Ontology (GO) - Molecular Function for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IPI 21299499
GO:0017016 Ras GTPase binding --
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

Phenotypes for IQGAP3 Gene

genes like me logo Genes that share phenotypes with IQGAP3: view

Animal Model Products

miRNA for IQGAP3 Gene

miRTarBase miRNAs that target IQGAP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQGAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IQGAP3 Gene

Localization for IQGAP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IQGAP3 Gene COMPARTMENTS Subcellular localization image for IQGAP3 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQGAP3 Gene

Pathways & Interactions for IQGAP3 Gene

genes like me logo Genes that share pathways with IQGAP3: view

Pathways by source for IQGAP3 Gene

1 KEGG pathway for IQGAP3 Gene

Interacting Proteins for IQGAP3 Gene

Gene Ontology (GO) - Biological Process for IQGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000187 activation of MAPK activity IEA --
GO:0001934 positive regulation of protein phosphorylation --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with IQGAP3: view

No data available for SIGNOR curated interactions for IQGAP3 Gene

Drugs & Compounds for IQGAP3 Gene

No Compound Related Data Available

Transcripts for IQGAP3 Gene

Unigene Clusters for IQGAP3 Gene

IQ motif containing GTPase activating protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQGAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39
SP1:
SP2:
SP3:

Relevant External Links for IQGAP3 Gene

GeneLoc Exon Structure for
IQGAP3
ECgene alternative splicing isoforms for
IQGAP3

Expression for IQGAP3 Gene

mRNA expression in normal human tissues for IQGAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP3 Gene

This gene is overexpressed in Colon - Transverse (x4.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for IQGAP3 Gene

This gene is overexpressed in Breast (38.0) and Bone (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IQGAP3 Gene



SOURCE GeneReport for Unigene cluster for IQGAP3 Gene Hs.591495

genes like me logo Genes that share expression patterns with IQGAP3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IQGAP3 Gene

Orthologs for IQGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IQGAP3 35
  • 89.84 (n)
  • 90.93 (a)
IQGAP3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IQGAP3 35
  • 85.78 (n)
  • 85.71 (a)
IQGAP3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iqgap3 35
  • 84.9 (n)
  • 85.04 (a)
Iqgap3 16
Iqgap3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IQGAP3 35
  • 98.76 (n)
  • 98.57 (a)
IQGAP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iqgap3 35
  • 84.98 (n)
  • 85.53 (a)
oppossum
(Monodelphis domestica)
Mammalia IQGAP3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia iqgap3 35
  • 66.32 (n)
  • 67.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7754 35
zebrafish
(Danio rerio)
Actinopterygii IQGAP3 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pes-7 35
  • 43.08 (n)
  • 28.94 (a)
pes-7 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 36
  • 19 (a)
OneToMany
IQG1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for IQGAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IQGAP3 Gene

ENSEMBL:
Gene Tree for IQGAP3 (if available)
TreeFam:
Gene Tree for IQGAP3 (if available)

Paralogs for IQGAP3 Gene

Paralogs for IQGAP3 Gene

(2) SIMAP similar genes for IQGAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IQGAP3: view

Variants for IQGAP3 Gene

Sequence variations from dbSNP and Humsavar for IQGAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14871 -- 156,525,476(-) TCTCT(A/G)TTGTC utr-variant-3-prime, nc-transcript-variant
rs728917 -- 156,534,884(+) TGCTT(A/T)AGGCC intron-variant
rs732361 -- 156,530,366(+) TTCTG(C/T)TCCCA intron-variant
rs732362 -- 156,530,566(+) ACAGG(A/C/G)GAAGA intron-variant
rs745596 -- 156,534,787(+) TGGTG(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQGAP3 Gene

Variant ID Type Subtype PubMed ID
esv2675734 CNV Deletion 23128226
nsv3077 CNV Loss 18451855
nsv436331 CNV Deletion 17901297
esv2506598 CNV Deletion 19546169
esv994163 CNV Deletion 20482838
nsv511716 CNV Loss 21212237
esv2384844 CNV Deletion 18987734
esv2824 CNV Deletion 18987735
esv1007783 CNV Deletion 20482838
esv1268515 CNV Deletion 17803354
esv2718440 CNV Deletion 23290073
esv8068 CNV Loss 19470904

Variation tolerance for IQGAP3 Gene

Residual Variation Intolerance Score: 43.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.99; 98.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQGAP3 Gene

HapMap Linkage Disequilibrium report
IQGAP3
Human Gene Mutation Database (HGMD)
IQGAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP3 Gene

Disorders for IQGAP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQGAP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
peanut allergic reaction
  • peanut allergy
- elite association

Relevant External Links for IQGAP3

Genetic Association Database (GAD)
IQGAP3
Human Genome Epidemiology (HuGE) Navigator
IQGAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQGAP3
genes like me logo Genes that share disorders with IQGAP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQGAP3 Gene

Publications for IQGAP3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67

Products for IQGAP3 Gene

Sources for IQGAP3 Gene

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