IQGAP3 Gene
protein-coding GIFtS: 51
GCID: GC01M156496
|
|
IQ motif containing GTPase activating protein 3
| |
Aliases
for IQGAP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IQ Motif Containing GTPase Activating Protein 31 2 | | Ras GTPase-Activating-Like Protein IQGAP32 |
Export aliases for IQGAP3 gene to outside databasesPrevious GC identifers: GC01M153273 GC01M153713 GC01M153711 GC01M153308 GC01M154761 GC01M127855 |
Summaries
for IQGAP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IQGAP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IQGAP3 gene promoter:
STAT5B STAT1 NF-1 RFX1 AML1a STAT1beta YY1 STAT1alpha Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for IQGAP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQGAP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21.3IQGAP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M156496: view genomic region
(about GC identifiers)
Start:
|
156,495,197 bp from pter |
End:
|
156,542,396 bp from pter |
Size:
|
47,200 bases |
Orientation:
|
minus strand |
|
Proteins
for IQGAP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IQGA3_HUMAN, Q86VI3 (See
protein sequence)Recommended Name: Ras GTPase-activating-like protein IQGAP3 Size: 1631 amino acids; 184699 Da
1 PDB 3D structure from  and Proteopedia  for IQGAP3:3ISU (3D)
Secondary accessions: Q5T3H8Explore the universe of human proteins at neXtProt for IQGAP3: NX_Q86VI3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VI3
IQGAP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_839943.2
ENSEMBL proteins: ENSP00000354451 ENSP00000436603
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IQGAP3 for ontologies About GeneDecksing
IQGAP3 Antibody Products:
Assay Products for IQGAP3: |
Protein
Domains /
Families
for IQGAP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IQGAP3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q86VI3ProtoNet protein and cluster: Q86VI3 4 Blocks protein families: IPB000593 RasGAP protein IPB001715 Calponin-like actin-binding IPB001936 Ras GTPase-activating protein IPB011575 RasGAP
UniProtKB/Swiss-Prot: IQGA3_HUMAN, Q86VI3Similarity: Contains 1 CH (calponin-homology) domainSimilarity: Contains 4 IQ domainsSimilarity: Contains 1 Ras-GAP domain |
Function
for IQGAP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IQGAP3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IQGAP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP3 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
IQGAP3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IQGAP3:
Animal Models:
1 MGI phenotypic allele  for Iqgap3 (no phenotypes)
IQGAP3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IQGAP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_RAC1 in cellular process | | | 2 | Regulation of Actin Cytoskeleton | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for IQGAP3
1 
Kegg Pathway (Kegg details for IQGAP3):
IQGAP3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQGAP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for IQGAP3 (Q86VI33 ENSP000003544514) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
IEA | -- | | GO:0000187 | activation of MAPK activity |
IEA | -- | | GO:0001934 | positive regulation of protein phosphorylation |
-- | -- | | GO:0007265 | Ras protein signal transduction |
IEA | -- | | GO:0008361 | regulation of cell size |
IEA | -- |
IQGAP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for IQGAP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IQGAP3
Search CenterWatch for drugs/clinical trials and news about IQGAP3 / IQGA3
|
Transcripts
for IQGAP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IQGAP3 gene: NM_178229.4 Unigene Cluster for IQGAP3: IQ motif containing GTPase activating protein 3 Hs.591495 [show with all ESTs]Unigene Representative Sequence: NM_1782294 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361170(uc001fpf.3) ENST00000491900(uc009wsb.1) ENST00000476565
ENST00000498755
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IQGAP3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IQGAP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IQGAP3 (NM_178229) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQGAP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQGAP3 |
Additional cDNA sequence: AB105103.1 AK122653.1 AY253300.1 BC033549.1 BC131536.1 5 DOTS entries: DT.87000688 DT.454418 DT.100782827 DT.432865 DT.92419707 24/114 AceView cDNA sequences (see all 114): AL040371 AW513914 AW850462 BM818787 BM769123 BX117257 NM_178229 BF871797 BM742511 BG169012 BM770887 BX368982 BG675886 BC033549 BM766834 AA830564 AI690773 BF901967 BE145417 CA444484 BM767283 BM910515 BU632393 BM825647
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IQGAP3
|
Expression
for IQGAP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IQGAP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IQGAP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IQGAP3
SOURCE GeneReport for Unigene cluster: Hs.591495
SABiosciences Custom PCR Arrays for IQGAP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IQGAP3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP3 |
Orthologs
for IQGAP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IQGAP3 gene from 3/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01087386.16 |
-- |
57(a) |
1 ↔ 1 |
16(58627752-58671282) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
38(a) |
1 → many |
GroupUn.5(65937-74573) |
worm
(Caenorhabditis elegans) |
Secernentea |
pes-76 |
Patterned Expression Site family member (pes-7) |
25(a) |
possible ortholog |
I(14263289-14271305) |
ENSEMBL Gene Tree for IQGAP3 (if available)
TreeFam Gene Tree for IQGAP3 (if available) |
Paralogs
for IQGAP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IQGAP3 gene
- IQGAP22 IQGAP12
2 SIMAP similar genes for IQGAP3 using alignment to 3 protein entries: IQGA3_HUMAN (see all proteins):IQGAP1 IQGAP2
IQGAP3 for paralogs About GeneDecksing
|
Genomic Variants
for IQGAP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IQGAP3 (156495197 - 156542396 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for IQGAP3
7 CNVs: 43742 23341 22504 43436 97517 39016 60891
Human Gene Mutation Database (HGMD): IQGAP3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IQGAP3 |
|
Disorders
/ Diseases
for IQGAP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 IQGAP3 for disorders About MalaCards
IQGAP3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: IQGAP3 (1 document)
Export disorders for IQGAP3 gene to outside databases
|
Publications
for IQGAP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IQGAP3 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with IQGAP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for IQGAP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IQGAP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IQGAP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IQGAP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IQGAP3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IQGAP3 gene:
Search GeneIP for patents involving IQGAP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IQGAP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IQGAP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IQGAP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQGAP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IQGAP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IQGAP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IQGAP3 |
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| |  |  |  |  | | | | |
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 | | | IQGAP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQGAP3 |
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