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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IQGAP2 Gene

protein-coding GIFtS: 59
GCID: GC05P075699

IQ motif containing GTPase activating protein 2

Explore 2 diseases affiliated with
IQGAP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
IQ Motif Containing GTPase Activating Protein 2¹ ²
Ras GTPase-Activating-Like Protein IQGAP2²

External Ids:	HGNC: 6111¹	Entrez Gene: 10788²	Ensembl: ENSG00000145703⁷	OMIM: 605401⁵	UniProtKB: Q13576³

Export aliases for IQGAP2 gene to outside databases

Previous GC identifers: GC05P074504 GC05P075933 GC05P075737 GC05P075783 GC05P075734 GC05P070906

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IQGAP2:

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain,

one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules,

and with several signaling molecules to regulate cell morphology and motility. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576

Function: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with

calmodulin

Gene Wiki entry for IQGAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IQGAP2 gene promoter:
AML1a Lmo2 MIF-1 Nkx2-5 LCR-F1 HNF-1A POU2F1 POU2F1a HNF-1 Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IQGAP2 promoter sequence

Search SABiosciences Chromatin IP Primers for IQGAP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQGAP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q

IQGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQGAP2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P075699: view genomic region (about GC identifiers)

Start:	75,699,074 bp from pter	End:	76,003,957 bp from pter
Size:	304,884 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576 (See protein sequence)

Recommended Name: Ras GTPase-activating-like protein IQGAP2

Size: 1575 amino acids; 180578 Da

2 PDB 3D structures from and Proteopedia for IQGAP2:

3IEZ (3D)

4EZA (3D)

Secondary accessions: A8K4V1 B7Z8A4

Alternative splicing: 2 isoforms: Q13576-1 Q13576-2

Explore the universe of human proteins at neXtProt for IQGAP2: NX_Q13576

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13576

IQGAP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006624.2

ENSEMBL proteins:

ENSP00000274364 ENSP00000423672 ENSP00000421097 ENSP00000422661 ENSP00000379535

ENSP00000425351 ENSP00000426027 ENSP00000423258 ENSP00000421319 ENSP00000425941

ENSP00000442313

Human Recombinant Protein Products:

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	Novus Biologicals IQGAP2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IQGAP2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005874	microtubule	IDA	--
GO:0005902	microvillus	IEA	--
GO:0015629	actin cytoskeleton	TAS	8756646

IQGAP2 for ontologies About GeneDecksing

IQGAP2 Antibody Products:

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Assay Products for IQGAP2:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IQGAP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IQGAP2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR023152 RasGAP_CS

IPR001936 RasGAP

IPR001715 CH-domain

IPR008936 Rho_GTPase_activation_prot

IPR000048 IQ_motif_EF-hand-BS

Graphical View of Domain Structure for InterPro Entry Q13576

ProtoNet protein and cluster: Q13576

5 Blocks protein families:

IPB000048 IQ calmodulin-binding region

IPB000593 RasGAP protein

IPB001715 Calponin-like actin-binding

IPB001936 Ras GTPase-activating protein

IPB011575 RasGAP

UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576

Similarity: Contains 1 CH (calponin-homology) domain

Similarity: Contains 3 IQ domains

Similarity: Contains 1 Ras-GAP domain

Similarity: Contains 1 WW domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576

Function: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with

calmodulin

Genatlas biochemistry entry for IQGAP2:

IQ motif containing GTPase activating protein 2,S pombe RasGAP-like protein SAR1 homolog,expressed in liver,potential

effector for CDC42,may be involved in cell morphology

miRNA Products:		OriGene 3'-UTR Clone: IQGAP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IQGAP2
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate IQGAP2 (see all 18):
		hsa-miR-34b* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-25 hsa-miR-124 hsa-miR-548x hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: IQGAP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IQGAP2

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		GenScript: all cDNA clones in your preferred vector: IQGAP2 (NM_006633)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IQGAP2
		Search LifeMap BioReagents cell lines for IQGAP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	TAS	8756646
GO:0005095	GTPase inhibitor activity	TAS	8756646
GO:0005096	GTPase activator activity	--	--
GO:0005099	Ras GTPase activator activity	IEA	--
GO:0005516	calmodulin binding	IEA	--

IQGAP2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Iqgap2^tm1Vs for IQGAP2
     5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Iqgap2):

cellular

homeostasis/metabolism

liver/biliary system

mortality/aging

tumorigenesis

IQGAP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

G13 Signaling Pathway

G13 Signaling Pathway

1.00

Apoptotic Pathways in Synovial Fibroblasts

Rac1 Pathway

0.58

Regulation of Actin Cytoskeleton

Regulation of actin cytoskeleton

0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IQGAP2

	Rac1 Pathway
	CDC42 Pathway

1 Cell Signaling Technology (CST) Pathway for IQGAP2

Cytoskeletal Signaling

2 BioSystems Pathways for IQGAP2

	G13 Signaling Pathway
	TNF-alpha/NF-kB Signaling Pathway

1 Kegg Pathway (Kegg details for IQGAP2):

Regulation of actin cytoskeleton

IQGAP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IQGAP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/46 Interacting proteins for IQGAP2 (Q13576^{2, 3} ENSP00000274364⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K3	Q99759²^,³	MINT-48524 I2D: score=2
NFKBIB	Q15653²^,³	MINT-47856 I2D: score=2
CALM1	P62158³, ENSP00000349467⁴	I2D: score=4 STRING: ENSP00000349467
RELA	Q04206²^,³, ENSP00000384273⁴	MINT-48970 MINT-48010 I2D: score=1 STRING: ENSP00000384273
CALM2	P62158³	I2D: score=4

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8756646
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0051056	regulation of small GTPase mediated signal transduction	--	--

IQGAP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IQGAP2
Search CenterWatch for drugs/clinical trials and news about IQGAP2 / IQGA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IQGAP2 gene:

NM_006633.2

Unigene Cluster for IQGAP2:

IQ motif containing GTPase activating protein 2

Hs.291030 [show with all ESTs]

Unigene Representative Sequence: NM_006633

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000274364(uc003kek.3) ENST00000514350 ENST00000505766(uc010izv.2)

ENST00000504815 ENST00000514001 ENST00000396234(uc010izw.1) ENST00000509074

ENST00000502745 ENST00000504254 ENST00000513534 ENST00000515505 ENST00000514579

ENST00000512383 ENST00000504558 ENST00000504477 ENST00000509741 ENST00000512256

ENST00000508410

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IQGAP2
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate IQGAP2 (see all 18):
		hsa-miR-34b* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-25 hsa-miR-124 hsa-miR-548x hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: IQGAP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB208856.1 AK291066.1 AK302510.1 AK302599.1 AK302981.1 AK303054.1 AK307555.1 AK307626.1

AK311619.1 AY351902.1 U51903.1

13 DOTS entries:

DT.214996 DT.92431615 DT.92431622 DT.100673166 DT.307602 DT.100646205 DT.120839123 DT.40116757

DT.70101190 DT.75162310 DT.92431623 DT.95272389 DT.40230547

24/175 AceView cDNA sequences (see all 175):

BP369201 AI758590 AW166166 BM701302 CN479151 BX487777 BU952649 R82241

AV654864 BQ002800 BG776812 AL039349 CR601162 AI056799 AI480341 AI198939

BX110936 AW629087 BM837658 AI742058 BP341853 R82192 BX092943 BG254526

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP2 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23	^
SP1:													-																																-		-
SP2:																							-																						-		-
SP3:																																													-
SP4:
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33a	·	33b	·	33c
SP1:															-
SP2:															-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for IQGAP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IQGAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAGACTCT

About this image

IQGAP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Mesonephros

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See IQGAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IQGAP2

SOURCE GeneReport for Unigene cluster: Hs.291030

UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576

Tissue specificity: Isoform 2 expression is enhanced in testis

SABiosciences Expression via Pathway-Focused PCR Array including IQGAP2:

Cytoskeleton Regulators in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IQGAP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for IQGAP2 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Iqgap2^{1 , 5}	IQ motif containing GTPase activating protein 2^{1, 5}	85.31(n)¹ 89.02(a)¹		13 (50.26 cM)⁵ 544963¹ NM_027711.1¹ NP_081987.1¹ 95627177⁵
chicken (Gallus gallus)	Aves	IQGAP2⁶	Uncharacterized protein	68(a)	1 ↔ 1	Z(22920786-23023263)
lizard (Anolis carolinensis)	Reptilia	IQGAP2⁶	--	69(a)	1 ↔ 1	2(14223216-14292454)
African clawed frog (Xenopus laevis)	Amphibia	AB093561.1²	--	75.01(n)		AB093561.1
zebrafish (Danio rerio)	Actinopterygii	iqgap2⁶	IQ motif containing GTPase activating protein 2	61(a)	1 ↔ 1	5(47688954-47803936)
honey bee (Apis mellifera)	Insecta	--	--	38(a)	1 → many	GroupUn.5(65937-74573)
worm (Caenorhabditis elegans)	Secernentea	pes-7⁶	Patterned Expression Site family member (pes-7)	24(a)	possible ortholog	I(14263289-14271305)

ENSEMBL Gene Tree for IQGAP2 (if available)
TreeFam Gene Tree for IQGAP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IQGAP2 gene

IQGAP3² IQGAP1²

2 SIMAP similar genes for IQGAP2 using alignment to 10 protein entries: IQGA2_HUMAN (see all proteins):

IQGAP1 IQGAP3

IQGAP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190325896^1,2	C,	other	75996952(+)	`GGGGCG/AAAGAG`	2	/A	syn¹		1		EU	1323
rs112714456^1,2	C	--	71134392(+)	`CTCCCC/TTTCAT`	1	--	int¹		0	--	--	--	--
rs190518430^1,2		--	75697207(+)	`GTTCAC/GAGTGA`	1	--	us2k¹		0	--	--	--	--
rs181758580^1,2		--	75697266(+)	`TAAGTC/TATACA`	1	--	us2k¹		0	--	--	--	--
rs187653088^1,2		--	75697289(+)	`TTGTTA/GTGTGT`	1	--	us2k¹		0	--	--	--	--
rs190780292^1,2		--	75697318(+)	`ACTTGA/GCAAAT`	1	--	us2k¹		0	--	--	--	--
rs139265725^1,2		--	75697374(+)	`ATCTCC/TTGACA`	1	--	us2k¹		0	--	--	--	--
rs62363209^1,2	C,F,	--	75697439(+)	`TGCCGA/TGCCTC`	1	--	us2k¹		6		NA CSA WA EA	363
rs5868824^1,2	C,F	--	75697559(+)	`CAGGG-/AAAAAA`	1	--	us2k¹ trp³		3		NA CSA	6
rs78788846^1,2		--	75697569(+)	`AAAAAT/AATATT`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for IQGAP2 (75699074 - 75949074 bp, first 250kb of IQGAP2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IQGAP2: --
Human Gene Mutation Database (HGMD): IQGAP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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IQGAP2 for disorders           About GeneDecksing

OMIM gene information: 605401    OMIM disorders: --

2 diseases for IQGAP2:    About MalaCards

gastric cancer carcinoma

Human Genome Epidemiology (HuGE) Navigator: IQGAP2 (6 documents)

Export disorders for IQGAP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IQGAP2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with IQGAP2)

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The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. (PubMed id 8756646)^{1, 2, 3} Brill S.... Snijders A.J. (1996)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
A genome-wide association study for age-related heari ng impairment in the Saami. (PubMed id 20068591)^{1, 9} Van Laer L....Van Camp G. (2010)
IQGAP2, A candidate tumour suppressor of prostate tumo rigenesis. (PubMed id 22406297)¹ Xie Y....Tang D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10788	HGNC: 6111	AceView: IQGAP2	Ensembl:ENSG00000145703	euGenes: HUgn10788
ECgene: IQGAP2	Kegg: 10788	H-InvDB: IQGAP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IQGAP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IQGAP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for IQGAP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IQGAP2 gene:
Search GeneIP for patents involving IQGAP2

GeneCards and IP:
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IQ motif containing GTPase activating protein 2

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IQGAP2 Gene

IQ motif containing GTPase activating protein 2

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