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IQGAP2 Gene

protein-coding   GIFtS: 61
GCID: GC05P075699

IQ Motif Containing GTPase Activating Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IQ Motif Containing GTPase Activating Protein 21 2
Ras GTPase-Activating-Like Protein IQGAP22

External Ids:    HGNC: 61111   Entrez Gene: 107882   Ensembl: ENSG000001457037   OMIM: 6054015   UniProtKB: Q135763   

Export aliases for IQGAP2 gene to outside databases

Previous GC identifers: GC05P074504 GC05P075933 GC05P075737 GC05P075783 GC05P075734 GC05P070906


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IQGAP2 Gene:
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology
domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell
adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. (provided by
RefSeq, Jul 2008)

GeneCards Summary for IQGAP2 Gene:
IQGAP2 (IQ motif containing GTPase activating protein 2) is a protein-coding gene. GO annotations related to this gene include actin binding and Ras GTPase activator activity. An important paralog of this gene is IQGAP3.

UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576
Function: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with
calmodulin

Gene Wiki entry for IQGAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IQGAP2 gene promoter:
         AML1a   Lmo2   MIF-1   Nkx2-5   LCR-F1   HNF-1A   POU2F1   POU2F1a   HNF-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQGAP2 promoter sequence
   Search Chromatin IP Primers for IQGAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q

IQGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQGAP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P075699:  view genomic region     (about GC identifiers)

Start:
75,699,074 bp from pter      End:
76,003,957 bp from pter
Size:
304,884 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576 (See protein sequence)
Recommended Name: Ras GTPase-activating-like protein IQGAP2  
Size: 1575 amino acids; 180578 Da
2 PDB 3D structures from and Proteopedia for IQGAP2:
3IEZ (3D)        4EZA (3D)    
Secondary accessions: A8K4V1 B7Z8A4
Alternative splicing: 2 isoforms:  Q13576-1   Q13576-2   

Explore the universe of human proteins at neXtProt for IQGAP2: NX_Q13576

Explore proteomics data for IQGAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IQGAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001272389.1  NP_001272390.1  NP_001272391.1  NP_006624.2  

    ENSEMBL proteins: 
     ENSP00000274364   ENSP00000423672   ENSP00000421097   ENSP00000422661   ENSP00000379535  
     ENSP00000425351   ENSP00000426027   ENSP00000423258   ENSP00000421319   ENSP00000425941  
     ENSP00000442313  

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    Cloud-Clone Corp. Proteins for IQGAP2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR000593 RasGAP_C
     IPR023152 RasGAP_CS
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry Q13576

    ProtoNet protein and cluster: Q13576

    5 Blocks protein domains:
    IPB000048 IQ calmodulin-binding region
    IPB000593 RasGAP protein
    IPB001715 Calponin-like actin-binding
    IPB001936 Ras GTPase-activating protein
    IPB011575 RasGAP


    UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 3 IQ domains
    Similarity: Contains 1 Ras-GAP domain
    Similarity: Contains 1 WW domain


    Find genes that share domains with IQGAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IQGA2_HUMAN, Q13576
    Function: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with
    calmodulin

         Genatlas biochemistry entry for IQGAP2:
    IQ motif containing GTPase activating protein 2,S pombe RasGAP-like protein SAR1 homolog,expressed in
    liver,potential effector for CDC42,may be involved in cell morphology

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding TAS8756646
    GO:0005095GTPase inhibitor activity TAS8756646
    GO:0005096GTPase activator activity ----
    GO:0005099Ras GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IQGAP2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Iqgap2):
     cellular  homeostasis/metabolism  liver/biliary system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with IQGAP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Iqgap2tm1Vs for IQGAP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IQGAP2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IQGAP2 (see all 18):
    hsa-miR-34b* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-25 hsa-miR-124 hsa-miR-548x hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidIQGAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IQGAP2

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    Addgene plasmids for IQGAP2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005874microtubule IDA--
    GO:0005902microvillus IEA--
    GO:0015629actin cytoskeleton TAS8756646
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with IQGAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IQGAP2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    3Actin Nucleation by ARP-WASP Complex
    CDC42 Pathway0.41
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    5G13 Signaling Pathway
    G13 Signaling Pathway


    Find genes that share SuperPaths with IQGAP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IQGAP2
        Rac1 Pathway
    CDC42 Pathway

    1 Cell Signaling Technology (CST) Pathway for IQGAP2
        Cytoskeletal Signaling

    2 BioSystems Pathways for IQGAP2
        G13 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 Kegg Pathway  (Kegg details for IQGAP2):
        Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Array including IQGAP2: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IQGAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IQGAP2 (Q135762, 3 ENSP000002743644) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48524 I2D: score=2 
    NFKBIBQ156532, 3MINT-47856 I2D: score=2 
    CALM1P621583, ENSP000003494674I2D: score=4 STRING: ENSP00000349467
    RELAQ042062, 3, ENSP000003842734MINT-48970 MINT-48010 I2D: score=1 STRING: ENSP00000384273
    CALM2P621583I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8756646
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0043086negative regulation of catalytic activity TAS8756646
    GO:0051056regulation of small GTPase mediated signal transduction ----

    Find genes that share ontologies with IQGAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IQGAP2 (IQGA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IQGAP2 gene (4 alternative transcripts): 
    NM_001285460.1  NM_001285461.1  NM_001285462.1  NM_006633.3  

    Unigene Cluster for IQGAP2:

    IQ motif containing GTPase activating protein 2
    Hs.291030  [show with all ESTs]
    Unigene Representative Sequence: NM_006633
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000274364(uc003kek.3) ENST00000514350 ENST00000505766(uc010izv.2)
    ENST00000504815 ENST00000514001 ENST00000396234(uc010izw.1) ENST00000509074
    ENST00000502745 ENST00000504254 ENST00000513534 ENST00000515505 ENST00000514579
    ENST00000512383 ENST00000504558 ENST00000504477 ENST00000509741 ENST00000512256
    ENST00000508410
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IQGAP2 (see all 18):
    hsa-miR-34b* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-25 hsa-miR-124 hsa-miR-548x hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidIQGAP2 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for IQGAP2 
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      QuantiFast Probe-based Assays in human, mouse, rat IQGAP2

    Additional mRNA sequence: 

    AB208856.1 AK291066.1 AK302510.1 AK302599.1 AK302981.1 AK303054.1 AK307555.1 AK307626.1 
    AK311619.1 AY351902.1 U51903.1 

    13 DOTS entries:

    DT.214996  DT.92431615  DT.92431622  DT.100673166  DT.307602  DT.100646205  DT.120839123  DT.40116757 
    DT.70101190  DT.75162310  DT.92431623  DT.95272389  DT.40230547 

    Selected AceView cDNA sequences (see all 175):

    BX110936 AW629087 BM674262 R82192 BP341853 CB155984 BM701302 CN479151 
    AI056799 BQ002800 CR601162 AI758590 AL039349 BP369201 BM837658 AV654864 
    BG776812 AI742058 BU952649 R82241 AI198939 BX092943 BG254526 AI480341 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^
    SP1:                                      -                                                                                               -     -               
    SP2:                                                                    -                                                                 -     -               
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c
    SP1:                                            -                           
    SP2:                                            -                           
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for IQGAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IQGAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGACTCT
    IQGAP2 Expression
    About this image


    IQGAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             hIPS1
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
    IQGAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IQGAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.291030

    UniProtKB/Swiss-Prot: IQGA2_HUMAN, Q13576
    Tissue specificity: Isoform 2 expression is enhanced in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including IQGAP2: 
              Cytoskeleton Regulators in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IQGAP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqgap21 , 5 IQ motif containing GTPase activating protein 21, 5 85.31(n)1
    89.02(a)1
      13 (50.26 cM)5
    5449631  NM_027711.11  NP_081987.11 
     956271775 
    chicken
    (Gallus gallus)
    Aves IQGAP21 IQ motif containing GTPase activating protein 2 73.97(n)
    74.33(a)
      427211  NM_001277778.1  NP_001264707.1 
    lizard
    (Anolis carolinensis)
    Reptilia IQGAP26
    IQ motif containing GTPase activating protein 2
    70(a)
    1 ↔ 1
    2(14222427-14348986)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB093561.12   -- 75.01(n)    AB093561.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iqgap21 IQ motif containing GTPase activating protein 2 64.82(n)
    63.85(a)
      563030  NM_001128340.1  NP_001121812.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pes-76
    Protein PES-7 (pes-7) mRNA, complete cds
    26(a)
    1 → many
    I(14263301-14271317) WBGene00003980
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IQG16
    Essential protein required for determination of bu...
    18(a)
    1 → many
    XVI(90622-95109) YPL242C


    ENSEMBL Gene Tree for IQGAP2 (if available)
    TreeFam Gene Tree for IQGAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IQGAP2 gene
    IQGAP32  IQGAP12  
    2 SIMAP similar genes for IQGAP2 using alignment to 10 protein entries:     IQGA2_HUMAN (see all proteins):
    IQGAP1    IQGAP3

    Find genes that share paralogs with IQGAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IQGAP2 (see all 6366)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903258961,2
    Cuntested175996952(+) GGGGCG/AAAGAG 2 /A syn11Minor allele frequency- A:0.00EU 1323
    rs709826041,2
    C--70933454(+) AAAAT-/TA/TT 
            
    ATATA
    1 -- int11NA 2
    rs716042891,2
    C--70933732(+) CACAG-/AC    
       
    /ACAC
    ACACA
    1 -- int11NA 2
    rs1905184301,2
    --75697207(+) GTTCAC/GAGTGA 1 -- us2k10--------
    rs1817585801,2
    C--75697266(+) TAAGTC/TATACA 1 -- us2k10--------
    rs1876530881,2
    C--75697289(+) TTGTTA/GTGTGT 1 -- us2k10--------
    rs1907802921,2
    --75697318(+) ACTTGA/GCAAAT 1 -- us2k10--------
    rs1392657251,2
    --75697374(+) ATCTCC/TTGACA 1 -- us2k10--------
    rs623632091,2
    C,F--75697439(+) TGCCGA/TGCCTC 1 -- us2k16Minor allele frequency- T:0.25NA CSA WA EA 363
    rs58688241,2
    C,F--75697559(+) CAGGG-/AAAAAA 1 -- us2k1 trp33Minor allele frequency- A:0.33NA CSA 6

    HapMap Linkage Disequilibrium report for IQGAP2 (75699074 - 75949074 bp, first 250kb of IQGAP2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IQGAP2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663233CNV Deletion23128226
    esv2730320CNV Deletion23290073
    esv2730321CNV Deletion23290073
    esv2730322CNV Deletion23290073
    nsv4884CNV Insertion18451855
    esv273773CNV Insertion20981092
    esv270101CNV Insertion20981092
    esv267756CNV Insertion20981092
    nsv4885CNV Insertion18451855
    nsv882206CNV Loss21882294

    Human Gene Mutation Database (HGMD): IQGAP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IQGAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for IQGAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605401    OMIM disorders: --


    Find genes that share disorders with IQGAP2           About GenesLikeMe

    Genetic Association Database (GAD): IQGAP2
    Human Genome Epidemiology (HuGE) Navigator: IQGAP2 (6 documents)

    Export disorders for IQGAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IQGAP2 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with IQGAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. (PubMed id 8756646)1, 2, 3 Brill S.... Snijders A.J. (Mol. Cell. Biol. 1996)
    2. A genome-wide association study for age-related hearing impairment in the Saami. (PubMed id 20068591)1, 4, 9 Van Laer L....Van Camp G. (Eur. J. Hum. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (N. Engl. J. Med. 2012)
    10. IQGAP2, A candidate tumour suppressor of prostate tumorigenesis. (PubMed id 22406297)1 Xie Y....Tang D. (Biochim. Biophys. Acta 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10788 HGNC: 6111 AceView: IQGAP2 Ensembl:ENSG00000145703 euGenes: HUgn10788
    ECgene: IQGAP2 Kegg: 10788 H-InvDB: IQGAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IQGAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IQGAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IQGAP2 gene:
    Search GeneIP for patents involving IQGAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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