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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQGAP1 Gene

protein-coding   GIFtS: 67
GCID: GC15P090931

IQ motif containing GTPase activating protein 1
 Explore 29 diseases affiliated with
IQGAP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IQGAP1    

Aliases
for IQGAP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
IQ Motif Containing GTPase Activating Protein 11 2     KIAA00511 3
P1951     Ras GTPase-Activating-Like Protein IQGAP12
SAR11 2 5     RasGAP-Like With IQ Motifs2
HUMORFA011 2     

External Ids:    HGNC: 61101   Entrez Gene: 88262   Ensembl: ENSG000001405757   OMIM: 6033795   UniProtKB: P469403   

Export aliases for IQGAP1 gene to outside databases

Previous GC identifers: GC15M087129 GC15P084438 GC15P088518 GC15P088661 GC15P088732 GC15P067043


Summaries
for IQGAP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IQGAP1:
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one
Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and
with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by
gene amplification in two gastric cancer cell lines. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IQGA1_HUMAN, P46940
Function: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could
serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals
to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth

Gene Wiki entry for IQGAP1


Genomic Views
for IQGAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQGAP1 gene promoter:
         HFH-3   Pax-5   Sp1   NRSF form 1   CUTL1   NRSF form 2   E47   FOXI1   IRF-7A   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IQGAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IQGAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQGAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

IQGAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQGAP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P090931:  view genomic region     (about GC identifiers)

Start:
 90,931,450 bp from pter      End:
 91,045,475 bp from pter
Size:
 114,026 bases      Orientation:
 plus strand

Proteins
for IQGAP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IQGA1_HUMAN, P46940 (See protein sequence)
Recommended Name: Ras GTPase-activating-like protein IQGAP1  
Size: 1657 amino acids; 189252 Da
Subunit: Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state.
Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6
Subcellular location: Cell membrane
Sequence caution: Sequence=BAA06123.2; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for IQGAP1:
1X0H (3D)        2RR8 (3D)        3FAY (3D)        3I6X (3D)    
Secondary accessions: A7MBM3

Explore the universe of human proteins at neXtProt for IQGAP1: NX_P46940

Post-translational modifications:

  • Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free
    • CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46940

    • IQGAP1 Protein expression data from MOPED and PaxDb:    About this image 
    IQGAP1 Protein Expression
    REFSEQ proteins: NP_003861.1  
    ENSEMBL proteins: 
     ENSP00000268182   ENSP00000453181   ENSP00000452723  
    Reactome Protein details: P46940
    Human Recombinant Protein Products for IQGAP1: 
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    Novus Biologicals IQGAP1 Protein
    Novus Biologicals IQGAP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IQGAP1

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005874microtubule IDA--

    IQGAP1 for ontologies           About GeneDecksing



    IQGAP1 Antibody Products: 
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    Uscn ELISAs and CLIAs for IQGAP1

    Protein Domains /
    Families
    for IQGAP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IQGAP1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR023152 RasGAP_CS
     IPR001936 RasGAP
     IPR001715 CH-domain
     IPR008936 Rho_GTPase_activation_prot
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry P46940

    ProtoNet protein and cluster: P46940

    5 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB000593 RasGAP protein
    IPB001715 Calponin-like actin-binding
    IPB001936 Ras GTPase-activating protein
    IPB011575 RasGAP


    UniProtKB/Swiss-Prot: IQGA1_HUMAN, P46940
    Domain: Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the
    phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of
    nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction
    between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free
    CDC42 on both C1 and C2
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 4 IQ domains
    Similarity: Contains 1 Ras-GAP domain
    Similarity: Contains 1 WW domain


    Function
    for IQGAP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IQGA1_HUMAN, P46940
    Function: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could
    serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals
    to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth

         Genatlas biochemistry entry for IQGAP1:
    IQ motif containing GTPase activating protein 1,S pombe RasGAP-like protein SAR1 homolog,potential effector for
    CDC42,may be involved in cell morphology

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity TAS8670801
    GO:0005096GTPase activator activity TAS8051149
    GO:0005099Ras GTPase activator activity IEA--
    GO:0005509calcium ion binding TAS18567582
    GO:0005515protein binding IPI--
         
    IQGAP1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for IQGAP1:
     Altered focal adhesion (FA) or  Decreased Hepatitis C virus re  Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased viability with pacli  Increased cell number in G1, s 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Iqgap1):
     digestive/alimentary  homeostasis/metabolism  mortality/aging  tumorigenesis 

    IQGAP1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Iqgap1tm1Aber for IQGAP1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IQGAP1 

    miRNA
    Products:            		miRTarBase miRNAs that target IQGAP1:
    hsa-mir-124 (MIRT002697)

    OriGene 3'-UTR Clone: IQGAP1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IQGAP1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate IQGAP1 (see all 22):
    hsa-miR-21* hsa-miR-3910 hsa-miR-520d-5p hsa-miR-410 hsa-miR-1304 hsa-miR-124 hsa-miR-3658 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: IQGAP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IQGAP1 (see all 7)
    OriGene shRNA RFP: IQGAP1
    OriGene siRNA: IQGAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IQGAP1
    Sirion Biotech Custom design and validation of potent shRNA sequences against IQGAP1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IQGAP1
    Sirion Biotech Customized adenovirus for overexpression of IQGAP1 
    Sirion Biotech Customized adenovirus for potent knockdown of IQGAP1

    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQGAP1


    Pathways & Interactions
    for IQGAP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Insulin Secretion
    		Regulation of Insulin Secretion1.00
    		Regulation of Insulin Secretion by Glucagon-like Peptide-10.55
    		Integration of energy metabolism0.74
    2Regulation of Actin Cytoskeleton
    		Regulation of Actin Cytoskeleton1.00
    		Regulation of actin cytoskeleton0.58
    3G-protein signaling_RAC1 in cellular process
    		RAC1 signaling pathway0.34
    		CDC42 signaling events0.17
    4Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    5Nephrin interactions
    		Nephrin interactions1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IQGAP1 (see all 6)
        Rac1 Pathway
    Remodeling of Adherens Junctions
    CDC42 Pathway
    Rho Family GTPases
    Germ Cell-Sertoli Cell Junction Dynamics

    1 Cell Signaling Technology (CST) Pathway for IQGAP1
        Cytoskeletal Signaling

    5/10 BioSystems Pathways for IQGAP1 (see all 10) 
        G13 Signaling Pathway
    Regulation of Actin Cytoskeleton
    CDC42 signaling events
    E-cadherin signaling in the nascent adherens junction
    RAC1 signaling pathway

    5/6        Reactome Pathways for IQGAP1 (see all 6)
        Nephrin interactions
    Regulation of Insulin Secretion by Glucagon-like Peptide-1
    Metabolism
    Regulation of Insulin Secretion
    Cell-Cell communication


    2         Kegg Pathways  (Kegg details for IQGAP1):
        Adherens junction
    Regulation of actin cytoskeleton


    IQGAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IQGAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/937 Interacting proteins for IQGAP1 (P469401, 2, 3 ENSP000002681824) via UniProtKB, MINT, STRING, and/or I2D (see all 937)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609531, 2, 3, ENSP000003144584EBI-297509,EBI-81752 MINT-14955 MINT-18637 MINT-18638 MINT-14956 MINT-14954 MINT-16570 MINT-18639 I2D: score=5 STRING: ENSP00000314458
    TSG101Q998162, 3, ENSP000002519684MINT-6169583 MINT-6173635 MINT-6173707 MINT-7945693 MINT-7947479 MINT-6173355 MINT-6173372 I2D: score=2 STRING: ENSP00000251968
    SHC1P293532, 3, ENSP000004013034MINT-7714840 MINT-7947479 MINT-7720048 I2D: score=2 STRING: ENSP00000401303
    RNASELQ058232, 3, ENSP000003565304MINT-7990598 MINT-7990574 I2D: score=1 STRING: ENSP00000356530
    YWHAZP631042, 3, ENSP000003095034MINT-3295639 MINT-3308248 I2D: score=1 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817regulation of cytokine production IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0007165signal transduction TAS8051149
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0035305negative regulation of dephosphorylation IEA--

    IQGAP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IQGAP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IQGAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQGAP1

    1 HMDB Compound for IQGAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    8 Novoseek chemical compound relationships for IQGAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zaldaride maleate 77.5 3 11734550 (2), 10608854 (1)
    gtp 45.6 5 9268338 (3), 9535855 (1), 17517894 (1)
    gdp 18.8 2 10473551 (1)
    oxygen 0 13 19366706 (4), 16179592 (1)
    calcium 0 18 9867866 (6), 15389538 (3), 16369480 (2), 12938160 (1) (see all 6)
    tyrosine 0 8 19366706 (2), 16763158 (1), 19050761 (1)
    glutamate 0 1 15695813 (1)
    serine 0 1 15994232 (1)

    Search CenterWatch for drugs/clinical trials and news about IQGAP1 / IQGA1 

    Transcripts
    for IQGAP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IQGAP1 gene: 
    NM_003870.3  

    Unigene Cluster for IQGAP1:

    IQ motif containing GTPase activating protein 1
    Hs.430551  [show with all ESTs]
    Unigene Representative Sequence: NM_003870
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268182(uc002bpl.1 uc010uqg.1) ENST00000560738 ENST00000560418
    ENST00000559809 ENST00000559682 ENST00000560373 ENST00000558003 ENST00000560733
    ENST00000560020 ENST00000560218 ENST00000558491 ENST00000561132 ENST00000561461
    ENST00000559031 ENST00000559674 ENST00000558957 ENST00000561086

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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate IQGAP1 (see all 22):
    hsa-miR-21* hsa-miR-3910 hsa-miR-520d-5p hsa-miR-410 hsa-miR-1304 hsa-miR-124 hsa-miR-3658 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: IQGAP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IQGAP1 (see all 7)
    OriGene shRNA RFP: IQGAP1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against IQGAP1 
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IQGAP1
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    Additional cDNA sequence: 

    AF401205.1 AK298000.1 AK304337.1 AK307643.1 AL110106.1 BC005906.1 BC016714.1 BC020549.1 
    BC037425.1 BC064971.1 BC089385.1 BC110811.1 BC139731.1 BC151834.1 D29640.1 

    24/29 DOTS entries (see all 29):

    DT.95103276  DT.449460  DT.100798322  DT.95109224  DT.121051845  DT.95103204  DT.95103189  DT.121051673 
    DT.40106179  DT.65287219  DT.87079162  DT.91638004  DT.95258017  DT.100725595  DT.100798326  DT.121051840 
    DT.121051888  DT.121051896  DT.121051907  DT.87046004  DT.91854296  DT.91961001  DT.95103218  DT.40208673 

    24/540 AceView cDNA sequences (see all 540):

    AA040189 CB132792 BX956233 AU279866 AW276565 AI709298 CB159393 AA453688 
    BQ920972 BE218724 AU280194 D29640 BG149970 AA436585 AL706224 AA779315 
    AA766837 BQ424156 BC064971 AU140951 AA360484 AL706189 AL698971 AA732487 

    GeneLoc Exon Structure


    Expression
    for IQGAP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQGAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTACTTC
    IQGAP1 Expression
    About this image

    IQGAP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IQGAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQGAP1

    SOURCE GeneReport for Unigene cluster: Hs.430551

    UniProtKB/Swiss-Prot: IQGA1_HUMAN, P46940
    Tissue specificity: Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver,
    skeletal muscle and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including IQGAP1: 
              Cytoskeleton Regulators in human mouse rat
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    Orthologs
    for IQGAP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IQGAP1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IQGAP11 IQ motif containing GTPase activating protein 1 79.11(n)
    88.76(a)    		   415591  XM_413959.3  XP_413959.3 
    lizard
    (Anolis carolinensis)    		 Reptilia IQGAP16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343941.1(38668-92808)
    African clawed frog
    (Xenopus laevis)    		 Amphibia XIQGAP12 IQ motif containing GTPase activating protein 1 76.86(n)    AB093560.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.176872 Transcribed sequence with moderate similarity to protein more 74.19(n)    CF996216.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 41(a)
    		 1 → many
    		 GroupUn.5(65937-74573)
    worm
    (Caenorhabditis elegans)    		 Secernentea pes-76
    		 Patterned Expression Site family member (pes-7)
    		 24(a)
    		 possible ortholog
    		 I(14263289-14271305)


    ENSEMBL Gene Tree for IQGAP1 (if available)
    TreeFam Gene Tree for IQGAP1 (if available) 

    Paralogs
    for IQGAP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQGAP1 gene
    IQGAP22  IQGAP32  
    2 SIMAP similar genes for IQGAP1 using alignment to 7 protein entries:     IQGA1_HUMAN (see all proteins):
    IQGAP3    IQGAP2

    IQGAP1 for paralogs           About GeneDecksing



    Genomic Variants
    for IQGAP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2154 NCBI SNPs in IQGAP1 are shown (see all 2154)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1812329911,2
    		--90929483(+) CTTTGA/TAGGCT 1 -- us2k10--------
    rs1141635901,2
    		--90929546(+) GTTTTC/TAAGTA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs26011881,2
    		C,F,A,H--90929563(+) ATAGTT/CTGAAG 1 -- us2k128Minor allele frequency- C:0.30NS EA NA WA CSA 2749
    rs1854830881,2
    		--90929825(+) AAACAC/GAGATT 1 -- us2k10--------
    rs26011891,2
    		C,F--90929874(+) ACTGGG/AAATTG 1 -- us2k16Minor allele frequency- A:0.31NA WA EA 364
    rs1475556181,2
    		--90929931(+) GACACG/TTGGGA 1 -- us2k10--------
    rs1882649131,2
    		--90930336(+) AGATCA/GCGCCA 1 -- us2k10--------
    rs1806714311,2
    		--90930374(+) AAACTC/TCGTCT 1 -- us2k10--------
    rs71812581,2
    		C,F--90930459(+) gcgggC/Tggatc 1 -- us2k14Minor allele frequency- T:0.50NA WA 8
    rs1918380341,2
    		--90930473(+) AGGTCA/GGGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IQGAP1 (90931450 - 91045475 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IQGAP1
         1 CNV: 8804
    Human Gene Mutation Database (HGMD): IQGAP1

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    Gastric Cancer
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    Disorders / Diseases
    for IQGAP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IQGAP1 for disorders           About GeneDecksing

    OMIM gene information: 603379    OMIM disorders: --

    20/29 diseases for IQGAP1 (see all 29):    About MalaCards
    gastric cancer    familial adenomatous polyposis    adenomatous polyposis coli    bullous skin disease
    anaplastic oligodendroglioma    polyposis    atopic dermatitis    oligodendroglioma
    skin disease    nephrotic syndrome    dermatitis    astrocytoma
    breast cancer    ischemia    endometrial cancer    lung adenocarcinoma
    carcinoma    adenocarcinoma    hepatocellular carcinoma    ovarian carcinoma

    10 Novoseek disease relationships for IQGAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 54 3 18560734 (1), 17085436 (1), 17255093 (1)
    colon carcinoma 34.3 2 11790459 (1), 11734550 (1)
    gastric cancer 15.4 7 15611933 (3), 18246045 (2), 11275980 (2)
    astrocytoma 13.4 2 12377780 (1), 11269942 (1)
    tumors 9.57 26 11275980 (3), 15655247 (2), 16387427 (2), 18541705 (1) (see all 9)
    cancer 0.41 7 19856315 (1), 17085436 (1), 17957782 (1), 19433088 (1) (see all 5)
    ischemia 0 1 16763158 (1)
    breast cancer 0 2 16930554 (1), 15521075 (1)
    adenocarcinoma 0 7 11027430 (3), 16387427 (3)
    carcinoma 0 7 11790459 (3), 12189501 (1), 15982217 (1)

    Human Genome Epidemiology (HuGE) Navigator: IQGAP1 (1 document)

    Export disorders for IQGAP1 gene to outside databases

    Publications
    for IQGAP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQGAP1 gene, integrated from 9 sources (see all 192):
    (articles sorted by number of sources associating them with IQGAP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human rasGAP-related protein containing calmodulin-binding motifs. (PubMed id 8051149)1, 2, 3, 9 Weissbach L.... Bernards A. (1994)
    2. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. (PubMed id 8670801)1, 2, 3 Hart M.J....Polakis P. (1996)
    3. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. (PubMed id 15695813)1, 2, 9 Li Z....Sacks D.B. (2005)
    4. Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. (PubMed id 15355962)1, 2, 9 Grohmanova K....Kroschewski R. (2004)
    5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2 Morita E....Sundquist W.I. (2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    8. Self-association of IQGAP1: characterization and functional sequelae. (PubMed id 16105843)1, 9 Ren J.G....Sacks D.B. (2005)
    9. IQGAP1 binds Rap1 and modulates its activity. (PubMed id 17517894)1, 9 Jeong H.W....Sacks D.B. (2007)
    10. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. (PubMed id 16135787)1, 9 Roy M....Sacks D.B. (2005)

    External Searches for IQGAP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IQGAP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8826 HGNC: 6110 AceView: IQGAP1 Ensembl:ENSG00000140575 euGenes: HUgn8826
    ECgene: IQGAP1 Kegg: 8826 H-InvDB: IQGAP1

    Other Databases showing IQGAP1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0051

    Specialized Databases showing IQGAP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQGAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IQGAP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IQGAP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IQGAP1 gene:
    Search GeneIP for patents involving IQGAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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