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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IQCK Gene

protein-coding GIFtS: 43
GCID: GC16P019727

IQ motif containing K

Search for IQCK
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
IQ Motif Containing K¹ ²
FLJ36575¹
MGC35048¹
IQ Domain-Containing Protein K²

External Ids:	HGNC: 28556¹	Entrez Gene: 124152²	Ensembl: ENSG00000174628⁷	UniProtKB: Q8N0W5³

Export aliases for IQCK gene to outside databases

Previous GC identifers: GC16P019636 GC16P018264

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IQCK gene promoter:
GCNF Roaz NF-AT AREB6 NF-AT4 NF-AT2 GCNF-1 NF-AT3 TGIF NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IQCK promoter sequence

Search SABiosciences Chromatin IP Primers for IQCK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.3

IQCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCK gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P019727: view genomic region (about GC identifiers)

Start:	19,727,778 bp from pter	End:	19,868,907 bp from pter
Size:	141,130 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IQCK_HUMAN, Q8N0W5 (See protein sequence)

Recommended Name: IQ domain-containing protein K

Size: 287 amino acids; 33292 Da

Secondary accessions: B2RDU0 O43327 Q8NFF4

Alternative splicing: 3 isoforms: Q8N0W5-1 Q8N0W5-2 Q8N0W5-3 (Gene prediction based on EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCK: NX_Q8N0W5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N0W5

IQCK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_694940.1

ENSEMBL proteins:

ENSP00000457519 ENSP00000309261 ENSP00000324901 ENSP00000456448 ENSP00000458669

ENSP00000458010 ENSP00000457506 ENSP00000455504 ENSP00000439344 ENSP00000406013

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N0W5

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IQCK

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IQCK (Q8N0W5³ ENSP00000324901⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA3	Q9Y6Q9³, ENSP00000361066⁴	I2D: score=1 STRING: ENSP00000361066

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IQCK
Search CenterWatch for drugs/clinical trials and news about IQCK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IQCK gene:

NM_153208.1

Unigene Cluster for IQCK:

IQ motif containing K

Hs.460217 [show with all ESTs]

Unigene Representative Sequence: AF520570

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000568126 ENST00000308214(uc002dgs.3) ENST00000320394(uc002dgr.3 uc010vat.2 uc010bwc.3 uc010vau.2)

ENST00000564955 ENST00000564186 ENST00000568300 ENST00000564515 ENST00000561839

ENST00000561935 ENST00000566312 ENST00000568387 ENST00000562762 ENST00000568236

ENST00000568061 ENST00000541926 ENST00000433597

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		hsa-miR-577 hsa-miR-498 hsa-miR-448 hsa-miR-607 hsa-miR-374b hsa-miR-513a-3p hsa-miR-26b* hsa-miR-374a

		SwitchGear 3'UTR luciferase reporter plasmid: IQCK 3' UTR sequence

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Additional cDNA sequence:

AF520569.1 AF520570.1 AK000122.1 AK093894.1 AK301933.1 AK303998.1 AK311216.1 AK315672.1

BC010515.1 BC034823.1

18 DOTS entries:

DT.80101804 DT.455202 DT.97779252 DT.100788420 DT.97773282 DT.120673352 DT.101959869 DT.97765274

DT.100738272 DT.100795604 DT.100795602 DT.100795605 DT.120673399 DT.91768747 DT.97843762 DT.120673204

DT.120673419 DT.95376011

24/156 AceView cDNA sequences (see all 156):

NM_153208 BF844466 BX339662 W39307 BM543564 AI674220 AA935710 AA868513

AF520570 BG900235 AA033543 AF520569 CB160734 CR605335 BC034823 AA812755

BI827236 BC010515 AA989072 BU789181 BE463593 AI655553 BI551982 AA913722

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IQCK (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	·	12d
SP1:													-		-		-				-						-
SP2:													-		-		-		-		-		-				-
SP3:							-						-		-		-				-						-
SP4:																					-						-
SP5:							-						-		-		-

ECgene alternative splicing isoforms for IQCK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IQCK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTACAGCC

About this image

IQCK expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IQCK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IQCK

SOURCE GeneReport for Unigene cluster: Hs.460217

SABiosciences Custom PCR Arrays for IQCK

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for IQCK gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Iqck^{1 , 5}	IQ motif containing K^{1, 5}	77.54(n)¹ 72.98(a)¹		7 (63.67 cM)⁵ 434232¹ NM_001081446.1¹ NP_001074915.1¹ 118855760⁵
chicken (Gallus gallus)	Aves	IQCK¹	IQ motif containing K	63.9(n) 58.06(a)		426993 XM_424597.3 XP_424597.3
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.14127²	Transcribed sequences	76.69(n)		BX725009.1
zebrafish (Danio rerio)	Actinopterygii	zgc:194423⁶	zgc:194423	34(a)	1 ↔ 1	3(63015915-63022904)
honey bee (Apis mellifera)	Insecta	--	--	26(a)	1 ↔ 1	Group14.2(560990-561954)

ENSEMBL Gene Tree for IQCK (if available)
TreeFam Gene Tree for IQCK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11546731^1,2	C	--	18262308(+)	`GTGTCC/TCCAAC`	1	--	us2k¹		1		NA	2
rs74013811^1,2	C,F,	--	18262944(+)	`GAGTGG/AGTGGT`	1	--	us2k¹		3		WA CSA	122
rs4780821^1,2	C	--	18264159(+)	`TACAAT/CGATAC`	1	--	us2k¹		2		NA	4
rs112819134^1,2	F,	--	18264459(+)	`GCCTGA/CGACAA`	1	--	int¹		4		CSA WA	123
rs13338725^1,2	C,	--	18266728(+)	`agcacA/C/Tccagg`	1	--	int¹		0	--	--	--	--
rs74013812^1,2	C,	--	18267050(+)	`AAACAG/CAAACT`	1	--	int¹		1		WA	2
rs76923266^1,2	C,F,	--	18267141(+)	`AGACCA/GTAAGC`	1	--	int¹		1		EA	120
rs11859190^1,2	C,F,H,	--	18267242(+)	`ctgaaA/Gataca`	1	--	int¹		3		NA WA	124
rs113675427^1,2		--	18267406(+)	`TCCCCA/CAAAAA`	1	--	int¹		2		CSA WA	120
rs73541444^1,2	C,	--	18267539(+)	`GGCTGG/TAATGC`	1	--	int¹		3		WA NA	240

HapMap Linkage Disequilibrium report for IQCK (19727778 - 19868907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IQCK: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IQCK for disorders About MalaCards

IQCK for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: IQCK (3 documents)

Export disorders for IQCK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IQCK gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with IQCK)

Utopia: connect your pdf to the dynamic
world of online information

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2, 3} Loftus B.J.... Adams M.D. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Tumor-suppressor role for the SPOP ubiquitin ligase i n signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. (PubMed id 21577200)¹ Li C....O'Malley B.W. (2011)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)¹ Speliotes E.K....Loos R.J. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)¹ Beausoleil S.A....Gygi S.P. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)¹ Andersen J.S.... Lamond A.I. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 124152	HGNC: 28556	AceView: MGC35048	Ensembl:ENSG00000174628	euGenes: HUgn124152
ECgene: IQCK	H-InvDB: IQCK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IQCK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IQCK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IQCK gene:
Search GeneIP for patents involving IQCK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ThermoFisher Antibody for IQCK

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCK

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IQCK gene at Home site.

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IQCK Gene

IQ motif containing K

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Export list of displayed genes

IQCK Gene

IQ motif containing K

Aliasesfor IQCK gene

Summariesfor IQCK gene

Genomic Viewsfor IQCK gene

Proteinsfor IQCK gene

Protein Domains /Familiesfor IQCK gene

Functionfor IQCK gene

Pathways & Interactionsfor IQCK gene

Drugs & Compoundsfor IQCK gene

Transcriptsfor IQCK gene

Expression for IQCK gene

Orthologsfor IQCK gene

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Genome Databases showing IQCK gene

Other Databases showing IQCK gene

Specialized Databases showing IQCK gene

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Aliases
for IQCK gene

Summaries
for IQCK gene

Genomic Views
for IQCK gene

Proteins
for IQCK gene

Protein Domains /
Families
for IQCK gene

Function
for IQCK gene

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for IQCK gene

Drugs & Compounds
for IQCK gene

Transcripts
for IQCK gene

Expression
for IQCK gene

Orthologs
for IQCK gene

Paralogs
for IQCK gene

Genomic Variants
for IQCK gene

Disorders / Diseases
for IQCK gene

Publications
for IQCK gene

Intellectual Property
for IQCK gene

Products
for IQCK gene