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Aliases for IQCK Gene

Aliases for IQCK Gene

  • IQ Motif Containing K 2 3 5

External Ids for IQCK Gene

Previous GeneCards Identifiers for IQCK Gene

  • GC16P019636
  • GC16P018264

Summaries for IQCK Gene

Entrez Gene Summary for IQCK Gene

  • This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for IQCK Gene

IQCK (IQ Motif Containing K) is a Protein Coding gene. Diseases associated with IQCK include Obsessive-Compulsive Disorder.

Additional gene information for IQCK Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCK Gene

Genomics for IQCK Gene

GeneHancer (GH) Regulatory Elements for IQCK Gene

Promoters and enhancers for IQCK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I019715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.9 +1.2 1223 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 KNOP1 IQCK RPS15A
GH16I019742 Enhancer 1 ENCODE dbSUPER 11.6 +27.1 27143 1.7 ELF3 FOXA2 ARID4B RAD21 THRB ZSCAN9 RARA MIXL1 EGR2 PPARG KNOP1 IQCK LOC105371115
GH16I019689 Enhancer 0.8 Ensembl ENCODE dbSUPER 12.1 -26.1 -26061 0.8 MITF ZNF335 GC16M019683 KNOP1 IQCK C16orf62 GC16M019687 GC16M019688
GH16I019829 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.6 +114.7 114719 2.9 FOSL1 JUND ZMYM3 HNF4A FOS ZNF600 ZNF24 KNOP1 IQCK LARP7P2 GPRC5B
GH16I019783 Enhancer 0.8 ENCODE dbSUPER 11.3 +68.2 68183 3.3 SOX5 SOX13 TFAP4 FOXA2 FOXA3 HLF NFYC NR2F2 FOXA1 ZKSCAN1 KNOP1 IQCK LOC105371115 LARP7P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCK gene promoter:

Genomic Locations for IQCK Gene

Genomic Locations for IQCK Gene
chr16:19,716,456-19,858,467
(GRCh38/hg38)
Size:
142,012 bases
Orientation:
Plus strand
chr16:19,727,778-19,868,907
(GRCh37/hg19)

Genomic View for IQCK Gene

Genes around IQCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCK Gene

Proteins for IQCK Gene

  • Protein details for IQCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0W5-IQCK_HUMAN
    Recommended name:
    IQ domain-containing protein K
    Protein Accession:
    Q8N0W5
    Secondary Accessions:
    • B2RDU0
    • O43327
    • Q8NFF4

    Protein attributes for IQCK Gene

    Size:
    287 amino acids
    Molecular mass:
    33292 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCK Gene

Post-translational modifications for IQCK Gene

No Post-translational modifications

No data available for DME Specific Peptides for IQCK Gene

Domains & Families for IQCK Gene

Gene Families for IQCK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCK Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IQCK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCK: view

No data available for UniProtKB/Swiss-Prot for IQCK Gene

Function for IQCK Gene

Phenotypes for IQCK Gene

genes like me logo Genes that share phenotypes with IQCK: view

miRNA for IQCK Gene

miRTarBase miRNAs that target IQCK

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCK Gene

Localization for IQCK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCK gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCK Gene

Pathways & Interactions for IQCK Gene

No Data Available

Interacting Proteins for IQCK Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324901%0d%0a9606.ENSP00000361066%0d%0a
Selected Interacting proteins: ENSP00000324901 Q8N0W5-IQCK_HUMAN for IQCK Gene via STRING IID

Gene Ontology (GO) - Biological Process for IQCK Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCK Gene

Drugs & Compounds for IQCK Gene

No Compound Related Data Available

Transcripts for IQCK Gene

Unigene Clusters for IQCK Gene

IQ motif containing K:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: -

Relevant External Links for IQCK Gene

GeneLoc Exon Structure for
IQCK
ECgene alternative splicing isoforms for
IQCK

Expression for IQCK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCK Gene

Protein differential expression in normal tissues from HIPED for IQCK Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCK Gene



Protein tissue co-expression partners for IQCK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCK Gene:

IQCK

SOURCE GeneReport for Unigene cluster for IQCK Gene:

Hs.460217
genes like me logo Genes that share expression patterns with IQCK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCK Gene

Orthologs for IQCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCK 33 34
  • 98.49 (n)
dog
(Canis familiaris)
Mammalia IQCK 33 34
  • 83.27 (n)
cow
(Bos Taurus)
Mammalia IQCK 33 34
  • 81.29 (n)
mouse
(Mus musculus)
Mammalia Iqck 33 16 34
  • 77.54 (n)
rat
(Rattus norvegicus)
Mammalia Iqck 33
  • 76.26 (n)
oppossum
(Monodelphis domestica)
Mammalia IQCK 34
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves IQCK 33 34
  • 71.78 (n)
lizard
(Anolis carolinensis)
Reptilia IQCK 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqck 33
  • 59.6 (n)
Str.14127 33
zebrafish
(Danio rerio)
Actinopterygii iqck 34
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for IQCK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCK Gene

ENSEMBL:
Gene Tree for IQCK (if available)
TreeFam:
Gene Tree for IQCK (if available)

Paralogs for IQCK Gene

(1) SIMAP similar genes for IQCK Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for IQCK Gene

genes like me logo Genes that share paralogs with IQCK: view

No data available for Paralogs for IQCK Gene

Variants for IQCK Gene

Sequence variations from dbSNP and Humsavar for IQCK Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000008565 -- 19,778,588(+) T/C intron_variant
rs1000014203 -- 19,754,741(+) G/A intron_variant
rs1000045238 -- 19,754,490(+) C/G intron_variant
rs1000053650 -- 19,816,139(+) G/A intron_variant
rs1000075448 -- 19,771,452(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCK Gene

Variant ID Type Subtype PubMed ID
esv275046 CNV gain+loss 21479260
esv2761903 CNV gain 21179565
nsv1037002 CNV gain 25217958
nsv1127474 CNV deletion 24896259
nsv1131230 CNV deletion 24896259
nsv428321 CNV loss 18775914
nsv436835 CNV insertion 17901297
nsv571582 CNV gain 21841781

Variation tolerance for IQCK Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.14; 93.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCK Gene

Human Gene Mutation Database (HGMD)
IQCK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCK Gene

Disorders for IQCK Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQCK Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
obsessive-compulsive disorder
  • ocd
- elite association - COSMIC cancer census association via MalaCards
Search IQCK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IQCK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IQCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQCK Gene

Publications for IQCK Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. (PMID: 24821223) Mattheisen M … Nestadt G (Molecular psychiatry 2015) 3 58

Products for IQCK Gene

Sources for IQCK Gene

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