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Aliases for IQCK Gene

Aliases for IQCK Gene

  • IQ Motif Containing K 2 3 5

External Ids for IQCK Gene

Previous GeneCards Identifiers for IQCK Gene

  • GC16P019636
  • GC16P018264

Summaries for IQCK Gene

Entrez Gene Summary for IQCK Gene

  • This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for IQCK Gene

IQCK (IQ Motif Containing K) is a Protein Coding gene. Diseases associated with IQCK include obsessive-compulsive disorder.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCK Gene

Genomics for IQCK Gene

Regulatory Elements for IQCK Gene

Promoters for IQCK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IQCK on UCSC Golden Path with GeneCards custom track

Genomic Location for IQCK Gene

Chromosome:
16
Start:
19,716,456 bp from pter
End:
19,858,467 bp from pter
Size:
142,012 bases
Orientation:
Plus strand

Genomic View for IQCK Gene

Genes around IQCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCK Gene

Proteins for IQCK Gene

  • Protein details for IQCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0W5-IQCK_HUMAN
    Recommended name:
    IQ domain-containing protein K
    Protein Accession:
    Q8N0W5
    Secondary Accessions:
    • B2RDU0
    • O43327
    • Q8NFF4

    Protein attributes for IQCK Gene

    Size:
    287 amino acids
    Molecular mass:
    33292 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCK Gene

Proteomics data for IQCK Gene at MOPED

Post-translational modifications for IQCK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCK Gene

Domains & Families for IQCK Gene

Protein Domains for IQCK Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IQCK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCK: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IQCK Gene

Function for IQCK Gene

Phenotypes for IQCK Gene

genes like me logo Genes that share phenotypes with IQCK: view

Animal Model Products

miRNA for IQCK Gene

miRTarBase miRNAs that target IQCK

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCK Gene

Localization for IQCK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IQCK Gene COMPARTMENTS Subcellular localization image for IQCK gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCK Gene

Pathways & Interactions for IQCK Gene

SuperPathways for IQCK Gene

No Data Available

Interacting Proteins for IQCK Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324901%0d%0a9606.ENSP00000361066%0d%0a
Selected Interacting proteins: ENSP00000324901 Q8N0W5-IQCK_HUMAN for IQCK Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IQCK Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCK Gene

Drugs & Compounds for IQCK Gene

No Compound Related Data Available

Transcripts for IQCK Gene

Unigene Clusters for IQCK Gene

IQ motif containing K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IQCK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7:
SP8: -

Relevant External Links for IQCK Gene

GeneLoc Exon Structure for
IQCK
ECgene alternative splicing isoforms for
IQCK

Expression for IQCK Gene

mRNA expression in normal human tissues for IQCK Gene

Protein differential expression in normal tissues from HIPED for IQCK Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCK Gene



SOURCE GeneReport for Unigene cluster for IQCK Gene Hs.460217

genes like me logo Genes that share expression patterns with IQCK: view

Protein tissue co-expression partners for IQCK Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IQCK Gene

Orthologs for IQCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IQCK 35
  • 81.29 (n)
  • 74.74 (a)
IQCK 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IQCK 35
  • 83.27 (n)
  • 77.82 (a)
IQCK 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iqck 35
  • 77.54 (n)
  • 72.98 (a)
Iqck 16
Iqck 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IQCK 35
  • 98.49 (n)
  • 97.56 (a)
IQCK 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iqck 35
  • 76.26 (n)
  • 71.23 (a)
oppossum
(Monodelphis domestica)
Mammalia IQCK 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves IQCK 35
  • 71.78 (n)
  • 72 (a)
IQCK 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQCK 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqck 35
  • 59.6 (n)
  • 56.28 (a)
Str.14127 35
zebrafish
(Danio rerio)
Actinopterygii iqck 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for IQCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCK Gene

ENSEMBL:
Gene Tree for IQCK (if available)
TreeFam:
Gene Tree for IQCK (if available)

Paralogs for IQCK Gene

(1) SIMAP similar genes for IQCK Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with IQCK: view

No data available for Paralogs for IQCK Gene

Variants for IQCK Gene

Sequence variations from dbSNP and Humsavar for IQCK Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs7191155 - 19,788,891(+) AGCCC(C/T)CTACA intron-variant, nc-transcript-variant, reference, missense
rs2729 -- 19,857,365(+) CCATG(C/G)TTTAC nc-transcript-variant, utr-variant-3-prime
rs227761 -- 19,849,983(+) TGTGC(C/T)GCACC intron-variant
rs227762 -- 19,848,084(+) aactc(A/G)ttttc intron-variant
rs227764 -- 19,858,069(+) ACACA(A/C/T)GCAGA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IQCK Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv428321 CNV Loss 18775914
esv275046 CNV Gain+Loss 21479260

Variation tolerance for IQCK Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.14; 93.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCK Gene

HapMap Linkage Disequilibrium report
IQCK
Human Gene Mutation Database (HGMD)
IQCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCK Gene

Disorders for IQCK Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQCK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
- elite association - COSMIC cancer census association via MalaCards
Search IQCK in MalaCards View complete list of genes associated with diseases

Relevant External Links for IQCK

Genetic Association Database (GAD)
IQCK
Human Genome Epidemiology (HuGE) Navigator
IQCK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCK
genes like me logo Genes that share disorders with IQCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQCK Gene

Publications for IQCK Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4 67
  2. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. (PMID: 24821223) Mattheisen M. … Nestadt G. (Mol. Psychiatry 2015) 3
  3. Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity. (PMID: 24788522) Hinney A. … . (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014) 3
  4. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. (PMID: 21577200) Li C. … O'Malley B.W. (Oncogene 2011) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for IQCK Gene

Sources for IQCK Gene

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