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Aliases for IQCJ-SCHIP1 Gene

Aliases for IQCJ-SCHIP1 Gene

  • IQCJ-SCHIP1 Readthrough 2 3 5

External Ids for IQCJ-SCHIP1 Gene

Previous GeneCards Identifiers for IQCJ-SCHIP1 Gene

  • GC03U901706
  • GC03P158681
  • GC03P158962

Summaries for IQCJ-SCHIP1 Gene

Entrez Gene Summary for IQCJ-SCHIP1 Gene

  • This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. The resulting fusion products are thought to be components of the multimolecular complexes of axon initial segments and nodes of Ranvier, and they may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010]

GeneCards Summary for IQCJ-SCHIP1 Gene

IQCJ-SCHIP1 (IQCJ-SCHIP1 Readthrough) is a Protein Coding gene. Diseases associated with IQCJ-SCHIP1 include Renal Cell Carcinoma, Papillary. GO annotations related to this gene include identical protein binding. An important paralog of this gene is SCHIP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCJ-SCHIP1 Gene

Genomics for IQCJ-SCHIP1 Gene

Regulatory Elements for IQCJ-SCHIP1 Gene

Enhancers for IQCJ-SCHIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IQCJ-SCHIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IQCJ-SCHIP1 Gene

Chromosome:
3
Start:
159,069,252 bp from pter
End:
159,897,366 bp from pter
Size:
828,115 bases
Orientation:
Plus strand

Genomic View for IQCJ-SCHIP1 Gene

Genes around IQCJ-SCHIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCJ-SCHIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCJ-SCHIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCJ-SCHIP1 Gene

Proteins for IQCJ-SCHIP1 Gene

  • Protein details for IQCJ-SCHIP1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    C9J366
    Recommended name:
    Protein IQCJ-SCHIP1
    Protein Accession:
    C9J366

    Protein attributes for IQCJ-SCHIP1 Gene

    Size:
    451 amino acids
    Molecular mass:
    49371 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IQCJ-SCHIP1 Gene

Post-translational modifications for IQCJ-SCHIP1 Gene

No Post-translational modifications

Other Protein References for IQCJ-SCHIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQCJ-SCHIP1 Gene

Domains & Families for IQCJ-SCHIP1 Gene

Protein Domains for IQCJ-SCHIP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCJ-SCHIP1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IQCJ-SCHIP1 Gene

Function for IQCJ-SCHIP1 Gene

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCJ-SCHIP1 Gene

Localization for IQCJ-SCHIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IQCJ-SCHIP1 Gene COMPARTMENTS Subcellular localization image for IQCJ-SCHIP1 gene
Compartment Confidence
cytoskeleton 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCJ-SCHIP1 Gene

Pathways & Interactions for IQCJ-SCHIP1 Gene

SuperPathways for IQCJ-SCHIP1 Gene

No Data Available

Interacting Proteins for IQCJ-SCHIP1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000420182%0d%0a9606.ENSP00000306245%0d%0a9606.ENSP00000404860%0d%0a9606.ENSP00000344666%0d%0a
Selected Interacting proteins: ENSP00000420182 for IQCJ-SCHIP1 Gene via STRING

Gene Ontology (GO) - Biological Process for IQCJ-SCHIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCJ-SCHIP1 Gene

Drugs & Compounds for IQCJ-SCHIP1 Gene

No Compound Related Data Available

Transcripts for IQCJ-SCHIP1 Gene

mRNA/cDNA for IQCJ-SCHIP1 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IQCJ-SCHIP1 Gene

No ASD Table

Relevant External Links for IQCJ-SCHIP1 Gene

GeneLoc Exon Structure for
IQCJ-SCHIP1
ECgene alternative splicing isoforms for
IQCJ-SCHIP1

Expression for IQCJ-SCHIP1 Gene

mRNA expression in normal human tissues for IQCJ-SCHIP1 Gene

mRNA differential expression in normal tissues according to GTEx for IQCJ-SCHIP1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).
genes like me logo Genes that share expression patterns with IQCJ-SCHIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IQCJ-SCHIP1 Gene

Orthologs for IQCJ-SCHIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCJ-SCHIP1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SCHIP1 34
  • 91.77 (n)
  • 93.07 (a)
mouse
(Mus musculus)
Mammalia Gm21949 34
  • 89.39 (n)
  • 92.13 (a)
Gm21949 16
chimpanzee
(Pan troglodytes)
Mammalia SCHIP1 34
  • 98.73 (n)
  • 99.16 (a)
rat
(Rattus norvegicus)
Mammalia Schip1 34
  • 89.94 (n)
  • 92.68 (a)
chicken
(Gallus gallus)
Aves SCHIP1 34
  • 74.79 (n)
  • 78.81 (a)
zebrafish
(Danio rerio)
Actinopterygii schip1 34
  • 78.62 (n)
  • 93.67 (a)
Species where no ortholog for IQCJ-SCHIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCJ-SCHIP1 Gene

ENSEMBL:
Gene Tree for IQCJ-SCHIP1 (if available)
TreeFam:
Gene Tree for IQCJ-SCHIP1 (if available)

Paralogs for IQCJ-SCHIP1 Gene

Paralogs for IQCJ-SCHIP1 Gene

(2) SIMAP similar genes for IQCJ-SCHIP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with IQCJ-SCHIP1: view

Variants for IQCJ-SCHIP1 Gene

Sequence variations from dbSNP and Humsavar for IQCJ-SCHIP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2595240 -- 159,270,805(+) GTTTA(C/T)ATAAA intron-variant
rs2621286 -- 159,269,746(-) AATCA(C/T)GGAGA intron-variant
rs12696092 -- 159,269,085(+) ATTGC(A/G/T)TGAGT intron-variant
rs9848338 -- 159,271,085(+) TGCAG(A/G)GAGCT intron-variant
rs13085667 -- 159,268,613(+) CATGA(A/T)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCJ-SCHIP1 Gene

Variant ID Type Subtype PubMed ID
dgv2626n106 CNV deletion 24896259
dgv2830e59 CNV tandem duplication 20981092
dgv834n67 CNV loss 20364138
esv1616680 CNV deletion 17803354
esv1917039 CNV deletion 18987734
esv2138340 CNV deletion 18987734
esv22799 CNV gain 19812545
esv23556 CNV loss 19812545
esv23950 CNV loss 19812545
esv24169 CNV loss 19812545
esv2421756 CNV deletion 20811451
esv24925 CNV loss 19812545
esv2516721 CNV insertion 19546169
esv2560522 CNV deletion 19546169
esv2644833 CNV deletion 19546169
esv2656480 CNV deletion 23128226
esv2657975 CNV deletion 23128226
esv2659056 CNV deletion 23128226
esv2664613 CNV deletion 23128226
esv2669077 CNV deletion 23128226
esv2674821 CNV deletion 23128226
esv2678454 CNV deletion 23128226
esv2726104 CNV deletion 23290073
esv2726105 CNV deletion 23290073
esv2726107 CNV deletion 23290073
esv2726108 CNV deletion 23290073
esv2762352 CNV gain 21179565
esv2832681 CNV deletion 24192839
esv3302886 CNV tandem duplication 20981092
esv3439768 CNV duplication 20981092
esv3562788 CNV deletion 23714750
esv3562790 CNV deletion 23714750
esv3562794 CNV deletion 23714750
esv3562796 CNV deletion 23714750
esv3569077 CNV loss 25503493
esv3584505 CNV gain 24956385
esv3598351 CNV loss 21293372
esv3598352 CNV loss 21293372
esv3598354 CNV loss 21293372
esv3598355 CNV gain 21293372
esv3598356 CNV loss 21293372
esv3598357 CNV loss 21293372
esv3598360 CNV loss 21293372
esv3598362 CNV loss 21293372
esv3598364 CNV loss 21293372
esv3598365 CNV loss 21293372
esv3598366 CNV loss 21293372
esv3598367 CNV loss 21293372
esv3598371 CNV loss 21293372
esv3598372 CNV loss 21293372
esv3598373 CNV loss 21293372
esv3893792 CNV loss 25118596
esv4370 CNV loss 18987735
esv5498 CNV gain 19470904
esv5527 OTHER inversion 19470904
esv9632 CNV gain 19470904
esv992343 CNV deletion 20482838
esv993836 CNV deletion 20482838
nsv1004124 CNV gain 25217958
nsv1004990 CNV gain 25217958
nsv1010336 CNV loss 25217958
nsv1010828 CNV gain 25217958
nsv1074105 CNV deletion 25765185
nsv1110953 OTHER inversion 24896259
nsv1114442 CNV deletion 24896259
nsv1117355 CNV tandem duplication 24896259
nsv1128001 CNV deletion 24896259
nsv1141979 OTHER inversion 24896259
nsv1142375 CNV tandem duplication 24896259
nsv1153194 CNV insertion 26484159
nsv4082 CNV insertion 18451855
nsv4083 CNV insertion 18451855
nsv4084 CNV deletion 18451855
nsv4085 CNV insertion 18451855
nsv4086 CNV deletion 18451855
nsv4087 CNV insertion 18451855
nsv437890 CNV loss 16468122
nsv470971 CNV gain 18288195
nsv474854 CNV novel sequence insertion 20440878
nsv474858 CNV novel sequence insertion 20440878
nsv475193 CNV novel sequence insertion 20440878
nsv478315 CNV novel sequence insertion 20440878
nsv511197 CNV loss 21212237
nsv513091 CNV loss 21212237
nsv519199 CNV loss 19592680
nsv522248 CNV loss 19592680
nsv592125 CNV loss 21841781
nsv592126 CNV loss 21841781
nsv592127 CNV loss 21841781
nsv818181 CNV loss 17921354
nsv820265 CNV gain 19587683
nsv821438 CNV deletion 20802225
nsv829769 CNV gain 17160897
nsv955578 CNV deletion 24416366
nsv979894 CNV duplication 23825009
nsv997776 CNV gain 25217958
nsv998949 CNV gain 25217958

Variation tolerance for IQCJ-SCHIP1 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCJ-SCHIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCJ-SCHIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCJ-SCHIP1 Gene

Disorders for IQCJ-SCHIP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IQCJ-SCHIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma, papillary, 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IQCJ-SCHIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCJ-SCHIP1
genes like me logo Genes that share disorders with IQCJ-SCHIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IQCJ-SCHIP1 Gene

Publications for IQCJ-SCHIP1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 65
  2. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 65
  3. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. (PMID: 18550753) Martin P.M. … Goutebroze L. (J. Neurosci. 2008) 3 65
  4. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. (PMID: 17045569) Kwasnicka-Crawford D.A. … Scherer S.W. (Biochem. Biophys. Res. Commun. 2006) 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65

Products for IQCJ-SCHIP1 Gene

Sources for IQCJ-SCHIP1 Gene

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