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IQCJ-SCHIP1 Gene

protein-coding   GIFtS: 24
GCID: GC03P158681

IQCJ-SCHIP1 Readthrough

  Search for IQCJ-SCHIP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IQCJ-SCHIP1 Readthrough1 2
IQ Motif Containing J-Schwannomin Interacting Protein 1 Fusion Protein2
IQ Motif Containing J-Schwannomin Interacting Protein 1 Read-Through
Transcript2

External Ids:    HGNC: 388421   Entrez Gene: 1005053852   Ensembl: ENSG000002505887   UniProtKB: C9J3664   UniProtKB: C9J6154   
UniProtKB: C9J6304   UniProtKB: C9JMW44   UniProtKB: C9JVF14   UniProtKB: C9JXR14   UniProtKB: C9K0A84   
UniProtKB: H7C4Z14   

Export aliases for IQCJ-SCHIP1 gene to outside databases

Previous GC identifer: GC03U901706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IQCJ-SCHIP1 Gene:
This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J
(IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript
variants that are composed of in-frame exons from each individual gene. The resulting fusion products are thought
to be components of the multimolecular complexes of axon initial segments and nodes of Ranvier, and they may play
a role in calcium-mediated responses. (provided by RefSeq, Oct 2010)

GeneCards Summary for IQCJ-SCHIP1 Gene:
IQCJ-SCHIP1 (IQCJ-SCHIP1 readthrough) is a protein-coding gene. An important paralog of this gene is SCHIP1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IQCJ-SCHIP1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQCJ-SCHIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25.33

IQCJ-SCHIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCJ-SCHIP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P158681:  view genomic region     (about GC identifiers)

Start:
158,680,024 bp from pter      End:
159,615,155 bp from pter
Size:
935,132 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/TrEMBL: C9J366 (See protein sequence)
Recommended Name: Protein IQCJ-SCHIP1  
Size: 451 amino acids; 49371 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9J615 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 143 amino acids; 15206 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9J630 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 168 amino acids; 17920 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9JMW4 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 91 amino acids; 10028 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9JVF1 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 153 amino acids; 16847 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9JXR1 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 158 amino acids; 17635 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: C9K0A8 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 101 amino acids; 11606 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7C4Z1 (See protein sequence)

Recommended Name: Protein IQCJ-SCHIP1  
Size: 100 amino acids; 11346 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001184042.1  NP_001184043.1  

ENSEMBL proteins: 
 ENSP00000419668   ENSP00000418692   ENSP00000420182   ENSP00000419349   ENSP00000419125  
 ENSP00000420478   ENSP00000337239   ENSP00000400942   ENSP00000436076   ENSP00000418452  
 ENSP00000417305   ENSP00000417080   ENSP00000418570  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR015649 SCHIP_1

Graphical View of Domain Structure for InterPro Entry C9J366
Graphical View of Domain Structure for InterPro Entry C9J615
Graphical View of Domain Structure for InterPro Entry C9J630
Graphical View of Domain Structure for InterPro Entry C9JMW4
Graphical View of Domain Structure for InterPro Entry C9JVF1
Graphical View of Domain Structure for InterPro Entry C9JXR1
Graphical View of Domain Structure for InterPro Entry C9K0A8
Graphical View of Domain Structure for InterPro Entry H7C4Z1

ProtoNet protein and cluster: C9J366


IQCJ-SCHIP1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0042802identical protein binding ----
     
IQCJ-SCHIP1 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----

IQCJ-SCHIP1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IQCJ-SCHIP1
Interactions:

    Search GeneGlobe Interaction Network for IQCJ-SCHIP1

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ----

IQCJ-SCHIP1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for IQCJ-SCHIP1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for IQCJ-SCHIP1 gene (2 alternative transcripts): 
NM_001197113.1  NM_001197114.1  

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000467442 ENST00000471575 ENST00000476809 ENST00000485419(uc003fcq.2 uc003fcr.2)
ENST00000483486 ENST00000481715 ENST00000488898 ENST00000337808(uc003fcs.2 uc003fct.2 uc021xgm.1)
ENST00000412423 ENST00000527095 ENST00000467377 ENST00000460298 ENST00000472451
ENST00000473061
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IQCJ-SCHIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IQCJ-SCHIP1 Expression
About this image

IQCJ-SCHIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for IQCJ-SCHIP1 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm219491 , 5 predicted gene, 219491 89.39(n)1
92.13(a)1
  35
1005053861  NM_001113419.21  NP_001106890.11 
 678922205 
chicken
(Gallus gallus)
Aves SCHIP11 schwannomin interacting protein 1 74.79(n)
78.81(a)
  425016  XM_004943518.1  XP_004943575.1 
lizard
(Anolis carolinensis)
Reptilia IQCJ-SCHIP16
IQCJ-SCHIP1 readthrough
69(a)
1 ↔ 1
3(13338468-13556842)
zebrafish
(Danio rerio)
Actinopterygii schip11 schwannomin interacting protein 1 78.62(n)
93.67(a)
  550605  NM_001017906.1  NP_001017906.1 
fruit fly
(Drosophila melanogaster)
Insecta CG53756
--
14(a)
1 → many
2L(10328200-10331116)


ENSEMBL Gene Tree for IQCJ-SCHIP1 (if available)
TreeFam Gene Tree for IQCJ-SCHIP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IQCJ-SCHIP1 gene
SCHIP12  
2 SIMAP similar genes for IQCJ-SCHIP1 using alignment to 8 protein entries:     C9J366_HUMAN (see all proteins):
SCHIP1    IQCJ

IQCJ-SCHIP1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IQCJ-SCHIP1 (see all 73)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1417519711,2
--158984681(+) CTTTTG/TGCTTA 2 -- int10--------
rs168300891,2
C,F,H--158984756(+) ATTATT/CATGAT 2 -- int114Minor allele frequency- C:0.06NA EA NS WA CSA 1236
rs133217701,2
C,F--158984835(+) TAGCAG/CCTCTG 2 -- int17Minor allele frequency- C:0.13NA EA 386
rs1909821281,2
--158984970(+) AACTAC/TAGCAC 2 -- int10--------
rs98270481,2
C,F,A,H--158985073(+) AAAAAC/TTGTGG 2 -- int121Minor allele frequency- T:0.24NA EA NS WA CSA 1982
rs1831438521,2
--158985226(+) ATAAAG/TTAAGC 2 -- int10--------
rs1875532151,2
C--158985269(+) ATTTTC/TCAGTT 2 -- int10--------
rs1928179021,2
--158985296(+) TCCTTC/TTGCAT 2 -- int10--------
rs1832800441,2
--158985463(+) CAACTG/TCTACC 2 -- int10--------
rs1477163001,2
--158985640(+) TGTCCC/TGGCAT 2 -- int10--------

HapMap Linkage Disequilibrium report for IQCJ-SCHIP1 (158680024 - 158930024 bp, first 250kb of IQCJ-SCHIP1)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for IQCJ-SCHIP1 (see all 52):    About this table    
Variant IDTypeSubtypePubMed ID
esv2656480CNV Deletion23128226
esv2674821CNV Deletion23128226
esv2669077CNV Deletion23128226
esv2678454CNV Deletion23128226
esv2560522CNV Deletion19546169
esv2644833CNV Deletion19546169
esv993836CNV Deletion20482838
esv2726104CNV Deletion23290073
esv1917039CNV Deletion18987734
esv2421756CNV Deletion20811451

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IQCJ-SCHIP1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IQCJ-SCHIP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  2. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
  3. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. (PubMed id 18550753)1 Martin P.M....Goutebroze L. (J. Neurosci. 2008)
  4. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. (PubMed id 17045569)1 Kwasnicka-Crawford D.A.... Scherer S.W. (Biochem. Biophys. Res. Commun. 2006)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100505385 HGNC: 38842 Ensembl:ENSG00000250588 euGenes: HUgn100505385 ECgene: IQCJ-SCHIP1
H-InvDB: IQCJ-SCHIP1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IQCJ-SCHIP1 gene:
Search GeneIP for patents involving IQCJ-SCHIP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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