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IQCJ Gene

protein-coding   GIFtS: 34
GCID: GC03P158680

IQ Motif Containing J

  Search for IQCJ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
IQ Motif Containing J1 2
Calmodulin Binding Protein2
IQ Domain-Containing Protein J2

External Ids:    HGNC: 324061   Entrez Gene: 6545022   Ensembl: ENSG000002142167   OMIM: 6116225   UniProtKB: Q1A5X63   
ORGUL members:         

Export aliases for IQCJ gene to outside databases

Previous GC identifers: GC03U900617 GC03P160269 GC03P156182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IQCJ Gene:
IQCJ (IQ motif containing J) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IQCJ gene promoter:
         FOXF2   Pax-6   CUTL1   HNF-1A   PPAR-alpha   POU2F1   POU2F1a   HNF-1   Msx-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IQCJ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQCJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.32   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25.32

IQCJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCJ gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P158680:  view genomic region     (about GC identifiers)

Start:
158,680,717 bp from pter      End:
158,984,096 bp from pter
Size:
303,380 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IQCJ_HUMAN, Q1A5X6 (See protein sequence)
Recommended Name: IQ domain-containing protein J  
Size: 159 amino acids; 18226 Da
Secondary accessions: B7ZMM2 B9EH97 Q1A5X5
Alternative splicing: 5 isoforms:  Q1A5X6-1   Q1A5X6-2   Q1A5X6-3   Q9P0W5-5   Q9P0W5-6   (Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein)

Explore the universe of human proteins at neXtProt for IQCJ: NX_Q1A5X6

Explore proteomics data for IQCJ at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IQCJ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001036170.1  NP_001036171.1  NP_001184029.1  

    ENSEMBL proteins: 
     ENSP00000380932   ENSP00000402153   ENSP00000418141  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q1A5X6

    UniProtKB/Swiss-Prot: IQCJ_HUMAN, Q1A5X6
    Similarity: Contains 1 IQ domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IQCJ
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IQCJ
    Interactions:

        Search GeneGlobe Interaction Network for IQCJ

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IQCJ (ENSP000004021534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IQCJ



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IQCJ gene (3 alternative transcripts): 
    NM_001042705.2  NM_001042706.2  NM_001197100.1  

    Unigene Cluster for IQCJ:

    IQ motif containing J
    Hs.570685  [show with all ESTs]
    Unigene Representative Sequence: NM_001042705
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481796 ENST00000397832(uc003fco.3) ENST00000451172 ENST00000482126(uc003fcp.2 uc010hvy.2)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AK309049.1 BC137464.1 BC137469.1 BC144658.1 DQ309553.1 DQ309554.1 

    6 DOTS entries:

    DT.101965956  DT.120918508  DT.120918531  DT.120918542  DT.120918444  DT.120918484 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IQCJ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTCTGT
    IQCJ Expression
    About this image

    IQCJ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IQCJ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.570685
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IQCJ gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcj1 , 5 IQ motif containing J1, 5 88.55(n)1
    88.89(a)1
      3 (31.31 cM)5
    2084261  NM_177585.31  NP_808253.11 
     678922205 
    chicken
    (Gallus gallus)
    Aves IQCJ6
    IQ motif containing J
    41(a)
    1 ↔ 1
    9(21810250-21844816)
    lizard
    (Anolis carolinensis)
    Reptilia IQCJ6
    IQ motif containing J
    66(a)
    1 ↔ 1
    3(13769265-13776180)
    zebrafish
    (Danio rerio)
    Actinopterygii IQCJ6
    IQ motif containing J
    45(a)
    1 ↔ 1
    15(1269157-1271288) ENSDARG00000094909


    ENSEMBL Gene Tree for IQCJ (if available)
    TreeFam Gene Tree for IQCJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IQCJ gene
    1 SIMAP similar gene for IQCJ using alignment to 1 protein entry:     IQCJ_HUMAN:
    IQCJ-SCHIP1

    IQCJ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for IQCJ:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656480CNV Deletion23128226
    esv2421756CNV Deletion20811451
    esv2726104CNV Deletion23290073
    esv2516721CNV Insertion19546169
    esv24169CNV Loss19812545
    esv23950CNV Loss19812545
    nsv437890CNV Loss16468122
    nsv877692CNV Loss21882294
    nsv470971CNV Gain18288195
    nsv877694CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611622    OMIM disorders: --


    IQCJ for disorders           About GeneDecksing


    Export disorders for IQCJ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IQCJ gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IQCJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. (PubMed id 17045569)1, 2, 3 Kwasnicka-Crawford D.A.... Scherer S.W. (Biochem. Biophys. Res. Commun. 2006)
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    3. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. (PubMed id 18550753)1 Martin P.M....Goutebroze L. (J. Neurosci. 2008)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 654502 HGNC: 32406 Ensembl:ENSG00000214216 euGenes: HUgn654502 ECgene: IQCJ
    H-InvDB: IQCJ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IQCJ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IQCJ gene:
    Search GeneIP for patents involving IQCJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse SwitchGear Promoter luciferase reporter plasmids for IQCJ
     Search ThermoFisher Antibodies for IQCJ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCJ
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IQCJ
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IQCJ
     LSBio Antibodies in human, mouse, rat for IQCJ
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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