IQCH Gene
protein-coding GIFtS : 43
GCID: GC15 P067547
IQ motif containing H
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Aliasesfor IQCH gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases IQ Motif Containing H 1 2 Testis Development Protein NYD-SP52 3 NYDSP52 5 FLJ124761 IQ Domain-Containing Protein H2
Export aliases for IQCH gene to outside databases Previous GC identifers: GC15P065335 GC15P044381
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Summariesfor IQCH gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: IQCH_HUMAN, Q86VS3 Function : May play a regulatory role in spermatogenesis
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Genomic Viewsfor IQCH gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IQCH gene promoter: MEF-2A Chx10 MyoD aMEF-2 C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for IQCH Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat IQCH
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q23 IQCH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P067547: view genomic region
(about GC identifiers )
Start:
67,547,138 bp from pter
End:
67,794,598 bp from pter
Size:
247,461 bases
Orientation:
plus strand
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Proteinsfor IQCH gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IQCH_HUMAN, Q86VS3 (See
protein sequence )Recommended Name: IQ domain-containing protein H Size : 1027 amino acids; 117349 Da
Secondary accessions : A8K8W3 C9JPR6 D6RJ88 Q4G0S6 Q8NEH9 Q9BWX2 Q9H9Y1 Q9UF88Alternative splicing : 5 isoforms : Q86VS3-1 Q86VS3-2 Q86VS3-3 Q86VS3-4 Q86VS3-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IQCH: NX_Q86VS3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86VS3 IQCH Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001026885.1 NP_073621.2 ENSEMBL proteins: ENSP00000427323 ENSP00000421223 ENSP00000336861 ENSP00000441306 ENSP00000453749 ENSP00000454387 ENSP00000457425 ENSP00000456293 ENSP00000351617 ENSP00000353419 ENSP00000444118 Human Recombinant Protein Products: IQCH Antibody Products: Assay Products for IQCH:
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Protein
Domains / Familiesfor IQCH gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IQCH for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q86VS3 ProtoNet protein and cluster: Q86VS3
UniProtKB/Swiss-Prot: IQCH_HUMAN, Q86VS3 Similarity : Contains 1 IQ domain
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Functionfor IQCH gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: IQCH_HUMAN, Q86VS3 Function : May play a regulatory role in spermatogenesis
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IQCH (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IQCH (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): IQCH (NM_001031715 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQCH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IQCH
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCH
1 GenomeRNAi human phenotype for IQCH :
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Pathways & Interactionsfor IQCH gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCH 1 Interacting protein for IQCH (Q86VS3 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor IQCH gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IQCH Search CenterWatch for drugs/clinical trials and news about IQCH
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Transcriptsfor IQCH gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IQCH gene (2 alternative transcripts): NM_001031715.2 NM_022784.2 Unigene Cluster for IQCH:
IQ motif containing H Hs.657894 [show with all ESTs ] Unigene Representative Sequence: NM_001031715 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000512104 (uc002aqm.3 ) ENST00000514049 (uc002aqp.2 ) ENST00000335894 (uc002aqo.2 )ENST00000535744 ENST00000559568 (uc002aqn.2 ) ENST00000560497 ENST00000561339 ENST00000560790 ENST00000559172 ENST00000561357 ENST00000558759 ENST00000358767 (uc010ujv.2 )ENST00000360277 ENST00000546225 (uc002aqq.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IQCH (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IQCH (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): IQCH (NM_001031715 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQCH Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IQCH
Additional cDNA sequence: AK022538.1 AK292478.1 AK304303.1 AL133556.1 AY014282.2 BC031041.1 BC039292.1 BC039463.1 BC048964.1
7 DOTS entries : DT.100744614 DT.92068075
DT.40117922 DT.75161554 DT.40251893 DT.97777131 DT.121065225 24/38 AceView cDNA sequences (see all 38 ):
BX956408 BC039463 BC048964 AK022538 AI221385 AL133556 AI188101 AA789195 NM_022784 AA256332 BI559655 BQ438595 AY014282 AA256333 BC039292 BI764702 AA760929 BU506641 BI828093 BX112800 BI830121 AU123240 BC031041 BI465049 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for IQCH About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · SP1 :                   -       -                             SP2 :       -   -   -               -       -             -   -         SP3 :       -   -   -   -       -       -       -                       SP4 :       -   -   -         -                                   SP5 :                                                   -  
ExUns: 22c ^ 23 SP1 :     SP2 :     SP3 :     SP4 :     SP5 : -    
ECgene alternative splicing isoforms for IQCH
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Expression for IQCH gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IQCH expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACCTTTGCTC
About this image IQCH expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See IQCH Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IQCH SOURCE GeneReport for Unigene cluster: Hs.657894 UniProtKB/Swiss-Prot: IQCH_HUMAN, Q86VS3 Tissue specificity : Expressed in fetal and adult testis, in germ cells but not somatic cells SABiosciences Custom PCR Arrays for IQCH Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IQCHBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IQCH QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IQCH QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IQCH In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCH
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Orthologsfor IQCH gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for IQCH gene from 5/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for IQCH (if available)TreeFam Gene Tree for IQCH (if available)
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Paralogsfor IQCH gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor IQCH gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IQCH (67547138 - 67794598 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IQCH: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IQCH
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Disorders
/ Diseasesfor IQCH gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IQCH for disorders About MalaCards
IQCH for disorders About GeneDecksing
OMIM gene information: 612523
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: IQCH (4 documents) Export disorders for IQCH gene to outside databases
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Publicationsfor IQCH gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IQCH gene integrated from 9 sources : (articles sorted by number of sources associating them with IQCH) Utopia : connect your pdf to the dynamic world of online information
Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis. (PubMed id 15897968) 1 , 2 Yin L.L.... Sha J.H. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462) 1 Elks C.E....Murray A. (2010) Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians. (PubMed id 18491143) 1 Kimura T....Inoko H. (2008) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 2 Zody M.C....Nusbaum C. (2006)
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External Searches for IQCH gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IQCH gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IQCH gene
(According to HUGE )
About This Section --
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Specialized Databases showing IQCH gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IQCH Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IQCH gene: Search GeneIP for patents involving IQCH GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IQCH gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for IQCH OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IQCH OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IQCH Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IQCH Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IQCH OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IQCH Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IQCH OriGene Custom Protein Services for IQCH OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IQCH QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IQCH QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat IQCH QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IQCH QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IQCH QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IQCH
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IQCH Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCH
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IQCH
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Aliases for IQCH
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