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Aliases for IQCH Gene

Aliases for IQCH Gene

  • IQ Motif Containing H 2 3 5
  • Testis Development Protein NYD-SP5 3 4
  • IQ Domain-Containing Protein H 3
  • NYDSP5 3

External Ids for IQCH Gene

Previous GeneCards Identifiers for IQCH Gene

  • GC15P065335
  • GC15P067547
  • GC15P044381

Summaries for IQCH Gene

GeneCards Summary for IQCH Gene

IQCH (IQ Motif Containing H) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQCH Gene

  • May play a regulatory role in spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCH Gene

Genomics for IQCH Gene

Regulatory Elements for IQCH Gene

Enhancers for IQCH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G067196 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -55.9 -55856 5.5 KLF17 ZNF2 ZNF366 CBX5 FOS ZNF391 CREM ZNF263 REST ZEB2 IQCH AAGAB MAP2K5 SMAD3 PIR40233 RPS24P16
GH15G067182 1.1 ENCODE dbSUPER 21.5 -67.8 -67806 9.3 PKNOX1 ARID4B RAD21 ZNF335 ZNF121 SCRT2 IKZF2 CEBPB PPARG ZNF623 IQCH AAGAB MAP2K5 PIR40233 PIR31395
GH15G067129 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -113.6 -113553 23.0 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SMAD3 SNORD16 AAGAB IQCH SKOR1 ENSG00000260773 PIR53240 PIR54457
GH15G067079 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -167.4 -167362 16.4 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A FEZF1 ZNF766 ZNF143 FOS AAGAB IQCH SMAD3 GC15P067699 GC15P068403
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQCH on UCSC Golden Path with GeneCards custom track

Promoters for IQCH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078357 -174 2000 CREB3L1 AGO1 DMAP1 FEZF1 YY1 ZNF143 SP3 NFYC ZNF610 GLIS1

Genomic Location for IQCH Gene

67,254,774 bp from pter
67,506,612 bp from pter
251,839 bases
Plus strand

Genomic View for IQCH Gene

Genes around IQCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCH Gene

Proteins for IQCH Gene

  • Protein details for IQCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ domain-containing protein H
    Protein Accession:
    Secondary Accessions:
    • A8K8W3
    • C9JPR6
    • D6RJ88
    • Q4G0S6
    • Q8NEH9
    • Q9BWX2
    • Q9H9Y1
    • Q9UF88

    Protein attributes for IQCH Gene

    1027 amino acids
    Molecular mass:
    117349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCH Gene


neXtProt entry for IQCH Gene

Post-translational modifications for IQCH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCH Gene

Domains & Families for IQCH Gene

Protein Domains for IQCH Gene

Suggested Antigen Peptide Sequences for IQCH Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCH: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IQCH Gene

Function for IQCH Gene

Molecular function for IQCH Gene

UniProtKB/Swiss-Prot Function:
May play a regulatory role in spermatogenesis.
genes like me logo Genes that share phenotypes with IQCH: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCH Gene

Localization for IQCH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCH gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCH Gene

Pathways & Interactions for IQCH Gene

No Data Available

Interacting Proteins for IQCH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000336861 Q86VS3-IQCH_HUMAN for IQCH Gene via STRING IID

Gene Ontology (GO) - Biological Process for IQCH Gene


No data available for Pathways by source and SIGNOR curated interactions for IQCH Gene

Drugs & Compounds for IQCH Gene

No Compound Related Data Available

Transcripts for IQCH Gene

Unigene Clusters for IQCH Gene

IQ motif containing H:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -

ExUns: 22c ^ 23
SP5: -

Relevant External Links for IQCH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCH Gene

mRNA differential expression in normal tissues according to GTEx for IQCH Gene

This gene is overexpressed in Testis (x10.6).

Protein differential expression in normal tissues from HIPED for IQCH Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCH Gene

Protein tissue co-expression partners for IQCH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCH Gene:


SOURCE GeneReport for Unigene cluster for IQCH Gene:


mRNA Expression by UniProt/SwissProt for IQCH Gene:

Tissue specificity: Expressed in fetal and adult testis, in germ cells but not somatic cells.
genes like me logo Genes that share expression patterns with IQCH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCH Gene

Orthologs for IQCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IQCH 34 35
  • 99.48 (n)
(Canis familiaris)
Mammalia IQCH 34 35
  • 88.09 (n)
(Bos Taurus)
Mammalia IQCH 34 35
  • 85.9 (n)
(Mus musculus)
Mammalia Iqch 34 16 35
  • 80.75 (n)
(Rattus norvegicus)
Mammalia Iqch 34
  • 79.4 (n)
(Monodelphis domestica)
Mammalia IQCH 35
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia IQCH 35
  • 42 (a)
(Gallus gallus)
Aves LOC415554 34
  • 66.56 (n)
  • 54 (a)
(Anolis carolinensis)
Reptilia IQCH 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqch 34
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13986 34
(Danio rerio)
Actinopterygii iqch 34 35
  • 54.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13356 34
Species where no ortholog for IQCH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCH Gene

Gene Tree for IQCH (if available)
Gene Tree for IQCH (if available)

Paralogs for IQCH Gene

No data available for Paralogs for IQCH Gene

Variants for IQCH Gene

Sequence variations from dbSNP and Humsavar for IQCH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000004452 -- 67,342,026(+) AGCAC(C/T)TTGGG intron-variant
rs1000031142 -- 67,436,569(+) CCTGG(C/T)GAGAA intron-variant
rs1000049406 -- 67,291,667(+) AAATA(C/T)CAGAG intron-variant
rs1000055887 -- 67,485,419(+) GAGAT(A/G)CATGC intron-variant
rs1000067544 -- 67,337,409(+) CTGAG(A/C)AGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCH Gene

Variant ID Type Subtype PubMed ID
esv2660716 CNV deletion 23128226
esv2663197 CNV deletion 23128226
esv2666605 CNV deletion 23128226
esv3307361 CNV mobile element insertion 20981092
esv3321784 CNV insertion 20981092
esv3337306 CNV insertion 20981092
esv3350012 CNV insertion 20981092
esv3636778 CNV loss 21293372
esv3636781 CNV loss 21293372
esv3636784 CNV loss 21293372
esv3636785 CNV loss 21293372
esv3636786 CNV loss 21293372
nsv1049980 CNV loss 25217958
nsv1129568 CNV tandem duplication 24896259
nsv471817 CNV novel sequence insertion 20440878
nsv473557 CNV novel sequence insertion 20440878
nsv827371 CNV loss 20364138
nsv827372 CNV loss 20364138

Variation tolerance for IQCH Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCH Gene

Disorders for IQCH Gene

Relevant External Links for IQCH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IQCH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCH Gene

Publications for IQCH Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 64
  3. Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians. (PMID: 18491143) Kimura T. … Inoko H. (Hum. Genet. 2008) 3 46 64
  4. Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis. (PMID: 15897968) Yin L.L. … Sha J.H. (Asian J. Androl. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for IQCH Gene

Sources for IQCH Gene

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