Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IQCH Gene

Aliases for IQCH Gene

  • IQ Motif Containing H 2 3 5
  • Testis Development Protein NYD-SP5 3 4
  • NYDSP5 3

External Ids for IQCH Gene

Previous GeneCards Identifiers for IQCH Gene

  • GC15P065335
  • GC15P067547
  • GC15P044381

Summaries for IQCH Gene

GeneCards Summary for IQCH Gene

IQCH (IQ Motif Containing H) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQCH Gene

  • May play a regulatory role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCH Gene

Genomics for IQCH Gene

Regulatory Elements for IQCH Gene

Enhancers for IQCH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IQCH on UCSC Golden Path with GeneCards custom track

Promoters for IQCH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IQCH on UCSC Golden Path with GeneCards custom track

Genomic Location for IQCH Gene

67,254,774 bp from pter
67,506,612 bp from pter
251,839 bases
Plus strand

Genomic View for IQCH Gene

Genes around IQCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCH Gene

Proteins for IQCH Gene

  • Protein details for IQCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ domain-containing protein H
    Protein Accession:
    Secondary Accessions:
    • A8K8W3
    • C9JPR6
    • D6RJ88
    • Q4G0S6
    • Q8NEH9
    • Q9BWX2
    • Q9H9Y1
    • Q9UF88

    Protein attributes for IQCH Gene

    1027 amino acids
    Molecular mass:
    117349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCH Gene


neXtProt entry for IQCH Gene

Proteomics data for IQCH Gene at MOPED

Post-translational modifications for IQCH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCH Gene

Domains & Families for IQCH Gene

Protein Domains for IQCH Gene


Suggested Antigen Peptide Sequences for IQCH Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Contains 1 IQ domain.
genes like me logo Genes that share domains with IQCH: view

No data available for Gene Families for IQCH Gene

Function for IQCH Gene

Molecular function for IQCH Gene

UniProtKB/Swiss-Prot Function:
May play a regulatory role in spermatogenesis.
genes like me logo Genes that share phenotypes with IQCH: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCH Gene

Localization for IQCH Gene

Subcellular locations from

Jensen Localization Image for IQCH Gene COMPARTMENTS Subcellular localization image for IQCH gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCH Gene

Pathways & Interactions for IQCH Gene

SuperPathways for IQCH Gene

No Data Available

Interacting Proteins for IQCH Gene

Selected Interacting proteins: Q86VS3-IQCH_HUMAN for IQCH Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IQCH Gene


No data available for Pathways by source and SIGNOR curated interactions for IQCH Gene

Drugs & Compounds for IQCH Gene

No Compound Related Data Available

Transcripts for IQCH Gene

Unigene Clusters for IQCH Gene

IQ motif containing H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IQCH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -

ExUns: 22c ^ 23
SP5: -

Relevant External Links for IQCH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCH Gene

mRNA expression in normal human tissues for IQCH Gene

mRNA differential expression in normal tissues according to GTEx for IQCH Gene

This gene is overexpressed in Testis (x10.6).

Protein differential expression in normal tissues from HIPED for IQCH Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCH Gene

SOURCE GeneReport for Unigene cluster for IQCH Gene Hs.657894

mRNA Expression by UniProt/SwissProt for IQCH Gene

Tissue specificity: Expressed in fetal and adult testis, in germ cells but not somatic cells.
genes like me logo Genes that share expression patterns with IQCH: view

Protein tissue co-expression partners for IQCH Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IQCH Gene

Orthologs for IQCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IQCH 35
  • 85.9 (n)
  • 79.22 (a)
  • 76 (a)
(Canis familiaris)
Mammalia IQCH 35
  • 88.09 (n)
  • 81.79 (a)
  • 81 (a)
(Mus musculus)
Mammalia Iqch 35
  • 80.75 (n)
  • 74.7 (a)
Iqch 16
Iqch 36
  • 70 (a)
(Pan troglodytes)
Mammalia IQCH 35
  • 99.48 (n)
  • 99.03 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Iqch 35
  • 79.4 (n)
  • 71.56 (a)
(Monodelphis domestica)
Mammalia IQCH 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia IQCH 36
  • 42 (a)
(Gallus gallus)
Aves LOC415554 35
  • 66.56 (n)
  • 57.33 (a)
  • 54 (a)
(Anolis carolinensis)
Reptilia IQCH 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqch 35
  • 58.2 (n)
  • 52.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13986 35
(Danio rerio)
Actinopterygii iqch 35
  • 54.18 (n)
  • 44.93 (a)
iqch 36
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13356 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for IQCH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCH Gene

Gene Tree for IQCH (if available)
Gene Tree for IQCH (if available)

Paralogs for IQCH Gene

No data available for Paralogs for IQCH Gene

Variants for IQCH Gene

Sequence variations from dbSNP and Humsavar for IQCH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_051077 -
rs5813432 -- 67,261,109(+) AAAAA(-/A/AA)GAATG intron-variant, upstream-variant-2KB
rs5813433 -- 67,268,947(+) AACAT(-/AAC)AACAA intron-variant
rs5813434 -- 67,310,126(+) AATTG(-/TTA)GAGAA intron-variant
rs5813436 -- 67,317,813(+) GGGCA(-/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCH Gene

Variant ID Type Subtype PubMed ID
nsv827371 CNV Loss 20364138
esv2666605 CNV Deletion 23128226
nsv827372 CNV Loss 20364138
esv271637 CNV Insertion 20981092
esv268324 CNV Insertion 20981092
esv2663197 CNV Deletion 23128226
esv2660716 CNV Deletion 23128226

Variation tolerance for IQCH Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IQCH Gene

Disorders for IQCH Gene

Relevant External Links for IQCH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IQCH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCH Gene

Publications for IQCH Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for IQCH Gene

Sources for IQCH Gene