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Aliases for IQCH Gene

Aliases for IQCH Gene

  • IQ Motif Containing H 2 3 5
  • Testis Development Protein NYD-SP5 3 4
  • IQ Domain-Containing Protein H 3
  • NYDSP5 3

External Ids for IQCH Gene

Previous GeneCards Identifiers for IQCH Gene

  • GC15P065335
  • GC15P067547
  • GC15P044381

Summaries for IQCH Gene

GeneCards Summary for IQCH Gene

IQCH (IQ Motif Containing H) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQCH Gene

  • May play a regulatory role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCH Gene

Genomics for IQCH Gene

Regulatory Elements for IQCH Gene

Enhancers for IQCH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F067171 1.7 FANTOM5 Ensembl ENCODE 17.3 -78.3 -78267 10.4 ATF1 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A GATA2 FOS SP3 YY2 ENSG00000260773 IQCH SMAD3 ZWILCH SNAPC5 TIPIN AAGAB SNORD16 MAP2K5 SKOR1
GH15F067196 1.5 FANTOM5 Ensembl ENCODE 19.2 -55.9 -55856 5.5 KLF17 ZNF2 ZNF366 CBX5 FOS ZNF391 CREM ZNF263 REST ZEB2 IQCH AAGAB MAP2K5 SMAD3 PIR40233 RPS24P16
GH15F067223 1 FANTOM5 ENCODE 22.4 -29.5 -29450 2.8 BCOR HINFP ZMYM3 ZBTB40 ZNF121 ZNF324 GATA3 ZNF766 FOXK2 SMARCA5 IQCH AAGAB MAP2K5 RPS24P16 PIR40233
GH15F067129 1.8 FANTOM5 Ensembl ENCODE 11.1 -113.6 -113553 23.0 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000260773 SNORD16 SMAD3 IQCH-AS1 AAGAB IQCH ZWILCH SKOR1 PIR53240 PIR54457
GH15F067095 1.8 FANTOM5 Ensembl ENCODE 10.8 -150.9 -150939 16.3 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PIAS1 SNORD16 RPL35AP32 SNAPC5 AAGAB IQCH SMAD3 IQCH-AS1 GC15P067911 GC15P067219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQCH on UCSC Golden Path with GeneCards custom track

Promoters for IQCH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000127618 -174 2400 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for IQCH Gene

Chromosome:
15
Start:
67,254,774 bp from pter
End:
67,506,612 bp from pter
Size:
251,839 bases
Orientation:
Plus strand

Genomic View for IQCH Gene

Genes around IQCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCH Gene

Proteins for IQCH Gene

  • Protein details for IQCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VS3-IQCH_HUMAN
    Recommended name:
    IQ domain-containing protein H
    Protein Accession:
    Q86VS3
    Secondary Accessions:
    • A8K8W3
    • C9JPR6
    • D6RJ88
    • Q4G0S6
    • Q8NEH9
    • Q9BWX2
    • Q9H9Y1
    • Q9UF88

    Protein attributes for IQCH Gene

    Size:
    1027 amino acids
    Molecular mass:
    117349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IQCH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCH Gene

Post-translational modifications for IQCH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCH Gene

Domains & Families for IQCH Gene

Protein Domains for IQCH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCH Gene

Graphical View of Domain Structure for InterPro Entry

Q86VS3

UniProtKB/Swiss-Prot:

IQCH_HUMAN :
  • Contains 1 IQ domain.
Domain:
  • Contains 1 IQ domain.
genes like me logo Genes that share domains with IQCH: view

No data available for Gene Families for IQCH Gene

Function for IQCH Gene

Molecular function for IQCH Gene

UniProtKB/Swiss-Prot Function:
May play a regulatory role in spermatogenesis.
genes like me logo Genes that share phenotypes with IQCH: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCH Gene

Localization for IQCH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCH gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCH Gene

Pathways & Interactions for IQCH Gene

No Data Available

Interacting Proteins for IQCH Gene

Selected Interacting proteins: Q86VS3-IQCH_HUMAN for IQCH Gene via IID

Gene Ontology (GO) - Biological Process for IQCH Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCH Gene

Transcripts for IQCH Gene

Unigene Clusters for IQCH Gene

IQ motif containing H:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: -

ExUns: 22c ^ 23
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for IQCH Gene

GeneLoc Exon Structure for
IQCH
ECgene alternative splicing isoforms for
IQCH

Expression for IQCH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQCH Gene

mRNA differential expression in normal tissues according to GTEx for IQCH Gene

This gene is overexpressed in Testis (x10.6).

Protein differential expression in normal tissues from HIPED for IQCH Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCH Gene



Protein tissue co-expression partners for IQCH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCH Gene:

IQCH

SOURCE GeneReport for Unigene cluster for IQCH Gene:

Hs.657894

mRNA Expression by UniProt/SwissProt for IQCH Gene:

Q86VS3-IQCH_HUMAN
Tissue specificity: Expressed in fetal and adult testis, in germ cells but not somatic cells.
genes like me logo Genes that share expression patterns with IQCH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IQCH Gene

Orthologs for IQCH Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCH 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia IQCH 34 35
  • 88.09 (n)
cow
(Bos Taurus)
Mammalia IQCH 34 35
  • 85.9 (n)
mouse
(Mus musculus)
Mammalia Iqch 34 16 35
  • 80.75 (n)
rat
(Rattus norvegicus)
Mammalia Iqch 34
  • 79.4 (n)
oppossum
(Monodelphis domestica)
Mammalia IQCH 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQCH 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC415554 34
  • 66.56 (n)
IQCH 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQCH 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqch 34
  • 58.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13986 34
zebrafish
(Danio rerio)
Actinopterygii iqch 34 35
  • 54.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13356 34
Species where no ortholog for IQCH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCH Gene

ENSEMBL:
Gene Tree for IQCH (if available)
TreeFam:
Gene Tree for IQCH (if available)

Paralogs for IQCH Gene

No data available for Paralogs for IQCH Gene

Variants for IQCH Gene

Sequence variations from dbSNP and Humsavar for IQCH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10152913 -- 67,354,990(+) TGCTC(A/T)CTGCT intron-variant
rs10152922 -- 67,280,853(+) tatta(C/T)tatta intron-variant
rs10152973 -- 67,354,880(+) GCTTC(C/T)GCAGC intron-variant
rs10163085 -- 67,338,574(+) ACACA(C/G)GTCCA intron-variant
rs1020358 -- 67,309,273(-) TTTTA(A/G)ATGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCH Gene

Variant ID Type Subtype PubMed ID
nsv827372 CNV loss 20364138
nsv827371 CNV loss 20364138
nsv473557 CNV novel sequence insertion 20440878
nsv471817 CNV novel sequence insertion 20440878
nsv1129568 CNV tandem duplication 24896259
nsv1049980 CNV loss 25217958
esv3636786 CNV loss 21293372
esv3636785 CNV loss 21293372
esv3636784 CNV loss 21293372
esv3636781 CNV loss 21293372
esv3636778 CNV loss 21293372
esv3350012 CNV insertion 20981092
esv3337306 CNV insertion 20981092
esv3321784 CNV insertion 20981092
esv3307361 CNV mobile element insertion 20981092
esv2666605 CNV deletion 23128226
esv2663197 CNV deletion 23128226
esv2660716 CNV deletion 23128226

Variation tolerance for IQCH Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCH Gene

Disorders for IQCH Gene

Relevant External Links for IQCH

Genetic Association Database (GAD)
IQCH
Human Genome Epidemiology (HuGE) Navigator
IQCH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCH

No disorders were found for IQCH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCH Gene

Publications for IQCH Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 64
  3. Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians. (PMID: 18491143) Kimura T. … Inoko H. (Hum. Genet. 2008) 3 46 64
  4. Identification of a novel testis-specific gene and its potential roles in testis development/spermatogenesis. (PMID: 15897968) Yin L.L. … Sha J.H. (Asian J. Androl. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for IQCH Gene

Sources for IQCH Gene

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