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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCG Gene

protein-coding   GIFtS: 45
GCID: GC03M197615

IQ motif containing G

  Search for IQCG
in our new
 Human Malady Compendium 
Biological research products
for IQCG
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
IQ Motif Containing G1 2
DKFZp434B2271
IQ Domain-Containing Protein G2

External Ids:    HGNC: 252511   Entrez Gene: 842232   Ensembl: ENSG000001144737   OMIM: 6124775   UniProtKB: Q9H0953   

Export aliases for IQCG gene to outside databases

Previous GC identifers: GC03M199105 GC03M194918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCG gene promoter:
         AREB6   AhR   MEF-2A   aMEF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCG promoter sequence
   Search SABiosciences Chromatin IP Primers for IQCG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

IQCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M197615:  view genomic region     (about GC identifiers)

Start:
197,615,946 bp from pter      End:
197,687,013 bp from pter
Size:
71,068 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IQCG_HUMAN, Q9H095 (See protein sequence)
Recommended Name: IQ domain-containing protein G  
Size: 443 amino acids; 51918 Da
Secondary accessions: Q9BST2 Q9HAG8
Alternative splicing: 2 isoforms:  Q9H095-1   Q9H095-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCG: NX_Q9H095

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H095

  • IQCG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127907.1  NP_115639.1  

    ENSEMBL proteins: 
     ENSP00000265239   ENSP00000407736   ENSP00000389897   ENSP00000406411   ENSP00000393743  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IQCG for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q9H095

    ProtoNet protein and cluster: Q9H095

    UniProtKB/Swiss-Prot: IQCG_HUMAN, Q9H095
    Similarity: Contains 1 IQ domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCG

    2 Interacting proteins for IQCG (Q9H0952, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257350 I2D: score=2 
    BAG6P463793I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCG
    Search CenterWatch for drugs/clinical trials and news about IQCG 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IQCG gene (2 alternative transcripts): 
    NM_001134435.2  NM_032263.3  

    Unigene Cluster for IQCG:

    IQ motif containing G
    Hs.591675  [show with all ESTs]
    Unigene Representative Sequence: AK095094
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265239(uc003fyp.3) ENST00000455191(uc003fyo.3) ENST00000490748(uc003fyn.3)
    ENST00000478903 ENST00000485787 ENST00000469822 ENST00000473225 ENST00000453254(uc003fyq.4)
    ENST00000416896 ENST00000480302 ENST00000463651 ENST00000452735 ENST00000493624


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    Additional cDNA sequence: 

    AK021729.1 AK027224.1 AK095094.1 AK096574.1 AL136889.1 BC004816.1 BC016156.1 BC068973.1 
    BC136253.1 CR533515.1 

    12 DOTS entries:

    DT.309217  DT.87017877  DT.97802270  DT.91750441  DT.95196576  DT.101979640  DT.95370440  DT.91750440 
    DT.100811240  DT.100741891  DT.95370439  DT.120919030 

    24/123 AceView cDNA sequences (see all 123):

    AV708221 AL136889 NM_032263 AI859303 BG211682 AL041282 AI190567 BX439227 
    CR611369 BQ267461 AI564338 AI564330 AU117778 W74751 AW450885 CR533515 
    BM718323 AA043561 BC068973 AW880394 BE256850 BM908080 AK021729 AI914033 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IQCG (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ·
    SP1:                                -     -     -     -                 -     -                                         -                                       
    SP2:                                                                    -     -                                         -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                                    -     -                                                                                 
    SP5:        -     -                 -     -     -     -                 -     -                                                                                 

    ExUns: 15c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for IQCG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACCAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    IQCG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    Posterior foregut-like cells (A scalable, suspensi...)

    See IQCG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCG

    SOURCE GeneReport for Unigene cluster: Hs.591675
        SABiosciences Custom PCR Arrays for IQCG
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IQCG gene from 3/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IQCG1 IQ motif containing G 55.24(n)
    42.27(a)
      424923  XM_422733.3  XP_422733.1 
    lizard
    (Anolis carolinensis)
    Reptilia IQCG6
    --
    43(a)
    1 ↔ 1
    GL343433.1(430943-444671)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-222m18.31 si:ch211-222m18.3 52.93(n)
    40.5(a)
      100322600  XM_002665355.2  XP_002665401.1 


    ENSEMBL Gene Tree for IQCG (if available)
    TreeFam Gene Tree for IQCG (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQCG gene
    IQCD2  

    IQCG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1298 NCBI SNPs in IQCG are shown (see all 1298    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819945961,2
    --197615471(+) ACTGAA/GCTTTA 2 -- int1 ds50010--------
    rs1131700871,2
    C,--197615655(+) GCCAGG/ACACAA 2 -- ds5001 int12Minor allele frequency- A:0.05CSA WA 120
    rs1495992621,2
    --197615698(+) ATCTTA/GACACT 2 -- int1 ds50010--------
    rs1154907351,2
    F,--197615714(+) AAGTGG/AGGATT 2 -- int1 ds50011Minor allele frequency- A:0.10WA 118
    rs1857343281,2
    --197615764(+) CTAGCC/GTTCCA 2 -- int1 ds50010--------
    rs1889468161,2
    --197615970(+) CCAACA/GTTTAT 2 -- ut310--------
    rs1450605641,2
    --197615971(+) CAACAA/TTTATT 2 -- ut310--------
    rs1387880521,2
    --197616035(+) TTCCTA/GCTGAA 2 -- ut310--------
    rs1810512201,2
    --197616128(+) AATGCA/GTCACT 2 -- ut310--------
    rs745931771,2
    C,F,--197616209(+) AGAAAC/GTTCTT 2 -- ut311Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for IQCG (197615946 - 197687013 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for IQCG
         3 CNVs: 6232 0044 8440
         2 Indels: 46385 46384

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IQCG for disorders           About MalaCards

    IQCG for disorders           About GeneDecksing

    OMIM gene information: 612477    OMIM disorders: --


    Export disorders for IQCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQCG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84223 HGNC: 25251 AceView: DKFZp434B227 Ensembl:ENSG00000114473 euGenes: HUgn84223
    ECgene: IQCG H-InvDB: IQCG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQCG gene:
    Search GeneIP for patents involving IQCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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     IQCG Proteins, Antibodies, CLIAs, and ELISAs
     Cell Line associated with IQCG: PureStem ES-210, Ecto-ntu Progenitor
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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