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Aliases for IQCG Gene

Aliases for IQCG Gene

  • IQ Motif Containing G 2 3 5
  • Dynein Regulatory Complex Subunit 9 2 3
  • IQ Domain-Containing Protein G 3
  • CFAP122 3
  • DRC9 3

External Ids for IQCG Gene

Previous GeneCards Identifiers for IQCG Gene

  • GC03M199105
  • GC03M197615
  • GC03M194918

Summaries for IQCG Gene

GeneCards Summary for IQCG Gene

IQCG (IQ Motif Containing G) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IQCG Gene

  • Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCG Gene

Genomics for IQCG Gene

Regulatory Elements for IQCG Gene

Enhancers for IQCG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F197905 1.2 Ensembl ENCODE 19.1 +53.6 53648 1.6 PKNOX1 SIN3A BRCA1 ZNF2 GLIS2 ELK1 ZNF143 FOS SP5 JUNB IQCG RPL35A RNU6-858P
GH03F197956 1.1 ENCODE 12.8 +0.9 936 6.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 ENSG00000234742 LRCH3 LOC220729 IQCG ENSG00000249626 RPL35A
GH03F197948 1.1 ENCODE 12.3 +9.3 9271 3.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000234742 ENSG00000249626 LOC220729 LRCH3 IQCG RPL35A
GH03F197710 1.7 FANTOM5 Ensembl ENCODE 6.7 +247.2 247195 4.4 HDGF PKNOX1 ATF1 SIN3A BRCA1 ZNF121 GATA2 CBX5 FOS ZNF263 LOC220729 ENSG00000249626 IQCG LRCH3 PIR54031 FYTTD1
GH03F197748 1.4 FANTOM5 ENCODE 6.6 +209.8 209803 4.3 PKNOX1 CREB3L1 SIN3A YBX1 ZNF2 YY1 CBX5 ZNF143 ZNF207 FOS ENSG00000234742 ENSG00000230732 LRCH3 ENSG00000249626 LOC220729 IQCG FYTTD1 RUBCN MIR922 GC03P197788
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQCG on UCSC Golden Path with GeneCards custom track

Promoters for IQCG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001384263 -558 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 ZNF143

Genomic Location for IQCG Gene

Chromosome:
3
Start:
197,887,208 bp from pter
End:
197,960,142 bp from pter
Size:
72,935 bases
Orientation:
Minus strand

Genomic View for IQCG Gene

Genes around IQCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCG Gene

Proteins for IQCG Gene

  • Protein details for IQCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H095-IQCG_HUMAN
    Recommended name:
    IQ domain-containing protein G
    Protein Accession:
    Q9H095
    Secondary Accessions:
    • Q9BST2
    • Q9HAG8

    Protein attributes for IQCG Gene

    Size:
    443 amino acids
    Molecular mass:
    51918 Da
    Quaternary structure:
    • Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca(2+). Interacts with the HSP70 proteins HSPA1L and HSPA8 (PubMed:24787902). May form a complex with CAMK4 and HSP70 (By similarity).

    Three dimensional structures from OCA and Proteopedia for IQCG Gene

    Alternative splice isoforms for IQCG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCG Gene

Post-translational modifications for IQCG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCG Gene

Domains & Families for IQCG Gene

Gene Families for IQCG Gene

Protein Domains for IQCG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCG Gene

Graphical View of Domain Structure for InterPro Entry

Q9H095

UniProtKB/Swiss-Prot:

IQCG_HUMAN :
  • The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.
Domain:
  • The IQ domain mediates interaction with calmodulin when cellular Ca(2+) levels are low.
  • Contains 1 IQ domain.
genes like me logo Genes that share domains with IQCG: view

Function for IQCG Gene

Molecular function for IQCG Gene

UniProtKB/Swiss-Prot Function:
Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.

Gene Ontology (GO) - Molecular Function for IQCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA,IDA 24787902
GO:0030544 Hsp70 protein binding IPI 24787902
genes like me logo Genes that share ontologies with IQCG: view
genes like me logo Genes that share phenotypes with IQCG: view

Animal Models for IQCG Gene

MGI Knock Outs for IQCG:
  • Iqcg tm1b(EUCOMM)Wtsi

Animal Model Products

Inhibitory RNA Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IQCG Gene

Localization for IQCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for IQCG Gene

Cytoplasm. Cell projection, cilium, flagellum. Cell projection, cilium. Cytoplasm, cytoskeleton. Note=First detected the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct. {ECO:0000250 UniProtKB:Q80W32}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCG gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 3
peroxisome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for IQCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002177 manchette ISS --
GO:0005737 cytoplasm IEA,IDA 24787902
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
GO:0031514 motile cilium ISS --
genes like me logo Genes that share ontologies with IQCG: view

Pathways & Interactions for IQCG Gene

No Data Available

Interacting Proteins for IQCG Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265239%0d%0a9606.ENSP00000272298%0d%0a
Selected Interacting proteins: Q9H095-IQCG_HUMAN ENSP00000265239 for IQCG Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for IQCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development ISS --
GO:0007288 sperm axoneme assembly ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with IQCG: view

No data available for Pathways by source and SIGNOR curated interactions for IQCG Gene

Transcripts for IQCG Gene

Unigene Clusters for IQCG Gene

IQ motif containing G:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - - - - - -
SP9:
SP10:

ExUns: 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for IQCG Gene

GeneLoc Exon Structure for
IQCG
ECgene alternative splicing isoforms for
IQCG

Expression for IQCG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IQCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQCG Gene

This gene is overexpressed in Testis (x5.5) and Ovary (x5.0).

Protein differential expression in normal tissues from HIPED for IQCG Gene

This gene is overexpressed in Pancreas (61.1) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCG Gene



Protein tissue co-expression partners for IQCG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IQCG Gene:

IQCG

SOURCE GeneReport for Unigene cluster for IQCG Gene:

Hs.591675
genes like me logo Genes that share expression patterns with IQCG: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IQCG Gene

Orthologs for IQCG Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCG 34 35
  • 99.02 (n)
cow
(Bos Taurus)
Mammalia IQCG 34 35
  • 83.22 (n)
dog
(Canis familiaris)
Mammalia IQCG 34 35
  • 81.71 (n)
mouse
(Mus musculus)
Mammalia Iqcg 34 16 35
  • 76.36 (n)
rat
(Rattus norvegicus)
Mammalia Iqcg 34
  • 75.46 (n)
oppossum
(Monodelphis domestica)
Mammalia IQCG 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQCG 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IQCG 34 35
  • 55.08 (n)
lizard
(Anolis carolinensis)
Reptilia IQCG 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqcg 34
  • 57.75 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-222m18.3 34
  • 52.58 (n)
IQCG 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for IQCG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCG Gene

ENSEMBL:
Gene Tree for IQCG (if available)
TreeFam:
Gene Tree for IQCG (if available)

Paralogs for IQCG Gene

No data available for Paralogs for IQCG Gene

Variants for IQCG Gene

Sequence variations from dbSNP and Humsavar for IQCG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs116840807 Pathogenic 197,951,229(+) CTCTT(-/CTT)AAAAT intron-variant, upstream-variant-2KB, cds-indel
rs116840808 Pathogenic 197,951,244(+) AAGGT(A/G)TTTAC intron-variant, upstream-variant-2KB, reference, missense
rs116840809 Pathogenic 197,954,142(+) GAATC(C/T)GAGTG intron-variant, reference, stop-gained
rs10022 -- 197,955,787(-) TTATT(A/G/T)ATTTT intron-variant, utr-variant-3-prime
rs10686235 -- 197,922,714(+) AAATA(-/AATA)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCG Gene

Variant ID Type Subtype PubMed ID
nsv999711 CNV gain 25217958
nsv979915 CNV duplication 23825009
nsv956289 CNV deletion 24416366
nsv829832 CNV loss 17160897
nsv527527 CNV gain 19592680
nsv238027 CNV deletion 16902084
nsv1161021 CNV duplication 26073780
nsv1144061 CNV deletion 24896259
nsv1126666 CNV deletion 24896259
nsv1073711 CNV deletion 25765185
nsv1013844 CNV gain 25217958
nsv1009299 CNV gain 25217958
esv3893855 CNV gain 25118596
esv3599331 CNV gain 21293372
esv3599330 CNV loss 21293372
esv3599329 CNV gain 21293372
esv3599328 CNV gain 21293372
esv3599324 CNV gain 21293372
esv3599319 CNV gain 21293372
esv3575648 CNV gain 25503493
esv3378719 CNV duplication 20981092
esv2763718 CNV gain+loss 21179565
esv2751989 CNV gain 17911159
esv2671250 CNV deletion 23128226
esv2670685 CNV deletion 23128226
esv2660910 CNV deletion 23128226
esv2408312 CNV deletion 18987734
esv1943012 CNV deletion 18987734
dgv8865n54 CNV gain 21841781
dgv5045n100 CNV gain 25217958
dgv5044n100 CNV gain 25217958

Variation tolerance for IQCG Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.77; 91.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCG Gene

Disorders for IQCG Gene

Relevant External Links for IQCG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCG

No disorders were found for IQCG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCG Gene

Publications for IQCG Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. (PMID: 24362311) Harris T.P. … Schimenti J.C. (G3 (Bethesda) 2014) 2 3 64
  3. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. (PMID: 24787902) Chen L.T. … Chen S.J. (Nat. Commun. 2014) 3 4 64
  4. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R. … Porter M.E. (Mol. Biol. Cell 2013) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for IQCG Gene

Sources for IQCG Gene

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