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IQCG Gene

protein-coding   GIFtS: 47
GCID: GC03M197615

IQ Motif Containing G

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IQ Motif Containing G1 2
IQ Domain-Containing Protein G2

External Ids:    HGNC: 252511   Entrez Gene: 842232   Ensembl: ENSG000001144737   OMIM: 6124775   UniProtKB: Q9H0953   

Export aliases for IQCG gene to outside databases

Previous GC identifers: GC03M199105 GC03M194918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IQCG Gene:
IQCG (IQ motif containing G) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IQCG gene promoter:
         AREB6   AhR   MEF-2A   aMEF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCG promoter sequence
   Search Chromatin IP Primers for IQCG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQCG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

IQCG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M197615:  view genomic region     (about GC identifiers)

Start:
197,615,946 bp from pter      End:
197,687,013 bp from pter
Size:
71,068 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IQCG_HUMAN, Q9H095 (See protein sequence)
Recommended Name: IQ domain-containing protein G  
Size: 443 amino acids; 51918 Da
Secondary accessions: Q9BST2 Q9HAG8
Alternative splicing: 2 isoforms:  Q9H095-1   Q9H095-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCG: NX_Q9H095

Explore proteomics data for IQCG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IQCG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127907.1  NP_115639.1  

    ENSEMBL proteins: 
     ENSP00000265239   ENSP00000407736   ENSP00000389897   ENSP00000406411   ENSP00000393743  

    IQCG Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for IQCG

     
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    antibodies-online proteins for IQCG (4 products) 

     
    antibodies-online peptides for IQCG

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    antibodies-online antibodies for IQCG (12 products) 

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    Cloud-Clone Corp. CLIAs for IQCG
    Search eBioscience for ELISAs for IQCG 
    antibodies-online kits for IQCG (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q9H095

    ProtoNet protein and cluster: Q9H095

    UniProtKB/Swiss-Prot: IQCG_HUMAN, Q9H095
    Similarity: Contains 1 IQ domain


    Find genes that share domains with IQCG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IQCG           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IQCG

    miRNA
    Products:
        
    miRTarBase miRNAs that target IQCG:
    hsa-mir-181a-5p (MIRT025135), hsa-mir-148b-3p (MIRT019420)

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    Search for qRT-PCR Assays for microRNAs that regulate IQCG
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    Predesigned siRNA for gene silencing in human, mouse, rat IQCG

    Gene Editing
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    OriGene ORF clones in mouse, rat for IQCG
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    GenScript: all cDNA clones in your preferred vector (see all 2): IQCG (NM_032263)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IQCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCG

    Cell Line
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    ESI BIO PureStem Progenitor for IQCG: 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with IQCG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IQCG
    Interactions:

        Search GeneGlobe Interaction Network for IQCG

    Selected Interacting proteins for IQCG (Q9H0952, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257350 I2D: score=2 
    BAG6P463793I2D: score=3 
    ENSG00000096155P463793I2D: score=3 
    ENSG00000227761P463793I2D: score=3 
    ENSG00000228760P463793I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IQCG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IQCG gene (2 alternative transcripts): 
    NM_001134435.2  NM_032263.3  

    Unigene Cluster for IQCG:

    IQ motif containing G
    Hs.591675  [show with all ESTs]
    Unigene Representative Sequence: AK095094
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265239(uc003fyp.3) ENST00000455191(uc003fyo.3) ENST00000478903
    ENST00000490748(uc003fyn.3) ENST00000485787 ENST00000469822 ENST00000473225
    ENST00000453254(uc003fyq.4) ENST00000416896 ENST00000480302 ENST00000463651
    ENST00000452735 ENST00000493624
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IQCG
    Clone
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    OriGene clones in human, mouse for IQCG (see all 11)
    OriGene ORF clones in mouse, rat for IQCG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IQCG (NM_032263)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IQCG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCG
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IQCG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IQCG
      QuantiTect SYBR Green Assays in human, mouse, rat IQCG
      QuantiFast Probe-based Assays in human, mouse, rat IQCG

    Additional mRNA sequence: 

    AK021729.1 AK027224.1 AK095094.1 AK096574.1 AL136889.1 BC004816.1 BC016156.1 BC068973.1 
    BC136253.1 CR533515.1 

    12 DOTS entries:

    DT.309217  DT.87017877  DT.97802270  DT.91750441  DT.95196576  DT.101979640  DT.95370440  DT.91750440 
    DT.100811240  DT.100741891  DT.95370439  DT.120919030 

    Selected AceView cDNA sequences (see all 123):

    AW880394 AI564338 AW450885 AI914033 AU117778 AL041282 CR533515 AK021729 
    BG211682 CR611369 BX439227 AI564330 AA043561 NM_032263 BQ267461 AI859303 
    BM908080 AI190567 BM718323 BC068973 AL136889 W74751 AV708221 BE256850 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IQCG (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ·
    SP1:                                -     -     -     -                 -     -                                         -                                       
    SP2:                                                                    -     -                                         -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                                    -     -                                                                                 
    SP5:        -     -                 -     -     -     -                 -     -                                                                                 

    ExUns: 15c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for IQCG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IQCG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACCAATA
    IQCG Expression
    About this image


    IQCG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    IQCG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IQCG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591675
        Custom PCR Arrays for IQCG
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IQCG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcg1 , 5 IQ motif containing G1, 5 76.36(n)1
    67.67(a)1
      16 (23.55 cM)5
    697071  NM_178378.31  NP_848465.11 
     330153855 
    chicken
    (Gallus gallus)
    Aves IQCG1 IQ motif containing G 55.08(n)
    41.67(a)
      424923  XM_422733.4  XP_422733.2 
    lizard
    (Anolis carolinensis)
    Reptilia IQCG6
    IQ motif containing G
    41(a)
    1 ↔ 1
    GL343433.1(430937-455279)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia iqcg1 IQ motif containing G 57.75(n)
    49.3(a)
      100379856  XM_002937345.2  XP_002937391.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-222m18.31 si:ch211-222m18.3 52.58(n)
    39.43(a)
      100322600  XM_005159175.1  XP_005159232.1 


    ENSEMBL Gene Tree for IQCG (if available)
    TreeFam Gene Tree for IQCG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IQCG (see all 1739)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471240841,2
    --194922748(+) AAAAA-/TAGGGG 2 -- int10--------
    rs2002675971,2
    --194933472(+) ATATA-/TATAT 
            
    TTTTT
    2 -- int10--------
    rs1996508931,2
    C--194933475(+) TATAT-/ATTTTT 2 -- int10--------
    rs1477501841,2
    C--194970414(+) CACTG-/GTTT/TCGAT
    TAATTTAGGGTTT
    TCATT
    4 -- int1 cds10--------
    rs717013291,2
    C--194970919(+) TTCCT-/TTCT  
            
    TCTTT
    2 -- int10--------
    rs1889468161,2
    --197472137(+) CCAACA/GTTTAT 2 -- ut310--------
    rs1450605641,2
    C--197472138(+) CAACAA/TTTATT 2 -- ut310--------
    rs1387880521,2
    C--197472202(+) TTCCTA/GCTGAA 2 -- ut310--------
    rs1810512201,2
    --197472295(+) AATGCA/GTCACT 2 -- ut310--------
    rs745931771,2
    C,F--197472376(+) AGAAAC/GTTCTT 2 -- ut311Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for IQCG (197615946 - 197687013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IQCG (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2408312CNV Deletion18987734
    esv2660910CNV Deletion23128226
    esv1943012CNV Deletion18987734
    esv2670685CNV Deletion23128226
    esv2671250CNV Deletion23128226
    nsv238027CNV Loss16902084
    nsv878215CNV Loss21882294
    nsv829832CNV Loss17160897
    nsv527527CNV Gain19592680
    nsv878212CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IQCG
    DNA2.0 Custom Variant and Variant Library Synthesis for IQCG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612477    OMIM disorders: --


    Find genes that share disorders with IQCG           About GenesLikeMe


    Export disorders for IQCG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IQCG gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IQCG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84223 HGNC: 25251 AceView: DKFZp434B227 Ensembl:ENSG00000114473 euGenes: HUgn84223
    ECgene: IQCG H-InvDB: IQCG

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IQCG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IQCG gene:
    Search GeneIP for patents involving IQCG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     PureStem Progenitor for IQCG: PureStem ES-210, Ecto-ntu Progenitor
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