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Aliases for IQCG Gene

Aliases for IQCG Gene

  • IQ Motif Containing G 2 3
  • Dynein Regulatory Complex Subunit 9 2 3
  • CFAP122 3
  • DRC9 3

External Ids for IQCG Gene

Previous GeneCards Identifiers for IQCG Gene

  • GC03M199105
  • GC03M197615
  • GC03M194918

Summaries for IQCG Gene

GeneCards Summary for IQCG Gene

IQCG (IQ Motif Containing G) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCG Gene

Genomics for IQCG Gene

Regulatory Elements for IQCG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IQCG Gene

Chromosome:
3
Start:
197,887,208 bp from pter
End:
197,960,142 bp from pter
Size:
72,935 bases
Orientation:
Minus strand

Genomic View for IQCG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IQCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCG Gene

Proteins for IQCG Gene

  • Protein details for IQCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H095-IQCG_HUMAN
    Recommended name:
    IQ domain-containing protein G
    Protein Accession:
    Q9H095
    Secondary Accessions:
    • Q9BST2
    • Q9HAG8

    Protein attributes for IQCG Gene

    Size:
    443 amino acids
    Molecular mass:
    51918 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IQCG Gene

    Alternative splice isoforms for IQCG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCG Gene

Proteomics data for IQCG Gene at MOPED

Post-translational modifications for IQCG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQCG Gene

No data available for DME Specific Peptides for IQCG Gene

Domains & Families for IQCG Gene

Gene Families for IQCG Gene

Protein Domains for IQCG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCG Gene

Graphical View of Domain Structure for InterPro Entry

Q9H095

UniProtKB/Swiss-Prot:

IQCG_HUMAN :
  • Contains 1 IQ domain.
Domain:
  • Contains 1 IQ domain.
genes like me logo Genes that share domains with IQCG: view

Function for IQCG Gene

Gene Ontology (GO) - Molecular Function for IQCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IQCG: view

Phenotypes for IQCG Gene

GenomeRNAi human phenotypes for IQCG:
genes like me logo Genes that share phenotypes with IQCG: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQCG

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCG Gene

Localization for IQCG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IQCG Gene COMPARTMENTS Subcellular localization image for IQCG gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for IQCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with IQCG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IQCG Gene

Pathways & Interactions for IQCG Gene

SuperPathways for IQCG Gene

No Data Available

Interacting Proteins for IQCG Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000265239%0d%0a9606.ENSP00000272298%0d%0a
Selected Interacting proteins: Q9H095-IQCG_HUMAN ENSP00000265239 for IQCG Gene via I2D MINT STRING

Gene Ontology (GO) - Biological Process for IQCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with IQCG: view

No data available for Pathways by source and SIGNOR curated interactions for IQCG Gene

Drugs & Compounds for IQCG Gene

No Compound Related Data Available

Transcripts for IQCG Gene

Unigene Clusters for IQCG Gene

IQ motif containing G:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQCG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - - - - - -
SP9:
SP10:

ExUns: 15c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for IQCG Gene

GeneLoc Exon Structure for
IQCG
ECgene alternative splicing isoforms for
IQCG

Expression for IQCG Gene

mRNA expression in normal human tissues for IQCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQCG Gene

This gene is overexpressed in Testis (x5.5) and Ovary (x5.0).

Protein differential expression in normal tissues from HIPED for IQCG Gene

This gene is overexpressed in Pancreas (61.1) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCG Gene



SOURCE GeneReport for Unigene cluster for IQCG Gene Hs.591675

genes like me logo Genes that share expression patterns with IQCG: view

Protein tissue co-expression partners for IQCG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IQCG Gene

Orthologs for IQCG Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IQCG 35
  • 83.22 (n)
  • 74.71 (a)
IQCG 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IQCG 35
  • 81.71 (n)
  • 72.44 (a)
IQCG 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iqcg 35
  • 76.36 (n)
  • 67.67 (a)
Iqcg 16
Iqcg 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IQCG 35
  • 99.02 (n)
  • 98.65 (a)
IQCG 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iqcg 35
  • 75.46 (n)
  • 65.08 (a)
oppossum
(Monodelphis domestica)
Mammalia IQCG 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IQCG 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IQCG 35
  • 55.08 (n)
  • 41.67 (a)
IQCG 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQCG 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iqcg 35
  • 57.75 (n)
  • 49.3 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-222m18.3 35
  • 52.58 (n)
  • 39.43 (a)
IQCG 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for IQCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCG Gene

ENSEMBL:
Gene Tree for IQCG (if available)
TreeFam:
Gene Tree for IQCG (if available)

Paralogs for IQCG Gene

No data available for Paralogs for IQCG Gene

Variants for IQCG Gene

Sequence variations from dbSNP and Humsavar for IQCG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1129747 -- 197,956,541(+) ATTGC(A/C)CTTTA intron-variant
rs1157464 -- 197,939,485(+) CGCAG(A/G)AACGG intron-variant
rs1987215 -- 197,902,853(-) ttttg(G/T)ggttc intron-variant
rs3749254 -- 197,912,956(+) CGAGA(C/G)GAGCA intron-variant, nc-transcript-variant
rs3749255 -- 197,944,156(-) ACGAC(A/G)ATGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IQCG Gene

Variant ID Type Subtype PubMed ID
nsv829832 CNV Loss 17160897
esv2751989 CNV Gain 17911159
nsv878208 CNV Gain 21882294
nsv878211 CNV Gain 21882294
nsv527527 CNV Gain 19592680
nsv878212 CNV Gain 21882294
esv2660910 CNV Deletion 23128226
dgv5379n71 CNV Gain 21882294
esv1943012 CNV Deletion 18987734
esv2408312 CNV Deletion 18987734
esv2670685 CNV Deletion 23128226
nsv238027 CNV Loss 16902084
nsv483023 CNV Gain 15286789
esv2671250 CNV Deletion 23128226
nsv878215 CNV Loss 21882294
nsv878216 CNV Gain 21882294

Variation tolerance for IQCG Gene

Residual Variation Intolerance Score: 83.77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.77; 91.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCG Gene

HapMap Linkage Disequilibrium report
IQCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCG Gene

Disorders for IQCG Gene

Relevant External Links for IQCG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCG
genes like me logo Genes that share disorders with IQCG: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCG Gene

Publications for IQCG Gene

  1. IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. (PMID: 24362311) Harris T.P. … Schimenti J.C. (G3 (Bethesda) 2014) 2 67
  2. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R. … Porter M.E. (Mol. Biol. Cell 2013) 2 67
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 67

Products for IQCG Gene

Sources for IQCG Gene

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