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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCF6 Gene

protein-coding   GIFtS: 33
GCID: GC03M051788

IQ Motif Containing F6

  Search for IQCF6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IQ Motif Containing F61 2
IQ Domain-Containing Protein F62

External Ids:    HGNC: 351581   Entrez Gene: 4409562   Ensembl: ENSG000002146867   UniProtKB: A8MYZ53   

Export aliases for IQCF6 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IQCF6 Gene: 
IQCF6 (IQ motif containing F6) is a protein-coding gene. An important paralog of this gene is IQCF5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCF6 gene promoter:
         MZF-1   NF-1   Pax-5   AML1a   HSF2   STAT3   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IQCF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

IQCF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCF6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M051788:  view genomic region     (about GC identifiers)

Start:
51,812,577 bp from pter      End:
51,813,203 bp from pter
Size:
627 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IQCF6_HUMAN, A8MYZ5 (See protein sequence)
Recommended Name: IQ domain-containing protein F6  
Size: 130 amino acids; 15798 Da
Caution: It is uncertain whether Met-1 or Met-24 is the initiator

Explore the universe of human proteins at neXtProt for IQCF6: NX_A8MYZ5

Explore proteomics data for IQCF6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MYZ5

  • IQCF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IQCF6 Protein Expression
    REFSEQ proteins: NP_001137305.2  
    ENSEMBL proteins: 
     ENSP00000381760  

    Human Recombinant Protein Products for IQCF6: 
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    Cloud-Clone Corp. CLIAs for IQCF6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry A8MYZ5

    ProtoNet protein and cluster: A8MYZ5

    UniProtKB/Swiss-Prot: IQCF6_HUMAN, A8MYZ5
    Similarity: Contains 2 IQ domains


    IQCF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IQCF6 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCF6

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCF6

    Search CenterWatch for drugs/clinical trials and news about IQCF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for IQCF6 gene: 
    NM_001143833.3  

    Unigene Cluster for IQCF6:

    IQ motif containing F6
    Hs.444316  [show with all ESTs]
    Unigene Representative Sequence: BX093815
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000398780(uc011bdv.2)
    miRNA
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    1 DOTS entry:

    DT.304687 

    6 AceView cDNA sequences:

    AW590129 BX093815 AA923232 BF510293 AA759071 AA907708 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGCCAAAC
    IQCF6 Expression
    About this image


    See IQCF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCF6

    SOURCE GeneReport for Unigene cluster: Hs.444316
        SABiosciences Custom PCR Arrays for IQCF6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IQCF6 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcf61 , 5 IQ motif containing F61, 5 86.92(n)1
    82.24(a)1
      9 (57.93 cM)5
    1000410961  NM_001101628.11  NP_001095098.11 
     1066265825 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    21(a)
    1 → many
    2(152787985-152805880)


    ENSEMBL Gene Tree for IQCF6 (if available)
    TreeFam Gene Tree for IQCF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQCF6 gene
    IQCF52  IQCF12  IQCF32  IQCF22  
    4 SIMAP similar genes for IQCF6 using alignment to 1 protein entry:     IQCF6_HUMAN:
    IQCF5    IQCF1    IQCF2    IQCF3

    IQCF6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/49 SNPs in IQCF6 are shown (see all 49)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143409421,2
    C,F--51812205(+) CTGCCG/AGCCCT 1 -- int11Minor allele frequency- A:0.13WA 118
    rs1905384741,2
    --51812587(+) GGTCAA/GTAAGG 1 -- ut310--------
    rs1822460021,2
    --51812651(+) ATGAGA/GATTTC 2 I syn10--------
    rs600930281,2
    C,F--51812691(+) CCTCAT/CAGTGG 2 /Y /C mis14Minor allele frequency- C:0.10NS WA EA 318
    rs1851826101,2
    C--51812712(+) GGCCTC/TGGGTT 2 Q R mis10--------
    rs1464998631,2
    C--51812791(+) GCGGGC/TCTGCC 2 T A mis11Minor allele frequency- T:0.00EU 483
    rs2010447121,2
    C--51812865(+) CCAGGA/C/TGCCGT 3 H R L mis11EU 589
    rs765245501,2
    C,F--51812878(+) TTGCTC/TCAACA 2 K E mis11Minor allele frequency- T:0.03EA 120
    rs1399469601,2
    C--51812881(+) CTCCAA/TCATCT 2 M L mis10--------
    rs111302961,2
    C,F,A,H--51812952(+) ACGTCC/TGGCGC 2 Q R mis133Minor allele frequency- T:0.16NS EA NA EU 3817

    HapMap Linkage Disequilibrium report for IQCF6 (51812577 - 51813203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IQCF6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508921CNV Insertion20534489
    nsv520211CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for IQCF6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440956 HGNC: 35158 AceView: LOC440956 Ensembl:ENSG00000214686 euGenes: HUgn440956
    ECgene: IQCF6 H-InvDB: IQCF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQCF6 gene:
    Search GeneIP for patents involving IQCF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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