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Aliases for IQCF3 Gene

Aliases for IQCF3 Gene

  • IQ Motif Containing F3 2 3 5

External Ids for IQCF3 Gene

Previous GeneCards Identifiers for IQCF3 Gene

  • GC03P051826

Summaries for IQCF3 Gene

GeneCards Summary for IQCF3 Gene

IQCF3 (IQ Motif Containing F3) is a Protein Coding gene. An important paralog of this gene is IQCF2.

Additional gene information for IQCF3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCF3 Gene

Genomics for IQCF3 Gene

Regulatory Elements for IQCF3 Gene

Enhancers for IQCF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H051902 0.7 ENCODE 11.1 +85.0 84956 0 ZNF639 SP3 KLF1 INSM2 ZNF223 KLF17 TSHZ1 JUND ZNF629 FOS IQCF5 IQCF5-AS1 RN7SL504P IQCF4 IQCF3 GPR62 PCBP4 IQCF2 IQCF1
GH03H051794 0.2 ENCODE 11.3 -23.2 -23235 0 IQCF3 IQCF4 IQCF5 ABHD14A-ACY1 ABHD14B ABHD14A PCBP4 GC03P051793
GH03H051857 0.2 Ensembl 11.1 +40.0 39997 0 IQCF3 IQCF4 IQCF5-AS1 IQCF2
GH03H051739 0.2 Ensembl 10.8 -78.1 -78104 0 IQCF6 IQCF3 IQCF4 LOC105377087 PIR43233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQCF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IQCF3 Gene

Chromosome:
3
Start:
51,817,604 bp from pter
End:
51,830,858 bp from pter
Size:
13,255 bases
Orientation:
Plus strand

Genomic View for IQCF3 Gene

Genes around IQCF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCF3 Gene

Proteins for IQCF3 Gene

  • Protein details for IQCF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7M6-IQCF3_HUMAN
    Recommended name:
    IQ domain-containing protein F3
    Protein Accession:
    P0C7M6
    Secondary Accessions:
    • B2RUV0

    Protein attributes for IQCF3 Gene

    Size:
    154 amino acids
    Molecular mass:
    18251 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IQCF3 Gene

Post-translational modifications for IQCF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQCF3 Gene

No data available for DME Specific Peptides for IQCF3 Gene

Domains & Families for IQCF3 Gene

Gene Families for IQCF3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IQCF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCF3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCF3: view

No data available for UniProtKB/Swiss-Prot for IQCF3 Gene

Function for IQCF3 Gene

Gene Ontology (GO) - Molecular Function for IQCF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IBA --
genes like me logo Genes that share ontologies with IQCF3: view
genes like me logo Genes that share phenotypes with IQCF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IQCF3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IQCF3 Gene

Localization for IQCF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCF3 gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IQCF3 Gene

Pathways & Interactions for IQCF3 Gene

SuperPathways for IQCF3 Gene

No Data Available

Interacting Proteins for IQCF3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000401767%0d%0a9606.ENSP00000253814%0d%0a
Selected Interacting proteins: P0C7M6-IQCF3_HUMAN ENSP00000401767 for IQCF3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for IQCF3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCF3 Gene

Drugs & Compounds for IQCF3 Gene

No Compound Related Data Available

Transcripts for IQCF3 Gene

Unigene Clusters for IQCF3 Gene

IQ motif containing F3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IQCF3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IQCF3 Gene

No ASD Table

Relevant External Links for IQCF3 Gene

GeneLoc Exon Structure for
IQCF3
ECgene alternative splicing isoforms for
IQCF3

Expression for IQCF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCF3 Gene

mRNA differential expression in normal tissues according to GTEx for IQCF3 Gene

This gene is overexpressed in Testis (x51.5).

Protein differential expression in normal tissues from HIPED for IQCF3 Gene

This gene is overexpressed in Thyroid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCF3 Gene



Protein tissue co-expression partners for IQCF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of IQCF3 Gene:

IQCF3

SOURCE GeneReport for Unigene cluster for IQCF3 Gene:

Hs.729443

Evidence on tissue expression from TISSUES for IQCF3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with IQCF3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCF3 Gene

Orthologs for IQCF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCF3 33 34
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia IQCF3 33 34
  • 74.89 (n)
dog
(Canis familiaris)
Mammalia IQCF3 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Iqcf4 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
OneToMany
Species where no ortholog for IQCF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IQCF3 Gene

ENSEMBL:
Gene Tree for IQCF3 (if available)
TreeFam:
Gene Tree for IQCF3 (if available)

Paralogs for IQCF3 Gene

Paralogs for IQCF3 Gene

(4) SIMAP similar genes for IQCF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IQCF3: view

Variants for IQCF3 Gene

Sequence variations from dbSNP and Humsavar for IQCF3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000359119 -- 51,830,773(+) GCCAG(A/G)GTTCC reference, missense
rs1001246076 -- 51,825,201(+) CCAAC(A/G)TGGCG upstream-variant-2KB
rs1001535865 -- 51,831,134(+) GCTTG(G/T)AATCA downstream-variant-500B
rs1001867406 -- 51,825,393(+) ACACA(C/T)ACACA upstream-variant-2KB
rs1002251998 -- 51,830,442(+) TGAAG(C/G)CAGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IQCF3 Gene

Variant ID Type Subtype PubMed ID
nsv1001350 CNV gain 25217958
nsv520211 CNV gain 19592680

Variation tolerance for IQCF3 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCF3 Gene

Disorders for IQCF3 Gene

Relevant External Links for IQCF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCF3

No disorders were found for IQCF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCF3 Gene

Publications for IQCF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for IQCF3 Gene

Sources for IQCF3 Gene

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