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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCF3 Gene

protein-coding   GIFtS: 34
GCID: GC03P051856

IQ Motif Containing F3

  Search for IQCF3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IQ Motif Containing F31 2
IQ Domain-Containing Protein F32

External Ids:    HGNC: 318161   Entrez Gene: 4010672   Ensembl: ENSG000002299727   UniProtKB: P0C7M63   

Export aliases for IQCF3 gene to outside databases

Previous GC identifer: GC03P051826


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IQCF3 Gene: 
IQCF3 (IQ motif containing F3) is a protein-coding gene. An important paralog of this gene is IQCF6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCF3 gene promoter:
         NF-1   NF-1/L   p53   Arnt   NF-AT   AREB6   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IQCF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.31

IQCF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCF3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051856:  view genomic region     (about GC identifiers)

Start:
51,851,620 bp from pter      End:
51,864,876 bp from pter
Size:
13,257 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IQCF3_HUMAN, P0C7M6 (See protein sequence)
Recommended Name: IQ domain-containing protein F3  
Size: 154 amino acids; 18251 Da

Explore the universe of human proteins at neXtProt for IQCF3: NX_P0C7M6

Explore proteomics data for IQCF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C7M6

  • IQCF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IQCF3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001078948.1  NP_001193952.1  

    ENSEMBL proteins: 
     ENSP00000415609   ENSP00000409373   ENSP00000401767   ENSP00000402530   ENSP00000402012  

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    Cloud-Clone Corp. CLIAs for IQCF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry P0C7M6

    ProtoNet protein and cluster: P0C7M6

    UniProtKB/Swiss-Prot: IQCF3_HUMAN, P0C7M6
    Similarity: Contains 1 IQ domain


    IQCF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IQCF3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IQCF3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCF3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCF3

    Search CenterWatch for drugs/clinical trials and news about IQCF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IQCF3 gene (2 alternative transcripts): 
    NM_001085479.2  NM_001207023.1  

    Unigene Cluster for IQCF3:

    IQ motif containing F3
    Hs.729443  [show with all ESTs]
    Unigene Representative Sequence: NM_001085479
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456080(uc021wyy.1 uc021wyz.1) ENST00000437810 ENST00000446775
    ENST00000472485 ENST00000465028 ENST00000474242 ENST00000444293 ENST00000462079
    ENST00000440739
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    Additional mRNA sequence: 

    BC021188.2 BC146874.1 BC146889.1 BC171811.1 BC171818.1 

    2 DOTS entries:

    DT.408459  DT.95260709 

    24/30 AceView cDNA sequences (see all 30):

    AA460144 AA398133 BC021188 AA453974 AA991812 BX643092 BE467881 BI829946 
    AA383334 AA394104 AI024944 AK057432 BX101258 AW449917 AA453469 AI651900 
    AA460742 BE551679 AW592364 AA405042 AI694420 AA992611 AA910466 AW291394 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAACAGGC
    IQCF3 Expression
    About this image


    See IQCF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCF3

    SOURCE GeneReport for Unigene cluster: Hs.729443
        SABiosciences Custom PCR Arrays for IQCF3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IQCF3 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcf35 IQ motif containing F3   --   9 (57.74 cM) 106543389 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    26(a)
    1 → many
    2(152787985-152805880)


    ENSEMBL Gene Tree for IQCF3 (if available)
    TreeFam Gene Tree for IQCF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQCF3 gene
    IQCF62  IQCF52  IQCF12  IQCF22  
    4 SIMAP similar genes for IQCF3 using alignment to 3 protein entries:     IQCF3_HUMAN (see all proteins):
    IQCF6    IQCF2    IQCF5    IQCF1

    IQCF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/139 SNPs in IQCF3 are shown (see all 139)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs608183621,2
    C--51858914(+) TATGTG/TAAAGT 2 -- us2k14Minor allele frequency- T:0.07WA NA EA 360
    rs1921491111,2
    --51858960(+) GCCAAA/GTCAGC 2 -- us2k10--------
    rs1839733491,2
    --51859107(+) GTTAAA/GAACCG 2 -- us2k10--------
    rs1876975401,2
    --51859111(+) AAAACC/TGCACA 2 -- us2k10--------
    rs1913289981,2
    --51859167(+) AGGCCA/GAGGTA 2 -- us2k10--------
    rs1132898881,2
    C,F--51859196(+) AGGAGG/TTCAAG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1462323371,2
    --51859295(+) TACTCA/GGGAGG 2 -- us2k10--------
    rs98771781,2
    C,F--51859300(+) gggagG/Actgag 2 -- us2k12Minor allele frequency- A:0.25NA CSA 4
    rs610114891,2
    C--51859320(+) TCACTC/TGAGCC 2 -- us2k10--------
    rs1837689761,2
    --51859332(+) AGGAGA/GAGGAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for IQCF3 (51851620 - 51864876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IQCF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520211CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQCF3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401067 HGNC: 31816 AceView: IQCF3 Ensembl:ENSG00000229972 euGenes: HUgn401067
    ECgene: IQCF3 H-InvDB: IQCF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQCF3 gene:
    Search GeneIP for patents involving IQCF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCF3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IQCF3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IQCF3
    Customized:
     lentivirus for stable overexpression of IQCF3
     lentivirus expression plasmids for stable overexpression of IQCF3
     adenovirus for overexpression of IQCF3
     Search LSBio for Antibodies for IQCF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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