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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCF1 Gene

protein-coding   GIFtS: 42
GCID: GC03M051928

IQ Motif Containing F1

  Search for IQCF1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IQ Motif Containing F11 2
IQ Domain-Containing Protein F12

External Ids:    HGNC: 286071   Entrez Gene: 1321412   Ensembl: ENSG000001733897   UniProtKB: Q8N6M83   

Export aliases for IQCF1 gene to outside databases

Previous GC identifers: GC03M051818 GC03M051903 GC03M051843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IQCF1 Gene: 
IQCF1 (IQ motif containing F1) is a protein-coding gene. An important paralog of this gene is IQCF6.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCF1 gene promoter:
         c-Fos   AP-1   Bach2   JunB   Fra-1   FosB   MyoD   POU2F2C   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IQCF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.31

IQCF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M051928:  view genomic region     (about GC identifiers)

Start:
51,928,892 bp from pter      End:
51,937,386 bp from pter
Size:
8,495 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IQCF1_HUMAN, Q8N6M8 (See protein sequence)
Recommended Name: IQ domain-containing protein F1  
Size: 205 amino acids; 23699 Da
Secondary accessions: Q8N711
Alternative splicing: 2 isoforms:  Q8N6M8-1   Q8N6M8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCF1: NX_Q8N6M8

Explore proteomics data for IQCF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N6M8

  • IQCF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IQCF1 Protein Expression
    REFSEQ proteins: NP_689610.2  
    ENSEMBL proteins: 
     ENSP00000307958   ENSP00000317715  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q8N6M8

    ProtoNet protein and cluster: Q8N6M8

    UniProtKB/Swiss-Prot: IQCF1_HUMAN, Q8N6M8
    Similarity: Contains 2 IQ domains


    IQCF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IQCF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IQCF1:
     Decreased TP53 protein express  Decreased cell number, increas 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCF1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCF1

    Search CenterWatch for drugs/clinical trials and news about IQCF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for IQCF1 gene: 
    NM_152397.2  

    Unigene Cluster for IQCF1:

    IQ motif containing F1
    Hs.671210  [show with all ESTs]
    Unigene Representative Sequence: BC034228
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310914(uc003dbq.4 uc003dbv.3) ENST00000314534
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    Additional mRNA sequence: 

    AK131018.1 BC029595.1 BC034228.1 

    3 DOTS entries:

    DT.40265443  DT.95185004  DT.97785108 

    12 AceView cDNA sequences:

    AI825444 AW004079 BM560164 AW593295 AK131018 AA861580 BC029595 NM_152397 
    BC034228 BI551525 BI548459 BI459409 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IQCF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                
    SP2:              -                                 
    SP3:                                                


    ECgene alternative splicing isoforms for IQCF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTTCACT
    IQCF1 Expression
    About this image


    See IQCF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCF1

    SOURCE GeneReport for Unigene cluster: Hs.671210
        SABiosciences Custom PCR Arrays for IQCF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IQCF1 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcf11 , 5 IQ motif containing F11, 5 74.49(n)1
    62.57(a)1
      9 (57.65 cM)5
    742671  NM_028843.11  NP_083119.11 
     1064999675 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    29(a)
    1 → many
    2(152787985-152805880)


    ENSEMBL Gene Tree for IQCF1 (if available)
    TreeFam Gene Tree for IQCF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQCF1 gene
    IQCF62  IQCF52  IQCF32  IQCF22  
    4 SIMAP similar genes for IQCF1 using alignment to 2 protein entries:     IQCF1_HUMAN (see all proteins):
    IQCF6    IQCF2    IQCF5    IQCF3

    IQCF1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IQCF1
    PGOHUM00000239429


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 SNPs in IQCF1 are shown (see all 246)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400310751,2
    --51928492(+) TTGGGC/GTTGGG 1 -- int10--------
    rs1869874391,2
    --51928512(+) TCAGTC/TCTAGG 1 -- int10--------
    rs1995913991,2
    C--51928538(-) AGTTGA/CTCAGG 1 -- int10--------
    rs1917326421,2
    --51928553(+) CCAGAA/CGAGTG 1 -- int10--------
    rs1841861191,2
    --51928614(+) CCATTA/GTACCA 1 -- int10--------
    rs1452286571,2
    --51928616(+) ATTATA/GCCAAG 1 -- int10--------
    rs1476248801,2
    --51928693(+) AATTGA/GCTGGT 1 -- int10--------
    rs1890296001,2
    --51928757(+) CTGCTC/TAGTCT 1 -- int10--------
    rs1451526691,2
    C,F--51928908(+) ACTTCA/GTTCCT 2 R * stop-lost1Minor allele frequency- G:0.00NA 4548
    rs1422547531,2
    C--51928928(+) AGGGAA/GTACAC 2 T I mis10--------

    HapMap Linkage Disequilibrium report for IQCF1 (51928892 - 51937386 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IQCF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520211CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQCF1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132141 HGNC: 28607 AceView: IQCF1 Ensembl:ENSG00000173389 euGenes: HUgn132141
    ECgene: IQCF1 H-InvDB: IQCF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQCF1 gene:
    Search GeneIP for patents involving IQCF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for IQCF1
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     Browse ProSpec Recombinant Proteins




     Proteins for IQCF1
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCF1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IQCF1
     SwitchGear Promoter luciferase reporter plasmids for IQCF1
     Search ThermoFisher Antibodies for IQCF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IQCF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IQCF1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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