Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IQCE Gene

Aliases for IQCE Gene

  • IQ Motif Containing E 2 3 5
  • 1700028P05Rik 3
  • KIAA1023 4

External Ids for IQCE Gene

Previous GeneCards Identifiers for IQCE Gene

  • GC07P002371
  • GC07P002565
  • GC07P002598

Summaries for IQCE Gene

GeneCards Summary for IQCE Gene

IQCE (IQ Motif Containing E) is a Protein Coding gene. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR.

Gene Wiki entry for IQCE Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCE Gene

Genomics for IQCE Gene

Regulatory Elements for IQCE Gene

Enhancers for IQCE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IQCE on UCSC Golden Path with GeneCards custom track

Promoters for IQCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IQCE on UCSC Golden Path with GeneCards custom track

Genomic Location for IQCE Gene

2,558,972 bp from pter
2,614,734 bp from pter
55,763 bases
Plus strand

Genomic View for IQCE Gene

Genes around IQCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCE Gene

Proteins for IQCE Gene

  • Protein details for IQCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ domain-containing protein E
    Protein Accession:
    Secondary Accessions:
    • Q4G0P7
    • Q6P7T4
    • Q9H0H7
    • Q9UPX7

    Protein attributes for IQCE Gene

    695 amino acids
    Molecular mass:
    77298 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA82975.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCE Gene


neXtProt entry for IQCE Gene

Proteomics data for IQCE Gene at MOPED

Post-translational modifications for IQCE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IQCE Gene

Domains & Families for IQCE Gene

Protein Domains for IQCE Gene


Suggested Antigen Peptide Sequences for IQCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 IQ domains.
  • Contains 2 IQ domains.
genes like me logo Genes that share domains with IQCE: view

No data available for Gene Families for IQCE Gene

Function for IQCE Gene

genes like me logo Genes that share phenotypes with IQCE: view

Animal Models for IQCE Gene

MGI Knock Outs for IQCE:
  • Iqce tm1b(EUCOMM)Hmgu

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IQCE Gene

Localization for IQCE Gene

Subcellular locations from

Jensen Localization Image for IQCE Gene COMPARTMENTS Subcellular localization image for IQCE gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCE Gene

Pathways & Interactions for IQCE Gene

genes like me logo Genes that share pathways with IQCE: view

Pathways by source for IQCE Gene

Gene Ontology (GO) - Biological Process for IQCE Gene


No data available for SIGNOR curated interactions for IQCE Gene

Drugs & Compounds for IQCE Gene

No Compound Related Data Available

Transcripts for IQCE Gene

Unigene Clusters for IQCE Gene

IQ motif containing E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IQCE Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: -
SP8: -
SP9: - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b
SP1: - - -
SP2: -
SP3: - - -
SP6: -

Relevant External Links for IQCE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCE Gene

mRNA expression in normal human tissues for IQCE Gene

Protein differential expression in normal tissues from HIPED for IQCE Gene

This gene is overexpressed in Nasal epithelium (31.7), Serum (9.7), Urine (9.3), Platelet (7.2), and Bone marrow mesenchymal stem cell (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCE Gene

SOURCE GeneReport for Unigene cluster for IQCE Gene Hs.520627

genes like me logo Genes that share expression patterns with IQCE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IQCE Gene

Orthologs for IQCE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCE Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IQCE 35
  • 75.19 (n)
  • 68.42 (a)
  • 67 (a)
(Canis familiaris)
Mammalia IQCE 35
  • 76.29 (n)
  • 70.95 (a)
  • 72 (a)
(Mus musculus)
Mammalia Iqce 35
  • 74.15 (n)
  • 67.48 (a)
Iqce 16
Iqce 36
  • 58 (a)
(Pan troglodytes)
Mammalia IQCE 35
  • 99.18 (n)
  • 98.42 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Iqce 35
  • 74.1 (n)
  • 66.72 (a)
(Monodelphis domestica)
Mammalia IQCE 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia IQCE 36
  • 44 (a)
(Gallus gallus)
Aves IQCE 35
  • 58.49 (n)
  • 48.63 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia IQCE 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqce 35
  • 53.85 (n)
  • 45.48 (a)
(Danio rerio)
Actinopterygii iqce 35
  • 49.79 (n)
  • 41.12 (a)
iqce 36
  • 33 (a)
Species with no ortholog for IQCE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCE Gene

Gene Tree for IQCE (if available)
Gene Tree for IQCE (if available)

Paralogs for IQCE Gene

No data available for Paralogs for IQCE Gene

Variants for IQCE Gene

Sequence variations from dbSNP and Humsavar for IQCE Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11976972 - 2,572,233(+) GGGAG(A/C)ATGCG intron-variant, reference, missense
rs2293404 - 2,604,885(+) GGCGG(C/T)TGTGG reference, missense
rs10950797 - 2,605,892(+) GCCCC(A/G)CGTTC reference, missense
rs2293407 - 2,605,918(+) AGGCC(A/G)CGGGC reference, missense
rs3735109 - 2,610,070(+) AGGCC(A/G/T)TGGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IQCE Gene

Variant ID Type Subtype PubMed ID
dgv7116n71 CNV Loss 21882294
dgv7117n71 CNV Loss 21882294
dgv7118n71 CNV Loss 21882294
dgv7119n71 CNV Loss 21882294
nsv830887 CNV Loss 17160897
nsv887297 CNV Loss 21882294
nsv887298 CNV Loss 21882294
esv1553581 CNV Deletion 17803354
esv2733858 CNV Deletion 23290073
nsv887300 CNV Loss 21882294
esv2349098 CNV Deletion 18987734
nsv471227 CNV Loss 18288195
esv994621 CNV Insertion 20482838
esv1234995 CNV Insertion 17803354
esv2733859 CNV Deletion 23290073
esv2357458 CNV Deletion 18987734
esv2733860 CNV Deletion 23290073
esv2733862 CNV Deletion 23290073
esv1223273 CNV Deletion 17803354
nsv887301 CNV Loss 21882294
dgv401n21 CNV Loss 19592680
dgv7121n71 CNV Loss 21882294
nsv823982 CNV Gain 20364138
nsv887303 CNV Loss 21882294
dgv7122n71 CNV Loss 21882294

Variation tolerance for IQCE Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.31; 94.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCE Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCE Gene

Disorders for IQCE Gene

Relevant External Links for IQCE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IQCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCE Gene

Publications for IQCE Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for IQCE Gene

Sources for IQCE Gene