IQCE Gene
protein-coding GIFtS: 48
GCID: GC07P002598
|
|
IQ motif containing E
| |
Aliases
for IQCE gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IQ Motif Containing E1 2 | | KIAA10231 3 | | 1700028P05Rik2 | | IQ Domain-Containing Protein E2 |
Export aliases for IQCE gene to outside databasesPrevious GC identifers: GC07P002371 GC07P002565 |
Summaries
for IQCE gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for IQCE
|
Genomic Views
for IQCE gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IQCE gene promoter:
GR Elk-1 p53 AP-4 E47 HEN1 AREB6 ZIC2/Zic2 GR-alpha Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for IQCE
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCE |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3IQCE Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P002598: view genomic region
(about GC identifiers)
Start:
|
2,598,632 bp from pter |
End:
|
2,654,368 bp from pter |
Size:
|
55,737 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 2,646,544-2,702,212 |
|
Proteins
for IQCE gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IQCE_HUMAN, Q6IPM2 (See
protein sequence)Recommended Name: IQ domain-containing protein E Size: 695 amino acids; 77298 Da
Sequence caution: Sequence=BAA82975.2; Type=Erroneous initiation;
Secondary accessions: Q4G0P7 Q6P7T4 Q9H0H7 Q9UPX7Alternative splicing: 4 isoforms: Q6IPM2-1 Q6IPM2-2 Q6IPM2-3 Q6IPM2-4 Explore the universe of human proteins at neXtProt for IQCE: NX_Q6IPM2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IPM2
IQCE Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001093860.1 NP_689771.3
ENSEMBL proteins: ENSP00000385597 ENSP00000404643 ENSP00000396178 ENSP00000314011 ENSP00000313772 ENSP00000413570 ENSP00000402108 ENSP00000415261 ENSP00000405982 ENSP00000385945
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
IQCE for ontologies About GeneDecksing
IQCE Antibody Products:
Assay Products for IQCE: |
Protein
Domains /
Families
for IQCE gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IQCE for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6IPM2ProtoNet protein and cluster: Q6IPM2 UniProtKB/Swiss-Prot: IQCE_HUMAN, Q6IPM2Similarity: Contains 2 IQ domains |
Function
for IQCE gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IQCE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IQCE (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): IQCE (NM_152558) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQCE | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCE |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCE |
|
Pathways & Interactions
for IQCE gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCE
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for IQCE (Q6IPM23 ENSP000003855974) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for IQCE gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IQCE
Search CenterWatch for drugs/clinical trials and news about IQCE
|
Transcripts
for IQCE gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IQCE gene (2 alternative transcripts): NM_001100390.1 NM_152558.3 Unigene Cluster for IQCE: IQ motif containing E Hs.520627 [show with all ESTs]Unigene Representative Sequence: NM_15255815 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402050(uc003smo.4 uc003smk.4 uc003smn.4) ENST00000415271
ENST00000470731(uc010ksm.1) ENST00000438376 ENST00000325997 ENST00000476665(uc003sml.1 uc011jvy.1 uc011jvz.1)
ENST00000325979 ENST00000423395 ENST00000422276 ENST00000497572 ENST00000427817
ENST00000490913 ENST00000423196 ENST00000486730 ENST00000404984
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IQCE (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IQCE (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IQCE (NM_152558) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQCE | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCE |
Additional cDNA sequence: AK092404.1 AK293372.1 AK302053.1 AK309646.1 AL137525.1 BC043150.1 BC052992.1 BC061518.1 BC071858.1 9 DOTS entries: DT.414779 DT.100698977 DT.97845966 DT.95365850 DT.97845964 DT.434409 DT.95279950 DT.95353626 DT.40122670 24/145 AceView cDNA sequences (see all 145): AI654081 AA313894 BM790638 BC061518 NM_152558 CA413951 AL137525 BM506727 AI766114 BC071858 AL136792 CD244236 BQ711976 BC043150 BM701883 BM811550 CR596730 AW026255 BQ022206 BM968759 BM982506 Z41307 BM810054 BQ953604
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IQCE (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27a | · | 27b |
|---|
|
| SP1: | - | | | | | | | | | | | | - | | - | | | | | | |
| SP2: | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IQCE
|
Expression
for IQCE gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IQCE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCCGAGCC
About this image
See IQCE Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IQCE
SOURCE GeneReport for Unigene cluster: Hs.520627
SABiosciences Custom PCR Arrays for IQCE
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IQCE
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IQCE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IQCE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IQCE | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCE |
Orthologs
for IQCE gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IQCE gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for IQCE (if available)
TreeFam Gene Tree for IQCE (if available) |
Paralogs
for IQCE gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IQCE gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IQCE (2598632 - 2654368 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for IQCE
2 CNVs: 30256 30257
3 Indels: 47328 28611 47327
Human Gene Mutation Database (HGMD): IQCE
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IQCE |
|
Disorders
/ Diseases
for IQCE gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IQCE for disorders About GeneDecksing
1  disease for IQCE: About MalaCardsmicrocephaly
Human Genome Epidemiology (HuGE) Navigator: IQCE (1 document)
Export disorders for IQCE gene to outside databases
|
Publications
for IQCE gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IQCE gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with IQCE) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)
|
External Searches for IQCE gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IQCE gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IQCE gene
(According to HUGE)
About This Section
| |
Specialized Databases showing IQCE gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IQCE | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IQCE gene:
Search GeneIP for patents involving IQCE
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IQCE gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IQCE | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IQCE | | | OriGene Protein Over-expression Lysate for IQCE | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IQCE | | OriGene 3'-UTR Clone for IQCE | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IQCE | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IQCE | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IQCE | | OriGene Custom Protein Services for IQCE | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IQCE | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IQCE | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCE | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IQCE | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IQCE | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IQCE |
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| | | | Search Tocris compounds for IQCE |
| |  |  |  |  | | | | |
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 | | | IQCE Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCE |
|  |  |  | | | | ThermoFisher Antibodies for IQCE |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCE |
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