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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCD Gene

protein-coding   GIFtS: 38
GCID: GC12M113633

IQ motif containing D
  Search for IQCD
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IQCD    

Aliases
for IQCD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
IQ Motif Containing D1 2
4933433C09Rik2
IQ Domain-Containing Protein D2

External Ids:    HGNC: 251681   Entrez Gene: 1158112   Ensembl: ENSG000001665787   UniProtKB: Q96DY23   

Export aliases for IQCD gene to outside databases

Previous GC identifers: GC12M112095 GC12M112117 GC12M110645


Summaries
for IQCD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IQCD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCD gene promoter:
         MyoD   LUN-1   E47   MEF-2A   PPAR-gamma1   CBF-A   ARP-1   aMEF-2   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IQCD promoter sequence
   Search SABiosciences Chromatin IP Primers for IQCD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.13   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.21

IQCD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCD gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M113633:  view genomic region     (about GC identifiers)

Start:
 113,633,246 bp from pter      End:
 113,658,899 bp from pter
Size:
 25,654 bases      Orientation:
 minus strand

Proteins
for IQCD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IQCD_HUMAN, Q96DY2 (See protein sequence)
Recommended Name: IQ domain-containing protein D  
Size: 449 amino acids; 52359 Da
Secondary accessions: Q6ZSU0
Alternative splicing: 3 isoforms:  Q96DY2-1   Q96DY2-2   Q96DY2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCD: NX_Q96DY2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96DY2

    • IQCD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_612460.1  
    ENSEMBL proteins: 
     ENSP00000299732   ENSP00000400669   ENSP00000446623  

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    Protein Domains /
    Families
    for IQCD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IQCD for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q96DY2

    ProtoNet protein and cluster: Q96DY2

    UniProtKB/Swiss-Prot: IQCD_HUMAN, Q96DY2
    Similarity: Contains 1 IQ domain


    Function
    for IQCD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for IQCD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCD

    5 Interacting proteins for IQCD (Q96DY23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3833I2D: score=1 
    LUC7L2Q9Y3833I2D: score=1 
    ATG4BQ9Y4P13I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    SQSTM1Q135013I2D: score=1 
    About this table

    Drugs & Compounds
    for IQCD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCD
    Search CenterWatch for drugs/clinical trials and news about IQCD 

    Transcripts
    for IQCD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IQCD gene: 
    NM_138451.1  

    Unigene Cluster for IQCD:

    IQ motif containing D
    Hs.568276  [show with all ESTs]
    Unigene Representative Sequence: AK127152
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299732(uc001tuu.3) ENST00000416617 ENST00000546692

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK127152.1 BC013151.1 

    4 DOTS entries:

    DT.95364715  DT.101975356  DT.86838828  DT.100715438 

    19 AceView cDNA sequences:

    BC013151 AI638678 BI759487 NM_138451 BX460555 CR598947 BI767185 BX455121 
    CD358970 BI819363 BI546833 AK127152 BG106655 BF589655 AW291216 BE560347 
    CD636422 CD636421 BX409773 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IQCD    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                                                                    -               
    SP2:                    -                                                               
    SP3:                    -                       -     -     -     -     -     -         
    SP4:                                                                                    
    SP5:                                            -     -                                 


    ECgene alternative splicing isoforms for IQCD

    Expression
    for IQCD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTTATTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IQCD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IQCD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCD

    SOURCE GeneReport for Unigene cluster: Hs.568276
        SABiosciences Custom PCR Arrays for IQCD
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCD

    Orthologs
    for IQCD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IQCD gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Iqcd5 IQ motif containing D   --   5 (60.63 cM) 120589016 
    chicken
    (Gallus gallus)    		 Aves IQCD6
    		 Uncharacterized protein
    		 27(a)
    		 1 ↔ 1
    		 15(11102118-11107808)
    lizard
    (Anolis carolinensis)    		 Reptilia IQCD6
    		 --
    		 25(a)
    		 1 ↔ 1
    		 GL343338.1(814140-818294)
    zebrafish
    (Danio rerio)    		 Actinopterygii iqcd6
    		 IQ motif containing D
    		 25(a)
    		 1 ↔ 1
    		 5(24865002-24869815)


    ENSEMBL Gene Tree for IQCD (if available)
    TreeFam Gene Tree for IQCD (if available) 

    Paralogs
    for IQCD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQCD gene
    IQCG2  

    IQCD for paralogs           About GeneDecksing



    Genomic Variants
    for IQCD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/377 NCBI SNPs in IQCD are shown (see all 377)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38423051,2
    		C,--113632809(-) TTTTTT/-AAAGT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1851749971,2
    		--113632828(+) TGTTTC/TAAATA 1 -- int10--------
    rs714658881,2
    		C,F,--113632968(+) AAACCG/TGAGGC 1 -- int13Minor allele frequency- T:0.50NA 6
    rs1909142841,2
    		--113633035(+) CCACAC/TCCCGC 1 -- int10--------
    rs128280941,2
    		C,F,H,--113633039(+) ACCCCG/ACTGCC 1 -- int19Minor allele frequency- A:0.03NS EA NA 680
    rs594093301,2
    		C,--113633312(+) GTGCTC/TTCCAT 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1831741481,2
    		--113633366(+) AGCGGG/TCTGGG 1 -- ut310--------
    rs1179696231,2
    		C,F,--113633445(+) TTTGCC/TCTTGC 2 S G mis11Minor allele frequency- T:0.00NA 4552
    rs1494764661,2
    		F--113633515(+) ATGAGC/TGTGGC 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs1456513091,2
    		C,--113633532(+) TACCAT/CGCGCA 2 /M /V mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for IQCD (113633246 - 113658899 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IQCD: --

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    Disorders / Diseases
    for IQCD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for IQCD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQCD gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for IQCD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IQCD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115811 HGNC: 25168 AceView: IQCD Ensembl:ENSG00000166578 euGenes: HUgn115811
    ECgene: IQCD H-InvDB: IQCD

    Other Databases showing IQCD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IQCD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IQCD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IQCD gene:
    Search GeneIP for patents involving IQCD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IQCD gene

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    About This Section

     
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    von Willebrand factor
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