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Aliases for IQCC Gene

Aliases for IQCC Gene

  • IQ Motif Containing C 2 3 5

External Ids for IQCC Gene

Previous GeneCards Identifiers for IQCC Gene

  • GC01P032340
  • GC01P032443
  • GC01P032671
  • GC01P030787

Summaries for IQCC Gene

GeneCards Summary for IQCC Gene

IQCC (IQ Motif Containing C) is a Protein Coding gene.

Additional gene information for IQCC Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCC Gene

Genomics for IQCC Gene

GeneHancer (GH) Regulatory Elements for IQCC Gene

Promoters and enhancers for IQCC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I032204 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 145 2 HDGF MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 SP5 ZNF592 IQCC PIR35641 ENSG00000224066 SNRNP40 TSSK3 TXLNA KPNA6 AK2 LOC105378626 CCDC28B
GH01I032271 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 29.7 +67.9 67915 5.1 ZNF493 ZNF133 GLI4 ETS1 ZNF121 GLIS2 SP3 YY2 NCOA1 SMARCA4 LCK RBBP4 ZBTB8A TXLNA KHDRBS1 IQCC SNRNP40 S100PBP ZBTB8B ENSG00000224066
GH01I032178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.3 -25.3 -25290 4.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B TXLNA ENSG00000224066 IQCC DCDC2B SNRNP40 TSSK3 KPNA6 RBBP4 TMEM234 EIF3I
GH01I031951 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -249.6 -249565 9.1 DMAP1 YBX1 IRF4 YY1 E2F8 ZC3H11A MEF2D GLIS1 RCOR2 NBN SNRNP40 KHDRBS1 TXLNA RBBP4 TSSK3 TMEM39B ENSG00000229447 ZBTB8A IQCC ENSG00000228634
GH01I032262 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +59.8 59753 4.8 ZNF493 ZNF529 ZFP64 RARA ZNF213 SCRT2 ZNF654 ZNF680 ZBTB11 CEBPB TXLNA RBBP4 SNRNP40 KHDRBS1 TSSK3 TMEM39B ZBTB8A ZNF362 DCDC2B S100PBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IQCC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IQCC gene promoter:

Genomic Locations for IQCC Gene

Genomic Locations for IQCC Gene
chr1:32,205,635-32,208,687
(GRCh38/hg38)
Size:
3,053 bases
Orientation:
Plus strand
chr1:32,671,236-32,674,288
(GRCh37/hg19)

Genomic View for IQCC Gene

Genes around IQCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCC Gene

Proteins for IQCC Gene

  • Protein details for IQCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMZ1-IQCC_HUMAN
    Recommended name:
    IQ domain-containing protein C
    Protein Accession:
    Q4KMZ1
    Secondary Accessions:
    • F5H7T8
    • Q4KMS3
    • Q4KMZ5
    • Q53FL2
    • Q5TFJ8
    • Q9NVS3

    Protein attributes for IQCC Gene

    Size:
    466 amino acids
    Molecular mass:
    53032 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK307853; Type=Erroneous termination; Positions=323; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCC Gene

Post-translational modifications for IQCC Gene

Other Protein References for IQCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQCC Gene

Domains & Families for IQCC Gene

Gene Families for IQCC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCC: view

No data available for UniProtKB/Swiss-Prot for IQCC Gene

Function for IQCC Gene

genes like me logo Genes that share phenotypes with IQCC: view

miRNA for IQCC Gene

miRTarBase miRNAs that target IQCC

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCC Gene

Localization for IQCC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCC gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCC Gene

Pathways & Interactions for IQCC Gene

No Data Available

Interacting Proteins for IQCC Gene

Selected Interacting proteins: Q4KMZ1-IQCC_HUMAN for IQCC Gene via UniProtKB

Symbol External ID(s) Details
CCHCR1

Gene Ontology (GO) - Biological Process for IQCC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCC Gene

Drugs & Compounds for IQCC Gene

No Compound Related Data Available

Transcripts for IQCC Gene

mRNA/cDNA for IQCC Gene

Unigene Clusters for IQCC Gene

IQ motif containing C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for IQCC Gene

GeneLoc Exon Structure for
IQCC
ECgene alternative splicing isoforms for
IQCC

Expression for IQCC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCC Gene

mRNA differential expression in normal tissues according to GTEx for IQCC Gene

This gene is overexpressed in Testis (x4.0).

Protein differential expression in normal tissues from HIPED for IQCC Gene

This gene is overexpressed in Breast (54.1) and Lung (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCC Gene



Protein tissue co-expression partners for IQCC Gene

NURSA nuclear receptor signaling pathways regulating expression of IQCC Gene:

IQCC

SOURCE GeneReport for Unigene cluster for IQCC Gene:

Hs.274356
genes like me logo Genes that share expression patterns with IQCC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCC Gene

Orthologs for IQCC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCC 33 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia IQCC 33 34
  • 75.91 (n)
dog
(Canis familiaris)
Mammalia IQCC 33 34
  • 74.44 (n)
mouse
(Mus musculus)
Mammalia Iqcc 33 16 34
  • 72.28 (n)
rat
(Rattus norvegicus)
Mammalia Iqcc 33
  • 68.43 (n)
lizard
(Anolis carolinensis)
Reptilia IQCC 34
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii iqcc 34
  • 22 (a)
OneToOne
Species where no ortholog for IQCC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCC Gene

ENSEMBL:
Gene Tree for IQCC (if available)
TreeFam:
Gene Tree for IQCC (if available)

Paralogs for IQCC Gene

No data available for Paralogs for IQCC Gene

Variants for IQCC Gene

Sequence variations from dbSNP and Humsavar for IQCC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs41263993 risk-factor, Bardet-Biedl syndrome 1, modifier of 32,204,044(+) C/T upstream_transcript_variant
rs199647520 uncertain-significance, not specified 32,204,190(+) G/A upstream_transcript_variant
rs200163249 uncertain-significance, not specified 32,203,995(+) G/A/T upstream_transcript_variant
rs140234450 benign, not specified 32,204,317(+) G/A upstream_transcript_variant
rs1000383939 -- 32,204,373(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IQCC Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for IQCC Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IQCC Gene

Human Gene Mutation Database (HGMD)
IQCC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCC Gene

Disorders for IQCC Gene

Additional Disease Information for IQCC

No disorders were found for IQCC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCC Gene

Publications for IQCC Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for IQCC Gene

Sources for IQCC Gene

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