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Aliases for IQCC Gene

Aliases for IQCC Gene

  • IQ Motif Containing C 2 3 5

External Ids for IQCC Gene

Previous GeneCards Identifiers for IQCC Gene

  • GC01P032340
  • GC01P032443
  • GC01P032671
  • GC01P030787

Summaries for IQCC Gene

GeneCards Summary for IQCC Gene

IQCC (IQ Motif Containing C) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCC Gene

Genomics for IQCC Gene

Regulatory Elements for IQCC Gene

Enhancers for IQCC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G031951 2.1 FANTOM5 Ensembl ENCODE dbSUPER 28.5 -249.6 -249565 9.1 CREB3L1 DMAP1 YBX1 YY1 TBX21 MEF2D GLIS1 RCOR2 NBN NR2C1 IQCC ENSG00000224066 SNRNP40 KHDRBS1 ENSG00000235790 LOC105378626 DCDC2B MTMR9LP PTP4A2 TMEM234
GH01G032897 0.9 dbSUPER 37.5 +693.0 693002 1.6 ZNF133 ZSCAN4 ZNF493 ZFP64 FEZF1 RAD21 ZNF335 ZNF302 SCRT2 ZNF416 IQCC ENSG00000224066 ZBTB8B DCDC2B KPNA6 MTMR9LP TMEM54 S100PBP GC01P032892
GH01G032132 1.3 Ensembl ENCODE 22.3 -72.2 -72225 2.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS ZNF548 KLF13 SNRNP40 KPNA6 EIF3I ENSG00000229447 IQCC TSSK3 CCDC28B ENSG00000224066 DCDC2B TMEM234
GH01G031711 2 FANTOM5 Ensembl ENCODE dbSUPER 13 -491.8 -491829 4.8 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ADGRB2 ENSG00000224066 SNRNP40 DCDC2B TSSK3 IQCC PEF1 ENSG00000235790 KPNA6 EIF3I
GH01G032988 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +785.6 785644 6.6 HDGF PKNOX1 ARNT ZFP64 SIN3A YBX1 ZNF766 FOS KLF13 DEK RNF19B ZBTB8B EIF3I DCDC2B ENSG00000239670 KPNA6 TSSK3 AK2 AZIN2 MTMR9LP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQCC on UCSC Golden Path with GeneCards custom track

Promoters for IQCC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004329 65 1001 HDGF MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 PAF1 SP5

Genomic Location for IQCC Gene

Chromosome:
1
Start:
32,205,635 bp from pter
End:
32,208,687 bp from pter
Size:
3,053 bases
Orientation:
Plus strand

Genomic View for IQCC Gene

Genes around IQCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCC Gene

Proteins for IQCC Gene

  • Protein details for IQCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMZ1-IQCC_HUMAN
    Recommended name:
    IQ domain-containing protein C
    Protein Accession:
    Q4KMZ1
    Secondary Accessions:
    • F5H7T8
    • Q4KMS3
    • Q4KMZ5
    • Q53FL2
    • Q5TFJ8
    • Q9NVS3

    Protein attributes for IQCC Gene

    Size:
    466 amino acids
    Molecular mass:
    53032 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK307853; Type=Erroneous termination; Positions=323; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCC Gene

Post-translational modifications for IQCC Gene

  • Ubiquitination at isoforms=2, 3127
  • Modification sites at PhosphoSitePlus

Other Protein References for IQCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQCC Gene

Domains & Families for IQCC Gene

Protein Domains for IQCC Gene

Suggested Antigen Peptide Sequences for IQCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IQCC Gene

Function for IQCC Gene

genes like me logo Genes that share phenotypes with IQCC: view

Animal Model Products

CRISPR Products

miRNA for IQCC Gene

miRTarBase miRNAs that target IQCC

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCC Gene

Localization for IQCC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCC gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCC Gene

Pathways & Interactions for IQCC Gene

No Data Available

Interacting Proteins for IQCC Gene

Gene Ontology (GO) - Biological Process for IQCC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCC Gene

Drugs & Compounds for IQCC Gene

No Compound Related Data Available

Transcripts for IQCC Gene

mRNA/cDNA for IQCC Gene

Unigene Clusters for IQCC Gene

IQ motif containing C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for IQCC Gene

GeneLoc Exon Structure for
IQCC
ECgene alternative splicing isoforms for
IQCC

Expression for IQCC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCC Gene

mRNA differential expression in normal tissues according to GTEx for IQCC Gene

This gene is overexpressed in Testis (x4.0).

Protein differential expression in normal tissues from HIPED for IQCC Gene

This gene is overexpressed in Breast (54.1) and Lung (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCC Gene



Protein tissue co-expression partners for IQCC Gene

NURSA nuclear receptor signaling pathways regulating expression of IQCC Gene:

IQCC

SOURCE GeneReport for Unigene cluster for IQCC Gene:

Hs.274356
genes like me logo Genes that share expression patterns with IQCC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCC Gene

Orthologs for IQCC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCC 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia IQCC 34 35
  • 75.91 (n)
dog
(Canis familiaris)
Mammalia IQCC 34 35
  • 74.44 (n)
mouse
(Mus musculus)
Mammalia Iqcc 34 16 35
  • 72.28 (n)
rat
(Rattus norvegicus)
Mammalia Iqcc 34
  • 68.43 (n)
lizard
(Anolis carolinensis)
Reptilia IQCC 35
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii iqcc 35
  • 22 (a)
OneToOne
Species where no ortholog for IQCC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCC Gene

ENSEMBL:
Gene Tree for IQCC (if available)
TreeFam:
Gene Tree for IQCC (if available)

Paralogs for IQCC Gene

No data available for Paralogs for IQCC Gene

Variants for IQCC Gene

Sequence variations from dbSNP and Humsavar for IQCC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs199647520 Uncertain significance 32,204,190(+) GGGAA(A/G)GAATG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs200163249 Uncertain significance 32,203,995(+) GGGGG(A/G/T)ACTCC upstream-variant-2KB, reference, missense
rs140234450 Benign 32,204,317(+) CTGAG(A/G)GGCTG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs41263993 other 32,204,044(+) GCCTT(C/T)GGTGA upstream-variant-2KB, reference, synonymous-codon
rs1000383939 -- 32,204,373(+) CTGCT(A/T)AGCAA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IQCC Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for IQCC Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCC Gene

Disorders for IQCC Gene

Relevant External Links for IQCC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCC

No disorders were found for IQCC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCC Gene

Publications for IQCC Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for IQCC Gene

Sources for IQCC Gene

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