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IQCC Gene

protein-coding   GIFtS: 45
GCID: GC01P032671

IQ Motif Containing C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IQ Motif Containing C1 2
IQ Domain-Containing Protein C2

External Ids:    HGNC: 255451   Entrez Gene: 557212   Ensembl: ENSG000001600517   UniProtKB: Q4KMZ13   

Export aliases for IQCC gene to outside databases

Previous GC identifers: GC01P032340 GC01P032443 GC01P030787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IQCC Gene:
IQCC (IQ motif containing C) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the IQCC gene promoter:
         Pax-3   NF-1   POU2F1   POU2F1a   STAT3   HSF1short   HSF1 (long)   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCC promoter sequence
   Search Chromatin IP Primers for IQCC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11-p34.2   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p36.11-p34.2

IQCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032671:  view genomic region     (about GC identifiers)

Start:
32,671,236 bp from pter      End:
32,674,288 bp from pter
Size:
3,053 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IQCC_HUMAN, Q4KMZ1 (See protein sequence)
Recommended Name: IQ domain-containing protein C  
Size: 466 amino acids; 53032 Da
Sequence caution: Sequence=AK307853; Type=Erroneous termination; Positions=323; Note=Translated as Gln;
Secondary accessions: F5H7T8 Q4KMS3 Q4KMZ5 Q53FL2 Q5TFJ8 Q9NVS3
Alternative splicing: 3 isoforms:  Q4KMZ1-1   Q4KMZ1-2   Q4KMZ1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCC: NX_Q4KMZ1

Explore proteomics data for IQCC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127
  • Modification sites at PhosphoSitePlus

  • See IQCC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153514.1  NP_060604.2  

    ENSEMBL proteins: 
     ENSP00000291358   ENSP00000442291  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q4KMZ1

    ProtoNet protein and cluster: Q4KMZ1

    UniProtKB/Swiss-Prot: IQCC_HUMAN, Q4KMZ1
    Similarity: Contains 1 IQ domain


    Find genes that share domains with IQCC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IQCC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IQCC:
     Synthetic lethal with c-Myc af 

    Animal Models:
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    4 qRT-PCR Assays for microRNAs that regulate IQCC:
    hsa-miR-942 hsa-miR-361-3p hsa-miR-766 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIQCC 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IQCC
    Interactions:

        Search GeneGlobe Interaction Network for IQCC

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IQCC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IQCC gene (2 alternative transcripts): 
    NM_001160042.1  NM_018134.2  

    Unigene Cluster for IQCC:

    IQ motif containing C
    Hs.274356  [show with all ESTs]
    Unigene Representative Sequence: NM_001160042
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291358 ENST00000537469(uc001bum.2 uc009vua.2 uc010ogz.1)

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    hsa-miR-942 hsa-miR-361-3p hsa-miR-766 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIQCC 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001409.1 AK223272.1 AK299235.1 AK307853.1 BC029986.1 BC098250.1 BC098260.1 BC098317.1 
    BC098366.1 

    5 DOTS entries:

    DT.423309  DT.121395563  DT.97804796  DT.100657045  DT.95088175 

    20 AceView cDNA sequences:

    AA299636 BX281334 BF970007 BX348178 AA299637 AI002609 BF476009 NM_018134 
    AU127716 BG248100 BX374559 BM020291 CD654945 AA188423 BF982159 AK001409 
    CF134802 AA188725 AU150200 BP344128 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IQCC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:              -           -                 -               
    SP2:              -           -                                 
    SP3:                          -                                 
    SP4:              -                                             


    ECgene alternative splicing isoforms for IQCC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IQCC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAATGAA
    IQCC Expression
    About this image

    IQCC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IQCC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274356
        Custom PCR Arrays for IQCC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IQCC gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcc1 , 5 IQ motif containing C1, 5 72.28(n)1
    56.19(a)1
      4 (63.26 cM)5
    2307671  NM_198026.21  NP_932143.21 
     1296151265 
    lizard
    (Anolis carolinensis)
    Reptilia IQCC6
    IQ motif containing C
    35(a)
    1 ↔ 1
    GL343706.1(128127-131023)
    zebrafish
    (Danio rerio)
    Actinopterygii iqcc6
    IQ motif containing C
    22(a)
    1 ↔ 1
    13(33521940-33525588) ENSDARG00000092483


    ENSEMBL Gene Tree for IQCC (if available)
    TreeFam Gene Tree for IQCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IQCC (see all 49)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164962011,2
    C,F--32671564(+) CTTAAG/CGCGAG 3 /N /K int1 mis11Minor allele frequency- C:0.07WA 118
    rs1912870891,2
    --32671572(+) GAGGAA/GGGGCA 2 -- int10--------
    rs1822041231,2
    --32671639(+) CCTTTC/TCCCGC 2 -- int10--------
    rs1179718281,2
    C--32671720(+) CCGTGA/GTAAGG 2 -- int11Minor allele frequency- G:0.01EA 120
    rs2021122741,2
    C--32671722(+) GTGATA/GAGGGA 2 -- int10--------
    rs1444171421,2
    C,F--32671801(+) CCTGCG/TAGCTG 4 R L mis11Minor allele frequency- T:0.00NA 4532
    rs1930913561,2
    C--32671919(+) GAGAGA/CAGGGA 2 -- int10--------
    rs780029931,2
    --32671957(+) ACCCTA/TCCCAG 2 -- int10--------
    rs761749701,2
    F--32671958(+) CCCTTC/ACCAGT 2 -- int11Minor allele frequency- A:0.01WA 118
    rs2013104731,2
    --32672097(+) ATCTCC/TCTTGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for IQCC (32671236 - 32674288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IQCC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv300CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IQCC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IQCC gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IQCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55721 HGNC: 25545 AceView: IQCC Ensembl:ENSG00000160051 euGenes: HUgn55721
    ECgene: IQCC H-InvDB: IQCC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IQCC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IQCC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IQCC gene:
    Search GeneIP for patents involving IQCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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