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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCC Gene

protein-coding   GIFtS: 43
GCID: GC01P032671

IQ Motif Containing C

  Search for IQCC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IQ Motif Containing C1 2
RP4-622L5.62
IQ Domain-Containing Protein C2

External Ids:    HGNC: 255451   Entrez Gene: 557212   Ensembl: ENSG000001600517   UniProtKB: Q4KMZ13   

Export aliases for IQCC gene to outside databases

Previous GC identifers: GC01P032340 GC01P032443 GC01P030787


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IQCC Gene: 
IQCC (IQ motif containing C) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCC gene promoter:
         Pax-3   NF-1   POU2F1   POU2F1a   STAT3   HSF1short   HSF1 (long)   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCC promoter sequence
   Search SABiosciences Chromatin IP Primers for IQCC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11-p34.2   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p36.11-p34.2

IQCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032671:  view genomic region     (about GC identifiers)

Start:
32,671,236 bp from pter      End:
32,674,288 bp from pter
Size:
3,053 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IQCC_HUMAN, Q4KMZ1 (See protein sequence)
Recommended Name: IQ domain-containing protein C  
Size: 466 amino acids; 53032 Da
Sequence caution: Sequence=AK307853; Type=Erroneous termination; Positions=323; Note=Translated as Gln;
Secondary accessions: F5H7T8 Q4KMS3 Q4KMZ5 Q53FL2 Q5TFJ8 Q9NVS3
Alternative splicing: 3 isoforms:  Q4KMZ1-1   Q4KMZ1-2   Q4KMZ1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCC: NX_Q4KMZ1

Explore proteomics data for IQCC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4KMZ1

  • IQCC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IQCC Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153514.1  NP_060604.2  

    ENSEMBL proteins: 
     ENSP00000291358   ENSP00000442291  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q4KMZ1

    ProtoNet protein and cluster: Q4KMZ1

    UniProtKB/Swiss-Prot: IQCC_HUMAN, Q4KMZ1
    Similarity: Contains 1 IQ domain


    IQCC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IQCC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IQCC:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IQCC 
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    SwitchGear 3'UTR luciferase reporter plasmidIQCC 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCC

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCC

    Search CenterWatch for drugs/clinical trials and news about IQCC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IQCC gene (2 alternative transcripts): 
    NM_001160042.1  NM_018134.2  

    Unigene Cluster for IQCC:

    IQ motif containing C
    Hs.274356  [show with all ESTs]
    Unigene Representative Sequence: NM_001160042
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291358 ENST00000537469(uc001bum.2 uc009vua.2 uc010ogz.1)

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    SwitchGear 3'UTR luciferase reporter plasmidIQCC 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001409.1 AK223272.1 AK299235.1 AK307853.1 BC029986.1 BC098250.1 BC098260.1 BC098317.1 
    BC098366.1 

    5 DOTS entries:

    DT.423309  DT.121395563  DT.97804796  DT.100657045  DT.95088175 

    20 AceView cDNA sequences:

    BF970007 BX281334 AA299636 BX374559 AK001409 AA188423 BG248100 CD654945 
    BF982159 AU127716 BF476009 AA299637 AI002609 BM020291 NM_018134 BX348178 
    CF134802 AA188725 AU150200 BP344128 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IQCC    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
    SP1:              -           -                 -               
    SP2:              -           -                                 
    SP3:                          -                                 
    SP4:              -                                             


    ECgene alternative splicing isoforms for IQCC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAATGAA
    IQCC Expression
    About this image


    See IQCC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCC

    SOURCE GeneReport for Unigene cluster: Hs.274356
        SABiosciences Custom PCR Arrays for IQCC
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IQCC gene from 4/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcc1 , 5 IQ motif containing C1, 5 72.69(n)1
    56.63(a)1
      4 (63.26 cM)5
    2307671  NM_198026.21  NP_932143.21 
     1296151265 
    chicken
    (Gallus gallus)
    Aves IQCC1 IQ motif containing C 54.02(n)
    43.59(a)
      419646  XM_417794.3  XP_417794.2 
    lizard
    (Anolis carolinensis)
    Reptilia IQCC6
    Uncharacterized protein
    32(a)
    1 ↔ 1
    GL343706.1(128127-131023)
    zebrafish
    (Danio rerio)
    Actinopterygii iqcc6
    IQ motif containing C
    24(a)
    1 ↔ 1
    13(33521940-33525588)


    ENSEMBL Gene Tree for IQCC (if available)
    TreeFam Gene Tree for IQCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/49 SNPs in IQCC are shown (see all 49)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0314114
    ----see VAR_0314112 F C mis40--------
    VAR_0314134
    ----see VAR_0314132 P L mis40--------
    VAR_0314124
    ----see VAR_0314122 C Y mis40--------
    rs1164962011,2
    C,F--32671564(+) CTTAAG/CGCGAG 3 /N /K int1 mis11Minor allele frequency- C:0.07WA 118
    rs1912870891,2
    --32671572(+) GAGGAA/GGGGCA 2 -- int10--------
    rs1822041231,2
    --32671639(+) CCTTTC/TCCCGC 2 -- int10--------
    rs1179718281,2
    C--32671720(+) CCGTGA/GTAAGG 2 -- int11Minor allele frequency- G:0.01EA 120
    rs2021122741,2
    C--32671722(+) GTGATA/GAGGGA 2 -- int10--------
    rs1444171421,2
    C,F--32671801(+) CCTGCG/TAGCTG 4 R L mis11Minor allele frequency- T:0.00NA 4532
    rs1930913561,2
    C--32671919(+) GAGAGA/CAGGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for IQCC (32671236 - 32674288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IQCC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv300CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQCC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55721 HGNC: 25545 AceView: IQCC Ensembl:ENSG00000160051 euGenes: HUgn55721
    ECgene: IQCC H-InvDB: IQCC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IQCC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQCC gene:
    Search GeneIP for patents involving IQCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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