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Aliases for IQCC Gene

Aliases for IQCC Gene

  • IQ Motif Containing C 2 3 5

External Ids for IQCC Gene

Previous GeneCards Identifiers for IQCC Gene

  • GC01P032340
  • GC01P032443
  • GC01P032671
  • GC01P030787

Summaries for IQCC Gene

GeneCards Summary for IQCC Gene

IQCC (IQ Motif Containing C) is a Protein Coding gene.

Additional gene information for IQCC Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCC Gene

Genomics for IQCC Gene

Regulatory Elements for IQCC Gene

Enhancers for IQCC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H032271 1.5 Ensembl ENCODE dbSUPER 29.7 +67.9 67915 5 ZNF493 ZNF133 GLI4 ETS1 ZNF121 GLIS2 SP3 YY2 NCOA1 SMARCA4 RBBP4 ZBTB8A TXLNA KHDRBS1 IQCC SNRNP40 S100PBP ZBTB8B ENSG00000224066 ZNF362
GH01H031951 2.1 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -249.6 -249565 9 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YBX1 YY1 ZNF766 SNRNP40 KHDRBS1 RBBP4 TMEM39B TXLNA ZBTB8A IQCC ENSG00000224066 TSSK3 MTMR9LP
GH01H032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +59.8 59753 4 ZNF493 ZFP64 RARA SCRT2 ZNF654 ZNF680 ZC3H11A CEBPB OVOL3 REST TXLNA RBBP4 KHDRBS1 SNRNP40 TMEM39B ZBTB8A ZNF362 DCDC2B TSSK3 S100PBP
GH01H032132 1.3 Ensembl ENCODE 22.3 -72.2 -72225 2 HDGF PKNOX1 ARNT SIN3A ZNF766 CBX5 FOS ZNF548 REST ZNF592 SNRNP40 TXLNA KPNA6 KHDRBS1 ENSG00000229447 IQCC TSSK3 EIF3I CCDC28B AK2
GH01H032178 1.2 ENCODE 22.3 -25.3 -25291 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000224066 IQCC DCDC2B KPNA6 RBBP4 EIF3I TMEM234 HDAC1 S100PBP ZBTB8OS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IQCC on UCSC Golden Path with GeneCards custom track

Promoters for IQCC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004329 65 1001 HDGF MLX ARID4B SIN3A DMAP1 YY1 SP5 SMARCB1 ZNF592 KAT8

Genomic Location for IQCC Gene

Chromosome:
1
Start:
32,205,635 bp from pter
End:
32,208,687 bp from pter
Size:
3,053 bases
Orientation:
Plus strand

Genomic View for IQCC Gene

Genes around IQCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCC Gene

Proteins for IQCC Gene

  • Protein details for IQCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4KMZ1-IQCC_HUMAN
    Recommended name:
    IQ domain-containing protein C
    Protein Accession:
    Q4KMZ1
    Secondary Accessions:
    • F5H7T8
    • Q4KMS3
    • Q4KMZ5
    • Q53FL2
    • Q5TFJ8
    • Q9NVS3

    Protein attributes for IQCC Gene

    Size:
    466 amino acids
    Molecular mass:
    53032 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK307853; Type=Erroneous termination; Positions=323; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IQCC Gene

Post-translational modifications for IQCC Gene

  • Ubiquitination at posLast=127127
  • Modification sites at PhosphoSitePlus

Other Protein References for IQCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IQCC Gene

Domains & Families for IQCC Gene

Gene Families for IQCC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IQCC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IQCC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IQCC: view

No data available for UniProtKB/Swiss-Prot for IQCC Gene

Function for IQCC Gene

genes like me logo Genes that share phenotypes with IQCC: view

Animal Model Products

CRISPR Products

miRNA for IQCC Gene

miRTarBase miRNAs that target IQCC

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IQCC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCC Gene

Localization for IQCC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IQCC gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCC Gene

Pathways & Interactions for IQCC Gene

No Data Available

Interacting Proteins for IQCC Gene

Selected Interacting proteins: Q4KMZ1-IQCC_HUMAN for IQCC Gene via UniProtKB

Symbol External ID(s) Details
CCHCR1

Gene Ontology (GO) - Biological Process for IQCC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IQCC Gene

Drugs & Compounds for IQCC Gene

No Compound Related Data Available

Transcripts for IQCC Gene

mRNA/cDNA for IQCC Gene

Unigene Clusters for IQCC Gene

IQ motif containing C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IQCC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IQCC Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for IQCC Gene

GeneLoc Exon Structure for
IQCC
ECgene alternative splicing isoforms for
IQCC

Expression for IQCC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IQCC Gene

mRNA differential expression in normal tissues according to GTEx for IQCC Gene

This gene is overexpressed in Testis (x4.0).

Protein differential expression in normal tissues from HIPED for IQCC Gene

This gene is overexpressed in Breast (54.1) and Lung (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IQCC Gene



Protein tissue co-expression partners for IQCC Gene

NURSA nuclear receptor signaling pathways regulating expression of IQCC Gene:

IQCC

SOURCE GeneReport for Unigene cluster for IQCC Gene:

Hs.274356
genes like me logo Genes that share expression patterns with IQCC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IQCC Gene

Orthologs for IQCC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IQCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQCC 33 34
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia IQCC 33 34
  • 75.91 (n)
dog
(Canis familiaris)
Mammalia IQCC 33 34
  • 74.44 (n)
mouse
(Mus musculus)
Mammalia Iqcc 33 16 34
  • 72.28 (n)
rat
(Rattus norvegicus)
Mammalia Iqcc 33
  • 68.43 (n)
lizard
(Anolis carolinensis)
Reptilia IQCC 34
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii iqcc 34
  • 22 (a)
OneToOne
Species where no ortholog for IQCC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCC Gene

ENSEMBL:
Gene Tree for IQCC (if available)
TreeFam:
Gene Tree for IQCC (if available)

Paralogs for IQCC Gene

No data available for Paralogs for IQCC Gene

Variants for IQCC Gene

Sequence variations from dbSNP and Humsavar for IQCC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs199647520 Uncertain significance 32,204,190(+) GGGAA(A/G)GAATG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs200163249 Uncertain significance 32,203,995(+) GGGGG(A/G/T)ACTCC upstream-variant-2KB, reference, missense
rs140234450 Benign 32,204,317(+) CTGAG(A/G)GGCTG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs41263993 other 32,204,044(+) GCCTT(C/T)GGTGA upstream-variant-2KB, reference, synonymous-codon
rs1000383939 -- 32,204,373(+) CTGCT(A/T)AGCAA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IQCC Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for IQCC Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IQCC Gene

Human Gene Mutation Database (HGMD)
IQCC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IQCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCC Gene

Disorders for IQCC Gene

Relevant External Links for IQCC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IQCC

No disorders were found for IQCC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCC Gene

Publications for IQCC Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60

Products for IQCC Gene

Sources for IQCC Gene

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