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IQCB1 Gene

protein-coding   GIFtS: 56
GCID: GC03M121488

IQ Motif Containing B1

(Previous name: IQ calmodulin-binding motif containing 1)
  See IQCB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IQ Motif Containing B11 2     nephrocystin-51
NPHP52 3 5     SLSN52
IQ Calmodulin-Binding Motif Containing 11 2     IQ Calmodulin-Binding Motif-Containing Protein 12
PIQ2 3     Nephrocystin 52
P53 And DNA Damage-Regulated IQ Motif Protein2 3     Nephrocystin-53
KIAA00363 5     

External Ids:    HGNC: 289491   Entrez Gene: 96572   Ensembl: ENSG000001732267   OMIM: 6092375   UniProtKB: Q150513   

Export aliases for IQCB1 gene to outside databases

Previous GC identifers: GC03M122810 GC03M122971 GC03M118862


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IQCB1 Gene:
This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase
regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It
is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The
protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type
5. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2009)

GeneCards Summary for IQCB1 Gene:
IQCB1 (IQ motif containing B1) is a protein-coding gene. Diseases associated with IQCB1 include senior-loken syndrome 5, and iqcb1-related leber congenital amaurosis. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot: IQCB1_HUMAN, Q15051
Function: Involved in ciliogenesis (By similarity)

Gene Wiki entry for IQCB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IQCB1 gene promoter:
         p53   CUTL1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCB1 promoter sequence
   Search Chromatin IP Primers for IQCB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IQCB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33|3q21.1   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q21.1

IQCB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M121488:  view genomic region     (about GC identifiers)

Start:
121,488,610 bp from pter      End:
121,553,926 bp from pter
Size:
65,317 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IQCB1_HUMAN, Q15051 (See protein sequence)
Recommended Name: IQ calmodulin-binding motif-containing protein 1  
Size: 598 amino acids; 68929 Da
Subunit: Interacts with calmodulin. Interacts with CEP290. Interacts with ATXN10. Interacts with NPHP1, INVS,
NPHP4 and RPGRIP1L; these interactions likely require additional interactors
Sequence caution: Sequence=BAA04968.2; Type=Erroneous initiation;
Secondary accessions: Q3KS08 Q3KS09 Q5DKQ7 Q8NI79 Q9BS08
Alternative splicing: 3 isoforms:  Q15051-1   Q15051-2   Q15051-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IQCB1: NX_Q15051

Explore proteomics data for IQCB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys205
  • Modification sites at PhosphoSitePlus

  • See IQCB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018864.2  NP_001018865.2  

    ENSEMBL proteins: 
     ENSP00000311505   ENSP00000323756   ENSP00000377261   ENSP00000419168   ENSP00000417832  
     ENSP00000419376  

    IQCB1 Human Recombinant Protein Products:

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    Novus Biologicals IQCB1 Proteins
    Novus Biologicals IQCB1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for IQCB1 (4 products) 

     
    antibodies-online peptides for IQCB1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR028765 IQCB1
     IPR027417 P-loop_NTPase
     IPR000048 IQ_motif_EF-hand-BS
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q15051

    ProtoNet protein and cluster: Q15051

    1 Blocks protein domain: IPB000048 IQ calmodulin-binding region

    UniProtKB/Swiss-Prot: IQCB1_HUMAN, Q15051
    Similarity: Contains 4 IQ domains


    Find genes that share domains with IQCB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IQCB1_HUMAN, Q15051
    Function: Involved in ciliogenesis (By similarity)
    Induction: Down-regulated by DNA damage in a p53-dependent manner

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding IDA15723066
         
    Find genes that share ontologies with IQCB1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IQCB1

    miRNA
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    miRTarBase miRNAs that target IQCB1:
    hsa-mir-24-3p (MIRT030516), hsa-mir-98-5p (MIRT027674), hsa-mir-10a-5p (MIRT047676)

    Block miRNA regulation of human, mouse, rat IQCB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IQCB1 (see all 12):
    hsa-miR-98 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-570 hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIQCB1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IQCB1_HUMAN, Q15051: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localization to the
    centrosome depends on the interaction with CEP290
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with IQCB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including IQCB1: 
              Primary Cilia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IQCB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IQCB1 (Q150512, 3 ENSP000003115054) via UniProtKB, MINT, STRING, and/or I2D (see all 213)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM3P621582, 3MINT-8200205 I2D: score=4 
    CALM1P621582, 3, ENSP000003494674MINT-8200205 I2D: score=4 STRING: ENSP00000349467
    CALM2P621582, 3, ENSP000002722984MINT-8200205 I2D: score=4 STRING: ENSP00000272298
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    IRAK2O431873, ENSP000002564584I2D: score=1 STRING: ENSP00000256458
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly ISS--
    GO:0045494photoreceptor cell maintenance IMP15723066
    GO:0048496maintenance of organ identity IMP15723066

    Find genes that share ontologies with IQCB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IQCB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IQCB1 gene (2 alternative transcripts): 
    NM_001023570.2  NM_001023571.2  

    Unigene Cluster for IQCB1:

    IQ motif containing B1
    Hs.604110  [show with all ESTs]
    Unigene Representative Sequence: NM_001023570
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310864(uc010hre.1 uc003eek.2 uc010hrf.1) ENST00000349820
    ENST00000393650 ENST00000460108 ENST00000498104 ENST00000462442 ENST00000471726

    miRNA
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    Block miRNA regulation of human, mouse, rat IQCB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IQCB1 (see all 12):
    hsa-miR-98 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-let-7i hsa-miR-570 hsa-let-7e hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidIQCB1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IQCB1
    Predesigned siRNA for gene silencing in human, mouse, rat IQCB1
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      QuantiTect SYBR Green Assays in human, mouse, rat IQCB1
      QuantiFast Probe-based Assays in human, mouse, rat IQCB1

    Additional mRNA sequence: 

    AB062481.1 AY714228.1 AY964667.1 AY964668.1 BC005806.2 D25278.1 

    14 DOTS entries:

    DT.318017  DT.91760722  DT.95171945  DT.97844664  DT.91760731  DT.120891667  DT.120891678  DT.95171948 
    DT.100795251  DT.121304407  DT.121621887  DT.304458  DT.65288707  DT.86849037 

    Selected AceView cDNA sequences (see all 131):

    CR603196 BQ431109 BM760730 BX110902 AI287587 T27697 BM903549 BX341475 
    AA281303 AA291160 BQ049645 AW051735 BM682018 BM922027 BC005806 AB062481 
    BG108485 AA878157 CD106658 BI822549 BX385543 CA430867 D25278 BI766752 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IQCB1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d
    SP1:              -                                                                                                         
    SP2:              -                                   -     -     -                                                         
    SP3:                                                              -                                                         
    SP4:                                                                                            -                           
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for IQCB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IQCB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGTGTTT
    IQCB1 Expression
    About this image

    IQCB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IQCB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.604110

    UniProtKB/Swiss-Prot: IQCB1_HUMAN, Q15051
    Tissue specificity: Ubiquitously expressed in fetal and adult tissues. Localized to the outer segments and
    connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including IQCB1: 
              Primary Cilia in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IQCB1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqcb11 , 5 IQ calmodulin-binding motif containing 11, 5 88.74(n)1
    86.96(a)1
      16 (26.11 cM)5
    3202991  NM_177128.41  NP_796102.21 
     368283855 
    chicken
    (Gallus gallus)
    Aves IQCB11 IQ motif containing B1 64.12(n)
    56.54(a)
      424242  XM_422091.4  XP_422091.4 
    lizard
    (Anolis carolinensis)
    Reptilia IQCB16
    IQ motif containing B1
    52(a)
    1 ↔ 1
    1(83813647-83836047)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX773835.12   -- 68.27(n)    BX773835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iqcb11 IQ motif containing B1 50.37(n)
    38.5(a)
      494079  NM_001008622.1  NP_001008622.1 


    ENSEMBL Gene Tree for IQCB1 (if available)
    TreeFam Gene Tree for IQCB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IQCB1 gene

    Find genes that share paralogs with IQCB1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for IQCB1
    PGOHUM00000237739 PGOHUM00000243536


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IQCB1 (see all 1301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219182441,2
    Cpathogenic1121467663(-) AGAAAC/TGAGTG 4 R * stg11Minor allele frequency- T:0.00EU 1323
    rs113089891,2
    C--118878803(+) TACTG-/AAAAAA 2 -- int1 trp31Minor allele frequency- A:0.50CSA 2
    rs1478995961,2
    C--118880635(+) GTCTC-/A/AA  
            
    AAAAA
    2 -- int10--------
    rs769057501,2
    C--118883671(+) AAAAAT/AAAATA 2 -- int12Minor allele frequency- A:0.25NA WA 4
    rs1470063501,2
    C--118896386(+) CAAAT-/TCTCTGTG 2 -- cds10--------
    rs724594321,2
    C--118898259(+) TCAAA-/GCAAA 
            
    TATTC
    2 -- int10--------
    rs1379582131,2
    C--118899690(+) GACAG-/ACACAGC 2 -- int10--------
    rs3774333791,2
    --118899692(+) CAGAC-/ATAGCAG 2 -- int10--------
    rs58522781,2
    C--118900225(+) CTGAT-/AAAAAA 2 -- int1 trp30--------
    rs1431564861,2
    C--118916116(+) AGTAA-/AACACAAC 2 -- cds10--------

    HapMap Linkage Disequilibrium report for IQCB1 (121488610 - 121553926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IQCB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2447293CNV Deletion19546169
    nsv877383CNV Loss21882294
    esv33139CNV Loss17666407
    nsv829703CNV Loss17160897
    nsv516233CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): IQCB1
    Locus Specific Mutation Databases (LSDB): IQCB1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609237   
    OMIM disorders: 609254  
    UniProtKB/Swiss-Prot: IQCB1_HUMAN, Q15051
  • Senior-Loken syndrome 5 (SLSN5) [MIM:609254]: A renal-retinal disorder characterized by progressive
    wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease,
    and progressive eye disease. Typically this disorder becomes apparent during the first year of life. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 9 diseases for IQCB1:    
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    senior-loken syndrome 5    iqcb1-related leber congenital amaurosis    verbal auditory agnosia    auditory agnosia
    retinitis pigmentosa 3    senior-loken syndrome    senior-loken syndrome 1    leber congenital amaurosis 17
    leber congenital amaurosis

    7 diseases from the University of Copenhagen DISEASES database for IQCB1:
    Nephronophthisis     Verbal auditory agnosia     Seckel syndrome     Cystic kidney
    Retinitis pigmentosa     Leber congenital amaurosis     Situs inversus

    Find genes that share disorders with IQCB1           About GenesLikeMe

    Genetic Association Database (GAD): IQCB1
    Human Genome Epidemiology (HuGE) Navigator: IQCB1 (2 documents)

    Export disorders for IQCB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IQCB1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with IQCB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior- Loken syndrome and interacts with RPGR and calmodulin. (PubMed id 15723066)1, 2, 3, 9 Otto E.A.... Hildebrandt F. (Nat. Genet. 2005)
    2. Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers. (PubMed id 16322217)1, 2, 9 Luo X.... Sheikh M.S. (Cancer Res. 2005)
    3. Variations in NPHP5 in patients with nonsyndromic leber congenital amaurosis and Senior-Loken syndrome. (PubMed id 21220633)1, 4 Stone E.M....Jacobson S.G. (Arch. Ophthalmol. 2011)
    4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1, 2 Sang L.... Jackson P.K. (Cell 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    9. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. (PubMed id 23446637)1 Barbelanne M....Tsang W.Y. (Hum. Mol. Genet. 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9657 HGNC: 28949 AceView: IQCB1 Ensembl:ENSG00000173226 euGenes: HUgn9657
    ECgene: IQCB1 H-InvDB: IQCB1

    (According to HUGE)
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    HUGE: KIAA0036

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IQCB1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=IQCB1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IQCB1 gene:
    Search GeneIP for patents involving IQCB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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