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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IQCA1 Gene

protein-coding   GIFtS: 46
GCID: GC02M237232

IQ motif containing with AAA domain 1

(Previous name: IQ motif containing with AAA domain )
(Previous symbol: IQCA)
 Explore 1 disease affiliated with
IQCA1 via our new
 Human Malady Compendium 
Biological research products
for IQCA1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
IQ Motif Containing With AAA Domain 11 2
IQCA1 2 3
FLJ225271
IQ Motif Containing With AAA Domain1
4930465P12Rik2
IQ And AAA Domain-Containing Protein 12

External Ids:    HGNC: 261951   Entrez Gene: 797812   Ensembl: ENSG000001323217   UniProtKB: Q86XH13   

Export aliases for IQCA1 gene to outside databases

Previous GC identifers: GC02M236898 GC02M229027


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IQCA1:
The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA)
superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes
and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the
P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
(provided by RefSeq, Jul 2012)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IQCA1 gene promoter:
         MIF-1   CUTL1   HNF-1A   Evi-1   c-Ets-1   SRY   GATA-6   FOXC1   Chx10   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIQCA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IQCA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

IQCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IQCA1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M237232:  view genomic region     (about GC identifiers)

Start:
237,232,794 bp from pter      End:
237,416,185 bp from pter
Size:
183,392 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IQCA1_HUMAN, Q86XH1 (See protein sequence)
Recommended Name: IQ and AAA domain-containing protein 1  
Size: 822 amino acids; 95341 Da
Sequence caution: Sequence=BAB15384.1; Type=Frameshift; Positions=802; Sequence=BAB15384.1; Type=Miscellaneous
discrepancy; Note=Chimeric cDNA; Sequence=BAB70798.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant
splice sites;
Secondary accessions: Q4G164 Q53R37 Q53RV3 Q96NS7 Q9H680
Alternative splicing: 2 isoforms:  Q86XH1-1   Q86XH1-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IQCA1: NX_Q86XH1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86XH1

  • IQCA1 Protein expression data from MOPED and PaxDb:    About this image 
    IQCA1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001257513.1  NP_001257514.1  NP_079002.3  

    ENSEMBL proteins: 
     ENSP00000254653   ENSP00000387347   ENSP00000390964   ENSP00000407213   ENSP00000311951  

    Human Recombinant Protein Products for IQCA1: 
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    Uscn Proteins for IQCA1


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    Uscn ELISAs and CLIAs for IQCA1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IQCA1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003959 ATPase_AAA_core
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q86XH1

    ProtoNet protein and cluster: Q86XH1

    UniProtKB/Swiss-Prot: IQCA1_HUMAN, Q86XH1
    Similarity: Belongs to the AAA ATPase family
    Similarity: Contains 1 IQ domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    IQCA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IQCA1:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IQCA1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidIQCA1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCA1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IQCA1 (ENSP000003873474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAP1ENSP000002469574STRING: ENSP00000246957
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IQCA1
    Search CenterWatch for drugs/clinical trials and news about IQCA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IQCA1 gene (3 alternative transcripts): 
    NM_001270584.1  NM_001270585.1  NM_024726.4  

    Unigene Clusters for IQCA1:

    IQ motif containing with AAA domain 1
    Hs.591594  [show with all ESTs], Hs.621320 , Hs.711488
    Unigene Representative Sequences: BC028699, BC018494, BC008085
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254653(uc002vwb.2 uc002vwa.1) ENST00000409907(uc002vvz.1 uc010zni.1)
    ENST00000409100 ENST00000479783 ENST00000479471 ENST00000418802 ENST00000467572
    ENST00000465621 ENST00000431676 ENST00000309507

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate IQCA1:
    hsa-miR-3163 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidIQCA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IQCA1
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    OriGene siRNA: IQCA1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against IQCA1 
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IQCA1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IQCA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IQCA1

    Additional cDNA sequence: BC008085.1 

    5 DOTS entries:

    DT.100001249  DT.100780186  DT.307788  DT.99933125  DT.120963071 

    24/47 AceView cDNA sequences (see all 47):

    BI753968 BU608197 BC043504 AA909947 BX112211 AW275291 AI522212 BX117697 
    NM_024726 AA884907 BQ186602 AI911448 AI554152 BM968776 BF432029 AW304818 
    AX746673 BM995505 BM995494 AI672139 AI420183 AI219684 CD108451 AK054711 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IQCA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                                                                                                                    -               
    SP2:                                                                                                        -           -               
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for IQCA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IQCA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGACGGACC
    IQCA1 Expression
    About this image

    IQCA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IQCA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IQCA1

    SOURCE GeneReport for Unigene clusters: Hs.591594 Hs.621320 Hs.711488
        SABiosciences Custom PCR Arrays for IQCA1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IQCA1 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iqca1 , 5 IQ motif containing with AAA domain1, 5 78.97(n)1
    78.73(a)1
      1 (45.08 cM)5
    749181  NM_029122.21  NP_083398.21 
     900421325 
    chicken
    (Gallus gallus)
    Aves IQCA11 IQ motif containing with AAA domain 1 65.35(n)
    59.51(a)
      424021  XM_421878.3  XP_421878.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    64(a)
    61(a)
    many → 1
    many → 1
    1(119946216-119953083)
    1(120028889-120052434)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153582 Xenopus laevis transcribed sequence with weak similarity more 78.38(n)    BJ077344.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055163.12   -- 71.78(n)    BC055163.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167891 CG16789 48.19(n)
    39.53(a)
      41154  NM_141653.4  NP_649910.3 


    ENSEMBL Gene Tree for IQCA1 (if available)
    TreeFam Gene Tree for IQCA1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IQCA1 gene
    SPAST2  FIGNL12  FIGN2  
    3 SIMAP similar genes for IQCA1 using alignment to 4 protein entries:     IQCA1_HUMAN (see all proteins):
    FLJ22527    IQCA1P1    IQCA1L

    IQCA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IQCA1
    PGOHUM00000233082


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3047 NCBI SNPs in IQCA1 are shown (see all 3047    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394748601,2
    --237232304(+) GGTCTA/GTGCAG 4 -- ds50010--------
    rs1924955441,2
    --237232396(+) TCTCAA/GTTGAA 4 -- ds50010--------
    rs1492624981,2
    --237232455(+) TTGCTA/GTCTTC 4 -- ds50010--------
    rs1445015581,2
    --237232487(+) TTACAC/TGATTT 4 -- ds50010--------
    rs1396547231,2
    --237232559(+) CTTCAC/TGTCGG 4 -- ds50010--------
    rs1424336141,2
    --237232577(+) TTCTC-/TGCATT 4 -- ds50010--------
    rs1845839981,2
    --237232630(+) GATAAC/TTTTTC 4 -- ds50010--------
    rs1443990471,2
    --237232644(+) CCTTCC/TAGTGA 4 -- ds50010--------
    rs134312811,2
    C,F--237232855(+) AATTTA/TTTAAA 4 -- ut31 nc-transcript-variant7Minor allele frequency- T:0.17WA NA CSA EA 366
    rs568825481,2
    C--237232888(+) TGTAC-/ATGGATT 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for IQCA1 (237232794 - 237416185 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for IQCA1
         2 Indels: 63339 34375

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IQCA1 for disorders           About GeneDecksing

    1 disease for IQCA1:    About MalaCards
    coronary stenosis

    1 disease from the University of Copenhagen DISEASES database for IQCA1:
    Coronary stenosis

    Export disorders for IQCA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IQCA1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IQCA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
    7. The AAA+ superfamily of functionally diverse proteins. (PubMed id 18466635)1 Snider J....Houry W.A. (2008)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79781 HGNC: 26195 AceView: IQCA Ensembl:ENSG00000132321 euGenes: HUgn79781
    ECgene: IQCA1 H-InvDB: IQCA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IQCA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IQCA1 gene:
    Search GeneIP for patents involving IQCA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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