IQCA1 Gene
protein-coding GIFtS : 46
GCID: GC02 M237232
IQ motif containing with AAA domain 1 (Previous name: IQ motif containing with AAA domain ) (Previous symbol: IQCA )
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Aliasesfor IQCA1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases IQ Motif Containing With AAA Domain 1 1 2 IQCA1 2 3 FLJ225271 IQ Motif Containing With AAA Domain1 4930465P12Rik2 IQ And AAA Domain-Containing Protein 12
Export aliases for IQCA1 gene to outside databases Previous GC identifers: GC02M236898 GC02M229027
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Summariesfor IQCA1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for IQCA1 : The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. (provided by RefSeq, Jul 2012)
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Genomic Viewsfor IQCA1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005120.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IQCA1 gene promoter: MIF-1 CUTL1 HNF-1A Evi-1 c-Ets-1 SRY GATA-6 FOXC1 Chx10 ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for IQCA1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCA1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3 IQCA1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M237232: view genomic region
(about GC identifiers )
Start:
237,232,794 bp from pter
End:
237,416,185 bp from pter
Size:
183,392 bases
Orientation:
minus strand
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Proteinsfor IQCA1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IQCA1_HUMAN, Q86XH1 (See
protein sequence )Recommended Name: IQ and AAA domain-containing protein 1 Size : 822 amino acids; 95341 Da
Sequence caution : Sequence=BAB15384.1; Type=Frameshift; Positions=802; Sequence=BAB15384.1; Type=Miscellaneousdiscrepancy; Note=Chimeric cDNA; Sequence=BAB70798.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions : Q4G164 Q53R37 Q53RV3 Q96NS7 Q9H680Alternative splicing : 2 isoforms : Q86XH1-1 Q86XH1-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for IQCA1: NX_Q86XH1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86XH1 IQCA1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts):
NP_001257513.1 NP_001257514.1 NP_079002.3 ENSEMBL proteins: ENSP00000254653 ENSP00000387347 ENSP00000390964 ENSP00000407213 ENSP00000311951 Human Recombinant Protein Products for IQCA1: IQCA1 Antibody Products: Assay Products for IQCA1:
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Protein
Domains / Familiesfor IQCA1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IQCA1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q86XH1 ProtoNet protein and cluster: Q86XH1
UniProtKB/Swiss-Prot: IQCA1_HUMAN, Q86XH1 Similarity : Belongs to the AAA ATPase familySimilarity : Contains 1 IQ domain
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Functionfor IQCA1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005524 ATP binding
IEA --
IQCA1 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for IQCA1 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IQCA1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IQCA1 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IQCA1 (NM_024726 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQCA1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IQCA1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCA1
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Pathways & Interactionsfor IQCA1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IQCA1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for IQCA1 (ENSP00000387347 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor IQCA1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IQCA1 Search CenterWatch for drugs/clinical trials and news about IQCA1
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Transcriptsfor IQCA1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IQCA1 gene (3 alternative transcripts): NM_001270584.1 NM_001270585.1 NM_024726.4 Unigene Clusters for IQCA1:
IQ motif containing with AAA domain 1 Hs.591594 [show with all ESTs ] , Hs.621320 , Hs.711488 Unigene Representative Sequences: BC028699 , BC018494 , BC008085 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000254653 (uc002vwb.2 uc002vwa.1 ) ENST00000409907 (uc002vvz.1 uc010zni.1 )ENST00000409100 ENST00000479783 ENST00000479471 ENST00000418802 ENST00000467572 ENST00000465621 ENST00000431676 ENST00000309507 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IQCA1 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IQCA1 (see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IQCA1 (NM_024726 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IQCA1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IQCA1
Additional cDNA sequence: BC008085.1
5 DOTS entries : DT.100001249 DT.100780186
DT.307788 DT.99933125 DT.120963071 24/47 AceView cDNA sequences (see all 47 ):
BI753968 BU608197 BC043504 AA909947 BX112211 AW275291 AI522212 BX117697 NM_024726 AA884907 BQ186602 AI911448 AI554152 BM968776 BF432029 AW304818 AX746673 BM995505 BM995494 AI672139 AI420183 AI219684 CD108451 AK054711 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for IQCA1 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 SP1 :                                       -       SP2 :                                   -     -       SP3 :                                            
ECgene alternative splicing isoforms for IQCA1
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Expression for IQCA1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IQCA1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGGACGGACCAbout this image IQCA1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Spermatid Germ Cells, Male Gametocytes Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See IQCA1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IQCA1 SOURCE GeneReport for Unigene clusters: Hs.591594 Hs.621320 Hs.711488 SABiosciences Custom PCR Arrays for IQCA1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IQCA1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IQCA1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IQCA1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IQCA1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCA1
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Orthologsfor IQCA1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for IQCA1 gene from 6/23 species (see all 23 ) About this table
ENSEMBL Gene Tree for IQCA1 (if available)TreeFam Gene Tree for IQCA1 (if available)
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Paralogsfor IQCA1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for IQCA1 gene SPAST 2 FIGNL1 2 FIGN 2 3 SIMAP similar genes for IQCA1 using alignment to 4 protein entries: IQCA1_HUMAN (see all proteins ):FLJ22527 IQCA1P1 IQCA1L
IQCA1 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for IQCA1 PGOHUM00000233082
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Genomic Variantsfor IQCA1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IQCA1 (237232794 - 237416185 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for IQCA1 2 Indels : 63339 34375
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IQCA1
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Disorders
/ Diseasesfor IQCA1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IQCA1 for disorders About GeneDecksing 1 disease for IQCA1 : About MalaCards coronary stenosis 1 disease from the University of Copenhagen DISEASES database for IQCA1 :Coronary stenosis Export disorders for IQCA1 gene to outside databases
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Publicationsfor IQCA1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IQCA1 gene integrated from 9 sources : (articles sorted by number of sources associating them with IQCA1) Utopia : connect your pdf to the dynamic world of online information
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536) 1 Barber M.J....Krauss R.M. (2010) The AAA+ superfamily of functionally diverse proteins. (PubMed id 18466635) 1 Snider J....Houry W.A. (2008) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298) 1 Maruyama K. and Sugano S. (1994)
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External Searches for IQCA1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IQCA1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IQCA1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IQCA1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IQCA1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IQCA1 gene: Search GeneIP for patents involving IQCA1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IQCA1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for IQCA1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IQCA1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IQCA1 OriGene Protein Over-expression Lysate for IQCA1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IQCA1 OriGene 3'-UTR Clone for IQCA1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IQCA1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IQCA1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IQCA1 OriGene Custom Protein Services for IQCA1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IQCA1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IQCA1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IQCA1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IQCA1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IQCA1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IQCA1
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IQCA1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IQCA1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IQCA1
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Aliases for IQCA1
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Disorders / Diseases for IQCA1
Domains / Families for IQCA1
Drugs / Compounds for IQCA1
Expression for IQCA1
Function for IQCA1
Genomic Views for IQCA1
Intellectual Property for IQCA1
Orthologs for IQCA1
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Pathways / Interactions for IQCA1
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Proteins for IQCA1
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Summaries for IQCA1
Transcripts for IQCA1
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