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Aliases for IQCA1 Gene

Aliases for IQCA1 Gene

  • IQ Motif Containing With AAA Domain 1 2 3
  • Dynein Regulatory Complex Subunit 11 2 3
  • IQCA 3 4
  • IQ And AAA Domain-Containing Protein 1 3
  • IQ Motif Containing With AAA Domain 2
  • 4930465P12Rik 3
  • DRC11 3

External Ids for IQCA1 Gene

Previous HGNC Symbols for IQCA1 Gene

  • IQCA

Previous GeneCards Identifiers for IQCA1 Gene

  • GC02M236898
  • GC02M237232
  • GC02M229027

Summaries for IQCA1 Gene

Entrez Gene Summary for IQCA1 Gene

  • The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for IQCA1 Gene

IQCA1 (IQ Motif Containing With AAA Domain 1) is a Protein Coding gene. An important paralog of this gene is FIGN.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCA1 Gene

Genomics for IQCA1 Gene

Regulatory Elements for IQCA1 Gene

Genomic Location for IQCA1 Gene

236,324,147 bp from pter
236,507,542 bp from pter
183,396 bases
Minus strand

Genomic View for IQCA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IQCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCA1 Gene

Proteins for IQCA1 Gene

  • Protein details for IQCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ and AAA domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DFH9
    • E7EWQ0
    • Q4G164
    • Q53R37
    • Q53RV3
    • Q96NS7
    • Q9H680

    Protein attributes for IQCA1 Gene

    822 amino acids
    Molecular mass:
    95341 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15384.1; Type=Frameshift; Positions=802; Evidence={ECO:0000305}; Sequence=BAB15384.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=BAB70798.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCA1 Gene


neXtProt entry for IQCA1 Gene

Proteomics data for IQCA1 Gene at MOPED

Post-translational modifications for IQCA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQCA1 Gene

No data available for DME Specific Peptides for IQCA1 Gene

Domains for IQCA1 Gene

Protein Domains for IQCA1 Gene

Suggested Antigen Peptide Sequences for IQCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Belongs to the AAA ATPase family.
  • Contains 1 IQ domain.
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with IQCA1: view

Function for IQCA1 Gene

Gene Ontology (GO) - Molecular Function for IQCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with IQCA1: view

Phenotypes for IQCA1 Gene

GenomeRNAi human phenotypes for IQCA1:
genes like me logo Genes that share phenotypes with IQCA1: view

Animal Model Products

CRISPR Products

miRNA for IQCA1 Gene

miRTarBase miRNAs that target IQCA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQCA1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCA1 Gene

Localization for IQCA1 Gene

Subcellular locations from

Jensen Localization Image for IQCA1 Gene COMPARTMENTS Subcellular localization image for IQCA1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCA1 Gene

Pathways for IQCA1 Gene

SuperPathways for IQCA1 Gene

No Data Available

Interacting Proteins for IQCA1 Gene

Gene Ontology (GO) - Biological Process for IQCA1 Gene


No data available for Pathways by source for IQCA1 Gene

Transcripts for IQCA1 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IQCA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IQCA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: -
SP2: - -

Relevant External Links for IQCA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCA1 Gene

mRNA expression in normal human tissues for IQCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQCA1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.7), Brain - Putamen (basal ganglia) (5.3), Brain - Nucleus accumbens (basal ganglia) (4.7), and Thyroid (4.6).

Protein differential expression in normal tissues for IQCA1 Gene

This gene is overexpressed in Serum (57.7) and Placenta (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IQCA1 Gene

SOURCE GeneReport for Unigene cluster for IQCA1 Gene Hs.591594

genes like me logo Genes that share expressions with IQCA1: view

Expression partners for IQCA1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IQCA1 Gene

Orthologs for IQCA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQCA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IQCA1 35
  • 82.29 (n)
  • 81.87 (a)
IQCA1 36
  • 82 (a)
(Canis familiaris)
Mammalia IQCA1 35
  • 82.66 (n)
  • 82.61 (a)
IQCA1 36
  • 82 (a)
(Mus musculus)
Mammalia Iqca 35
  • 77.85 (n)
  • 76.83 (a)
Iqca 16
Iqca 36
  • 77 (a)
(Pan troglodytes)
Mammalia IQCA1 35
  • 98.82 (n)
  • 98.66 (a)
IQCA1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Iqca1 35
  • 74.18 (n)
  • 73.09 (a)
(Monodelphis domestica)
Mammalia IQCA1 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
-- 36
  • 64 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves IQCA1 35
  • 65.63 (n)
  • 59.43 (a)
IQCA1 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
-- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqca1 35
  • 63.34 (n)
  • 60.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15358 35
(Danio rerio)
Actinopterygii zgc:153738 35
  • 59.67 (n)
  • 55.65 (a)
iqca1 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011967 35
  • 50.31 (n)
  • 41.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16789 35
  • 47.63 (n)
  • 38.5 (a)
CG14183 36
  • 28 (a)
CG16789 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 36
  • 12 (a)
YTA6 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13576 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for IQCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCA1 Gene

Gene Tree for IQCA1 (if available)
Gene Tree for IQCA1 (if available)

Paralogs for IQCA1 Gene

Paralogs for IQCA1 Gene

(2) SIMAP similar genes for IQCA1 Gene using alignment to 3 proteins: Pseudogenes for IQCA1 Gene

genes like me logo Genes that share paralogs with IQCA1: view

Variants for IQCA1 Gene

Sequence variations from dbSNP and Humsavar for IQCA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs766938 -- 236,354,691(-) CAGTG(G/T)GGACA intron-variant
rs900439 -- 236,463,133(+) TACTA(A/C)CATTA intron-variant
rs1078913 -- 236,354,674(-) GACCA(A/G)GGTTT intron-variant
rs1078914 -- 236,354,567(-) GGCTT(C/T)TCCAA intron-variant
rs1108890 -- 236,371,064(-) GCTCT(A/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCA1 Gene

Variant ID Type Subtype PubMed ID
dgv4457n71 CNV Gain 21882294
nsv876039 CNV Gain 21882294
dgv4458n71 CNV Loss 21882294
esv2721703 CNV Deletion 23290073
nsv876041 CNV Gain 21882294
esv2721704 CNV Deletion 23290073
esv2721705 CNV Deletion 23290073
esv2672367 CNV Deletion 23128226
nsv3223 CNV Loss 18451855
esv28807 CNV Loss 19812545
esv2676346 CNV Deletion 23128226
nsv821925 CNV Loss 20364138
nsv834576 CNV Gain 17160897
nsv876043 CNV Gain 21882294

Relevant External Links for IQCA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQCA1 Gene

Disorders for IQCA1 Gene

(1) University of Copenhagen DISEASES for IQCA1 Gene

genes like me logo Genes that share disorders with IQCA1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for IQCA1 Gene

Publications for IQCA1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R. … Porter M.E. (Mol. Biol. Cell 2013) 2 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for IQCA1 Gene

Sources for IQCA1 Gene

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