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Aliases for IQCA1 Gene

Aliases for IQCA1 Gene

  • IQ Motif Containing With AAA Domain 1 2 3 5
  • Dynein Regulatory Complex Subunit 11 2 3
  • IQCA 3 4
  • IQ Motif Containing With AAA Domain 2
  • 4930465P12Rik 3
  • DRC11 3

External Ids for IQCA1 Gene

Previous HGNC Symbols for IQCA1 Gene

  • IQCA

Previous GeneCards Identifiers for IQCA1 Gene

  • GC02M236898
  • GC02M237232
  • GC02M229027

Summaries for IQCA1 Gene

Entrez Gene Summary for IQCA1 Gene

  • The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for IQCA1 Gene

IQCA1 (IQ Motif Containing With AAA Domain 1) is a Protein Coding gene. An important paralog of this gene is FIGN.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQCA1 Gene

Genomics for IQCA1 Gene

Regulatory Elements for IQCA1 Gene

Enhancers for IQCA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IQCA1 on UCSC Golden Path with GeneCards custom track

Promoters for IQCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IQCA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IQCA1 Gene

236,324,147 bp from pter
236,507,552 bp from pter
183,406 bases
Minus strand

Genomic View for IQCA1 Gene

Genes around IQCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IQCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IQCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQCA1 Gene

Proteins for IQCA1 Gene

  • Protein details for IQCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IQ and AAA domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DFH9
    • E7EWQ0
    • Q4G164
    • Q53R37
    • Q53RV3
    • Q96NS7
    • Q9H680

    Protein attributes for IQCA1 Gene

    822 amino acids
    Molecular mass:
    95341 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15384.1; Type=Frameshift; Positions=802; Evidence={ECO:0000305}; Sequence=BAB15384.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=BAB70798.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for IQCA1 Gene


neXtProt entry for IQCA1 Gene

Proteomics data for IQCA1 Gene at MOPED

Post-translational modifications for IQCA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IQCA1 Gene

No data available for DME Specific Peptides for IQCA1 Gene

Domains & Families for IQCA1 Gene

Gene Families for IQCA1 Gene

Protein Domains for IQCA1 Gene

Suggested Antigen Peptide Sequences for IQCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Belongs to the AAA ATPase family.
  • Contains 1 IQ domain.
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with IQCA1: view

Function for IQCA1 Gene

genes like me logo Genes that share phenotypes with IQCA1: view

Animal Model Products

CRISPR Products

miRNA for IQCA1 Gene

miRTarBase miRNAs that target IQCA1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IQCA1 Gene

Localization for IQCA1 Gene

Subcellular locations from

Jensen Localization Image for IQCA1 Gene COMPARTMENTS Subcellular localization image for IQCA1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IQCA1 Gene

Pathways & Interactions for IQCA1 Gene

SuperPathways for IQCA1 Gene

No Data Available

Interacting Proteins for IQCA1 Gene

Gene Ontology (GO) - Biological Process for IQCA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IQCA1 Gene

Drugs & Compounds for IQCA1 Gene

No Compound Related Data Available

Transcripts for IQCA1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IQCA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: -
SP2: - -

Relevant External Links for IQCA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IQCA1 Gene

mRNA expression in normal human tissues for IQCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQCA1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.7), Brain - Putamen (basal ganglia) (x5.3), Brain - Nucleus accumbens (basal ganglia) (x4.7), and Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for IQCA1 Gene

This gene is overexpressed in Serum (57.7) and Placenta (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IQCA1 Gene

SOURCE GeneReport for Unigene cluster for IQCA1 Gene Hs.591594

genes like me logo Genes that share expression patterns with IQCA1: view

Protein tissue co-expression partners for IQCA1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IQCA1 Gene

Orthologs for IQCA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQCA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IQCA1 35
  • 82.29 (n)
  • 81.87 (a)
IQCA1 36
  • 82 (a)
(Canis familiaris)
Mammalia IQCA1 35
  • 82.66 (n)
  • 82.61 (a)
IQCA1 36
  • 82 (a)
(Mus musculus)
Mammalia Iqca 35
  • 77.85 (n)
  • 76.83 (a)
Iqca 16
Iqca 36
  • 77 (a)
(Pan troglodytes)
Mammalia IQCA1 35
  • 98.82 (n)
  • 98.66 (a)
IQCA1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Iqca1 35
  • 74.18 (n)
  • 73.09 (a)
(Monodelphis domestica)
Mammalia IQCA1 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
-- 36
  • 64 (a)
-- 36
  • 69 (a)
(Gallus gallus)
Aves IQCA1 35
  • 65.63 (n)
  • 59.43 (a)
IQCA1 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
-- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia iqca1 35
  • 63.34 (n)
  • 60.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15358 35
(Danio rerio)
Actinopterygii zgc:153738 35
  • 59.67 (n)
  • 55.65 (a)
iqca1 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011967 35
  • 50.31 (n)
  • 41.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16789 35
  • 47.63 (n)
  • 38.5 (a)
CG14183 36
  • 28 (a)
CG16789 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAP1 36
  • 12 (a)
YTA6 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13576 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for IQCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IQCA1 Gene

Gene Tree for IQCA1 (if available)
Gene Tree for IQCA1 (if available)

Paralogs for IQCA1 Gene

Paralogs for IQCA1 Gene

(2) SIMAP similar genes for IQCA1 Gene using alignment to 3 proteins: Pseudogenes for IQCA1 Gene

genes like me logo Genes that share paralogs with IQCA1: view

Variants for IQCA1 Gene

Sequence variations from dbSNP and Humsavar for IQCA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10204742 - 236,392,034(+) CTAGC(C/T)TTAAG nc-transcript-variant, reference, missense
rs35114730 - 236,497,476(+) ACATC(A/T)TATTA nc-transcript-variant, reference, missense
rs3754644 - 236,419,198(+) TGGGT(C/T)GTTTT intron-variant, nc-transcript-variant, reference, missense
rs1586094 -- 236,432,923(+) GATCC(A/T)TTTGG intron-variant
rs1807773 -- 236,493,153(-) GCACA(A/G)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IQCA1 Gene

Variant ID Type Subtype PubMed ID
dgv4457n71 CNV Gain 21882294
nsv876039 CNV Gain 21882294
dgv4458n71 CNV Loss 21882294
esv2721703 CNV Deletion 23290073
nsv876041 CNV Gain 21882294
esv2721704 CNV Deletion 23290073
esv2721705 CNV Deletion 23290073
esv2672367 CNV Deletion 23128226
nsv3223 CNV Loss 18451855
esv28807 CNV Loss 19812545
esv2676346 CNV Deletion 23128226
nsv821925 CNV Loss 20364138
nsv834576 CNV Gain 17160897
nsv876043 CNV Gain 21882294

Variation tolerance for IQCA1 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IQCA1 Gene

Disorders for IQCA1 Gene

Relevant External Links for IQCA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IQCA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IQCA1 Gene

Publications for IQCA1 Gene

  1. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. (PMID: 23427265) Bower R. … Porter M.E. (Mol. Biol. Cell 2013) 2 3 67
  2. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3
  3. The AAA+ superfamily of functionally diverse proteins. (PMID: 18466635) Snider J. … Houry W.A. (Genome Biol. 2008) 3
  4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for IQCA1 Gene

Sources for IQCA1 Gene