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IQCA1 Gene

protein-coding GIFtS: 41

GC02M236898

IQ motif containing with AAA domain 1
(Previous name: IQ motif containing with AAA domain )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IQCA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
4930465P12Rik ^²
FLJ22527 ^¹, ²
IQCA ^²

Descriptions
IQ motif containing with AAA domain ^¹
IQ motif containing with AAA domain 1 ^²

External Ids
HGNC: 26195¹
Entrez Gene: 79781²
UniProtKB: Q86XH1³
Ensembl: ENSG00000132321⁷

Search outside databases for aliases for IQCA1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.2-q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3

IQCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M236898: (about GC identifiers)

Start:	236,897,533 bp from pter
End:	237,080,924 bp from pter
Size:	183,392 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005120.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IQCA_HUMAN, Q86XH1 (See protein sequence)

Recommended Name: IQ and AAA domain-containing protein

Size: 822 amino acids; 95341 Da

Sequence caution: Sequence=BAB15384.1; Type=Frameshift; Positions=802; Sequence=BAB15384.1;

Type=Miscellaneous discrepancy; Note=Chimeric cDNA; Sequence=BAB70798.1; Type=Miscellaneous

discrepancy; Note=Unlikely isoform. Aberrant splice sites;

Secondary accessions: Q4G164 Q53R37 Q53RV3 Q96NS7 Q9H680

Alternative splicing: 2 isoforms: Q86XH1-1 Q86XH1-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079002.3

ENSEMBL proteins:

ENSP00000311951 ENSP00000387347 ENSP00000387014 ENSP00000254653

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for IQCA1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (IQCA)
	Novus Biologicals Antibody for IQCA1

Assays for IQCA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86XH1

ProtoNet protein and cluster: Q86XH1

UniProtKB/Swiss-Prot: IQCA_HUMAN, Q86XH1

Similarity: Belongs to the AAA ATPase family

Similarity: Contains 1 IQ domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IQCA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC028699

Applied Biosystems Silencer® siRNAs for IQCA1

Sigma-Aldrich siRNA for IQCA1

Sigma-Aldrich shRNA for IQCA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IQCA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024726
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024726
untagged cDNA clones in CMV expression vector (see all 3): BC028699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024726

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IQCA1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IQCA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC028699

Sigma-Aldrich siRNA for IQCA1

Sigma-Aldrich shRNA for IQCA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024726

REFSEQ mRNAs for IQCA1 gene:

NM_024726.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024726

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024726
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024726
                                 untagged cDNA clones in CMV expression vector (see all 3): BC028699

Additional cDNA sequence: BC008085.1

5 DOTS entries:

DT.100001249 DT.100780186 DT.99933125 DT.307788 DT.120963071

24/47 AceView cDNA sequences (see all 47 ):

BC043504 AA884907 NM_024726 AI522212 BX112211 BI753968 BQ186602 AW275291

AA909947 BX117697 BU608197 BG772346 BM968776 BM995505 BF432029 CD108451

BM995494 AI420183 AW304818 AK054711 BC028699 AK090907 AX746673 AI554152

Unigene Clusters for IQCA1:

IQ motif containing with AAA domain 1

Hs.591594 [show with all ESTs], Hs.621320 , Hs.711488

Unigene Representative Sequences: BC028699, BC018494, BC008085

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IQCA1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20
SP1:																																							-
SP2:																																			-				-
SP3:

About this scheme

ECgene alternative splicing isoforms for IQCA1

4 Ensembl transcripts including schematic representations:

ENST00000309507 ENST00000409907 ENST00000409100 ENST00000254653

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IQCA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IQCA1

¹ / ²

8 probe-sets matching IQCA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80923_at²	U95-E	1	1.00	1.00	0.66	1.32	--	--	--	--	--
85388_at²	U95-D	1	1.00	1.00	0.66	0.70	--	--	--	--	--
238584_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
220274_at²	U133-A	2	1.00	0.73	--	--	--	--	--	--	--
1561485_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238584_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1562130_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220274_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGACGGACC

SOURCE GeneReport for Unigene clusters: Hs.591594 Hs.621320 Hs.711488

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IQCA1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IQCA1¹	--	IQ motif containing with AAA domain 1	83.7(n) 83.99(a)	477415 XM_534611.2 XP_534611.2
chimpanzee (Pan troglodytes)	IQCA1¹	--	IQ motif containing with AAA domain 1	99.27(n) 99.15(a)	460042 XM_001152559.1 XP_001152559.1
cow (Bos taurus)	IQCA1¹	--	IQ motif containing with AAA domain 1	81.58(n) 79.59(a)	618116 XM_870442.2 XP_875535.2
rat (Rattus norvegicus)	RGD1305311¹	--	similar to hypothetical protein FLJ22527	78.1(n) 78.8(a)	316616 XM_237386.4 XP_237386.4
mouse (Mus musculus)	Iqca¹	--	IQ motif containing with AAA domain	78.97(n) 78.73(a)	74918 XM_001475953.1 XP_001476003.1

About this table Species with no ortholog for IQCA1

ENSEMBL Gene Tree for IQCA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IQCA1 gene

IQCA1L²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/738 NCBI SNPs in IQCA1 are shown (see all 738 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 161)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6431452^1,2	A,C,F,H	236897917(+)	`ACCTGC/AACACT`	1	--	ut3¹ ese³		7		EU EA WA NA	544
	rs10204742^1,2	C,F,H	236965416(+)	`CTAGCT/CTTAAG`	1	R/K	mis¹ ese³		9		EU EA WA NA	916
	rs35114730^1,2	C,F	237070858(+)	`ACATCT/ATATTA`	1	M/K	mis¹		5		NA EU EA WA	484
--	rs10193029^1,2	A	237082169(+)	`GAGCCC/TGGAAG`	1	--	ng3¹		0	--	--	--	--
--	rs10193278^1,2	A	237082651(+)	`cgcctA/Gccacc`	1	--	ng3¹		0	--	--	--	--
--	rs13416077^1,2	A	237082779(+)	`attacA/Tggcgt`	1	--	ng3¹		0	--	--	--	--
--	rs3754644^1,2	F	236992580(+)	`TGGGTT/CGTTTT`	1	R/Q	mis¹		1		EA	1498
--	rs10203752^1,2	A	237082387(+)	`ccactA/Gtctaa`	1	--	ng3¹		0	--	--	--	--
	rs35858356^1,2	F	237070791(+)	`TGTGGT/CTCAAT`	1	E/E	syn¹		1		NA	56
	rs35432941^1,2	F	237039048(+)	`TCAGCC/TTGGAT`	1	Q/Q	syn¹		1		NA	68

About this table

HapMap Linkage Disequilibrium images for IQCA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for IQCA1 gene:

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)³ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79781	HGNC: 26195	AceView: IQCA	Ensembl:ENSG00000132321	euGenes: HUgn79781
ECgene: IQCA1	H-InvDB: IQCA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IQCA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IQCA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IQCA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IQCA1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IQCA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for IQCA1

Search Tocris compounds for IQCA1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IQCA1

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IQCA1 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for IQCA1

Summaries
for IQCA1

Genomic Location
for IQCA1

Proteins
for IQCA1

Protein Domains/
Families
for IQCA1

Gene Function
for IQCA1

Pathways & Interactions
for IQCA1

Drugs & Compounds
for IQCA1

Transcripts
for IQCA1

Expression
for IQCA1

Orthologs
for IQCA1

Paralogs
for IQCA1

SNPs/Variants
for IQCA1

Disorders & Mutations
for IQCA1

Medical News
for IQCA1

Publications
for IQCA1

Search for IQCA1

Genome Databases showing IQCA1

Other Databases showing IQCA1

Specialized Databases showing IQCA1

Licensable Technologies
for IQCA1

Services
for IQCA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IQCA1 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor IQCA1

Summariesfor IQCA1

Genomic Locationfor IQCA1

Proteinsfor IQCA1

Protein Domains/Familiesfor IQCA1

Gene Functionfor IQCA1

Pathways & Interactionsfor IQCA1

Drugs & Compoundsfor IQCA1

Transcriptsfor IQCA1

Expression for IQCA1

Orthologsfor IQCA1

Paralogsfor IQCA1

SNPs/Variantsfor IQCA1

Disorders & Mutationsfor IQCA1

Medical Newsfor IQCA1

Publicationsfor IQCA1

Search for IQCA1

Genome Databases showing IQCA1

Other Databases showing IQCA1

Specialized Databases showing IQCA1

Licensable Technologiesfor IQCA1

Servicesfor IQCA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IQCA1

Summaries
for IQCA1

Genomic Location
for IQCA1

Proteins
for IQCA1

Protein Domains/
Families
for IQCA1

Gene Function
for IQCA1

Pathways & Interactions
for IQCA1

Drugs & Compounds
for IQCA1

Transcripts
for IQCA1

Expression
for IQCA1

Orthologs
for IQCA1

Paralogs
for IQCA1

SNPs/Variants
for IQCA1

Disorders & Mutations
for IQCA1

Medical News
for IQCA1

Publications
for IQCA1

Licensable Technologies
for IQCA1

Services
for IQCA1