Aliases for IPPK Gene
External Ids for IPPK Gene
Previous HGNC Symbols for IPPK Gene
Previous GeneCards Identifiers for IPPK Gene
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
GeneCards Summary for IPPK Gene
IPPK (Inositol-Pentakisphosphate 2-Kinase) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol pentakisphosphate 2-kinase activity.
UniProtKB/Swiss-Prot for IPPK Gene
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.