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Aliases for IPP Gene

Aliases for IPP Gene

  • Intracisternal A Particle-Promoted Polypeptide 2 3 4 5
  • Kelch-Like Family Member 27 2 3
  • Kelch-Like Protein 27 3 4
  • KLHL27 3 4
  • Actin-Binding Protein IPP 3

External Ids for IPP Gene

Previous GeneCards Identifiers for IPP Gene

  • GC01M045891
  • GC01M045164
  • GC01M045594
  • GC01M045577
  • GC01M045829
  • GC01M046159
  • GC01M044271

Summaries for IPP Gene

Entrez Gene Summary for IPP Gene

  • The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPP Gene

IPP (Intracisternal A Particle-Promoted Polypeptide) is a Protein Coding gene. Diseases associated with IPP include Cardiac Tamponade and Peroneal Nerve Paralysis. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL7.

UniProtKB/Swiss-Prot for IPP Gene

  • May play a role in organizing the actin cytoskeleton.

Additional gene information for IPP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPP Gene

Genomics for IPP Gene

Regulatory Elements for IPP Gene

Enhancers for IPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H045684 1.4 ENCODE dbSUPER 18 +63.8 63803 5 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D LRRC41 TOE1 GPBP1L1 RPS8 EFCAB14-AS1 MAST2 RPL7AP16 HECTD3 IPP NSUN4
GH01H046246 1.4 FANTOM5 ENCODE 12.9 -497.2 -497197 3 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 LRRC41 TOE1 GPBP1L1 EFCAB14-AS1 NSUN4 NASP MUTYH RPL7AP16 IPP RPS15AP10
GH01H045801 1.4 FANTOM5 ENCODE 12 -53.0 -52952 3 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 SLC30A9 ZNF766 ZNF143 FOS CCDC163 MAST2 IPP TMA16P2
GH01H044985 1.2 ENCODE 12.8 +764.4 764428 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TOE1 GPBP1L1 RPS8 HECTD3 TMA16P2 RPL7AP16 UROD IPP RPS15AP10 TMEM69
GH01H044818 1.4 ENCODE dbSUPER 10.7 +930.8 930836 2 HNRNPUL1 HDGF PKNOX1 ARNT ZFP64 ARID4B YY1 SLC30A9 ZNF766 ZNF143 TOE1 GPBP1L1 MUTYH RPL7AP16 DMAP1 HECTD3 RPS8 NASP KIF2C BEST4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IPP on UCSC Golden Path with GeneCards custom track

Promoters for IPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005885 213 1601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for IPP Gene

Chromosome:
1
Start:
45,694,324 bp from pter
End:
45,750,813 bp from pter
Size:
56,490 bases
Orientation:
Minus strand

Genomic View for IPP Gene

Genes around IPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPP Gene

Proteins for IPP Gene

  • Protein details for IPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y573-IPP_HUMAN
    Recommended name:
    Actin-binding protein IPP
    Protein Accession:
    Q9Y573
    Secondary Accessions:
    • A2A6V4
    • D3DQ11
    • Q8N5C3

    Protein attributes for IPP Gene

    Size:
    584 amino acids
    Molecular mass:
    65261 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPP Gene

Post-translational modifications for IPP Gene

  • Ubiquitination at posLast=238238 and isoforms=2279
  • Modification sites at PhosphoSitePlus

Other Protein References for IPP Gene

No data available for DME Specific Peptides for IPP Gene

Domains & Families for IPP Gene

Gene Families for IPP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for IPP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IPP: view

No data available for UniProtKB/Swiss-Prot for IPP Gene

Function for IPP Gene

Molecular function for IPP Gene

GENATLAS Biochemistry:
intracisternal A-particle (IAP)-promoted,placenta,mouse homolog,Kelch family member
UniProtKB/Swiss-Prot Function:
May play a role in organizing the actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with IPP: view
genes like me logo Genes that share phenotypes with IPP: view

Animal Models for IPP Gene

MGI Knock Outs for IPP:
  • Ipp tm1.1(KOMP)Vlcg

Animal Model Products

CRISPR Products

miRNA for IPP Gene

miRTarBase miRNAs that target IPP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPP Gene

Localization for IPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPP Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPP gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton TAS 10072760
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with IPP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IPP Gene

Pathways & Interactions for IPP Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with IPP: view

No data available for Pathways by source and SIGNOR curated interactions for IPP Gene

Drugs & Compounds for IPP Gene

No Compound Related Data Available

Transcripts for IPP Gene

Unigene Clusters for IPP Gene

Intracisternal A particle-promoted polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IPP Gene

No ASD Table

Relevant External Links for IPP Gene

GeneLoc Exon Structure for
IPP
ECgene alternative splicing isoforms for
IPP

Expression for IPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPP Gene

Protein differential expression in normal tissues from HIPED for IPP Gene

This gene is overexpressed in Heart (50.1) and Placenta (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPP Gene



Protein tissue co-expression partners for IPP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPP Gene:

IPP

SOURCE GeneReport for Unigene cluster for IPP Gene:

Hs.744252

Evidence on tissue expression from TISSUES for IPP Gene

  • Thyroid gland(4.2)
  • Blood(2.2)
  • Nervous system(2.2)
  • Intestine(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with IPP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPP Gene

Orthologs for IPP Gene

This gene was present in the common ancestor of animals.

Orthologs for IPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPP 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia IPP 33 34
  • 94.92 (n)
cow
(Bos Taurus)
Mammalia IPP 33 34
  • 93.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IPP 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipp 33 16 34
  • 89.5 (n)
rat
(Rattus norvegicus)
Mammalia Ipp 33
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia IPP 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPP 33 34
  • 75.59 (n)
lizard
(Anolis carolinensis)
Reptilia IPP 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipp 33
  • 70.43 (n)
zebrafish
(Danio rerio)
Actinopterygii ipp 33 34
  • 67.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2413 33
fruit fly
(Drosophila melanogaster)
Insecta CG9426 35 33 34
  • 48.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009913 33
  • 47.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
CSA.6551 34
  • 30 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
CSA.2774 34
  • 27 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
Species where no ortholog for IPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPP Gene

ENSEMBL:
Gene Tree for IPP (if available)
TreeFam:
Gene Tree for IPP (if available)

Paralogs for IPP Gene

Paralogs for IPP Gene

(16) SIMAP similar genes for IPP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IPP: view

Variants for IPP Gene

Sequence variations from dbSNP and Humsavar for IPP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000011065 -- 45,709,057(+) AGGAG(-/A)AAAAA intron-variant
rs1000013616 -- 45,696,316(+) CATTT(C/G/T)TCAAA intron-variant, utr-variant-3-prime
rs1000129756 -- 45,740,145(+) TAAGG(C/T)CATAG intron-variant
rs1000193583 -- 45,742,240(+) GAGGG(G/T)AAAGA intron-variant
rs1000222642 -- 45,740,558(+) ACCCC(C/G)CCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPP Gene

Variant ID Type Subtype PubMed ID
dgv159n100 CNV gain 25217958
esv1007960 CNV insertion 20482838
esv1730955 CNV deletion 17803354
esv2023284 CNV deletion 18987734
esv2747830 CNV deletion 23290073
esv3561582 CNV deletion 23714750
esv3577360 CNV gain 25503493
esv3577471 CNV gain 25503493
esv3585914 CNV gain 21293372
esv3585915 CNV gain 21293372
esv3585916 CNV gain 21293372
esv3893512 CNV gain 25118596
esv4646 CNV loss 18987735
nsv1014128 CNV gain 25217958
nsv1113112 CNV deletion 24896259
nsv1149283 CNV deletion 26484159
nsv159558 CNV deletion 16902084
nsv436781 CNV insertion 17901297
nsv945922 CNV duplication 23825009

Variation tolerance for IPP Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPP Gene

Disorders for IPP Gene

MalaCards: The human disease database

(2) MalaCards diseases for IPP Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiac tamponade
  • pericardial tamponade
peroneal nerve paralysis
  • peroneal nerve palsy
- elite association - COSMIC cancer census association via MalaCards
Search IPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for IPP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPP
genes like me logo Genes that share disorders with IPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPP Gene

Publications for IPP Gene

  1. The IPP gene is assigned to human chromosome 1p32-1p22. (PMID: 8432546) Chang-Yeh A … Huang RC (Genomics 1993) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. (PMID: 10072760) Kim IF … Huang RC (Gene 1999) 3 4 60
  4. Cell lineage-specific expression of the MIPP gene. (PMID: 1905535) Mold DE … Huang RC (Biochemical and biophysical research communications 1991) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for IPP Gene

Sources for IPP Gene

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