IPP Gene
protein-coding GIFtS: 51
GCID: GC01M046159
|
|
intracisternal A particle-promoted polypeptide
| |
Aliases
for IPP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Intracisternal A Particle-Promoted Polypeptide1 2 3 | | KLHL271 2 3 | | Kelch-Like Protein 272 3 | | Actin-Binding Protein IPP2 | | Kelch-Like Family Member 272 |
Export aliases for IPP gene to outside databasesPrevious GC identifers: GC01M045891 GC01M045164 GC01M045594 GC01M045577 GC01M045829 GC01M044271 |
Summaries
for IPP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IPP:
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acidrepeat which interacts with actin. Transcript variants have been described but their full-length nature has not beendetermined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IPP_HUMAN, Q9Y573Function: May play a role in organizing the actin cytoskeleton
|
Genomic Views
for IPP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IPP gene promoter:
ER-alpha AML1a AP-1 POU3F1 SREBP-1c ATF-2 SREBP-1b FOXC1 SREBP-1a c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for IPP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34-p32 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34-p32IPP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M046159: view genomic region
(about GC identifiers)
Start:
|
46,159,996 bp from pter |
End:
|
46,216,485 bp from pter |
Size:
|
56,490 bases |
Orientation:
|
minus strand |
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Proteins
for IPP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IPP_HUMAN, Q9Y573 (See
protein sequence)Recommended Name: Actin-binding protein IPP Size: 584 amino acids; 65261 Da
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: A2A6V4 D3DQ11 Q8N5C3Alternative splicing: 2 isoforms: Q9Y573-1 Q9Y573-2 Explore the universe of human proteins at neXtProt for IPP: NX_Q9Y573
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y573
IPP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138821.1 NP_005888.1
ENSEMBL proteins: ENSP00000353024 ENSP00000379739
Human Recombinant Protein Products for IPP:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IPP for ontologies About GeneDecksing
IPP Antibody Products:
Assay Products for IPP: |
Protein
Domains /
Families
for IPP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IPP for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9Y573ProtoNet protein and cluster: Q9Y573 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: IPP_HUMAN, Q9Y573Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for IPP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: IPP_HUMAN, Q9Y573Function: May play a role in organizing the actin cytoskeleton Genatlas biochemistry entry for IPP:intracisternal A-particle (IAP)-promoted,placenta,mouse homolog,Kelch family member
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- |
IPP for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for IPP:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPP (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for IPP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPP |
|
Pathways & Interactions
for IPP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IPP
1 Interacting protein for IPP (Q9Y5733) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for IPP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IPP
Search CenterWatch for drugs/clinical trials and news about IPP
|
Transcripts
for IPP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IPP gene (2 alternative transcripts): NM_001145349.1 NM_005897.2 Unigene Cluster for IPP: Intracisternal A particle-promoted polypeptide Hs.744252 [show with all ESTs]Unigene Representative Sequence: NM_0058974 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359942(uc001cos.4) ENST00000495072 ENST00000461718 ENST00000396478(uc001cou.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPP (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IPP (NM_001145349) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IPP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPP |
Additional cDNA sequence: AF156857.1 AK023880.1 BC032544.1 3 DOTS entries: DT.430703 DT.100732539 DT.100019653 18 AceView cDNA sequences: AU141321 BM832170 BM833305 BQ788131 BM468310 BX472610 BQ777465 BM509814 BE545147 BF934855 AA346876 BI766417 BM754282 AK023880 BC032544 AF156857 NM_005897 CB992320
GeneLoc Exon Structure
|
Expression
for IPP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IPP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACCTGTC
About this image
See IPP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IPP
SOURCE GeneReport for Unigene cluster: Hs.744252
SABiosciences Custom PCR Arrays for IPP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPP |
Orthologs
for IPP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IPP gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for IPP (if available)
TreeFam Gene Tree for IPP (if available) |
Paralogs
for IPP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IPP gene
- KLHL172 KLHL182 KLHL202 KLHL52 KLHL122 KEAP12 KLHL282 KLHL42
- KLHL32 KLHL82 KLHL102 KLHL12 KLHL22
16 SIMAP similar genes for IPP using alignment to 1 protein entry: IPP_HUMAN:KLHL12 KLHL4 KLHL5 KLHL1 KEAP1 KLHL17
KLHL20 KLHL28 KLHL3 KLHL2 DKFZp686P15123 KLHL18
KLHL8 DKFZp686H07112 KLHL10 KLHL7
IPP for paralogs About GeneDecksing
|
Genomic Variants
for IPP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IPP (46159996 - 46216485 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for IPP
1 CNV: 22967
5 Indels: 39597 11393 24213 44586 42197 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPP |
|
Disorders
/ Diseases
for IPP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IPP for disorders About GeneDecksing
OMIM gene information: 147485
OMIM disorders: --
10  diseases for IPP: About MalaCardsperoneal nerve paralysis placenta praevia cardiac tamponade precocious puberty
gastroesophageal reflux disease peyronie's disease peyronies disease impotence
paralysis carcinoma
2 diseases from the University of Copenhagen DISEASES database for IPP:Peyronie's disease Cardiac tamponade Export disorders for IPP gene to outside databases
|
Publications
for IPP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IPP gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with IPP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The IPP gene is assigned to human chromosome 1p32-1p2 2. (PubMed id 8432546)1, 2, 3 Chang-Yeh A....Huang R.C. (1993)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. (PubMed id 10072760)1, 2 Kim I.F.... Huang R.C. (1999)
- Cell lineage-specific expression of the MIPP gene. (PubMed id 1905535)1, 3 Mold D.E....Huang R.C. (1991)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
|
External Searches for IPP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IPP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IPP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IPP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IPP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IPP gene:
Search GeneIP for patents involving IPP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IPP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IPP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPP | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IPP | | OriGene 3'-UTR Clone for IPP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IPP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPP |
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| |  |  |  |  | | | | | | Recombinant Protein for IPP |
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 | | | IPP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPP |
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