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Aliases for IPP Gene

Aliases for IPP Gene

  • Intracisternal A Particle-Promoted Polypeptide 2 3 4 5
  • Kelch-Like Family Member 27 2 3
  • Kelch-Like Protein 27 3 4
  • KLHL27 3 4
  • Actin-Binding Protein IPP 3

External Ids for IPP Gene

Previous GeneCards Identifiers for IPP Gene

  • GC01M045891
  • GC01M045164
  • GC01M045594
  • GC01M045577
  • GC01M045829
  • GC01M046159
  • GC01M044271

Summaries for IPP Gene

Entrez Gene Summary for IPP Gene

  • The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPP Gene

IPP (Intracisternal A Particle-Promoted Polypeptide) is a Protein Coding gene. Diseases associated with IPP include Peroneal Nerve Paralysis. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL7.

UniProtKB/Swiss-Prot for IPP Gene

  • May play a role in organizing the actin cytoskeleton.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPP Gene

Genomics for IPP Gene

Regulatory Elements for IPP Gene

Enhancers for IPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IPP on UCSC Golden Path with GeneCards custom track

Promoters for IPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for IPP Gene

45,694,324 bp from pter
45,750,813 bp from pter
56,490 bases
Minus strand

Genomic View for IPP Gene

Genes around IPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPP Gene

Proteins for IPP Gene

  • Protein details for IPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-binding protein IPP
    Protein Accession:
    Secondary Accessions:
    • A2A6V4
    • D3DQ11
    • Q8N5C3

    Protein attributes for IPP Gene

    584 amino acids
    Molecular mass:
    65261 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IPP Gene


neXtProt entry for IPP Gene

Post-translational modifications for IPP Gene

  • Ubiquitination at Lys 238 and Lys 279
  • Modification sites at PhosphoSitePlus

Other Protein References for IPP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPP Gene

Domains & Families for IPP Gene

Gene Families for IPP Gene

Suggested Antigen Peptide Sequences for IPP Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with IPP: view

Function for IPP Gene

Molecular function for IPP Gene

GENATLAS Biochemistry:
intracisternal A-particle (IAP)-promoted,placenta,mouse homolog,Kelch family member
UniProtKB/Swiss-Prot Function:
May play a role in organizing the actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with IPP: view
genes like me logo Genes that share phenotypes with IPP: view

Animal Model Products

CRISPR Products

miRNA for IPP Gene

miRTarBase miRNAs that target IPP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPP Gene

Localization for IPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPP Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for IPP Gene COMPARTMENTS Subcellular localization image for IPP gene
Compartment Confidence
cytoskeleton 5
cytosol 4
chloroplast 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton TAS 10072760
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with IPP: view

Pathways & Interactions for IPP Gene

SuperPathways for IPP Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with IPP: view

No data available for Pathways by source and SIGNOR curated interactions for IPP Gene

Drugs & Compounds for IPP Gene

No Compound Related Data Available

Transcripts for IPP Gene

mRNA/cDNA for IPP Gene

Unigene Clusters for IPP Gene

Intracisternal A particle-promoted polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPP Gene

No ASD Table

Relevant External Links for IPP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IPP Gene

mRNA expression in normal human tissues for IPP Gene

Protein differential expression in normal tissues from HIPED for IPP Gene

This gene is overexpressed in Heart (50.1) and Placenta (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPP Gene

Protein tissue co-expression partners for IPP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPP Gene:


SOURCE GeneReport for Unigene cluster for IPP Gene:

genes like me logo Genes that share expression patterns with IPP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPP Gene

Orthologs for IPP Gene

This gene was present in the common ancestor of animals.

Orthologs for IPP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IPP 34
  • 93.95 (n)
  • 95.89 (a)
IPP 35
  • 96 (a)
(Canis familiaris)
Mammalia IPP 34
  • 94.92 (n)
  • 97.26 (a)
IPP 35
  • 95 (a)
(Mus musculus)
Mammalia Ipp 34
  • 89.5 (n)
  • 93.49 (a)
Ipp 16
Ipp 35
  • 93 (a)
(Pan troglodytes)
Mammalia IPP 34
  • 99.76 (n)
  • 99.82 (a)
IPP 35
  • 95 (a)
(Rattus norvegicus)
Mammalia Ipp 34
  • 89.33 (n)
  • 93.66 (a)
(Monodelphis domestica)
Mammalia IPP 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia IPP 35
  • 91 (a)
(Gallus gallus)
Aves IPP 34
  • 75.59 (n)
  • 83.36 (a)
IPP 35
  • 80 (a)
(Anolis carolinensis)
Reptilia IPP 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ipp 34
  • 70.43 (n)
  • 69.73 (a)
(Danio rerio)
Actinopterygii ipp 34
  • 67.69 (n)
  • 71.58 (a)
ipp 35
  • 62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2413 34
fruit fly
(Drosophila melanogaster)
Insecta CG9426 36
  • 37 (a)
CG9426 34
  • 48.4 (n)
  • 38.52 (a)
CG9426 35
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009913 34
  • 47.39 (n)
  • 38.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
-- 35
  • 31 (a)
-- 35
  • 25 (a)
-- 35
  • 34 (a)
-- 35
  • 32 (a)
-- 35
  • 25 (a)
-- 35
  • 22 (a)
-- 35
  • 29 (a)
-- 35
  • 31 (a)
CSA.2774 35
  • 27 (a)
CSA.6551 35
  • 30 (a)
Species where no ortholog for IPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPP Gene

Gene Tree for IPP (if available)
Gene Tree for IPP (if available)

Paralogs for IPP Gene

Paralogs for IPP Gene

(16) SIMAP similar genes for IPP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IPP: view

Variants for IPP Gene

Sequence variations from dbSNP and Humsavar for IPP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs28375469 - 45,729,703(+) GAGAT(C/T)TGCAT reference, missense
rs1135260 -- 45,699,006(-) ctcac(A/G)cctgt intron-variant, utr-variant-3-prime
rs1135261 -- 45,699,000(-) cctgt(A/G)atccc intron-variant, utr-variant-3-prime
rs1135262 -- 45,698,999(-) ctgta(A/G)tccca intron-variant, utr-variant-3-prime
rs3014243 -- 45,698,302(-) AAAAA(A/T)TTTTT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IPP Gene

Variant ID Type Subtype PubMed ID
dgv159n100 CNV gain 25217958
esv1007960 CNV insertion 20482838
esv1730955 CNV deletion 17803354
esv2023284 CNV deletion 18987734
esv2747830 CNV deletion 23290073
esv3561582 CNV deletion 23714750
esv3577360 CNV gain 25503493
esv3577471 CNV gain 25503493
esv3585914 CNV gain 21293372
esv3585915 CNV gain 21293372
esv3585916 CNV gain 21293372
esv3893512 CNV gain 25118596
esv4646 CNV loss 18987735
nsv1014128 CNV gain 25217958
nsv1113112 CNV deletion 24896259
nsv1149283 CNV deletion 26484159
nsv159558 CNV deletion 16902084
nsv436781 CNV insertion 17901297
nsv945922 CNV duplication 23825009

Variation tolerance for IPP Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPP Gene

Disorders for IPP Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPP Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroneal nerve paralysis
  • peroneal nerve palsy
- elite association - COSMIC cancer census association via MalaCards
Search IPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for IPP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPP Gene

Publications for IPP Gene

  1. The IPP gene is assigned to human chromosome 1p32-1p22. (PMID: 8432546) Chang-Yeh A. … Huang R.C. (Genomics 1993) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. (PMID: 10072760) Kim I.F. … Huang R.C. (Gene 1999) 3 4 65
  4. Cell lineage-specific expression of the MIPP gene. (PMID: 1905535) Mold D.E. … Huang R.C. (Biochem. Biophys. Res. Commun. 1991) 2 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for IPP Gene

Sources for IPP Gene

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