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Aliases for IPP Gene

Aliases for IPP Gene

  • Intracisternal A Particle-Promoted Polypeptide 2 3 4 5
  • Kelch-Like Family Member 27 2 3
  • Kelch-Like Protein 27 3 4
  • KLHL27 3 4
  • Actin-Binding Protein IPP 3

External Ids for IPP Gene

Previous GeneCards Identifiers for IPP Gene

  • GC01M045891
  • GC01M045164
  • GC01M045594
  • GC01M045577
  • GC01M045829
  • GC01M046159
  • GC01M044271

Summaries for IPP Gene

Entrez Gene Summary for IPP Gene

  • The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPP Gene

IPP (Intracisternal A Particle-Promoted Polypeptide) is a Protein Coding gene. Diseases associated with IPP include Cardiac Tamponade and Peroneal Nerve Paralysis. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL10.

UniProtKB/Swiss-Prot for IPP Gene

  • May play a role in organizing the actin cytoskeleton.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPP Gene

Genomics for IPP Gene

Regulatory Elements for IPP Gene

Enhancers for IPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F046519 1.6 FANTOM5 Ensembl ENCODE 12.8 -770.8 -770782 3.6 HDGF PKNOX1 ARNT CREB3L1 SIN3A CBX5 FOS KLF13 CEBPZ REST EFCAB14-AS1 DMBX1 IPP KNCN EFCAB14 TEX38 ATPAF1 NSUN4 MKNK1 CYP4Z1
GH01F046246 1.4 FANTOM5 ENCODE 12.9 -497.2 -497197 3.1 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 TOE1 GPBP1L1 EFCAB14-AS1 RPL7AP16 IPP RPS15AP10 TMEM69 NSUN4 RAD54L GC01M046227
GH01F045801 1.4 FANTOM5 ENCODE 12 -53.0 -52952 3.6 HDGF CREB3L1 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 FOS SP3 JUNB CCDC163 MAST2 IPP TMA16P2
GH01F044985 1.2 ENCODE 12.8 +764.4 764428 2.0 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TOE1 GPBP1L1 RPS8 TMA16P2 RPL7AP16 UROD IPP RPS15AP10 TMEM69 BTBD19
GH01F045541 1.7 FANTOM5 Ensembl ENCODE 8.4 +206.9 206913 5.0 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B DMAP1 ZNF48 YY1 ELK1 CCDC163 PRDX1 IPP AKR1A1 MMACHC TESK2 GPBP1L1 TOE1 GC01P045551 HMGB1P48
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IPP on UCSC Golden Path with GeneCards custom track

Promoters for IPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076906 113 1801 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for IPP Gene

Chromosome:
1
Start:
45,694,324 bp from pter
End:
45,750,813 bp from pter
Size:
56,490 bases
Orientation:
Minus strand

Genomic View for IPP Gene

Genes around IPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPP Gene

Proteins for IPP Gene

  • Protein details for IPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y573-IPP_HUMAN
    Recommended name:
    Actin-binding protein IPP
    Protein Accession:
    Q9Y573
    Secondary Accessions:
    • A2A6V4
    • D3DQ11
    • Q8N5C3

    Protein attributes for IPP Gene

    Size:
    584 amino acids
    Molecular mass:
    65261 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPP Gene

Post-translational modifications for IPP Gene

  • Ubiquitination at Lys 238 and Lys 279
  • Modification sites at PhosphoSitePlus

Other Protein References for IPP Gene

No data available for DME Specific Peptides for IPP Gene

Domains & Families for IPP Gene

Gene Families for IPP Gene

Suggested Antigen Peptide Sequences for IPP Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y573

UniProtKB/Swiss-Prot:

IPP_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with IPP: view

Function for IPP Gene

Molecular function for IPP Gene

GENATLAS Biochemistry:
intracisternal A-particle (IAP)-promoted,placenta,mouse homolog,Kelch family member
UniProtKB/Swiss-Prot Function:
May play a role in organizing the actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with IPP: view
genes like me logo Genes that share phenotypes with IPP: view

Animal Models for IPP Gene

MGI Knock Outs for IPP:
  • Ipp tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for IPP Gene

miRTarBase miRNAs that target IPP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPP Gene

Localization for IPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPP Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPP gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton TAS 10072760
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with IPP: view

Pathways & Interactions for IPP Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with IPP: view

No data available for Pathways by source and SIGNOR curated interactions for IPP Gene

Transcripts for IPP Gene

Unigene Clusters for IPP Gene

Intracisternal A particle-promoted polypeptide:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPP Gene

No ASD Table

Relevant External Links for IPP Gene

GeneLoc Exon Structure for
IPP
ECgene alternative splicing isoforms for
IPP

Expression for IPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPP Gene

Protein differential expression in normal tissues from HIPED for IPP Gene

This gene is overexpressed in Heart (50.1) and Placenta (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPP Gene



Protein tissue co-expression partners for IPP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPP Gene:

IPP

SOURCE GeneReport for Unigene cluster for IPP Gene:

Hs.744252
genes like me logo Genes that share expression patterns with IPP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPP Gene

Orthologs for IPP Gene

This gene was present in the common ancestor of animals.

Orthologs for IPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPP 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia IPP 34 35
  • 94.92 (n)
cow
(Bos Taurus)
Mammalia IPP 34 35
  • 93.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IPP 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipp 34 16 35
  • 89.5 (n)
rat
(Rattus norvegicus)
Mammalia Ipp 34
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia IPP 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPP 34 35
  • 75.59 (n)
lizard
(Anolis carolinensis)
Reptilia IPP 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipp 34
  • 70.43 (n)
zebrafish
(Danio rerio)
Actinopterygii ipp 34 35
  • 67.69 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2413 34
fruit fly
(Drosophila melanogaster)
Insecta CG9426 36 34 35
  • 48.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009913 34
  • 47.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
CSA.6551 35
  • 30 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
CSA.2774 35
  • 27 (a)
OneToMany
-- 35
  • 25 (a)
OneToMany
-- 35
  • 25 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
-- 35
  • 22 (a)
OneToMany
Species where no ortholog for IPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPP Gene

ENSEMBL:
Gene Tree for IPP (if available)
TreeFam:
Gene Tree for IPP (if available)

Paralogs for IPP Gene

Paralogs for IPP Gene

(16) SIMAP similar genes for IPP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IPP: view

Variants for IPP Gene

Sequence variations from dbSNP and Humsavar for IPP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10690484 -- 45,751,075(+) CTGAG(-/TC)TGCAT nc-transcript-variant, upstream-variant-2KB
rs1071839 -- 45,694,137(+) AGTTT(A/T)AAAAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10749856 -- 45,699,174(+) TCATC(A/T)AGCAA intron-variant, utr-variant-3-prime
rs10789471 -- 45,749,947(+) ACTTG(A/G)GAGGC intron-variant, upstream-variant-2KB
rs10890344 -- 45,700,418(+) CTCAG(C/T)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPP Gene

Variant ID Type Subtype PubMed ID
nsv945922 CNV duplication 23825009
nsv436781 CNV insertion 17901297
nsv159558 CNV deletion 16902084
nsv1149283 CNV deletion 26484159
nsv1113112 CNV deletion 24896259
nsv1014128 CNV gain 25217958
esv4646 CNV loss 18987735
esv3893512 CNV gain 25118596
esv3585916 CNV gain 21293372
esv3585915 CNV gain 21293372
esv3585914 CNV gain 21293372
esv3577471 CNV gain 25503493
esv3577360 CNV gain 25503493
esv3561582 CNV deletion 23714750
esv2747830 CNV deletion 23290073
esv2023284 CNV deletion 18987734
esv1730955 CNV deletion 17803354
esv1007960 CNV insertion 20482838
dgv159n100 CNV gain 25217958

Variation tolerance for IPP Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPP Gene

Disorders for IPP Gene

MalaCards: The human disease database

(2) MalaCards diseases for IPP Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiac tamponade
  • pericardial tamponade
peroneal nerve paralysis
  • peroneal nerve palsy
- elite association - COSMIC cancer census association via MalaCards
Search IPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for IPP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPP
genes like me logo Genes that share disorders with IPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPP Gene

Publications for IPP Gene

  1. The IPP gene is assigned to human chromosome 1p32-1p22. (PMID: 8432546) Chang-Yeh A. … Huang R.C. (Genomics 1993) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. (PMID: 10072760) Kim I.F. … Huang R.C. (Gene 1999) 3 4 64
  4. Cell lineage-specific expression of the MIPP gene. (PMID: 1905535) Mold D.E. … Huang R.C. (Biochem. Biophys. Res. Commun. 1991) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for IPP Gene

Sources for IPP Gene

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