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Aliases for IPO9 Gene

Aliases for IPO9 Gene

  • Importin 9 2 3 5
  • Ran-Binding Protein 9 3 4
  • RanBP9 3 4
  • Imp9 3 4
  • Importin-9 3
  • KIAA1192 4

External Ids for IPO9 Gene

Previous GeneCards Identifiers for IPO9 Gene

  • GC01P197232
  • GC01P198264
  • GC01P199086
  • GC01P198529
  • GC01P200064
  • GC01P201798
  • GC01P172964

Summaries for IPO9 Gene

GeneCards Summary for IPO9 Gene

IPO9 (Importin 9) is a Protein Coding gene. Diseases associated with IPO9 include Atypical Lipomatous Tumor. GO annotations related to this gene include binding and protein transporter activity.

UniProtKB/Swiss-Prot for IPO9 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

Gene Wiki entry for IPO9 Gene

Additional gene information for IPO9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO9 Gene

Genomics for IPO9 Gene

Regulatory Elements for IPO9 Gene

Enhancers for IPO9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H201435 1.6 Ensembl ENCODE dbSUPER 61.9 -393.2 -393173 0 HDGF ARNT ZFP64 SIN3A FEZF1 ZNF2 ZBTB7B ZNF302 ZNF207 ZNF143 IPO9 IPO9-AS1 ENSG00000224818 DDX59 ENSG00000235121 CAMSAP2 RNPEP ENSG00000273478 PHLDA3 LAD1
GH01H201498 1.8 FANTOM5 ENCODE dbSUPER 38.3 -326.0 -326001 10 PKNOX1 FOXA2 ZFP64 SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF143 IPO9-AS1 IPO9 ELF3-AS1 RNPEP ENSG00000273478 RPS10P7 NAV1 DDX59 ENSG00000235121 LMOD1
GH01H201550 1.9 FANTOM5 Ensembl ENCODE dbSUPER 31.3 -276.0 -276036 4 PKNOX1 ATF1 ARNT ZNF121 ZNF766 ELK1 ZNF416 FOS ATF7 SP3 IPO9 RNPEP ENSG00000273478 IPO9-AS1 DDX59 ELF3-AS1 RPS27P8 NAV1 LMOD1 GC01M201547
GH01H202157 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.8 +333.0 332972 8 HDGF PKNOX1 ARNT YBX1 YY1 ZNF766 CBX5 ZNF143 REST SMARCB1 IPO9 KDM5B RNPEP ENSG00000273478 IPO9-AS1 PTPN7 CYB5R1 PTPRVP HNRNPA1P59 ENSG00000235121
GH01H202233 1.5 Ensembl ENCODE dbSUPER 28 +406.1 406087 3 HDGF ARNT SIN3A ZNF2 GLIS2 ZNF143 ZNF548 ATF7 FOS DEK IPO9 IPO9-AS1 LGR6 KDM5B PTPRVP GC01M202216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IPO9 on UCSC Golden Path with GeneCards custom track

Promoters for IPO9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018194 559 1401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Location for IPO9 Gene

Chromosome:
1
Start:
201,829,141 bp from pter
End:
201,884,294 bp from pter
Size:
55,154 bases
Orientation:
Plus strand

Genomic View for IPO9 Gene

Genes around IPO9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO9 Gene

Proteins for IPO9 Gene

  • Protein details for IPO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P70-IPO9_HUMAN
    Recommended name:
    Importin-9
    Protein Accession:
    Q96P70
    Secondary Accessions:
    • B1ASV5
    • Q8N1Y1
    • Q8N3I2
    • Q8NCG9
    • Q96SU6
    • Q9NW01
    • Q9P0A8
    • Q9ULM8

    Protein attributes for IPO9 Gene

    Size:
    1041 amino acids
    Molecular mass:
    115963 Da
    Quaternary structure:
    • Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.
    SequenceCaution:
    • Sequence=AAF28951.1; Type=Frameshift; Positions=982; Evidence={ECO:0000305}; Sequence=BAA86506.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91588.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55181.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11173.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IPO9 Gene

Post-translational modifications for IPO9 Gene

  • Ubiquitination at posLast=773773, posLast=865865, and isoforms=884
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPO9 Gene

Domains & Families for IPO9 Gene

Gene Families for IPO9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for IPO9 Gene

Suggested Antigen Peptide Sequences for IPO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P70

UniProtKB/Swiss-Prot:

IPO9_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO9: view

Function for IPO9 Gene

Molecular function for IPO9 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

Phenotypes From GWAS Catalog for IPO9 Gene

Gene Ontology (GO) - Molecular Function for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11823430
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IDA 11823430
GO:0042393 histone binding ISS --
genes like me logo Genes that share ontologies with IPO9: view
genes like me logo Genes that share phenotypes with IPO9: view

Animal Model Products

CRISPR Products

miRNA for IPO9 Gene

miRTarBase miRNAs that target IPO9

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IPO9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO9 Gene

Localization for IPO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO9 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA --
GO:0005737 cytoplasm IEA,IDA 11823430
GO:0005829 cytosol IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IPO9: view

Pathways & Interactions for IPO9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus NAS 11823430
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with IPO9: view

No data available for Pathways by source and SIGNOR curated interactions for IPO9 Gene

Drugs & Compounds for IPO9 Gene

(2) Drugs for IPO9 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO9: view

Transcripts for IPO9 Gene

Unigene Clusters for IPO9 Gene

Importin 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IPO9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IPO9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:

ExUns: 19b ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26a · 26b
SP1: - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for IPO9 Gene

GeneLoc Exon Structure for
IPO9
ECgene alternative splicing isoforms for
IPO9

Expression for IPO9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPO9 Gene

Protein differential expression in normal tissues from HIPED for IPO9 Gene

This gene is overexpressed in Bone (47.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPO9 Gene



Protein tissue co-expression partners for IPO9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPO9 Gene:

IPO9

SOURCE GeneReport for Unigene cluster for IPO9 Gene:

Hs.596014

Evidence on tissue expression from TISSUES for IPO9 Gene

  • Nervous system(4.7)
  • Blood(4.2)
  • Lung(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with IPO9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO9 Gene

Orthologs for IPO9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO9 33 34
  • 99.94 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO9 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO9 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO9 33 34
  • 94.26 (n)
mouse
(Mus musculus)
Mammalia Ipo9 33 16 34
  • 91.68 (n)
rat
(Rattus norvegicus)
Mammalia Ipo9 33
  • 91.64 (n)
cow
(Bos Taurus)
Mammalia IPO9 33 34
  • 85.58 (n)
chicken
(Gallus gallus)
Aves IPO9 33 34
  • 81.56 (n)
lizard
(Anolis carolinensis)
Reptilia IPO9 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo9 33
  • 75.94 (n)
Str.16170 33
zebrafish
(Danio rerio)
Actinopterygii ipo9 33 34
  • 76.35 (n)
wufc23d12 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011156 33
  • 50.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp9 33 34
  • 49.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP114 34 36
  • 20 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26170 33
  • 42.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.748 34
  • 47 (a)
OneToOne
Species where no ortholog for IPO9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO9 Gene

ENSEMBL:
Gene Tree for IPO9 (if available)
TreeFam:
Gene Tree for IPO9 (if available)

Paralogs for IPO9 Gene

No data available for Paralogs for IPO9 Gene

Variants for IPO9 Gene

Sequence variations from dbSNP and Humsavar for IPO9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000094957 -- 201,827,513(+) CCTGT(A/G)GTTCT intron-variant, upstream-variant-2KB
rs1000135102 -- 201,871,638(+) TCCAC(C/G)CACTT intron-variant
rs1000153396 -- 201,831,987(+) ACCTC(C/T)GCCTC intron-variant
rs1000156459 -- 201,856,210(+) AAGCA(A/G)TCCAC intron-variant
rs1000187189 -- 201,873,814(+) AGAAG(C/T)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO9 Gene

Variant ID Type Subtype PubMed ID
esv2667793 CNV deletion 23128226
esv3588575 CNV loss 21293372
nsv1116492 OTHER inversion 24896259
nsv159766 CNV insertion 16902084

Variation tolerance for IPO9 Gene

Residual Variation Intolerance Score: 6.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO9 Gene

Human Gene Mutation Database (HGMD)
IPO9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO9 Gene

Disorders for IPO9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPO9 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
atypical lipomatous tumor
  • liposarcoma, well differentiated
- elite association - COSMIC cancer census association via MalaCards
Search IPO9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IPO9

Genetic Association Database (GAD)
IPO9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO9
genes like me logo Genes that share disorders with IPO9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO9 Gene

Publications for IPO9 Gene

  1. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 2 3 4 60
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PMID: 12670497) Lubert EJ … Sarge KD (Biochemical and biophysical research communications 2003) 3 4 60

Products for IPO9 Gene

Sources for IPO9 Gene

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