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Aliases for IPO9 Gene

Aliases for IPO9 Gene

  • Importin 9 2 3
  • Ran-Binding Protein 9 3 4
  • RanBP9 3 4
  • Imp9 3 4
  • Importin-9 3
  • KIAA1192 4

External Ids for IPO9 Gene

Previous GeneCards Identifiers for IPO9 Gene

  • GC01P197232
  • GC01P198264
  • GC01P199086
  • GC01P198529
  • GC01P200064
  • GC01P201798
  • GC01P172964

Summaries for IPO9 Gene

GeneCards Summary for IPO9 Gene

IPO9 (Importin 9) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include protein transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for IPO9 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

Gene Wiki entry for IPO9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO9 Gene

Genomics for IPO9 Gene

Regulatory Elements for IPO9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IPO9 Gene

Start:
201,829,141 bp from pter
End:
201,884,294 bp from pter
Size:
55,154 bases
Orientation:
Plus strand

Genomic View for IPO9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IPO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO9 Gene

Proteins for IPO9 Gene

  • Protein details for IPO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P70-IPO9_HUMAN
    Recommended name:
    Importin-9
    Protein Accession:
    Q96P70
    Secondary Accessions:
    • B1ASV5
    • Q8N1Y1
    • Q8N3I2
    • Q8NCG9
    • Q96SU6
    • Q9NW01
    • Q9P0A8
    • Q9ULM8

    Protein attributes for IPO9 Gene

    Size:
    1041 amino acids
    Molecular mass:
    115963 Da
    Quaternary structure:
    • Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.
    SequenceCaution:
    • Sequence=AAF28951.1; Type=Frameshift; Positions=982; Evidence={ECO:0000305}; Sequence=BAA86506.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91588.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55181.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11173.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IPO9 Gene

Proteomics data for IPO9 Gene at MOPED

Post-translational modifications for IPO9 Gene

  • Ubiquitination at Lys773, Lys865, and Lys884
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPO9 Gene

Domains for IPO9 Gene

Gene Families for IPO9 Gene

HGNC:
  • IPO :Importins

Protein Domains for IPO9 Gene

Suggested Antigen Peptide Sequences for IPO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P70

UniProtKB/Swiss-Prot:

IPO9_HUMAN :
  • Q96P70
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO9: view

Function for IPO9 Gene

Molecular function for IPO9 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

Gene Ontology (GO) - Molecular Function for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 11823430
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IDA 11823430
GO:0042393 histone binding ISS --
genes like me logo Genes that share ontologies with IPO9: view

Phenotypes for IPO9 Gene

MGI mutant phenotypes for IPO9:
inferred from 1 alleles
GenomeRNAi human phenotypes for IPO9:
genes like me logo Genes that share phenotypes with IPO9: view

Animal Model Products

miRNA for IPO9 Gene

miRTarBase miRNAs that target IPO9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IPO9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IPO9 Gene

Localization for IPO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO9 Gene COMPARTMENTS Subcellular localization image for IPO9 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 11823430
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IPO9: view

Pathways for IPO9 Gene

genes like me logo Genes that share pathways with IPO9: view

Pathways by source for IPO9 Gene

Gene Ontology (GO) - Biological Process for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus NAS 11823430
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with IPO9: view

Compounds for IPO9 Gene

(1) HMDB Compounds for IPO9 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with IPO9: view

Transcripts for IPO9 Gene

Unigene Clusters for IPO9 Gene

Importin 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IPO9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IPO9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:

ExUns: 19b ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26a · 26b
SP1: - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for IPO9 Gene

GeneLoc Exon Structure for
IPO9
ECgene alternative splicing isoforms for
IPO9

Expression for IPO9 Gene

mRNA expression in normal human tissues for IPO9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO9 Gene

SOURCE GeneReport for Unigene cluster for IPO9 Gene Hs.596014

genes like me logo Genes that share expressions with IPO9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPO9 Gene

Orthologs for IPO9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO9 35
  • 99.94 (n)
  • 100 (a)
IPO9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IPO9 35
  • 85.58 (n)
  • 95.95 (a)
IPO9 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO9 35
  • 94.26 (n)
  • 99.6 (a)
IPO9 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo9 35
  • 91.68 (n)
  • 98.93 (a)
Ipo9 16
Ipo9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IPO9 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO9 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo9 35
  • 91.64 (n)
  • 99.04 (a)
chicken
(Gallus gallus)
Aves IPO9 35
  • 81.56 (n)
  • 94.62 (a)
IPO9 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO9 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo9 35
  • 75.94 (n)
  • 88.09 (a)
Str.16170 35
zebrafish
(Danio rerio)
Actinopterygii ipo9 35
  • 76.35 (n)
  • 86.55 (a)
ipo9 36
  • 85 (a)
OneToOne
wufc23d12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011156 35
  • 50.5 (n)
  • 40.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp9 35
  • 49.18 (n)
  • 39.06 (a)
Ranbp9 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP114 36
  • 20 (a)
OneToOne
KAP114 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26170 35
  • 42.88 (n)
  • 28.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.748 36
  • 47 (a)
OneToOne
Species with no ortholog for IPO9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO9 Gene

ENSEMBL:
Gene Tree for IPO9 (if available)
TreeFam:
Gene Tree for IPO9 (if available)

Paralogs for IPO9 Gene

No data available for Paralogs for IPO9 Gene

Variants for IPO9 Gene

Sequence variations from dbSNP and Humsavar for IPO9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8024 -- 201,876,447(+) ACAGA(A/C)CTATC utr-variant-3-prime
rs903678 -- 201,840,790(+) TGTCT(A/G)TAATA intron-variant
rs950114 -- 201,871,082(+) TCTTA(C/T)CTGAC intron-variant
rs1043823 -- 201,876,304(+) CTCCC(C/T)GACTC utr-variant-3-prime
rs1063139 -- 201,880,386(+) GATGA(C/G)TCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IPO9 Gene

Variant ID Type Subtype PubMed ID
esv2667793 CNV Deletion 23128226
nsv159766 CNV Insertion 16902084

Relevant External Links for IPO9 Gene

HapMap Linkage Disequilibrium report
IPO9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO9 Gene

Disorders for IPO9 Gene

Relevant External Links for IPO9

Genetic Association Database (GAD)
IPO9
genes like me logo Genes that share disorders with IPO9: view

No data available for UniProtKB/Swiss-Prot for IPO9 Gene

Publications for IPO9 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Multiple pathways contribute to nuclear import of core histones. (PMID: 11493596) MA1hlhAousser P. … Kutay U. (EMBO Rep. 2001) 3 23
  5. Interaction between protein phosphatase 2A and members of the importin beta superfamily. (PMID: 12670497) Lubert E.J. … Sarge K.D. (Biochem. Biophys. Res. Commun. 2003) 3 4

Products for IPO9 Gene

Sources for IPO9 Gene

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