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Aliases for IPO9 Gene

Aliases for IPO9 Gene

  • Importin 9 2 3 5
  • Ran-Binding Protein 9 3 4
  • RanBP9 3 4
  • Imp9 3 4
  • KIAA1192 4

External Ids for IPO9 Gene

Previous GeneCards Identifiers for IPO9 Gene

  • GC01P197232
  • GC01P198264
  • GC01P199086
  • GC01P198529
  • GC01P200064
  • GC01P201798
  • GC01P172964

Summaries for IPO9 Gene

GeneCards Summary for IPO9 Gene

IPO9 (Importin 9) is a Protein Coding gene. Diseases associated with IPO9 include atypical lipomatous tumor. Among its related pathways are Developmental Biology and BDNF signaling pathway. GO annotations related to this gene include binding and protein transporter activity.

UniProtKB/Swiss-Prot for IPO9 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

Gene Wiki entry for IPO9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO9 Gene

Genomics for IPO9 Gene

Regulatory Elements for IPO9 Gene

Promoters for IPO9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IPO9 on UCSC Golden Path with GeneCards custom track

Genomic Location for IPO9 Gene

Chromosome:
1
Start:
201,829,141 bp from pter
End:
201,884,294 bp from pter
Size:
55,154 bases
Orientation:
Plus strand

Genomic View for IPO9 Gene

Genes around IPO9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO9 Gene

Proteins for IPO9 Gene

  • Protein details for IPO9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P70-IPO9_HUMAN
    Recommended name:
    Importin-9
    Protein Accession:
    Q96P70
    Secondary Accessions:
    • B1ASV5
    • Q8N1Y1
    • Q8N3I2
    • Q8NCG9
    • Q96SU6
    • Q9NW01
    • Q9P0A8
    • Q9ULM8

    Protein attributes for IPO9 Gene

    Size:
    1041 amino acids
    Molecular mass:
    115963 Da
    Quaternary structure:
    • Binds with high affinity to RPS7 and RPL18A. The binding is coupled to RanGTP cycles. May bind H2A, H3, H4 histones (By similarity), RPL4 and RPL6 with low affinity. Interacts with PPP2R1A and PPP2R1B.
    SequenceCaution:
    • Sequence=AAF28951.1; Type=Frameshift; Positions=982; Evidence={ECO:0000305}; Sequence=BAA86506.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91588.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55181.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11173.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IPO9 Gene

Proteomics data for IPO9 Gene at MOPED

Post-translational modifications for IPO9 Gene

  • Ubiquitination at Lys 773, Lys 865, and Lys 884
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPO9 Gene

Domains & Families for IPO9 Gene

Gene Families for IPO9 Gene

Protein Domains for IPO9 Gene

Suggested Antigen Peptide Sequences for IPO9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P70

UniProtKB/Swiss-Prot:

IPO9_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO9: view

Function for IPO9 Gene

Molecular function for IPO9 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.

Gene Ontology (GO) - Molecular Function for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042393 histone binding ISS --
genes like me logo Genes that share ontologies with IPO9: view
genes like me logo Genes that share phenotypes with IPO9: view

Animal Model Products

miRNA for IPO9 Gene

miRTarBase miRNAs that target IPO9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO9 Gene

Localization for IPO9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO9 Gene COMPARTMENTS Subcellular localization image for IPO9 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for IPO9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with IPO9: view

Pathways & Interactions for IPO9 Gene

genes like me logo Genes that share pathways with IPO9: view

Pathways by source for IPO9 Gene

Gene Ontology (GO) - Biological Process for IPO9 Gene

None

No data available for SIGNOR curated interactions for IPO9 Gene

Drugs & Compounds for IPO9 Gene

(2) Drugs for IPO9 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO9: view

Transcripts for IPO9 Gene

Unigene Clusters for IPO9 Gene

Importin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a ·
SP1: - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:

ExUns: 19b ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26a · 26b
SP1: - -
SP2:
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for IPO9 Gene

GeneLoc Exon Structure for
IPO9
ECgene alternative splicing isoforms for
IPO9

Expression for IPO9 Gene

mRNA expression in normal human tissues for IPO9 Gene

Protein differential expression in normal tissues from HIPED for IPO9 Gene

This gene is overexpressed in Bone (47.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO9 Gene



SOURCE GeneReport for Unigene cluster for IPO9 Gene Hs.596014

genes like me logo Genes that share expression patterns with IPO9: view

Protein tissue co-expression partners for IPO9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPO9 Gene

Orthologs for IPO9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IPO9 35
  • 85.58 (n)
  • 95.95 (a)
IPO9 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO9 35
  • 94.26 (n)
  • 99.6 (a)
IPO9 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo9 35
  • 91.68 (n)
  • 98.93 (a)
Ipo9 16
Ipo9 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IPO9 35
  • 99.94 (n)
  • 100 (a)
IPO9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo9 35
  • 91.64 (n)
  • 99.04 (a)
oppossum
(Monodelphis domestica)
Mammalia IPO9 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO9 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPO9 35
  • 81.56 (n)
  • 94.62 (a)
IPO9 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO9 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo9 35
  • 75.94 (n)
  • 88.09 (a)
Str.16170 35
zebrafish
(Danio rerio)
Actinopterygii ipo9 35
  • 76.35 (n)
  • 86.55 (a)
wufc23d12 35
ipo9 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011156 35
  • 50.5 (n)
  • 40.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp9 35
  • 49.18 (n)
  • 39.06 (a)
Ranbp9 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP114 36
  • 20 (a)
OneToOne
KAP114 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26170 35
  • 42.88 (n)
  • 28.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.748 36
  • 47 (a)
OneToOne
Species with no ortholog for IPO9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO9 Gene

ENSEMBL:
Gene Tree for IPO9 (if available)
TreeFam:
Gene Tree for IPO9 (if available)

Paralogs for IPO9 Gene

No data available for Paralogs for IPO9 Gene

Variants for IPO9 Gene

Sequence variations from dbSNP and Humsavar for IPO9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs8024 -- 201,876,447(+) ACAGA(A/C)CTATC utr-variant-3-prime
rs903678 -- 201,840,790(+) TGTCT(A/G)TAATA intron-variant
rs950114 -- 201,871,082(+) TCTTA(C/T)CTGAC intron-variant
rs1063139 -- 201,880,386(+) GATGA(C/G)TCCTC utr-variant-3-prime
rs1043823 -- 201,876,304(+) CTCCC(C/T)GACTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IPO9 Gene

Variant ID Type Subtype PubMed ID
esv2667793 CNV Deletion 23128226
nsv159766 CNV Insertion 16902084

Variation tolerance for IPO9 Gene

Residual Variation Intolerance Score: 6.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO9 Gene

HapMap Linkage Disequilibrium report
IPO9
Human Gene Mutation Database (HGMD)
IPO9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO9 Gene

Disorders for IPO9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPO9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
atypical lipomatous tumor
  • pleomorphic lipoma
- elite association - COSMIC cancer census association via MalaCards
Search IPO9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IPO9

Genetic Association Database (GAD)
IPO9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO9
genes like me logo Genes that share disorders with IPO9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO9 Gene

Publications for IPO9 Gene

  1. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 2 3 4 67
  2. Multiple pathways contribute to nuclear import of core histones. (PMID: 11493596) MA1hlhAousser P. … Kutay U. (EMBO Rep. 2001) 3 23
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for IPO9 Gene

Sources for IPO9 Gene

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