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Aliases for IPO8 Gene

Aliases for IPO8 Gene

  • Importin 8 2 3 5
  • RAN Binding Protein 8 2 3
  • Ran-Binding Protein 8 3 4
  • RANBP8 3 4
  • Imp8 3 4

External Ids for IPO8 Gene

Previous HGNC Symbols for IPO8 Gene

  • RANBP8

Previous GeneCards Identifiers for IPO8 Gene

  • GC12M030805
  • GC12M030682
  • GC12M030673
  • GC12M030675
  • GC12M030547

Summaries for IPO8 Gene

Entrez Gene Summary for IPO8 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IPO8 Gene

IPO8 (Importin 8) is a Protein Coding gene. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is IPO7.

UniProtKB/Swiss-Prot for IPO8 Gene

  • Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO8 Gene

Genomics for IPO8 Gene

Regulatory Elements for IPO8 Gene

Promoters for IPO8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IPO8 on UCSC Golden Path with GeneCards custom track

Genomic Location for IPO8 Gene

Chromosome:
12
Start:
30,628,981 bp from pter
End:
30,695,995 bp from pter
Size:
67,015 bases
Orientation:
Minus strand

Genomic View for IPO8 Gene

Genes around IPO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO8 Gene

Proteins for IPO8 Gene

  • Protein details for IPO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15397-IPO8_HUMAN
    Recommended name:
    Importin-8
    Protein Accession:
    O15397
    Secondary Accessions:
    • B7Z7M3

    Protein attributes for IPO8 Gene

    Size:
    1037 amino acids
    Molecular mass:
    119938 Da
    Quaternary structure:
    • Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes.

    Alternative splice isoforms for IPO8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO8 Gene

Proteomics data for IPO8 Gene at MOPED

Post-translational modifications for IPO8 Gene

  • Ubiquitination at Lys 510
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IPO8 Gene

Domains & Families for IPO8 Gene

Gene Families for IPO8 Gene

Protein Domains for IPO8 Gene

Suggested Antigen Peptide Sequences for IPO8 Gene

Graphical View of Domain Structure for InterPro Entry

O15397

UniProtKB/Swiss-Prot:

IPO8_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO8: view

Function for IPO8 Gene

Molecular function for IPO8 Gene

UniProtKB/Swiss-Prot Function:
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.
genes like me logo Genes that share phenotypes with IPO8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO8 Gene

Localization for IPO8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO8 Gene COMPARTMENTS Subcellular localization image for IPO8 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with IPO8: view

Pathways & Interactions for IPO8 Gene

genes like me logo Genes that share pathways with IPO8: view

Pathways by source for IPO8 Gene

Gene Ontology (GO) - Biological Process for IPO8 Gene

None

No data available for SIGNOR curated interactions for IPO8 Gene

Drugs & Compounds for IPO8 Gene

(2) Drugs for IPO8 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO8: view

Transcripts for IPO8 Gene

Unigene Clusters for IPO8 Gene

Importin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26a · 26b
SP1:
SP2:
SP3:

Relevant External Links for IPO8 Gene

GeneLoc Exon Structure for
IPO8
ECgene alternative splicing isoforms for
IPO8

Expression for IPO8 Gene

mRNA expression in normal human tissues for IPO8 Gene

Protein differential expression in normal tissues from HIPED for IPO8 Gene

This gene is overexpressed in Bone (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO8 Gene



SOURCE GeneReport for Unigene cluster for IPO8 Gene Hs.505136

genes like me logo Genes that share expression patterns with IPO8: view

Protein tissue co-expression partners for IPO8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPO8 Gene

Orthologs for IPO8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPO8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IPO8 35
  • 93.44 (n)
  • 97.01 (a)
IPO8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO8 35
  • 93.44 (n)
  • 97.4 (a)
IPO8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo8 35
  • 86.12 (n)
  • 92.37 (a)
Ipo8 16
Ipo8 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IPO8 35
  • 99.65 (n)
  • 99.81 (a)
IPO8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686774 35
  • 82.29 (n)
  • 89.12 (a)
oppossum
(Monodelphis domestica)
Mammalia IPO8 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO8 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPO8 35
  • 79.99 (n)
  • 87 (a)
IPO8 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO8 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo8 35
  • 70.29 (n)
  • 77.75 (a)
zebrafish
(Danio rerio)
Actinopterygii ipo8 35
  • 68.49 (n)
  • 72.54 (a)
ipo8 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta msk 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD5 36
  • 21 (a)
ManyToMany
SXM1 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3218 36
  • 49 (a)
OneToMany
Species with no ortholog for IPO8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO8 Gene

ENSEMBL:
Gene Tree for IPO8 (if available)
TreeFam:
Gene Tree for IPO8 (if available)

Paralogs for IPO8 Gene

Paralogs for IPO8 Gene

(1) SIMAP similar genes for IPO8 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IPO8 Gene

genes like me logo Genes that share paralogs with IPO8: view

Variants for IPO8 Gene

Sequence variations from dbSNP and Humsavar for IPO8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1054423 - 30,695,632(-) ACCGG(A/G/T)TCATC upstream-variant-2KB, reference, missense
rs34119940 - 30,656,714(+) ATCAA(C/T)GATCC reference, missense
rs7325 -- 30,629,468(-) CCCTC(A/G)TGCAT utr-variant-3-prime
rs7326 -- 30,629,367(-) TCTGC(C/T)CCTCC utr-variant-3-prime
rs7327 -- 30,629,142(-) AAGAG(A/G)TATTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IPO8 Gene

Variant ID Type Subtype PubMed ID
nsv832361 CNV Loss 17160897
nsv515645 CNV Loss 19592680

Variation tolerance for IPO8 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO8 Gene

HapMap Linkage Disequilibrium report
IPO8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO8 Gene

Disorders for IPO8 Gene

Relevant External Links for IPO8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO8

No disorders were found for IPO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO8 Gene

Publications for IPO8 Gene

  1. A novel class of RanGTP binding proteins. (PMID: 9214382) Goerlich D. … Izaurralde E. (J. Cell Biol. 1997) 2 3 4 67
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L. … Meister G. (Cell 2009) 3 23
  3. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PMID: 19014639) Nguewa P.A. … Calvo A. (BMC Mol. Biol. 2008) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IPO8 Gene

Sources for IPO8 Gene

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