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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPO8 Gene

protein-coding   GIFtS: 54
GCID: GC12M030682

Importin 8

(Previous name: RAN binding protein 8)
(Previous symbol: RANBP8)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Importin 81 2     imp82
RANBP81 2 3 5     importin-82
RAN Binding Protein 81 2     Imp83
Ran-Binding Protein 82 3     RanBP83

External Ids:    HGNC: 98531   Entrez Gene: 105262   Ensembl: ENSG000001337047   OMIM: 6056005   UniProtKB: O153973   

Export aliases for IPO8 gene to outside databases

Previous GC identifers: GC12M030805 GC12M030673 GC12M030675 GC12M030547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IPO8 Gene:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear
localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran
targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the
nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2010)

GeneCards Summary for IPO8 Gene: 
IPO8 (importin 8) is a protein-coding gene. Diseases associated with IPO8 include alcoholism. GO annotations related to this gene include protein transporter activity and Ran GTPase binding. An important paralog of this gene is IPO7.

UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
Function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor
or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is
thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import
substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is
re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear
import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between
the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPO8 gene promoter:
         GR   GR-beta   GR-alpha   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO8 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPO8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

IPO8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M030682:  view genomic region     (about GC identifiers)

Start:
30,781,915 bp from pter      End:
30,848,929 bp from pter
Size:
67,015 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397 (See protein sequence)
Recommended Name: Importin-8  
Size: 1037 amino acids; 119938 Da
Subunit: Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: B7Z7M3
Alternative splicing: 2 isoforms:  O15397-1   O15397-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IPO8: NX_O15397

Explore proteomics data for IPO8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15397

  • IPO8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IPO8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177924.1  NP_006381.2  

    ENSEMBL proteins: 
     ENSP00000256079   ENSP00000444520   ENSP00000446232   ENSP00000439556   ENSP00000440979  
     ENSP00000443789   ENSP00000439413   ENSP00000444050   ENSP00000446254  

    Human Recombinant Protein Products for IPO8: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IPO8 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005643nuclear pore ----
    GO:0005737cytoplasm IEA--

    IPO8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013713 Exportin/Importin_Cse1-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O15397

    ProtoNet protein and cluster: O15397

    1 Blocks protein domain: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
    Similarity: Belongs to the importin beta family
    Similarity: Contains 1 importin N-terminal domain


    IPO8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO8_HUMAN, O15397
    Function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor
    or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is
    thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import
    substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is
    re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear
    import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between
    the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17932509
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    IPO8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IPO8:
     G2 arrest  Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IPO8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IPO8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPO8 
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    SwitchGear 3'UTR luciferase reporter plasmidIPO8 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IPO8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/83 Interacting proteins for IPO8 (O153971, 2, 3 ENSP000002560794) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO3Q9H9G71, 2, 3, ENSP000003622874EBI-358808,EBI-2267883 MINT-6489217 I2D: score=2 STRING: ENSP00000362287
    EIF2C2Q9UKV81, 2, 3EBI-358808,EBI-528269 MINT-6489217 I2D: score=2 
    EIF2C3Q9H9G71, 2, 3EBI-358808,EBI-2267883 MINT-6489217 I2D: score=2 
    ATXN1P542532, 3, ENSP000002447694MINT-2868490 MINT-2868471 I2D: score=3 STRING: ENSP00000244769
    AGO1Q9UL181, 3, ENSP000003623004EBI-358808,EBI-527363 I2D: score=2 STRING: ENSP00000362300
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction TAS9214382

    IPO8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPO8

    1 HMDB Compound for IPO8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about IPO8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IPO8 gene (2 alternative transcripts): 
    NM_001190995.1  NM_006390.3  

    Unigene Cluster for IPO8:

    Importin 8
    Hs.505136  [show with all ESTs]
    Unigene Representative Sequence: NM_006390
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256079(uc010sjt.2 uc001rjd.3 uc001rje.1) ENST00000544829
    ENST00000535598 ENST00000542464 ENST00000535989 ENST00000540979 ENST00000543446
    ENST00000358724 ENST00000545077 ENST00000538338
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO8 (see all 45):
    hsa-miR-4307 hsa-miR-429 hsa-miR-218 hsa-miR-759 hsa-miR-3916 hsa-miR-124 hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidIPO8 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO8

    Additional mRNA sequence: 

    AK000201.1 AK130090.1 AK302260.1 U77494.1 

    9 DOTS entries:

    DT.100776146  DT.442549  DT.121120385  DT.91697936  DT.121120371  DT.121120375  DT.95371399  DT.97819589 
    DT.91912038 

    24/148 AceView cDNA sequences (see all 148):

    N40895 BG574795 AA620453 AW295358 BX480054 N91588 AA866048 AA343858 
    CA432065 Z43332 Z45833 AI160299 BU620791 F02755 BQ773798 BX953283 
    BM751103 BG035092 AU125897 CA427400 Z43133 AA047641 AA236954 AA027075 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IPO8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26a · 26b
    SP1:                  
    SP2:                  
    SP3:                  


    ECgene alternative splicing isoforms for IPO8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPO8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTTTTGA
    IPO8 Expression
    About this image


    See IPO8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPO8

    SOURCE GeneReport for Unigene cluster: Hs.505136
        SABiosciences Custom PCR Arrays for IPO8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IPO8 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo81 , 5 importin 81, 5 86.34(n)1
    92.82(a)1
      6 (78.57 cM)5
    3207271  NM_001081113.11  NP_001074582.11 
     1487706835 
    chicken
    (Gallus gallus)
    Aves IPO81 importin 8 80.24(n)
    87.22(a)
      418142  XM_416373.3  XP_416373.3 
    lizard
    (Anolis carolinensis)
    Reptilia IPO86
    Uncharacterized protein
    84(a)
    1 ↔ 1
    5(10868902-10917486)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX714249.12   -- 78.74(n)    BX714249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM083089.12   -- 71.89(n)    BM083089.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msk6
    moleskin
    48(a)
    1 → many
    3L(8109279-8114679)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NMD56
    SXM16
    Karyopherin, a carrier protein involved in nuclear...
    Nuclear transport factor (karyopherin) involved in...
    23(a)
    21(a)
    many ↔ many
    many ↔ many
    X(669522-672668)
    IV(1263324-1266158)


    ENSEMBL Gene Tree for IPO8 (if available)
    TreeFam Gene Tree for IPO8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPO8 gene
    IPO72  
    1 SIMAP similar gene for IPO8 using alignment to 8 protein entries:     IPO8_HUMAN (see all proteins):
    IPO7

    IPO8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IPO8
    PGOHUM00000259510


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1312 SNPs in IPO8 are shown (see all 1312)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73117111,2
    C,F--30781496(+) gtttgT/Cgtaag 2 -- ds50012Minor allele frequency- C:0.05WA NA 238
    rs1869698201,2
    C--30781528(+) AATAAC/TAAAAT 2 -- ds50010--------
    rs1922333171,2
    --30781776(+) CTGTTC/TCTGAT 2 -- ds50010--------
    rs23522101,2
    C,F,O,H--30781829(+) AGGTCC/ACCAGG 2 -- ds500128Minor allele frequency- A:0.39NS EA NA WA CSA 2492
    rs64879231,2
    C,F,A,H--30781912(+) CACAAG/AAGTTC 2 -- ds500134Minor allele frequency- A:0.44NA NS EA WA CSA 2921
    rs788514291,2
    C,F--30781939(+) GTCCGC/TATTTT 2 -- ut311Minor allele frequency- T:0.02WA 118
    rs1858177561,2
    --30782058(+) AGATAA/GGGTAA 2 -- ut310--------
    rs73271,2
    C,F,O,A,H--30782076(-) AAGAGG/ATATTA 2 -- ut31 trp334Minor allele frequency- A:0.43MN NA NS EA WA CSA 3292
    rs1140976771,2
    C,F--30782249(+) TCTTTC/TGCTTC 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs73261,2
    C,F,A,H--30782301(-) TCTGCC/TCCTCC 2 -- ut31 trp318Minor allele frequency- T:0.45MN NS EA NA WA CSA 1164

    HapMap Linkage Disequilibrium report for IPO8 (30781915 - 30848929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IPO8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832361CNV Loss17160897
    nsv515645CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605600    OMIM disorders: --

    2 diseases for IPO8:    About MalaCards
    alcoholism    


    IPO8 for disorders           About GeneDecksing


    Export disorders for IPO8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPO8 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with IPO8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of RanGTP binding proteins. (PubMed id 9214382)1, 2, 3 Goerlich D.... Izaurralde E. (1997)
    2. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PubMed id 11682607)1, 2 Dean K.A.... Fried H.M. (2001)
    3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 9 Weinmann L.... Meister G. (2009)
    4. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PubMed id 19014639)1, 9 Nguewa P.A....Calvo A. (2008)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10526 HGNC: 9853 AceView: IPO8 Ensembl:ENSG00000133704 euGenes: HUgn10526
    ECgene: IPO8 H-InvDB: IPO8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPO8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IPO8 gene:
    Search GeneIP for patents involving IPO8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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