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Aliases for IPO8 Gene

Aliases for IPO8 Gene

  • Importin 8 2 3 5
  • RAN Binding Protein 8 2 3
  • Ran-Binding Protein 8 3 4
  • RANBP8 3 4
  • Imp8 3 4
  • Importin-8 3

External Ids for IPO8 Gene

Previous HGNC Symbols for IPO8 Gene

  • RANBP8

Previous GeneCards Identifiers for IPO8 Gene

  • GC12M030805
  • GC12M030682
  • GC12M030673
  • GC12M030675
  • GC12M030547

Summaries for IPO8 Gene

Entrez Gene Summary for IPO8 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IPO8 Gene

IPO8 (Importin 8) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. GO annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is IPO7.

UniProtKB/Swiss-Prot for IPO8 Gene

  • Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

Additional gene information for IPO8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO8 Gene

Genomics for IPO8 Gene

Regulatory Elements for IPO8 Gene

Enhancers for IPO8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H030694 1.1 ENCODE 55.1 +0.5 482 2 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 IPO8 DDX11 LOC105369720
GH12H031360 0.9 dbSUPER 62 -664.8 -664761 0 ZFP64 FEZF1 ZNF354C KLF7 ZNF202 ZNF654 ZNF680 ZC3H11A REST ZNF623 IPO8 DDX11-AS1 DDX11 SINHCAF FLJ13224 BICD1 CAPRIN2 RNU6-618P DENND5B-AS1 DENND5B
GH12H031618 0.9 ENCODE 29.4 -924.0 -923988 3 HDAC1 ATF1 RARA ZNF766 ELK1 CAVIN1 ZBTB11 USF2 REST HDAC8 IPO8 DDX11 DDX11-AS1 AK4P3 GC12P031641
GH12H030807 1 Ensembl ENCODE 24.2 -111.5 -111506 0 CTCF RB1 ZNF384 RAD21 CC2D1A GATA3 ZNF366 ZNF547 SCRT2 SMC3 IPO8 GC12P030799 CAPRIN2
GH12H031121 1 Ensembl ENCODE 23.8 -422.5 -422524 0 ZIC2 ZEB1 HIC1 ZFHX2 GLIS2 PATZ1 ZNF600 PRDM10 EZH2 EGR2 DDX11 SINHCAF IPO8 FLJ13224 DDX11-AS1 LOC101060058 PIR58939 GC12P031123
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IPO8 on UCSC Golden Path with GeneCards custom track

Promoters for IPO8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000050498 395 2001 HDGF FOXA2 ARNT SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for IPO8 Gene

Chromosome:
12
Start:
30,628,981 bp from pter
End:
30,695,995 bp from pter
Size:
67,015 bases
Orientation:
Minus strand

Genomic View for IPO8 Gene

Genes around IPO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO8 Gene

Proteins for IPO8 Gene

  • Protein details for IPO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15397-IPO8_HUMAN
    Recommended name:
    Importin-8
    Protein Accession:
    O15397
    Secondary Accessions:
    • B7Z7M3

    Protein attributes for IPO8 Gene

    Size:
    1037 amino acids
    Molecular mass:
    119938 Da
    Quaternary structure:
    • Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes.

    Alternative splice isoforms for IPO8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO8 Gene

Post-translational modifications for IPO8 Gene

  • Ubiquitination at posLast=510510
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPO8 Gene

Domains & Families for IPO8 Gene

Gene Families for IPO8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for IPO8 Gene

Suggested Antigen Peptide Sequences for IPO8 Gene

Graphical View of Domain Structure for InterPro Entry

O15397

UniProtKB/Swiss-Prot:

IPO8_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO8: view

Function for IPO8 Gene

Molecular function for IPO8 Gene

UniProtKB/Swiss-Prot Function:
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

Phenotypes From GWAS Catalog for IPO8 Gene

Gene Ontology (GO) - Molecular Function for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17932509
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with IPO8: view
genes like me logo Genes that share phenotypes with IPO8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IPO8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO8 Gene

Localization for IPO8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO8 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IPO8: view

Pathways & Interactions for IPO8 Gene

genes like me logo Genes that share pathways with IPO8: view

Pathways by source for IPO8 Gene

Gene Ontology (GO) - Biological Process for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 9214382
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with IPO8: view

No data available for SIGNOR curated interactions for IPO8 Gene

Drugs & Compounds for IPO8 Gene

(2) Drugs for IPO8 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO8: view

Transcripts for IPO8 Gene

Unigene Clusters for IPO8 Gene

Importin 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IPO8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IPO8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26a · 26b
SP1:
SP2:
SP3:

Relevant External Links for IPO8 Gene

GeneLoc Exon Structure for
IPO8
ECgene alternative splicing isoforms for
IPO8

Expression for IPO8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPO8 Gene

Protein differential expression in normal tissues from HIPED for IPO8 Gene

This gene is overexpressed in Bone (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPO8 Gene



Protein tissue co-expression partners for IPO8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPO8 Gene:

IPO8

SOURCE GeneReport for Unigene cluster for IPO8 Gene:

Hs.505136

Evidence on tissue expression from TISSUES for IPO8 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with IPO8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO8 Gene

Orthologs for IPO8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPO8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO8 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia IPO8 33 34
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia IPO8 33 34
  • 93.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IPO8 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo8 33 16 34
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO8 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686774 33
  • 82.29 (n)
chicken
(Gallus gallus)
Aves IPO8 33 34
  • 79.99 (n)
lizard
(Anolis carolinensis)
Reptilia IPO8 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo8 33
  • 70.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ipo8 33 34
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta msk 34
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD5 34
  • 21 (a)
ManyToMany
SXM1 34
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3218 34
  • 49 (a)
OneToMany
Species where no ortholog for IPO8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO8 Gene

ENSEMBL:
Gene Tree for IPO8 (if available)
TreeFam:
Gene Tree for IPO8 (if available)

Paralogs for IPO8 Gene

Paralogs for IPO8 Gene

(1) SIMAP similar genes for IPO8 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IPO8 Gene

genes like me logo Genes that share paralogs with IPO8: view

Variants for IPO8 Gene

Sequence variations from dbSNP and Humsavar for IPO8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000050354 -- 30,661,731(+) TAAGG(A/C)GAAAT intron-variant
rs1000110195 -- 30,696,364(+) TTTAG(A/G)TACCA upstream-variant-2KB
rs1000248678 -- 30,642,762(+) AGGAC(A/G)AGACA intron-variant
rs1000386443 -- 30,642,456(+) TCTGT(A/G)TACAT intron-variant
rs1000397962 -- 30,642,398(+) TATCC(A/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO8 Gene

Variant ID Type Subtype PubMed ID
nsv515645 CNV loss 19592680
nsv832361 CNV loss 17160897

Variation tolerance for IPO8 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO8 Gene

Disorders for IPO8 Gene

Relevant External Links for IPO8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO8

No disorders were found for IPO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO8 Gene

Publications for IPO8 Gene

  1. A novel class of RanGTP binding proteins. (PMID: 9214382) Görlich D … Izaurralde E (The Journal of cell biology 1997) 2 3 4 60
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L … Meister G (Cell 2009) 3 22 60
  3. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PMID: 19014639) Nguewa PA … Calvo A (BMC molecular biology 2008) 3 22 60
  4. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PMID: 11682607) Dean KA … Fried HM (Journal of cell science 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for IPO8 Gene

Sources for IPO8 Gene

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