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IPO8 Gene

protein-coding   GIFtS: 55
GCID: GC12M030682

Importin 8

(Previous name: RAN binding protein 8)
(Previous symbol: RANBP8)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Importin 81 2     imp82
RANBP81 2 3 5     importin-82
RAN Binding Protein 81 2     Imp83
Ran-Binding Protein 82 3     RanBP83

External Ids:    HGNC: 98531   Entrez Gene: 105262   Ensembl: ENSG000001337047   OMIM: 6056005   UniProtKB: O153973   

Export aliases for IPO8 gene to outside databases

Previous GC identifers: GC12M030805 GC12M030673 GC12M030675 GC12M030547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IPO8 Gene:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear
localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran
targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the
nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jul 2010)

GeneCards Summary for IPO8 Gene:
IPO8 (importin 8) is a protein-coding gene. Diseases associated with IPO8 include ataxia. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is IPO7.

UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
Function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor
or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is
thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import
substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the
nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is
re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear
import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between
the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IPO8 gene promoter:
         GR   GR-beta   GR-alpha   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO8 promoter sequence
   Search Chromatin IP Primers for IPO8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IPO8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

IPO8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M030682:  view genomic region     (about GC identifiers)

Start:
30,781,915 bp from pter      End:
30,848,929 bp from pter
Size:
67,015 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397 (See protein sequence)
Recommended Name: Importin-8  
Size: 1037 amino acids; 119938 Da
Subunit: Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes
Secondary accessions: B7Z7M3
Alternative splicing: 2 isoforms:  O15397-1   O15397-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IPO8: NX_O15397

Explore proteomics data for IPO8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys510
  • Modification sites at PhosphoSitePlus

  • See IPO8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177924.1  NP_006381.2  

    ENSEMBL proteins: 
     ENSP00000256079   ENSP00000444520   ENSP00000446232   ENSP00000439556   ENSP00000440979  
     ENSP00000443789   ENSP00000439413   ENSP00000444050   ENSP00000446254  

    IPO8 Human Recombinant Protein Products:

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    Novus Biologicals IPO8 Protein
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    Cloud-Clone Corp. Proteins for IPO8

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    IPO8 Assay Products:

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    Cloud-Clone Corp. CLIAs for IPO8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013713 Cse1
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O15397

    ProtoNet protein and cluster: O15397

    1 Blocks protein domain: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
    Similarity: Belongs to the importin beta family
    Similarity: Contains 1 importin N-terminal domain


    IPO8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO8_HUMAN, O15397
    Function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor
    or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is
    thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import
    substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the
    nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is
    re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear
    import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between
    the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17932509
    GO:0008536Ran GTPase binding IEA--
         
    IPO8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IPO8:
     G2 arrest  Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IPO8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPO8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IPO8

    miRNA
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    miRTarBase miRNAs that target IPO8:
    hsa-mir-1 (MIRT023609), hsa-mir-155-5p (MIRT020599), hsa-mir-193b-3p (MIRT041468), hsa-let-7b-5p (MIRT032284)

    Block miRNA regulation of human, mouse, rat IPO8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPO8 (see all 45):
    hsa-miR-4307 hsa-miR-429 hsa-miR-218 hsa-miR-759 hsa-miR-3916 hsa-miR-124 hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidIPO8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IPO8

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IPO8 (NM_006390)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPO8_HUMAN, O15397: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    IPO8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IPO8
    Interactions:

        Search GeneGlobe Interaction Network for IPO8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IPO8 (O153971, 2, 3 ENSP000002560794) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO2Q9UKV81, 2, 3, ENSP000002205924EBI-358808,EBI-528269 MINT-6489217 I2D: score=2 STRING: ENSP00000220592
    AGO3Q9H9G71, 2, 3, ENSP000003622874EBI-358808,EBI-2267883 MINT-6489217 I2D: score=2 STRING: ENSP00000362287
    AGO1Q9UL181, 3, ENSP000003623004EBI-358808,EBI-527363 I2D: score=2 STRING: ENSP00000362300
    TNFRSF1AP194382, 3MINT-49303 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49379 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction TAS9214382

    IPO8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IPO8

    1 HMDB Compound for IPO8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IPO8 gene (2 alternative transcripts): 
    NM_001190995.1  NM_006390.3  

    Unigene Cluster for IPO8:

    Importin 8
    Hs.505136  [show with all ESTs]
    Unigene Representative Sequence: NM_006390
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256079(uc010sjt.2 uc001rjd.3 uc001rje.1) ENST00000544829
    ENST00000535598 ENST00000542464 ENST00000535989 ENST00000540979 ENST00000543446
    ENST00000358724 ENST00000545077 ENST00000538338
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat IPO8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPO8 (see all 45):
    hsa-miR-4307 hsa-miR-429 hsa-miR-218 hsa-miR-759 hsa-miR-3916 hsa-miR-124 hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidIPO8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IPO8
    Clone
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    OriGene clones in human, mouse for IPO8 (see all 10)
    OriGene ORF clones in mouse, rat for IPO8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IPO8 (NM_006390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IPO8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IPO8
      QuantiTect SYBR Green Assays in human, mouse, rat IPO8
      QuantiFast Probe-based Assays in human, mouse, rat IPO8

    Additional mRNA sequence: 

    AK000201.1 AK130090.1 AK302260.1 U77494.1 

    9 DOTS entries:

    DT.100776146  DT.442549  DT.121120385  DT.91697936  DT.121120371  DT.121120375  DT.95371399  DT.97819589 
    DT.91912038 

    Selected AceView cDNA sequences (see all 148):

    Z43332 AA343858 AU125897 N40895 Z45833 AA047641 BX480054 BX953283 
    BQ773798 AI160299 F02755 N91588 CA432065 BG574795 BG035092 AW295358 
    BM751103 CA427400 Z43133 BU620791 AA236954 AA620453 AA866048 BG777887 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IPO8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26a · 26b
    SP1:                  
    SP2:                  
    SP3:                  


    ECgene alternative splicing isoforms for IPO8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IPO8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTTTTGA
    IPO8 Expression
    About this image

    IPO8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IPO8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505136
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IPO8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo81 , 5 importin 81, 5 86.12(n)1
    92.37(a)1
      6 (78.57 cM)5
    3207271  NM_001081113.11  NP_001074582.11 
     1487706835 
    chicken
    (Gallus gallus)
    Aves IPO81 importin 8 79.99(n)
    87(a)
      418142  XM_416373.4  XP_416373.4 
    lizard
    (Anolis carolinensis)
    Reptilia IPO86
    importin 8
    84(a)
    1 ↔ 1
    5(10868902-10917486)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX714249.12   -- 78.74(n)    BX714249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM083089.12   -- 71.89(n)    BM083089.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msk6
    moleskin
    48(a)
    1 → many
    3L(8109279-8114679)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SXM16
    NMD56
    Nuclear transport factor (karyopherin) involved in...
    Karyopherin, a carrier protein involved in nuclear...
    21(a)
    21(a)
    many ↔ many
    many ↔ many
    IV(1263324-1266158) YDR395W
    X(669522-672668) YJR132W


    ENSEMBL Gene Tree for IPO8 (if available)
    TreeFam Gene Tree for IPO8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IPO8 gene
    IPO72  
    1 SIMAP similar gene for IPO8 using alignment to 8 protein entries:     IPO8_HUMAN (see all proteins):
    IPO7

    IPO8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IPO8
    PGOHUM00000259510


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IPO8 (see all 1312)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73117111,2
    C,F--30781496(+) gtttgT/Cgtaag 2 -- ds50012Minor allele frequency- C:0.05WA NA 238
    rs1869698201,2
    C--30781528(+) AATAAC/TAAAAT 2 -- ds50010--------
    rs1922333171,2
    --30781776(+) CTGTTC/TCTGAT 2 -- ds50010--------
    rs23522101,2
    C,F,O,H--30781829(+) AGGTCC/ACCAGG 2 -- ds500128Minor allele frequency- A:0.39NS EA NA WA CSA 2492
    rs64879231,2
    C,F,A,H--30781912(+) CACAAG/AAGTTC 2 -- ds500134Minor allele frequency- A:0.44NA NS EA WA CSA 2921
    rs788514291,2
    C,F--30781939(+) GTCCGC/TATTTT 2 -- ut311Minor allele frequency- T:0.02WA 118
    rs1858177561,2
    --30782058(+) AGATAA/GGGTAA 2 -- ut310--------
    rs73271,2
    C,F,O,A,H--30782076(-) AAGAGG/ATATTA 2 -- ut31 trp334Minor allele frequency- A:0.43MN NA NS EA WA CSA 3292
    rs1140976771,2
    C,F--30782249(+) TCTTTC/TGCTTC 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs73261,2
    C,F,A,H--30782301(-) TCTGCC/TCCTCC 2 -- ut31 trp318Minor allele frequency- T:0.45MN NS EA NA WA CSA 1164

    HapMap Linkage Disequilibrium report for IPO8 (30781915 - 30848929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IPO8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832361CNV Loss17160897
    nsv515645CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605600    OMIM disorders: --

    1 disease for IPO8:    About MalaCards
    ataxia


    IPO8 for disorders           About GeneDecksing


    Export disorders for IPO8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IPO8 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with IPO8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of RanGTP binding proteins. (PubMed id 9214382)1, 2, 3 Goerlich D.... Izaurralde E. (J. Cell Biol. 1997)
    2. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PubMed id 11682607)1, 2 Dean K.A.... Fried H.M. (J. Cell Sci. 2001)
    3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 9 Weinmann L.... Meister G. (Cell 2009)
    4. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PubMed id 19014639)1, 9 Nguewa P.A....Calvo A. (BMC Mol. Biol. 2008)
    5. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10526 HGNC: 9853 AceView: IPO8 Ensembl:ENSG00000133704 euGenes: HUgn10526
    ECgene: IPO8 H-InvDB: IPO8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IPO8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IPO8 gene:
    Search GeneIP for patents involving IPO8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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