Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPO8 Gene

protein-coding   GIFtS: 52
GCID: GC12M030682

importin 8

(Previous name: RAN binding protein 8 )
(Previous symbol: RANBP8)
 Explore 4 diseases affiliated with
IPO8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IPO8    

Aliases
for IPO8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Importin 81 2     Imp83
RANBP81 2 3 5     Importin-81
RAN Binding Protein 81 2     Imp83
Ran-Binding Protein 82 3     RanBP83
IMP81     

External Ids:    HGNC: 98531   Entrez Gene: 105262   Ensembl: ENSG000001337047   OMIM: 6056005   UniProtKB: O153973   

Export aliases for IPO8 gene to outside databases

Previous GC identifers: GC12M030805 GC12M030673 GC12M030675 GC12M030547


Summaries
for IPO8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IPO8:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear
localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets
that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore
complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
Function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as
an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve
itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through
the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC,
Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an
asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates
the nuclear import of SRP19




Genomic Views
for IPO8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPO8 gene promoter:
         GR   GR-beta   GR-alpha   AP-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IPO8 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPO8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11.21

IPO8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M030682:  view genomic region     (about GC identifiers)

Start:
 30,781,915 bp from pter      End:
 30,848,929 bp from pter
Size:
 67,015 bases      Orientation:
 minus strand

Proteins
for IPO8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397 (See protein sequence)
Recommended Name: Importin-8  
Size: 1037 amino acids; 119938 Da
Subunit: Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: B7Z7M3
Alternative splicing: 2 isoforms:  O15397-1   O15397-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IPO8: NX_O15397

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15397

    • IPO8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177924.1  NP_006381.2  

    ENSEMBL proteins: 
     ENSP00000256079   ENSP00000444520   ENSP00000446232   ENSP00000439556   ENSP00000440979  
     ENSP00000443789   ENSP00000439413   ENSP00000444050   ENSP00000446254  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for IPO8 
    GenScript Custom Purified and Recombinant Proteins Services for IPO8
    Novus Biologicals IPO8 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IPO8

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005643nuclear pore IEA--
    GO:0005737cytoplasm IEA--


    IPO8 for ontologies           About GeneDecksing



    IPO8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IPO8 
    GenScript Custom Superior Antibodies Services for IPO8
    Novus Biologicals IPO8 Antibodies
    Search for Antibodies for IPO8 at Abcam  
    Uscn Antibodies for IPO8
    ThermoFisher Antibody for IPO8

    Assay Products for IPO8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IPO8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IPO8

    Protein Domains /
    Families
    for IPO8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IPO8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold
     IPR013713 Exportin/Importin_Cse1-like

    Graphical View of Domain Structure for InterPro Entry O15397

    ProtoNet protein and cluster: O15397

    1 Blocks protein family: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
    Similarity: Belongs to the importin beta family
    Similarity: Contains 1 importin N-terminal domain


    Function
    for IPO8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IPO8_HUMAN, O15397
    Function: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as
    an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve
    itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through
    the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC,
    Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an
    asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates
    the nuclear import of SRP19

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IPO8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPO8
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO8 (see all 45):
    hsa-miR-4307 hsa-miR-429 hsa-miR-218 hsa-miR-759 hsa-miR-3916 hsa-miR-124 hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IPO8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPO8 (see all 4)
    OriGene shRNA RFP: IPO8
    OriGene siRNA: IPO8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPO8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IPO8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPO8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPO8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): IPO8 (NM_006390)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IPO8
    Search LifeMap BioReagents cell lines for IPO8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO8

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19167051
    GO:0008536Ran GTPase binding TAS9214382
    GO:0008565protein transporter activity IEA--


    IPO8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IPO8:
     G2 arrest  Increased 8N DNA content 


    Pathways & Interactions
    for IPO8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IPO8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/83 Interacting proteins for IPO8 (O153971, 2, 3 ENSP000002560794) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO3Q9H9G71, 2, 3, ENSP000003622874EBI-358808,EBI-2267883 MINT-6489217 I2D: score=2 STRING: ENSP00000362287
    EIF2C2Q9UKV81, 2, 3EBI-358808,EBI-528269 MINT-6489217 I2D: score=2 
    EIF2C3Q9H9G71, 2, 3EBI-358808,EBI-2267883 MINT-6489217 I2D: score=2 
    ATXN1P542532, 3, ENSP000002447694MINT-2868490 MINT-2868471 I2D: score=3 STRING: ENSP00000244769
    AGO1Q9UL181, 3, ENSP000003623004EBI-358808,EBI-527363 I2D: score=2 STRING: ENSP00000362300
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction TAS9214382


    IPO8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IPO8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPO8

    1 HMDB Compound for IPO8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about IPO8 

    Transcripts
    for IPO8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IPO8 gene (2 alternative transcripts): 
    NM_001190995.1  NM_006390.3  

    Unigene Cluster for IPO8:

    Importin 8
    Hs.505136  [show with all ESTs]
    Unigene Representative Sequence: NM_006390
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256079(uc010sjt.2 uc001rjd.3 uc001rje.1) ENST00000544829
    ENST00000535598 ENST00000542464 ENST00000535989 ENST00000540979 ENST00000543446
    ENST00000358724 ENST00000545077 ENST00000538338

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IPO8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPO8
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO8 (see all 45):
    hsa-miR-4307 hsa-miR-429 hsa-miR-218 hsa-miR-759 hsa-miR-3916 hsa-miR-124 hsa-miR-298 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IPO8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPO8 (see all 4)
    OriGene shRNA RFP: IPO8
    OriGene siRNA: IPO8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPO8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPO8 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPO8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): IPO8 (NM_006390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPO8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPO8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPO8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO8

    Additional cDNA sequence: 

    AK000201.1 AK130090.1 AK302260.1 U77494.1 

    9 DOTS entries:

    DT.100776146  DT.442549  DT.121120385  DT.91697936  DT.121120371  DT.121120375  DT.95371399  DT.97819589 
    DT.91912038 

    24/148 AceView cDNA sequences (see all 148):

    AA620453 N91588 BU620791 AA866048 Z43133 BM751103 AA047641 CA432065 
    N40895 AW295358 BG035092 AA236954 F02755 AU125897 BX953283 BQ773798 
    Z45833 BX480054 AA343858 Z43332 AI160299 BG574795 CA427400 W42748 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IPO8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                    -                                                                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26a · 26b
    SP1:                  
    SP2:                  
    SP3:                  


    ECgene alternative splicing isoforms for IPO8

    Expression
    for IPO8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPO8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATTTTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IPO8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPO8

    SOURCE GeneReport for Unigene cluster: Hs.505136
        SABiosciences Custom PCR Arrays for IPO8
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPO8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPO8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPO8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO8

    Orthologs
    for IPO8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO8 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IPO81 importin 8 80.24(n)
    87.22(a)    		   418142  XM_416373.3  XP_416373.3 
    lizard
    (Anolis carolinensis)    		 Reptilia IPO86
    		 --
    		 84(a)
    		 1 ↔ 1
    		 5(10869437-10916710)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX714249.12   -- 78.74(n)    BX714249.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BM083089.12   -- 71.89(n)    BM083089.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta msk6
    		 moleskin
    		 47(a)
    		 1 → many
    		 3L(8109279-8114679)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SAD26
    AT3G590206
    		 Importin 7-like protein URM9
    armadillo/beta-catenin-like repeat-containing prot...
    		 28(a)
    27(a)
    		 many ↔ many
    many ↔ many
    		 2(13464298-13471821)
    3(21810260-21817555)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 importin-7, putative, expressed
    (see all 3)    		 29(a)
    27(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 4(15693255-15700987)
    2(16202461-16210607)


    ENSEMBL Gene Tree for IPO8 (if available)
    TreeFam Gene Tree for IPO8 (if available) 

    Paralogs
    for IPO8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPO8 gene
    IPO72  
    1 SIMAP similar gene for IPO8 using alignment to 8 protein entries:     IPO8_HUMAN (see all proteins):
    IPO7

    IPO8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IPO8
    PGOHUM00000259510


    Genomic Variants
    for IPO8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1093 NCBI SNPs in IPO8 are shown (see all 1093)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs73117111,2
    		C,F,--30781496(+) gtttgT/Cgtaag 2 -- ds50012Minor allele frequency- C:0.05WA NA 238
    rs1869698201,2
    		--30781528(+) AATAAC/TAAAAT 2 -- ds50010--------
    rs1922333171,2
    		--30781776(+) CTGTTC/TCTGAT 2 -- ds50010--------
    rs23522101,2
    		C,F,O,H,--30781829(+) AGGTCC/ACCAGG 2 -- ds500128Minor allele frequency- A:0.39NS EA NA WA CSA 2492
    rs64879231,2
    		C,F,A,H,--30781912(+) CACAAG/AAGTTC 2 -- ds500134Minor allele frequency- A:0.44NA NS EA WA CSA 2921
    rs788514291,2
    		C,F,--30781939(+) GTCCGC/TATTTT 2 -- ut311Minor allele frequency- T:0.02WA 118
    rs1858177561,2
    		--30782058(+) AGATAA/GGGTAA 2 -- ut310--------
    rs73271,2
    		C,F,O,A,H,--30782076(-) AAGAGG/ATATTA 2 -- ut31 trp334Minor allele frequency- A:0.43MN NA NS EA WA CSA 3292
    rs1140976771,2
    		C,F,--30782249(+) TCTTTC/TGCTTC 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs73261,2
    		C,F,A,H,--30782301(-) TCTGCC/TCCTCC 2 -- ut31 trp318Minor allele frequency- T:0.45MN NS EA NA WA CSA 1164

    HapMap Linkage Disequilibrium report for IPO8 (30781915 - 30848929 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IPO8
         1 CNV: 49044

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPO8
    DNA2.0 Custom Variant and Variant Library Synthesis for IPO8

    Disorders / Diseases
    for IPO8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IPO8 for disorders           About GeneDecksing

    OMIM gene information: 605600    OMIM disorders: --

    4 diseases for IPO8:    About MalaCards
    ataxia    immunodeficiency    malaria    alcoholism


    Export disorders for IPO8 gene to outside databases

    Publications
    for IPO8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPO8 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with IPO8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of RanGTP binding proteins. (PubMed id 9214382)1, 2, 3 Goerlich D.... Izaurralde E. (1997)
    2. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PubMed id 11682607)1, 2 Dean K.A.... Fried H.M. (2001)
    3. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 9 Weinmann L.... Meister G. (2009)
    4. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PubMed id 19014639)1, 9 Nguewa P.A....Calvo A. (2008)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)

    External Searches for IPO8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IPO8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10526 HGNC: 9853 AceView: IPO8 Ensembl:ENSG00000133704 euGenes: HUgn10526
    ECgene: IPO8 H-InvDB: IPO8

    Other Databases showing IPO8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IPO8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPO8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IPO8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IPO8 gene:
    Search GeneIP for patents involving IPO8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IPO8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for IPO8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPO8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPO8  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IPO8   OriGene 3'-UTR Clone for IPO8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPO8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPO8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IPO8   OriGene Custom Protein Services for IPO8  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IPO8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPO8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPO8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPO8
     GenScript Custom Purified and Recombinant Proteins Services for IPO8 GenScript cDNA clones with any tag delivered in your preferred vector for IPO8
     GenScript Custom Assay Services for IPO8 GenScript Custom Superior Antibodies Services for IPO8
     GenScript Custom overexpressing Cell Line Services for IPO8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IPO8 promoter
     Search Chromatin IP Primers for IPO8
     RT2 qPCR Primer Assay in human, mouse, rat IPO8
     Search GNC Networks for IPO8
     SABiosciences Custom PCR Arrays for IPO8
     Search Tocris compounds for IPO8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IPO8 antibodies
     IPO8 proteins
     Search for Antibodies for IPO8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for IPO8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     IPO8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IPO8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO8
     SwitchGear 3'UTR luciferase reporter plasmids for IPO8
     SwitchGear Promoter luciferase reporter plasmids for IPO8
     ThermoFisher Antibody for IPO8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO8
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IPO8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4