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Aliases for IPO8 Gene

Aliases for IPO8 Gene

  • Importin 8 2 3 5
  • RAN Binding Protein 8 2 3
  • Ran-Binding Protein 8 3 4
  • RANBP8 3 4
  • Imp8 3 4
  • Importin-8 3

External Ids for IPO8 Gene

Previous HGNC Symbols for IPO8 Gene

  • RANBP8

Previous GeneCards Identifiers for IPO8 Gene

  • GC12M030805
  • GC12M030682
  • GC12M030673
  • GC12M030675
  • GC12M030547

Summaries for IPO8 Gene

Entrez Gene Summary for IPO8 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for IPO8 Gene

IPO8 (Importin 8) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. GO annotations related to this gene include binding and Ran GTPase binding. An important paralog of this gene is IPO7.

UniProtKB/Swiss-Prot for IPO8 Gene

  • Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO8 Gene

Genomics for IPO8 Gene

Regulatory Elements for IPO8 Gene

Enhancers for IPO8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F030694 1 ENCODE 52.5 +0.5 482 2.4 HDGF CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 IPO8 LOC105369720
GH12F030807 0.7 Ensembl ENCODE 24.2 -111.5 -111522 0.6 CTCF ZNF384 RAD21 ZNF366 SCRT2 ZNF547 SMC3 SCRT1 ZNF362 ZNF680 IPO8 GC12P030799 CAPRIN2
GH12F031118 0.5 Ensembl ENCODE 23.8 -422.9 -422906 1.4 ELF3 ATF1 ZNF76 KLF17 RAD21 ZNF2 ZEB1 GLIS2 ZNF207 CREM FAM60A IPO8 FLJ13224 DDX11-AS1 DDX11 GC12P031123 LOC101060058 PIR58939
GH12F030725 0.7 Ensembl ENCODE 19 -30.0 -30010 1.0 SCRT1 JUN CEBPB ZBTB40 EP300 RAD21 JUND MAFF ATF3 ZNF366 IPO8 LOC645485
GH12F031072 0.2 ENCODE 14.5 -377.9 -377878 2.3 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF263 DDX11 IPO8 DDX11-AS1 ENSG00000212533 GC12M031076
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IPO8 on UCSC Golden Path with GeneCards custom track

Promoters for IPO8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243334 495 2201 HDGF CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF548

Genomic Location for IPO8 Gene

Chromosome:
12
Start:
30,628,981 bp from pter
End:
30,695,995 bp from pter
Size:
67,015 bases
Orientation:
Minus strand

Genomic View for IPO8 Gene

Genes around IPO8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO8 Gene

Proteins for IPO8 Gene

  • Protein details for IPO8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15397-IPO8_HUMAN
    Recommended name:
    Importin-8
    Protein Accession:
    O15397
    Secondary Accessions:
    • B7Z7M3

    Protein attributes for IPO8 Gene

    Size:
    1037 amino acids
    Molecular mass:
    119938 Da
    Quaternary structure:
    • Forms a heterodimer with KPNB1. Interacts with SRP19. Binds directly to nuclear pore complexes.

    Alternative splice isoforms for IPO8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO8 Gene

Post-translational modifications for IPO8 Gene

  • Ubiquitination at Lys 510
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPO8 Gene

Domains & Families for IPO8 Gene

Gene Families for IPO8 Gene

Protein Domains for IPO8 Gene

Suggested Antigen Peptide Sequences for IPO8 Gene

Graphical View of Domain Structure for InterPro Entry

O15397

UniProtKB/Swiss-Prot:

IPO8_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO8: view

Function for IPO8 Gene

Molecular function for IPO8 Gene

UniProtKB/Swiss-Prot Function:
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

Gene Ontology (GO) - Molecular Function for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17932509
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with IPO8: view
genes like me logo Genes that share phenotypes with IPO8: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO8 Gene

Localization for IPO8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO8 Gene COMPARTMENTS Subcellular localization image for IPO8 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,TAS --
genes like me logo Genes that share ontologies with IPO8: view

Pathways & Interactions for IPO8 Gene

genes like me logo Genes that share pathways with IPO8: view

Pathways by source for IPO8 Gene

Gene Ontology (GO) - Biological Process for IPO8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction TAS 9214382
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with IPO8: view

No data available for SIGNOR curated interactions for IPO8 Gene

Drugs & Compounds for IPO8 Gene

(2) Drugs for IPO8 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO8: view

Transcripts for IPO8 Gene

Unigene Clusters for IPO8 Gene

Importin 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26a · 26b
SP1:
SP2:
SP3:

Relevant External Links for IPO8 Gene

GeneLoc Exon Structure for
IPO8
ECgene alternative splicing isoforms for
IPO8

Expression for IPO8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPO8 Gene

Protein differential expression in normal tissues from HIPED for IPO8 Gene

This gene is overexpressed in Bone (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPO8 Gene



Protein tissue co-expression partners for IPO8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPO8 Gene:

IPO8

SOURCE GeneReport for Unigene cluster for IPO8 Gene:

Hs.505136
genes like me logo Genes that share expression patterns with IPO8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPO8 Gene

Orthologs for IPO8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPO8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO8 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia IPO8 34 35
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia IPO8 34 35
  • 93.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IPO8 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo8 34 16 35
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO8 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686774 34
  • 82.29 (n)
chicken
(Gallus gallus)
Aves IPO8 34 35
  • 79.99 (n)
lizard
(Anolis carolinensis)
Reptilia IPO8 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo8 34
  • 70.29 (n)
zebrafish
(Danio rerio)
Actinopterygii ipo8 34 35
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta msk 35
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD5 35
  • 21 (a)
ManyToMany
SXM1 35
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3218 35
  • 49 (a)
OneToMany
Species where no ortholog for IPO8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO8 Gene

ENSEMBL:
Gene Tree for IPO8 (if available)
TreeFam:
Gene Tree for IPO8 (if available)

Paralogs for IPO8 Gene

Paralogs for IPO8 Gene

(1) SIMAP similar genes for IPO8 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for IPO8 Gene

genes like me logo Genes that share paralogs with IPO8: view

Variants for IPO8 Gene

Sequence variations from dbSNP and Humsavar for IPO8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10219608 -- 30,681,103(+) TAAAA(C/T)ATGTT intron-variant
rs10219701 -- 30,660,579(+) GATCA(C/T)ATCAG intron-variant
rs10444423 -- 30,679,845(+) ATTAT(G/T)CTTCC intron-variant
rs10506069 -- 30,673,690(+) GAATT(A/G)ATAGA intron-variant
rs10506070 -- 30,676,740(+) CAGAT(G/T)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO8 Gene

Variant ID Type Subtype PubMed ID
nsv515645 CNV loss 19592680
nsv832361 CNV loss 17160897

Variation tolerance for IPO8 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO8 Gene

Disorders for IPO8 Gene

Relevant External Links for IPO8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO8

No disorders were found for IPO8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO8 Gene

Publications for IPO8 Gene

  1. A novel class of RanGTP binding proteins. (PMID: 9214382) Goerlich D. … Izaurralde E. (J. Cell Biol. 1997) 2 3 4 64
  2. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PMID: 19167051) Weinmann L. … Meister G. (Cell 2009) 3 22 64
  3. Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens. (PMID: 19014639) Nguewa P.A. … Calvo A. (BMC Mol. Biol. 2008) 3 22 64
  4. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. (PMID: 11682607) Dean K.A. … Fried H.M. (J. Cell Sci. 2001) 3 4 64
  5. Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. (PMID: 27114554) Volpon L. … Borden K.L. (Proc. Natl. Acad. Sci. U.S.A. 2016) 3 64

Products for IPO8 Gene

Sources for IPO8 Gene

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