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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPO7 Gene

protein-coding   GIFtS: 59
GCID: GC11P009362

Importin 7

(Previous name: RAN binding protein 7)
(Previous symbol: RANBP7)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Importin 71 2     RAN Binding Protein 71
RANBP71 2 3 5     importin-72
Ran-Binding Protein 72 3     RanBP73
Imp72 3     

External Ids:    HGNC: 98521   Entrez Gene: 105272   Ensembl: ENSG000002053397   OMIM: 6055865   UniProtKB: O953733   

Export aliases for IPO7 gene to outside databases

Previous GC identifers: GC11P009976 GC11P009445 GC11P009370 GC11P009077


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IPO7 Gene:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear
localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran
targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta,
this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and
also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and
transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and
in both directions. At least four importin beta-like transport receptors, namely importin beta itself,
transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for IPO7 Gene: 
IPO7 (importin 7) is a protein-coding gene. Diseases associated with IPO7 include triple-a syndrome, and acute myeloid leukemia. GO annotations related to this gene include histone binding and transporter activity. An important paralog of this gene is IPO8.

UniProtKB/Swiss-Prot: IPO7_HUMAN, O95373
Function: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an
adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to
serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates
through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side
of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from
the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought
to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and
nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a
beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import
of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in
importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In
vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1
infection, binds and mediates the nuclear import of HIV-1 Rev

Gene Wiki entry for IPO7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPO7 gene promoter:
         GR   NF-1   NF-1/L   USF1   HNF-4alpha2   c-Ets-1   HNF-4alpha1   YY1   USF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPO7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

IPO7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009362:  view genomic region     (about GC identifiers)

Start:
9,406,169 bp from pter      End:
9,469,674 bp from pter
Size:
63,506 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IPO7_HUMAN, O95373 (See protein sequence)
Recommended Name: Importin-7  
Size: 1038 amino acids; 119517 Da
Subunit: Interacts with H2A, H2B, H3 and H4 histones (By similarity). Forms a heterodimer with KPNB1. Interacts
with KPNB1, SNUPN, XPO1, RPL23A, RPS7, RPL5 and HIV-1 reverse transcription complex integrase. Binds directly to
nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A6NNM5 B2R786 Q1RMF7 Q9H177 Q9NTE3

Explore the universe of human proteins at neXtProt for IPO7: NX_O95373

Explore proteomics data for IPO7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95373

  • IPO7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IPO7 Protein Expression
    REFSEQ proteins: NP_006382.1  
    ENSEMBL proteins: 
     ENSP00000369042   ENSP00000433313   ENSP00000435235  

    Human Recombinant Protein Products for IPO7: 
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    Novus Biologicals IPO7 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IPO7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643nuclear pore TAS9214382
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    IPO7 for ontologies           About GeneDecksing



    IPO7 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for IPO7 
    Cloud-Clone Corp. CLIAs for IPO7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013713 Exportin/Importin_Cse1-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O95373

    ProtoNet protein and cluster: O95373

    1 Blocks protein domain: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: IPO7_HUMAN, O95373
    Similarity: Belongs to the importin beta family
    Similarity: Contains 1 importin N-terminal domain


    IPO7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO7_HUMAN, O95373
    Function: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an
    adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to
    serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates
    through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side
    of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from
    the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought
    to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and
    nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a
    beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import
    of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in
    importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In
    vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1
    infection, binds and mediates the nuclear import of HIV-1 Rev

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity TAS9214382
    GO:0005215transporter activity TAS9214382
    GO:0005488binding ----
    GO:0005515protein binding IPI15282309
    GO:0008536Ran GTPase binding IEA--
         
    IPO7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IPO7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IPO7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPO7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IPO7 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IPO7:
    ebv-mir-bart3 (MIRT005471)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPO7
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO7 (see all 120):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-300 hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidIPO7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IPO7
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    GenScript: all cDNA clones in your preferred vector: IPO7 (NM_006391)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO7
    Sirion Biotech Customized lentivirus for stable overexpression of IPO7 
                         Customized lentivirus expression plasmids for stable overexpression of IPO7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IPO7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/676 Interacting proteins for IPO7 (O953732, 3 ENSP000003690424) via UniProtKB, MINT, STRING, and/or I2D (see all 676)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IEA--
    GO:0006886intracellular protein transport ----
    GO:0007165signal transduction TAS9214382
    GO:0019048modulation by virus of host morphology or physiology IEA--

    IPO7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPO7

    1 HMDB Compound for IPO7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about IPO7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IPO7 gene: 
    NM_006391.2  

    Unigene Cluster for IPO7:

    Importin 7
    Hs.744911  [show with all ESTs]
    Unigene Representative Sequence: NM_006391
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379719(uc001mho.3) ENST00000533233 ENST00000527431 ENST00000533680
    ENST00000528833 ENST00000531235 ENST00000530037
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPO7
    8/120 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO7 (see all 120):
    hsa-miR-140-5p hsa-miR-576-3p hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-3607-3p hsa-miR-300 hsa-miR-15a
    SwitchGear 3'UTR luciferase reporter plasmidIPO7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IPO7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPO7
    Clone
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    OriGene clones in human, mouse for IPO7 (see all 7)
    OriGene ORF clones in mouse, rat for IPO7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IPO7 (NM_006391)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO7
    Sirion Biotech Customized lentivirus for stable overexpression of IPO7 
                         Customized lentivirus expression plasmids for stable overexpression of IPO7 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IPO7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPO7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPO7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO7

    Additional mRNA sequence: 

    AF098799.1 AK027487.1 AK027892.1 AK074908.1 AK312885.1 AL117596.1 AL137335.1 BC044914.2 
    BC114929.1 

    22 DOTS entries:

    DT.91958354  DT.319216  DT.95119773  DT.100744720  DT.95134538  DT.95196156  DT.95134595  DT.120734684 
    DT.100796274  DT.91795574  DT.95134596  DT.95134606  DT.100744721  DT.120734661  DT.92454394  DT.95134530 
    DT.95134607  DT.100796278  DT.101979888  DT.87005845  DT.92443762  DT.99934995 

    24/512 AceView cDNA sequences (see all 512):

    BP340851 T35658 AF098799 AA782674 CB177839 AA361547 BF000473 AU133218 
    AI631954 BM980653 BM725547 AA279417 BU689852 AA035371 BG286734 BM055322 
    BM055043 AI014837 AA126752 BM678167 CB177463 AA361541 N41641 N27273 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPO7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTGGCAA
    IPO7 Expression
    About this image


    See IPO7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPO7

    SOURCE GeneReport for Unigene cluster: Hs.744911
        SABiosciences Custom PCR Arrays for IPO7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO7 gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo71 , 5 importin 71, 5 92.58(n)1
    99.42(a)1
      7 (57.70 cM)5
    2337261  NM_181517.31  NP_852658.21 
     1100184255 
    chicken
    (Gallus gallus)
    Aves IPO71 importin 7 85.07(n)
    97.5(a)
      423046  XM_003641394.1  XP_003641442.1 
    lizard
    (Anolis carolinensis)
    Reptilia IPO76
    Uncharacterized protein
    97(a)
    1 ↔ 1
    1(64204351-64248879)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC525562 similar to RAN binding protein 7 80.3(n)    U71082.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc664252 hypothetical protein MGC66425 77.77(n)   393879  BC064673.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta msk1 moleskin 56.62(n)
    55.48(a)
      44747  NM_080041.2  NP_524780.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NMD5(YJR132W)4
    NMD51
    Karyopherin, a carrier protein involved in nuclear more4
    Nmd5p1
    44.62(n)1
    29.36(a)1
      10(669522-672668)4
    8535961, 4  NP_012666.21  NP_012666.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G590201 armadillo/beta-catenin-like repeat-containing protein 44.74(n)
    31.47(a)
      825071  NM_001035811.1  NP_001030888.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g04747001 hypothetical protein 47.5(n)
    32.03(a)
      4329353  NM_001053375.1  NP_001046840.1 


    ENSEMBL Gene Tree for IPO7 (if available)
    TreeFam Gene Tree for IPO7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPO7 gene
    IPO82  
    18/31 SIMAP similar genes for IPO7 using alignment to 4 protein entries:     IPO7_HUMAN (see all proteins) (see all similar genes):
    COX7A2    MTA3    ANAPC11    IFT122    CES4A    SPSB4
    ZNF83    LRRC36    NDUFS7    THADA    ZNF23    NSRP1
    UTY    ZNF415    MYO15B    C19orf47    NSD1    TMEM67

    IPO7 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for IPO7
    PGOHUM00000248332 PGOHUM00000259511 PGOHUM00000241299


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1291 SNPs in IPO7 are shown (see all 1291)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911202011,2
    --9404179(+) TGTGAA/GCCACC 1 -- us2k10--------
    rs1823952891,2
    --9404235(+) TCCAGA/GCACAG 1 -- us2k10--------
    rs1117829121,2
    F--9404297(+) AGGCTG/TTCGTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs775469191,2
    C--9404316(+) TTTTT-/TGTAAA 1 -- us2k10--------
    rs1856364801,2
    --9404356(+) TTAACA/GCATTG 1 -- us2k10--------
    rs1143070791,2
    C,F--9404357(+) TAACAC/TATTGT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1904045441,2
    --9404593(+) TACTGG/TATTCT 1 -- us2k10--------
    rs1830283571,2
    --9404600(+) TTCTTA/GCTATT 1 -- us2k10--------
    rs1437737861,2
    C--9404614(+) TTAACC/TAGTCC 1 -- us2k10--------
    rs752961761,2
    C,F--9404789(+) AAAGAG/TGACTT 1 -- us2k13Minor allele frequency- T:0.12WA CSA 122

    HapMap Linkage Disequilibrium report for IPO7 (9406169 - 9469674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IPO7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672268CNV Deletion23128226
    esv2441718CNV Deletion19546169
    esv2668301CNV Deletion23128226
    nsv508617CNV Loss20534489
    nsv442218CNV CNV18776908
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605586    OMIM disorders: --

    8 diseases for IPO7:    About MalaCards
    triple-a syndrome    acute myeloid leukemia    myeloid leukemia    hypertension
    hypoxia    leukemia    breast cancer    neuronitis


    IPO7 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IPO7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 20.2 3 16103209 (2)
    virus infection 0 1 16103209 (1)

    Genetic Association Database (GAD): IPO7
    Human Genome Epidemiology (HuGE) Navigator: IPO7 (1 document)

    Export disorders for IPO7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPO7 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with IPO7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of RanGTP binding proteins. (PubMed id 9214382)1, 2, 3 Goerlich D.... Izaurralde E. (1997)
    2. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. (PubMed id 10228156)1, 2, 9 Jaekel S.... Goerlich D. (1999)
    3. Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7. (PubMed id 12853482)1, 2, 9 Fassati A.... Mingot J.-M. (2003)
    4. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2, 9 Jaekel S. and Goerlich D. (1998)
    5. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2, 9 Arnold M.... Kehlenbach R.H. (2006)
    6. A genome-wide association study of hypertension and b lood pressure in African Americans. (PubMed id 19609347)1, 4 Adeyemo A....Rotimi C. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. CRM1-mediated recycling of snurportin 1 to the cytoplasm. (PubMed id 10209022)1, 2 Paraskeva E.... Goerlich D. (1999)
    10. Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication. (PubMed id 17360709)1, 9 Ao Z....Yao X. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10527 HGNC: 9852 AceView: IPO7 Ensembl:ENSG00000205339 euGenes: HUgn10527
    ECgene: IPO7 H-InvDB: IPO7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPO7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IPO7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IPO7 gene:
    Search GeneIP for patents involving IPO7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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