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Aliases for IPO7 Gene

Aliases for IPO7 Gene

  • Importin 7 2 3 5
  • RANBP7 3 4
  • Imp7 3 4
  • RAN Binding Protein 7 2
  • RAN-Binding Protein 7 3
  • Ran-Binding Protein 7 4

External Ids for IPO7 Gene

Previous HGNC Symbols for IPO7 Gene

  • RANBP7

Previous GeneCards Identifiers for IPO7 Gene

  • GC11P009976
  • GC11P009445
  • GC11P009370
  • GC11P009077

Summaries for IPO7 Gene

Entrez Gene Summary for IPO7 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPO7 Gene

IPO7 (Importin 7) is a Protein Coding gene. Diseases associated with IPO7 include hiv-1. GO annotations related to this gene include binding and histone binding. An important paralog of this gene is IPO8.

UniProtKB/Swiss-Prot for IPO7 Gene

  • Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Wiki entry for IPO7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO7 Gene

Genomics for IPO7 Gene

Regulatory Elements for IPO7 Gene

Promoters for IPO7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IPO7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IPO7 Gene

Chromosome:
11
Start:
9,384,622 bp from pter
End:
9,448,127 bp from pter
Size:
63,506 bases
Orientation:
Plus strand

Genomic View for IPO7 Gene

Genes around IPO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO7 Gene

Proteins for IPO7 Gene

  • Protein details for IPO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95373-IPO7_HUMAN
    Recommended name:
    Importin-7
    Protein Accession:
    O95373
    Secondary Accessions:
    • A6NNM5
    • B2R786
    • Q1RMF7
    • Q9H177
    • Q9NTE3

    Protein attributes for IPO7 Gene

    Size:
    1038 amino acids
    Molecular mass:
    119517 Da
    Quaternary structure:
    • Interacts with H2A, H2B, H3 and H4 histones (By similarity). Forms a heterodimer with KPNB1. Interacts with KPNB1, SNUPN, XPO1, RPL23A, RPS7, RPL5 and HIV-1 reverse transcription complex integrase. Binds directly to nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev.

neXtProt entry for IPO7 Gene

Proteomics data for IPO7 Gene at MOPED

Post-translational modifications for IPO7 Gene

  • Ubiquitination at Lys 990 and Lys 1018
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO7 Gene

No data available for DME Specific Peptides for IPO7 Gene

Domains & Families for IPO7 Gene

Gene Families for IPO7 Gene

Protein Domains for IPO7 Gene

Suggested Antigen Peptide Sequences for IPO7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95373

UniProtKB/Swiss-Prot:

IPO7_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO7: view

Function for IPO7 Gene

Molecular function for IPO7 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Ontology (GO) - Molecular Function for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with IPO7: view
genes like me logo Genes that share phenotypes with IPO7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO7 Gene

Localization for IPO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO7 Gene COMPARTMENTS Subcellular localization image for IPO7 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with IPO7: view

Pathways & Interactions for IPO7 Gene

SuperPathways for IPO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with IPO7: view

No data available for Pathways by source and SIGNOR curated interactions for IPO7 Gene

Drugs & Compounds for IPO7 Gene

(2) Drugs for IPO7 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO7: view

Transcripts for IPO7 Gene

Unigene Clusters for IPO7 Gene

Importin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO7 Gene

No ASD Table

Relevant External Links for IPO7 Gene

GeneLoc Exon Structure for
IPO7
ECgene alternative splicing isoforms for
IPO7

Expression for IPO7 Gene

mRNA expression in normal human tissues for IPO7 Gene

mRNA differential expression in normal tissues according to GTEx for IPO7 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for IPO7 Gene

This gene is overexpressed in Bone (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO7 Gene



SOURCE GeneReport for Unigene cluster for IPO7 Gene Hs.744911

genes like me logo Genes that share expression patterns with IPO7: view

Protein tissue co-expression partners for IPO7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IPO7 Gene

Orthologs for IPO7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO7 36
  • 100 (a)
OneToOne
IPO7 35
  • 99.78 (n)
  • 99.9 (a)
cow
(Bos Taurus)
Mammalia IPO7 36
  • 100 (a)
OneToOne
IPO7 35
  • 94.77 (n)
  • 99.9 (a)
dog
(Canis familiaris)
Mammalia IPO7 35
  • 94.77 (n)
  • 100 (a)
IPO7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo7 16
Ipo7 36
  • 99 (a)
OneToOne
Ipo7 35
  • 92.58 (n)
  • 99.42 (a)
oppossum
(Monodelphis domestica)
Mammalia IPO7 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ipo7 35
  • 91.94 (n)
  • 99.61 (a)
chicken
(Gallus gallus)
Aves IPO7 35
  • 85.07 (n)
  • 97.5 (a)
IPO7 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO7 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52556 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo7 35
  • 78.72 (n)
  • 92.48 (a)
Str.1398 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9019 35
zebrafish
(Danio rerio)
Actinopterygii ipo7 36
  • 85 (a)
OneToOne
ipo7 35
  • 73.64 (n)
  • 85.07 (a)
zgc66425 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007299 35
  • 54.94 (n)
  • 52.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta msk 35
  • 56.35 (n)
  • 54.79 (a)
msk 36
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL068C 35
  • 43 (n)
  • 27.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD5 35
  • 44.04 (n)
  • 28.72 (a)
NMD5 36
  • 22 (a)
ManyToMany
SXM1 36
  • 22 (a)
ManyToMany
NMD5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04202g 35
  • 43.36 (n)
  • 27.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59020 35
  • 45.05 (n)
  • 31.15 (a)
rice
(Oryza sativa)
Liliopsida Os02g0474700 35
  • 47.04 (n)
  • 30.84 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01939 35
  • 43.37 (n)
  • 30.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC550.11 35
  • 45.52 (n)
  • 31.78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2845 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3218 36
  • 52 (a)
OneToMany
Species with no ortholog for IPO7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO7 Gene

ENSEMBL:
Gene Tree for IPO7 (if available)
TreeFam:
Gene Tree for IPO7 (if available)

Paralogs for IPO7 Gene

Paralogs for IPO7 Gene

Pseudogenes.org Pseudogenes for IPO7 Gene

genes like me logo Genes that share paralogs with IPO7: view

Variants for IPO7 Gene

Sequence variations from dbSNP and Humsavar for IPO7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11042340 - 9,409,939(+) GCTTA(A/C)TACAT reference, missense
rs1015627 -- 9,448,318(-) AGAGA(A/T)GCCAG downstream-variant-500B
rs1020622 -- 9,448,245(-) CTATT(C/G)CAAGA downstream-variant-500B
rs1020623 -- 9,448,189(-) ATAAA(C/T)GGTCA downstream-variant-500B
rs2305501 -- 9,430,871(+) TGAAT(A/C/T)TAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO7 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv508617 CNV Loss 20534489
esv2441718 CNV Deletion 19546169
esv2672268 CNV Deletion 23128226
nsv442218 CNV CNV 18776908
esv2668301 CNV Deletion 23128226

Variation tolerance for IPO7 Gene

Residual Variation Intolerance Score: 4.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO7 Gene

HapMap Linkage Disequilibrium report
IPO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO7 Gene

Disorders for IPO7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IPO7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search IPO7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IPO7

Genetic Association Database (GAD)
IPO7
Human Genome Epidemiology (HuGE) Navigator
IPO7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO7
genes like me logo Genes that share disorders with IPO7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IPO7 Gene

Publications for IPO7 Gene

  1. A novel class of RanGTP binding proteins. (PMID: 9214382) Goerlich D. … Izaurralde E. (J. Cell Biol. 1997) 2 3 4 67
  2. ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins. (PMID: 19435463) Huang S. … Yu Y. (Biosci. Rep. 2010) 3 23
  3. Preferential utilization of Imp7/8 in nuclear import of Smads. (PMID: 18519565) Yao X. … Xu L. (J. Biol. Chem. 2008) 3 23
  4. Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication. (PMID: 17360709) Ao Z. … Yao X. (J. Biol. Chem. 2007) 3 23
  5. Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. (PMID: 17848547) Saijou E. … Miyajima A. (J. Biol. Chem. 2007) 3 23

Products for IPO7 Gene

Sources for IPO7 Gene

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