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Aliases for IPO7 Gene

Aliases for IPO7 Gene

  • Importin 7 2 3
  • RANBP7 3 4 6
  • Imp7 3 4
  • RAN Binding Protein 7 2
  • RAN-Binding Protein 7 3
  • Ran-Binding Protein 7 4
  • Importin-7 3

External Ids for IPO7 Gene

Previous Symbols for IPO7 Gene

  • RANBP7

Summaries for IPO7 Gene

Entrez Gene Summary for IPO7 Gene

  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPO7 Gene

IPO7 (Importin 7) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is IPO8.

UniProtKB/Swiss-Prot for IPO7 Gene

  • Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Wiki entry for IPO7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO7 Gene

Genomics for IPO7 Gene

Genomic Location for IPO7 Gene

Start:
9,384,622 bp from pter
End:
9,448,127 bp from pter
Size:
63,506 bases
Orientation:
Plus strand

Genomic View for IPO7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IPO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO7 Gene

Regulatory Elements for IPO7 Gene

Proteins for IPO7 Gene

  • Protein details for IPO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95373-IPO7_HUMAN
    Recommended name:
    Importin-7
    Protein Accession:
    O95373
    Secondary Accessions:
    • A6NNM5
    • B2R786
    • Q1RMF7
    • Q9H177
    • Q9NTE3

    Protein attributes for IPO7 Gene

    Size:
    1038 amino acids
    Molecular mass:
    119517 Da
    Quaternary structure:
    • Interacts with H2A, H2B, H3 and H4 histones (By similarity). Forms a heterodimer with KPNB1. Interacts with KPNB1, SNUPN, XPO1, RPL23A, RPS7, RPL5 and HIV-1 reverse transcription complex integrase. Binds directly to nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Binds to HIV-1 Rev.

neXtProt entry for IPO7 Gene

Proteomics data for IPO7 Gene at MOPED

Post-translational modifications for IPO7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys990 and Lys1018

Other Protein References for IPO7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPO7 Gene

Domains for IPO7 Gene

Gene Families for IPO7 Gene

HGNC:
  • IPO :Importins

Protein Domains for IPO7 Gene

UniProtKB/Swiss-Prot:

IPO7_HUMAN
Domain:
  • Contains 1 importin N-terminal domain.:
    • O95373
Family:
  • Belongs to the importin beta family.:
    • O95373
genes like me logo Genes that share domains with IPO7: view

Function for IPO7 Gene

Molecular function for IPO7 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Ontology (GO) - Molecular Function for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9214382
GO:0005488 binding --
GO:0005515 protein binding IPI 15282309
GO:0008536 Ran GTPase binding IEA --
GO:0030695 GTPase regulator activity TAS 9214382
genes like me logo Genes that share ontologies with IPO7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IPO7 Gene

Localization for IPO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO7 Gene COMPARTMENTS Subcellular localization image for IPO7 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore TAS 9214382
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IPO7: view

Pathways for IPO7 Gene

SuperPathways for IPO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006886 intracellular protein transport --
GO:0007165 signal transduction TAS 9214382
GO:0016032 viral process IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with IPO7: view

No data available for Pathways by source for IPO7 Gene

Compounds for IPO7 Gene

(1) HMDB Compounds for IPO7 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with IPO7: view

Transcripts for IPO7 Gene

Unigene Clusters for IPO7 Gene

Importin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO7 Gene

No ASD Table

Relevant External Links for IPO7 Gene

GeneLoc Exon Structure for
IPO7
ECgene alternative splicing isoforms for
IPO7

Expression for IPO7 Gene

mRNA expression in normal human tissues for IPO7 Gene

mRNA differential expression in normal tissues according to GTEx for IPO7 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO7 Gene

SOURCE GeneReport for Unigene cluster for IPO7 Gene Hs.744911

genes like me logo Genes that share expressions with IPO7: view

Orthologs for IPO7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO7 36
  • 99.78 (n)
  • 99.9 (a)
IPO7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IPO7 36
  • 94.77 (n)
  • 99.9 (a)
IPO7 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO7 36
  • 94.77 (n)
  • 100 (a)
IPO7 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo7 36
  • 92.58 (n)
  • 99.42 (a)
Ipo7 16
Ipo7 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IPO7 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ipo7 36
  • 91.94 (n)
  • 99.61 (a)
chicken
(Gallus gallus)
Aves IPO7 36
  • 85.07 (n)
  • 97.5 (a)
IPO7 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO7 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52556 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo7 36
  • 78.72 (n)
  • 92.48 (a)
Str.1398 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9019 36
zebrafish
(Danio rerio)
Actinopterygii ipo7 36
  • 73.64 (n)
  • 85.07 (a)
ipo7 37
  • 85 (a)
OneToOne
zgc66425 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007299 36
  • 54.94 (n)
  • 52.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta msk 36
  • 56.35 (n)
  • 54.79 (a)
msk 37
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL068C 36
  • 43 (n)
  • 27.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMD5 36
  • 44.04 (n)
  • 28.72 (a)
NMD5 37
  • 22 (a)
ManyToMany
NMD5 39
SXM1 37
  • 22 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04202g 36
  • 43.36 (n)
  • 27.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59020 36
  • 45.05 (n)
  • 31.15 (a)
rice
(Oryza sativa)
Liliopsida Os02g0474700 36
  • 47.04 (n)
  • 30.84 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01939 36
  • 43.37 (n)
  • 30.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC550.11 36
  • 45.52 (n)
  • 31.78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2845 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3218 37
  • 52 (a)
OneToMany
Species with no ortholog for IPO7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO7 Gene

ENSEMBL:
Gene Tree for IPO7 (if available)
TreeFam:
Gene Tree for IPO7 (if available)

Paralogs for IPO7 Gene

Paralogs for IPO7 Gene

Pseudogenes.org Pseudogenes for IPO7 Gene

genes like me logo Genes that share paralogs with IPO7: view

Variants for IPO7 Gene

Sequence variations from dbSNP and Humsavar for IPO7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4810 -- 9,446,820(-) TAAAA(C/T)AGAAA utr-variant-3-prime
rs8785 -- 9,446,907(+) CTAAC(A/G)TGTGT utr-variant-3-prime
rs14432 -- 9,446,771(-) TACAA(A/G)AAAAA utr-variant-3-prime
rs14433 -- 9,446,774(-) GTATA(A/C)AAGAA utr-variant-3-prime
rs1015627 -- 9,448,318(-) AGAGA(A/T)GCCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IPO7 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv508617 CNV Loss 20534489
esv2441718 CNV Deletion 19546169
esv2672268 CNV Deletion 23128226
nsv442218 CNV CNV 18776908
esv2668301 CNV Deletion 23128226

Relevant External Links for IPO7 Gene

HapMap Linkage Disequilibrium report
IPO7

Disorders for IPO7 Gene

(2) Novoseek inferred disease relationships for IPO7 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 20.2 2
virus infection 0 1

Relevant External Links for IPO7

Genetic Association Database (GAD)
IPO7
Human Genome Epidemiology (HuGE) Navigator
IPO7
genes like me logo Genes that share disorders with IPO7: view

No data available for UniProtKB/Swiss-Prot for IPO7 Gene

Publications for IPO7 Gene

  1. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jaekel S. … Goerlich D. (EMBO J. 1998) 3 4 23
  2. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. (PMID: 10228156) Jaekel S. … Goerlich D. (EMBO J. 1999) 3 4 23
  3. Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7. (PMID: 12853482) Fassati A. … Mingot J.-M. (EMBO J. 2003) 3 4 23
  4. A novel class of RanGTP binding proteins. (PMID: 9214382) Goerlich D. … Izaurralde E. (J. Cell Biol. 1997) 2 3 4
  5. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PMID: 16704975) Arnold M. … Kehlenbach R.H. (J. Biol. Chem. 2006) 3 4 23

Products for IPO7 Gene

Sources for IPO7 Gene

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