IPO5 Gene
protein-coding GIFtS: 59
GCID: GC13P098605
|
|
importin 5(Previous names: karyopherin (importin) beta 3, RAN binding protein 5 )
(Previous symbols: KPNB3, RANBP5)
| |
Aliases
for IPO5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Importin 51 2 | | Ran-Binding Protein 52 3 | | KPNB31 2 3 | | MGC20681 | | RANBP51 2 3 | | Imp53 | | IMB31 2 | | Importin Beta-3 Subunit2 | | Pse11 2 | | Importin-51 | | Karyopherin (Importin) Beta 31 2 | | Ran_GTP Binding Protein 52 | | RAN Binding Protein 51 2 | | Imp53 | | Importin Subunit Beta-32 3 | | RanBP53 | | Karyopherin Beta-32 3 | | |
Export aliases for IPO5 gene to outside databasesPrevious GC identifers: GC13P097404 GC13P079203 |
Summaries
for IPO5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IPO5:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexesembedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires theNLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alphabinds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of thenuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complexmoves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm withits passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats ofnucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member ofthe importin beta family. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclearlocalization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to thenuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through thepore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin,the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTPhydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distributionof the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear importof ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. Invitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates thenuclear import of HIV-1 Rev
Gene Wiki entry for IPO5 (RANBP5)
|
Genomic Views
for IPO5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IPO5 gene promoter:
Nkx3-1 Nkx3-1 v4 RFX1 Nkx2-2 Nkx3-1 v1 NF-kappaB Nkx3-1 v2 c-Rel Nkx3-1 v3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IPO5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q32.2 Ensembl cytogenetic band: 13q32.2 HGNC cytogenetic band: 13q32.2IPO5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P098605: view genomic region
(about GC identifiers)
Start:
|
98,605,742 bp from pter |
End:
|
98,676,551 bp from pter |
Size:
|
70,810 bases |
Orientation:
|
plus strand |
|
Proteins
for IPO5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410 (See
protein sequence)Recommended Name: Importin-5 Size: 1097 amino acids; 123630 Da
Subunit: Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Binds to HIV-1 Rev
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in thenuclear rim and nucleolus
Sequence caution: Sequence=CAA70103.1; Type=Frameshift; Positions=18;
Secondary accessions: B4DZA0 O15257 Q5T578 Q86XC7Alternative splicing: 3 isoforms: O00410-1 O00410-2 O00410-3 (Ref.2 (CAA70103) sequence differs from that shown due to a frameshift in position 18)Explore the universe of human proteins at neXtProt for IPO5: NX_O00410
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00410
IPO5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002262.3
ENSEMBL proteins: ENSP00000418499 ENSP00000420284 ENSP00000419766 ENSP00000261574 ENSP00000420149 ENSP00000419166 ENSP00000419797 ENSP00000419398 ENSP00000417993 ENSP00000420043 ENSP00000419860 ENSP00000417721 ENSP00000417162 ENSP00000408885 ENSP00000350219 ENSP00000420079 ENSP00000419003 ENSP00000418393 ENSP00000417647 ENSP00000385938 ENSP00000419764 ENSP00000420491 ENSP00000445126
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
IPO5 for ontologies About GeneDecksing
IPO5 Antibody Products:
Assay Products for IPO5: |
Protein
Domains /
Families
for IPO5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IPO5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00410ProtoNet protein and cluster: O00410 UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410Similarity: Belongs to the importin beta familySimilarity: Contains 6 HEAT repeatsSimilarity: Contains 1 importin N-terminal domain |
Function
for IPO5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclearlocalization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to thenuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through thepore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin,the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTPhydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distributionof the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear importof ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. Invitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates thenuclear import of HIV-1 Rev
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPO5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPO5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for IPO5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO5 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IPO5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IPO5:
|
Pathways & Interactions
for IPO5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Spindle assembly and chromosome separation | | | 2 | Development_TGF-beta receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for IPO5
2  GeneGo (Thomson Reuters) Pathways for IPO5
IPO5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IPO5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/899 Interacting proteins for IPO5 (O004101, 2, 3 ENSP000002615744) via UniProtKB, MINT, STRING, and/or I2D (see all 899)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006607 | NLS-bearing substrate import into nucleus |
ISS | -- | | GO:0006610 | ribosomal protein import into nucleus |
IDA | 9687515 | | GO:0006886 | intracellular protein transport |
-- | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- |
IPO5 for ontologies About GeneDecksing
|
Drugs & Compounds
for IPO5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IPO5
1 HMDB Compound for IPO5 About this table
Search CenterWatch for drugs/clinical trials and news about IPO5
|
Transcripts
for IPO5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IPO5 gene: NM_002271.4 Unigene Cluster for IPO5: Importin 5 Hs.712598 [show with all ESTs]Unigene Representative Sequence: NM_00227118/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30): ENST00000477600 ENST00000482642 ENST00000460070 ENST00000481455 ENST00000261574(uc001vne.3)
ENST00000463157 ENST00000493281 ENST00000471898 ENST00000490369 ENST00000489058
ENST00000481689 ENST00000480611 ENST00000485433 ENST00000496368 ENST00000421861
ENST00000357602 ENST00000475420 ENST00000480641
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPO5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPO5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IPO5 (NM_002271) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IPO5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO5 |
Additional cDNA sequence: AB074173.1 AF339834.1 AK125031.1 AK225286.1 AK302812.1 AK303494.1 BC000947.2 BC001497.2 BC019309.1 BC045640.1 BX648222.1 U72761.1 Y08890.1 24/37 DOTS entries (see all 37): DT.95349523 DT.91778875 DT.95323836 DT.449434 DT.100888261 DT.120789096 DT.97858265 DT.100659364 DT.100663616 DT.87077946 DT.120789151 DT.100888257 DT.100888263 DT.120789084 DT.120789163 DT.95367384 DT.120789082 DT.95367386 DT.120789180 DT.120789182 DT.95245454 DT.75167362 DT.99992172 DT.100888254 24/856 AceView cDNA sequences (see all 856): BF437007 CB131884 BP369575 BE206943 BU528527 AA293203 BU156289 BU622336 AI459826 BQ213181 H88998 AI473906 AI829525 AI248209 CA441015 CD519083 BE856974 BP377805 AI093236 CA416362 AU123428 CB250601 AA789227 BM705444
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IPO5 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IPO5
|
Expression
for IPO5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IPO5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGGCAGTA
About this image
See IPO5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IPO5
SOURCE GeneReport for Unigene cluster: Hs.712598
SABiosciences Custom PCR Arrays for IPO5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPO5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPO5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPO5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO5 |
Orthologs
for IPO5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for IPO5 gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
IPO51 |
importin 5 |
82.6(n)
93.6(a) |
|
418783 XM_416978.3 XP_416978.3 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
93(a)82(a) |
many ↔ manymany ↔ many |
3(98154415-98195899) AAWZ02039293(6974-7930) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.77482 |
Xenopus laevis karyopherin-beta 3 variant mRNA, complete more |
78.95(n) |
|
AF468651.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CF348399.12 |
-- |
76.41(n) |
|
368251 CF348399.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Karybeta31 |
Karyopherin beta 3 |
56.95(n)
52.48(a) |
|
40581 NM_079502.2 NP_524226.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
imb-31 |
Protein IMB-3 |
47.53(n)
37.17(a) |
|
3565440 NM_058314.3 NP_490715.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
PSE1(YMR308C)4
PSE11 |
Karyopherin/importin that interacts with the nuclear more4
Pse1p1 |
45.96(n)1
31.67(a)1 |
|
13(892221-888952)4
8553561, 4 NP_014039.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
emb27341 |
armadillo/beta-catenin-like repeat-containing protein |
49.39(n)
38.66(a) |
|
832102 NM_121987.2 NP_197483.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.77422 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
72.56(n) |
|
AK068293.1 |
ENSEMBL Gene Tree for IPO5 (if available)
TreeFam Gene Tree for IPO5 (if available) |
Paralogs
for IPO5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IPO5 gene
- RANBP62
1 SIMAP similar gene for IPO5 using alignment to 22 protein entries: IPO5_HUMAN (see all proteins):RANBP6
IPO5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IPO5
PGOHUM00000234262
|
Genomic Variants
for IPO5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IPO5 (98605742 - 98676551 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IPO5
1 CNV: 71764
1 Indel: 71765 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPO5 |
|
Disorders
/ Diseases
for IPO5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IPO5 for disorders About GeneDecksing
OMIM gene information: 602008
OMIM disorders: --
7  diseases for IPO5: About MalaCardsbipolar disorder hepatitis c influenza hepatitis
schizophrenia immunodeficiency malaria
Human Genome Epidemiology (HuGE) Navigator: IPO5 (3 documents)
Export disorders for IPO5 gene to outside databases
|
Publications
for IPO5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IPO5 gene, integrated from 9 sources (see all 100):
(articles sorted by number of sources associating them with IPO5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of human karyopherin beta3. (PubMed id 9114010)1, 2, 3, 9 Yaseen N.R. and Blobel G. (1997)
- Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. (PubMed id 9271386)1, 2, 3 Deane R.... Bischoff F.R. (1997)
- Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2, 9 Jaekel S. and Goerlich D. (1998)
- Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. (PubMed id 17005651)1, 3 Deng T....Fodor E. (2006)
- Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2 Arnold M.... Kehlenbach R.H. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion. (PubMed id 18562802)1, 9 Chung K.M....Jang S.K. (2008)
- Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3. (PubMed id 10799599)1, 9 Chung K.M....Jang S.K. (2000)
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External Searches for IPO5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing IPO5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing IPO5 gene
(According to HUGE)
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Specialized Databases showing IPO5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for IPO5 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for IPO5 gene:
Search GeneIP for patents involving IPO5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IPO5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPO5 | | | OriGene Protein Over-expression Lysate for IPO5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IPO5 | | OriGene 3'-UTR Clone for IPO5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPO5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPO5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IPO5 | | OriGene Custom Protein Services for IPO5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IPO5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPO5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPO5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPO5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPO5 |
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| | | | Search Tocris compounds for IPO5 |
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 | | | IPO5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO5 |
|  |  |  | | | | ThermoFisher Antibody for IPO5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO5 |
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