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Aliases for IPO5 Gene

Aliases for IPO5 Gene

  • Importin 5 2 3
  • Karyopherin (Importin) Beta 3 2 3
  • Importin Subunit Beta-3 3 4
  • RAN Binding Protein 5 2 3
  • Ran-Binding Protein 5 3 4
  • Karyopherin Beta-3 3 4
  • RANBP5 3 4
  • KPNB3 3 4
  • Imp5 3 4
  • Ran_GTP Binding Protein 5 3
  • Importin Beta-3 Subunit 3
  • Importin-5 3
  • IMB3 3
  • Pse1 3

External Ids for IPO5 Gene

Previous Symbols for IPO5 Gene

  • KPNB3
  • RANBP5

Summaries for IPO5 Gene

Entrez Gene Summary for IPO5 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

GeneCards Summary for IPO5 Gene

IPO5 (Importin 5) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein transporter activity and GTPase inhibitor activity. An important paralog of this gene is RANBP6.

UniProtKB/Swiss-Prot for IPO5 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Wiki entry for IPO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO5 Gene

Genomics for IPO5 Gene

Genomic Location for IPO5 Gene

Start:
97,953,658 bp from pter
End:
98,024,297 bp from pter
Size:
70,640 bases
Orientation:
Plus strand

Genomic View for IPO5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IPO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO5 Gene

Regulatory Elements for IPO5 Gene

Proteins for IPO5 Gene

  • Protein details for IPO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00410-IPO5_HUMAN
    Recommended name:
    Importin-5
    Protein Accession:
    O00410
    Secondary Accessions:
    • B4DZA0
    • O15257
    • Q5T578
    • Q86XC7

    Protein attributes for IPO5 Gene

    Size:
    1097 amino acids
    Molecular mass:
    123630 Da
    Quaternary structure:
    • Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Binds to HIV-1 Rev.
    SequenceCaution:
    • Sequence=CAA70103.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305};

    Alternative splice isoforms for IPO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO5 Gene

Proteomics data for IPO5 Gene at MOPED

Post-translational modifications for IPO5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys548, Lys556, Lys690, and Lys963

No data available for DME Specific Peptides for IPO5 Gene

Domains for IPO5 Gene

Gene Families for IPO5 Gene

HGNC:
  • IPO :Importins

Protein Domains for IPO5 Gene

UniProtKB/Swiss-Prot:

IPO5_HUMAN
Domain:
  • Contains 1 importin N-terminal domain.:
    • O00410
Family:
  • Belongs to the importin beta family. Importin beta-3 subfamily.:
    • O00410
Similarity:
  • Contains 24 HEAT repeats.:
    • O00410
genes like me logo Genes that share domains with IPO5: view

Function for IPO5 Gene

Molecular function for IPO5 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Gene Ontology (GO) - Molecular Function for IPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 9271386
GO:0005488 binding --
GO:0005515 protein binding IPI 10799599
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity ISS --
genes like me logo Genes that share ontologies with IPO5: view

Phenotypes for IPO5 Gene

GenomeRNAi human phenotypes for IPO5:
genes like me logo Genes that share phenotypes with IPO5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IPO5 Gene

Localization for IPO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO5 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO5 Gene COMPARTMENTS Subcellular localization image for IPO5 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005643 nuclear pore TAS 9271386
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with IPO5: view

Pathways for IPO5 Gene

genes like me logo Genes that share pathways with IPO5: view

Pathways by source for IPO5 Gene

Gene Ontology (GO) - Biological Process for IPO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006607 NLS-bearing protein import into nucleus ISS --
GO:0006610 ribosomal protein import into nucleus IDA 9687515
GO:0006886 intracellular protein transport --
GO:0016032 viral process IEA --
GO:0034260 negative regulation of GTPase activity TAS 9271386
genes like me logo Genes that share ontologies with IPO5: view

Compounds for IPO5 Gene

(1) HMDB Compounds for IPO5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with IPO5: view

Transcripts for IPO5 Gene

Unigene Clusters for IPO5 Gene

Importin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for IPO5 Gene

GeneLoc Exon Structure for
IPO5
ECgene alternative splicing isoforms for
IPO5

Expression for IPO5 Gene

mRNA expression in normal human tissues for IPO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO5 Gene

SOURCE GeneReport for Unigene cluster for IPO5 Gene Hs.712598

genes like me logo Genes that share expressions with IPO5: view

Orthologs for IPO5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO5 36
  • 99.74 (n)
  • 100 (a)
IPO5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RANBP6 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO5 36
  • 93.12 (n)
  • 99.52 (a)
IPO5 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo5 36
  • 89.73 (n)
  • 98.27 (a)
Ipo5 16
Ipo5 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ipo5 36
  • 89.78 (n)
  • 98.74 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 92 (a)
OneToMany
IPO5 36
  • 82.65 (n)
  • 93.91 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 93 (a)
ManyToMany
-- 37
  • 83 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.7748 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo5 36
  • 79.08 (n)
  • 90.37 (a)
Str.15322 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
kpnb3 36
  • 74.22 (n)
  • 87.77 (a)
kpnb3 37
  • 87 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003769 36
  • 55.5 (n)
  • 53.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Karybeta3 36
  • 56.91 (n)
  • 52.39 (a)
Karybeta3 37
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea imb-3 36
  • 47.73 (n)
  • 37.46 (a)
imb-3 37
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL349C 36
  • 45.73 (n)
  • 33.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSE1 36
  • 46.12 (n)
  • 32 (a)
PSE1 37
  • 28 (a)
OneToMany
PSE1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14157g 36
  • 45.45 (n)
  • 31.38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2734 36
  • 49.76 (n)
  • 39.21 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2027 36
rice
(Oryza sativa)
Liliopsida Os.7742 36
Os07g0575100 36
  • 49.92 (n)
  • 38.05 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02357 36
  • 48.25 (n)
  • 37.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sal3 36
  • 48.5 (n)
  • 37.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10777 37
  • 53 (a)
OneToMany
Species with no ortholog for IPO5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IPO5 Gene

ENSEMBL:
Gene Tree for IPO5 (if available)
TreeFam:
Gene Tree for IPO5 (if available)

Paralogs for IPO5 Gene

Paralogs for IPO5 Gene

Pseudogenes.org Pseudogenes for IPO5 Gene

genes like me logo Genes that share paralogs with IPO5: view

Variants for IPO5 Gene

Sequence variations from dbSNP and Humsavar for IPO5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs475503 -- 97,981,111(+) CTCTC(C/T)TCGGC intron-variant
rs483117 -- 98,006,427(-) actgc(A/C)ctcca intron-variant
rs484769 -- 97,996,801(-) tcctg(A/G)ctaac intron-variant
rs484770 - 98,006,277(-) CAGTT(C/T)TTTTT missense, reference
rs517676 -- 97,995,552(-) ggtct(C/T)gatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO5 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
esv1006772 CNV Insertion 20482838
esv24236 CNV Loss 19812545

Relevant External Links for IPO5 Gene

HapMap Linkage Disequilibrium report
IPO5

Disorders for IPO5 Gene

Relevant External Links for IPO5

Genetic Association Database (GAD)
IPO5
Human Genome Epidemiology (HuGE) Navigator
IPO5
genes like me logo Genes that share disorders with IPO5: view

No data available for UniProtKB/Swiss-Prot for IPO5 Gene

Publications for IPO5 Gene

  1. Cloning and characterization of human karyopherin beta3. (PMID: 9114010) Yaseen N.R. … Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PMID: 9687515) Jaekel S. … Goerlich D. (EMBO J. 1998) 3 4 23
  3. Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. (PMID: 9271386) Deane R. … Bischoff F.R. (Mol. Cell. Biol. 1997) 2 3 4
  4. Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3. (PMID: 10799599) Chung K.M. … Jang S.K. (J. Virol. 2000) 3 23
  5. A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. (PMID: 16644122) Zhang H. … Shen Y. (Neurosci. Lett. 2006) 3 23

Products for IPO5 Gene

Sources for IPO5 Gene

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