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IPO5 Gene

protein-coding   GIFtS: 60
GCID: GC13P098605

Importin 5

(Previous names: karyopherin (importin) beta 3, RAN binding protein 5)
(Previous symbols: KPNB3, RANBP5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Importin 51 2     IMB32
KPNB31 2 3     Pse12
RANBP51 2 3     imp52
Karyopherin (Importin) Beta 31 2     Importin Beta-3 Subunit2
RAN Binding Protein 51 2     importin-52
Importin Subunit Beta-32 3     Ran_GTP Binding Protein 52
Karyopherin Beta-32 3     Imp53
Ran-Binding Protein 52 3     RanBP53

External Ids:    HGNC: 64021   Entrez Gene: 38432   Ensembl: ENSG000000651507   OMIM: 6020085   UniProtKB: O004103   

Export aliases for IPO5 gene to outside databases

Previous GC identifers: GC13P097404 GC13P079203


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IPO5 Gene:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes
embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires
the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin
alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side
of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran,
the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the
nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta
and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded
by this gene is a member of the importin beta family. (provided by RefSeq, Jul 2008)

GeneCards Summary for IPO5 Gene:
IPO5 (importin 5) is a protein-coding gene. Diseases associated with IPO5 include brain cancer, and hiv-1. GO annotations related to this gene include protein transporter activity and GTPase inhibitor activity. An important paralog of this gene is RANBP6.

UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import
receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In
case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev

Gene Wiki entry for IPO5 (RANBP5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the IPO5 gene promoter:
         Nkx3-1   Nkx3-1 v4   RFX1   Nkx2-2   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   c-Rel   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IPO5 promoter sequence
   Search Chromatin IP Primers for IPO5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IPO5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.2   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q32.2

IPO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P098605:  view genomic region     (about GC identifiers)

Start:
98,605,912 bp from pter      End:
98,676,551 bp from pter
Size:
70,640 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410 (See protein sequence)
Recommended Name: Importin-5  
Size: 1097 amino acids; 123630 Da
Subunit: Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Binds to HIV-1
Rev
Sequence caution: Sequence=CAA70103.1; Type=Frameshift; Positions=18;
Secondary accessions: B4DZA0 O15257 Q5T578 Q86XC7
Alternative splicing: 3 isoforms:  O00410-1   O00410-2   O00410-3   (Ref.2 (CAA70103) sequence differs from that shown due to a frameshift in position 18)

Explore the universe of human proteins at neXtProt for IPO5: NX_O00410

Explore proteomics data for IPO5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys548, Lys556, Lys690, Lys963
  • Modification sites at PhosphoSitePlus

  • See IPO5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002262.3  
    ENSEMBL proteins: 
     ENSP00000420284   ENSP00000419766   ENSP00000261574   ENSP00000419166   ENSP00000419398  
     ENSP00000420149   ENSP00000419797   ENSP00000417993   ENSP00000420043   ENSP00000419860  
     ENSP00000417721   ENSP00000417162   ENSP00000408885   ENSP00000350219   ENSP00000420079  
     ENSP00000419003   ENSP00000418393   ENSP00000417647   ENSP00000385938   ENSP00000419764  
     ENSP00000420491   ENSP00000445126  
    Reactome Protein details: O00410

    IPO5 Human Recombinant Protein Products:

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    Novus Biologicals IPO5 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for IPO5

    IPO5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibody for IPO5
    LSBio Antibodies in human, mouse, rat for IPO5

    IPO5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IPO5
    Cloud-Clone Corp. CLIAs for IPO5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR000357 HEAT
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O00410

    ProtoNet protein and cluster: O00410

    UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410
    Similarity: Belongs to the importin beta family
    Similarity: Contains 6 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    IPO5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO5_HUMAN, O00410
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import
    receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In
    case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity TAS9271386
    GO:0005488binding ----
    GO:0005515protein binding IPI15282309
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ISS--
         
    IPO5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IPO5:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IPO5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPO5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IPO5

    miRNA
    Products:
        
    miRTarBase miRNAs that target IPO5:
    hsa-mir-484 (MIRT041786), hsa-mir-196a-5p (MIRT048251), hsa-mir-877-3p (MIRT036844), hsa-mir-1296-5p (MIRT036092), hsa-mir-16-5p (MIRT051154), hsa-mir-222-3p (MIRT046603), hsa-mir-324-5p (MIRT043188), hsa-mir-93-5p (MIRT048827), hsa-mir-92a-3p (MIRT049490)

    Block miRNA regulation of human, mouse, rat IPO5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPO5 (see all 86):
    hsa-miR-548j hsa-miR-579 hsa-miR-200a hsa-miR-342-3p hsa-miR-3150b-3p hsa-miR-489 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIPO5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IPO5
    Predesigned siRNA for gene silencing in human, mouse, rat IPO5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IPO5

    Clone
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    OriGene clones in human, mouse for IPO5 (see all 8)
    OriGene ORF clones in mouse, rat for IPO5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IPO5 (NM_002271)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IPO5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPO5_HUMAN, O00410: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the
    nuclear rim and nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005643nuclear pore TAS9271386
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA--

    IPO5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IPO5 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82
    vRNP Assembly0.00
    2Disease
    Disease
    3Development TGF beta receptor signaling
    Development TGF beta receptor signaling
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IPO5
        Ran Pathway
    SREBP Proteolysis
    NFAT in Immune Response

    2 GeneGo (Thomson Reuters) Pathways for IPO5
        Cell cycle Spindle assembly and chromosome separation
    Development TGF-beta receptor signaling

    1 Reactome Pathway for IPO5
        vRNP Assembly



    IPO5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IPO5
    Interactions:

        GeneGlobe Interaction Network for IPO5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IPO5 (O004101, 2, 3 ENSP000002615744) via UniProtKB, MINT, STRING, and/or I2D (see all 1106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=5 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=5 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006607NLS-bearing protein import into nucleus ISS--
    GO:0006610ribosomal protein import into nucleus IDA9687515
    GO:0006886intracellular protein transport ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    IPO5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IPO5

    1 HMDB Compound for IPO5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IPO5 gene: 
    NM_002271.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000482642 ENST00000460070 ENST00000481455 ENST00000261574(uc001vne.3)
    ENST00000493281 ENST00000490369 ENST00000463157 ENST00000471898 ENST00000489058
    ENST00000481689 ENST00000480611 ENST00000485433 ENST00000496368 ENST00000421861
    ENST00000357602 ENST00000475420 ENST00000480641 ENST00000490680(uc001vnf.1 uc010tik.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat IPO5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPO5 (see all 86):
    hsa-miR-548j hsa-miR-579 hsa-miR-200a hsa-miR-342-3p hsa-miR-3150b-3p hsa-miR-489 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIPO5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IPO5
    Clone
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    OriGene ORF clones in mouse, rat for IPO5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IPO5 (NM_002271)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO5
    Primer
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    OriGene qPCR primer pairs and template standards for IPO5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IPO5
      QuantiTect SYBR Green Assays in human, mouse, rat IPO5
      QuantiFast Probe-based Assays in human, mouse, rat IPO5

    Selected AceView cDNA sequences (see all 856):

    BF792467 BQ775872 BM808205 CA432738 AW452120 BF793509 BM543898 BQ214299 
    BM472904 BP334576 AA777802 AI655970 BG222500 AA769781 BU179842 AA417261 
    T35294 AA283922 BF437007 AU123609 CF136064 AA844645 AI239903 BF732867 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IPO5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                          -     -     -                                               -                 -                                                   
    SP2:                                                                                      -                 -                                                   
    SP3:                                      -                                                                                                                     
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
    SP1:                                                              -               
    SP2:                                                              -               
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for IPO5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IPO5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCAGTA
    IPO5 Expression
    About this image


    IPO5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    IPO5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IPO5 Protein Expression
        Custom PCR Arrays for IPO5
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IPO5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO5 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo51 , 5 importin 51, 5 89.73(n)1
    98.27(a)1
      14 (64.81 cM)5
    705721  NM_023579.41  NP_076068.11 
     1209111945 
    chicken
    (Gallus gallus)
    Aves IPO51 importin 5 82.65(n)
    93.91(a)
      418783  XM_004938577.1  XP_004938634.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    93(a)
    83(a)
    many ↔ many
    many ↔ many
    3(98154415-98196611)
    AAWZ02039293(6974-8086)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77482 Xenopus laevis karyopherin-beta 3 variant mRNA, complete more 78.95(n)    AF468651.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF348399.12   -- 76.41(n)   368251  CF348399.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Karybeta31 Karyopherin beta 3 56.91(n)
    52.39(a)
      40581  NM_001275330.1  NP_001262259.1 
    worm
    (Caenorhabditis elegans)
    Secernentea imb-31 imb-3 47.73(n)
    37.46(a)
      3565440  NM_058314.4  NP_490715.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSE1(YMR308C)4
    PSE11
    Karyopherin/importin that interacts with the nuclear more4
    PSE11
    46.12(n)1
    32(a)1
      13(892221-888952)4
    8553561, 4  NP_014039.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb27341 emb2734 49.76(n)
    39.21(a)
      832102  NM_121987.2  NP_197483.1 
    rice
    (Oryza sativa)
    Liliopsida Os.77422 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.56(n)    AK068293.1 


    ENSEMBL Gene Tree for IPO5 (if available)
    TreeFam Gene Tree for IPO5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IPO5 gene
    RANBP62  
    1 SIMAP similar gene for IPO5 using alignment to 21 protein entries:     IPO5_HUMAN (see all proteins):
    RANBP6

    IPO5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IPO5
    PGOHUM00000234262


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IPO5 (see all 1546)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596589831,2
    C--79590670(+) TTTTT-/TTT/TTT
    TTTTTTTTT
    AAGAG
    2 -- int1 cds11NA 2
    rs1132632541,2
    F--98603944(+) TCTTCG/ATACAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs761697731,2
    C,F--98603978(+) CAATCG/ACTGAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1868181761,2
    --98603995(+) TCTATA/GTAAAT 1 -- us2k10--------
    rs133789701,2
    C,H--98604013(+) TCAGAC/ACCTTG 1 -- us2k14Minor allele frequency- A:0.00NS EA 392
    rs1120883301,2
    F--98604055(+) ACCTGC/TCCACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs581408501,2
    C,F--98604091(+) AGTAGC/TGAGCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1164437301,2
    F--98604108(+) GTCCCA/GACCAC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1412594831,2
    --98604131(+) GGCAGA/GAGGAT 1 -- us2k10--------
    rs741081091,2
    C,F--98604169(+) CTGGGT/CAACAT 1 -- us2k12Minor allele frequency- C:0.33WA 120

    HapMap Linkage Disequilibrium report for IPO5 (98605912 - 98676551 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IPO5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1006772CNV Insertion20482838
    esv24236CNV Loss19812545
    nsv7246OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IPO5
    DNA2.0 Custom Variant and Variant Library Synthesis for IPO5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602008    OMIM disorders: --

    10 diseases for IPO5:    
    About MalaCards
    brain cancer    hiv-1    bipolar disorder    influenza
    schizophrenia    hepatitis c virus    cystic fibrosis    hepatitis c
    hepatitis    malaria


    IPO5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IPO5
    Human Genome Epidemiology (HuGE) Navigator: IPO5 (3 documents)

    Export disorders for IPO5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IPO5 gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with IPO5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human karyopherin beta3. (PubMed id 9114010)1, 2, 3, 9 Yaseen N.R. and Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. (PubMed id 9271386)1, 2, 3 Deane R.... Bischoff F.R. (Mol. Cell. Biol. 1997)
    3. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2, 9 Jaekel S. and Goerlich D. (EMBO J. 1998)
    4. Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. (PubMed id 17005651)1, 3 Deng T....Fodor E. (J. Virol. 2006)
    5. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2 Arnold M.... Kehlenbach R.H. (J. Biol. Chem. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion. (PubMed id 18562802)1, 9 Chung K.M....Jang S.K. (Mol. Cells 2008)
    10. Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3. (PubMed id 10799599)1, 9 Chung K.M....Jang S.K. (J. Virol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3843 HGNC: 6402 AceView: RANBP5 Ensembl:ENSG00000065150 euGenes: HUgn3843
    ECgene: IPO5 H-InvDB: IPO5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IPO5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IPO5 gene:
    Search GeneIP for patents involving IPO5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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