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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPO5 Gene

protein-coding   GIFtS: 60
GCID: GC13P098605

Importin 5

(Previous names: karyopherin (importin) beta 3, RAN binding protein 5)
(Previous symbols: KPNB3, RANBP5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Importin 51 2     IMB32
KPNB31 2 3     Pse12
RANBP51 2 3     imp52
Karyopherin (Importin) Beta 31 2     Importin Beta-3 Subunit2
RAN Binding Protein 51 2     importin-52
Importin Subunit Beta-32 3     Ran_GTP Binding Protein 52
Karyopherin Beta-32 3     Imp53
Ran-Binding Protein 52 3     RanBP53

External Ids:    HGNC: 64021   Entrez Gene: 38432   Ensembl: ENSG000000651507   OMIM: 6020085   UniProtKB: O004103   

Export aliases for IPO5 gene to outside databases

Previous GC identifers: GC13P097404 GC13P079203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IPO5 Gene:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes
embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires
the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin
alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side
of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran,
the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the
nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta
and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded
by this gene is a member of the importin beta family. (provided by RefSeq, Jul 2008)

GeneCards Summary for IPO5 Gene: 
IPO5 (importin 5) is a protein-coding gene. Diseases associated with IPO5 include bipolar disorder, and influenza, and among its related super-pathways are Development TGF-beta receptor signaling and Cell cycle Spindle assembly and chromosome separation. GO annotations related to this gene include protein transporter activity and Ran GTPase binding. An important paralog of this gene is RANBP6.

UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import
receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In
case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev

Gene Wiki entry for IPO5 (RANBP5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPO5 gene promoter:
         Nkx3-1   Nkx3-1 v4   RFX1   Nkx2-2   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   c-Rel   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IPO5 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPO5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.2   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q32.2

IPO5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P098605:  view genomic region     (about GC identifiers)

Start:
98,605,912 bp from pter      End:
98,676,551 bp from pter
Size:
70,640 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410 (See protein sequence)
Recommended Name: Importin-5  
Size: 1097 amino acids; 123630 Da
Subunit: Binds RPL23A, RPS7 and RPL5. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Binds to HIV-1
Rev
Subcellular location: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the
nuclear rim and nucleolus
Sequence caution: Sequence=CAA70103.1; Type=Frameshift; Positions=18;
Secondary accessions: B4DZA0 O15257 Q5T578 Q86XC7
Alternative splicing: 3 isoforms:  O00410-1   O00410-2   O00410-3   (Ref.2 (CAA70103) sequence differs from that shown due to a frameshift in position 18)

Explore the universe of human proteins at neXtProt for IPO5: NX_O00410

Explore proteomics data for IPO5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00410

  • IPO5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IPO5 Protein Expression
    REFSEQ proteins: NP_002262.3  
    ENSEMBL proteins: 
     ENSP00000420284   ENSP00000419766   ENSP00000261574   ENSP00000419166   ENSP00000419398  
     ENSP00000420149   ENSP00000419797   ENSP00000417993   ENSP00000420043   ENSP00000419860  
     ENSP00000417721   ENSP00000417162   ENSP00000408885   ENSP00000350219   ENSP00000420079  
     ENSP00000419003   ENSP00000418393   ENSP00000417647   ENSP00000385938   ENSP00000419764  
     ENSP00000420491   ENSP00000445126  

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    Cloud-Clone Corp. Proteins for IPO5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005643nuclear pore TAS9271386
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--

    IPO5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR000357 HEAT
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O00410

    ProtoNet protein and cluster: O00410

    UniProtKB/Swiss-Prot: IPO5_HUMAN, O00410
    Similarity: Belongs to the importin beta family
    Similarity: Contains 6 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    IPO5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO5_HUMAN, O00410
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import
    receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In
    case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005095GTPase inhibitor activity TAS9271386
    GO:0005488binding ----
    GO:0005515protein binding IPI15282309
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ISS--
         
    IPO5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IPO5:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IPO5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IPO5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPO5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IPO5 

    miRNA
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    hsa-miR-548j hsa-miR-579 hsa-miR-200a hsa-miR-342-3p hsa-miR-3150b-3p hsa-miR-489 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIPO5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IPO5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development TGF-beta receptor signaling
    Development TGF-beta receptor signaling0.96
    2Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for IPO5
        Cell cycle Spindle assembly and chromosome separation
    Development TGF-beta receptor signaling


    2 GeneGo (Thomson Reuters) Pathways for IPO5
        Cell cycle Spindle assembly and chromosome separation
    Development TGF-beta receptor signaling



    IPO5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IPO5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/937 Interacting proteins for IPO5 (O004101, 2, 3 ENSP000002615744) via UniProtKB, MINT, STRING, and/or I2D (see all 937)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    HIST1H4EP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006607NLS-bearing substrate import into nucleus ISS--
    GO:0006610ribosomal protein import into nucleus IDA9687515
    GO:0006886intracellular protein transport ----
    GO:0019048modulation by virus of host morphology or physiology IEA--

    IPO5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPO5

    1 HMDB Compound for IPO5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about IPO5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IPO5 gene: 
    NM_002271.4  

    Unigene Cluster for IPO5:

    Importin 5
    Hs.712598  [show with all ESTs]
    Unigene Representative Sequence: NM_002271
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000482642 ENST00000460070 ENST00000481455 ENST00000261574(uc001vne.3)
    ENST00000493281 ENST00000490369 ENST00000463157 ENST00000471898 ENST00000489058
    ENST00000481689 ENST00000480611 ENST00000485433 ENST00000496368 ENST00000421861
    ENST00000357602 ENST00000475420 ENST00000480641 ENST00000490680(uc001vnf.1 uc010tik.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO5 (see all 86):
    hsa-miR-548j hsa-miR-579 hsa-miR-200a hsa-miR-342-3p hsa-miR-3150b-3p hsa-miR-489 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIPO5 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO5
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    Additional mRNA sequence: 

    AB074173.1 AF339834.1 AK125031.1 AK225286.1 AK302812.1 AK303494.1 BC000947.2 BC001497.2 
    BC019309.1 BC045640.1 BX648222.1 U72761.1 Y08890.1 

    24/37 DOTS entries (see all 37):

    DT.95349523  DT.91778875  DT.95323836  DT.449434  DT.100888261  DT.120789096  DT.97858265  DT.100659364 
    DT.100663616  DT.87077946  DT.120789151  DT.100888257  DT.100888263  DT.120789084  DT.120789163  DT.95367384 
    DT.120789082  DT.95367386  DT.120789180  DT.120789182  DT.95245454  DT.75167362  DT.99992172  DT.100888254 

    24/856 AceView cDNA sequences (see all 856):

    AA328642 CA432738 BU528527 H13499 BM454304 AA432031 BU633439 BE856974 
    AA281288 BF792467 BG617309 CB853316 AA789227 AA992375 CA416362 BU193354 
    BP344463 BU431221 AI093236 AI829525 BM808205 CA422803 BQ774590 NM_002271 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IPO5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                          -     -     -                                               -                 -                                                   
    SP2:                                                                                      -                 -                                                   
    SP3:                                      -                                                                                                                     
    SP4:                          -     -     -                                                                                                                     
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
    SP1:                                                              -               
    SP2:                                                              -               
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for IPO5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPO5 expression in normal human tissues (normalized intensities)      IPO5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCAGTA
    IPO5 Expression
    About this image


    IPO5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)

    See IPO5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPO5

    SOURCE GeneReport for Unigene cluster: Hs.712598
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO5 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo51 , 5 importin 51, 5 89.73(n)1
    98.27(a)1
      14 (64.81 cM)5
    705721  NM_023579.41  NP_076068.11 
     1209111945 
    chicken
    (Gallus gallus)
    Aves IPO51 importin 5 82.6(n)
    93.6(a)
      418783  XM_416978.3  XP_416978.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    93(a)
    83(a)
    many ↔ many
    many ↔ many
    3(98154415-98196611)
    AAWZ02039293(6974-8086)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77482 Xenopus laevis karyopherin-beta 3 variant mRNA, complete more 78.95(n)    AF468651.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF348399.12   -- 76.41(n)   368251  CF348399.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Karybeta31 Karyopherin beta 3 56.95(n)
    52.48(a)
      40581  NM_079502.2  NP_524226.1 
    worm
    (Caenorhabditis elegans)
    Secernentea imb-31 Protein IMB-3 47.53(n)
    37.17(a)
      3565440  NM_058314.3  NP_490715.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSE1(YMR308C)4
    PSE11
    Karyopherin/importin that interacts with the nuclear more4
    Pse1p1
    45.96(n)1
    31.67(a)1
      13(892221-888952)4
    8553561, 4  NP_014039.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb27341 armadillo/beta-catenin-like repeat-containing protein 49.39(n)
    38.66(a)
      832102  NM_121987.2  NP_197483.1 
    rice
    (Oryza sativa)
    Liliopsida Os.77422 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.56(n)    AK068293.1 


    ENSEMBL Gene Tree for IPO5 (if available)
    TreeFam Gene Tree for IPO5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPO5 gene
    RANBP62  
    1 SIMAP similar gene for IPO5 using alignment to 22 protein entries:     IPO5_HUMAN (see all proteins):
    RANBP6

    IPO5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IPO5
    PGOHUM00000234262


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1546 SNPs in IPO5 are shown (see all 1546)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596589831,2
    C--79590670(+) TTTTT-/TTT/TTT
    TTTTTTTTT
    AAGAG
    2 -- int1 cds11NA 2
    rs1132632541,2
    F--98603944(+) TCTTCG/ATACAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs761697731,2
    C,F--98603978(+) CAATCG/ACTGAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1868181761,2
    --98603995(+) TCTATA/GTAAAT 1 -- us2k10--------
    rs133789701,2
    C,H--98604013(+) TCAGAC/ACCTTG 1 -- us2k14Minor allele frequency- A:0.00NS EA 392
    rs1120883301,2
    F--98604055(+) ACCTGC/TCCACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs581408501,2
    C,F--98604091(+) AGTAGC/TGAGCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1164437301,2
    F--98604108(+) GTCCCA/GACCAC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1412594831,2
    --98604131(+) GGCAGA/GAGGAT 1 -- us2k10--------
    rs741081091,2
    C,F--98604169(+) CTGGGT/CAACAT 1 -- us2k12Minor allele frequency- C:0.33WA 120

    HapMap Linkage Disequilibrium report for IPO5 (98605912 - 98676551 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IPO5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1006772CNV Insertion20482838
    esv24236CNV Loss19812545
    nsv7246OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602008    OMIM disorders: --

    5 diseases for IPO5:    About MalaCards
    bipolar disorder    influenza    schizophrenia    hepatitis c
    hepatitis


    IPO5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IPO5
    Human Genome Epidemiology (HuGE) Navigator: IPO5 (3 documents)

    Export disorders for IPO5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPO5 gene, integrated from 9 sources (see all 116):
    (articles sorted by number of sources associating them with IPO5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human karyopherin beta3. (PubMed id 9114010)1, 2, 3, 9 Yaseen N.R. and Blobel G. (1997)
    2. Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. (PubMed id 9271386)1, 2, 3 Deane R.... Bischoff F.R. (1997)
    3. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. (PubMed id 9687515)1, 2, 9 Jaekel S. and Goerlich D. (1998)
    4. Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. (PubMed id 17005651)1, 3 Deng T....Fodor E. (2006)
    5. Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. (PubMed id 16704975)1, 2 Arnold M.... Kehlenbach R.H. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion. (PubMed id 18562802)1, 9 Chung K.M....Jang S.K. (2008)
    10. Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3. (PubMed id 10799599)1, 9 Chung K.M....Jang S.K. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3843 HGNC: 6402 AceView: RANBP5 Ensembl:ENSG00000065150 euGenes: HUgn3843
    ECgene: IPO5 H-InvDB: IPO5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPO5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IPO5 gene:
    Search GeneIP for patents involving IPO5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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