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IPO4 Gene

protein-coding   GIFtS: 53
GCID: GC14M024649

Importin 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Importin 41 2     ranBP42
Ran-Binding Protein 42 3     IMP4B3
Imp42 3     Imp4b3
imp4b2     Importin-4b3
importin-42     RANBP43
importin-4b2     RanBP43

External Ids:    HGNC: 194261   Entrez Gene: 797112   Ensembl: ENSG000001964977   UniProtKB: Q8TEX93   

Export aliases for IPO4 gene to outside databases

Previous GC identifers: GC14M018436 GC14M022639 GC14M023719 GC14M004764


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IPO4 Gene:
IPO4 (importin 4) is a protein-coding gene. GO annotations related to this gene include Ran GTPase binding.

UniProtKB/Swiss-Prot: IPO4_HUMAN, Q8TEX9
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus
UL84 by recognizing a non-classical NLS

Gene Wiki entry for IPO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IPO4 gene promoter:
         ER-alpha   RFX1   Lmo2   RelA   Nkx2-5   c-Ets-1   GATA-1   HEN1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO4 promoter sequence
   Search Chromatin IP Primers for IPO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IPO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

IPO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024649:  view genomic region     (about GC identifiers)

Start:
24,649,425 bp from pter      End:
24,658,170 bp from pter
Size:
8,746 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IPO4_HUMAN, Q8TEX9 (See protein sequence)
Recommended Name: Importin-4  
Size: 1081 amino acids; 118715 Da
Subunit: Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human
cytomegalovirus UL84. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4
Sequence caution: Sequence=BAB15616.1; Type=Frameshift; Positions=234; Sequence=BAB55421.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAC11174.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAD62595.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: B2RN95 Q2NL96 Q86TZ9 Q8NCG8 Q96SJ3 Q9BTI4 Q9H5L0
Alternative splicing: 2 isoforms:  Q8TEX9-1   Q8TEX9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IPO4: NX_Q8TEX9

Explore proteomics data for IPO4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys81, Lys370, Lys401, Lys788, Lys801, Lys875
  • Modification sites at PhosphoSitePlus

  • See IPO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078934.3  
    ENSEMBL proteins: 
     ENSP00000346453   ENSP00000453708   ENSP00000453108   ENSP00000452798   ENSP00000453825  
     ENSP00000453818   ENSP00000453349   ENSP00000452710  

    IPO4 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IPO4

     
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    Search antibodies-online for proteins for IPO4 

     
    antibodies-online peptides for IPO4

    IPO4 Antibody Products:

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    antibodies-online antibodies for IPO4 (18 products) 

    IPO4 Assay Products:

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    Cloud-Clone Corp. ELISAs for IPO4
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    Search eBioscience for ELISAs for IPO4 
    antibodies-online kits for IPO4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8TEX9

    ProtoNet protein and cluster: Q8TEX9

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: IPO4_HUMAN, Q8TEX9
    Similarity: Belongs to the importin beta family
    Similarity: Contains 6 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    Find genes that share domains with IPO4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO4_HUMAN, Q8TEX9
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus
    UL84 by recognizing a non-classical NLS

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with IPO4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IPO4:
     Decreased viability with pacli 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IPO4

    miRNA
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    miRTarBase miRNAs that target IPO4:
    hsa-mir-92a-3p (MIRT048945), hsa-mir-877-3p (MIRT037189), hsa-mir-940 (MIRT036612), hsa-mir-16-5p (MIRT001450), hsa-let-7b-5p (MIRT001620), hsa-mir-193b-3p (MIRT041255)

    Block miRNA regulation of human, mouse, rat IPO4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate IPO4:
    hsa-miR-9 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidIPO4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: IPO4 (NM_024658)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPO4_HUMAN, Q8TEX9: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005643colocalizes with nuclear pore NAS11823430
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with IPO4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including IPO4: 
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IPO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IPO4 (Q8TEX92, 3 ENSP000003464534) via UniProtKB, MINT, STRING, and/or I2D (see all 468)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628052, 3, ENSP000002893524MINT-7220359 I2D: score=5 STRING: ENSP00000289352
    HIST1H4AP628052, 3MINT-7220359 I2D: score=5 
    HIST1H4BP628052, 3MINT-7220359 I2D: score=5 
    HIST1H4CP628052, 3MINT-7220359 I2D: score=5 
    HIST1H4DP628052, 3MINT-7220359 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0015031protein transport NAS11823430

    Find genes that share ontologies with IPO4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IPO4

    1 HMDB Compound for IPO4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IPO4 gene: 
    NM_024658.3  

    Unigene Cluster for IPO4:

    Importin 4
    Hs.411865  [show with all ESTs]
    Unigene Representative Sequence: NR_051979
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000561090(uc001wmt.1) ENST00000354464 ENST00000561462 ENST00000560798(uc001wmu.2)
    ENST00000558780 ENST00000558046 ENST00000559588 ENST00000560155 ENST00000558233
    ENST00000561199 ENST00000561379 ENST00000560935 ENST00000559253 ENST00000559635
    ENST00000558718 ENST00000558193 ENST00000560315 ENST00000561034
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate IPO4:
    hsa-miR-9 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidIPO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IPO4
    Predesigned siRNA for gene silencing in human, mouse, rat IPO4
    Clone
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    OriGene clones in human, mouse for IPO4 (see all 9)
    OriGene ORF clones in mouse, rat for IPO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IPO4 (NM_024658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO4
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    Primer
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    OriGene qPCR primer pairs and template standards for IPO4
    OriGene qSTAR qPCR primer pairs in human, mouse for IPO4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IPO4
      QuantiTect SYBR Green Assays in human, mouse, rat IPO4
      QuantiFast Probe-based Assays in human, mouse, rat IPO4

    Additional mRNA sequence: 

    AB208897.1 AF411122.1 AK026991.1 AK027871.1 AK056527.1 AK056702.1 AK057044.1 AK057277.1 
    AK074743.1 AK094107.1 AK094897.1 AK095306.1 AK302097.1 AK314305.1 BC003690.1 BC110804.1 
    BC136759.1 BC144399.1 BC144400.1 BX248267.1 CR457367.1 NR_051979.1 

    19 DOTS entries:

    DT.101984522  DT.112651  DT.316366  DT.100882968  DT.95304781  DT.120755380  DT.100882962  DT.100776747 
    DT.97855410  DT.120755383  DT.120755454  DT.95348283  DT.100774519  DT.100882970  DT.120755372  DT.120755387 
    DT.120755400  DT.92449477  DT.91663593 

    Selected AceView cDNA sequences (see all 647):

    BX398908 BU170173 BQ227526 BC003690 BX393958 AI420371 BU186741 BM453288 
    BM047035 BU630261 BI087419 BX339718 AW675564 AK056702 BQ070636 BX161390 
    AA330688 CR625105 CB306204 BM726091 CA417079 AI167659 BU164787 AA303616 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IPO4 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^
    SP1:                                -                                               -     -     -                             -                                 
    SP2:                                -                 -                             -     -     -                             -                                 
    SP3:                                -                                         -     -     -     -     -                       -                                 
    SP4:                                -                                               -     -     -     -                       -                                 
    SP5:                                                                                                                          -                                 

    ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                -                                                                             -     -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for IPO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IPO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATCATACT
    IPO4 Expression
    About this image

    IPO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IPO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411865
        Pathway & Disease-focused RT2 Profiler PCR Array including IPO4: 
              Hepatotoxicity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IPO4
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    QuantiFast Probe-based Assays in human, mouse, rat IPO4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo41 , 5 importin 41, 5 82.93(n)1
    81.94(a)1
      14 (28.19 cM)5
    757511  NM_024267.61  NP_077229.41 
     556254005 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    54(a)
    52(a)
    many → 1
    many → 1
    GL343400.1(22954-46608)
    AAWZ02038369(3504-11698)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ipo41 importin 4 55.27(n)
    47.78(a)
      493373  NM_001008010.2  NP_001008011.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ipo41 importin 4 55.25(n)
    47.63(a)
      553305  XM_679071.6  XP_684163.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321651 CG32165 45.31(n)
    30.43(a)
      59216  NM_168676.2  NP_730182.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP123(YER110C)4
    KAP1231
    Karyopherin beta, mediates nuclear import of ribosomal more4
    KAP1231
    38.47(n)1
    24.95(a)1
      5(382103-378762)4
    8568461, 4  NP_011035.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G276401 AT4G27640 41.11(n)
    29.61(a)
      828875  NM_118900.3  NP_194494.2 


    ENSEMBL Gene Tree for IPO4 (if available)
    TreeFam Gene Tree for IPO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for IPO4 (see all 331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004033931,2
    --24649990(+) ACTCAC/GGGCAG 2 -- int10--------
    rs1438827281,2
    --24650010(+) ACCCCA/GGGTCT 2 -- int10--------
    rs1468892761,2
    --24650043(+) AGTGGC/GAGAAT 2 -- int10--------
    rs71456331,2
    C,F,A,H--24650047(+) GCAGAA/GTCTCT 2 -- int131Minor allele frequency- N:0.00EA NA NS WA CSA 2985
    rs1406469961,2
    C--24650059(+) ATCAGG/TGGGGT 2 -- int10--------
    rs1919518921,2
    --24650061(+) CAGGGC/GGGTGG 2 -- int10--------
    rs1458208661,2
    --24650062(+) AGGGGC/GGTGGT 2 -- int10--------
    rs777255551,2
    C--24650167(+) GGGGAT/CGTGGG 2 -- int13Minor allele frequency- C:0.13CSA WA EA 240
    rs65736011,2
    C,F,H--24650230(+) GAGCTC/TCACCT 2 -- int118Minor allele frequency- T:0.01NS EA NA WA CSA 791
    rs1452220271,2
    --24650344(+) CTGATC/TTGATT 2 -- int10--------

    HapMap Linkage Disequilibrium report for IPO4 (24649425 - 24658170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IPO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1220CNV Insertion18451855
    nsv522667CNV Loss19592680
    nsv901498CNV Loss21882294
    nsv7249OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IPO4
    DNA2.0 Custom Variant and Variant Library Synthesis for IPO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for IPO4:
    Hairy cell leukemia

    Find genes that share disorders with IPO4           About GenesLikeMe


    Export disorders for IPO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IPO4 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with IPO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PubMed id 11823430)1, 2, 3 Jaekel S.... Goerlich D. (EMBO J. 2002)
    2. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PubMed id 22407294)1, 2 Ask K.... Groth A. (EMBO J. 2012)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PubMed id 12610148)1, 2 Lischka P.... Stamminger T. (J. Virol. 2003)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    8. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. (PubMed id 23181366)1 Buanne P....Zambrano N. (J. Proteome Res. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79711 HGNC: 19426 AceView: TM9SF1andIPO4 Ensembl:ENSG00000196497 euGenes: HUgn79711
    ECgene: IPO4 H-InvDB: IPO4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IPO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IPO4 gene:
    Search GeneIP for patents involving IPO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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