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Aliases for IPO4 Gene

Aliases for IPO4 Gene

  • Importin 4 2 3 5
  • Ran-Binding Protein 4 3 4
  • Importin-4b 3 4
  • RanBP4 3 4
  • Imp4b 3 4
  • Imp4 3 4
  • Importin-4 3

External Ids for IPO4 Gene

Previous GeneCards Identifiers for IPO4 Gene

  • GC14M018436
  • GC14M022639
  • GC14M023719
  • GC14M024649
  • GC14M004764

Summaries for IPO4 Gene

GeneCards Summary for IPO4 Gene

IPO4 (Importin 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for IPO4 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for IPO4 Gene

Additional gene information for IPO4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO4 Gene

Genomics for IPO4 Gene

GeneHancer (GH) Regulatory Elements for IPO4 Gene

Promoters and enhancers for IPO4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024187 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 569.3 +0.7 654 2.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 IPO4 NGDN RNA5SP383 KHNYN RNF31 NFATC4 LOC102724814 ENSG00000259321 SDR39U1 SLC22A17
GH14I024270 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 31.4 -83.9 -83862 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LOC102725044 RABGGTA TSSK4 IPO4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1
GH14I024113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.3 +74.1 74124 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 DCAF11 NRL RNF31 NFATC4 IPO4 HOMEZ RNA5SP383 TSSK4 TM9SF1 KHNYN
GH14I024091 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 20.5 +95.3 95317 6.5 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 PCK2 RNA5SP383 NGDN ACIN1 NYNRIN NFATC4 KHNYN IPO4 SLC7A8 TINF2
GH14I023284 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.5 +903.2 903213 3.4 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 HOMEZ PIR53909 ACIN1 PRMT5 IPO4 THTPA TSSK4 NGDN PABPN1 PRMT5-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IPO4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IPO4 gene promoter:

Genomic Locations for IPO4 Gene

Genomic Locations for IPO4 Gene
chr14:24,180,219-24,188,964
(GRCh38/hg38)
Size:
8,746 bases
Orientation:
Minus strand
chr14:24,649,425-24,658,170
(GRCh37/hg19)

Genomic View for IPO4 Gene

Genes around IPO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO4 Gene

Proteins for IPO4 Gene

  • Protein details for IPO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEX9-IPO4_HUMAN
    Recommended name:
    Importin-4
    Protein Accession:
    Q8TEX9
    Secondary Accessions:
    • B2RN95
    • Q2NL96
    • Q86TZ9
    • Q8NCG8
    • Q96SJ3
    • Q9BTI4
    • Q9H5L0

    Protein attributes for IPO4 Gene

    Size:
    1081 amino acids
    Molecular mass:
    118715 Da
    Quaternary structure:
    • Binds with high affinity to RPS3A. The binding is coupled to RanGTP cycles. Binds to human cytomegalovirus UL84. Found in a cytosolic complex with ASF1A, ASF1B, CDAN1 and histones H3.1 and H4.
    SequenceCaution:
    • Sequence=BAB15616.1; Type=Frameshift; Positions=234; Evidence={ECO:0000305}; Sequence=BAB55421.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11174.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD62595.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for IPO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO4 Gene

Post-translational modifications for IPO4 Gene

  • Ubiquitination at posLast=8181, posLast=370370, posLast=401401, posLast=788788, posLast=801801, and posLast=875875

No data available for DME Specific Peptides for IPO4 Gene

Domains & Families for IPO4 Gene

Gene Families for IPO4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for IPO4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TEX9

UniProtKB/Swiss-Prot:

IPO4_HUMAN :
  • Belongs to the importin beta family.
Family:
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with IPO4: view

Function for IPO4 Gene

Molecular function for IPO4 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Phenotypes From GWAS Catalog for IPO4 Gene

Gene Ontology (GO) - Molecular Function for IPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17616579
GO:0008139 nuclear localization sequence binding IBA --
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with IPO4: view
genes like me logo Genes that share phenotypes with IPO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO4 Gene

Localization for IPO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO4 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005643 colocalizes_with nuclear pore NAS 11823430
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with IPO4: view

Pathways & Interactions for IPO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IBA --
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
GO:0006607 NLS-bearing protein import into nucleus IBA --
GO:0006610 ribosomal protein import into nucleus IBA --
genes like me logo Genes that share ontologies with IPO4: view

No data available for Pathways by source and SIGNOR curated interactions for IPO4 Gene

Drugs & Compounds for IPO4 Gene

(2) Drugs for IPO4 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO4: view

Transcripts for IPO4 Gene

Unigene Clusters for IPO4 Gene

Importin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:
SP8: - - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - -
SP12: - - - -
SP13:
SP14:
SP15: - - - -
SP16: - - - - - -
SP17: -
SP18:
SP19:
SP20: -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for IPO4 Gene

GeneLoc Exon Structure for
IPO4
ECgene alternative splicing isoforms for
IPO4

Expression for IPO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IPO4 Gene

Protein differential expression in normal tissues from HIPED for IPO4 Gene

This gene is overexpressed in Bone (54.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPO4 Gene



NURSA nuclear receptor signaling pathways regulating expression of IPO4 Gene:

IPO4

SOURCE GeneReport for Unigene cluster for IPO4 Gene:

Hs.411865

Evidence on tissue expression from TISSUES for IPO4 Gene

  • Nervous system(4.8)
  • Skin(4.5)
genes like me logo Genes that share expression patterns with IPO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IPO4 Gene

Orthologs for IPO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO4 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia IPO4 33 34
  • 89.05 (n)
cow
(Bos Taurus)
Mammalia IPO4 33 34
  • 88.25 (n)
rat
(Rattus norvegicus)
Mammalia Ipo4 33
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Ipo4 33 16 34
  • 82.93 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO4 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo4 33
  • 55.27 (n)
zebrafish
(Danio rerio)
Actinopterygii ipo4 33 34
  • 55.25 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006942 33
  • 48.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32165 33 34
  • 45.31 (n)
CG32164 34
  • 28 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL298C 33
  • 41.32 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20769g 33
  • 39.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP123 33 34 36
  • 38.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27640 33
  • 41.11 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05650 33
  • 45.89 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap123 33
  • 40.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Species where no ortholog for IPO4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO4 Gene

ENSEMBL:
Gene Tree for IPO4 (if available)
TreeFam:
Gene Tree for IPO4 (if available)

Paralogs for IPO4 Gene

No data available for Paralogs for IPO4 Gene

Variants for IPO4 Gene

Sequence variations from dbSNP and Humsavar for IPO4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000071113 -- 24,188,974(-) A/C upstream_transcript_variant
rs1000580318 -- 24,181,495(-) T/A intron_variant
rs1000645038 -- 24,186,527(-) C/T intron_variant
rs1001115645 -- 24,183,732(-) T/C intron_variant
rs1001631235 -- 24,180,429(-) T/C 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IPO4 Gene

Variant ID Type Subtype PubMed ID
nsv1220 CNV insertion 18451855
nsv522667 CNV loss 19592680
nsv7249 OTHER inversion 18451855

Variation tolerance for IPO4 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.63; 95.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IPO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO4 Gene

Disorders for IPO4 Gene

Additional Disease Information for IPO4

No disorders were found for IPO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO4 Gene

Publications for IPO4 Gene

  1. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jäkel S … Görlich D (The EMBO journal 2002) 2 3 4 58
  2. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. (PMID: 22407294) Ask K … Groth A (The EMBO journal 2012) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P … Stamminger T (Journal of virology 2003) 3 4 58

Products for IPO4 Gene

Sources for IPO4 Gene

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