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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPO13 Gene

protein-coding   GIFtS: 55
GCID: GC01P044412

Importin 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Importin 131 2     karyopherin-132
Ran-Binding Protein 132 3     Late Gestation Lung 22
RANBP132 3     Ran Binding Protein 132
IMP132     Imp133
KAP132     KIAA07243
LGL22     Kap133
importin-132     Karyopherin-133
Karyopherin 132     RanBP133

External Ids:    HGNC: 168531   Entrez Gene: 96702   Ensembl: ENSG000001174087   OMIM: 6104115   UniProtKB: O948293   

Export aliases for IPO13 gene to outside databases

Previous GC identifers: GC01P043413 GC01P043842 GC01P043825 GC01P044081 GC01P044185 GC01P042531


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IPO13 Gene:
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates
the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related
nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic
translation initiation factor 1A.(provided by RefSeq, Mar 2009)

GeneCards Summary for IPO13 Gene: 
IPO13 (importin 13) is a protein-coding gene. Diseases associated with IPO13 include rabies, and endometrial carcinoma. GO annotations related to this gene include protein transporter activity and protein binding. An important paralog of this gene is TNPO3.

UniProtKB/Swiss-Prot: IPO13_HUMAN, O94829
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the
paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is
triggered by the loading of import substrates onto IPO13

Gene Wiki entry for IPO13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPO13 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-4   E2F-2   Egr-2   MZF-1   E2F   E2F-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO13 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPO13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

IPO13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO13 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044412:  view genomic region     (about GC identifiers)

Start:
44,412,478 bp from pter      End:
44,433,694 bp from pter
Size:
21,217 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IPO13_HUMAN, O94829 (See protein sequence)
Recommended Name: Importin-13  
Size: 963 amino acids; 108195 Da
Subunit: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAA34444.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB14575.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for IPO13:
2X19 (3D)        2XWU (3D)        3ZJY (3D)    
Secondary accessions: D3DPY4 Q5T4X3 Q7LC04 Q96HS3 Q9H8N3 Q9UFR1

Explore the universe of human proteins at neXtProt for IPO13: NX_O94829

Explore proteomics data for IPO13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94829

  • IPO13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IPO13 Protein Expression
    REFSEQ proteins: NP_055467.3  
    ENSEMBL proteins: 
     ENSP00000361418   ENSP00000361414  

    Human Recombinant Protein Products for IPO13: 
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    Cloud-Clone Corp. Proteins for IPO13 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005643nuclear pore ----
    GO:0005737cytoplasm IEA--

    IPO13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR013598 Exportin-1/Importin-b-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O94829

    ProtoNet protein and cluster: O94829

    2 Blocks protein domains:
    IPB001494 Importin-beta
    IPB013598 Exportin 1-like


    UniProtKB/Swiss-Prot: IPO13_HUMAN, O94829
    Similarity: Belongs to the importin beta family
    Similarity: Contains 20 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    IPO13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO13_HUMAN, O94829
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the
    paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is
    triggered by the loading of import substrates onto IPO13

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    IPO13 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IPO13:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IPO13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IPO13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPO13 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IPO13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for IPO13 (O948291, 2, 3 ENSP000003614184) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632792, 3, ENSP000003248974MINT-8100442 MINT-8108735 MINT-8109281 MINT-8102288 I2D: score=4 STRING: ENSP00000324897
    RANP628262, 3, ENSP000003961274MINT-8107594 MINT-8107327 MINT-8109968 I2D: score=1 STRING: ENSP00000396127
    MAGOHP613262, 3, ENSP000003605254MINT-8109916 MINT-8109339 I2D: score=4 STRING: ENSP00000360525
    ALX1Q156991, 2, 3, ENSP000003154174EBI-747310,EBI-750671 MINT-67873 I2D: score=6 STRING: ENSP00000315417
    EIF1AXP478132, 3, ENSP000003689274MINT-8107594 I2D: score=3 STRING: ENSP00000368927
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IDA15964792
    GO:0006886intracellular protein transport ----

    IPO13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPO13

    1 HMDB Compound for IPO13    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about IPO13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IPO13 gene: 
    NM_014652.3  

    Unigene Cluster for IPO13:

    Importin 13
    Hs.158497  [show with all ESTs]
    Unigene Representative Sequence: NM_014652
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372343(uc001ckx.3) ENST00000489061 ENST00000489773 ENST00000492152
    ENST00000480902 ENST00000372339(uc001cky.3) ENST00000486876
    miRNA
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    hsa-miR-9
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    Additional mRNA sequence: 

    AB018267.1 AF267987.1 AK023441.1 AK091565.1 AK290173.1 AL117501.1 BC002608.2 BC008194.1 

    12 DOTS entries:

    DT.455228  DT.95198422  DT.320929  DT.100647276  DT.121418854  DT.91749327  DT.91912868  DT.95198402 
    DT.100672737  DT.121418880  DT.97857287  DT.99952427 

    24/193 AceView cDNA sequences (see all 193):

    AK091565 CA449978 AB018267 BM928155 BU608700 AL049154 AA593250 AX747063 
    AI082127 BM927330 AF267987 AI081331 BE567364 BM698293 BC008194 AA886266 
    AA346040 BQ933928 BX485820 BF970412 BF594509 NM_014652 BM559524 CA449338 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IPO13 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
    SP1:                                -                                                                                         -                       -         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 22a · 22b · 22c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for IPO13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPO13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAGATTA
    IPO13 Expression
    About this image


    See IPO13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPO13

    SOURCE GeneReport for Unigene cluster: Hs.158497

    UniProtKB/Swiss-Prot: IPO13_HUMAN, O94829
    Tissue specificity: Expressed in fetal brain, heart, intestine and kidney

        SABiosciences Custom PCR Arrays for IPO13
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO13 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo131 , 5 importin 131, 5 93.18(n)1
    99.17(a)1
      4 (53.76 cM)5
    2306731  NM_146152.31  NP_666264.11 
     1178944865 
    chicken
    (Gallus gallus)
    Aves IPO131 importin 13 81.94(n)
    88.31(a)
      424573  NM_001006537.1  NP_001006537.1 
    lizard
    (Anolis carolinensis)
    Reptilia IPO136
    importin 13
    89(a)
    1 ↔ 1
    4(108792606-108851988)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX755476.12   -- 78.64(n)    BX755476.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ipo131 importin 13 75.48(n)
    82.88(a)
      100319138  XM_002665780.2  XP_002665826.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdm1 cadmus 45.63(n)
    29.63(a)
      42171  NM_142425.3  NP_650682.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T16G12.61 Protein T16G12.6 36.3(n)
    22.15(a)
      176420  NM_066834.3  NP_499235.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTR106
    Nuclear import receptor, mediates the nuclear loca...
    17(a)
    1 → many
    XV(633839-636757)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G129301 exportin 1-like protein domain-containing protein 38.68(n)
    27.85(a)
      837851  NM_101164.4  NP_563920.1 


    ENSEMBL Gene Tree for IPO13 (if available)
    TreeFam Gene Tree for IPO13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPO13 gene
    TNPO32  

    IPO13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/440 SNPs in IPO13 are shown (see all 440)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999593741,2
    --42529233(+) CCCCT-/AAAAAC 1 -- us2k10--------
    rs1885518771,2
    C--42529808(+) GTGGCA/GTGATC 1 -- us2k10--------
    rs1414962311,2
    C--42529871(+) CCTCCC/GGAATA 1 -- us2k10--------
    rs1461795221,2
    --42529905(+) CCATGA/CCCGGC 1 -- us2k10--------
    rs1114207261,2
    C,F--42529962(+) AGGATG/AGTCTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1488898191,2
    --42530047(+) GGCCTA/GCTTGC 1 -- us2k10--------
    rs1112674031,2
    C,F--42530061(+) TCTTTG/ATTGAT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1480172871,2
    --42530238(+) CCAATA/GCCAGC 1 -- us2k10--------
    rs1914732251,2
    --42530251(+) CCTCCA/GTTTGA 1 -- us2k10--------
    rs44485531,2
    C,F,A,H--42530286(+) TTTTAG/ATTTTT 1 -- us2k1 tfbs325Minor allele frequency- A:0.43NS EA NA WA CSA 3295

    HapMap Linkage Disequilibrium report for IPO13 (44412478 - 44433694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IPO13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv870606CNV Loss21882294
    nsv870942CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610411    OMIM disorders: --

    4 diseases for IPO13:    About MalaCards
    rabies    endometrial carcinoma    endometriosis    asthma


    IPO13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IPO13
    Human Genome Epidemiology (HuGE) Navigator: IPO13 (2 documents)

    Export disorders for IPO13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPO13 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with IPO13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importin 13: a novel mediator of nuclear import and export. (PubMed id 11447110)1, 2, 3, 9 Mingot J.M....Gorlich D. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    3. Importin-13 genetic variation is associated with impr oved airway responsiveness in childhood asthma. (PubMed id 19619331)1, 4, 9 Raby B.A....Weiss S.T. (2009)
    4. Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation. (PubMed id 21139563)1, 2 Grunwald M. and Bono F. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. (PubMed id 15143176)1, 2 Ploski J.E.... Radu A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung. (PubMed id 10745026)1, 2 Zhang C....Kaplan F. (2000)
    10. Nuclear import mechanism of the EJC component Mago-Y1 4 revealed by structural studies of importin 13. (PubMed id 20122403)2, 9 Bono F....Conti E. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9670 HGNC: 16853 AceView: IPO13 Ensembl:ENSG00000117408 euGenes: HUgn9670
    ECgene: IPO13 H-InvDB: IPO13

    (According to HUGE)
    About This Section
    HUGE: KIAA0724

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPO13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IPO13 gene:
    Search GeneIP for patents involving IPO13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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