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IPO11 Gene

protein-coding   GIFtS: 59
GCID: GC05P061699

Importin 11

  See IPO11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Importin 111 2     importin-112
Ran-Binding Protein 112 3     Ran Binding Protein 112
RanBP112 3     Imp113
RANBP113 5     SLRN5
imp112     

External Ids:    HGNC: 206281   Entrez Gene: 511942   Ensembl: ENSG000000862007   OMIM: 6108895   UniProtKB: Q9UI263   

Export aliases for IPO11 gene to outside databases

Previous GC identifers: GC05P063238 GC05P061670 GC05P061724 GC05P061744 GC05P058664


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IPO11 Gene:
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see
KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000
(PubMed 11032817)).(supplied by OMIM, Sep 2008)

GeneCards Summary for IPO11 Gene:
IPO11 (importin 11) is a protein-coding gene. Diseases associated with IPO11 include triple-a syndrome. GO annotations related to this gene include protein transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot: IPO11_HUMAN, Q9UI26
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)

Gene Wiki entry for IPO11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the IPO11 gene promoter:
         N-Myc   PPAR-alpha   STAT1   STAT2   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO11 promoter sequence
   Search Chromatin IP Primers for IPO11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IPO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12.1

IPO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO11 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P061699:  view genomic region     (about GC identifiers)

Start:
61,699,799 bp from pter      End:
61,924,416 bp from pter
Size:
224,618 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IPO11_HUMAN, Q9UI26 (See protein sequence)
Recommended Name: Importin-11  
Size: 975 amino acids; 112535 Da
Subunit: Interacts with UBE2E3 and RPL12
Secondary accessions: A6NGJ5 B4DZ73 D3DW98 Q8N5R2 Q9NSJ6 Q9NVB1
Alternative splicing: 2 isoforms:  Q9UI26-1   Q9UI26-2   

Explore the universe of human proteins at neXtProt for IPO11: NX_Q9UI26

Explore proteomics data for IPO11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys216
  • Modification sites at PhosphoSitePlus

  • See IPO11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128251.1  NP_057422.3  

    ENSEMBL proteins: 
     ENSP00000427129   ENSP00000395685   ENSP00000425573   ENSP00000316651   ENSP00000427274  
     ENSP00000386992   ENSP00000421517   ENSP00000398230   ENSP00000387039  

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    Cloud-Clone Corp. Proteins for IPO11

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IPO: Importins

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9UI26

    ProtoNet protein and cluster: Q9UI26

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: IPO11_HUMAN, Q9UI26
    Similarity: Belongs to the importin beta family
    Similarity: Contains 15 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    Find genes that share domains with IPO11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO11_HUMAN, Q9UI26
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with IPO11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IPO11:
     Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IPO11

    miRNA
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    miRTarBase miRNAs that target IPO11:
    hsa-mir-16-5p (MIRT032019), hsa-let-7b-5p (MIRT052306)

    Block miRNA regulation of human, mouse, rat IPO11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPO11 (see all 26):
    hsa-miR-548j hsa-miR-520d-5p hsa-miR-548i hsa-miR-202 hsa-miR-570 hsa-miR-23b* hsa-miR-9 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIPO11 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPO11_HUMAN, Q9UI26: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with IPO11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IPO11
    Interactions:

        GeneGlobe Interaction Network for IPO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IPO11 (Q9UI262, 3 ENSP000003869924) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCD4Q9BRC72, 3, ENSP000003886314MINT-67854 I2D: score=5 STRING: ENSP00000388631
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006610ribosomal protein import into nucleus IEA--
    GO:0006886intracellular protein transport ----

    Find genes that share ontologies with IPO11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IPO11

    1 HMDB Compound for IPO11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IPO11 gene (2 alternative transcripts): 
    NM_001134779.1  NM_016338.4  

    Unigene Cluster for IPO11:

    Importin 11
    Hs.482269  [show with all ESTs]
    Unigene Representative Sequence: NM_001134779
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514647 ENST00000424533(uc003jtd.1) ENST00000505902 ENST00000325324(uc003jtc.3 uc011cqr.2)
    ENST00000506200 ENST00000409296 ENST00000506905 ENST00000507640 ENST00000502862
    ENST00000511713 ENST00000511133 ENST00000413749 ENST00000409534(uc003jte.3)
    ENST00000512177
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IPO11 (see all 26):
    hsa-miR-548j hsa-miR-520d-5p hsa-miR-548i hsa-miR-202 hsa-miR-570 hsa-miR-23b* hsa-miR-9 hsa-miR-548a-5p
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    Additional mRNA sequence: 

    AF111109.1 AK001696.1 AK023177.1 AK124969.1 AK302781.1 AL162083.1 BC031694.1 BC033776.1 
    NR_073584.1 

    12 DOTS entries:

    DT.213758  DT.95365546  DT.95230022  DT.91741100  DT.101972504  DT.100745824  DT.120847485  DT.120847522 
    DT.120847594  DT.40195738  DT.99929781  DT.97843884 

    Selected AceView cDNA sequences (see all 64):

    AI284168 AK124969 AW119043 BF445712 AA706755 CK823320 AW088922 BP379020 
    AI369765 BM966917 AI572428 AI127066 AA703162 AA773545 AA369986 AW132063 
    CA444235 BM955693 BQ011304 AI370517 AW268657 AI093745 BX110583 AW241840 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IPO11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^
    SP1:                                                                    -                                                                                   -   
    SP2:                                                                                                                                                  -     -   
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
    SP1:                                            -                           
    SP2:  -     -     -                             -     -                     
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for IPO11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IPO11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTACATAA
    IPO11 Expression
    About this image

    IPO11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IPO11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482269
        Custom PCR Arrays for IPO11
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo111 , 5 importin 111, 5 90.43(n)1
    96.82(a)1
      13 (58.06 cM)5
    765821  NM_029665.31  NP_083941.21 
     1067944395 
    chicken
    (Gallus gallus)
    Aves LRRC701 leucine rich repeat containing 70 79.07(n)
    87.66(a)
      769679  XM_004937267.1  XP_004937324.1 
    lizard
    (Anolis carolinensis)
    Reptilia IPO116
    importin 11
    89(a)
    1 ↔ 1
    2(8139037-8212221)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172032 Transcribed sequence with moderate similarity to protein more 76.19(n)    BX769578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:918971 zgc:91897 72.29(n)
    83.96(a)
      432373  NM_001159661.1  NP_001153133.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp111 Ranbp11 46.4(n)
    37.95(a)
      36732  NM_176177.1  NP_788357.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP120(YPL125W)4 Karyopherin responsible for the nuclear import of ribosome more   --   16(313388-316486) 855978  NP_015200.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G089601 AT3G08960 44.81(n)
    30.72(a)
      820048  NM_111730.5  NP_187508.5 


    ENSEMBL Gene Tree for IPO11 (if available)
    TreeFam Gene Tree for IPO11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IPO11 gene
    1 SIMAP similar gene for IPO11 using alignment to 8 protein entries:     IPO11_HUMAN (see all proteins):
    DKFZp686E10165

    Find genes that share paralogs with IPO11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IPO11 (see all 3307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119976971,2
    C,F--61706594(+) CAAGCG/AATTCT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1493070051,2
    --61706636(+) CAAGCA/GCATGC 1 -- us2k10--------
    rs1143929891,2
    F--61706640(+) CGCATG/ACCACC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1445436901,2
    --61706713(+) CTTGAA/TCTCCT 1 -- us2k10--------
    rs1811200371,2
    --61706727(+) CTCAGG/TTGACC 1 -- us2k10--------
    rs1853254751,2
    --61706737(+) CTGTCC/TGTCTT 1 -- us2k10--------
    rs2018232481,2
    C--61706876(+) TGTTTA/TGGTAA 1 -- us2k10--------
    rs77281661,2
    C,F--61706982(+) tttgaC/Tgttag 1 -- us2k1 tfbs34Minor allele frequency- T:0.11NA WA CSA 124
    rs1138987661,2
    F--61706991(+) AGGTGG/AGCTAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1897408121,2
    --61707113(+) AAACTG/TTACCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IPO11 (61699799 - 61924416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IPO11 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2591326CNV Deletion19546169
    dgv989e201CNV Deletion23290073
    dgv988e201CNV Deletion23290073
    esv2662200CNV Deletion23128226
    esv2660465CNV Deletion23128226
    esv2005948CNV Deletion18987734
    esv273408CNV Insertion20981092
    esv267428CNV Insertion20981092
    nsv329525CNV Insertion16902084
    esv273151CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610889    OMIM disorders: --

    1 disease for IPO11:    
    About MalaCards
    triple-a syndrome

    1 disease from the University of Copenhagen DISEASES database for IPO11:
    triple-A syndrome

    Find genes that share disorders with IPO11           About GenesLikeMe

    Genetic Association Database (GAD): IPO11
    Human Genome Epidemiology (HuGE) Navigator: IPO11 (1 document)

    Export disorders for IPO11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IPO11 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with IPO11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. (PubMed id 11032817)1, 2, 9 Plafker S.M. and Macara I.G. (EMBO J. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. (PubMed id 11809816)1, 9 Plafker S.M. and Macara I.G. (Mol. Cell. Biol. 2002)
    6. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PubMed id 15545318)1, 9 Plafker S.M.... Macara I.G. (J. Cell Biol. 2004)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. (PubMed id 23216389)1 Zuo L....Luo X. (Alcohol. Clin. Exp. Res. 2013)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51194 HGNC: 20628 AceView: IPO11 Ensembl:ENSG00000086200 euGenes: HUgn51194
    ECgene: IPO11 H-InvDB: IPO11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IPO11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IPO11 gene:
    Search GeneIP for patents involving IPO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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