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Aliases for IPO11 Gene

Aliases for IPO11 Gene

  • Importin 11 2 3
  • RanBP11 3 4 6
  • Ran-Binding Protein 11 3 4
  • Imp11 3 4
  • Ran Binding Protein 11 3
  • Importin-11 3
  • SLRN 6

External Ids for IPO11 Gene

Summaries for IPO11 Gene

Entrez Gene Summary for IPO11 Gene

  • Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

GeneCards Summary for IPO11 Gene

IPO11 (Importin 11) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for IPO11 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Gene Wiki entry for IPO11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO11 Gene

Genomics for IPO11 Gene

Genomic Location for IPO11 Gene

Start:
62,403,972 bp from pter
End:
62,628,589 bp from pter
Size:
224,618 bases
Orientation:
Plus strand

Genomic View for IPO11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IPO11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO11 Gene

Regulatory Elements for IPO11 Gene

Proteins for IPO11 Gene

  • Protein details for IPO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI26-IPO11_HUMAN
    Recommended name:
    Importin-11
    Protein Accession:
    Q9UI26
    Secondary Accessions:
    • A6NGJ5
    • B4DZ73
    • D3DW98
    • Q8N5R2
    • Q9NSJ6
    • Q9NVB1

    Protein attributes for IPO11 Gene

    Size:
    975 amino acids
    Molecular mass:
    112535 Da
    Quaternary structure:
    • Interacts with UBE2E3 and RPL12.

    Alternative splice isoforms for IPO11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO11 Gene

Proteomics data for IPO11 Gene at MOPED

Post-translational modifications for IPO11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys216

No data available for DME Specific Peptides for IPO11 Gene

Domains for IPO11 Gene

Gene Families for IPO11 Gene

HGNC:
  • IPO :Importins

Protein Domains for IPO11 Gene

UniProtKB/Swiss-Prot:

IPO11_HUMAN
Domain:
  • Contains 1 importin N-terminal domain.:
    • Q9UI26
Family:
  • Belongs to the importin beta family.:
    • Q9UI26
Similarity:
  • Contains 15 HEAT repeats.:
    • Q9UI26
genes like me logo Genes that share domains with IPO11: view

Function for IPO11 Gene

Molecular function for IPO11 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Gene Ontology (GO) - Molecular Function for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with IPO11: view

Phenotypes for IPO11 Gene

GenomeRNAi human phenotypes for IPO11:
genes like me logo Genes that share phenotypes with IPO11: view

miRNA for IPO11 Gene

miRTarBase miRNAs that target IPO11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IPO11 Gene

Localization for IPO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO11 Gene COMPARTMENTS Subcellular localization image for IPO11 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IPO11: view

Pathways for IPO11 Gene

SuperPathways for IPO11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006610 ribosomal protein import into nucleus IEA --
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with IPO11: view

No data available for Pathways by source for IPO11 Gene

Compounds for IPO11 Gene

(1) HMDB Compounds for IPO11 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with IPO11: view

Transcripts for IPO11 Gene

Unigene Clusters for IPO11 Gene

Importin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
SP1: -
SP2: - - - - -
SP3:
SP4:
SP5:

Relevant External Links for IPO11 Gene

GeneLoc Exon Structure for
IPO11
ECgene alternative splicing isoforms for
IPO11

Expression for IPO11 Gene

mRNA expression in normal human tissues for IPO11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO11 Gene

SOURCE GeneReport for Unigene cluster for IPO11 Gene Hs.482269

genes like me logo Genes that share expressions with IPO11: view

Orthologs for IPO11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO11 36
  • 99.67 (n)
  • 99.8 (a)
IPO11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IPO11 37
  • 98 (a)
OneToOne
LRRC70 36
  • 93.88 (n)
  • 97.85 (a)
dog
(Canis familiaris)
Mammalia IPO11 36
  • 94.09 (n)
  • 98.67 (a)
IPO11 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo11 36
  • 90.43 (n)
  • 96.82 (a)
Ipo11 16
Ipo11 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IPO11 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO11 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo11 36
  • 89.88 (n)
  • 95.77 (a)
chicken
(Gallus gallus)
Aves IPO11 37
  • 90 (a)
OneToOne
LRRC70 36
  • 79.07 (n)
  • 87.66 (a)
lizard
(Anolis carolinensis)
Reptilia IPO11 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo11 36
  • 75.79 (n)
  • 82.97 (a)
Str.17203 36
zebrafish
(Danio rerio)
Actinopterygii IPO11 37
  • 84 (a)
OneToOne
zgc:91897 36
  • 72.29 (n)
  • 83.96 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002970 36
  • 46.72 (n)
  • 39.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp11 36
  • 46.4 (n)
  • 37.95 (a)
Ranbp11 37
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP120 37
  • 25 (a)
OneToOne
KAP120 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08960 36
  • 44.81 (n)
  • 30.72 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02069 36
  • 42.89 (n)
  • 30.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1628 37
  • 34 (a)
OneToOne
Species with no ortholog for IPO11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO11 Gene

ENSEMBL:
Gene Tree for IPO11 (if available)
TreeFam:
Gene Tree for IPO11 (if available)

Paralogs for IPO11 Gene

Selected SIMAP similar genes for IPO11 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with IPO11: view

No data available for Paralogs for IPO11 Gene

Variants for IPO11 Gene

Sequence variations from dbSNP and Humsavar for IPO11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26022 -- 62,503,074(-) gcgga(A/G)gcagg intron-variant
rs26612 -- 62,413,461(+) ATTCT(C/G)AAGCT intron-variant
rs26619 -- 62,472,583(+) agtgc(A/G)atggc intron-variant
rs26621 -- 62,487,320(+) GAACC(C/T)GGGAG intron-variant
rs26622 -- 62,492,533(-) GTTAC(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO11 Gene

Variant ID Type Subtype PubMed ID
dgv1801e1 CNV Complex 17122850
nsv881728 CNV Loss 21882294
essv5631 CNV CNV 17122850
esv35035 CNV Gain 17911159
dgv6078n71 CNV Loss 21882294
nsv10704 CNV Loss 18304495
esv2662200 CNV Deletion 23128226
esv23269 CNV Loss 19812545
nsv881731 CNV Loss 21882294
esv273408 CNV Insertion 20981092
esv2660465 CNV Deletion 23128226
nsv881732 CNV Gain 21882294
dgv6079n71 CNV Loss 21882294
nsv881734 CNV Loss 21882294
nsv328503 CNV Loss 16902084
esv273151 CNV Insertion 20981092
esv267428 CNV Insertion 20981092
nsv329525 CNV Insertion 16902084
nsv881737 CNV Loss 21882294
esv2591326 CNV Deletion 19546169
esv2005948 CNV Deletion 18987734
nsv328501 CNV Loss 16902084
dgv988e201 CNV Deletion 23290073
dgv989e201 CNV Deletion 23290073
nsv4858 CNV Loss 18451855

Relevant External Links for IPO11 Gene

HapMap Linkage Disequilibrium report
IPO11

Disorders for IPO11 Gene

(1) University of Copenhagen DISEASES for IPO11 Gene

Relevant External Links for IPO11

Genetic Association Database (GAD)
IPO11
Human Genome Epidemiology (HuGE) Navigator
IPO11
genes like me logo Genes that share disorders with IPO11: view

No data available for UniProtKB/Swiss-Prot for IPO11 Gene

Publications for IPO11 Gene

  1. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. (PMID: 11032817) Plafker S.M. … Macara I.G. (EMBO J. 2000) 3 4 23
  2. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. (PMID: 11809816) Plafker S.M. … Macara I.G. (Mol. Cell. Biol. 2002) 3 23
  3. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PMID: 15545318) Plafker S.M. … Macara I.G. (J. Cell Biol. 2004) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for IPO11 Gene

Sources for IPO11 Gene

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