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Aliases for IPO11 Gene

Aliases for IPO11 Gene

  • Importin 11 2 3 5
  • Ran-Binding Protein 11 3 4
  • RanBP11 3 4
  • Imp11 3 4
  • Ran Binding Protein 11 3
  • Importin-11 3

External Ids for IPO11 Gene

Previous GeneCards Identifiers for IPO11 Gene

  • GC05P063238
  • GC05P061670
  • GC05P061724
  • GC05P061744
  • GC05P058664
  • GC05P061699

Summaries for IPO11 Gene

Entrez Gene Summary for IPO11 Gene

  • Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

GeneCards Summary for IPO11 Gene

IPO11 (Importin 11) is a Protein Coding gene. GO annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for IPO11 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Gene Wiki entry for IPO11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO11 Gene

Genomics for IPO11 Gene

Regulatory Elements for IPO11 Gene

Enhancers for IPO11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F062376 0.8 ENCODE 12.1 -27.7 -27744 0.2 ATF1 JUN BACH1 ZNF316 NFE2 MAFK NFE2L2 SMARCE1 MTA2 ZNF740 IPO11 DIMT1 KIF2A GC05M062281
GH05F062354 0.6 ENCODE 11.4 -49.7 -49734 0.2 CTCF ZNF654 JUNB TRIM22 REST RAD21 JUND SMC3 NFE2 KIF2A DIMT1 IPO11 GC05M062281
GH05F062720 0.8 Ensembl 4.3 +316.3 316329 0.6 CTCF PKNOX1 TFAP4 MXI1 MAX BMI1 RAD21 ZNF687 MTA2 L3MBTL2 IPO11 PIR51933 IPO11-LRRC70 LRRC70
GH05F062474 0.6 ENCODE 5.5 +71.3 71282 1.1 SMARCE1 ARID1B ZNF362 JUND NCOR1 TAL1 CEBPB FOS IPO11 RNU6-661P CKS1BP3
GH05F062741 0.7 ENCODE 4 +338.6 338642 2.0 SOX13 SAP130 FOXA3 TAL1 CEBPG HMG20A ZNF644 RARA CEBPA SMAD4 IPO11 PIR51933 IPO11-LRRC70 LRRC70
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IPO11 on UCSC Golden Path with GeneCards custom track

Promoters for IPO11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001281449 -72 2601 HDGF CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for IPO11 Gene

Chromosome:
5
Start:
62,403,972 bp from pter
End:
62,628,589 bp from pter
Size:
224,618 bases
Orientation:
Plus strand

Genomic View for IPO11 Gene

Genes around IPO11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO11 Gene

Proteins for IPO11 Gene

  • Protein details for IPO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI26-IPO11_HUMAN
    Recommended name:
    Importin-11
    Protein Accession:
    Q9UI26
    Secondary Accessions:
    • A6NGJ5
    • B4DZ73
    • D3DW98
    • Q8N5R2
    • Q9NSJ6
    • Q9NVB1

    Protein attributes for IPO11 Gene

    Size:
    975 amino acids
    Molecular mass:
    112535 Da
    Quaternary structure:
    • Interacts with UBE2E3 and RPL12.

    Alternative splice isoforms for IPO11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO11 Gene

Post-translational modifications for IPO11 Gene

  • Ubiquitination at Lys 216
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IPO11 Gene

Domains & Families for IPO11 Gene

Gene Families for IPO11 Gene

Protein Domains for IPO11 Gene

Suggested Antigen Peptide Sequences for IPO11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI26

UniProtKB/Swiss-Prot:

IPO11_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family.
  • Contains 15 HEAT repeats.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
Similarity:
  • Contains 15 HEAT repeats.
genes like me logo Genes that share domains with IPO11: view

Function for IPO11 Gene

Molecular function for IPO11 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Gene Ontology (GO) - Molecular Function for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IEA,IBA --
genes like me logo Genes that share ontologies with IPO11: view
genes like me logo Genes that share phenotypes with IPO11: view

Animal Models for IPO11 Gene

MGI Knock Outs for IPO11:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPO11 Gene

Localization for IPO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IPO11 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with IPO11: view

Pathways & Interactions for IPO11 Gene

SuperPathways for IPO11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006610 ribosomal protein import into nucleus IEA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0042991 transcription factor import into nucleus IBA --
genes like me logo Genes that share ontologies with IPO11: view

No data available for Pathways by source and SIGNOR curated interactions for IPO11 Gene

Drugs & Compounds for IPO11 Gene

(2) Drugs for IPO11 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO11: view

Transcripts for IPO11 Gene

Unigene Clusters for IPO11 Gene

Importin 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IPO11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
SP1: -
SP2: - - - - -
SP3:
SP4:
SP5:

Relevant External Links for IPO11 Gene

GeneLoc Exon Structure for
IPO11
ECgene alternative splicing isoforms for
IPO11

Expression for IPO11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IPO11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IPO11 Gene

This gene is overexpressed in Bone (54.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IPO11 Gene



Protein tissue co-expression partners for IPO11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IPO11 Gene:

IPO11

SOURCE GeneReport for Unigene cluster for IPO11 Gene:

Hs.482269
genes like me logo Genes that share expression patterns with IPO11: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPO11 Gene

Orthologs for IPO11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO11 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia IPO11 35
  • 98 (a)
OneToOne
LRRC70 34
  • 93.88 (n)
oppossum
(Monodelphis domestica)
Mammalia IPO11 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO11 34 35
  • 94.09 (n)
mouse
(Mus musculus)
Mammalia Ipo11 34 16 35
  • 90.43 (n)
rat
(Rattus norvegicus)
Mammalia Ipo11 34
  • 89.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IPO11 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPO11 35
  • 90 (a)
OneToOne
LRRC70 34
  • 79.07 (n)
lizard
(Anolis carolinensis)
Reptilia IPO11 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo11 34
  • 75.79 (n)
Str.17203 34
zebrafish
(Danio rerio)
Actinopterygii IPO11 35
  • 84 (a)
OneToOne
zgc:91897 34
  • 72.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002970 34
  • 46.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp11 34 35
  • 46.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP120 35 37
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08960 34
  • 44.81 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02069 34
  • 42.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1628 35
  • 34 (a)
OneToOne
Species where no ortholog for IPO11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO11 Gene

ENSEMBL:
Gene Tree for IPO11 (if available)
TreeFam:
Gene Tree for IPO11 (if available)

Paralogs for IPO11 Gene

(1) SIMAP similar genes for IPO11 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with IPO11: view

No data available for Paralogs for IPO11 Gene

Variants for IPO11 Gene

Sequence variations from dbSNP and Humsavar for IPO11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10039376 -- 62,523,799(+) ATTCA(A/G)AGAGT intron-variant
rs10051492 -- 62,614,059(+) TTTTC(A/G)CATGT intron-variant
rs10054305 -- 62,603,321(+) gttaa(A/G)tcaag intron-variant
rs10055264 -- 62,467,663(+) CCTGG(A/T)AAGGC intron-variant
rs10057981 -- 62,428,684(+) tttag(A/G)gacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO11 Gene

Variant ID Type Subtype PubMed ID
dgv5689n100 CNV gain 25217958
dgv5690n100 CNV gain 25217958
dgv941e201 CNV deletion 23290073
dgv942e201 CNV deletion 23290073
esv2005948 CNV deletion 18987734
esv23269 CNV loss 19812545
esv2591326 CNV deletion 19546169
esv2660465 CNV deletion 23128226
esv2662200 CNV deletion 23128226
esv2759345 CNV gain+loss 17122850
esv2763458 CNV gain 21179565
esv3357380 CNV insertion 20981092
esv3411385 CNV insertion 20981092
esv35035 CNV gain 17911159
esv3575853 CNV gain 25503493
esv3605231 CNV gain 21293372
esv3605236 CNV gain 21293372
esv3605237 CNV loss 21293372
esv3605238 CNV gain 21293372
esv3605239 CNV loss 21293372
esv3605240 CNV gain 21293372
esv3605241 CNV loss 21293372
esv3605243 CNV loss 21293372
esv3894198 CNV gain 25118596
nsv10704 CNV loss 18304495
nsv1074301 CNV deletion 25765185
nsv328501 CNV deletion 16902084
nsv328503 CNV deletion 16902084
nsv329525 CNV insertion 16902084
nsv474336 CNV novel sequence insertion 20440878
nsv4858 CNV deletion 18451855
nsv598348 CNV gain 21841781
nsv930480 CNV deletion 23359205
nsv955846 CNV deletion 24416366
nsv964862 CNV duplication 23825009

Variation tolerance for IPO11 Gene

Residual Variation Intolerance Score: 5.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IPO11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO11 Gene

Disorders for IPO11 Gene

Relevant External Links for IPO11

Genetic Association Database (GAD)
IPO11
Human Genome Epidemiology (HuGE) Navigator
IPO11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO11

No disorders were found for IPO11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO11 Gene

Publications for IPO11 Gene

  1. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. (PMID: 11032817) Plafker S.M. … Macara I.G. (EMBO J. 2000) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PMID: 15545318) Plafker S.M. … Macara I.G. (J. Cell Biol. 2004) 3 22 64

Products for IPO11 Gene

Sources for IPO11 Gene

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