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Aliases for IPO11 Gene

Aliases for IPO11 Gene

  • Importin 11 2 3 5
  • Ran-Binding Protein 11 3 4
  • RanBP11 3 4
  • Imp11 3 4
  • Ran Binding Protein 11 3

External Ids for IPO11 Gene

Previous GeneCards Identifiers for IPO11 Gene

  • GC05P063238
  • GC05P061670
  • GC05P061724
  • GC05P061744
  • GC05P058664
  • GC05P061699

Summaries for IPO11 Gene

Entrez Gene Summary for IPO11 Gene

  • Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]

GeneCards Summary for IPO11 Gene

IPO11 (Importin 11) is a Protein Coding gene. GO annotations related to this gene include binding and Ran GTPase binding.

UniProtKB/Swiss-Prot for IPO11 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Gene Wiki entry for IPO11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO11 Gene

Genomics for IPO11 Gene

Regulatory Elements for IPO11 Gene

Genomic Location for IPO11 Gene

Chromosome:
5
Start:
62,403,972 bp from pter
End:
62,628,589 bp from pter
Size:
224,618 bases
Orientation:
Plus strand

Genomic View for IPO11 Gene

Genes around IPO11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPO11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPO11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO11 Gene

Proteins for IPO11 Gene

  • Protein details for IPO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI26-IPO11_HUMAN
    Recommended name:
    Importin-11
    Protein Accession:
    Q9UI26
    Secondary Accessions:
    • A6NGJ5
    • B4DZ73
    • D3DW98
    • Q8N5R2
    • Q9NSJ6
    • Q9NVB1

    Protein attributes for IPO11 Gene

    Size:
    975 amino acids
    Molecular mass:
    112535 Da
    Quaternary structure:
    • Interacts with UBE2E3 and RPL12.

    Alternative splice isoforms for IPO11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPO11 Gene

Proteomics data for IPO11 Gene at MOPED

Post-translational modifications for IPO11 Gene

  • Ubiquitination at Lys 216
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IPO11 Gene

Domains & Families for IPO11 Gene

Gene Families for IPO11 Gene

Protein Domains for IPO11 Gene

Suggested Antigen Peptide Sequences for IPO11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI26

UniProtKB/Swiss-Prot:

IPO11_HUMAN :
  • Contains 1 importin N-terminal domain.
  • Belongs to the importin beta family.
  • Contains 15 HEAT repeats.
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
Similarity:
  • Contains 15 HEAT repeats.
genes like me logo Genes that share domains with IPO11: view

Function for IPO11 Gene

Molecular function for IPO11 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Gene Ontology (GO) - Molecular Function for IPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with IPO11: view
genes like me logo Genes that share phenotypes with IPO11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPO11 Gene

Localization for IPO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO11 Gene COMPARTMENTS Subcellular localization image for IPO11 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IPO11 Gene

Pathways & Interactions for IPO11 Gene

SuperPathways for IPO11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IPO11 Gene

Drugs & Compounds for IPO11 Gene

(2) Drugs for IPO11 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
MKC-1 Pharma 0
genes like me logo Genes that share compounds with IPO11: view

Transcripts for IPO11 Gene

Unigene Clusters for IPO11 Gene

Importin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^
SP1: - -
SP2: - -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
SP1: -
SP2: - - - - -
SP3:
SP4:
SP5:

Relevant External Links for IPO11 Gene

GeneLoc Exon Structure for
IPO11
ECgene alternative splicing isoforms for
IPO11

Expression for IPO11 Gene

mRNA expression in normal human tissues for IPO11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IPO11 Gene

This gene is overexpressed in Bone (54.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO11 Gene



SOURCE GeneReport for Unigene cluster for IPO11 Gene Hs.482269

genes like me logo Genes that share expression patterns with IPO11: view

Protein tissue co-expression partners for IPO11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IPO11 Gene

Orthologs for IPO11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPO11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC70 35
  • 93.88 (n)
  • 97.85 (a)
IPO11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO11 35
  • 94.09 (n)
  • 98.67 (a)
IPO11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo11 35
  • 90.43 (n)
  • 96.82 (a)
Ipo11 16
Ipo11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IPO11 35
  • 99.67 (n)
  • 99.8 (a)
IPO11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo11 35
  • 89.88 (n)
  • 95.77 (a)
oppossum
(Monodelphis domestica)
Mammalia IPO11 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO11 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC70 35
  • 79.07 (n)
  • 87.66 (a)
IPO11 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO11 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo11 35
  • 75.79 (n)
  • 82.97 (a)
Str.17203 35
zebrafish
(Danio rerio)
Actinopterygii zgc:91897 35
  • 72.29 (n)
  • 83.96 (a)
IPO11 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002970 35
  • 46.72 (n)
  • 39.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp11 35
  • 46.4 (n)
  • 37.95 (a)
Ranbp11 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP120 36
  • 25 (a)
OneToOne
KAP120 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G08960 35
  • 44.81 (n)
  • 30.72 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02069 35
  • 42.89 (n)
  • 30.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1628 36
  • 34 (a)
OneToOne
Species with no ortholog for IPO11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IPO11 Gene

ENSEMBL:
Gene Tree for IPO11 (if available)
TreeFam:
Gene Tree for IPO11 (if available)

Paralogs for IPO11 Gene

(1) SIMAP similar genes for IPO11 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with IPO11: view

No data available for Paralogs for IPO11 Gene

Variants for IPO11 Gene

Sequence variations from dbSNP and Humsavar for IPO11 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35107530 - 62,476,703(-) CACAT(C/T)ATCTG reference, missense
VAR_050005 -
rs26022 -- 62,503,074(-) gcgga(A/G)gcagg intron-variant
rs27751 -- 62,492,899(-) AAAAA(C/T)TGCAA intron-variant
rs27752 -- 62,492,755(-) tttga(A/G)accag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO11 Gene

Variant ID Type Subtype PubMed ID
dgv1801e1 CNV Complex 17122850
nsv881728 CNV Loss 21882294
essv5631 CNV CNV 17122850
esv35035 CNV Gain 17911159
dgv6078n71 CNV Loss 21882294
nsv10704 CNV Loss 18304495
esv2662200 CNV Deletion 23128226
esv23269 CNV Loss 19812545
nsv881731 CNV Loss 21882294
esv273408 CNV Insertion 20981092
esv2660465 CNV Deletion 23128226
nsv881732 CNV Gain 21882294
dgv6079n71 CNV Loss 21882294
nsv881734 CNV Loss 21882294
nsv328503 CNV Loss 16902084
esv273151 CNV Insertion 20981092
esv267428 CNV Insertion 20981092
nsv329525 CNV Insertion 16902084
nsv881737 CNV Loss 21882294
esv2591326 CNV Deletion 19546169
esv2005948 CNV Deletion 18987734
nsv328501 CNV Loss 16902084
dgv988e201 CNV Deletion 23290073
dgv989e201 CNV Deletion 23290073
nsv4858 CNV Loss 18451855

Variation tolerance for IPO11 Gene

Residual Variation Intolerance Score: 5.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPO11 Gene

HapMap Linkage Disequilibrium report
IPO11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO11 Gene

Disorders for IPO11 Gene

Relevant External Links for IPO11

Genetic Association Database (GAD)
IPO11
Human Genome Epidemiology (HuGE) Navigator
IPO11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPO11

No disorders were found for IPO11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPO11 Gene

Publications for IPO11 Gene

  1. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. (PMID: 11032817) Plafker S.M. … Macara I.G. (EMBO J. 2000) 3 4 23 67
  2. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PMID: 15545318) Plafker S.M. … Macara I.G. (J. Cell Biol. 2004) 3 23
  3. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. (PMID: 11809816) Plafker S.M. … Macara I.G. (Mol. Cell. Biol. 2002) 3 23
  4. The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2. (PMID: 25378586) Plafker K.S. … Plafker S.M. (Mol. Biol. Cell 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for IPO11 Gene

Sources for IPO11 Gene

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