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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPO11 Gene

protein-coding   GIFtS: 58
GCID: GC05P061699

Importin 11

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Importin 111 2     importin-112
Ran-Binding Protein 112 3     Ran Binding Protein 112
RanBP112 3     Imp113
RANBP113 5     SLRN5
imp112     

External Ids:    HGNC: 206281   Entrez Gene: 511942   Ensembl: ENSG000000862007   OMIM: 6108895   UniProtKB: Q9UI263   

Export aliases for IPO11 gene to outside databases

Previous GC identifers: GC05P063238 GC05P061670 GC05P061724 GC05P061744 GC05P058664


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IPO11 Gene:
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see
KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000
(PubMed 11032817)).(supplied by OMIM, Sep 2008)

GeneCards Summary for IPO11 Gene: 
IPO11 (importin 11) is a protein-coding gene. Diseases associated with IPO11 include triple-a syndrome. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot: IPO11_HUMAN, Q9UI26
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)

Gene Wiki entry for IPO11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPO11 gene promoter:
         N-Myc   PPAR-alpha   STAT1   STAT2   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPO11 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPO11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q12.1   HGNC cytogenetic band: 5q12.1

IPO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPO11 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P061699:  view genomic region     (about GC identifiers)

Start:
61,699,799 bp from pter      End:
61,924,416 bp from pter
Size:
224,618 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IPO11_HUMAN, Q9UI26 (See protein sequence)
Recommended Name: Importin-11  
Size: 975 amino acids; 112535 Da
Subunit: Interacts with UBE2E3 and RPL12
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A6NGJ5 B4DZ73 D3DW98 Q8N5R2 Q9NSJ6 Q9NVB1
Alternative splicing: 2 isoforms:  Q9UI26-1   Q9UI26-2   

Explore the universe of human proteins at neXtProt for IPO11: NX_Q9UI26

Explore proteomics data for IPO11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UI26

  • IPO11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IPO11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001128251.1  NP_057422.3  

    ENSEMBL proteins: 
     ENSP00000427129   ENSP00000395685   ENSP00000425573   ENSP00000316651   ENSP00000427274  
     ENSP00000386992   ENSP00000421517   ENSP00000398230   ENSP00000387039  

    Human Recombinant Protein Products for IPO11: 
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    Novus Biologicals IPO11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IPO11 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005643nuclear pore ----
    GO:0005737cytoplasm IEA--

    IPO11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IPO: Importins

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9UI26

    ProtoNet protein and cluster: Q9UI26

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB001494 Importin-beta


    UniProtKB/Swiss-Prot: IPO11_HUMAN, Q9UI26
    Similarity: Belongs to the importin beta family
    Similarity: Contains 15 HEAT repeats
    Similarity: Contains 1 importin N-terminal domain


    IPO11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPO11_HUMAN, Q9UI26
    Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear
    localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex
    to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated
    through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds
    to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the
    cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by
    an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By
    similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity IEA--
         
    IPO11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IPO11:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IPO11 
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    SwitchGear 3'UTR luciferase reporter plasmidIPO11 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IPO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/54 Interacting proteins for IPO11 (Q9UI262, 3 ENSP000003869924) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCD4Q9BRC72, 3, ENSP000003886314MINT-67854 I2D: score=5 STRING: ENSP00000388631
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006610ribosomal protein import into nucleus IEA--
    GO:0006886intracellular protein transport ----

    IPO11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPO11

    1 HMDB Compound for IPO11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about IPO11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IPO11 gene (2 alternative transcripts): 
    NM_001134779.1  NM_016338.4  

    Unigene Cluster for IPO11:

    Importin 11
    Hs.482269  [show with all ESTs]
    Unigene Representative Sequence: NM_001134779
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514647 ENST00000424533(uc003jtd.1) ENST00000505902 ENST00000325324(uc003jtc.3 uc011cqr.2)
    ENST00000506200 ENST00000409296 ENST00000506905 ENST00000507640 ENST00000502862
    ENST00000511713 ENST00000511133 ENST00000413749 ENST00000409534(uc003jte.3)
    ENST00000512177
    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IPO11 (see all 26):
    hsa-miR-548j hsa-miR-520d-5p hsa-miR-548i hsa-miR-202 hsa-miR-570 hsa-miR-23b* hsa-miR-9 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidIPO11 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPO11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPO11
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    Additional mRNA sequence: 

    AF111109.1 AK001696.1 AK023177.1 AK124969.1 AK302781.1 AL162083.1 BC031694.1 BC033776.1 
    NR_073584.1 

    12 DOTS entries:

    DT.213758  DT.95365546  DT.95230022  DT.91741100  DT.101972504  DT.100745824  DT.120847485  DT.120847522 
    DT.120847594  DT.40195738  DT.99929781  DT.97843884 

    24/64 AceView cDNA sequences (see all 64):

    AI127066 BQ011304 AW088922 AA369986 AA706755 AI284168 AK124969 BM966917 
    BP379020 AW119043 CK823320 BF445712 AI370517 AI369765 BM955693 AA703162 
    CA444235 AW132063 AI572428 AA773545 AA905797 CA429790 AW297641 BM966924 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IPO11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^
    SP1:                                                                    -                                                                                   -   
    SP2:                                                                                                                                                  -     -   
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c
    SP1:                                            -                           
    SP2:  -     -     -                             -     -                     
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for IPO11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPO11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTACATAA
    IPO11 Expression
    About this image


    See IPO11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPO11

    SOURCE GeneReport for Unigene cluster: Hs.482269
        SABiosciences Custom PCR Arrays for IPO11
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPO11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPO11 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipo111 , 5 importin 111, 5 90.43(n)1
    96.82(a)1
      13 (58.06 cM)5
    765821  NM_029665.31  NP_083941.21 
     1067944395 
    chicken
    (Gallus gallus)
    Aves IPO111 importin 11 80.58(n)
    90.15(a)
      431580  XM_003642950.1  XP_003642998.1 
    lizard
    (Anolis carolinensis)
    Reptilia IPO116
    Uncharacterized protein
    89(a)
    1 ↔ 1
    2(8139037-8212221)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.172032 Transcribed sequence with moderate similarity to protein more 76.19(n)    BX769578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:918971 zgc:91897 72.29(n)
    83.96(a)
      432373  NM_001159661.1  NP_001153133.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp111 CG33139-PA 46.4(n)
    37.95(a)
      36732  NM_176177.1  NP_788357.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAP120(YPL125W)4 Karyopherin responsible for the nuclear import of ribosome more   --   16(313388-316486) 855978  NP_015200.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G089601 armadillo/beta-catenin-like repeat-containing protein 44.89(n)
    30.75(a)
      820048  NM_111730.5  NP_187508.5 


    ENSEMBL Gene Tree for IPO11 (if available)
    TreeFam Gene Tree for IPO11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPO11 gene
    1 SIMAP similar gene for IPO11 using alignment to 8 protein entries:     IPO11_HUMAN (see all proteins):
    DKFZp686E10165

    IPO11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3307 SNPs in IPO11 are shown (see all 3307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0500054
    ----see VAR_0500052 I V mis40--------
    rs1119976971,2
    C,F--61706594(+) CAAGCG/AATTCT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1493070051,2
    --61706636(+) CAAGCA/GCATGC 1 -- us2k10--------
    rs1143929891,2
    F--61706640(+) CGCATG/ACCACC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1445436901,2
    --61706713(+) CTTGAA/TCTCCT 1 -- us2k10--------
    rs1811200371,2
    --61706727(+) CTCAGG/TTGACC 1 -- us2k10--------
    rs1853254751,2
    --61706737(+) CTGTCC/TGTCTT 1 -- us2k10--------
    rs2018232481,2
    C--61706876(+) TGTTTA/TGGTAA 1 -- us2k10--------
    rs77281661,2
    C,F--61706982(+) tttgaC/Tgttag 1 -- us2k1 tfbs34Minor allele frequency- T:0.11NA WA CSA 124
    rs1138987661,2
    F--61706991(+) AGGTGG/AGCTAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for IPO11 (61699799 - 61924416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for IPO11 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2591326CNV Deletion19546169
    dgv989e201CNV Deletion23290073
    dgv988e201CNV Deletion23290073
    esv2662200CNV Deletion23128226
    esv2660465CNV Deletion23128226
    esv2005948CNV Deletion18987734
    esv273408CNV Insertion20981092
    esv267428CNV Insertion20981092
    nsv329525CNV Insertion16902084
    esv273151CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610889    OMIM disorders: --

    2 diseases for IPO11:    About MalaCards
    triple-a syndrome    

    1 disease from the University of Copenhagen DISEASES database for IPO11:
    triple-A syndrome

    IPO11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IPO11
    Human Genome Epidemiology (HuGE) Navigator: IPO11 (1 document)

    Export disorders for IPO11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPO11 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with IPO11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. (PubMed id 11032817)1, 2, 9 Plafker S.M. and Macara I.G. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. (PubMed id 11809816)1, 9 Plafker S.M. and Macara I.G. (2002)
    6. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PubMed id 15545318)1, 9 Plafker S.M.... Macara I.G. (2004)
    7. Genome-wide significant association signals in IPO11-H TR1A region specific for alcohol and nicotine codependence. (PubMed id 23216389)1 Zuo L....Luo X. (2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51194 HGNC: 20628 AceView: IPO11 Ensembl:ENSG00000086200 euGenes: HUgn51194
    ECgene: IPO11 H-InvDB: IPO11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPO11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IPO11 gene:
    Search GeneIP for patents involving IPO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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