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Aliases for IPMK Gene

Aliases for IPMK Gene

  • Inositol Polyphosphate Multikinase 2 3 5
  • Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase 4
  • EC 2.7.1.151 4
  • IMPK 4

External Ids for IPMK Gene

Previous GeneCards Identifiers for IPMK Gene

  • GC10M059625
  • GC10M059951
  • GC10M053944

Summaries for IPMK Gene

Entrez Gene Summary for IPMK Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

GeneCards Summary for IPMK Gene

IPMK (Inositol Polyphosphate Multikinase) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Metabolism. GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol tetrakisphosphate 3-kinase activity. An important paralog of this gene is IP6K2.

UniProtKB/Swiss-Prot for IPMK Gene

  • Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPMK Gene

Genomics for IPMK Gene

Regulatory Elements for IPMK Gene

Enhancers for IPMK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IPMK on UCSC Golden Path with GeneCards custom track

Promoters for IPMK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IPMK on UCSC Golden Path with GeneCards custom track

Genomic Location for IPMK Gene

Chromosome:
10
Start:
58,191,517 bp from pter
End:
58,267,937 bp from pter
Size:
76,421 bases
Orientation:
Minus strand

Genomic View for IPMK Gene

Genes around IPMK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPMK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPMK Gene

Proteins for IPMK Gene

  • Protein details for IPMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU5-IPMK_HUMAN
    Recommended name:
    Inositol polyphosphate multikinase
    Protein Accession:
    Q8NFU5

    Protein attributes for IPMK Gene

    Size:
    416 amino acids
    Molecular mass:
    47222 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IPMK Gene

Proteomics data for IPMK Gene at MOPED

Post-translational modifications for IPMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IPMK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IPMK Gene

Domains & Families for IPMK Gene

Protein Domains for IPMK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IPMK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFU5

UniProtKB/Swiss-Prot:

IPMK_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IPMK: view

No data available for Gene Families for IPMK Gene

Function for IPMK Gene

Molecular function for IPMK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
UniProtKB/Swiss-Prot Function:
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).

Enzyme Numbers (IUBMB) for IPMK Gene

Gene Ontology (GO) - Molecular Function for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000824 inositol tetrakisphosphate 3-kinase activity IEA,TAS --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with IPMK: view
genes like me logo Genes that share phenotypes with IPMK: view

Animal Models for IPMK Gene

MGI Knock Outs for IPMK:

Animal Model Products

  • Taconic Biosciences Mouse Models for IPMK

miRNA for IPMK Gene

miRTarBase miRNAs that target IPMK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IPMK Gene

Localization for IPMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPMK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPMK Gene COMPARTMENTS Subcellular localization image for IPMK gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IPMK Gene

Pathways & Interactions for IPMK Gene

genes like me logo Genes that share pathways with IPMK: view

Interacting Proteins for IPMK Gene

Gene Ontology (GO) - Biological Process for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with IPMK: view

No data available for SIGNOR curated interactions for IPMK Gene

Drugs & Compounds for IPMK Gene

(3) Drugs for IPMK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(6) Additional Compounds for IPMK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 1,4,5,6-tetrakisphosphate
  • D-Myo-Inositol 1,4,5,6-tetrakisphosphate
  • Inositol 1,4,5,6-tetrakisphosphate
121010-58-0
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Inositol 1,3,4,5,6-pentakisphosphate
  • 1D-Myo-Inositol 1,3,4,5,6-pentakisphosphate
  • Inositol 1,3,4,5,6-pentaphosphate
  • Inositol pentaphosphate
  • Myo-Inositol 1,3,4,5,6-pentakis(phosphate)
  • Myo-Inositol 1,3,4,5,6-pentaphosphate
20298-95-7
Inositol 1,4,5-trisphosphate
  • 1D-Myo-Inositol 1,4,5-trisphosphate
  • D-Myo-Inositol 1,4,5-trisphosphate
  • Inositol 1,4,5-trisphosphate
88269-39-0
genes like me logo Genes that share compounds with IPMK: view

Transcripts for IPMK Gene

mRNA/cDNA for IPMK Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IPMK Gene

Inositol polyphosphate multikinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPMK Gene

No ASD Table

Relevant External Links for IPMK Gene

GeneLoc Exon Structure for
IPMK
ECgene alternative splicing isoforms for
IPMK

Expression for IPMK Gene

mRNA expression in normal human tissues for IPMK Gene

mRNA differential expression in normal tissues according to GTEx for IPMK Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for IPMK Gene

This gene is overexpressed in Esophagus (26.8), Fetal testis (15.5), and Fetal heart (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPMK Gene



SOURCE GeneReport for Unigene cluster for IPMK Gene Hs.30280

mRNA Expression by UniProt/SwissProt for IPMK Gene

Q8NFU5-IPMK_HUMAN
Tissue specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
genes like me logo Genes that share expression patterns with IPMK: view

Protein tissue co-expression partners for IPMK Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IPMK Gene

Orthologs for IPMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPMK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IPMK 35
  • 92.47 (n)
  • 91.59 (a)
IPMK 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipmk 35
  • 80.98 (n)
  • 84.6 (a)
Ipmk 16
Ipmk 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IPMK 35
  • 99.6 (n)
  • 99.52 (a)
IPMK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipmk 35
  • 80.98 (n)
  • 86.62 (a)
oppossum
(Monodelphis domestica)
Mammalia IPMK 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPMK 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves IPMK 35
  • 75.52 (n)
  • 80.47 (a)
IPMK 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPMK 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipmk 35
  • 68.14 (n)
  • 67.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1741 35
zebrafish
(Danio rerio)
Actinopterygii ipmkb 35
  • 61.11 (n)
  • 63.22 (a)
ipmka 36
  • 58 (a)
OneToMany
ipmkb 36
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012099 35
  • 44.44 (n)
  • 30.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ipk2 35
  • 48.12 (n)
  • 40.73 (a)
Ipk2 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_ZK795.1 35
  • 47.5 (n)
  • 33.05 (a)
ZK795.1 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 36
  • 7 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons IPK2a 35
  • 44.07 (n)
  • 31.25 (a)
rice
(Oryza sativa)
Liliopsida Os02g0523800 35
  • 38.12 (n)
  • 27.78 (a)
Species with no ortholog for IPMK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IPMK Gene

ENSEMBL:
Gene Tree for IPMK (if available)
TreeFam:
Gene Tree for IPMK (if available)

Paralogs for IPMK Gene

Paralogs for IPMK Gene

Pseudogenes.org Pseudogenes for IPMK Gene

genes like me logo Genes that share paralogs with IPMK: view

Variants for IPMK Gene

Sequence variations from dbSNP and Humsavar for IPMK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2275443 - 58,196,280(+) TGTGA(C/T)ATGCT reference, missense
rs1582159 -- 58,248,946(+) GACAC(A/G)TAGGT intron-variant
rs1618814 -- 58,203,716(+) gaaca(A/G)tttag intron-variant
rs1619597 -- 58,203,797(+) tactg(C/T)gggta intron-variant
rs1625716 -- 58,200,322(-) GGCCA(A/C)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPMK Gene

Variant ID Type Subtype PubMed ID
nsv895559 CNV Loss 21882294
nsv895560 CNV Loss 21882294

Variation tolerance for IPMK Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IPMK Gene

HapMap Linkage Disequilibrium report
IPMK
Human Gene Mutation Database (HGMD)
IPMK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPMK Gene

Disorders for IPMK Gene

Relevant External Links for IPMK

Genetic Association Database (GAD)
IPMK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPMK

No disorders were found for IPMK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPMK Gene

Publications for IPMK Gene

  1. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (PMID: 12027805) Nalaskowski M.M. … Mayr G.W. (Biochem. J. 2002) 2 3 4 23 67
  2. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. (PMID: 12223481) Chang S.-C. … Majerus P.W. (J. Biol. Chem. 2002) 2 3 23
  3. Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. (PMID: 17981594) Resnick A.C. … Saiardi A. (Front. Biosci. 2008) 3 23
  4. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. (PMID: 16247451) Morgan-Lappe S. … Leverson J.D. (Oncogene 2006) 3 23
  5. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. (PMID: 16293229) Chang S.C. … Majerus P.W. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for IPMK Gene

Sources for IPMK Gene

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