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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPMK Gene

protein-coding   GIFtS: 49
GCID: GC10M059951

inositol polyphosphate multikinase
  Search for IPMK
in
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our new
 Human Malady Compendium 
Biological research products
for IPMK    

Aliases
for IPMK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inositol Polyphosphate Multikinase1 2
Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase2 3
EC 2.7.1.1513
IMPK3

External Ids:    HGNC: 207391   Entrez Gene: 2534302   Ensembl: ENSG000001511517   OMIM: 6098515   UniProtKB: Q8NFU53   

Export aliases for IPMK gene to outside databases

Previous GC identifers: GC10M059625 GC10M053944


Summaries
for IPMK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IPMK:
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and
6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the
biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role
in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of
chromosome 19. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
Function: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol
1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4)




Genomic Views
for IPMK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPMK gene promoter:
         Pbx1a   p53   AML1a   CUTL1   Tal-1beta   Cdc5   E47   ZIC2/Zic2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IPMK promoter sequence
   Search SABiosciences Chromatin IP Primers for IPMK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPMK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q21.1

IPMK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPMK gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M059951:  view genomic region     (about GC identifiers)

Start:
 59,951,278 bp from pter      End:
 60,027,694 bp from pter
Size:
 76,417 bases      Orientation:
 minus strand

Proteins
for IPMK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5 (See protein sequence)
Recommended Name: Inositol polyphosphate multikinase  
Size: 416 amino acids; 47222 Da
Subcellular location: Nucleus

Explore the universe of human proteins at neXtProt for IPMK: NX_Q8NFU5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NFU5

    • IPMK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689416.1  
    ENSEMBL proteins: 
     ENSP00000363046  
    Reactome Protein details: Q8NFU5
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: IPMK
    OriGene Protein Over-expression Lysate: IPMK
    OriGene Custom Protein Services for IPMK 
    GenScript Custom Purified and Recombinant Proteins Services for IPMK
    Novus Biologicals IPMK Proteins
    Novus Biologicals IPMK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IPMK

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    IPMK for ontologies           About GeneDecksing



    IPMK Antibody Products: 
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    ThermoFisher Antibody for IPMK

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    Uscn ELISAs and CLIAs for IPMK

    Protein Domains /
    Families
    for IPMK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IPMK for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005522 IPK

    Graphical View of Domain Structure for InterPro Entry Q8NFU5

    ProtoNet protein and cluster: Q8NFU5

    UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
    Similarity: Belongs to the inositol phosphokinase (IPK) family


    Function
    for IPMK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
    Function: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol
    1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4)
    Catalytic activity: 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

    Enzyme Number (IUBMB): EC 2.7.1.1511

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IPMK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPMK
    8/125 QIAGEN miScript miRNA Assays for microRNAs that regulate IPMK (see all 125):
    hsa-miR-548j hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-128 hsa-miR-485-3p hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: IPMK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPMK (see all 7)
    OriGene shRNA RFP: IPMK
    OriGene siRNA: IPMK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPMK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IPMK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPMK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPMK
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    GenScript: all cDNA clones in your preferred vector: IPMK (NM_152230)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPMK 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IPMK
    Search LifeMap BioReagents cell lines for IPMK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPMK

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000823inositol-1,4,5-trisphosphate 6-kinase activity IEA--
    GO:0000824inositol tetrakisphosphate 3-kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity IEA--


    IPMK for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for IPMK:
     Decreased CYP1A1 activity afte  Decreased Wnt reporter activit  Decreased cilium length after   Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-out Ipmktm1Yrk for IPMK
         5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ipmk):
     embryogenesis  growth/size  mortality/aging  nervous system  no phenotypic analysis 

    IPMK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IPMK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis
    		D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis1.00
    		1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)0.67
    		D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis0.67
    2D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    		D-myo-inositol (1,3,4)-trisphosphate biosynthesis1.00
    		superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.75
    		1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.76
    3inositol pyrophosphates biosynthesis
    		inositol pyrophosphates biosynthesis1.00
    		Synthesis of IPs in the nucleus0.57
    4Inositol phosphate metabolism
    		Inositol phosphate metabolism1.00
    		superpathway of inositol phosphate compounds0.59
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8 BioSystems Pathways for IPMK (see all 8) 
        1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
    inositol pyrophosphates biosynthesis
    D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis

    3        Reactome Pathways for IPMK
        Synthesis of IPs in the nucleus
    Metabolism
    Inositol phosphate metabolism


    1         Kegg Pathway  (Kegg details for IPMK):
        Inositol phosphate metabolism


    IPMK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IPMK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for IPMK (Q8NFU53 ENSP000003630464) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUT8Q9BYC53I2D: score=4 
    NOP58Q9Y2X33I2D: score=4 
    ST13P505023I2D: score=1 
    INPP5AENSP000003575834STRING: ENSP00000357583
    INPP5DENSP000003525754STRING: ENSP00000352575
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001841neural tube formation IEA--
    GO:0032958inositol phosphate biosynthetic process IEA--


    IPMK for ontologies           About GeneDecksing



    Drugs & Compounds
    for IPMK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IPMK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPMK

    5 HMDB Compounds for IPMK    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4,5,6-tetrakisphosphateD-myo-Inositol 1,4,5,6-tetrakisphosphate (see all 3)121010-58-0--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Inositol 1,3,4,5,6-pentakisphosphate1D-myo-Inositol 1,3,4,5,6-pentakisphosphate (see all 5)20298-95-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--
    4 Novoseek chemical compound relationships for IPMK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,6-tetrakisphosphate 95.7 3 12223481 (2), 16293229 (1)
    inositol 1,3,4,5-tetrakisphosphate 81.3 1 16293229 (1)
    inositol 1,4,5 trisphosphate 60.1 5 15659385 (2), 16293229 (1)
    inositol 52.8 4 15659385 (1), 12027805 (1)

    Search CenterWatch for drugs/clinical trials and news about IPMK 

    Transcripts
    for IPMK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IPMK gene: 
    NM_152230.4  

    Unigene Cluster for IPMK:

    Inositol polyphosphate multikinase
    Hs.30280  [show with all ESTs]
    Unigene Representative Sequence: NM_152230
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373935(uc001jkb.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IPMK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPMK
    8/125 QIAGEN miScript miRNA Assays for microRNAs that regulate IPMK (see all 125):
    hsa-miR-548j hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-128 hsa-miR-485-3p hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: IPMK 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPMK (see all 7)
    OriGene shRNA RFP: IPMK
    OriGene siRNA: IPMK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPMK
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IPMK (NM_152230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPMK 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPMK

    Additional cDNA sequence: 

    AF432853.1 AK096839.1 BC016612.1 BC065709.1 

    3 DOTS entries:

    DT.40207909  DT.408134  DT.102826332 

    24/30 AceView cDNA sequences (see all 30):

    BU167197 BC065709 BK000580 AF432853 AK096839 AI478349 BQ439197 NM_152230 
    BE887612 BU928323 BX502197 CD637634 BX101471 BG258567 BV189718 BC016612 
    BX497598 AA974259 BE242273 CD637637 AI650448 AI336916 CD637628 CD637626 

    GeneLoc Exon Structure


    Expression
    for IPMK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPMK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IPMK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPMK

    SOURCE GeneReport for Unigene cluster: Hs.30280

    UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
    Tissue specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood
    leukocytes, kidney, spleen and colon

        SABiosciences Expression via Pathway-Focused PCR Array including IPMK: 
              Nephrotoxicity in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPMK

    Orthologs
    for IPMK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPMK gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ipmk1 , 5 inositol polyphosphate multikinase1, 5 80.89(n)1
    84.6(a)1    		   10 (36.89 cM)5
    697181  NM_027184.11  NP_081460.11 
     713477635 
    chicken
    (Gallus gallus)    		 Aves IPMK6
    		 Uncharacterized protein
    		 79(a)
    		 1 ↔ 1
    		 6(6330100-6361370)
    lizard
    (Anolis carolinensis)    		 Reptilia IPMK6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343378.1(140027-164572)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.17412 Xenopus laevis transcribed sequences 76.84(n)    BG551900.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ipmkb1 inositol polyphosphate multikinase b 61.11(n)
    63.22(a)    		   790916  NM_001080064.1  NP_001073533.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ipk21 CG13688-PA 47.48(n)
    36.79(a)    		   33236  NM_134691.1  NP_608535.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_ZK795.11 Protein ZK795.1 47.8(n)
    33.96(a)    		   191426  NM_070001.2  NP_502402.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons IPK2a1 inositol polyphosphate multikinase alpha 44.07(n)
    31.25(a)    		   830628  NM_180455.2  NP_850786.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g05238001 hypothetical protein 37.28(n)
    27.49(a)    		   4329509  NM_001053521.1  NP_001046986.1 


    ENSEMBL Gene Tree for IPMK (if available)
    TreeFam Gene Tree for IPMK (if available) 

    Paralogs
    for IPMK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPMK gene
    IP6K32  IP6K12  IP6K22  

    IPMK for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IPMK
    PGOHUM00000248329 PGOHUM00000234187


    Genomic Variants
    for IPMK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1329 NCBI SNPs in IPMK are shown (see all 1329)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1995619591,2
    		--59950794(+) ACATG-/TTTTTT 1 -- ds50010--------
    rs1863201451,2
    		--59950883(+) ACTAAC/TTTCTG 1 -- ds50010--------
    rs1476455991,2
    		--59951028(+) AAAGAC/TTTGTT 1 -- ds50010--------
    rs1422295071,2
    		--59951258(+) AGCATA/GTTACA 1 -- ds50010--------
    rs798745041,2
    		F,--59951311(+) TCAAAT/CATACA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1913632821,2
    		--59951313(+) AAATAC/TACAGT 1 -- ut310--------
    rs1444124161,2
    		--59951403(+) ACATTA/GACAAT 1 -- ut310--------
    rs1508645501,2
    		C,--59951461(+) CATTT-/ATAAAA 1 -- ut310--------
    rs579266831,2
    		C--59951462(+) AAAAA-/ACCCTA 1 -- ut310--------
    rs1827873011,2
    		--59951535(+) AAGTAC/GAATAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IPMK (59951278 - 60027694 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IPMK: --

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    Disorders / Diseases
    for IPMK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IPMK for disorders           About MalaCards

    IPMK for disorders           About GeneDecksing

    OMIM gene information: 609851    OMIM disorders: --


    Export disorders for IPMK gene to outside databases

    Publications
    for IPMK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPMK gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with IPMK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (PubMed id 12027805)1, 2, 3, 9 Nalaskowski M.M....Mayr G.W. (2002)
    2. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. (PubMed id 12223481)1, 2, 3, 9 Chang S.-C.... Majerus P.W. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. (PubMed id 15659385)1, 9 Mayr G.W....Hillemeier K. (2005)
    5. Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. (PubMed id 17981594)1, 9 Resnick A.C. and Saiardi A. (2008)
    6. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. (PubMed id 16293229)1, 9 Chang S.C. and Majerus P.W. (2006)
    7. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. (PubMed id 16247451)1, 9 Morgan-Lappe S....Leverson J.D. (2006)
    8. Inositol polyphosphate multikinase signaling in the re gulation of metabolism. (PubMed id 23050966)1 Lee J.Y....Kim S. (2012)
    9. Direct modification and activation of a nuclear recept or-PIP_2 complex by the inositol lipid kinase IPMK. (PubMed id 22715467)1 Blind R.D....Ingraham H.A. (2012)
    10. Nucleocytoplasmic shuttling of human inositol phosphat e multikinase is influenced by CK2 phosphorylation. (PubMed id 22718630)1 Meyer R....Mayr G.W. (2012)

    External Searches for IPMK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IPMK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253430 HGNC: 20739 AceView: IPMK Ensembl:ENSG00000151151 euGenes: HUgn253430
    ECgene: IPMK Kegg: 253430 H-InvDB: IPMK

    Other Databases showing IPMK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IPMK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPMK Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IPMK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IPMK gene:
    Search GeneIP for patents involving IPMK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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