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Aliases for IPMK Gene

Aliases for IPMK Gene

  • Inositol Polyphosphate Multikinase 2 3
  • Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase 4
  • EC 2.7.1.151 4
  • IMPK 4

External Ids for IPMK Gene

Summaries for IPMK Gene

Entrez Gene Summary for IPMK Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

GeneCards Summary for IPMK Gene

IPMK (Inositol Polyphosphate Multikinase) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol tetrakisphosphate 3-kinase activity. An important paralog of this gene is IP6K2.

UniProtKB/Swiss-Prot for IPMK Gene

  • Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPMK Gene

Genomics for IPMK Gene

Genomic Location for IPMK Gene

Start:
58,191,517 bp from pter
End:
58,267,934 bp from pter
Size:
76,418 bases
Orientation:
Minus strand

Genomic View for IPMK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IPMK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPMK Gene

Regulatory Elements for IPMK Gene

Proteins for IPMK Gene

  • Protein details for IPMK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU5-IPMK_HUMAN
    Recommended name:
    Inositol polyphosphate multikinase
    Protein Accession:
    Q8NFU5
    Secondary Accessions:

    Protein attributes for IPMK Gene

    Size:
    416 amino acids
    Molecular mass:
    47222 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IPMK Gene

Proteomics data for IPMK Gene at MOPED

Post-translational modifications for IPMK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IPMK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IPMK Gene

Domains for IPMK Gene

Protein Domains for IPMK Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

IPMK_HUMAN
Family:
  • Belongs to the inositol phosphokinase (IPK) family.:
    • Q8NFU5
genes like me logo Genes that share domains with IPMK: view

No data available for Gene Families for IPMK Gene

Function for IPMK Gene

Molecular function for IPMK Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
UniProtKB/Swiss-Prot Function: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).

Enzyme Numbers (IUBMB) for IPMK Gene

Gene Ontology (GO) - Molecular Function for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity IEA --
GO:0000824 inositol tetrakisphosphate 3-kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA --
genes like me logo Genes that share ontologies with IPMK: view
genes like me logo Genes that share phenotypes with IPMK: view

Animal Models for IPMK Gene

MGI Knock Outs for IPMK:

miRNA for IPMK Gene

miRTarBase miRNAs that target IPMK

No data available for Transcription Factor Targeting and HOMER Transcription for IPMK Gene

Localization for IPMK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPMK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPMK Gene COMPARTMENTS Subcellular localization image for IPMK gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with IPMK: view

Pathways for IPMK Gene

genes like me logo Genes that share pathways with IPMK: view

Interacting Proteins for IPMK Gene

Gene Ontology (GO) - Biological Process for IPMK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001841 neural tube formation IEA --
GO:0016310 phosphorylation IEA --
GO:0032958 inositol phosphate biosynthetic process IEA --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with IPMK: view

Compounds for IPMK Gene

(5) HMDB Compounds for IPMK Gene

Compound Synonyms Cas Number PubMed IDs
1D-Myo-inositol 1,4,5,6-tetrakisphosphate
  • D-myo-Inositol 1,4,5,6-tetrakisphosphate
121010-58-0
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Inositol 1,3,4,5,6-pentakisphosphate
  • 1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
20298-95-7
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate
88269-39-0

(4) Novoseek inferred chemical compound relationships for IPMK Gene

Compound -log(P) Hits PubMed IDs
inositol 1,3,4,6-tetrakisphosphate 95.7 3
inositol 1,3,4,5-tetrakisphosphate 81.3 1
inositol 1,4,5 trisphosphate 60.1 3
inositol 52.8 2
genes like me logo Genes that share compounds with IPMK: view

Transcripts for IPMK Gene

mRNA/cDNA for IPMK Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IPMK Gene

Inositol polyphosphate multikinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPMK Gene

No ASD Table

Relevant External Links for IPMK Gene

GeneLoc Exon Structure for
IPMK
ECgene alternative splicing isoforms for
IPMK

Expression for IPMK Gene

mRNA expression in normal human tissues for IPMK Gene

mRNA differential expression in normal tissues according to GTEx for IPMK Gene

This gene is overexpressed in Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPMK Gene

SOURCE GeneReport for Unigene cluster for IPMK Gene Hs.30280

mRNA Expression by UniProt/SwissProt for IPMK Gene

Q8NFU5-IPMK_HUMAN
Tissue specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
genes like me logo Genes that share expressions with IPMK: view

Orthologs for IPMK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IPMK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPMK 36
  • 99.6 (n)
  • 99.52 (a)
IPMK 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IPMK 36
  • 92.47 (n)
  • 91.59 (a)
IPMK 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipmk 36
  • 80.98 (n)
  • 84.6 (a)
Ipmk 16
Ipmk 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IPMK 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPMK 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipmk 36
  • 80.98 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves IPMK 36
  • 75.52 (n)
  • 80.47 (a)
IPMK 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPMK 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1741 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ipmk 36
  • 68.14 (n)
  • 67.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ipmka 37
  • 58 (a)
OneToMany
ipmkb 36
  • 61.11 (n)
  • 63.22 (a)
ipmkb 37
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012099 36
  • 44.44 (n)
  • 30.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ipk2 36
  • 48.12 (n)
  • 40.73 (a)
Ipk2 37
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_ZK795.1 36
  • 47.5 (n)
  • 33.05 (a)
ZK795.1 37
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 37
  • 7 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons IPK2a 36
  • 44.07 (n)
  • 31.25 (a)
rice
(Oryza sativa)
Liliopsida Os02g0523800 36
  • 38.12 (n)
  • 27.78 (a)
Species with no ortholog for IPMK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IPMK Gene

ENSEMBL:
Gene Tree for IPMK (if available)
TreeFam:
Gene Tree for IPMK (if available)

Paralogs for IPMK Gene

Paralogs for IPMK Gene

Pseudogenes.org Pseudogenes for IPMK Gene

genes like me logo Genes that share paralogs with IPMK: view

Variants for IPMK Gene

Sequence variations from dbSNP and Humsavar for IPMK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs767008 -- 58,238,848(-) AAAAA(A/C)AAAAA intron-variant
rs767009 -- 58,238,841(-) AAAAA(A/C)AAACT intron-variant
rs946555 -- 58,266,739(-) TAAGG(C/T)TGTAT intron-variant
rs1115435 -- 58,248,850(+) ATCCA(C/T)GTTGC intron-variant
rs1199094 -- 58,192,869(-) CTCAG(A/T)TACCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IPMK Gene

Variant ID Type Subtype PubMed ID
nsv895559 CNV Loss 21882294
nsv895560 CNV Loss 21882294

Relevant External Links for IPMK Gene

HapMap Linkage Disequilibrium report
IPMK

Disorders for IPMK Gene

Relevant External Links for IPMK

Genetic Association Database (GAD)
IPMK
genes like me logo Genes that share disorders with IPMK: view

No data available for UniProtKB/Swiss-Prot for IPMK Gene

Publications for IPMK Gene

  1. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (PMID: 12027805) Nalaskowski M.M. … Mayr G.W. (Biochem. J. 2002) 2 3 4 23
  2. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. (PMID: 12223481) Chang S.-C. … Majerus P.W. (J. Biol. Chem. 2002) 2 3 4 23
  3. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. (PMID: 15659385) Mayr G.W. … Hillemeier K. (J. Biol. Chem. 2005) 3 23
  4. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. (PMID: 16247451) Morgan-Lappe S. … Leverson J.D. (Oncogene 2006) 3 23
  5. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. (PMID: 16293229) Chang S.C. … Majerus P.W. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for IPMK Gene

  • Addgene plasmids for IPMK

Sources for IPMK Gene

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