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IPMK Gene

protein-coding   GIFtS: 53
GCID: GC10M059951

Inositol Polyphosphate Multikinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol Polyphosphate Multikinase1 2
Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase2 3
EC 2.7.1.1513
IMPK3

External Ids:    HGNC: 207391   Entrez Gene: 2534302   Ensembl: ENSG000001511517   OMIM: 6098515   UniProtKB: Q8NFU53   

Export aliases for IPMK gene to outside databases

Previous GC identifers: GC10M059625 GC10M053944


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IPMK Gene:
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and
6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the
biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a
role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short
arm of chromosome 19. (provided by RefSeq, Dec 2010)

GeneCards Summary for IPMK Gene:
IPMK (inositol polyphosphate multikinase) is a protein-coding gene. Diseases associated with IPMK include inflammatory bowel disease, and obesity. GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol tetrakisphosphate 3-kinase activity. An important paralog of this gene is IP6K3.

UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
Function: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol
1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the IPMK gene promoter:
         Pbx1a   p53   AML1a   CUTL1   Tal-1beta   Cdc5   E47   ZIC2/Zic2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPMK promoter sequence
   Search Chromatin IP Primers for IPMK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IPMK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q21.1

IPMK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPMK gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M059951:  view genomic region     (about GC identifiers)

Start:
59,951,278 bp from pter      End:
60,027,694 bp from pter
Size:
76,417 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5 (See protein sequence)
Recommended Name: Inositol polyphosphate multikinase  
Size: 416 amino acids; 47222 Da

Explore the universe of human proteins at neXtProt for IPMK: NX_Q8NFU5

Explore proteomics data for IPMK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IPMK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689416.1  
    ENSEMBL proteins: 
     ENSP00000363046  
    Reactome Protein details: Q8NFU5

    IPMK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals IPMK Proteins
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    IPMK Antibody Products:

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    Abcam antibodies for IPMK
    Cloud-Clone Corp. Antibodies for IPMK
    ThermoFisher Antibody for IPMK
    LSBio Antibodies in human, mouse, rat for IPMK

    IPMK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IPMK
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    Cloud-Clone Corp. ELISAs for IPMK
    Cloud-Clone Corp. CLIAs for IPMK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005522 IPK

    Graphical View of Domain Structure for InterPro Entry Q8NFU5

    ProtoNet protein and cluster: Q8NFU5

    UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
    Similarity: Belongs to the inositol phosphokinase (IPK) family


    IPMK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPMK_HUMAN, Q8NFU5
    Function: Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol
    1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4)
    Catalytic activity: 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol
    1,3,4,5,6-pentakisphosphate

         Enzyme Number (IUBMB): EC 2.7.1.1511

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000823inositol-1,4,5-trisphosphate 6-kinase activity IEA--
    GO:0000824inositol tetrakisphosphate 3-kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity IEA--
         
    IPMK for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for IPMK:
     Decreased CYP1A1 activity afte  Decreased Wnt reporter activit  Decreased cilium length after   Decreased focal adhesion (FA)  

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ipmk):
     embryogenesis  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 

    IPMK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ipmktm1Yrk for IPMK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IPMK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IPMK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IPMK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IPMK

    miRNA
    Products:
        
    miRTarBase miRNAs that target IPMK:
    hsa-mir-335-5p (MIRT017660), hsa-mir-339-5p (MIRT042775)

    Block miRNA regulation of human, mouse, rat IPMK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPMK (see all 125):
    hsa-miR-548j hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-128 hsa-miR-485-3p hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidIPMK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IPMK
    Predesigned siRNA for gene silencing in human, mouse, rat IPMK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IPMK

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IPMK (NM_152230)
    Sino Biological Human cDNA Clone for IPMK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPMK

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IPMK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPMK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IPMK_HUMAN, Q8NFU5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    IPMK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IPMK About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis0.00
    superpathway of inositol phosphate compounds0.60
    1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)0.00
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism0.00
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)0.00
    2Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis0.00
    Synthesis of IPs in the nucleus0.00
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis0.00
    inositol pyrophosphates biosynthesis0.00
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for IPMK (see all 8)
        1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    inositol pyrophosphates biosynthesis
    D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
    D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis


    1 Reactome Pathway for IPMK
        Synthesis of IPs in the nucleus


    1 Kegg Pathway  (Kegg details for IPMK):
        Inositol phosphate metabolism


    IPMK for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including IPMK: 
              Nephrotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IPMK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IPMK (Q8NFU53 ENSP000003630464) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUT8Q9BYC53I2D: score=4 
    NOP58Q9Y2X33I2D: score=4 
    ST13P505023I2D: score=1 
    INPP5AENSP000003575834STRING: ENSP00000357583
    INPP5BENSP000003621154STRING: ENSP00000362115
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001841neural tube formation IEA--
    GO:0032958inositol phosphate biosynthetic process IEA--
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    IPMK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IPMK

    5 HMDB Compounds for IPMK    About this table
    CompoundSynonyms CAS #PubMed Ids
    1D-Myo-inositol 1,4,5,6-tetrakisphosphateD-myo-Inositol 1,4,5,6-tetrakisphosphate (see all 3)121010-58-0--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Inositol 1,3,4,5,6-pentakisphosphate1D-myo-Inositol 1,3,4,5,6-pentakisphosphate (see all 5)20298-95-7--
    Inositol 1,4,5-trisphosphate1D-myo-Inositol 1,4,5-trisphosphate (see all 4)88269-39-0--

    4 Novoseek inferred chemical compound relationships for IPMK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,6-tetrakisphosphate 95.7 3 12223481 (2), 16293229 (1)
    inositol 1,3,4,5-tetrakisphosphate 81.3 1 16293229 (1)
    inositol 1,4,5 trisphosphate 60.1 5 15659385 (2), 16293229 (1)
    inositol 52.8 4 15659385 (1), 12027805 (1)



    IPMK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IPMK gene: 
    NM_152230.4  

    Unigene Cluster for IPMK:

    Inositol polyphosphate multikinase
    Hs.30280  [show with all ESTs]
    Unigene Representative Sequence: NM_152230
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373935(uc001jkb.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat IPMK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IPMK (see all 125):
    hsa-miR-548j hsa-miR-3938 hsa-miR-376b hsa-miR-106a hsa-miR-128 hsa-miR-485-3p hsa-miR-3074-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidIPMK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IPMK
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IPMK (NM_152230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPMK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPMK
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IPMK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IPMK
      QuantiTect SYBR Green Assays in human, mouse, rat IPMK
      QuantiFast Probe-based Assays in human, mouse, rat IPMK

    Additional mRNA sequence: 

    AF432853.1 AK096839.1 BC016612.1 BC065709.1 

    3 DOTS entries:

    DT.40207909  DT.408134  DT.102826332 

    Selected AceView cDNA sequences (see all 30):

    AF432853 BU167197 BC065709 BK000580 BX502197 BV189718 AK096839 NM_152230 
    AI478349 BQ439197 BG258567 BC016612 BU928323 BX497598 BE887612 BX101471 
    CD637634 AA974259 BE242273 AI336916 CD637637 AI650448 AI862081 CD637626 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IPMK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IPMK Expression
    About this image

    IPMK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IPMK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30280

    UniProtKB/Swiss-Prot: IPMK_HUMAN, Q8NFU5
    Tissue specificity: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral
    blood leukocytes, kidney, spleen and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including IPMK: 
              Nephrotoxicity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IPMK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IPMK
    QuantiTect SYBR Green Assays in human, mouse, rat IPMK
    QuantiFast Probe-based Assays in human, mouse, rat IPMK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPMK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IPMK gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ipmk1 , 5 inositol polyphosphate multikinase1, 5 80.98(n)1
    84.6(a)1
      10 (36.89 cM)5
    697181  NM_027184.11  NP_081460.11 
     713477635 
    chicken
    (Gallus gallus)
    Aves IPMK1 inositol polyphosphate multikinase 75.52(n)
    80.47(a)
      101751177  XM_004942058.1  XP_004942115.1 
    lizard
    (Anolis carolinensis)
    Reptilia IPMK6
    inositol polyphosphate multikinase
    76(a)
    1 ↔ 1
    GL343378.1(140027-164581)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.17412 Xenopus laevis transcribed sequences 76.84(n)    BG551900.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ipmkb1 inositol polyphosphate multikinase b 61.11(n)
    63.22(a)
      790916  NM_001080064.1  NP_001073533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ipk21 Ipk2 48.12(n)
    40.73(a)
      33236  NM_134691.2  NP_608535.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_ZK795.11 CELE_ZK795.1 47.5(n)
    33.05(a)
      191426  NM_070001.3  NP_502402.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KCS16
    Inositol hexakisphosphate (IP6) and inositol hepta...
    7(a)
    1 → many
    IV(479115-482267) YDR017C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IPK2a1 IPK2a 44.07(n)
    31.25(a)
      830628  NM_180456.1  NP_850787.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05238001 Os02g0523800 38.12(n)
    27.78(a)
      4329509  NM_001053521.1  NP_001046986.1 


    ENSEMBL Gene Tree for IPMK (if available)
    TreeFam Gene Tree for IPMK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IPMK gene
    IP6K32  IP6K12  IP6K22  

    IPMK for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IPMK
    PGOHUM00000248329 PGOHUM00000234187


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IPMK (see all 1583)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1995619591,2
    --59950794(+) ACATG-/TTTTTT 1 -- ds50010--------
    rs1863201451,2
    --59950883(+) ACTAAC/TTTCTG 1 -- ds50010--------
    rs579032821,2
    C--59950932(+) AAAAA-/A/AAAA
    A
    /AAAAAA
    CCTTA
    2 -- ds5001 cds11NA 2
    rs1476455991,2
    --59951028(+) AAAGAC/TTTGTT 1 -- ds50010--------
    rs1422295071,2
    --59951258(+) AGCATA/GTTACA 1 -- ds50010--------
    rs798745041,2
    C,F--59951311(+) TCAAAT/CATACA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1913632821,2
    --59951313(+) AAATAC/TACAGT 1 -- ut310--------
    rs1444124161,2
    --59951403(+) ACATTA/GACAAT 1 -- ut310--------
    rs579266831,2
    C--59951461(+) AAAAA-/ACCCTA 1 -- ut310--------
    rs1827873011,2
    --59951535(+) AAGTAC/GAATAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IPMK (59951278 - 60027694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IPMK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895560CNV Loss21882294
    nsv895559CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IPMK
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609851    OMIM disorders: --

    3 diseases for IPMK:    
    About MalaCards
    inflammatory bowel disease    obesity    malaria


    IPMK for disorders           About GeneDecksing

    Genetic Association Database (GAD): IPMK

    Export disorders for IPMK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IPMK gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with IPMK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. (PubMed id 12027805)1, 2, 3, 9 Nalaskowski M.M.... Mayr G.W. (Biochem. J. 2002)
    2. The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase. (PubMed id 12223481)1, 2, 3, 9 Chang S.-C.... Majerus P.W. (J. Biol. Chem. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. (PubMed id 15659385)1, 9 Mayr G.W....Hillemeier K. (J. Biol. Chem. 2005)
    5. Inositol polyphosphate multikinase: metabolic architect of nuclear inositides. (PubMed id 17981594)1, 9 Resnick A.C. and Saiardi A. (Front. Biosci. 2008)
    6. Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate. (PubMed id 16293229)1, 9 Chang S.C. and Majerus P.W. (Biochem. Biophys. Res. Commun. 2006)
    7. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors. (PubMed id 16247451)1, 9 Morgan-Lappe S....Leverson J.D. (Oncogene 2006)
    8. Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity. (PubMed id 24074953)1 Wickramasinghe V.O....Venkitaraman A.R. (Mol. Cell 2013)
    9. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    10. Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. (PubMed id 23550211)1 Xu R....Snyder S.H. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253430 HGNC: 20739 AceView: IPMK Ensembl:ENSG00000151151 euGenes: HUgn253430
    ECgene: IPMK Kegg: 253430 H-InvDB: IPMK

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IPMK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IPMK gene:
    Search GeneIP for patents involving IPMK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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