Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IPCEF1 Gene

protein-coding   GIFtS: 51
GCID: GC06M154517

interaction protein for cytohesin exchange factors 1

 Explore 4 diseases affiliated with
IPCEF1 via our new
 Human Malady Compendium 
Biological research products
for IPCEF1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interaction Protein For Cytohesin Exchange Factors 11 2     RP3-402L9.22
PIP3-E1 2     Interaction Protein For Cytohesin Exchange Factors 1 Interaction Protein For
Cytohesin Exchange Factors 12
KIAA04031 3     Interactor Protein For Cytohesin Exchange Factors 12
Phosphoinositide-Binding Protein PIP3-E2 3     Phosphoinositide Binding Protein PIP3-E2

External Ids:    HGNC: 212041   Entrez Gene: 260342   Ensembl: ENSG000000747067   UniProtKB: Q8WWN93   

Export aliases for IPCEF1 gene to outside databases

Previous GC identifer: GC06M152038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ICEF1_HUMAN, Q8WWN9
Function: Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IPCEF1 gene promoter:
         STAT5B   LHX3b/Lhx3b   FOXC1   LHX3a/Lhx3a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIPCEF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IPCEF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPCEF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2   Ensembl cytogenetic band:  6q25.2   HGNC cytogenetic band: 6q25.2

IPCEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IPCEF1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M154517:  view genomic region     (about GC identifiers)

Start:
154,475,618 bp from pter      End:
154,677,926 bp from pter
Size:
202,309 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ICEF1_HUMAN, Q8WWN9 (See protein sequence)
Recommended Name: Interactor protein for cytohesin exchange factors 1  
Size: 437 amino acids; 48993 Da
Subunit: Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated with PSCD2 to the
plasma membrane upon epidermal growth factor (EGF) stimulation (By similarity)
Caution: It is uncertain whether Met-1 or Met-29 is the initiator
Secondary accessions: A8K1K2 B7ZL78 B7ZL80 O43153 Q5HYL8
Alternative splicing: 2 isoforms:  Q8WWN9-1   Q8WWN9-2   

Explore the universe of human proteins at neXtProt for IPCEF1: NX_Q8WWN9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWN9

  • IPCEF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124171.1  NP_001124172.1  NP_056368.1  

    ENSEMBL proteins: 
     ENSP00000265198   ENSP00000394751   ENSP00000356189   ENSP00000430287   ENSP00000431092  
     ENSP00000428767   ENSP00000429972   ENSP00000431004  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IPCEF1
    OriGene Protein Over-expression Lysate: IPCEF1
    OriGene Custom Protein Services for IPCEF1 
    GenScript Custom Purified and Recombinant Proteins Services for IPCEF1
    Novus Biologicals IPCEF1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IPCEF1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--


    IPCEF1 for ontologies           About GeneDecksing



    IPCEF1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: IPCEF1
    OriGene Custom Antibody Services for IPCEF1 
    GenScript Custom Superior Antibodies Services for IPCEF1
    Novus Biologicals IPCEF1 Antibodies
    Search for Antibodies for IPCEF1 at Abcam  
    Uscn Antibodies for IPCEF1
    ThermoFisher Antibodies for IPCEF1

    Assay Products for IPCEF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IPCEF1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IPCEF1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IPCEF1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WWN9

    ProtoNet protein and cluster: Q8WWN9

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: ICEF1_HUMAN, Q8WWN9
    Similarity: Contains 1 PH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ICEF1_HUMAN, Q8WWN9
    Function: Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner
    (By similarity)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 3): IPCEF1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPCEF1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate IPCEF1 (see all 39):
    hsa-miR-21* hsa-miR-345 hsa-miR-3678-3p hsa-miR-4328 hsa-miR-4272 hsa-miR-3074-3p hsa-miR-628-3p hsa-miR-3923
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPCEF1 (see all 4)
    OriGene shRNA RFP: IPCEF1
    OriGene siRNA: IPCEF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPCEF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IPCEF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPCEF1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPCEF1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IPCEF1 (NM_001130699)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPCEF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPCEF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IPCEF1
    Search LifeMap BioReagents cell lines for IPCEF1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPCEF1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity ISS11320098
    GO:0005344oxygen transporter activity NAS11919282
    GO:0005543phospholipid binding IEA--


    IPCEF1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Arf6 signaling events
    Arf6 signaling events1.00


    1 BioSystems Pathway for IPCEF1 
        Arf6 signaling events


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IPCEF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for IPCEF1 (Q8WWN93 ENSP000003561894) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYTH2Q994183, ENSP000004082364I2D: score=3 STRING: ENSP00000408236
    CYTH1Q154383, ENSP000003543984I2D: score=1 STRING: ENSP00000354398
    CYTH3O437393, ENSP000002970444I2D: score=1 STRING: ENSP00000297044
    CYTH4Q9UIA03, ENSP000002489014I2D: score=1 STRING: ENSP00000248901
    ARF6ENSP000002983164STRING: ENSP00000298316
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress ISS11320098
    GO:0015671oxygen transport NAS11919282


    IPCEF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IPCEF1
    Search CenterWatch for drugs/clinical trials and news about IPCEF1 / ICEF1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IPCEF1 gene (3 alternative transcripts): 
    NM_001130699.1  NM_001130700.1  NM_015553.2  

    Unigene Cluster for IPCEF1:

    Interaction protein for cytohesin exchange factors 1
    Hs.146100  [show with all ESTs]
    Unigene Representative Sequence: NM_001130699
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470622 ENST00000265198(uc003qpv.3 uc003qpw.3 uc003qpx.3 uc010kjh.3 uc021zhc.1)
    ENST00000422970 ENST00000522590 ENST00000367220(uc021zhd.1 uc021zhe.1)
    ENST00000519344 ENST00000519091 ENST00000484827 ENST00000517438 ENST00000519405
    ENST00000519190 ENST00000518162 ENST00000520261

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): IPCEF1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IPCEF1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate IPCEF1 (see all 39):
    hsa-miR-21* hsa-miR-345 hsa-miR-3678-3p hsa-miR-4328 hsa-miR-4272 hsa-miR-3074-3p hsa-miR-628-3p hsa-miR-3923
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPCEF1 (see all 4)
    OriGene shRNA RFP: IPCEF1
    OriGene siRNA: IPCEF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPCEF1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPCEF1 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPCEF1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IPCEF1 (NM_001130699)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IPCEF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPCEF1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPCEF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPCEF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPCEF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPCEF1

    Additional cDNA sequence: 

    AB007863.1 AJ310566.1 AK093997.1 AK289917.1 BC105015.1 BC105043.1 BC143623.1 BC143629.1 
    BX647254.1 JF308523.1 JF308524.1 

    5 DOTS entries:

    DT.95260368  DT.414270  DT.121333189  DT.99927455  DT.91961294 

    24/51 AceView cDNA sequences (see all 51):

    AI619698 BQ002283 AL596936 F11818 AI570712 AL707879 BF436873 AL119039 
    NM_015553 BF899423 Z45199 AB007863 AX748403 BX106196 AI571473 AK093997 
    CD522075 AJ310566 D80726 N53325 D60144 D80573 Z40926 AW268440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IPCEF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGCTGGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    IPCEF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IPCEF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IPCEF1

    SOURCE GeneReport for Unigene cluster: Hs.146100
        SABiosciences Custom PCR Arrays for IPCEF1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPCEF1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IPCEF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPCEF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPCEF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPCEF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IPCEF1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IPCEF11 interaction protein for cytohesin exchange factors more 66.99(n)
    62.9(a)
      421645  XM_419684.3  XP_419684.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    21(a)
    1 → many
    1(215103884-215232595)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1540181 zgc:154018 56.44(n)
    50.69(a)
      767791  NM_001076758.1  NP_001070226.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cnk6
    connector enhancer of ksr
    5(a)
    possible ortholog
    2R(13301476-13307104)
    worm
    (Caenorhabditis elegans)
    Secernentea cnk-16
    Connector/eNhancer of KSR family member (cnk-1)
    4(a)
    possible ortholog
    III(10271166-10278488)


    ENSEMBL Gene Tree for IPCEF1 (if available)
    TreeFam Gene Tree for IPCEF1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IPCEF1 gene
    CNKSR12  CNKSR32  CNKSR22  
    2 SIMAP similar genes for IPCEF1 using alignment to 6 protein entries:     ICEF1_HUMAN (see all proteins):
    CNKSR2    MYO10

    IPCEF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2122 NCBI SNPs in IPCEF1 are shown (see all 2122    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001539661,2
    C,--154568610(+) CTGACA/GCAAGG 6 R C mis10--------
    rs1906519571,2
    C,--154568656(+) GAAATA/TTCTGA 3 -- int10--------
    rs2021096131,2
    --154568672(+) TTGTAA/GCATTT 3 -- int10--------
    rs801423971,2
    --154568720(+) GAGCAA/GGATGG 3 -- int10--------
    rs1149551291,2
    F,--154568767(+) GGAGCT/CACTAG 3 -- int11Minor allele frequency- C:0.06WA 118
    rs1134478781,2
    C,--154568883(+) CAAGCC/TGCTCT 3 -- int11Minor allele frequency- T:0.50NA 2
    rs1826715571,2
    --154568909(+) TATGAC/TAGCAC 3 -- int10--------
    rs1505994681,2
    --154568988(+) TATATC/TTGCTT 3 -- int10--------
    rs772033431,2
    F,--154568991(+) ATCTGC/GTTCTT 3 -- int11Minor allele frequency- G:0.03WA 118
    rs1858628421,2
    --154569038(+) CCTGGA/GAGATA 3 -- int10--------

    HapMap Linkage Disequilibrium report for IPCEF1 (154475618 - 154677926 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 20 variations for IPCEF1
         13 CNVs: 94123 81662 99764 7530 81665 59308 94125 64690 81664 94118 94124 81666 81663
         6 Indels: 94121 81660 94120 81661 94119 94122
         1 Inversion: 59837

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPCEF1
    DNA2.0 Custom Variant and Variant Library Synthesis for IPCEF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IPCEF1 for disorders           About GeneDecksing

    4 diseases for IPCEF1:    About MalaCards
    oral squamous cell carcinoma    squamous cell carcinoma    carcinoma    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: IPCEF1 (5 documents)

    Export disorders for IPCEF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IPCEF1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with IPCEF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PubMed id 11804589)1, 2, 3 Krugmann S....Hawkins P.T. (2002)
    2. Peripheral nerve injury up-regulates expression of in teractor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal ro ot ganglion. (PubMed id 19756519)1, 3 Guan X....Tao Y.X. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    5. CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. (PubMed id 22085542)1 Attar M.A.... Santy L.C. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. (PubMed id 20016009)1 White D.T....Santy L.C. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26034 HGNC: 21204 AceView: PIP3-E Ensembl:ENSG00000074706 euGenes: HUgn26034
    ECgene: IPCEF1 H-InvDB: IPCEF1

    (According to HUGE)
    About This Section
    HUGE: KIAA0403

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IPCEF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IPCEF1 gene:
    Search GeneIP for patents involving IPCEF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for IPCEF1   OriGene shRNA RFP for IPCEF1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IPCEF1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IPCEF1  
     OriGene Protein Over-expression Lysate for IPCEF1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for IPCEF1   OriGene 3'-UTR Clone for IPCEF1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IPCEF1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IPCEF1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for IPCEF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IPCEF1   OriGene Custom Protein Services for IPCEF1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IPCEF1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IPCEF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IPCEF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IPCEF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IPCEF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IPCEF1
     GenScript Custom Purified and Recombinant Proteins Services for IPCEF1 GenScript cDNA clones with any tag delivered in your preferred vector for IPCEF1
     GenScript Custom Assay Services for IPCEF1 GenScript Custom Superior Antibodies Services for IPCEF1
     GenScript Custom overexpressing Cell Line Services for IPCEF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IPCEF1 promoter
     Search Chromatin IP Primers for IPCEF1
     RT2 qPCR Primer Assay in human, mouse, rat IPCEF1
     Search GNC Networks for IPCEF1
     SABiosciences Custom PCR Arrays for IPCEF1
     Search Tocris compounds for IPCEF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IPCEF1 antibodies
     IPCEF1 lysates
     Search for Antibodies for IPCEF1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for IPCEF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     IPCEF1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for IPCEF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IPCEF1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IPCEF1
     SwitchGear Promoter luciferase reporter plasmids for IPCEF1
     ThermoFisher Antibodies for IPCEF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IPCEF1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IPCEF1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4