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Aliases for IPCEF1 Gene

Aliases for IPCEF1 Gene

  • Interaction Protein For Cytohesin Exchange Factors 1 2 3 5
  • Phosphoinositide Binding Protein PIP3-E 2 3
  • Phosphoinositide-Binding Protein PIP3-E 3 4
  • Interaction Protein For Cytohesin Exchange Factors 1 Interaction Protein For Cytohesin Exchange Factors 1 3
  • KIAA0403 4
  • PIP3-E 3

External Ids for IPCEF1 Gene

Previous GeneCards Identifiers for IPCEF1 Gene

  • GC06M154517
  • GC06M152038

Summaries for IPCEF1 Gene

GeneCards Summary for IPCEF1 Gene

IPCEF1 (Interaction Protein For Cytohesin Exchange Factors 1) is a Protein Coding gene. Among its related pathways are Arf6 signaling events. GO annotations related to this gene include peroxidase activity and oxygen transporter activity. An important paralog of this gene is CNKSR1.

UniProtKB/Swiss-Prot for IPCEF1 Gene

  • Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPCEF1 Gene

Genomics for IPCEF1 Gene

Regulatory Elements for IPCEF1 Gene

Enhancers for IPCEF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IPCEF1 on UCSC Golden Path with GeneCards custom track

Promoters for IPCEF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IPCEF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IPCEF1 Gene

Chromosome:
6
Start:
154,154,483 bp from pter
End:
154,356,802 bp from pter
Size:
202,320 bases
Orientation:
Minus strand

Genomic View for IPCEF1 Gene

Genes around IPCEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IPCEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IPCEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPCEF1 Gene

Proteins for IPCEF1 Gene

  • Protein details for IPCEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWN9-ICEF1_HUMAN
    Recommended name:
    Interactor protein for cytohesin exchange factors 1
    Protein Accession:
    Q8WWN9
    Secondary Accessions:
    • A8K1K2
    • B7ZL78
    • B7ZL80
    • O43153
    • Q5HYL8

    Protein attributes for IPCEF1 Gene

    Size:
    437 amino acids
    Molecular mass:
    48993 Da
    Quaternary structure:
    • Interacts with guanine-nucleotide exchange factors PSCD1, PSCD2, PSCD3 and PSCD4.

    Alternative splice isoforms for IPCEF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IPCEF1 Gene

Proteomics data for IPCEF1 Gene at MOPED

Post-translational modifications for IPCEF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for PIP3E

No data available for DME Specific Peptides for IPCEF1 Gene

Domains & Families for IPCEF1 Gene

Gene Families for IPCEF1 Gene

Protein Domains for IPCEF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IPCEF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWN9

UniProtKB/Swiss-Prot:

ICEF1_HUMAN :
  • Contains 1 PH domain.
Domain:
  • Contains 1 PH domain.
genes like me logo Genes that share domains with IPCEF1: view

Function for IPCEF1 Gene

Molecular function for IPCEF1 Gene

UniProtKB/Swiss-Prot Function:
Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner.

Gene Ontology (GO) - Molecular Function for IPCEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity ISS 11320098
genes like me logo Genes that share ontologies with IPCEF1: view
genes like me logo Genes that share phenotypes with IPCEF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IPCEF1 Gene

Localization for IPCEF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPCEF1 Gene

Cytoplasm. Cell membrane. Note=Translocated with PSCD2 to the plasma membrane upon epidermal growth factor (EGF) stimulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPCEF1 Gene COMPARTMENTS Subcellular localization image for IPCEF1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
mitochondrion 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for IPCEF1 Gene

Pathways & Interactions for IPCEF1 Gene

SuperPathways for IPCEF1 Gene

Superpath Contained pathways
1 Arf6 signaling events
genes like me logo Genes that share pathways with IPCEF1: view

Pathways by source for IPCEF1 Gene

1 BioSystems pathway for IPCEF1 Gene

Gene Ontology (GO) - Biological Process for IPCEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015671 oxygen transport NAS 11919282
genes like me logo Genes that share ontologies with IPCEF1: view

No data available for SIGNOR curated interactions for IPCEF1 Gene

Drugs & Compounds for IPCEF1 Gene

No Compound Related Data Available

Transcripts for IPCEF1 Gene

Unigene Clusters for IPCEF1 Gene

Interaction protein for cytohesin exchange factors 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPCEF1 Gene

No ASD Table

Relevant External Links for IPCEF1 Gene

GeneLoc Exon Structure for
IPCEF1
ECgene alternative splicing isoforms for
IPCEF1

Expression for IPCEF1 Gene

mRNA expression in normal human tissues for IPCEF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IPCEF1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.5), Brain - Cortex (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.7), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for IPCEF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), CD8 Tcells (20.0), and Frontal cortex (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IPCEF1 Gene



SOURCE GeneReport for Unigene cluster for IPCEF1 Gene Hs.146100

genes like me logo Genes that share expression patterns with IPCEF1: view

Protein tissue co-expression partners for IPCEF1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IPCEF1 Gene

Orthologs for IPCEF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPCEF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IPCEF1 35
  • 84.84 (n)
  • 81.44 (a)
-- 36
  • 80 (a)
ManyToMany
-- 36
  • 2 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ipcef1 35
  • 81.89 (n)
  • 80.99 (a)
Ipcef1 16
Cnksr3 36
  • 2 (a)
ManyToMany
Ipcef1 36
  • 80 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia IPCEF1 35
  • 99.31 (n)
  • 99.08 (a)
-- 36
  • 99 (a)
ManyToMany
CNKSR3 36
  • 2 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ipcef1 35
  • 82.63 (n)
  • 80 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 2 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 2 (a)
OneToMany
chicken
(Gallus gallus)
Aves IPCEF1 35
  • 69.07 (n)
  • 65.55 (a)
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 1 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:154018 36
  • 44 (a)
ManyToMany
zgc:172112 36
  • 2 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta cnk 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnk-1 36
  • 5 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOI1 38
Species with no ortholog for IPCEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IPCEF1 Gene

ENSEMBL:
Gene Tree for IPCEF1 (if available)
TreeFam:
Gene Tree for IPCEF1 (if available)

Paralogs for IPCEF1 Gene

Paralogs for IPCEF1 Gene

(2) SIMAP similar genes for IPCEF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IPCEF1: view

Variants for IPCEF1 Gene

Sequence variations from dbSNP and Humsavar for IPCEF1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_042410 -
rs1293925 -- 154,313,844(+) ACTCA(A/G)GCAAT intron-variant
rs1293926 -- 154,314,498(+) ACCTA(A/G)GAAAC intron-variant
rs1293927 -- 154,316,259(+) ttaga(C/T)gtatg intron-variant
rs1293928 -- 154,319,612(+) ACCAA(A/G)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPCEF1 Gene

Variant ID Type Subtype PubMed ID
nsv830847 CNV Gain 17160897
nsv5550 CNV Insertion 18451855
esv32616 CNV Loss 17666407
esv2677305 CNV Deletion 23128226
nsv523401 CNV Gain 19592680
nsv886785 CNV Gain 21882294
nsv819588 CNV Gain 19587683
nsv823877 CNV Loss 20364138
esv21915 CNV Gain+Loss 19812545
nsv821323 CNV Deletion 20802225
esv2732938 CNV Deletion 23290073
esv1002780 CNV Gain 20482838
nsv823878 CNV Gain 20364138
esv2665555 CNV Deletion 23128226
esv2732939 CNV Deletion 23290073
nsv886786 CNV Gain 21882294
esv6100 OTHER Inversion 19470904
esv2510969 CNV Insertion 19546169

Variation tolerance for IPCEF1 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IPCEF1 Gene

Disorders for IPCEF1 Gene

Relevant External Links for IPCEF1

Genetic Association Database (GAD)
IPCEF1
Human Genome Epidemiology (HuGE) Navigator
IPCEF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IPCEF1

No disorders were found for IPCEF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IPCEF1 Gene

Publications for IPCEF1 Gene

  1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PMID: 11804589) Krugmann S. … Hawkins P.T. (Mol. Cell 2002) 2 3 4 67
  2. Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion. (PMID: 19756519) Guan X. … Tao Y.X. (Naunyn Schmiedebergs Arch. Pharmacol. 2009) 2 3
  3. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3
  4. CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. (PMID: 22085542) Attar M.A. … Santy L.C. (Exp. Cell Res. 2011) 3
  5. GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180. (PMID: 20016009) White D.T. … Santy L.C. (Mol. Biol. Cell 2010) 3

Products for IPCEF1 Gene

Sources for IPCEF1 Gene

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