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Aliases for IP6K3 Gene

Aliases for IP6K3 Gene

  • Inositol Hexakisphosphate Kinase 3 2 3
  • Inositol Hexaphosphate Kinase 3 2 3 4
  • IHPK3 3 4 6
  • InsP6 Kinase 3 3 4
  • EC 4 63
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • INSP6K3, 6
  • INSP6K3 3

External Ids for IP6K3 Gene

Previous HGNC Symbols for IP6K3 Gene

  • IHPK3

Previous GeneCards Identifiers for IP6K3 Gene

  • GC06M033798
  • GC06M033430

Summaries for IP6K3 Gene

Entrez Gene Summary for IP6K3 Gene

  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

GeneCards Summary for IP6K3 Gene

IP6K3 (Inositol Hexakisphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K2.

UniProtKB/Swiss-Prot for IP6K3 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K3 Gene

Genomics for IP6K3 Gene

Regulatory Elements for IP6K3 Gene

Genomic Location for IP6K3 Gene

33,721,638 bp from pter
33,746,985 bp from pter
25,348 bases
Minus strand

Genomic View for IP6K3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IP6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K3 Gene

Proteins for IP6K3 Gene

  • Protein details for IP6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol hexakisphosphate kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q96MQ9

    Protein attributes for IP6K3 Gene

    410 amino acids
    Molecular mass:
    46417 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71225.2; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

neXtProt entry for IP6K3 Gene

Proteomics data for IP6K3 Gene at MOPED

Selected DME Specific Peptides for IP6K3 Gene

Post-translational modifications for IP6K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IP6K3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IP6K3

Domains for IP6K3 Gene

Protein Domains for IP6K3 Gene


Suggested Antigen Peptide Sequences for IP6K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96PC2
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K3: view

No data available for Gene Families for IP6K3 Gene

Function for IP6K3 Gene

Molecular function for IP6K3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Enzyme Numbers (IUBMB) for IP6K3 Gene

Gene Ontology (GO) - Molecular Function for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000831 inositol hexakisphosphate 6-kinase activity IDA 11502751
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA --
GO:0052723 inositol hexakisphosphate 1-kinase activity IEA --
genes like me logo Genes that share ontologies with IP6K3: view

Phenotypes for IP6K3 Gene

genes like me logo Genes that share phenotypes with IP6K3: view

Animal Model Products

miRNA for IP6K3 Gene

miRTarBase miRNAs that target IP6K3

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for IP6K3 Gene

Localization for IP6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K3 Gene


Subcellular locations from

Jensen Localization Image for IP6K3 Gene COMPARTMENTS Subcellular localization image for IP6K3 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 11502751
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IP6K3: view

Pathways for IP6K3 Gene

genes like me logo Genes that share pathways with IP6K3: view

Pathways by source for IP6K3 Gene

Interacting Proteins for IP6K3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: ENSP00000293756 Q96PC2-IP6K3_HUMAN for IP6K3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11502751
GO:0032958 inositol phosphate biosynthetic process IDA 11502751
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046488 phosphatidylinositol metabolic process IDA 11502751
genes like me logo Genes that share ontologies with IP6K3: view

Compounds for IP6K3 Gene

(1) HMDB Compounds for IP6K3 Gene

Compound Synonyms Cas Number PubMed IDs
1-Diphosinositol pentakisphosphate
  • D-myo-Inositol, 2,3,4,5,6-pentakis(dihydrogen phosphate)
genes like me logo Genes that share compounds with IP6K3: view

Transcripts for IP6K3 Gene

Unigene Clusters for IP6K3 Gene

Inositol hexakisphosphate kinase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IP6K3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for IP6K3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IP6K3 Gene

mRNA expression in normal human tissues for IP6K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IP6K3 Gene

This gene is overexpressed in Muscle - Skeletal (32.5).

SOURCE GeneReport for Unigene cluster for IP6K3 Gene Hs.17253

mRNA Expression by UniProt/SwissProt for IP6K3 Gene

Tissue specificity: Detected in brain
genes like me logo Genes that share expressions with IP6K3: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for IP6K3 Gene

Orthologs for IP6K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UQCC2 35
  • 85.31 (n)
  • 82.73 (a)
MNF1 36
  • 83 (a)
(Canis familiaris)
Mammalia IP6K3 35
  • 85.67 (n)
  • 83.78 (a)
IP6K3 36
  • 84 (a)
(Mus musculus)
Mammalia Ip6k3 35
  • 82.18 (n)
  • 78.77 (a)
Ip6k3 16
Ip6k3 36
  • 78 (a)
(Pan troglodytes)
Mammalia IP6K3 35
  • 98.78 (n)
  • 98.78 (a)
IP6K3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ip6k3 35
  • 77.87 (n)
  • 72.83 (a)
(Monodelphis domestica)
Mammalia IP6K3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia IP6K3 36
  • 70 (a)
(Gallus gallus)
Aves IP6K3 35
  • 67.43 (n)
  • 62.92 (a)
IP6K3 36
  • 62 (a)
(Anolis carolinensis)
Reptilia IP6K3 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10082 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F30A10.3 36
  • 33 (a)
T20F7.3 36
  • 27 (a)
Y22D7AR.6 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 36
  • 11 (a)
KCS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
-- 36
  • 29 (a)
Species with no ortholog for IP6K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IP6K3 Gene

Gene Tree for IP6K3 (if available)
Gene Tree for IP6K3 (if available)

Paralogs for IP6K3 Gene

Paralogs for IP6K3 Gene

Selected SIMAP similar genes for IP6K3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IP6K3: view

Variants for IP6K3 Gene

Sequence variations from dbSNP and Humsavar for IP6K3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2966 -- 33,721,743(+) GGCAT(C/T)GTAAT utr-variant-3-prime
rs2967 -- 33,721,757(+) TTTCC(A/G)TACTG utr-variant-3-prime
rs471942 -- 33,729,008(+) ATTTC(C/T)CCAAC intron-variant, upstream-variant-2KB
rs482786 -- 33,739,822(+) TCTAC(C/T)CCAGG intron-variant
rs487835 -- 33,743,156(+) GCAGG(A/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IP6K3 Gene

Variant ID Type Subtype PubMed ID
dgv85n68 CNV Loss 17160897
nsv885772 CNV Loss 21882294
nsv509128 CNV Insertion 20534489

Relevant External Links for IP6K3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K3 Gene

Disorders for IP6K3 Gene

Relevant External Links for IP6K3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for IP6K3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IP6K3 Gene

Publications for IP6K3 Gene

  1. Identification and characterization of a novel inositol hexakisphosphate kinase. (PMID: 11502751) Saiardi A. … Snyder S.H. (J. Biol. Chem. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48
  4. Common genetic variants associate with serum phosphorus concentration. (PMID: 20558539) Kestenbaum B. … Fox C.S. (J. Am. Soc. Nephrol. 2010) 3 48
  5. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. (PMID: 23850713) Yang S.K. … Song K. (Gut 2014) 3

Products for IP6K3 Gene

Sources for IP6K3 Gene

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