Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IP6K3 Gene

protein-coding   GIFtS: 56
GCID: GC06M033689

Inositol Hexakisphosphate Kinase 3

(Previous name: inositol hexaphosphate kinase 3)
(Previous symbol: IHPK3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inositol Hexakisphosphate Kinase 31 2     EC 2.7.4.213 8
IHPK31 2 3 5     INSP6K32 5
Inositol Hexaphosphate Kinase 31 2 3     ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase2
InsP6 Kinase 32 3     

External Ids:    HGNC: 172691   Entrez Gene: 1172832   Ensembl: ENSG000001618967   OMIM: 6069935   UniProtKB: Q96PC23   

Export aliases for IP6K3 gene to outside databases

Previous GC identifers: GC06M033798 GC06M033430


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IP6K3 Gene:
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely
responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate
(InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing
results in multiple transcript variants encoding the same protein.(provided by RefSeq, Dec 2008)

GeneCards Summary for IP6K3 Gene: 
IP6K3 (inositol hexakisphosphate kinase 3) is a protein-coding gene. Diseases associated with IP6K3 include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Synthesis of IPs in the nucleus and Inositol phosphate metabolism. GO annotations related to this gene include inositol hexakisphosphate 1-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. An important paralog of this gene is IP6K1.

UniProtKB/Swiss-Prot: IP6K3_HUMAN, Q96PC2
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IP6K3 gene promoter:
         Pbx1a   p53   HTF   FOXD1   Pax-2   Pax-2a   AP-4   AREB6   Msx-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIP6K3 promoter sequence
   Search SABiosciences Chromatin IP Primers for IP6K3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IP6K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

IP6K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IP6K3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033689:  view genomic region     (about GC identifiers)

Start:
33,689,443 bp from pter      End:
33,714,762 bp from pter
Size:
25,320 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IP6K3_HUMAN, Q96PC2 (See protein sequence)
Recommended Name: Inositol hexakisphosphate kinase 3  
Size: 410 amino acids; 46417 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAB71225.2; Type=Frameshift; Positions=122;
Secondary accessions: Q96MQ9

Explore the universe of human proteins at neXtProt for IP6K3: NX_Q96PC2

Explore proteomics data for IP6K3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PC2

  • 4/5 DME Specific Peptides for IP6K3 (Q96PC2) (see all 5)
     CGMQVYQ  FGLENLI  SYRFYSSS  LDLKMGTRQ 

    IP6K3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IP6K3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136355.1  NP_473452.2  

    ENSEMBL proteins: 
     ENSP00000293756   ENSP00000398861  
    Reactome Protein details: Q96PC2
    Human Recombinant Protein Products for IP6K3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IP6K3
    OriGene Protein Over-expression Lysate for IP6K3
    OriGene MassSpec for IP6K3 
    OriGene Custom Protein Services for IP6K3
    GenScript Custom Purified and Recombinant Proteins Services for IP6K3
    Novus Biologicals IP6K3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11502751
    GO:0005829cytosol TAS--

    IP6K3 for ontologies           About GeneDecksing



    IP6K3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IP6K3
    GenScript Custom Superior Antibodies Services for IP6K3
    Novus Biologicals IP6K3 Antibody
    Abcam antibodies for IP6K3
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for IP6K3
    LSBio Antibodies in human, mouse, rat for IP6K3 

    Assay Products for IP6K3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IP6K3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IP6K3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005522 IPK

    Graphical View of Domain Structure for InterPro Entry Q96PC2

    ProtoNet protein and cluster: Q96PC2

    1 Blocks protein domain: IPB005522 Inositol polyphosphate kinase

    UniProtKB/Swiss-Prot: IP6K3_HUMAN, Q96PC2
    Similarity: Belongs to the inositol phosphokinase (IPK) family


    IP6K3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IP6K3_HUMAN, Q96PC2
    Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
    Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4
    Catalytic activity: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate
    1,2,3,4,6-pentakisphosphate
    Catalytic activity: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate
    tetrakisphosphate (isomeric configuration unknown)

         Enzyme Number (IUBMB): EC 2.7.4.211 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000831inositol hexakisphosphate 6-kinase activity IDA11502751
    GO:0000832inositol hexakisphosphate 5-kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity IEA--
    GO:0052723inositol hexakisphosphate 1-kinase activity IEA--
         
    IP6K3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for IP6K3:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IP6K3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IP6K3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IP6K3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IP6K3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IP6K3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate IP6K3 (see all 16):
    hsa-miR-30c hsa-miR-495 hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-7-1* hsa-miR-1252 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIP6K3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IP6K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IP6K3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IP6K3
    Sirion Biotech Customized adenovirus for overexpression of IP6K3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IP6K3 (see all 13)
    OriGene ORF clones in mouse, rat for IP6K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IP6K3 (NM_001142883)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IP6K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IP6K3
    Sirion Biotech Customized lentivirus for stable overexpression of IP6K3 
                         Customized lentivirus expression plasmids for stable overexpression of IP6K3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IP6K3
    Search LifeMap BioReagents cell lines for IP6K3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IP6K3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IP6K3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1inositol pyrophosphates biosynthesis
    inositol pyrophosphates biosynthesis0.57
    Synthesis of pyrophosphates in the cytosol0.42
    2Inositol phosphate metabolism
    superpathway of inositol phosphate compounds0.60
    3Synthesis of IP3 and IP4 in the cytosol
    Inositol phosphate metabolism0.57
    4Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for IP6K3
        inositol pyrophosphates biosynthesis
    superpathway of inositol phosphate compounds

    3        Reactome Pathways for IP6K3
        Metabolism
    Synthesis of pyrophosphates in the cytosol
    Inositol phosphate metabolism



    IP6K3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IP6K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/91 Interacting proteins for IP6K3 (Q96PC23 ENSP000002937564) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11502751
    GO:0032958inositol phosphate biosynthetic process IDA11502751
    GO:0043647inositol phosphate metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046488phosphatidylinositol metabolic process IDA11502751

    IP6K3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IP6K3

    1 HMDB Compound for IP6K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Diphosinositol pentakisphosphateD-myo-Inositol, 2,3,4,5,6-pentakis(dihydrogen phosphate);1-(trihydrogen diphosphate);Diphospho-myo-inositol pentakisphosphate 148077-18-3--

    Search CenterWatch for drugs/clinical trials and news about IP6K3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IP6K3 gene (2 alternative transcripts): 
    NM_001142883.1  NM_054111.4  

    Unigene Cluster for IP6K3:

    Inositol hexakisphosphate kinase 3
    Hs.17253  [show with all ESTs]
    Unigene Representative Sequence: NM_001142883
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293756 ENST00000451316(uc010jvf.2 uc003ofb.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IP6K3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate IP6K3 (see all 16):
    hsa-miR-30c hsa-miR-495 hsa-miR-30d hsa-miR-30a hsa-miR-298 hsa-miR-7-1* hsa-miR-1252 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidIP6K3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IP6K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IP6K3
    Clone
    Products:
         
    OriGene clones in human, mouse for IP6K3 (see all 13)
    OriGene ORF clones in mouse, rat for IP6K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IP6K3 (NM_001142883)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IP6K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IP6K3
    Sirion Biotech Customized lentivirus for stable overexpression of IP6K3 
                         Customized lentivirus expression plasmids for stable overexpression of IP6K3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IP6K3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IP6K3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IP6K3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IP6K3

    Additional mRNA sequence: 

    AF393812.1 AK056586.2 AK223572.1 AK289935.1 BC089389.1 

    2 DOTS entries:

    DT.211368  DT.40118654 

    24/41 AceView cDNA sequences (see all 41):

    AA344576 CR623666 AI075137 AA344601 BI756662 BX354420 CO248865 N52903 
    AW451702 AF393812 AK056586 H48857 BQ187027 NM_054111 BX396755 BX431911 
    BM662703 BX396754 BV192018 AA036643 BM973856 H71782 BX500702 CF552166 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IP6K3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -                                                               
    SP2:                    -     -           -     -     -     -     -                           
    SP3:                    -                                                                     
    SP4:                    -     -                                                               
    SP5:                          -                                                               


    ECgene alternative splicing isoforms for IP6K3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IP6K3 expression in normal human tissues (normalized intensities)      IP6K3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACGCGGCT
    IP6K3 Expression
    About this image


    IP6K3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Adipose (Muscoskeletal System)
             HyStem+BMP4-induced 7SMOO32 cells

    See IP6K3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IP6K3

    SOURCE GeneReport for Unigene cluster: Hs.17253

    UniProtKB/Swiss-Prot: IP6K3_HUMAN, Q96PC2
    Tissue specificity: Detected in brain

        SABiosciences Custom PCR Arrays for IP6K3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IP6K3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IP6K3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IP6K3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IP6K3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IP6K3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IP6K3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ip6k31 , 5 inositol hexaphosphate kinase 31, 5 81.31(n)1
    77.53(a)1
      17 (13.77 cM)5
    2714241  NM_173027.21  NP_766615.11 
     271439695 
    chicken
    (Gallus gallus)
    Aves IP6K31 inositol hexakisphosphate kinase 3 67.52(n)
    62.66(a)
      419908  XM_418033.3  XP_418033.2 
    lizard
    (Anolis carolinensis)
    Reptilia IP6K36
    Uncharacterized protein
    61(a)
    1 ↔ 1
    4(122995200-123025291)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100826
    --
    15(a)
    possible ortholog
    2R(17533682-17545440)
    worm
    (Caenorhabditis elegans)
    Secernentea F30A10.36
    Y22D7AR.66
    (see all 3)
    Protein Y22D7AR.6
    (see all 3)
    33(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    I(9492630-9494589)
    III(1672517-1676721)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KCS1(YDR017C)4 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate more   --   4(482267-479115) 851580  NP_010300.1 


    ENSEMBL Gene Tree for IP6K3 (if available)
    TreeFam Gene Tree for IP6K3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IP6K3 gene
    IP6K12  IPMK2  IP6K22  
    3 SIMAP similar genes for IP6K3 using alignment to 2 protein entries:     IP6K3_HUMAN (see all proteins):
    IP6K1    IHPK2    IP6K2

    IP6K3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/722 SNPs in IP6K3 are shown (see all 722)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870622861,2
    --33689047(+) GTGAAC/TCTGCT 2 -- ds50010--------
    rs1457099371,2
    --33689059(+) AGAAAC/GCCATA 2 -- ds50010--------
    rs1418650261,2
    C--33689101(+) TTTTT-/TGTTTT 2 -- ds50010--------
    rs1918083981,2
    C--33689106(+) GTTTTG/TTTTGT 2 -- ds50010--------
    rs752554541,2
    C,F--33689174(+) TGTGGA/GTAGTA 2 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1149116821,2
    F--33689185(+) ATTATC/TCATGA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs737433101,2
    C,F--33689299(+) CCACCA/GTTTCC 2 -- ds50013Minor allele frequency- G:0.04WA NA 240
    rs1840977071,2
    --33689467(+) ATTAAC/TAAATT 2 -- ut310--------
    rs1140781281,2
    C,F--33689474(+) AATTTA/TTTTCC 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs29661,2
    C,F,A,H--33689520(+) GGCATT/CGTAAT 2 -- ut3121Minor allele frequency- C:0.41MN EA NS NA WA 4256

    HapMap Linkage Disequilibrium report for IP6K3 (33689443 - 33714762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IP6K3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509128CNV Insertion20534489
    dgv85n68CNV Loss17160897
    nsv885772CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IP6K3
    DNA2.0 Custom Variant and Variant Library Synthesis for IP6K3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606993    OMIM disorders: --

    2 diseases for IP6K3:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus


    IP6K3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IP6K3
    Human Genome Epidemiology (HuGE) Navigator: IP6K3 (2 documents)

    Export disorders for IP6K3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IP6K3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IP6K3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel inositol hexakisphosphate kinase. (PubMed id 11502751)1, 2, 3, 9 Saiardi A.... Snyder S.H. (2001)
    2. Common genetic variants associate with serum phosphor us concentration. (PubMed id 20558539)1, 4 Kestenbaum B....Fox C.S. (2010)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117283 HGNC: 17269 AceView: IHPK3 Ensembl:ENSG00000161896 euGenes: HUgn117283
    ECgene: IP6K3 H-InvDB: IP6K3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IP6K3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IP6K3 gene:
    Search GeneIP for patents involving IP6K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IP6K3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IP6K3  
     OriGene MassSpec something-or-other for IP6K3   OriGene clones in human, mouse for IP6K3  
     OriGene qSTAR qPCR primer pairs in human, mouse for IP6K3   OriGene Purified Protein for IP6K3  
     OriGene ORF clones in mouse, rat for IP6K3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IP6K3   OriGene Custom Protein Services for IP6K3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IP6K3
     QIAGEN SeqTarget long-range PCR primers for resequencing IP6K3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IP6K3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IP6K3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IP6K3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IP6K3
     GenScript Custom Purified and Recombinant Proteins Services for IP6K3 GenScript cDNA clones with any tag delivered in your preferred vector for IP6K3
     GenScript Custom Assay Services for IP6K3 GenScript Custom Superior Antibodies Services for IP6K3
     GenScript Custom overexpressing Cell Line Services for IP6K3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in IP6K3 promoter
     Search Chromatin IP Primers for IP6K3
     RT2 qPCR Primer Assay in human, mouse, rat IP6K3
     Search GNC Networks for IP6K3
     SABiosciences Custom PCR Arrays for IP6K3
     Search Tocris compounds for IP6K3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     IP6K3 antibodies
     IP6K3 lysates
     Antibodies for IP6K3
     See all of Abcam's Antibodies, Kits and Proteins for IP6K3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for IP6K3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IP6K3
     SwitchGear 3'UTR luciferase reporter plasmids for IP6K3
     SwitchGear Promoter luciferase reporter plasmids for IP6K3
     Search ThermoFisher Antibodies for IP6K3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IP6K3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IP6K3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IP6K3
    Customized:
     lentivirus for stable overexpression of IP6K3
     lentivirus expression plasmids for stable overexpression of IP6K3
     adenovirus for overexpression of IP6K3
     LSBio Antibodies in human, mouse, rat for IP6K3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IP6K3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4