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Aliases for IP6K3 Gene

Aliases for IP6K3 Gene

  • Inositol Hexakisphosphate Kinase 3 2 3 5
  • Inositol Hexaphosphate Kinase 3 2 3 4
  • InsP6 Kinase 3 3 4
  • EC 2.7.4.21 4 58
  • IHPK3 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • INSP6K3 3

External Ids for IP6K3 Gene

Previous HGNC Symbols for IP6K3 Gene

  • IHPK3

Previous GeneCards Identifiers for IP6K3 Gene

  • GC06M033798
  • GC06M033430

Summaries for IP6K3 Gene

Entrez Gene Summary for IP6K3 Gene

  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

GeneCards Summary for IP6K3 Gene

IP6K3 (Inositol Hexakisphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K1.

UniProtKB/Swiss-Prot for IP6K3 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Additional gene information for IP6K3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K3 Gene

Genomics for IP6K3 Gene

Regulatory Elements for IP6K3 Gene

Enhancers for IP6K3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H033743 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +1.2 1187 5.2 HDGF ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 SLC30A9 LEMD2 BRD2 DAXX WDR46 RPS18 VPS52 RPS10 RXRB IP6K3 UQCC2
GH06H033710 1.4 ENCODE dbSUPER 26.1 +35.6 35574 2 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 IP6K3 UQCC2 LEMD2 LINC00336 RPS18 MIR3934
GH06H033837 1.7 Ensembl ENCODE dbSUPER 16.2 -92.9 -92916 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 LEMD2 VPS52 RXRB BRD2 WDR46 RING1 DAXX PHF1 HCG25 IP6K3
GH06H033608 1.3 Ensembl ENCODE dbSUPER 19.9 +136.6 136586 3.4 TFAP4 ZNF792 SAP130 ARID4B MAX KLF17 RARA ZNF316 ZNF600 RCOR1 BAK1 IP6K3 ITPR3 GGNBP1 HLA-DPA1 LEMD2 CUTA LINC00336
GH06H033691 1.3 Ensembl ENCODE dbSUPER 14.6 +52.0 52034 7.2 PKNOX1 KLF17 FEZF1 GLIS2 SCRT2 RUNX3 CREM NR2F2 ZFP69B MAFF UQCC2 IP6K3 BAK1 LEMD2 HLA-DPA1 RPS18 ITPR3 MIR3934 LOC105375023
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IP6K3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IP6K3 Gene

Genomic Locations for IP6K3 Gene
chr6:33,721,637-33,746,985
(GRCh38/hg38)
Size:
25,349 bases
Orientation:
Minus strand
chr6:33,689,443-33,714,762
(GRCh37/hg19)

Genomic View for IP6K3 Gene

Genes around IP6K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IP6K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IP6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K3 Gene

Proteins for IP6K3 Gene

  • Protein details for IP6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PC2-IP6K3_HUMAN
    Recommended name:
    Inositol hexakisphosphate kinase 3
    Protein Accession:
    Q96PC2
    Secondary Accessions:
    • Q96MQ9

    Protein attributes for IP6K3 Gene

    Size:
    410 amino acids
    Molecular mass:
    46417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71225.2; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

neXtProt entry for IP6K3 Gene

Selected DME Specific Peptides for IP6K3 Gene

Q96PC2:
  • SYRFYSSS
  • SREQRFYESLP
  • CGMQVYQ
  • LDLKMGTRQ
  • FGLENLI

Post-translational modifications for IP6K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IP6K3 Gene

Domains & Families for IP6K3 Gene

Gene Families for IP6K3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for IP6K3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IP6K3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PC2

UniProtKB/Swiss-Prot:

IP6K3_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K3: view

Function for IP6K3 Gene

Molecular function for IP6K3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Enzyme Numbers (IUBMB) for IP6K3 Gene

Phenotypes From GWAS Catalog for IP6K3 Gene

Gene Ontology (GO) - Molecular Function for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity TAS --
GO:0000828 inositol hexakisphosphate kinase activity TAS,IDA --
GO:0000829 inositol heptakisphosphate kinase activity TAS --
GO:0000831 inositol hexakisphosphate 6-kinase activity IDA 11502751
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
genes like me logo Genes that share ontologies with IP6K3: view
genes like me logo Genes that share phenotypes with IP6K3: view

Animal Models for IP6K3 Gene

MGI Knock Outs for IP6K3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IP6K3 Gene

Localization for IP6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IP6K3 gene
Compartment Confidence
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA,IEA 11502751
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IP6K3: view

Pathways & Interactions for IP6K3 Gene

genes like me logo Genes that share pathways with IP6K3: view

Pathways by source for IP6K3 Gene

Gene Ontology (GO) - Biological Process for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11502751
GO:0016310 phosphorylation IEA --
GO:0032958 inositol phosphate biosynthetic process IDA 11502751
GO:0043647 inositol phosphate metabolic process TAS --
GO:0046488 phosphatidylinositol metabolic process IDA 11502751
genes like me logo Genes that share ontologies with IP6K3: view

No data available for SIGNOR curated interactions for IP6K3 Gene

Drugs & Compounds for IP6K3 Gene

(1) Drugs for IP6K3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0

(2) Additional Compounds for IP6K3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Myo-inositol hexakisphosphate
  • 1D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-Myo-inositol hexakisphosphate
  • D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
genes like me logo Genes that share compounds with IP6K3: view

Transcripts for IP6K3 Gene

Unigene Clusters for IP6K3 Gene

Inositol hexakisphosphate kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for IP6K3 Gene

GeneLoc Exon Structure for
IP6K3
ECgene alternative splicing isoforms for
IP6K3

Expression for IP6K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IP6K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IP6K3 Gene

This gene is overexpressed in Muscle - Skeletal (x32.5).

NURSA nuclear receptor signaling pathways regulating expression of IP6K3 Gene:

IP6K3

SOURCE GeneReport for Unigene cluster for IP6K3 Gene:

Hs.17253

mRNA Expression by UniProt/SwissProt for IP6K3 Gene:

Q96PC2-IP6K3_HUMAN
Tissue specificity: Detected in brain.

Evidence on tissue expression from TISSUES for IP6K3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IP6K3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IP6K3 Gene

Orthologs for IP6K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IP6K3 33 34
  • 98.78 (n)
dog
(Canis familiaris)
Mammalia IP6K3 33 34
  • 85.67 (n)
cow
(Bos Taurus)
Mammalia UQCC2 33
  • 85.31 (n)
MNF1 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ip6k3 33 16 34
  • 82.18 (n)
rat
(Rattus norvegicus)
Mammalia Ip6k3 33
  • 77.87 (n)
oppossum
(Monodelphis domestica)
Mammalia IP6K3 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IP6K3 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves IP6K3 33 34
  • 67.43 (n)
lizard
(Anolis carolinensis)
Reptilia IP6K3 34
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10082 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30A10.3 34
  • 33 (a)
ManyToMany
Y22D7AR.6 34
  • 29 (a)
ManyToMany
T20F7.3 34
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 34 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for IP6K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IP6K3 Gene

ENSEMBL:
Gene Tree for IP6K3 (if available)
TreeFam:
Gene Tree for IP6K3 (if available)

Paralogs for IP6K3 Gene

Paralogs for IP6K3 Gene

(3) SIMAP similar genes for IP6K3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IP6K3: view

Variants for IP6K3 Gene

Sequence variations from dbSNP and Humsavar for IP6K3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000092290 -- 33,727,765(+) GTACT(G/T)CCTCC intron-variant
rs1000123645 -- 33,733,596(+) GGCTA(A/C)GTTTA intron-variant
rs1000159912 -- 33,745,577(+) GGTCG(A/G)GGGGC intron-variant
rs1000161612 -- 33,744,852(+) CTTAA(C/T)CAGGG intron-variant
rs1000218044 -- 33,736,004(+) TGGGA(C/T)TACAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IP6K3 Gene

Variant ID Type Subtype PubMed ID
dgv85n68 CNV loss 17160897
esv3608630 CNV gain 21293372
nsv509128 CNV insertion 20534489

Variation tolerance for IP6K3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IP6K3 Gene

Human Gene Mutation Database (HGMD)
IP6K3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IP6K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K3 Gene

Disorders for IP6K3 Gene

Relevant External Links for IP6K3

Genetic Association Database (GAD)
IP6K3
Human Genome Epidemiology (HuGE) Navigator
IP6K3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IP6K3

No disorders were found for IP6K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K3 Gene

Publications for IP6K3 Gene

  1. Identification and characterization of a novel inositol hexakisphosphate kinase. (PMID: 11502751) Saiardi A … Snyder SH (The Journal of biological chemistry 2001) 2 3 4 22 60
  2. Common genetic variants associate with serum phosphorus concentration. (PMID: 20558539) Kestenbaum B … Fox CS (Journal of the American Society of Nephrology : JASN 2010) 3 45 60
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for IP6K3 Gene

  • Addgene plasmids for IP6K3

Sources for IP6K3 Gene

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