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Aliases for IP6K3 Gene

Aliases for IP6K3 Gene

  • Inositol Hexakisphosphate Kinase 3 2 3 5
  • Inositol Hexaphosphate Kinase 3 2 3 4
  • InsP6 Kinase 3 3 4
  • EC 2.7.4.21 4 63
  • IHPK3 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • INSP6K3 3

External Ids for IP6K3 Gene

Previous HGNC Symbols for IP6K3 Gene

  • IHPK3

Previous GeneCards Identifiers for IP6K3 Gene

  • GC06M033798
  • GC06M033430

Summaries for IP6K3 Gene

Entrez Gene Summary for IP6K3 Gene

  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

GeneCards Summary for IP6K3 Gene

IP6K3 (Inositol Hexakisphosphate Kinase 3) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Inositol phosphate metabolism (REACTOME). GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K2.

UniProtKB/Swiss-Prot for IP6K3 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K3 Gene

Genomics for IP6K3 Gene

Regulatory Elements for IP6K3 Gene

Enhancers for IP6K3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IP6K3 on UCSC Golden Path with GeneCards custom track

Promoters for IP6K3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IP6K3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IP6K3 Gene

Chromosome:
6
Start:
33,721,637 bp from pter
End:
33,746,985 bp from pter
Size:
25,349 bases
Orientation:
Minus strand

Genomic View for IP6K3 Gene

Genes around IP6K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IP6K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IP6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K3 Gene

Proteins for IP6K3 Gene

  • Protein details for IP6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PC2-IP6K3_HUMAN
    Recommended name:
    Inositol hexakisphosphate kinase 3
    Protein Accession:
    Q96PC2
    Secondary Accessions:
    • Q96MQ9

    Protein attributes for IP6K3 Gene

    Size:
    410 amino acids
    Molecular mass:
    46417 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71225.2; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

neXtProt entry for IP6K3 Gene

Proteomics data for IP6K3 Gene at MOPED

Selected DME Specific Peptides for IP6K3 Gene

Post-translational modifications for IP6K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IP6K3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IP6K3 (IHPK3)
  • Abcam antibodies for IHPK3
  • Santa Cruz Biotechnology (SCBT) Antibodies for IP6K3

Domains & Families for IP6K3 Gene

Protein Domains for IP6K3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IP6K3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PC2

UniProtKB/Swiss-Prot:

IP6K3_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K3: view

No data available for Gene Families for IP6K3 Gene

Function for IP6K3 Gene

Molecular function for IP6K3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Enzyme Numbers (IUBMB) for IP6K3 Gene

Gene Ontology (GO) - Molecular Function for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000828 inositol hexakisphosphate kinase activity TAS --
GO:0000829 inositol heptakisphosphate kinase activity TAS --
GO:0000831 inositol hexakisphosphate 6-kinase activity IDA 11502751
GO:0052723 inositol hexakisphosphate 1-kinase activity IEA --
GO:0052724 inositol hexakisphosphate 3-kinase activity IEA --
genes like me logo Genes that share ontologies with IP6K3: view
genes like me logo Genes that share phenotypes with IP6K3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IP6K3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IP6K3 Gene

Localization for IP6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IP6K3 Gene COMPARTMENTS Subcellular localization image for IP6K3 gene
Compartment Confidence
cytosol 5
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for IP6K3 Gene

Pathways & Interactions for IP6K3 Gene

genes like me logo Genes that share pathways with IP6K3: view

Pathways by source for IP6K3 Gene

1 Cell Signaling Technology pathway for IP6K3 Gene

Interacting Proteins for IP6K3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000293756%0d%0a9606.ENSP00000323780%0d%0a9606.ENSP00000287996%0d%0a9606.ENSP00000338352%0d%0a9606.ENSP00000267615%0d%0a9606.ENSP00000380129%0d%0a
Selected Interacting proteins: ENSP00000293756 Q96PC2-IP6K3_HUMAN for IP6K3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IP6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032958 inositol phosphate biosynthetic process IDA 11502751
genes like me logo Genes that share ontologies with IP6K3: view

No data available for SIGNOR curated interactions for IP6K3 Gene

Drugs & Compounds for IP6K3 Gene

(1) Drugs for IP6K3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for IP6K3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Myo-inositol hexakisphosphate
  • 1D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-Myo-inositol hexakisphosphate
  • D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
genes like me logo Genes that share compounds with IP6K3: view

Transcripts for IP6K3 Gene

Unigene Clusters for IP6K3 Gene

Inositol hexakisphosphate kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - - - - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for IP6K3 Gene

GeneLoc Exon Structure for
IP6K3
ECgene alternative splicing isoforms for
IP6K3

Expression for IP6K3 Gene

mRNA expression in normal human tissues for IP6K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IP6K3 Gene

This gene is overexpressed in Muscle - Skeletal (x32.5).

SOURCE GeneReport for Unigene cluster for IP6K3 Gene Hs.17253

mRNA Expression by UniProt/SwissProt for IP6K3 Gene

Q96PC2-IP6K3_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with IP6K3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IP6K3 Gene

Orthologs for IP6K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UQCC2 35
  • 85.31 (n)
  • 82.73 (a)
MNF1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IP6K3 35
  • 85.67 (n)
  • 83.78 (a)
IP6K3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ip6k3 35
  • 82.18 (n)
  • 78.77 (a)
Ip6k3 16
Ip6k3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IP6K3 35
  • 98.78 (n)
  • 98.78 (a)
IP6K3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ip6k3 35
  • 77.87 (n)
  • 72.83 (a)
oppossum
(Monodelphis domestica)
Mammalia IP6K3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IP6K3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves IP6K3 35
  • 67.43 (n)
  • 62.92 (a)
IP6K3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IP6K3 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10082 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30A10.3 36
  • 33 (a)
ManyToMany
T20F7.3 36
  • 27 (a)
ManyToMany
Y22D7AR.6 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 36
  • 11 (a)
OneToMany
KCS1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for IP6K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for IP6K3 Gene

ENSEMBL:
Gene Tree for IP6K3 (if available)
TreeFam:
Gene Tree for IP6K3 (if available)

Paralogs for IP6K3 Gene

Paralogs for IP6K3 Gene

(3) SIMAP similar genes for IP6K3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IP6K3: view

Variants for IP6K3 Gene

Sequence variations from dbSNP and Humsavar for IP6K3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs34431226 - 33,735,299(+) GAACC(A/G)CTTCA reference, missense
rs34573836 - 33,723,030(+) GGAGG(A/G)CCCGG downstream-variant-500B, reference, missense
rs4713668 - 33,723,019(+) AATGA(C/T)AGAGA downstream-variant-500B, reference, missense
rs34343647 - 33,722,820(+) TCCAG(G/T)AGCCC downstream-variant-500B, reference, missense
rs6457740 -- 33,729,348(+) CTCCT(A/G)ATGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IP6K3 Gene

Variant ID Type Subtype PubMed ID
dgv85n68 CNV Loss 17160897
nsv885772 CNV Loss 21882294
nsv509128 CNV Insertion 20534489

Variation tolerance for IP6K3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IP6K3 Gene

Disorders for IP6K3 Gene

Relevant External Links for IP6K3

Genetic Association Database (GAD)
IP6K3
Human Genome Epidemiology (HuGE) Navigator
IP6K3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IP6K3

No disorders were found for IP6K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K3 Gene

Publications for IP6K3 Gene

  1. Identification and characterization of a novel inositol hexakisphosphate kinase. (PMID: 11502751) Saiardi A. … Snyder S.H. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. (PMID: 23850713) Yang S.K. … Song K. (Gut 2014) 3
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Common genetic variants associate with serum phosphorus concentration. (PMID: 20558539) Kestenbaum B. … Fox C.S. (J. Am. Soc. Nephrol. 2010) 3

Products for IP6K3 Gene

Sources for IP6K3 Gene

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