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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IP6K2 Gene

protein-coding   GIFtS: 59
GCID: GC03M048725

inositol hexakisphosphate kinase 2

(Previous name: inositol hexaphosphate kinase 2 )
(Previous symbol: IHPK2)
 Explore 6 diseases affiliated with
IP6K2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IP6K2    

Aliases
for IP6K2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inositol Hexakisphosphate Kinase 21 2     PIUS2
IHPK21 2 3 5     ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase2
Inositol Hexaphosphate Kinase 21 2     Pi Uptake Stimulator2
InsP6 Kinase 22 3     PiUS3
EC 2.7.4.213 8     P(I)-Uptake Stimulator3

External Ids:    HGNC: 173131   Entrez Gene: 514472   Ensembl: ENSG000000687457   OMIM: 6069925   UniProtKB: Q9UHH93   

Export aliases for IP6K2 gene to outside databases

Previous GC identifer: GC03M048700


Summaries
for IP6K2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IP6K2:
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible
for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It
may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic
activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants
encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts
1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Gene Wiki entry for IP6K2 (IHPK2)


Genomic Views
for IP6K2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IP6K2 gene promoter:
         MAZR   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   MIF-1   POU3F2   NF-AT4   NF-AT2   FOXJ2 (long isoform)   NF-AT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IP6K2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IP6K2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IP6K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

IP6K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IP6K2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048725:  view genomic region     (about GC identifiers)

Start:
 48,725,436 bp from pter      End:
 48,777,786 bp from pter
Size:
 52,351 bases      Orientation:
 minus strand

Proteins
for IP6K2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9 (See protein sequence)
Recommended Name: Inositol hexakisphosphate kinase 2  
Size: 426 amino acids; 49186 Da
Subcellular location: Nucleus
Secondary accessions: A8K3B1 B4E3G6 G8JLL6 Q6P0N8 Q9BSZ6 Q9BUW3 Q9H4P7 Q9NT63 Q9UFU6
Alternative splicing: 6 isoforms:  Q9UHH9-1   Q9UHH9-2   Q9UHH9-3   Q9UHH9-4   Q9UHH9-5   Q9UHH9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IP6K2: NX_Q9UHH9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHH9

    • 4/5 DME Specific Peptides for IP6K2 (Q9UHH9) (see all 5)
     CGMQVYQ  SYRFYSSS  LDLKMGTRQ  VDVRMIDFAH 

    IP6K2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_001005909.1  NP_001005910.1  NP_001005911.1  NP_001139650.1  NP_001139651.1  NP_001177245.1  NP_001177246.1  NP_057375.2  

    ENSEMBL proteins: 
     ENSP00000331103   ENSP00000411776   ENSP00000414428   ENSP00000389761   ENSP00000403968  
     ENSP00000395819   ENSP00000412121   ENSP00000341925   ENSP00000396904   ENSP00000387759  
     ENSP00000414139   ENSP00000393077   ENSP00000396203   ENSP00000394488   ENSP00000399052  
     ENSP00000410454   ENSP00000389755   ENSP00000388116   ENSP00000410950   ENSP00000387394  
     ENSP00000393797   ENSP00000388420   ENSP00000406357   ENSP00000400812  
    Reactome Protein details: Q9UHH9
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IP6K2
    OriGene Protein Over-expression Lysate (see all 3): IP6K2
    OriGene Custom Protein Services for IP6K2 
    GenScript Custom Purified and Recombinant Proteins Services for IP6K2
    Novus Biologicals IP6K2 Proteins
    Novus Biologicals IP6K2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IP6K2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0045111intermediate filament cytoskeleton IDA--


    IP6K2 for ontologies           About GeneDecksing



    IP6K2 Antibody Products: 
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    Abcam antibodies for IP6K2 
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    ThermoFisher Antibody for IP6K2

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    Uscn ELISAs and CLIAs for IP6K2

    Protein Domains /
    Families
    for IP6K2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IP6K2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005522 IPK

    Graphical View of Domain Structure for InterPro Entry Q9UHH9

    ProtoNet protein and cluster: Q9UHH9

    1 Blocks protein family: IPB005522 Inositol polyphosphate kinase

    UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9
    Similarity: Belongs to the inositol phosphokinase (IPK) family


    Function
    for IP6K2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9
    Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts
    1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4
    Catalytic activity: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate
    1,2,3,4,6-pentakisphosphate
    Catalytic activity: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate
    tetrakisphosphate (isomeric configuration unknown)

    Enzyme Number (IUBMB): EC 2.7.4.211 2

    miRNA
    Products:            		miRTarBase miRNAs that target IP6K2:
    hsa-mir-1 (MIRT003850)

    OriGene 3'-UTR Clone (see all 6): IP6K2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IP6K2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate IP6K2 (see all 16):
    hsa-miR-345 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-3673 hsa-miR-206 hsa-miR-892b hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IP6K2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IP6K2 (see all 4)
    OriGene shRNA RFP: IP6K2
    OriGene siRNA: IP6K2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IP6K2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IP6K2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IP6K2 (see all 10)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IP6K2 (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 8): IP6K2 (NM_016291)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IP6K2 

    Cell Line
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    Search LifeMap BioReagents cell lines for IP6K2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IP6K2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000832inositol hexakisphosphate 5-kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity IEA--
    GO:0052723inositol hexakisphosphate 1-kinase activity IEA--
    GO:0052724inositol hexakisphosphate 3-kinase activity IEA--


    IP6K2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ip6k2tm1Dlin for IP6K2
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ip6k2):
     cellular  digestive/alimentary  homeostasis/metabolism  mortality/aging  tumorigenesis 

    IP6K2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IP6K2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    2inositol pyrophosphates biosynthesis
    		inositol pyrophosphates biosynthesis1.00
    		Synthesis of IPs in the nucleus0.57
    3Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    4Immune System
    		Immune System1.00
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for IP6K2 
        inositol pyrophosphates biosynthesis
    superpathway of inositol phosphate compounds

    5/8        Reactome Pathways for IP6K2 (see all 8)
        Synthesis of IPs in the nucleus
    Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Metabolism
    Interferon Signaling



    IP6K2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IP6K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for IP6K2 (Q9UHH92, 3 ENSP000003311034) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-67071 I2D: score=5 STRING: ENSP00000345494
    LNX2Q8N4483I2D: score=1 
    IP6K1ENSP000003237804STRING: ENSP00000323780
    IP6K3ENSP000002937564STRING: ENSP00000293756
    IPMKENSP000003630464STRING: ENSP00000363046
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006817phosphate ion transport IEA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0030308negative regulation of cell growth IMP11337497
    GO:0043065positive regulation of apoptotic process IMP11337497
    GO:0046854phosphatidylinositol phosphorylation IDA10574768


    IP6K2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IP6K2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IP6K2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IP6K2

    1 HMDB Compound for IP6K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Diphosinositol pentakisphosphateD-myo-Inositol, 2,3,4,5,6-pentakis(dihydrogen phosphate);1-(trihydrogen diphosphate);Diphospho-myo-inositol pentakisphosphate 148077-18-3--
    1 Novoseek chemical compound relationship for IP6K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phytate 86.8 18 11337497 (2), 11896621 (2), 18195352 (2), 15634191 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about IP6K2 

    Transcripts
    for IP6K2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IP6K2 gene (10 alternative transcripts): 
    NM_001005909.2  NM_001005910.2  NM_001005911.2  NM_001146178.2  NM_001146179.2  NM_001190316.1  NM_001190317.1  NM_016291.3  
    NM_001005912.1  NM_001005913.1  

    Unigene Cluster for IP6K2:

    Inositol hexakisphosphate kinase 2
    Hs.595983  [show with all ESTs]
    Unigene Representative Sequence: NM_001190316
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000328631(uc003cuq.3 uc003cup.3) ENST00000479914 ENST00000491686
    ENST00000449563 ENST00000413654 ENST00000443853 ENST00000437427 ENST00000412850
    ENST00000454335 ENST00000340879 ENST00000433104(uc011bbr.2 uc011bbq.2 uc011bbs.2 uc003cut.3 uc003cus.3 uc003cur.3)
    ENST00000416707 ENST00000431721(uc011bbv.2 uc011bbu.2 uc011bbt.2)
    ENST00000449610 ENST00000413298 ENST00000450045 ENST00000446860 ENST00000455545


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 6): IP6K2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IP6K2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate IP6K2 (see all 16):
    hsa-miR-345 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-3673 hsa-miR-206 hsa-miR-892b hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmid: IP6K2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IP6K2 (see all 4)
    OriGene shRNA RFP: IP6K2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IP6K2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF177145.1 AK024045.1 AK097016.1 AK290526.1 AK291501.1 AK304714.1 AK311013.1 AK315204.1 
    AL117458.1 AL137514.1 AY007091.1 BC004469.2 BC019694.1 BC065533.1 BX537544.1 NR_027437.2 
    NR_027438.2 

    24/35 DOTS entries (see all 35):

    DT.212524  DT.100880618  DT.100880624  DT.92454125  DT.100880631  DT.101968381  DT.100880611  DT.120924709 
    DT.120924764  DT.100030570  DT.120924716  DT.100880623  DT.92045081  DT.40282481  DT.92454113  DT.92454126 
    DT.100030569  DT.100838157  DT.100880621  DT.120924712  DT.95273222  DT.120924715  DT.100669378  DT.100686752 

    24/544 AceView cDNA sequences (see all 544):

    CR592174 AI057549 BM792355 AW025497 AI220933 CR609217 AF303581 BI087294 
    BM875400 AI913417 AF178432 AI936913 AL560230 BI758677 CF786019 CR616816 
    BM049346 BM826938 CB997431 BG747179 BQ886744 BM512280 CR606469 AI829980 

    GeneLoc Exon Structure

    5/36 Alternative Splicing Database (ASD) splice patterns (SP) for IP6K2 (see all 36)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a ·
    SP1:                                -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -   
    SP2:                                -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                -     -     -     -     -     -     -                       -     -     -           -     -     -     -           -         
    SP4:                                -     -           -     -     -     -                       -     -     -     -     -                                       
    SP5:                                -     -     -     -     -     -     -                       -     -     -     -     -                       -     -         

    ExUns: 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
    SP1:  -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for IP6K2

    Expression
    for IP6K2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IP6K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGCTGTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IP6K2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular CondyleBone
    BoneMandibular FossaBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IP6K2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IP6K2

    SOURCE GeneReport for Unigene cluster: Hs.595983
        SABiosciences Custom PCR Arrays for IP6K2
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    In Situ
    Assay Products:     
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    Orthologs
    for IP6K2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IP6K2 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IP6K21 inositol hexakisphosphate kinase 2 78.54(n)
    86.08(a)    		   416010  NM_001030596.2  NP_001025767.2 
    lizard
    (Anolis carolinensis)    		 Reptilia IP6K26
    		 --
    		 84(a)
    		 1 ↔ 1
    		 2(163961204-163968649)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.92272 Xenopus laevis transcribed sequence with weak similarity more 77(n)    CD254943.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC059642.12   -- 75.37(n)    BC059642.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG100821 CG10082 52.56(n)
    43.01(a)    		   37465  NM_166466.2  NP_726095.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea F30A10.36
    T20F7.36
    (see all 3)    		 Protein T20F7.3
    (see all 3)    		 34(a)
    27(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 I(9492622-9494581)
    X(16860323-16861314)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATIPK2A6
    ATIPK2BETA6
    		 inositol polyphosphate multikinase beta
    		 26(a)
    24(a)
    		 many ↔ many
    many ↔ many
    		 5(2330385-2332281)
    5(24813729-24815443)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 inositol hexaphosphate kinase, putative, expressed...
    		 26(a)
    		 1 → many
    		 2(19116035-19119974)


    ENSEMBL Gene Tree for IP6K2 (if available)
    TreeFam Gene Tree for IP6K2 (if available) 

    Paralogs
    for IP6K2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IP6K2 gene
    IP6K32  IP6K12  IPMK2  
    3 SIMAP similar genes for IP6K2 using alignment to 15 protein entries:     IP6K2_HUMAN (see all proteins):
    IHPK2    IP6K1    IP6K3

    IP6K2 for paralogs           About GeneDecksing



    Genomic Variants
    for IP6K2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/456 NCBI SNPs in IP6K2 are shown (see all 456)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1838973171,2
    		--48724997(+) CAATGC/GACCAG 4 -- ds5001 us2k10--------
    rs98110271,2
    		C,F,A,H,--48725014(+) GGCTAG/CAGACC 4 -- ds5001 us2k114Minor allele frequency- C:0.11NS EA NA WA CSA 668
    rs1467341541,2
    		--48725146(+) GCATAC/TGGCCC 4 -- ds5001 us2k10--------
    rs1882788691,2
    		--48725291(+) TACACC/TATGCC 4 -- ds5001 us2k10--------
    rs1825641821,2
    		--48725344(+) AGCCAA/GGAGAA 2 -- ds50010--------
    rs1166001471,2
    		C,F,--48725492(+) AGGTAT/CCATCA 2 -- ut311Minor allele frequency- C:0.04WA 118
    rs1870126911,2
    		--48725517(+) TTGAAG/TAAATA 2 -- ut310--------
    rs10489401,2
    		C,F,H,--48725707(-) GGAGTA/C/GAGCTT 6 * S syn1 stop-lost13MN NS EA NA CSA EU 6662
    rs1411355631,2
    		F--48725799(+) ACCACG/AGTGTC 4 /T syn11Minor allele frequency- A:0.00NA 4552
    rs1430541851,2
    		C,F--48725959(+) GGACCA/GCTTCG 4 A V mis12Minor allele frequency- G:0.00NA EU 5853

    HapMap Linkage Disequilibrium report for IP6K2 (48725436 - 48777786 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IP6K2
         1 CNV: 9448

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    Disorders / Diseases
    for IP6K2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IP6K2 for disorders           About GeneDecksing

    OMIM gene information: 606992    OMIM disorders: --

    6 diseases for IP6K2:    About MalaCards
    ovarian cancer    intrahepatic cholangiocarcinoma    ovarian carcinoma    cholangiocarcinoma
    carcinoma    malaria

    2 Novoseek disease relationships for IP6K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 66.3 10 11896621 (3), 15634191 (3), 11337497 (2), 17379600 (1)
    tumors 0 2 11896621 (1), 17379600 (1)


    Export disorders for IP6K2 gene to outside databases

    Publications
    for IP6K2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IP6K2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with IP6K2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. (PubMed id 10574768)1, 2, 3 Saiardi A....Snyder S.H. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and characterization of a novel inositol hexakisphosphate kinase. (PubMed id 11502751)1, 2 Saiardi A.... Snyder S.H. (2001)
    5. Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. (PubMed id 17379600)1, 9 Morrison B.H....Lindner D.J. (2007)
    6. Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. (PubMed id 11896621)1, 9 Morrison B.H....Lindner D.J. (2002)
    7. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. (PubMed id 18195352)1, 9 Chakraborty A....Snyder S.H. (2008)
    8. Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. (PubMed id 11337497)1, 9 Morrison B.H....Lindner D.J. (2001)
    9. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. (PubMed id 15533939)1, 9 Nagata E....Snyder S.H. (2005)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for IP6K2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IP6K2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51447 HGNC: 17313 AceView: CELSR3 Ensembl:ENSG00000068745 euGenes: HUgn51447
    ECgene: IP6K2 H-InvDB: IP6K2

    Other Databases showing IP6K2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IP6K2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IP6K2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IP6K2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IP6K2 gene:
    Search GeneIP for patents involving IP6K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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