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IP6K2 Gene

protein-coding   GIFtS: 58
GCID: GC03M048725

Inositol Hexakisphosphate Kinase 2

(Previous name: inositol hexaphosphate kinase 2)
(Previous symbol: IHPK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inositol Hexakisphosphate Kinase 21 2     PIUS2
IHPK21 2 3 5     ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase2
Inositol Hexaphosphate Kinase 21 2     Pi Uptake Stimulator2
InsP6 Kinase 22 3     PiUS3
EC 2.7.4.213 8     P(I)-Uptake Stimulator3

External Ids:    HGNC: 173131   Entrez Gene: 514472   Ensembl: ENSG000000687457   OMIM: 6069925   UniProtKB: Q9UHH93   

Export aliases for IP6K2 gene to outside databases

Previous GC identifer: GC03M048700


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IP6K2 Gene:
This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely
responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate
(InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth
suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for IP6K2 Gene:
IP6K2 (inositol hexakisphosphate kinase 2) is a protein-coding gene. Diseases associated with IP6K2 include ovarian cancer, and labyrinthitis. GO annotations related to this gene include inositol hexakisphosphate 1-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. An important paralog of this gene is IP6K3.

UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Gene Wiki entry for IP6K2 (IHPK2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IP6K2 gene promoter:
         MAZR   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   MIF-1   POU3F2   NF-AT4   NF-AT2   FOXJ2 (long isoform)   NF-AT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IP6K2 promoter sequence
   Search Chromatin IP Primers for IP6K2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IP6K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

IP6K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IP6K2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048725:  view genomic region     (about GC identifiers)

Start:
48,725,436 bp from pter      End:
48,777,786 bp from pter
Size:
52,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9 (See protein sequence)
Recommended Name: Inositol hexakisphosphate kinase 2  
Size: 426 amino acids; 49186 Da
Secondary accessions: A8K3B1 B4E3G6 G8JLL6 Q6P0N8 Q9BSZ6 Q9BUW3 Q9H4P7 Q9NT63 Q9UFU6
Alternative splicing: 6 isoforms:  Q9UHH9-1   Q9UHH9-2   Q9UHH9-3   Q9UHH9-4   Q9UHH9-5   Q9UHH9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IP6K2: NX_Q9UHH9

Explore proteomics data for IP6K2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys42, Lys182, Lys202, Lys222, Lys286
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IP6K2 (Q9UHH9) (see all 5)
     CGMQVYQ  SYRFYSSS  LDLKMGTRQ  VDVRMIDFAH 


    See IP6K2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001005909.1  NP_001005910.1  NP_001005911.1  NP_001139650.1  NP_001139651.1  NP_001177245.1  NP_001177246.1  NP_057375.2  

    ENSEMBL proteins: 
     ENSP00000331103   ENSP00000411776   ENSP00000414428   ENSP00000389761   ENSP00000403968  
     ENSP00000395819   ENSP00000412121   ENSP00000341925   ENSP00000396904   ENSP00000387759  
     ENSP00000414139   ENSP00000393077   ENSP00000396203   ENSP00000394488   ENSP00000399052  
     ENSP00000410454   ENSP00000389755   ENSP00000388116   ENSP00000410950   ENSP00000387394  
     ENSP00000393797   ENSP00000388420   ENSP00000406357   ENSP00000400812  
    Reactome Protein details: Q9UHH9

    IP6K2 Human Recombinant Protein Products:

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    Novus Biologicals IP6K2 Proteins
    Novus Biologicals IP6K2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IP6K2 Antibody Products:

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    Abcam antibodies for IP6K2
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    ThermoFisher Antibodies for IP6K2
    LSBio Antibodies in human, mouse, rat for IP6K2

    IP6K2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IP6K2
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005522 IPK

    Graphical View of Domain Structure for InterPro Entry Q9UHH9

    ProtoNet protein and cluster: Q9UHH9

    1 Blocks protein domain: IPB005522 Inositol polyphosphate kinase

    UniProtKB/Swiss-Prot: IP6K2_HUMAN, Q9UHH9
    Similarity: Belongs to the inositol phosphokinase (IPK) family


    IP6K2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IP6K2_HUMAN, Q9UHH9
    Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
    Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4
    Catalytic activity: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate
    1,2,3,4,6-pentakisphosphate
    Catalytic activity: ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol
    1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

         Enzyme Number (IUBMB): EC 2.7.4.211 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000832inositol hexakisphosphate 5-kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0008440inositol-1,4,5-trisphosphate 3-kinase activity IEA--
    GO:0052723inositol hexakisphosphate 1-kinase activity IEA--
    GO:0052724inositol hexakisphosphate 3-kinase activity IEA--
         
    IP6K2 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ip6k2):
     cellular  digestive/alimentary  homeostasis/metabolism  mortality/aging  tumorigenesis 

    IP6K2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ip6k2tm1Dlin for IP6K2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IP6K2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IP6K2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IP6K2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IP6K2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IP6K2:
    hsa-mir-18a-3p (MIRT040826), hsa-mir-1 (MIRT003850), hsa-mir-125a-3p (MIRT038635), hsa-mir-98-5p (MIRT027801)

    Block miRNA regulation of human, mouse, rat IP6K2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IP6K2 (see all 16):
    hsa-miR-345 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-3673 hsa-miR-206 hsa-miR-892b hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidIP6K2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IP6K2
    Predesigned siRNA for gene silencing in human, mouse, rat IP6K2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IP6K2

    Clone
    Products:
         
    OriGene clones in human, mouse for IP6K2 (see all 38)
    OriGene ORF clones in mouse, rat for IP6K2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): IP6K2 (NM_016291)
    Sino Biological Human cDNA Clone for IP6K2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IP6K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IP6K2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IP6K2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IP6K2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IP6K2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IP6K2_HUMAN, Q9UHH9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0043231intracellular membrane-bounded organelle ----
    GO:0045111intermediate filament cytoskeleton IDA--

    IP6K2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IP6K2 About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (REACTOME)
    Inositol phosphate metabolism0.59
    inositol pyrophosphates biosynthesis0.00
    Synthesis of IPs in the nucleus0.00
    2Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    3Inositol phosphate metabolism (KEGG)
    superpathway of inositol phosphate compounds0.60
    4Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for IP6K2
        inositol pyrophosphates biosynthesis
    superpathway of inositol phosphate compounds


    2 Reactome Pathways for IP6K2
        Interferon alpha/beta signaling
    Synthesis of IPs in the nucleus



    IP6K2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IP6K2
    Interactions:

        GeneGlobe Interaction Network for IP6K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IP6K2 (Q9UHH92, 3 ENSP000003311034) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-67071 I2D: score=5 STRING: ENSP00000345494
    LNX2Q8N4483I2D: score=1 
    IP6K1ENSP000003237804STRING: ENSP00000323780
    IP6K3ENSP000002937564STRING: ENSP00000293756
    IPMKENSP000003630464STRING: ENSP00000363046
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006817phosphate ion transport IEA--
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0030308negative regulation of cell growth IMP11337497
    GO:0043065positive regulation of apoptotic process IMP11337497
    GO:0043647inositol phosphate metabolic process TAS--

    IP6K2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IP6K2

    1 HMDB Compound for IP6K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Diphosinositol pentakisphosphateD-myo-Inositol, 2,3,4,5,6-pentakis(dihydrogen phosphate);1-(trihydrogen diphosphate);Diphospho-myo-inositol pentakisphosphate 148077-18-3--

    1 Novoseek inferred chemical compound relationship for IP6K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phytate 86.8 18 11337497 (2), 11896621 (2), 18195352 (2), 15634191 (2) (see all 7)



    IP6K2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IP6K2 gene (10 alternative transcripts): 
    NM_001005909.2  NM_001005910.2  NM_001005911.2  NM_001146178.2  NM_001146179.2  NM_001190316.1  NM_001190317.1  NM_016291.3  
    NM_001005912.1  NM_001005913.1  

    Unigene Cluster for IP6K2:

    Inositol hexakisphosphate kinase 2
    Hs.595983  [show with all ESTs]
    Unigene Representative Sequence: NM_001190316
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000328631(uc003cuq.3 uc003cup.3) ENST00000479914 ENST00000491686
    ENST00000449563 ENST00000413654 ENST00000443853 ENST00000437427 ENST00000412850
    ENST00000454335 ENST00000340879 ENST00000433104(uc011bbr.2 uc011bbq.2 uc011bbs.2 uc003cut.3 uc003cus.3 uc003cur.3)
    ENST00000416707 ENST00000431721(uc011bbv.2 uc011bbu.2 uc011bbt.2)
    ENST00000449610 ENST00000413298 ENST00000450045 ENST00000446860 ENST00000455545

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IP6K2 (see all 16):
    hsa-miR-345 hsa-miR-4291 hsa-miR-875-3p hsa-miR-548p hsa-miR-3673 hsa-miR-206 hsa-miR-892b hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidIP6K2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IP6K2
    Clone
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    OriGene clones in human, mouse for IP6K2 (see all 38)
    OriGene ORF clones in mouse, rat for IP6K2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): IP6K2 (NM_016291)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IP6K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IP6K2
    Primer
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    OriGene qPCR primer pairs and template standards for IP6K2
    OriGene qSTAR qPCR primer pairs in human, mouse for IP6K2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IP6K2
      QuantiTect SYBR Green Assays in human, mouse, rat IP6K2
      QuantiFast Probe-based Assays in human, mouse, rat IP6K2

    Additional mRNA sequence: 

    AF177145.1 AK024045.1 AK097016.1 AK290526.1 AK291501.1 AK304714.1 AK311013.1 AK315204.1 
    AL117458.1 AL137514.1 AY007091.1 BC004469.2 BC019694.1 BC065533.1 BX537544.1 NR_027437.2 
    NR_027438.2 

    Selected DOTS entries (see all 35):

    DT.212524  DT.100880618  DT.100880624  DT.92454125  DT.100880631  DT.101968381  DT.120924709  DT.100880611 
    DT.120924764  DT.100030570  DT.120924716  DT.100880623  DT.92454113  DT.92045081  DT.40282481  DT.92454126 
    DT.100030569  DT.120924715  DT.100838157  DT.100880621  DT.120924712  DT.95273222  DT.100669378  DT.100686752 

    Selected AceView cDNA sequences (see all 544):

    BQ130569 CR609217 BM665455 BQ011004 BM974998 CB148683 AW157781 CK821902 
    BQ006727 CR595425 AA164332 BQ718517 AL535770 AI220933 AI057549 AI674901 
    CF786019 AF303581 BM558033 BM702302 BU616157 AJ242655 BU070520 BE267263 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IP6K2 (see all 36)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a ·
    SP1:                                -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -   
    SP2:                                -     -     -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                -     -     -     -     -     -     -                       -     -     -           -     -     -     -           -         
    SP4:                                -     -           -     -     -     -                       -     -     -     -     -                                       
    SP5:                                -     -     -     -     -     -     -                       -     -     -     -     -                       -     -         

    ExUns: 10b · 10c · 10d · 10e · 10f · 10g · 10h · 10i · 10j · 10k ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
    SP1:  -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for IP6K2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IP6K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCTGTTGG
    IP6K2 Expression
    About this image


    IP6K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mandibular Condyle
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
    IP6K2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IP6K2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595983
        Custom PCR Arrays for IP6K2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IP6K2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ip6k21 , 5 inositol hexaphosphate kinase 21, 5 92.08(n)1
    96.94(a)1
      9 (59.63 cM)5
    765001  NM_029634.21  NP_083910.21 
     1087959945 
    chicken
    (Gallus gallus)
    Aves IP6K21 inositol hexakisphosphate kinase 2 78.54(n)
    86.08(a)
      416010  NM_001030596.2  NP_001025767.2 
    lizard
    (Anolis carolinensis)
    Reptilia IP6K26
    inositol hexakisphosphate kinase 2
    85(a)
    1 ↔ 1
    2(163961108-163969734)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.92272 Xenopus laevis transcribed sequence with weak similarity more 77(n)    CD254943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059642.12   -- 75.37(n)    BC059642.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100826
    --
    16(a)
    1 → many
    2R(17533682-17545440)
    worm
    (Caenorhabditis elegans)
    Secernentea F30A10.36
    Y22D7AR.66
    (see all 3)
    Protein Y22D7AR.6 (Y22D7AR.6) mRNA, complete cds
    (see all 3)
    32(a)
    31(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    I(9492630-9494589) WBGene00009262
    III(1672517-1676721) WBGene00021260
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KCS16
    Inositol hexakisphosphate (IP6) and inositol hepta...
    11(a)
    1 → many
    IV(479115-482267) YDR017C


    ENSEMBL Gene Tree for IP6K2 (if available)
    TreeFam Gene Tree for IP6K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IP6K2 gene
    IP6K32  IP6K12  IPMK2  
    3 SIMAP similar genes for IP6K2 using alignment to 15 protein entries:     IP6K2_HUMAN (see all proteins):
    IHPK2    IP6K1    IP6K3

    IP6K2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IP6K2 (see all 548)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825641821,2
    --48725344(+) AGCCAA/GGAGAA 2 -- ds50010--------
    rs1166001471,2
    C,F--48725492(+) AGGTAT/CCATCA 2 -- ut311Minor allele frequency- C:0.04WA 118
    rs1870126911,2
    --48725517(+) TTGAAG/TAAATA 2 -- ut310--------
    rs10489401,2
    C,F,H--48725707(-) GGAGTA/C/GAGCTT 6 * S syn1 stop-lost13MN NS EA NA CSA EU 6662
    rs1411355631,2
    F--48725799(+) ACCACG/AGTGTC 4 /T syn11Minor allele frequency- A:0.00NA 4552
    rs2007121991,2
    C--48725867(+) GCTGGC/TGCCGA 4 T A mis11Minor allele frequency- T:0.00EU 1315
    rs1430541851,2
    C,F--48725959(+) GGACCA/GCTTCG 4 A V mis12Minor allele frequency- G:0.00NA EU 5853
    rs1387957131,2
    F--48726096(+) AGGTAC/ACGCCC 4 /R syn11Minor allele frequency- A:0.00NA 4552
    rs1502296361,2
    C,F--48726170(+) CTTGTT/GCATGA 4 /N /H mis12Minor allele frequency- G:0.01NA EU 5875
    rs1419135491,2
    F--48726180(+) AACATG/TAGCTG 4 L syn11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for IP6K2 (48725436 - 48777786 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IP6K2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508918CNV Insertion20534489
    nsv876762CNV Loss21882294
    nsv834685CNV Loss17160897
    nsv818138CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IP6K2
    DNA2.0 Custom Variant and Variant Library Synthesis for IP6K2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606992    OMIM disorders: --

    8 diseases for IP6K2:    
    About MalaCards
    ovarian cancer    labyrinthitis    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    inflammatory bowel disease    retinitis    malaria    cerebritis


    IP6K2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IP6K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 66.3 10 11896621 (3), 15634191 (3), 11337497 (2), 17379600 (1)
    tumors 0 2 11896621 (1), 17379600 (1)


    Export disorders for IP6K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IP6K2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with IP6K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. (PubMed id 10574768)1, 2, 3 Saiardi A....Snyder S.H. (Curr. Biol. 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of a novel inositol hexakisphosphate kinase. (PubMed id 11502751)1, 2 Saiardi A.... Snyder S.H. (J. Biol. Chem. 2001)
    5. Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. (PubMed id 17379600)1, 9 Morrison B.H....Lindner D.J. (J. Biol. Chem. 2007)
    6. Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. (PubMed id 11896621)1, 9 Morrison B.H....Lindner D.J. (Oncogene 2002)
    7. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. (PubMed id 18195352)1, 9 Chakraborty A....Snyder S.H. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. (PubMed id 11337497)1, 9 Morrison B.H....Lindner D.J. (J. Biol. Chem. 2001)
    9. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. (PubMed id 15533939)1, 9 Nagata E....Snyder S.H. (J. Biol. Chem. 2005)
    10. The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase CI' cascade. (PubMed id 23322705)1 Niger C....Stains J.P. (J. Bone Miner. Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51447 HGNC: 17313 AceView: CELSR3 Ensembl:ENSG00000068745 euGenes: HUgn51447
    ECgene: IP6K2 H-InvDB: IP6K2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IP6K2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IP6K2 gene:
    Search GeneIP for patents involving IP6K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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