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Aliases for IP6K1 Gene

Aliases for IP6K1 Gene

  • Inositol Hexakisphosphate Kinase 1 2 3
  • Inositol Hexaphosphate Kinase 1 2 3 4
  • InsP6 Kinase 1 3 4
  • EC 2.7.4.21 4 63
  • IHPK1 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • Pi Uptake Stimulator 3
  • KIAA0263 4
  • PiUS 3

External Ids for IP6K1 Gene

Previous HGNC Symbols for IP6K1 Gene

  • IHPK1

Previous GeneCards Identifiers for IP6K1 Gene

  • GC03M049737
  • GC03M049761
  • GC03M049739

Summaries for IP6K1 Gene

Entrez Gene Summary for IP6K1 Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

GeneCards Summary for IP6K1 Gene

IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K2.

UniProtKB/Swiss-Prot for IP6K1 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Gene Wiki entry for IP6K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K1 Gene

Genomics for IP6K1 Gene

Regulatory Elements for IP6K1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IP6K1 Gene

Chromosome:
3
Start:
49,724,294 bp from pter
End:
49,786,542 bp from pter
Size:
62,249 bases
Orientation:
Minus strand

Genomic View for IP6K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IP6K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K1 Gene

Proteins for IP6K1 Gene

  • Protein details for IP6K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92551-IP6K1_HUMAN
    Recommended name:
    Inositol hexakisphosphate kinase 1
    Protein Accession:
    Q92551
    Secondary Accessions:
    • A8K157
    • A8MUX4
    • Q7L3I7
    • Q96E38

    Protein attributes for IP6K1 Gene

    Size:
    441 amino acids
    Molecular mass:
    50236 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IP6K1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IP6K1 Gene

Proteomics data for IP6K1 Gene at MOPED

Selected DME Specific Peptides for IP6K1 Gene

Post-translational modifications for IP6K1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IP6K1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for IP6K1

Domains & Families for IP6K1 Gene

Protein Domains for IP6K1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IP6K1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92551

UniProtKB/Swiss-Prot:

IP6K1_HUMAN :
  • Belongs to the inositol phosphokinase (IPK) family.
Family:
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K1: view

No data available for Gene Families for IP6K1 Gene

Function for IP6K1 Gene

Molecular function for IP6K1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Enzyme Numbers (IUBMB) for IP6K1 Gene

Gene Ontology (GO) - Molecular Function for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity IEA --
GO:0052723 inositol hexakisphosphate 1-kinase activity IEA --
genes like me logo Genes that share ontologies with IP6K1: view
genes like me logo Genes that share phenotypes with IP6K1: view

Animal Models for IP6K1 Gene

MGI Knock Outs for IP6K1:

Animal Model Products

CRISPR Products

miRNA for IP6K1 Gene

miRTarBase miRNAs that target IP6K1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IP6K1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for IP6K1 Gene

Localization for IP6K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IP6K1 Gene COMPARTMENTS Subcellular localization image for IP6K1 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IP6K1: view

Pathways & Interactions for IP6K1 Gene

genes like me logo Genes that share pathways with IP6K1: view

Gene Ontology (GO) - Biological Process for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046854 phosphatidylinositol phosphorylation IDA 10574768
genes like me logo Genes that share ontologies with IP6K1: view

No data available for SIGNOR curated interactions for IP6K1 Gene

Drugs & Compounds for IP6K1 Gene

(1) Drugs for IP6K1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for IP6K1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Myo-inositol hexakisphosphate
  • 1D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-Myo-inositol hexakisphosphate
  • D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
genes like me logo Genes that share compounds with IP6K1: view

Transcripts for IP6K1 Gene

Unigene Clusters for IP6K1 Gene

Inositol hexakisphosphate kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IP6K1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for IP6K1 Gene

GeneLoc Exon Structure for
IP6K1
ECgene alternative splicing isoforms for
IP6K1

Expression for IP6K1 Gene

mRNA expression in normal human tissues for IP6K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IP6K1 Gene

This gene is overexpressed in Heart (25.0), Testis (10.2), Fetal Brain (8.3), and Fetal testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IP6K1 Gene



SOURCE GeneReport for Unigene cluster for IP6K1 Gene Hs.386168

genes like me logo Genes that share expression patterns with IP6K1: view

Protein tissue co-expression partners for IP6K1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IP6K1 Gene

Orthologs for IP6K1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IP6K1 35
  • 92.14 (n)
  • 96.15 (a)
IP6K1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IP6K1 35
  • 92.37 (n)
  • 96.37 (a)
IP6K1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ip6k1 35
  • 91.61 (n)
  • 96.77 (a)
Ip6k1 16
Ip6k1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IP6K1 35
  • 99.55 (n)
  • 99.77 (a)
IP6K1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ip6k1 35
  • 91.38 (n)
  • 96.54 (a)
oppossum
(Monodelphis domestica)
Mammalia IP6K1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IP6K1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves IP6K1 35
  • 78.21 (n)
  • 83.37 (a)
IP6K1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IP6K1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ip6k1 35
  • 75.45 (n)
  • 79.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15102 35
zebrafish
(Danio rerio)
Actinopterygii ip6k1 35
  • 70.85 (n)
  • 74.19 (a)
ip6k1 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10082 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F30A10.3 35
  • 47.35 (n)
  • 43.95 (a)
F30A10.3 36
  • 35 (a)
ManyToMany
T20F7.3 36
  • 26 (a)
ManyToMany
Y22D7AR.6 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 36
  • 11 (a)
OneToMany
ARG82 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for IP6K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IP6K1 Gene

ENSEMBL:
Gene Tree for IP6K1 (if available)
TreeFam:
Gene Tree for IP6K1 (if available)

Paralogs for IP6K1 Gene

Paralogs for IP6K1 Gene

(3) SIMAP similar genes for IP6K1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IP6K1: view

Variants for IP6K1 Gene

Sequence variations from dbSNP and Humsavar for IP6K1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1128315 -- 49,775,017(-) aataa(G/T)gtgtt intron-variant
rs2307021 -- 49,728,050(-) GGGTT(C/G)TGCTC intron-variant
rs3206653 -- 49,734,510(-) TGTGC(A/G)ACTTA intron-variant
rs3749237 -- 49,732,599(-) AAGGC(C/T)GAAGC intron-variant
rs3749238 -- 49,726,244(-) TCCCA(C/G)GGCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IP6K1 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
esv2544793 CNV Insertion 19546169
esv1442016 CNV Insertion 17803354
nsv834688 CNV Loss 17160897
dgv116n6 CNV Loss 16902084
nsv876766 CNV Loss 21882294

Variation tolerance for IP6K1 Gene

Residual Variation Intolerance Score: 24.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IP6K1 Gene

HapMap Linkage Disequilibrium report
IP6K1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K1 Gene

Disorders for IP6K1 Gene

Relevant External Links for IP6K1

Genetic Association Database (GAD)
IP6K1
Human Genome Epidemiology (HuGE) Navigator
IP6K1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IP6K1
genes like me logo Genes that share disorders with IP6K1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K1 Gene

Publications for IP6K1 Gene

  1. The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. (PMID: 15221640) Kamimura J. … Matsumoto N. (J. Hum. Genet. 2004) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio. (PMID: 24865181) Wundenberg T. … Mayr G.W. (Biochem. J. 2014) 67
  4. Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. (PMID: 25349427) Rao F. … Snyder S.H. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. (PMID: 25082827) JuliA A. … Marsal S. (Hum. Mol. Genet. 2014) 67

Products for IP6K1 Gene

Sources for IP6K1 Gene

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