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Aliases for IP6K1 Gene

Aliases for IP6K1 Gene

  • Inositol Hexakisphosphate Kinase 1 2 3 5
  • Inositol Hexaphosphate Kinase 1 2 3 4
  • InsP6 Kinase 1 3 4
  • EC 4 61
  • IHPK1 3 4
  • ATP:1D-Myo-Inositol-Hexakisphosphate Phosphotransferase 3
  • Pi Uptake Stimulator 3
  • KIAA0263 4
  • PiUS 3

External Ids for IP6K1 Gene

Previous HGNC Symbols for IP6K1 Gene

  • IHPK1

Previous GeneCards Identifiers for IP6K1 Gene

  • GC03M049737
  • GC03M049761
  • GC03M049739
  • GC03M049743
  • GC03M049747
  • GC03M049752
  • GC03M049759

Summaries for IP6K1 Gene

Entrez Gene Summary for IP6K1 Gene

  • This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

GeneCards Summary for IP6K1 Gene

IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include inositol-1,4,5-trisphosphate 3-kinase activity and inositol hexakisphosphate 1-kinase activity. An important paralog of this gene is IP6K3.

UniProtKB/Swiss-Prot for IP6K1 Gene

  • Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Gene Wiki entry for IP6K1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IP6K1 Gene

Genomics for IP6K1 Gene

Regulatory Elements for IP6K1 Gene

Enhancers for IP6K1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049867 0.7 ENCODE 27.9 -81.4 -81431 0.2 SAP130 MIER1 ZNF133 ARID4B NCOA1 MIER2 REST ZSCAN9 RARA HDAC2 IP6K1 ENSG00000230698 ENSG00000228008 MST1R ENSG00000223343 PHF5EP NICN1 RN7SL217P CAMKV
GH03G049869 0.7 ENCODE 27.9 -81.7 -81681 0.2 SAP130 MIER1 NFRKB ZNF133 ZNF223 ARID4B NCOA1 REST ZSCAN9 SMARCA4 IP6K1 ENSG00000230698 MST1R ENSG00000228008 ENSG00000223343 PHF5EP NICN1 RN7SL217P CAMKV
GH03G050234 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -458.7 -458714 21.3 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D HYAL3 GNAI2 HYAL1 CYB561D2 SEMA3B-AS1 SEMA3B LSMEM2 NAT6 IFRD2 SEMA3F-AS1
GH03G049164 1.1 ENCODE 16.6 +620.5 620508 2.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 WDR6 QRICH1 ZNF589 NME6 IP6K1 MRPS18AP1 SEMA3F-AS1 RHOA-IT1 CCDC71 ENSG00000223343
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IP6K1 on UCSC Golden Path with GeneCards custom track

Promoters for IP6K1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152267 342 1601 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for IP6K1 Gene

49,724,294 bp from pter
49,786,542 bp from pter
62,249 bases
Minus strand

Genomic View for IP6K1 Gene

Genes around IP6K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IP6K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IP6K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IP6K1 Gene

Proteins for IP6K1 Gene

  • Protein details for IP6K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol hexakisphosphate kinase 1
    Protein Accession:
    Secondary Accessions:
    • A8K157
    • A8MUX4
    • Q7L3I7
    • Q96E38

    Protein attributes for IP6K1 Gene

    441 amino acids
    Molecular mass:
    50236 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA13393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IP6K1 Gene


neXtProt entry for IP6K1 Gene

Selected DME Specific Peptides for IP6K1 Gene


Post-translational modifications for IP6K1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IP6K1 Gene

Antibody Products

  • Abcam antibodies for IP6K1
  • Cloud-Clone Corp. Antibodies for IP6K1

Domains & Families for IP6K1 Gene

Protein Domains for IP6K1 Gene


Suggested Antigen Peptide Sequences for IP6K1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol phosphokinase (IPK) family.
  • Belongs to the inositol phosphokinase (IPK) family.
genes like me logo Genes that share domains with IP6K1: view

No data available for Gene Families for IP6K1 Gene

Function for IP6K1 Gene

Molecular function for IP6K1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
UniProtKB/Swiss-Prot Function:
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.

Enzyme Numbers (IUBMB) for IP6K1 Gene

Gene Ontology (GO) - Molecular Function for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity TAS --
GO:0000828 inositol hexakisphosphate kinase activity TAS --
GO:0000829 inositol heptakisphosphate kinase activity TAS --
GO:0000832 inositol hexakisphosphate 5-kinase activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IP6K1: view
genes like me logo Genes that share phenotypes with IP6K1: view

Animal Models for IP6K1 Gene

MGI Knock Outs for IP6K1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IP6K1

CRISPR Products

miRNA for IP6K1 Gene

miRTarBase miRNAs that target IP6K1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IP6K1 Gene

Localization for IP6K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IP6K1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IP6K1 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IP6K1: view

Pathways & Interactions for IP6K1 Gene

genes like me logo Genes that share pathways with IP6K1: view

Gene Ontology (GO) - Biological Process for IP6K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0046854 phosphatidylinositol phosphorylation IDA 10574768
genes like me logo Genes that share ontologies with IP6K1: view

No data available for SIGNOR curated interactions for IP6K1 Gene

Drugs & Compounds for IP6K1 Gene

(1) Drugs for IP6K1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for IP6K1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Myo-inositol hexakisphosphate
  • 1D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-Myo-inositol hexakisphosphate
  • D-Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • Myo-Inositol 1,2,3,4,5,6-hexakisphosphate
genes like me logo Genes that share compounds with IP6K1: view

Transcripts for IP6K1 Gene

Unigene Clusters for IP6K1 Gene

Inositol hexakisphosphate kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IP6K1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: -

Relevant External Links for IP6K1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IP6K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IP6K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IP6K1 Gene

This gene is overexpressed in Heart (25.0), Testis (10.2), Fetal Brain (8.3), and Fetal testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IP6K1 Gene

Protein tissue co-expression partners for IP6K1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IP6K1 Gene:


SOURCE GeneReport for Unigene cluster for IP6K1 Gene:


Evidence on tissue expression from TISSUES for IP6K1 Gene

  • Nervous system(4.9)
  • Bone marrow(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with IP6K1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IP6K1 Gene

Orthologs for IP6K1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IP6K1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IP6K1 34 35
  • 99.55 (n)
(Canis familiaris)
Mammalia IP6K1 34 35
  • 92.37 (n)
(Bos Taurus)
Mammalia IP6K1 34 35
  • 92.14 (n)
(Mus musculus)
Mammalia Ip6k1 34 16 35
  • 91.61 (n)
(Rattus norvegicus)
Mammalia Ip6k1 34
  • 91.38 (n)
(Ornithorhynchus anatinus)
Mammalia IP6K1 35
  • 85 (a)
(Monodelphis domestica)
Mammalia IP6K1 35
  • 76 (a)
(Gallus gallus)
Aves IP6K1 34 35
  • 78.21 (n)
(Anolis carolinensis)
Reptilia IP6K1 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ip6k1 34
  • 75.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15102 34
(Danio rerio)
Actinopterygii ip6k1 34 35
  • 70.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10082 35
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F30A10.3 34 35
  • 47.35 (n)
Y22D7AR.6 35
  • 30 (a)
T20F7.3 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCS1 35
  • 11 (a)
ARG82 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
-- 35
  • 30 (a)
Species where no ortholog for IP6K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IP6K1 Gene

Gene Tree for IP6K1 (if available)
Gene Tree for IP6K1 (if available)

Paralogs for IP6K1 Gene

Paralogs for IP6K1 Gene

(3) SIMAP similar genes for IP6K1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IP6K1: view

Variants for IP6K1 Gene

Sequence variations from dbSNP and Humsavar for IP6K1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000024504 -- 49,726,919(+) GAGGA(A/G)CCTGG utr-variant-3-prime
rs1000074637 -- 49,754,396(+) AAGAT(C/G)AATCA intron-variant
rs1000078248 -- 49,774,315(+) AGGCA(A/G)GAGAA intron-variant
rs1000237234 -- 49,754,671(+) CCTTG(A/G)CAGGG intron-variant
rs1000264222 -- 49,748,150(+) TTCTA(C/T)TCAGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IP6K1 Gene

Variant ID Type Subtype PubMed ID
dgv116n6 CNV deletion 16902084
esv1442016 CNV insertion 17803354
esv2544793 CNV insertion 19546169
nsv1139114 CNV deletion 24896259
nsv508217 CNV deletion 20534489
nsv834688 CNV loss 17160897
nsv965165 CNV duplication 23825009

Variation tolerance for IP6K1 Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IP6K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IP6K1 Gene

Disorders for IP6K1 Gene

Relevant External Links for IP6K1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IP6K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IP6K1 Gene

Publications for IP6K1 Gene

  1. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. (PMID: 15221640) Kamimura J. … Matsumoto N. (J. Hum. Genet. 2004) 3 22 64
  4. Identification and characterization of a novel inositol hexakisphosphate kinase. (PMID: 11502751) Saiardi A. … Snyder S.H. (J. Biol. Chem. 2001) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64

Products for IP6K1 Gene

Sources for IP6K1 Gene

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