INVS Gene
protein-coding GIFtS: 55
GCID: GC09P102861
|
|
inversin(Previous name: nephronophthisis 2 (infantile) )
(Previous symbol: NPHP2)
| |
Aliases
for INVS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inversin1 | | Nephronophthisis 2 (Infantile)1 | | NPHP21 2 3 5 | | Inversion Of Embryonic Turning2 | | INV2 3 5 | | Nephrocystin-23 | | Inversion Of Embryo Turning Homolog2 3 | | Nephrocystin-23 | | NPH22 5 | | |
Export aliases for INVS gene to outside databasesPrevious GC identifers: GC09P093661 GC09P094605 GC09P096318 GC09P098241 GC09P099941 GC09P101901 GC09P072460 |
Summaries
for INVS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for INVS:
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encodedprotein may function in renal tubular development and function, and in left-right axis determination. This proteininteracts with nephrocystin and infers a connection between primary cilia function and left-right axis determination.A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisistype 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. (provided byRefSeq, May 2012)
UniProtKB/Swiss-Prot: INVS_HUMAN, Q9Y283Function: Required for normal renal development and establishment of left-right axis. Probably acts as a molecularswitch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmicdisheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal developmentto oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in theorganization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Doesnot seem to be strictly required for ciliogenesis (By similarity)
Gene Wiki entry for INVS
|
Genomic Views
for INVS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INVS gene promoter:
AP-1 ATF-2 c-Jun NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for INVS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INVS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31INVS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P102861: view genomic region
(about GC identifiers)
Start:
|
102,861,511 bp from pter |
End:
|
103,063,426 bp from pter |
Size:
|
201,916 bases |
Orientation:
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plus strand |
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Proteins
for INVS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INVS_HUMAN, Q9Y283 (See
protein sequence)Recommended Name: Inversin Size: 1065 amino acids; 117826 Da
Subunit: Binds calmodulin via its IQ domains. Interacts with APC2. Interacts with alpha-, beta-, and gamma-catenin.Interacts with N-cadherin (CDH2). Interacts with microtubules (By similarity). Interacts with NPHP1. Interacts withDVL1, PRICKLE (PRICKLE1 or PRICKLE2) and Strabismus (VANGL1 or VANGL2). Interacts with NPHP3. Interacts with IQCB1;the interaction likely requires additional interactors
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton,spindle (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity). Cellprojection, cilium. Note=Associates with several components of the cytoskeleton including ciliary, random andpolarized microtubules. During mitosis, it is recruited to mitotic spindle. Frequently membrane-associated, membranelocalization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted afterincubation of the cell monolayer with low-calcium/EGTA medium
Sequence caution: Sequence=AAD02131.2; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH41665.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: A2A2Y2 Q5W0T6 Q8IVX8 Q9BRB9 Q9Y488 Q9Y498Alternative splicing: 3 isoforms: Q9Y283-1 Q9Y283-2 Q9Y283-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for INVS: NX_Q9Y283
Post-translational modifications:
May be ubiquitinated via its interaction with APC2 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y283
INVS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_055240.2 NP_899068.1
ENSEMBL proteins: ENSP00000262457 ENSP00000262456 ENSP00000364056 ENSP00000444454
Human Recombinant Protein Products for INVS:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
INVS for ontologies About GeneDecksing
INVS Antibody Products:
Assay Products for INVS: |
Protein
Domains /
Families
for INVS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INVS for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y283ProtoNet protein and cluster: Q9Y283 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: INVS_HUMAN, Q9Y283Domain: The D-box 1 (destruction box 1) mediates the interaction with APC2, and may act as a recognition signal fordegradation via the ubiquitin-proteasome pathway (By similarity)Similarity: Contains 16 ANK repeatsSimilarity: Contains 2 IQ domains |
Function
for INVS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: INVS_HUMAN, Q9Y283Function: Required for normal renal development and establishment of left-right axis. Probably acts as a molecularswitch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmicdisheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal developmentto oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in theorganization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Doesnot seem to be strictly required for ciliogenesis (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0005516 | calmodulin binding |
IEA | -- |
INVS for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for INVS:
12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Invs):
INVS for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INVS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INVS (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): INVS (NM_183245) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INVS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INVS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INVS |
|
Pathways & Interactions
for INVS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for INVS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/18 Interacting proteins for INVS (Q9Y2832, 3 ENSP000002624574) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
INVS for ontologies About GeneDecksing
|
Drugs & Compounds
for INVS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
INVS for compounds About GeneDecksing
 Browse Tocris compounds for INVS
1 HMDB Compound for INVS About this table
2 Novoseek chemical compound relationships for INVS gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sucrose |
10.4 |
2 |
10552519 (1) |
| iron |
0 |
2 |
1385257 (1) |
Search CenterWatch for drugs/clinical trials and news about INVS
|
Transcripts
for INVS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INVS gene (2 alternative transcripts): NM_014425.3 NM_183245.2 Unigene Cluster for INVS: Inversin Hs.558477 [show with all ESTs]Unigene Representative Sequence: BC0638478 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262457(uc010mta.2 uc004bao.1 uc004bap.1 uc004baq.1 uc004bar.1 uc010mtb.1)
ENST00000496467 ENST00000480309 ENST00000262456 ENST00000374921 ENST00000466647
ENST00000460636 ENST00000541287(uc011lve.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INVS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INVS (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): INVS (NM_183245) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INVS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INVS |
Additional cDNA sequence: AF039217.2 AF084367.1 AK304851.1 AK312795.1 BC006370.2 BC041665.1 BC056897.1 BC063847.1 BC072429.1 BC111761.1 BC112351.1 NR_051962.1 13 DOTS entries: DT.91689918 DT.210912 DT.75170510 DT.100019250 DT.100751517 DT.115451 DT.100032095 DT.307421 DT.121159833 DT.121159866 DT.100838042 DT.121159881 DT.449369 24/73 AceView cDNA sequences (see all 73): AI652253 AA411470 AI675617 AA890523 BC006370 BQ020921 AI142391 AI653316 CR610694 CA312616 BC072429 CB141673 BM681782 NM_014425 BM468699 AI538178 AI421758 NM_183245 BP365911 BC041665 AF084367 AA580524 BF733033 BX104595
GeneLoc Exon Structure
|
Expression
for INVS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INVS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See INVS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INVS
SOURCE GeneReport for Unigene cluster: Hs.558477
UniProtKB/Swiss-Prot: INVS_HUMAN, Q9Y283Tissue specificity: Widely expressed. Strongly expressed in the primary cilia of renal tubular cells
SABiosciences Expression via Pathway-Focused PCR Array including INVS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INVS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INVS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INVS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INVS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INVS |
Orthologs
for INVS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for INVS gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
INVS1 |
inversin |
67.98(n)
67.8(a) |
|
395234 NM_204551.1 NP_989882.1 |
lizard
(Anolis carolinensis) |
Reptilia |
INVS6 |
-- |
62(a) |
1 ↔ 1 |
6(55027638-55101256) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3987172 |
inv2 |
73.16(n) |
|
AF321229.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
invs2 |
inversin |
75.13(n) |
|
245946 AF465261.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG425346 |
-- |
7(a) |
1 ↔ 1 |
3R(23166344-23198296) |
worm
(Caenorhabditis elegans) |
Secernentea |
T28D6.43
mlt-41 |
Ank repeat (8 domains)3
Protein MLT-41 |
29(a)
(best of 2)3
43.45(n)1
32.45(a)1 |
|
III(11432134-11437680)3
1803291 NM_075511.41 NP_507912.21 |
ENSEMBL Gene Tree for INVS (if available)
TreeFam Gene Tree for INVS (if available) |
Paralogs
for INVS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for INVS gene
- TANC22 TNKS22 ANKRD172 ANK32 ANKHD12 ANK12 ANKRD522 ANKHD1-EIF4EBP32
- TNKS2 TANC12 ANKRD502 ANKRD282 ANK22 ANKRD442
18/20 SIMAP similar genes for INVS using alignment to 4 protein entries: INVS_HUMAN (see all proteins)
(see all similar genes):HACE1 ANKRD44 RAI14 ANKRD6 ANKRD46 ANKRD55
FANK1 ANKRD54 OSBPL1A PSMD10 ANK2 CDKN2C
PPP1R12B ANK3 ANKRD42 DKFZp761E1322 GABPB1 MTPN
INVS for paralogs About GeneDecksing
|
Genomic Variants
for INVS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INVS (102861511 - 103063426 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INVS: --
Human Gene Mutation Database (HGMD): INVS
Locus Specific Mutation Databases (LSDB): INVS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INVS |
|
Disorders
/ Diseases
for INVS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
INVS for disorders About GeneDecksing
OMIM gene information: 243305
OMIM disorders: 602088
UniProtKB/Swiss-Prot: INVS_HUMAN, Q9Y283
Defects in INVS are the cause of nephronophthisis type 2 (NPHP2) [MIM:602088]; also known as infantilenephronophthisis. NPHP2 is an autosomal recessive disorder resulting in end-stage renal disease. It is characterizedby early onset and rapid progression. Phenotypic manifestations include enlarged kidneys, chronic tubulo-interstitialnephritis, anemia, hyperkalemic metabolic acidosis. Some patients also display situs inversus. Pathologically, itdiffers from later-onset nephronophthisis by the absence of medullary cysts and thickened tubular basement membranesand by the presence of cortical microcysts
20/24  diseases for INVS (see all 24): About MalaCardsnephronophthisis nephronophthisis 2, infantile nephronophthisis 2 bardet-biedl syndrome
senior-loken syndrome situs inversus asphyxiating thoracic dystrophy west nile encephalitis
renal-hepatic-pancreatic dysplasia polycystic kidney disease joubert syndrome and related disorders joubert syndrome
retinitis pigmentosa interstitial nephritis kidney disease cystic kidney
biliary atresia was-related disorders dextrocardia nephritis
5 diseases from the University of Copenhagen DISEASES database for INVS:Nephronophthisis Situs inversus Cystic kidney Asphyxiating thoracic dystrophy
Polycystic kidney disease 9 Novoseek disease relationships for INVS gene About this table
Genetic Association Database (GAD): INVS
Human Genome Epidemiology (HuGE) Navigator: INVS (1 document)
Export disorders for INVS gene to outside databases
|
Publications
for INVS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INVS gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with INVS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. (PubMed id 12872123)1, 2, 3, 4, 9 Otto E.A.... Hildebrandt F. (2003)
- Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic- pancreatic dysplasia. (PubMed id 18371931)1, 2, 9 Bergmann C.... Omran H. (2008)
- Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. (PubMed id 15852005)1, 2 Simons M.... Walz G. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin. (PubMed id 11941489)1, 2 Morgan D.... Strachan T. (2002)
- Association of INVS (NPHP2) mutation in an adolescent exhibiting nephronophthisis (NPH) and complete situs inversus. (PubMed id 18218308)1, 9 Okada M....Takemura T. (2008)
- Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells. (PubMed id 12221118)1, 9 Nurnberger J....Phillips C.L. (2002)
- Mutations of NPHP2 and NPHP3 in infantile nephronophthisis. (PubMed id 19177160)1, 9 Tory K....Salomon R. (2009)
- Analysis of multiple Invs transcripts in mouse and MDCK cells. (PubMed id 15533716)1, 9 Ward H.H....Phillips C. (2004)
|
External Searches for INVS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing INVS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing INVS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing INVS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INVS | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/INVS |
|
| | |
About This Section
| Patent Information for INVS gene:
Search GeneIP for patents involving INVS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INVS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INVS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INVS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INVS | | | OriGene Protein Over-expression Lysate for INVS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INVS | | OriGene 3'-UTR Clone for INVS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INVS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INVS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for INVS | | OriGene Custom Protein Services for INVS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INVS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INVS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INVS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INVS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INVS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INVS |
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| | | | Search Tocris compounds for INVS |
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 | | | INVS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INVS |
|  |  |  |  | | | | Search ThermoFisher Antibodies for INVS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INVS |
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