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INTU Gene

protein-coding   GIFtS: 47
GCID: GC04P128554

Inturned Planar Cell Polarity Protein

(Previous names: PDZ domain containing 6, inturned planar cell polarity effector...)
(Previous symbols: PDZK6, PDZD6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inturned Planar Cell Polarity Protein1 2     KIAA12843 5
PDZK61 2 3 5     Inturned Planar Cell Polarity Effector Homolog (Drosophila)1
PDZD61 2 3     INT2
PDZ Domain Containing 61 2     Homolog Of Inturned2
Inturned Planar Cell Polarity Effector Homolog2 3     Protein Inturned2
PDZ Domain-Containing Protein 62 3     

External Ids:    HGNC: 292391   Entrez Gene: 271522   Ensembl: ENSG000001640667   OMIM: 6106215   UniProtKB: Q9ULD63   

Export aliases for INTU gene to outside databases

Previous GC identifers: GC04P128774 GC04P124281


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for INTU Gene:
INTU (inturned planar cell polarity protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6
Function: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling
the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell
surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key
role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an
indirect effect on hedgehog signaling (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTU gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   FOXC1   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTU promoter sequence
   Search Chromatin IP Primers for INTU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q28.2

INTU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTU gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P128554:  view genomic region     (about GC identifiers)

Start:
128,544,426 bp from pter      End:
128,647,892 bp from pter
Size:
103,467 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6 (See protein sequence)
Recommended Name: Protein inturned  
Size: 942 amino acids; 105648 Da
Sequence caution: Sequence=BAA86598.1; Type=Erroneous initiation;
Secondary accessions: A1L4N5 D6RAE6 D6RBT4 Q4W5I8 Q86V55
Alternative splicing: 4 isoforms:  Q9ULD6-1   Q9ULD6-2   Q9ULD6-3   Q9ULD6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTU: NX_Q9ULD6

Explore proteomics data for INTU at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See INTU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056508.2  
    ENSEMBL proteins: 
     ENSP00000422550   ENSP00000334003   ENSP00000426287   ENSP00000421995   ENSP00000426171  
     ENSP00000427150   ENSP00000296461  

    INTU Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for INTU
    OriGene Protein Over-expression Lysate for INTU
    OriGene MassSpec for INTU
    OriGene Custom Protein Services for INTU
    GenScript Custom Purified and Recombinant Proteins Services for INTU
    Novus Biologicals INTU Protein
    Novus Biologicals INTU Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTU

     
    Search eBioscience for Proteins for INTU 

     
    antibodies-online proteins for INTU (2 products) 

     
    antibodies-online peptides for INTU

    INTU Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals INTU Antibodies
    Search for Antibodies for INTU at Abcam
    Cloud-Clone Corp. Antibodies for INTU
    ThermoFisher Antibody for INTU
    antibodies-online antibodies for INTU (4 products) 

    INTU Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for INTU
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INTU
    Cloud-Clone Corp. CLIAs for INTU
    Search eBioscience for ELISAs for INTU 
    antibodies-online kits for INTU (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9ULD6

    ProtoNet protein and cluster: Q9ULD6

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6
    Similarity: Belongs to the inturned family
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with INTU           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INTU_HUMAN, Q9ULD6
    Function: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling
    the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell
    surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key
    role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an
    indirect effect on hedgehog signaling (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with INTU           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for INTU:
     Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Intu):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  normal  vision/eye 

    Find genes that share phenotypes with INTU           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Intutm1.2Aliu for INTU

       genOway: Develop your customized and physiologically relevant rodent model for INTU

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat INTU using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate INTU:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-26a hsa-miR-23c hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidINTU 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for INTU
    Predesigned siRNA for gene silencing in human, mouse, rat INTU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INTU

    Clone
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    OriGene clones in human, mouse for INTU (see all 6)
    OriGene ORF clones in mouse, rat for INTU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTU (NM_015693)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for INTU
    Browse ESI BIO Cell Lines and PureStem Progenitors for INTU 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INTU_HUMAN, Q9ULD6: Cytoplasm (By similarity). Cell surface (By similarity). Note=Enriched at the apical surface
    in ciliated cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0009986cell surface IEA--

    Find genes that share ontologies with INTU           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including INTU: 
              Primary Cilia in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for INTU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for INTU (Q9ULD63 ENSP000003340034) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    VANGL1Q8TAA93, ENSP000003108004I2D: score=1 STRING: ENSP00000310800
    CELSR1Q9NYQ63, ENSP000002627384I2D: score=1 STRING: ENSP00000262738
    DVL2O146413, ENSP000000053404I2D: score=1 STRING: ENSP00000005340
    NCAM2O153943, ENSP000003833924I2D: score=1 STRING: ENSP00000383392
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ISS--
    GO:0008589regulation of smoothened signaling pathway ISS--
    GO:0021513spinal cord dorsal/ventral patterning IEA--
    GO:0042384cilium assembly ISS--
    GO:0060173limb development ISS--

    Find genes that share ontologies with INTU           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTU



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTU gene: 
    NM_015693.3  

    Unigene Cluster for INTU:

    Inturned planar cell polarity protein
    Hs.391481  [show with all ESTs]
    Unigene Representative Sequence: NM_015693
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504491 ENST00000335251 ENST00000503626(uc003ifk.2 uc011cgq.2)
    ENST00000503952 ENST00000504276 ENST00000506283 ENST00000512995 ENST00000510766
    ENST00000296461
    miRNA
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    Block miRNA regulation of human, mouse, rat INTU using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate INTU:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-26a hsa-miR-23c hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidINTU 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for INTU
    Predesigned siRNA for gene silencing in human, mouse, rat INTU
    Clone
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    OriGene clones in human, mouse for INTU (see all 6)
    OriGene ORF clones in mouse, rat for INTU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTU (NM_015693)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INTU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTU
      QuantiTect SYBR Green Assays in human, mouse, rat INTU
      QuantiFast Probe-based Assays in human, mouse, rat INTU

    Additional mRNA sequence: 

    AB033110.1 AK123320.1 AK291481.1 BC130611.1 BC144182.1 HQ234310.1 HQ234311.1 

    4 DOTS entries:

    DT.100746673  DT.310607  DT.121237246  DT.40204235 

    Selected AceView cDNA sequences (see all 32):

    AB033110 AI803781 AI564210 AK123320 NM_015693 AI056201 CA414645 AI016810 
    BC051698 AW263249 Z42218 CD252477 BX106427 AI811942 W24911 AA460936 
    AW150229 Z38466 C00590 AI696253 BX497550 BQ949910 BV202916 CF597130 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGATCAAA
    INTU Expression
    About this image


    INTU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    INTU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.391481
        Pathway & Disease-focused RT2 Profiler PCR Array including INTU: 
              Primary Cilia in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat INTU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for INTU gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Intu1 , 5 inturned planar cell polarity effector homolog (Drosophila)1, 5 79.39(n)1
    79.21(a)1
      3 (19.46 cM)5
    3806141  NM_175515.51  NP_780724.31 
     405312865 
    chicken
    (Gallus gallus)
    Aves INTU1 inturned planar cell polarity effector homolog (Drosophila) 70.92(n)
    67.01(a)
      422494  XM_420459.4  XP_420459.3 
    lizard
    (Anolis carolinensis)
    Reptilia INTU6
    inturned planar cell polarity protein
    60(a)
    1 ↔ 1
    5(136476539-136512370)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.44232 Transcribed sequences 73.29(n)    142014701 
    zebrafish
    (Danio rerio)
    Actinopterygii intu1 inturned planar cell polarity effector homolog (Drosophila) 58.04(n)
    57.31(a)
      100007575  XM_001345962.5  XP_001345998.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta in1 inturned 40.97(n)
    29.37(a)
      40246  NM_176370.3  NP_788548.1 


    ENSEMBL Gene Tree for INTU (if available)
    TreeFam Gene Tree for INTU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTU (see all 1469)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23911881,2
    C,F,H--128552116(+) ACACCC/TTCCCT 1 -- us2k124Minor allele frequency- T:0.44NS EA NA WA CSA 2349
    rs23911891,2
    C,F,A--128552201(+) TAAAAT/AAACTT 1 -- us2k1 tfbs37Minor allele frequency- A:0.28NA WA EA 366
    rs1507252731,2
    --128552375(+) GGTCTA/GTCTGC 1 -- us2k10--------
    rs1390762611,2
    C--128552500(+) GCTGAA/GTCACA 1 -- us2k10--------
    rs1915833511,2
    --128552538(+) CCAGGA/CCCCTC 1 -- us2k10--------
    rs1841568401,2
    --128552635(+) TTTAGA/GTAAGT 1 -- us2k10--------
    rs1494868221,2
    --128552750(+) CATACC/TGGCCA 1 -- us2k10--------
    rs1459858791,2
    --128552998(+) TTACAC/TGCTGC 1 -- us2k10--------
    rs1399176571,2
    --128553077(+) TATATA/GTATTT 1 -- us2k10--------
    rs1886847241,2
    --128553132(+) TTCACA/TTTTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INTU (128544426 - 128647892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for INTU (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728289CNV Deletion23290073
    esv2728290CNV Deletion23290073
    nsv879923CNV Loss21882294
    nsv830057CNV Loss17160897
    nsv879916CNV Loss21882294
    dgv5712n71CNV Loss21882294
    dgv5711n71CNV Loss21882294
    nsv830056CNV Loss17160897
    nsv879925CNV Loss21882294
    nsv879924CNV Loss21882294

    Human Gene Mutation Database (HGMD): INTU
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTU
    DNA2.0 Custom Variant and Variant Library Synthesis for INTU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610621    OMIM disorders: --


    Find genes that share disorders with INTU           About GenesLikeMe


    Export disorders for INTU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTU gene integrated from 10 sources:
    (articles sorted by number of sources associating them with INTU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. (PubMed id 21761479)1, 3 Heydeck W. and Liu A. (Dev. Dyn. 2011)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. (PubMed id 21948523)1 Al-Balool H.H....Jackson M.S. (Genome Res. 2011)
    7. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. (PubMed id 16493421)1 Park T.J....Wallingford J.B. (Nat. Genet. 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27152 HGNC: 29239 AceView: PDZK6 Ensembl:ENSG00000164066 euGenes: HUgn27152
    ECgene: INTU H-InvDB: INTU

    (According to HUGE)
    About This Section

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    HUGE: KIAA1284

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INTU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INTU gene:
    Search GeneIP for patents involving INTU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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