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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

INTU Gene

protein-coding   GIFtS: 46
GCID: GC04P128554

Inturned Planar Cell Polarity Protein

(Previous names: PDZ domain containing 6, inturned planar cell polarity effector...)
(Previous symbols: PDZK6, PDZD6)
  Search for INTU
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inturned Planar Cell Polarity Protein1 2     KIAA12843 5
PDZK61 2 3 5     Inturned Planar Cell Polarity Effector Homolog (Drosophila)1
PDZD61 2 3     INT2
PDZ Domain Containing 61 2     Homolog Of Inturned2
Inturned Planar Cell Polarity Effector Homolog2 3     Protein Inturned2
PDZ Domain-Containing Protein 62 3     

External Ids:    HGNC: 292391   Entrez Gene: 271522   Ensembl: ENSG000001640667   OMIM: 6106215   UniProtKB: Q9ULD63   

Export aliases for INTU gene to outside databases

Previous GC identifers: GC04P128774 GC04P124281


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for INTU Gene: 
INTU (inturned planar cell polarity protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6
Function: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling
the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell
surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key
role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an
indirect effect on hedgehog signaling (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the INTU gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   FOXC1   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTU promoter sequence
   Search SABiosciences Chromatin IP Primers for INTU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q28.2

INTU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTU gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P128554:  view genomic region     (about GC identifiers)

Start:
128,544,426 bp from pter      End:
128,637,934 bp from pter
Size:
93,509 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6 (See protein sequence)
Recommended Name: Protein inturned  
Size: 942 amino acids; 105648 Da
Subcellular location: Cytoplasm (By similarity). Cell surface (By similarity). Note=Enriched at the apical surface
in ciliated cells (By similarity)
Sequence caution: Sequence=BAA86598.1; Type=Erroneous initiation;
Secondary accessions: A1L4N5 D6RAE6 D6RBT4 Q4W5I8 Q86V55
Alternative splicing: 4 isoforms:  Q9ULD6-1   Q9ULD6-2   Q9ULD6-3   Q9ULD6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTU: NX_Q9ULD6

Explore proteomics data for INTU at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULD6

  • INTU Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    INTU Protein Expression
    REFSEQ proteins: NP_056508.2  
    ENSEMBL proteins: 
     ENSP00000422550   ENSP00000334003   ENSP00000426287   ENSP00000421995   ENSP00000426171  
     ENSP00000427150   ENSP00000296461  

    Human Recombinant Protein Products for INTU: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for INTU
    OriGene Protein Over-expression Lysate for INTU
    OriGene MassSpec for INTU 
    OriGene Custom Protein Services for INTU
    GenScript Custom Purified and Recombinant Proteins Services for INTU
    Novus Biologicals INTU Protein
    Novus Biologicals INTU Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for INTU 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0009986cell surface IEA--

    INTU for ontologies           About GeneDecksing



    INTU Antibody Products: 
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    Novus Biologicals INTU Antibodies
    Abcam antibodies for INTU
    Cloud-Clone Corp. Antibodies for INTU 
    ThermoFisher Antibody for INTU
    LSBio Antibodies in human, mouse, rat for INTU 

    Assay Products for INTU: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INTU
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for INTU 
    Cloud-Clone Corp. CLIAs for INTU


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9ULD6

    ProtoNet protein and cluster: Q9ULD6

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6
    Similarity: Belongs to the inturned family
    Similarity: Contains 1 PDZ (DHR) domain


    INTU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INTU_HUMAN, Q9ULD6
    Function: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling
    the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell
    surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key
    role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an
    indirect effect on hedgehog signaling (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    INTU for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for INTU:
     Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Intu):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system  normal  vision/eye 

    INTU for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Intutm1.2Aliu for INTU

       inGenious Targeting Laboratory - Custom generated mouse model solutions for INTU 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for INTU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for INTU 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for INTU 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTU
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate INTU:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-26a hsa-miR-23c hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidINTU 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for INTU
    Sirion Biotech Customized adenovirus for overexpression of INTU

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for INTU (see all 7)
    OriGene ORF clones in mouse, rat for INTU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTU (NM_015693)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU
    Sirion Biotech Customized lentivirus for stable overexpression of INTU 
                         Customized lentivirus expression plasmids for stable overexpression of INTU 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for INTU
    Search LifeMap BioReagents cell lines for INTU
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTU

    5 Interacting proteins for INTU (Q9ULD63) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CELSR1Q9NYQ63I2D: score=1 
    DVL2O146413I2D: score=1 
    FZD1Q9UP383I2D: score=1 
    NCAM2O153943I2D: score=1 
    VANGL1Q8TAA93I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ISS--
    GO:0008589regulation of smoothened signaling pathway ISS--
    GO:0021513spinal cord dorsal/ventral patterning IEA--
    GO:0042384cilium assembly ISS--
    GO:0060173limb development ISS--

    INTU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INTU

    Search CenterWatch for drugs/clinical trials and news about INTU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for INTU gene: 
    NM_015693.3  

    Unigene Cluster for INTU:

    Inturned planar cell polarity protein
    Hs.391481  [show with all ESTs]
    Unigene Representative Sequence: NM_015693
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504491 ENST00000335251 ENST00000503626(uc003ifk.2 uc011cgq.2)
    ENST00000503952 ENST00000504276 ENST00000506283 ENST00000512995 ENST00000510766
    ENST00000296461
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat INTU
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate INTU:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-26a hsa-miR-23c hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidINTU 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for INTU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTU
    Clone
    Products:
         
    OriGene clones in human, mouse for INTU (see all 7)
    OriGene ORF clones in mouse, rat for INTU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: INTU (NM_015693)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU
    Sirion Biotech Customized lentivirus for stable overexpression of INTU 
                         Customized lentivirus expression plasmids for stable overexpression of INTU 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for INTU
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTU
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTU
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTU

    Additional mRNA sequence: 

    AB033110.1 AK123320.1 AK291481.1 BC130611.1 BC144182.1 HQ234310.1 HQ234311.1 

    4 DOTS entries:

    DT.100746673  DT.310607  DT.121237246  DT.40204235 

    24/32 AceView cDNA sequences (see all 32):

    AI564210 AI803781 AB033110 CA414645 AK123320 NM_015693 AI056201 AW263249 
    BC051698 AA460936 AI811942 BQ949910 AW150229 Z42218 CD252477 W24911 
    BX497550 BX106427 BV202916 AI696253 BG698988 C00590 CF597130 Z38466 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    INTU expression in normal human tissues (normalized intensities)      INTU embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGATCAAA
    INTU Expression
    About this image


    INTU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon

    See INTU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for INTU

    SOURCE GeneReport for Unigene cluster: Hs.391481
        SABiosciences Expression via Pathway-Focused PCR Array including INTU: 
              Primary Cilia in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTU
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for INTU gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Intu1 , 5 inturned planar cell polarity effector homolog (Drosophila)1, 5 80.15(n)1
    80.04(a)1
      3 (19.46 cM)5
    3806141  NM_175515.41  NP_780724.31 
     405312865 
    chicken
    (Gallus gallus)
    Aves INTU1 inturned planar cell polarity effector homolog (Drosophila) 71.46(n)
    67.95(a)
      422494  XM_420459.3  XP_420459.2 
    lizard
    (Anolis carolinensis)
    Reptilia INTU6
    inturned planar cell polarity protein
    60(a)
    1 ↔ 1
    5(136476539-136512370)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.44232 Transcribed sequences 73.29(n)    142014701 
    zebrafish
    (Danio rerio)
    Actinopterygii intu1 inturned planar cell polarity effector homolog (Drosophila) 57.96(n)
    57.09(a)
      100007575  XM_001345962.4  XP_001345998.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta in1 inturned 39.39(n)
    28.43(a)
      40246  NM_176370.2  NP_788548.1 


    ENSEMBL Gene Tree for INTU (if available)
    TreeFam Gene Tree for INTU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1469 SNPs in INTU are shown (see all 1469)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23911881,2
    C,F,H--128552116(+) ACACCC/TTCCCT 1 -- us2k124Minor allele frequency- T:0.44NS EA NA WA CSA 2349
    rs23911891,2
    C,F,A--128552201(+) TAAAAT/AAACTT 1 -- us2k1 tfbs37Minor allele frequency- A:0.28NA WA EA 366
    rs1507252731,2
    --128552375(+) GGTCTA/GTCTGC 1 -- us2k10--------
    rs1390762611,2
    C--128552500(+) GCTGAA/GTCACA 1 -- us2k10--------
    rs1915833511,2
    --128552538(+) CCAGGA/CCCCTC 1 -- us2k10--------
    rs1841568401,2
    --128552635(+) TTTAGA/GTAAGT 1 -- us2k10--------
    rs1494868221,2
    --128552750(+) CATACC/TGGCCA 1 -- us2k10--------
    rs1459858791,2
    --128552998(+) TTACAC/TGCTGC 1 -- us2k10--------
    rs1399176571,2
    --128553077(+) TATATA/GTATTT 1 -- us2k10--------
    rs1886847241,2
    --128553132(+) TTCACA/TTTTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for INTU (128544426 - 128637934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for INTU (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728289CNV Deletion23290073
    esv2728290CNV Deletion23290073
    nsv879923CNV Loss21882294
    nsv830057CNV Loss17160897
    nsv879916CNV Loss21882294
    dgv5712n71CNV Loss21882294
    dgv5711n71CNV Loss21882294
    nsv830056CNV Loss17160897
    nsv879925CNV Loss21882294
    nsv879924CNV Loss21882294


    Human Gene Mutation Database (HGMD): INTU
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing INTU
    DNA2.0 Custom Variant and Variant Library Synthesis for INTU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INTU for disorders           About MalaCards
    OMIM gene information: 610621    OMIM disorders: --


    INTU for disorders           About GeneDecksing


    Export disorders for INTU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for INTU gene integrated from 9 sources:
    (articles sorted by number of sources associating them with INTU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. PCP effector proteins inturned and fuzzy play nonredun dant roles in the patterning but not convergent extension of mammalian neural tu be. (PubMed id 21761479)1, 3 Heydeck W. and Liu A. (2011)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. (PubMed id 21948523)1 Al-Balool H.H....Jackson M.S. (2011)
    7. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. (PubMed id 16493421)1 Park T.J....Wallingford J.B. (2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27152 HGNC: 29239 AceView: PDZK6 Ensembl:ENSG00000164066 euGenes: HUgn27152
    ECgene: INTU H-InvDB: INTU

    (According to HUGE)
    About This Section
    HUGE: KIAA1284

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for INTU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for INTU gene:
    Search GeneIP for patents involving INTU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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