INTU Gene
protein-coding GIFtS: 44
GCID: GC04P128554
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inturned planar cell polarity effector homolog (Drosophila)(Previous name: PDZ domain containing 6 )
(Previous symbols: PDZK6, PDZD6)
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Aliases
for INTU gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inturned Planar Cell Polarity Effector Homolog (Drosophila)1 2 | | PDZ Domain-Containing Protein 62 3 | | PDZK61 2 3 5 | | INT2 | | PDZD61 2 3 | | Homolog Of Inturned2 | | KIAA12841 3 5 | | Protein Inturned2 | | PDZ Domain Containing 61 2 | | Inturned Planar Cell Polarity Effector Homolog3 |
Export aliases for INTU gene to outside databasesPrevious GC identifers: GC04P128774 GC04P124281 |
Summaries
for INTU gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6Function: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling theorganization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface,which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role indefinition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect onhedgehog signaling (By similarity)
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Genomic Views
for INTU gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the INTU gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C FOXC1 POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for INTU
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTU |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q28.1 Ensembl cytogenetic band: 4q28.1 HGNC cytogenetic band: 4q28.2INTU Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P128554: view genomic region
(about GC identifiers)
Start:
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128,544,426 bp from pter |
End:
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128,637,934 bp from pter |
Size:
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93,509 bases |
Orientation:
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plus strand |
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Proteins
for INTU gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6 (See
protein sequence)Recommended Name: Protein inturned Size: 942 amino acids; 105648 Da
Subcellular location: Cytoplasm (By similarity). Cell surface (By similarity). Note=Enriched at the apical surface inciliated cells (By similarity)
Sequence caution: Sequence=BAA86598.1; Type=Erroneous initiation;
Secondary accessions: A1L4N5 D6RAE6 D6RBT4 Q4W5I8 Q86V55Alternative splicing: 4 isoforms: Q9ULD6-1 Q9ULD6-2 Q9ULD6-3 Q9ULD6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for INTU: NX_Q9ULD6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9ULD6
INTU Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056508.2
ENSEMBL proteins: ENSP00000422550 ENSP00000334003 ENSP00000426287 ENSP00000421995 ENSP00000426171 ENSP00000427150 ENSP00000296461
Human Recombinant Protein Products for INTU:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
INTU for ontologies About GeneDecksing
INTU Antibody Products:
Assay Products for INTU: |
Protein
Domains /
Families
for INTU gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
INTU for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9ULD6ProtoNet protein and cluster: Q9ULD6 1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain
UniProtKB/Swiss-Prot: INTU_HUMAN, Q9ULD6Similarity: Belongs to the inturned familySimilarity: Contains 1 PDZ (DHR) domain |
Function
for INTU gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: INTU_HUMAN, Q9ULD6Function: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling theorganization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface,which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role indefinition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect onhedgehog signaling (By similarity)Phenotypes:
1 GenomeRNAi human phenotype for INTU:
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Intu):
INTU for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Intutm1.2Aliu for INTU
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTU (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTU
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: INTU (NM_015693) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTU | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU |
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Pathways & Interactions
for INTU gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INTU
5 Interacting proteins for INTU (Q9ULD63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0007399 | nervous system development |
ISS | -- | | GO:0008589 | regulation of smoothened signaling pathway |
ISS | -- | | GO:0042384 | cilium assembly |
ISS | -- | | GO:0060173 | limb development |
ISS | -- |
INTU for ontologies About GeneDecksing
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Drugs & Compounds
for INTU gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for INTU
Search CenterWatch for drugs/clinical trials and news about INTU
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Transcripts
for INTU gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for INTU gene: NM_015693.3 Unigene Cluster for INTU: Inturned planar cell polarity effector homolog (Drosophila) Hs.391481 [show with all ESTs]Unigene Representative Sequence: NM_0156939 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504491 ENST00000335251 ENST00000503626(uc003ifk.2 uc011cgq.2)
ENST00000503952 ENST00000504276 ENST00000506283 ENST00000512995 ENST00000510766
ENST00000296461
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTU (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTU
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: INTU (NM_015693) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for INTU | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU |
Additional cDNA sequence: AB033110.1 AK123320.1 AK291481.1 BC130611.1 BC144182.1 HQ234310.1 HQ234311.1 4 DOTS entries: DT.100746673 DT.310607 DT.121237246 DT.40204235 24/32 AceView cDNA sequences (see all 32): AI056201 AI803781 AK123320 AI564210 AB033110 NM_015693 CA414645 CF597130 BX106427 AI016810 AI811942 Z42218 C00590 BC051698 AW150229 Z38466 AI696253 BV202916 BG698988 CD252477 AW263249 AA460936 BQ949910 BX497550
GeneLoc Exon Structure
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Expression
for INTU gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| INTU expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGATCAAA
About this image
See INTU Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for INTU
SOURCE GeneReport for Unigene cluster: Hs.391481
SABiosciences Expression via Pathway-Focused PCR Array including INTU:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTU
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat INTU | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTU | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTU | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU |
Orthologs
for INTU gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for INTU gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for INTU (if available)
TreeFam Gene Tree for INTU (if available) |
Paralogs
for INTU gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for INTU gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for INTU (128544426 - 128637934 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INTU: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTU |
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Disorders
/ Diseases
for INTU gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 INTU for disorders About MalaCards
INTU for disorders About GeneDecksing
OMIM gene information: 610621
OMIM disorders: --
Export disorders for INTU gene to outside databases
|
Publications
for INTU gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for INTU gene integrated from 9 sources:
(articles sorted by number of sources associating them with INTU) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. (PubMed id 21948523)1 Al-Balool H.H....Jackson M.S. (2011)
- Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. (PubMed id 16493421)1 Park T.J....Wallingford J.B. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)
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External Searches for INTU gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing INTU gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing INTU gene
(According to HUGE)
About This Section
| |
Specialized Databases showing INTU gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for INTU | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for INTU gene:
Search GeneIP for patents involving INTU
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for INTU gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for INTU | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for INTU | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for INTU | | | OriGene Protein Over-expression Lysate for INTU | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for INTU | | OriGene 3'-UTR Clone for INTU | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for INTU | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for INTU | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for INTU | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for INTU | | OriGene Custom Protein Services for INTU | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat INTU | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing INTU | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat INTU | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat INTU | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat INTU | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat INTU |
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 | | | INTU Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTU |
|  |  |  |  | | | | ThermoFisher Antibody for INTU |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTU |
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