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INTS9 Gene

protein-coding   GIFtS: 49
GCID: GC08M028625

Integrator Complex Subunit 9

  See INTS9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrator Complex Subunit 91 2     CPSF2L2
RC742 3 5     Int93
Protein Related To CPSF Subunits Of 74 KDa2 3     RC-743
INT92 5     

External Ids:    HGNC: 255921   Entrez Gene: 557562   Ensembl: ENSG000001042997   OMIM: 6113525   UniProtKB: Q9NV883   

Export aliases for INTS9 gene to outside databases

Previous GC identifers: GC08M028683 GC08M027170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for INTS9 Gene:
This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA
polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to
the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript
variants have been described.(provided by RefSeq, Feb 2010)

GeneCards Summary for INTS9 Gene:
INTS9 (integrator complex subunit 9) is a protein-coding gene. Diseases associated with INTS9 include opisthorchiasis. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: INT9_HUMAN, Q9NV88
Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the INTS9 gene promoter:
         Spz1   AML1a   FOXF2   CUTL1   HNF-3beta   AREB6   S8   FOXJ2 (long isoform)   IRF-7A   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidINTS9 promoter sequence
   Search Chromatin IP Primers for INTS9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat INTS9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21.1

INTS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INTS9 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M028625:  view genomic region     (about GC identifiers)

Start:
28,625,175 bp from pter      End:
28,747,759 bp from pter
Size:
122,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: INT9_HUMAN, Q9NV88 (See protein sequence)
Recommended Name: Integrator complex subunit 9  
Size: 658 amino acids; 73814 Da
Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5,
INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12
Miscellaneous: Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that
binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure
Sequence caution: Sequence=AAB67601.1; Type=Erroneous gene model prediction;
Secondary accessions: B7Z560 B7Z6M5 O00224 Q8TB16
Alternative splicing: 3 isoforms:  Q9NV88-1   Q9NV88-2   Q9NV88-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for INTS9: NX_Q9NV88

Explore proteomics data for INTS9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys58, Lys459, Lys510, Lys653
  • Modification sites at PhosphoSitePlus

  • See INTS9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138631.1  NP_001166033.1  NP_060720.2  

    ENSEMBL proteins: 
     ENSP00000427952   ENSP00000429065   ENSP00000398208   ENSP00000430943   ENSP00000429691  
     ENSP00000430083   ENSP00000427789   ENSP00000428135   ENSP00000429539   ENSP00000430067  
     ENSP00000429188   ENSP00000380520  

    INTS9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for INTS9

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001279 Beta-lactamas-like
     IPR022712 Beta_Casp
     IPR027074 Integrator_9su

    Graphical View of Domain Structure for InterPro Entry Q9NV88

    ProtoNet protein and cluster: Q9NV88

    UniProtKB/Swiss-Prot: INT9_HUMAN, Q9NV88
    Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like
    family. INTS9 subfamily


    Find genes that share domains with INTS9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: INT9_HUMAN, Q9NV88
    Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2
    transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal
    domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239144
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with INTS9           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for INTS9
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate INTS9:
    hsa-miR-3163 hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidINTS9 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): INTS9 (NM_018250)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS9

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    INT9_HUMAN, Q9NV88: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0032039integrator complex IDA16239144

    Find genes that share ontologies with INTS9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for INTS9
    Interactions:

        Search GeneGlobe Interaction Network for INTS9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for INTS9 (Q9NV883 ENSP000003982084) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    CPSF3LQ5TA453, ENSP000004134934I2D: score=1 STRING: ENSP00000413493
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016180snRNA processing IDA16239144

    Find genes that share ontologies with INTS9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for INTS9 (INT9)

    10 Novoseek inferred chemical compound relationships for INTS9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-dimethylaminopyridine 71.3 1 17249653 (1)
    imine 68.7 1 17088970 (1)
    hydride 51.9 2 18060114 (1), 17377937 (1)
    palladium 50.8 1 11495429 (1)
    methylene 42.8 1 11749623 (1)
    toluene 26.2 1 12590546 (1)
    chloride 24 1 17249653 (1)
    hydrogen 19.3 2 11272557 (1), 17341073 (1)
    phosphorus 15.6 1 15606202 (1)
    zinc 0.323 1 12691590 (1)



    Find genes that share compounds with INTS9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for INTS9 gene (3 alternative transcripts): 
    NM_001145159.2  NM_001172562.1  NM_018250.3  

    Unigene Cluster for INTS9:

    Integrator complex subunit 9
    Hs.162397  [show with all ESTs]
    Unigene Representative Sequence: NM_018250
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000523303 ENST00000521022(uc011lav.2) ENST00000416984(uc003xha.3 uc011law.2 uc011lax.2 uc010lvc.3)
    ENST00000521777 ENST00000517383 ENST00000522363 ENST00000520316 ENST00000519578
    ENST00000520005 ENST00000521070 ENST00000522074 ENST00000520983 ENST00000523436
    ENST00000518510 ENST00000524081 ENST00000523076 ENST00000520437 ENST00000520184

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate INTS9:
    hsa-miR-3163 hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidINTS9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat INTS9
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): INTS9 (NM_018250)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for INTS9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat INTS9
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for INTS9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat INTS9
      QuantiTect SYBR Green Assays in human, mouse, rat INTS9
      QuantiFast Probe-based Assays in human, mouse, rat INTS9

    Additional mRNA sequence: 

    AK001733.1 AK225072.1 AK225530.1 AK295977.1 AK298468.1 AK300593.1 AK304525.1 BC016687.1 
    BC025267.1 NR_026826.2 

    14 DOTS entries:

    DT.415082  DT.100785175  DT.100785181  DT.100785180  DT.99986251  DT.91754387  DT.97847048  DT.40238374 
    DT.453138  DT.101973464  DT.40108432  DT.91803489  DT.91809715  DT.97824300 

    Selected AceView cDNA sequences (see all 184):

    BE892995 BQ054463 BQ643130 BQ061521 BG676744 BQ058437 CB157704 AK001733 
    CR600799 BX353160 AI570992 CA395923 BQ890043 BM742409 BM893996 AL519455 
    AI468563 CK823543 N75465 BU162063 AA565595 BM975838 BM931164 BE502695 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for INTS9 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c
    SP1:                                            -                       -                                                           -     -               
    SP2:                                            -                       -                                   -                       -     -               
    SP3:                                                                    -                                                                                 
    SP4:                                                                                                        -                                             
    SP5:                                                                                                                                -                     


    ECgene alternative splicing isoforms for INTS9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    INTS9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGCGGAG
    INTS9 Expression
    About this image

    INTS9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    INTS9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162397
        Custom PCR Arrays for INTS9
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    QuantiFast Probe-based Assays in human, mouse, rat INTS9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for INTS9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for INTS9 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ints91 , 5 integrator complex subunit 91, 5 89.77(n)1
    97.26(a)1
      14 (33.81 cM)5
    2109251  NM_153414.41  NP_700463.21 
     649500455 
    chicken
    (Gallus gallus)
    Aves INTS91 integrator complex subunit 9 80.29(n)
    93.16(a)
      422023  NM_001031100.1  NP_001026271.1 
    lizard
    (Anolis carolinensis)
    Reptilia INTS96
    integrator complex subunit 9
    91(a)
    1 ↔ 1
    GL343333.1(1106842-1205009)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160932 Xenopus laevis transcribed sequence with moderate similarity more 78.03(n)    CA793955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM861464.12   -- 71.12(n)    BM861464.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS91 Integrator 9 57.44(n)
    53.48(a)
      39763  NM_140581.4  NP_648838.3 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F19F10.121 CELE_F19F10.12 49.51(n)
    35.83(a)
      179142  NM_072552.5  NP_504953.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G075301 AT3G07530 42.5(n)
    29.94(a)
      819942  NM_111631.2  NP_187409.2 


    ENSEMBL Gene Tree for INTS9 (if available)
    TreeFam Gene Tree for INTS9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for INTS9 (see all 2372)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671875741,2
    C--27213630(+) TACCA-/TAAAAG 4 -- int10--------
    rs1418733991,2
    C--27226600(+) TAATT-/AACTC 
            
    AAGGG
    4 -- int10--------
    rs125425141,2
    C,H--27283369(+) ttggcG/Cgggct 4 -- int11Minor allele frequency- C:0.00NA 2
    rs353748831,2
    C--28635057(+) TTTTT-/TGGCAG 4 -- int10--------
    rs666565301,2
    C--28636110(+) AGACCG/-GGAAG 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs347353531,2
    C--28637684(+) CACTGGAA/-GAAGA 4 -- int11Minor allele frequency- -:0.50NA 2
    rs350566701,2
    C,F--28650069(+) AAAAAA/-TTTGT 4 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs114046921,2
    C--28650429(+) AAAAAA/-GTGAC 4 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs677336371,2
    C--28653157(+) AAAAA-/AAAAA 
            
    GAAGA
    4 -- int11Minor allele frequency- AAAAA:0.00NA 2
    rs357715201,2
    C--28663603(+) TAGCCA/-AGGCA 4 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for INTS9 (28625175 - 28747759 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for INTS9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671910CNV Deletion23128226
    esv2736810CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing INTS9
    DNA2.0 Custom Variant and Variant Library Synthesis for INTS9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611352    OMIM disorders: --

    1 disease for INTS9:    
    About MalaCards
    opisthorchiasis

    1 disease from the University of Copenhagen DISEASES database for INTS9:
    Opisthorchiasis

    Find genes that share disorders with INTS9           About GenesLikeMe


    Export disorders for INTS9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for INTS9 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with INTS9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PubMed id 16239144)1, 2, 3 Baillat D....Shiekhattar R. (Cell 2005)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (Nature 2006)
    3. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PubMed id 15684398)1, 2 Dominski Z.... Marzluff W.F. (Mol. Cell. Biol. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. snRNA 3' end formation requires heterodimeric association of integrator subunits. (PubMed id 22252320)1 Albrecht T.R. and Wagner E.J. (Mol. Cell. Biol. 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55756 HGNC: 25592 AceView: FLJ10871 Ensembl:ENSG00000104299 euGenes: HUgn55756
    ECgene: INTS9 H-InvDB: INTS9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for INTS9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for INTS9 gene:
    Search GeneIP for patents involving INTS9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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