Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INTS9 Gene

Aliases for INTS9 Gene

  • Integrator Complex Subunit 9 2 3
  • INT9 3 4 6
  • RC74 3 4 6
  • Protein Related To CPSF Subunits Of 74 KDa 3 4
  • CPSF2L 3
  • RC-74 4

External Ids for INTS9 Gene

Summaries for INTS9 Gene

Entrez Gene Summary for INTS9 Gene

  • This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

GeneCards Summary for INTS9 Gene

INTS9 (Integrator Complex Subunit 9) is a Protein Coding gene. Diseases associated with INTS9 include opisthorchiasis. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for INTS9 Gene

  • Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Wiki entry for INTS9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INTS9 Gene

Genomics for INTS9 Gene

Genomic Location for INTS9 Gene

Start:
28,767,658 bp from pter
End:
28,890,242 bp from pter
Size:
122,585 bases
Orientation:
Minus strand

Genomic View for INTS9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for INTS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INTS9 Gene

Regulatory Elements for INTS9 Gene

Proteins for INTS9 Gene

  • Protein details for INTS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV88-INT9_HUMAN
    Recommended name:
    Integrator complex subunit 9
    Protein Accession:
    Q9NV88
    Secondary Accessions:
    • B7Z560
    • B7Z6M5
    • O00224
    • Q8TB16

    Protein attributes for INTS9 Gene

    Size:
    658 amino acids
    Molecular mass:
    73814 Da
    Quaternary structure:
    • Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
    Miscellaneous:
    • Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure
    SequenceCaution:
    • Sequence=AAB67601.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for INTS9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INTS9 Gene

Proteomics data for INTS9 Gene at MOPED

Post-translational modifications for INTS9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58, Lys459, Lys510, and Lys653

No data available for DME Specific Peptides for INTS9 Gene

Domains for INTS9 Gene

Protein Domains for INTS9 Gene

UniProtKB/Swiss-Prot:

INT9_HUMAN
Family:
  • Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.:
    • Q9NV88
genes like me logo Genes that share domains with INTS9: view

No data available for Gene Families for INTS9 Gene

Function for INTS9 Gene

Molecular function for INTS9 Gene

UniProtKB/Swiss-Prot Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes

Gene Ontology (GO) - Molecular Function for INTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239144
genes like me logo Genes that share ontologies with INTS9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for INTS9 Gene

Localization for INTS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INTS9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for INTS9 Gene COMPARTMENTS Subcellular localization image for INTS9 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for INTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0032039 integrator complex IDA 16239144
genes like me logo Genes that share ontologies with INTS9: view

Pathways for INTS9 Gene

SuperPathways for INTS9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INTS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016180 snRNA processing IDA 16239144
genes like me logo Genes that share ontologies with INTS9: view

No data available for Pathways by source for INTS9 Gene

Compounds for INTS9 Gene

(10) Novoseek inferred chemical compound relationships for INTS9 Gene

Compound -log(P) Hits PubMed IDs
4-dimethylaminopyridine 71.3 1
imine 68.7 1
hydride 51.9 2
palladium 50.8 1
methylene 42.8 1
genes like me logo Genes that share compounds with INTS9: view

Transcripts for INTS9 Gene

Unigene Clusters for INTS9 Gene

Integrator complex subunit 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for INTS9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for INTS9 Gene

GeneLoc Exon Structure for
INTS9
ECgene alternative splicing isoforms for
INTS9

Expression for INTS9 Gene

mRNA expression in normal human tissues for INTS9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for INTS9 Gene

SOURCE GeneReport for Unigene cluster for INTS9 Gene Hs.162397

genes like me logo Genes that share expressions with INTS9: view

Orthologs for INTS9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INTS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INTS9 36
  • 99.7 (n)
  • 100 (a)
INTS9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia INTS9 36
  • 90.07 (n)
  • 97.72 (a)
INTS9 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia INTS9 36
  • 90.37 (n)
  • 97.87 (a)
INTS9 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ints9 36
  • 89.77 (n)
  • 97.26 (a)
Ints9 16
Ints9 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia INTS9 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INTS9 37
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves INTS9 36
  • 80.29 (n)
  • 93.16 (a)
INTS9 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INTS9 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16093 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ints9 36
  • 78.42 (n)
  • 90.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ints9 36
  • 73.2 (n)
  • 80.24 (a)
ints9 37
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005494 36
  • 56.67 (n)
  • 54.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS9 36
  • 57.44 (n)
  • 53.48 (a)
IntS9 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F19F10.12 36
  • 49.51 (n)
  • 35.83 (a)
F19F10.12 37
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G07530 36
  • 42.5 (n)
  • 29.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7245 37
  • 50 (a)
OneToOne
Species with no ortholog for INTS9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INTS9 Gene

ENSEMBL:
Gene Tree for INTS9 (if available)
TreeFam:
Gene Tree for INTS9 (if available)

Paralogs for INTS9 Gene

No data available for Paralogs for INTS9 Gene

Variants for INTS9 Gene

Sequence variations from dbSNP and Humsavar for INTS9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs107069 -- 28,812,907(+) TGATG(C/G)AGATC intron-variant
rs171311 -- 28,805,566(+) ACCAC(C/T)GTATT intron-variant
rs171312 -- 28,801,339(-) ctaat(C/T)ttttt intron-variant
rs171313 -- 28,786,205(+) gggac(C/T)gtgtg intron-variant
rs187094 -- 28,776,413(+) ACCAA(A/G)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for INTS9 Gene

Variant ID Type Subtype PubMed ID
esv2736810 CNV Deletion 23290073
esv2671910 CNV Deletion 23128226

Relevant External Links for INTS9 Gene

HapMap Linkage Disequilibrium report
INTS9

Disorders for INTS9 Gene

(1) MalaCards Diseases for INTS9 Gene

Search for INTS9 Gene in MalaCards »

(1) University of Copenhagen DISEASES for INTS9 Gene

genes like me logo Genes that share disorders with INTS9: view

No data available for UniProtKB/Swiss-Prot for INTS9 Gene

Publications for INTS9 Gene

  1. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. (PMID: 16239144) Baillat D. … Shiekhattar R. (Cell 2005) 2 3 4
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF- 100. (PMID: 15684398) Dominski Z. … Marzluff W.F. (Mol. Cell. Biol. 2005) 3 4

Products for INTS9 Gene

Sources for INTS9 Gene

Back to Top

Content